ARIH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.25279170
2nuclear pore organization (GO:0006999)4.62089413
3interkinetic nuclear migration (GO:0022027)4.50298623
4cytoplasmic mRNA processing body assembly (GO:0033962)4.45510711
5regulation of RNA export from nucleus (GO:0046831)4.42849659
6pre-miRNA processing (GO:0031054)4.29432842
7mitotic sister chromatid cohesion (GO:0007064)4.18102933
8NLS-bearing protein import into nucleus (GO:0006607)4.08327399
9regulation of nucleobase-containing compound transport (GO:0032239)3.97573303
10monoubiquitinated protein deubiquitination (GO:0035520)3.83339220
11positive regulation of histone deacetylation (GO:0031065)3.79758038
12negative regulation of translation, ncRNA-mediated (GO:0040033)3.70535335
13regulation of translation, ncRNA-mediated (GO:0045974)3.70535335
14negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.70535335
15mRNA stabilization (GO:0048255)3.69105513
16RNA stabilization (GO:0043489)3.69105513
17pore complex assembly (GO:0046931)3.66939595
18UDP-N-acetylglucosamine metabolic process (GO:0006047)3.55052787
19heterochromatin organization (GO:0070828)3.52306147
20hippo signaling (GO:0035329)3.51144465
21positive regulation of cardiac muscle cell differentiation (GO:2000727)3.48261813
22negative regulation of systemic arterial blood pressure (GO:0003085)3.45624199
23protein localization to kinetochore (GO:0034501)3.39377025
24glucocorticoid receptor signaling pathway (GO:0042921)3.38450701
25protein K11-linked deubiquitination (GO:0035871)3.35987481
26histone H3-K4 trimethylation (GO:0080182)3.32069572
27cAMP catabolic process (GO:0006198)3.28322402
28behavioral response to nicotine (GO:0035095)3.25624855
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.25433500
30pericardium development (GO:0060039)3.19642995
31cellular response to ATP (GO:0071318)3.18223054
32negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.15570899
33protein localization to endosome (GO:0036010)3.13766515
34protein K48-linked deubiquitination (GO:0071108)3.13357292
35corticosteroid receptor signaling pathway (GO:0031958)3.13072641
36negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.12063834
37cyclic nucleotide catabolic process (GO:0009214)3.09274990
38snRNA transcription (GO:0009301)3.07485348
39detection of light stimulus involved in visual perception (GO:0050908)2.97618475
40detection of light stimulus involved in sensory perception (GO:0050962)2.97618475
41regulation of telomere maintenance via telomerase (GO:0032210)2.94498412
42sister chromatid segregation (GO:0000819)2.94452190
43regulation of gene silencing by RNA (GO:0060966)2.93127138
44regulation of posttranscriptional gene silencing (GO:0060147)2.93127138
45regulation of gene silencing by miRNA (GO:0060964)2.93127138
46negative regulation of histone methylation (GO:0031061)2.92955471
47chromatin assembly (GO:0031497)2.92262805
48negative regulation of Rho protein signal transduction (GO:0035024)2.89860663
49protein localization to chromosome, centromeric region (GO:0071459)2.89618151
50mitotic chromosome condensation (GO:0007076)2.88631073
51gamma-aminobutyric acid transport (GO:0015812)2.88622194
52peptidyl-lysine dimethylation (GO:0018027)2.84908073
53hypotonic response (GO:0006971)2.83649480
54histone H2A monoubiquitination (GO:0035518)2.83603489
55positive regulation of protein deacetylation (GO:0090312)2.83516663
56establishment of endothelial barrier (GO:0061028)2.82295045
57peptidyl-threonine modification (GO:0018210)2.81350796
58peptidyl-threonine phosphorylation (GO:0018107)2.80957098
59histone H4-K16 acetylation (GO:0043984)2.76274631
60spliceosomal tri-snRNP complex assembly (GO:0000244)2.74741202
61sulfation (GO:0051923)2.73894476
62negative regulation of cell cycle G2/M phase transition (GO:1902750)2.73758723
63cerebellar Purkinje cell differentiation (GO:0021702)2.72759927
64regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.70936163
65growth hormone receptor signaling pathway (GO:0060396)2.70715756
66regulation of establishment of cell polarity (GO:2000114)2.69490731
67histone H3-K36 demethylation (GO:0070544)2.69146565
68regulation of mRNA stability (GO:0043488)2.68422024
69relaxation of cardiac muscle (GO:0055119)2.66881457
70histone H3-K9 demethylation (GO:0033169)2.66007176
71positive regulation of mitotic sister chromatid separation (GO:1901970)2.65332964
72positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.65332964
73positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.65332964
74regulation of pigment cell differentiation (GO:0050932)2.63995019
75somite development (GO:0061053)2.61864140
76smooth muscle tissue development (GO:0048745)2.60346035
77microtubule anchoring (GO:0034453)2.60109149
78regulation of sister chromatid cohesion (GO:0007063)2.58739355
79nucleus localization (GO:0051647)2.58099957
80negative regulation of cytosolic calcium ion concentration (GO:0051481)2.56679501
813-UTR-mediated mRNA stabilization (GO:0070935)2.55982478
82positive regulation of fatty acid oxidation (GO:0046321)2.55823614
83protein K63-linked deubiquitination (GO:0070536)2.55065053
84notochord development (GO:0030903)2.54789658
85kidney morphogenesis (GO:0060993)2.53361450
86regulation of RNA stability (GO:0043487)2.53118051
87artery development (GO:0060840)2.52135631
88negative regulation of glycogen biosynthetic process (GO:0045719)2.51870753
89germ cell migration (GO:0008354)2.51852436
90regulation of alkaline phosphatase activity (GO:0010692)2.50779663
91negative regulation of DNA repair (GO:0045738)2.50037651
92nuclear envelope disassembly (GO:0051081)2.49952276
93membrane disassembly (GO:0030397)2.49952276
94membrane depolarization during action potential (GO:0086010)2.49388987
95mitotic sister chromatid segregation (GO:0000070)2.49302829
96regulation of action potential (GO:0098900)2.49145059
97peristalsis (GO:0030432)2.48526395
98serotonin metabolic process (GO:0042428)2.47610002
99mitotic nuclear envelope disassembly (GO:0007077)2.45805753
100cellular response to osmotic stress (GO:0071470)2.44684428
101peptidyl-lysine methylation (GO:0018022)2.44098919
102trophectodermal cell differentiation (GO:0001829)2.43354654
103positive regulation of action potential (GO:0045760)2.43278758
104phospholipid translocation (GO:0045332)2.42810601
105lipid translocation (GO:0034204)2.42810601
106positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.42530238
107regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.42530238
108adherens junction assembly (GO:0034333)2.42462452
109gene silencing by RNA (GO:0031047)2.42313739
110regulation of acrosome reaction (GO:0060046)2.41899468
111regulation of histone H3-K9 methylation (GO:0051570)2.41073969
112cellular response to sterol (GO:0036315)2.40642099
113insulin-like growth factor receptor signaling pathway (GO:0048009)2.40305435
114histone lysine demethylation (GO:0070076)2.39886532
115neural tube formation (GO:0001841)2.39301111
116replicative senescence (GO:0090399)2.38703862
117response to lipoprotein particle (GO:0055094)2.38607444
118reflex (GO:0060004)2.37657478
119protein localization to microtubule cytoskeleton (GO:0072698)2.37557596
120regulation of establishment or maintenance of cell polarity (GO:0032878)2.37421765
121epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.37348451
122regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.36985962
123protein polyglutamylation (GO:0018095)2.36905440
124dorsal/ventral axis specification (GO:0009950)2.36768009
125positive regulation of SMAD protein import into nucleus (GO:0060391)2.36728947
126protein localization to chromosome (GO:0034502)2.36410859
127lymphangiogenesis (GO:0001946)2.35664149
128embryonic process involved in female pregnancy (GO:0060136)2.33730516
129striated muscle atrophy (GO:0014891)2.33517791
130peptidyl-lysine trimethylation (GO:0018023)2.33346201
131gene silencing (GO:0016458)2.32394404
132protein localization to cytoskeleton (GO:0044380)2.32338078
133response to UV-C (GO:0010225)2.32215187
134negative regulation of hormone biosynthetic process (GO:0032353)2.31684443
135tryptophan catabolic process (GO:0006569)2.31213439
136indole-containing compound catabolic process (GO:0042436)2.31213439
137indolalkylamine catabolic process (GO:0046218)2.31213439
138histone H4-K8 acetylation (GO:0043982)2.30750002
139histone H4-K5 acetylation (GO:0043981)2.30750002
140cellular response to growth hormone stimulus (GO:0071378)2.30582131
141negative regulation of mast cell activation (GO:0033004)2.30238947
142DNA duplex unwinding (GO:0032508)2.29530630
143multicellular organismal movement (GO:0050879)2.28727908
144musculoskeletal movement (GO:0050881)2.28727908
145hormone catabolic process (GO:0042447)2.27917605
146labyrinthine layer development (GO:0060711)2.27887809
147indolalkylamine metabolic process (GO:0006586)2.27662323
148retrograde transport, vesicle recycling within Golgi (GO:0000301)2.27547905
149DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.27264493
150negative regulation of potassium ion transmembrane transport (GO:1901380)2.27235222
151regulation of clathrin-mediated endocytosis (GO:2000369)2.27027860
152protein targeting to Golgi (GO:0000042)2.26959655
153cell proliferation in forebrain (GO:0021846)2.26929022
154spinal cord motor neuron differentiation (GO:0021522)2.26876011
155magnesium ion transport (GO:0015693)2.26838260
156DNA geometric change (GO:0032392)2.26756258
157ovulation cycle (GO:0042698)2.26463689
158positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.25939278
159phosphorelay signal transduction system (GO:0000160)2.25914393
160regulation of protein deacetylation (GO:0090311)2.25795294
161focal adhesion assembly (GO:0048041)2.25225660
162cell-substrate adherens junction assembly (GO:0007045)2.25225660
163regulation of DNA endoreduplication (GO:0032875)2.25182037
164regulation of transforming growth factor beta2 production (GO:0032909)2.25075648
165regulation of interleukin-12 biosynthetic process (GO:0045075)2.24555820
166neuron maturation (GO:0042551)2.24513452
167negative regulation of fatty acid transport (GO:2000192)2.24321500
168anterior/posterior axis specification, embryo (GO:0008595)2.24238973
169embryonic placenta development (GO:0001892)2.24075358
170regulation of hippo signaling (GO:0035330)2.23754772
171regulation of protein polyubiquitination (GO:1902914)2.22590721
172head development (GO:0060322)2.22184205
173chromatin silencing (GO:0006342)2.22068868
174neuron remodeling (GO:0016322)2.21749702
175positive regulation of developmental pigmentation (GO:0048087)2.21519474
176regulation of histone deacetylation (GO:0031063)2.20839930
177histone demethylation (GO:0016577)2.20608403
178positive regulation of chromosome segregation (GO:0051984)2.20421106
179kynurenine metabolic process (GO:0070189)2.20230579
180rRNA catabolic process (GO:0016075)2.20219457
181negative regulation of TOR signaling (GO:0032007)2.20100534
182protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.19553273
183histone H3-K4 methylation (GO:0051568)2.19459603
184positive regulation of fatty acid beta-oxidation (GO:0032000)2.19304845
185intestinal epithelial cell development (GO:0060576)2.19210692
186establishment of protein localization to Golgi (GO:0072600)2.19034943
187primary amino compound metabolic process (GO:1901160)2.18982083
188phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.18398945
189regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.18398532
190negative regulation of cell size (GO:0045792)2.15901908
191nuclear envelope organization (GO:0006998)2.13304271
192cellular senescence (GO:0090398)2.12935996
193cell-substrate junction assembly (GO:0007044)2.11452686

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.50656904
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.34530572
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.27722836
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.83140310
5EZH2_22144423_ChIP-Seq_EOC_Human3.57404540
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.44271979
7GBX2_23144817_ChIP-Seq_PC3_Human3.37799238
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.95107053
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.74432906
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.60313425
11* MYC_22102868_ChIP-Seq_BL_Human2.51577495
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42898737
13TCF7_22412390_ChIP-Seq_EML_Mouse2.37296975
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30795145
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28669012
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26943197
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.25342502
18SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.19194798
19TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.17299962
20SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.10300853
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.08660252
22* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.04944824
23* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03376577
24* FUS_26573619_Chip-Seq_HEK293_Human1.98719350
25AHR_22903824_ChIP-Seq_MCF-7_Human1.97460840
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.95872387
27* FOXO3_23340844_ChIP-Seq_DLD1_Human1.94040147
28KDM2B_26808549_Chip-Seq_DND41_Human1.90534280
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86031541
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.85514787
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.79124460
32KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.78840445
33KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.78840445
34KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.78840445
35EWS_26573619_Chip-Seq_HEK293_Human1.75596560
36* STAT3_23295773_ChIP-Seq_U87_Human1.74532565
37ARNT_22903824_ChIP-Seq_MCF-7_Human1.71703252
38SMAD4_21799915_ChIP-Seq_A2780_Human1.71541671
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.70096616
40TAF15_26573619_Chip-Seq_HEK293_Human1.68477391
41AR_21572438_ChIP-Seq_LNCaP_Human1.68449423
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.68310595
43VDR_22108803_ChIP-Seq_LS180_Human1.67909914
44P300_19829295_ChIP-Seq_ESCs_Human1.64112449
45* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63157818
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.62618340
47TCF4_23295773_ChIP-Seq_U87_Human1.62407434
48* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.62244644
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61494707
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.61430401
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60298843
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59728247
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59697140
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.59576913
55ER_23166858_ChIP-Seq_MCF-7_Human1.59451561
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.59330277
57P300_27058665_Chip-Seq_ZR-75-30cells_Human1.58069078
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58020989
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55441432
60FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.55274439
61ZNF274_21170338_ChIP-Seq_K562_Hela1.53061497
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.49991809
63IGF1R_20145208_ChIP-Seq_DFB_Human1.48667532
64STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.47658172
65DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.47300836
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.47230724
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.46163179
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44561315
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44561315
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.43620731
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43087896
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.41997057
73E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40876342
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.39517887
75MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38969749
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.38576661
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38301055
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38223704
79CBP_20019798_ChIP-Seq_JUKART_Human1.38223704
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38115289
81KDM2B_26808549_Chip-Seq_K562_Human1.37074027
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.36704270
83KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36614632
84JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34183012
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34088533
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33386353
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32711863
88* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.32531259
89ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31657256
90BRD4_25478319_ChIP-Seq_HGPS_Human1.31243504
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29822256
92CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29609354
93NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.29434908
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28512664
95MYB_26560356_Chip-Seq_TH2_Human1.27616470
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26088668
97ELK3_25401928_ChIP-Seq_HUVEC_Human1.24993106
98ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24986570
99EZH2_27304074_Chip-Seq_ESCs_Mouse1.23736290
100EP300_21415370_ChIP-Seq_HL-1_Mouse1.23615413
101CLOCK_20551151_ChIP-Seq_293T_Human1.23349241
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23245212
103FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23170494
104* NCOR1_26117541_ChIP-Seq_K562_Human1.23064660
105BCAT_22108803_ChIP-Seq_LS180_Human1.21928222
106BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21883778
107MYB_26560356_Chip-Seq_TH1_Human1.21786713
108AR_25329375_ChIP-Seq_VCAP_Human1.20127350
109RXR_22108803_ChIP-Seq_LS180_Human1.19771286
110IRF1_19129219_ChIP-ChIP_H3396_Human1.19412819
111* MAF_26560356_Chip-Seq_TH1_Human1.19233014
112UTX_26944678_Chip-Seq_JUKART_Human1.19164324
113EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19158629
114FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.18837173
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18686313
116NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17684926
117SOX2_21211035_ChIP-Seq_LN229_Gbm1.17611745
118FLI1_21867929_ChIP-Seq_TH2_Mouse1.17420473
119TP53_18474530_ChIP-ChIP_U2OS_Human1.17006636
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16933560
121PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16636070
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16189070
123ESR1_20079471_ChIP-ChIP_T-47D_Human1.15941971
124PRDM14_20953172_ChIP-Seq_ESCs_Human1.15134563
125HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14612236
126CHD1_26751641_Chip-Seq_LNCaP_Human1.14418940
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14348513
128NOTCH1_21737748_ChIP-Seq_TLL_Human1.14294469
129EED_16625203_ChIP-ChIP_MESCs_Mouse1.14219077
130AR_21909140_ChIP-Seq_LNCAP_Human1.13667548
131RUNX_20019798_ChIP-Seq_JUKART_Human1.13028923
132SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12476334
133NANOG_18555785_Chip-Seq_ESCs_Mouse1.11770822
134NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11515274
135KDM2B_26808549_Chip-Seq_REH_Human1.11223720
136SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10950854
137FLI1_27457419_Chip-Seq_LIVER_Mouse1.09467519
138WT1_19549856_ChIP-ChIP_CCG9911_Human1.09203647
139STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09175017
140RNF2_27304074_Chip-Seq_ESCs_Mouse1.08926828
141* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08913250
142* ATF3_27146783_Chip-Seq_COLON_Human1.08516680
143ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08199714
144JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07682146
145ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07551344
146RNF2_27304074_Chip-Seq_NSC_Mouse1.07279423
147NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06749640
148NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06749640
149TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06497532
150DROSHA_22980978_ChIP-Seq_HELA_Human1.05864689
151* RUNX1_27514584_Chip-Seq_MCF-7_Human1.05825563
152GATA6_25053715_ChIP-Seq_YYC3_Human1.05800191
153CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05619846
154RUNX2_22187159_ChIP-Seq_PCA_Human1.05582002
155TCF3_18692474_ChIP-Seq_MESCs_Mouse1.05222834
156SMAD4_21741376_ChIP-Seq_EPCs_Human1.05130970
157ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05060420
158CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04992934
159LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04874172
160P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04838049
161SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04753715
162BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04083591
163RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03051253
164ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02739655
165NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02706615
166TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02494726
167TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02380767
168CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01235349
169UBF1/2_26484160_Chip-Seq_HMECs_Human1.01127145
170TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99937265
171* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98297172
172* NANOG_21062744_ChIP-ChIP_HESCs_Human0.98196341
173FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.98156051
174TCF4_22108803_ChIP-Seq_LS180_Human0.97677887
175CJUN_26792858_Chip-Seq_BT549_Human0.97621679
176SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97428569
177PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.97344708
178Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96734164
179TP63_17297297_ChIP-ChIP_HaCaT_Human0.96430197
180* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96068217
181FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95929698
182TP53_22127205_ChIP-Seq_IMR90_Human0.95508100
183VDR_21846776_ChIP-Seq_THP-1_Human0.93723698
184TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.93299438
185CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92466351
186TP53_16413492_ChIP-PET_HCT116_Human0.91629998
187ESR2_21235772_ChIP-Seq_MCF-7_Human0.91391045

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.35590011
2MP0010352_gastrointestinal_tract_polyps3.82333999
3MP0002138_abnormal_hepatobiliary_system3.26147989
4MP0005076_abnormal_cell_differentiation2.95437015
5MP0003300_gastrointestinal_ulcer2.93126476
6MP0003646_muscle_fatigue2.74842336
7MP0004145_abnormal_muscle_electrophysio2.67793267
8MP0002877_abnormal_melanocyte_morpholog2.66584737
9MP0005646_abnormal_pituitary_gland2.23426144
10MP0000569_abnormal_digit_pigmentation2.17114147
11MP0003303_peritoneal_inflammation2.15799599
12MP0000733_abnormal_muscle_development2.08577038
13MP0003566_abnormal_cell_adhesion2.00838233
14MP0002160_abnormal_reproductive_system2.00656665
15MP0010307_abnormal_tumor_latency1.94777711
16MP0002928_abnormal_bile_duct1.93400745
17MP0004264_abnormal_extraembryonic_tissu1.92560135
18MP0000631_abnormal_neuroendocrine_gland1.88197089
19MP0003890_abnormal_embryonic-extraembry1.85570095
20MP0003195_calcinosis1.83449756
21MP0010234_abnormal_vibrissa_follicle1.83091848
22MP0004134_abnormal_chest_morphology1.80630520
23MP0008057_abnormal_DNA_replication1.80107418
24MP0004185_abnormal_adipocyte_glucose1.73404754
25MP0002088_abnormal_embryonic_growth/wei1.72411426
26MP0003984_embryonic_growth_retardation1.72108592
27MP0002086_abnormal_extraembryonic_tissu1.70254581
28MP0003091_abnormal_cell_migration1.67905999
29MP0001672_abnormal_embryogenesis/_devel1.66689749
30MP0005380_embryogenesis_phenotype1.66689749
31MP0008961_abnormal_basal_metabolism1.65460346
32MP0008877_abnormal_DNA_methylation1.62121170
33MP0005409_darkened_coat_color1.59408704
34MP0002084_abnormal_developmental_patter1.59375580
35MP0005248_abnormal_Harderian_gland1.56200380
36MP0005623_abnormal_meninges_morphology1.55415066
37MP0004197_abnormal_fetal_growth/weight/1.54511506
38MP0009278_abnormal_bone_marrow1.53144673
39MP0003950_abnormal_plasma_membrane1.52596440
40MP0000427_abnormal_hair_cycle1.51740847
41MP0006292_abnormal_olfactory_placode1.51652417
42MP0003123_paternal_imprinting1.51618908
43MP0005551_abnormal_eye_electrophysiolog1.49372519
44MP0004808_abnormal_hematopoietic_stem1.49284607
45MP0003880_abnormal_central_pattern1.48179908
46MP0004043_abnormal_pH_regulation1.47736540
47MP0002925_abnormal_cardiovascular_devel1.45280641
48MP0001849_ear_inflammation1.44290063
49MP0002396_abnormal_hematopoietic_system1.43828256
50MP0000350_abnormal_cell_proliferation1.43583130
51MP0000537_abnormal_urethra_morphology1.42404695
52MP0004142_abnormal_muscle_tone1.41230551
53MP0000778_abnormal_nervous_system1.40200763
54MP0005666_abnormal_adipose_tissue1.38528991
55MP0001730_embryonic_growth_arrest1.36934947
56MP0005023_abnormal_wound_healing1.36456610
57MP0002272_abnormal_nervous_system1.35705169
58MP0005174_abnormal_tail_pigmentation1.35353049
59MP0009250_abnormal_appendicular_skeleto1.33352858
60MP0003011_delayed_dark_adaptation1.32675626
61MP0003121_genomic_imprinting1.32163109
62MP0000428_abnormal_craniofacial_morphol1.31138450
63MP0008438_abnormal_cutaneous_collagen1.29111354
64MP0002085_abnormal_embryonic_tissue1.28171125
65MP0009046_muscle_twitch1.27115873
66MP0001915_intracranial_hemorrhage1.26094466
67MP0003045_fibrosis1.25894851
68MP0001697_abnormal_embryo_size1.25370229
69MP0010630_abnormal_cardiac_muscle1.24053625
70MP0005389_reproductive_system_phenotype1.22445663
71MP0009053_abnormal_anal_canal1.21675911
72MP0003935_abnormal_craniofacial_develop1.21402500
73MP0004484_altered_response_of1.16818781
74MP0002184_abnormal_innervation1.16777500
75MP0003567_abnormal_fetal_cardiomyocyte1.15481082
76MP0009745_abnormal_behavioral_response1.15158859
77MP0010678_abnormal_skin_adnexa1.14382663
78MP0002837_dystrophic_cardiac_calcinosis1.14230045
79MP0003635_abnormal_synaptic_transmissio1.13739363
80MP0003077_abnormal_cell_cycle1.13526653
81MP0003448_altered_tumor_morphology1.12943625
82MP0004087_abnormal_muscle_fiber1.12638342
83MP0003119_abnormal_digestive_system1.12173623
84MP0001501_abnormal_sleep_pattern1.11597983
85MP0001958_emphysema1.11550675
86MP0002876_abnormal_thyroid_physiology1.10892525
87MP0002734_abnormal_mechanical_nocicepti1.10648163
88MP0002254_reproductive_system_inflammat1.10626886
89MP0009703_decreased_birth_body1.09847961
90MP0003453_abnormal_keratinocyte_physiol1.09399915
91MP0003718_maternal_effect1.08886971
92MP0001502_abnormal_circadian_rhythm1.07432612
93MP0010386_abnormal_urinary_bladder1.06825030
94MP0001348_abnormal_lacrimal_gland1.06462545
95MP0005257_abnormal_intraocular_pressure1.05734823
96MP0005275_abnormal_skin_tensile1.04907547
97MP0000432_abnormal_head_morphology1.04516579
98MP0005397_hematopoietic_system_phenotyp1.04309879
99MP0001545_abnormal_hematopoietic_system1.04309879
100MP0004957_abnormal_blastocyst_morpholog1.04268510
101MP0004085_abnormal_heartbeat1.03672278
102MP0002063_abnormal_learning/memory/cond1.03028181
103MP0001485_abnormal_pinna_reflex1.02754121
104MP0004270_analgesia1.02382636
105MP0005310_abnormal_salivary_gland1.02020351
106MP0005503_abnormal_tendon_morphology1.01675886
107MP0002064_seizures1.01128809
108MP0003111_abnormal_nucleus_morphology1.00155522
109MP0002089_abnormal_postnatal_growth/wei0.99836938
110MP0004924_abnormal_behavior0.98586905
111MP0005386_behavior/neurological_phenoty0.98586905
112MP0008775_abnormal_heart_ventricle0.98362244
113MP0002009_preneoplasia0.98314277
114MP0000266_abnormal_heart_morphology0.98287690
115MP0000955_abnormal_spinal_cord0.97825363
116MP0002557_abnormal_social/conspecific_i0.96993661
117MP0000049_abnormal_middle_ear0.96480836
118MP0000470_abnormal_stomach_morphology0.96242597
119MP0005375_adipose_tissue_phenotype0.96074452
120MP0002166_altered_tumor_susceptibility0.95985328
121MP0005620_abnormal_muscle_contractility0.95906586
122MP0000383_abnormal_hair_follicle0.92962612
123MP0008872_abnormal_physiological_respon0.92403490
124MP0000613_abnormal_salivary_gland0.92366241
125MP0004885_abnormal_endolymph0.92051667
126MP0005220_abnormal_exocrine_pancreas0.91406929
127MP0002080_prenatal_lethality0.91086851
128MP0001440_abnormal_grooming_behavior0.90315592
129MP0003937_abnormal_limbs/digits/tail_de0.89552985
130MP0001486_abnormal_startle_reflex0.89218484
131MP0000767_abnormal_smooth_muscle0.88393718
132MP0002638_abnormal_pupillary_reflex0.87857591
133MP0003221_abnormal_cardiomyocyte_apopto0.87843026
134MP0002092_abnormal_eye_morphology0.86691314
135MP0000377_abnormal_hair_follicle0.86381370
136MP0005187_abnormal_penis_morphology0.86236117
137MP0003755_abnormal_palate_morphology0.84581429
138MP0002572_abnormal_emotion/affect_behav0.83782648
139MP0010368_abnormal_lymphatic_system0.83724015
140MP0001293_anophthalmia0.83438540
141MP0006276_abnormal_autonomic_nervous0.83149582
142MP0000534_abnormal_ureter_morphology0.83002362
143MP0003787_abnormal_imprinting0.82924850
144MP0004215_abnormal_myocardial_fiber0.82017326
145MP0003942_abnormal_urinary_system0.80918279
146MP0009672_abnormal_birth_weight0.80916724
147MP0010094_abnormal_chromosome_stability0.80686559
148MP0002108_abnormal_muscle_morphology0.79535219
149MP0001784_abnormal_fluid_regulation0.79429973
150MP0002752_abnormal_somatic_nervous0.79323646
151MP0008770_decreased_survivor_rate0.79322749
152MP0001614_abnormal_blood_vessel0.78715407
153MP0004130_abnormal_muscle_cell0.78703940
154MP0003279_aneurysm0.78173854
155MP0001984_abnormal_olfaction0.78121640
156MP0001177_atelectasis0.77672870
157MP0003861_abnormal_nervous_system0.77336751
158MP0003936_abnormal_reproductive_system0.77157174
159MP0004272_abnormal_basement_membrane0.76260037
160MP0002128_abnormal_blood_circulation0.76041551
161MP0005423_abnormal_somatic_nervous0.75766530
162MP0000516_abnormal_urinary_system0.75592873
163MP0005367_renal/urinary_system_phenotyp0.75592873
164MP0002006_tumorigenesis0.75460495
165MP0005621_abnormal_cell_physiology0.74969267
166MP0002067_abnormal_sensory_capabilities0.74695175
167MP0002882_abnormal_neuron_morphology0.74606005
168MP0002735_abnormal_chemical_nociception0.74391938
169MP0003828_pulmonary_edema0.73755224
170MP0004084_abnormal_cardiac_muscle0.73375504
171MP0002751_abnormal_autonomic_nervous0.72278484
172MP0002019_abnormal_tumor_incidence0.71174050
173MP0002168_other_aberrant_phenotype0.71147404
174MP0002109_abnormal_limb_morphology0.70947377
175MP0005195_abnormal_posterior_eye0.70576930
176MP0000703_abnormal_thymus_morphology0.70184145
177MP0000858_altered_metastatic_potential0.70088182
178MP0005508_abnormal_skeleton_morphology0.69333556
179MP0009115_abnormal_fat_cell0.69060784

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)4.76175172
2Progressive cerebellar ataxia (HP:0002073)3.47668613
3Gaze-evoked nystagmus (HP:0000640)3.41420038
4Congenital stationary night blindness (HP:0007642)3.35137570
5Pancreatic cysts (HP:0001737)3.26110018
6Subacute progressive viral hepatitis (HP:0006572)3.17570781
7Macroorchidism (HP:0000053)3.17302554
8Hyperventilation (HP:0002883)3.13608199
9Protruding tongue (HP:0010808)3.11195881
10Volvulus (HP:0002580)2.89098411
11Heterotopia (HP:0002282)2.88674977
12Abnormality of the fingertips (HP:0001211)2.74989157
13Febrile seizures (HP:0002373)2.70943199
14Pancreatic fibrosis (HP:0100732)2.69715727
15Abnormality of the renal cortex (HP:0011035)2.69588274
16Mitral valve prolapse (HP:0001634)2.68525974
17Fair hair (HP:0002286)2.62183921
18Lip pit (HP:0100267)2.59834267
19Clumsiness (HP:0002312)2.56531961
20Abnormality of midbrain morphology (HP:0002418)2.55989977
21Molar tooth sign on MRI (HP:0002419)2.55989977
22Aortic aneurysm (HP:0004942)2.54079417
23Increased connective tissue (HP:0009025)2.53910727
24Absent frontal sinuses (HP:0002688)2.53729174
25Abnormality of the lower motor neuron (HP:0002366)2.52676737
26Abnormal pancreas size (HP:0012094)2.52284214
27Rectal prolapse (HP:0002035)2.51295921
28Nephronophthisis (HP:0000090)2.50026472
29Chorioretinal atrophy (HP:0000533)2.47842483
30Decreased circulating renin level (HP:0003351)2.47791990
31Abnormality of the renal medulla (HP:0100957)2.47617736
32Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.46206341
33Short 1st metacarpal (HP:0010034)2.46206341
34Broad-based gait (HP:0002136)2.45337265
35Short hallux (HP:0010109)2.45200181
36Tubular atrophy (HP:0000092)2.44909026
37Hepatoblastoma (HP:0002884)2.43727495
38Difficulty running (HP:0009046)2.43634272
39Chronic hepatic failure (HP:0100626)2.43309648
40Hypochromic microcytic anemia (HP:0004840)2.40560975
41Genu recurvatum (HP:0002816)2.34026504
42Abnormality of the astrocytes (HP:0100707)2.31560029
43Astrocytoma (HP:0009592)2.31560029
44Increased density of long bones (HP:0006392)2.31436324
45Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.30280699
46Short 4th metacarpal (HP:0010044)2.30280699
47Cerebral aneurysm (HP:0004944)2.26942062
48Protrusio acetabuli (HP:0003179)2.25282438
49Hypoplastic ischia (HP:0003175)2.23794113
50Aplasia/Hypoplasia of the hallux (HP:0008362)2.22014751
51Papillary thyroid carcinoma (HP:0002895)2.21449415
52Cystic liver disease (HP:0006706)2.20616440
53Shallow orbits (HP:0000586)2.18114812
54Drooling (HP:0002307)2.17020542
55Transitional cell carcinoma of the bladder (HP:0006740)2.16279704
56Broad thumb (HP:0011304)2.16132097
57Abnormality of the renal collecting system (HP:0004742)2.15363184
58Hyperkalemia (HP:0002153)2.15233004
59Aplasia/Hypoplasia of the tibia (HP:0005772)2.13460413
60Disinhibition (HP:0000734)2.13006104
61Bladder carcinoma (HP:0002862)2.12523247
62Bladder neoplasm (HP:0009725)2.12523247
63Generalized hypopigmentation of hair (HP:0011358)2.11564380
64Stomach cancer (HP:0012126)2.10705102
65Abnormality of DNA repair (HP:0003254)2.07430073
66Broad palm (HP:0001169)2.06731430
67Widely spaced teeth (HP:0000687)2.06200592
68Cubitus valgus (HP:0002967)2.04854327
69Abnormality of the proximal phalanges of the hand (HP:0009834)2.04842554
70Absent speech (HP:0001344)2.04575481
71Abnormality of the 1st metacarpal (HP:0010009)2.04136310
72Osteomalacia (HP:0002749)2.04064692
73Malignant gastrointestinal tract tumors (HP:0006749)2.03415291
74Gastrointestinal carcinoma (HP:0002672)2.03415291
75True hermaphroditism (HP:0010459)2.03105965
76Ectopic kidney (HP:0000086)2.02813475
77Congenital sensorineural hearing impairment (HP:0008527)2.01657765
78Dysmetric saccades (HP:0000641)2.00221231
79Morphological abnormality of the middle ear (HP:0008609)1.99763953
80Short phalanx of the thumb (HP:0009660)1.99530214
81Dislocated radial head (HP:0003083)1.98631079
82Ependymoma (HP:0002888)1.98588330
83Male infertility (HP:0003251)1.97416701
842-3 toe syndactyly (HP:0004691)1.96879794
85Short chin (HP:0000331)1.96355975
86Aneurysm (HP:0002617)1.96310310
87Bulbous nose (HP:0000414)1.96193878
88Hypoplastic labia majora (HP:0000059)1.96158742
89Bilateral microphthalmos (HP:0007633)1.95615886
90Severe visual impairment (HP:0001141)1.95003427
91Uterine leiomyosarcoma (HP:0002891)1.94929177
92Leiomyosarcoma (HP:0100243)1.94929177
93Ulnar bowing (HP:0003031)1.93254569
94Wide intermamillary distance (HP:0006610)1.93022933
95Furrowed tongue (HP:0000221)1.92996411
96Excessive salivation (HP:0003781)1.92310032
97Rhabdomyosarcoma (HP:0002859)1.92137379
98Exostoses (HP:0100777)1.91572382
99Type II lissencephaly (HP:0007260)1.91324757
100Neoplasm of striated muscle (HP:0009728)1.90893238
101Abnormality of the labia majora (HP:0012881)1.90705548
102Truncal obesity (HP:0001956)1.89839564
103Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.89724162
104Dilatation of the ascending aorta (HP:0005111)1.89395761
105Fibrous tissue neoplasm (HP:0012316)1.88673949
106Hamartoma of the eye (HP:0010568)1.88255164
107Cerebellar dysplasia (HP:0007033)1.87938331
108Abnormality of the 4th metacarpal (HP:0010012)1.87698664
109Abnormality of the ischium (HP:0003174)1.86230378
110Hematochezia (HP:0002573)1.85899013
111Hyporeflexia of lower limbs (HP:0002600)1.85162942
112Narrow palate (HP:0000189)1.84645220
113Small hand (HP:0200055)1.84395110
114Abnormality of the radial head (HP:0003995)1.83817709
115Fibroma (HP:0010614)1.82897189
116Impaired smooth pursuit (HP:0007772)1.82177898
117Abnormality of the distal phalanx of the thumb (HP:0009617)1.81853154
118Exercise-induced muscle cramps (HP:0003710)1.81739596
119Viral hepatitis (HP:0006562)1.81687986
120Keratoconus (HP:0000563)1.79987683
121Increased corneal curvature (HP:0100692)1.79987683
122Prominent nose (HP:0000448)1.78465020
123Nasal polyposis (HP:0100582)1.77088704
124Abnormal rod and cone electroretinograms (HP:0008323)1.76982929
125Stenosis of the external auditory canal (HP:0000402)1.76629511
126Partial agenesis of the corpus callosum (HP:0001338)1.76418663
127Attenuation of retinal blood vessels (HP:0007843)1.76416225
128Cortical dysplasia (HP:0002539)1.75369749
129Oligodontia (HP:0000677)1.75339489
130Increased number of teeth (HP:0011069)1.74654948
131Persistence of primary teeth (HP:0006335)1.74546570
132Abnormality of the middle phalanges of the toes (HP:0010183)1.73826176
133Duplicated collecting system (HP:0000081)1.73708807
134Synostosis of carpal bones (HP:0005048)1.73488559
135Pendular nystagmus (HP:0012043)1.72751252
136Achilles tendon contracture (HP:0001771)1.72651276
137Hamartoma (HP:0010566)1.71417355
138Increased nuchal translucency (HP:0010880)1.70263671
139Abnormality of the nasal septum (HP:0000419)1.69933881
140Macroglossia (HP:0000158)1.69926622
141Difficulty climbing stairs (HP:0003551)1.69421141
142Lymphangioma (HP:0100764)1.68391755
143Hypopigmentation of the fundus (HP:0007894)1.67889115
144Ankle contracture (HP:0006466)1.67800855
145Resting tremor (HP:0002322)1.66905244
146Mildly elevated creatine phosphokinase (HP:0008180)1.66594674
147Disproportionate tall stature (HP:0001519)1.65436299
148Shawl scrotum (HP:0000049)1.65381052
149Short humerus (HP:0005792)1.64297087
150Central scotoma (HP:0000603)1.63715291
151Spondylolisthesis (HP:0003302)1.63297522
152Vascular tortuosity (HP:0004948)1.62969517
153Broad phalanges of the hand (HP:0009768)1.62830259
154Biliary tract neoplasm (HP:0100574)1.62179774
155Hypoplasia of the uterus (HP:0000013)1.61389820
156Hypoplastic iliac wings (HP:0002866)1.61339841
157Long nose (HP:0003189)1.61300062
158Type 1 muscle fiber predominance (HP:0003803)1.60955400
159Micronodular cirrhosis (HP:0001413)1.60831610
160Rib fusion (HP:0000902)1.60802150
161Curly hair (HP:0002212)1.60587230
162Urinary bladder sphincter dysfunction (HP:0002839)1.60399488
163Abnormality of macular pigmentation (HP:0008002)1.60377394
164Pseudobulbar signs (HP:0002200)1.60172299
165Ankyloglossia (HP:0010296)1.59942094
166Abnormality of chromosome segregation (HP:0002916)1.59842756
167Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.59262701
168Abnormality of the phalanges of the 2nd finger (HP:0009541)1.59222290
169Increased CSF protein (HP:0002922)1.59093480
170Abnormality of chloride homeostasis (HP:0011422)1.58713684
171Abnormality of the columella (HP:0009929)1.58661941
172Arterial tortuosity (HP:0005116)1.58607497
173Neoplasm of the tracheobronchial system (HP:0100552)1.58516377
174Peritonitis (HP:0002586)1.58012718
175Chromosomal breakage induced by crosslinking agents (HP:0003221)1.57810098
176Tented upper lip vermilion (HP:0010804)1.56753944
177Long eyelashes (HP:0000527)1.55941044
178Bony spicule pigmentary retinopathy (HP:0007737)1.55896954
179Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.55733575
180Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.55380317
181Renovascular hypertension (HP:0100817)1.55366355
182Glioma (HP:0009733)1.55296726
183High pitched voice (HP:0001620)1.55128328
184Chromsome breakage (HP:0040012)1.54267541
185Highly arched eyebrow (HP:0002553)1.54117871
186Abnormality of the Achilles tendon (HP:0005109)1.53643199
187Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.53193272
188Amyotrophic lateral sclerosis (HP:0007354)1.52983258
189Aortic dissection (HP:0002647)1.52895359
190Abnormality of the nasal mucosa (HP:0000433)1.52548887
191Camptodactyly of toe (HP:0001836)1.51449892
192Renal duplication (HP:0000075)1.50785723
193Hyperacusis (HP:0010780)1.50034393
194Uterine neoplasm (HP:0010784)1.49288984

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.51531133
2TRIB32.97349701
3STK32.89223123
4LATS12.74527293
5ACVR1B2.74285840
6AKT32.73539527
7STK102.68771797
8PKN22.66642947
9BMPR1B2.64362984
10CASK2.42150766
11MAP3K102.24346930
12RIPK12.23831721
13EEF2K2.05019131
14PTK62.04307718
15SGK21.79877715
16FGFR31.78823008
17PINK11.77783080
18ERN11.74520997
19TTN1.69226102
20DMPK1.67191655
21TYRO31.63410449
22ADRBK21.62402740
23GRK11.58971599
24PDGFRA1.57725523
25TTK1.54865281
26OBSCN1.53001715
27LATS21.52935029
28CDK61.50606135
29MKNK21.42958930
30ALK1.40341788
31STK241.38403223
32TNIK1.32806616
33MARK11.30686492
34CDC71.30579838
35MAP3K41.28582452
36WNK11.27874703
37MELK1.27199636
38NLK1.23596388
39MTOR1.21766243
40RET1.19893399
41SGK2231.18843137
42SGK4941.18843137
43BMX1.16742369
44TAOK11.16072960
45PDGFRB1.14054089
46GRK61.13426036
47NEK21.12536497
48LRRK21.10528670
49PAK31.08896712
50PRKD31.06732562
51DDR21.03313288
52PIK3CA1.02120843
53MAPK131.01897762
54ICK1.01595717
55TGFBR11.00849022
56MAP3K130.99029539
57CAMK1D0.98226755
58MAP3K60.97258199
59CDK40.95621854
60STK38L0.94746535
61FGFR10.93776793
62MAP3K50.93037892
63MAP3K70.92843798
64INSRR0.89332932
65EPHA40.88689120
66TGFBR20.87940428
67PDK40.87762418
68PDK30.87762418
69CAMK1G0.85786350
70NTRK30.85468996
71HIPK20.84196460
72SIK20.84074783
73CSF1R0.80583710
74FRK0.80448309
75MAPKAPK30.80375361
76TAOK30.79896925
77STK390.78663327
78CSK0.78188975
79EPHB10.76993176
80LMTK20.76599913
81CDK90.74169783
82PTK20.72848830
83SCYL20.72800469
84BRSK20.71743978
85CHEK10.70915347
86MAP2K10.70293028
87ADRBK10.69252861
88FGFR20.68774814
89BLK0.67983357
90JAK10.67956005
91CAMKK20.67688844
92MAP3K80.67651122
93PRKAA20.67481261
94KSR20.67479697
95MATK0.66717866
96MAP3K90.65286592
97PNCK0.64527307
98PRKCE0.64220474
99SGK10.63825231
100JAK30.63537167
101TRPM70.63530566
102PIK3CG0.62687596
103RPS6KB10.62336575
104SGK30.61267790
105ATM0.60437486
106EPHA30.59949283
107CAMK40.59820891
108WNK40.59247175
109PLK20.58837000
110CHEK20.58654971
111PAK20.57964896
112JAK20.57262549
113ITK0.56626760
114PIM10.55630504
115PRKCH0.55500945
116NUAK10.55054799
117MAP2K40.54291425
118FER0.53985880
119RPS6KB20.53132058
120CSNK1A1L0.52454453
121MARK20.52277994
122WNK30.51940576
123KSR10.51184072
124PDK10.50782604
125STK380.50045656
126MAPK70.49775459
127DYRK1A0.49725354
128FGFR40.49513393
129PRKD20.49213515
130BRD40.48854931
131NTRK20.48449176
132NEK90.48223119
133MAP2K30.47792532
134DAPK20.47626513
135PRKAA10.47342016
136CSNK1D0.46643635
137IKBKB0.46385905
138RPS6KA60.46285077
139SIK10.46035794
140GSK3A0.45990636
141CDK20.45848313
142FLT30.45093492
143EGFR0.44622962
144MAPK100.44389001
145ERBB30.44074874
146TLK10.44072672
147GRK50.43942904
148CHUK0.43895641
149PRKG20.43495829
150MAPK80.42261679
151GSK3B0.42049345
152PTK2B0.41630529
153PRKCQ0.41070463
154PDK20.40571447
155MARK30.40055595
156PAK40.39825910
157MAP4K10.39580139
158HCK0.39505681
159OXSR10.38937301
160ERBB20.38789684
161TEC0.37985693
162STK110.37791872

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.10904930
2mTOR signaling pathway_Homo sapiens_hsa041502.08978212
3Circadian rhythm_Homo sapiens_hsa047101.84469036
4Dorso-ventral axis formation_Homo sapiens_hsa043201.76501748
5Chronic myeloid leukemia_Homo sapiens_hsa052201.72369189
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.66774606
7MicroRNAs in cancer_Homo sapiens_hsa052061.63720143
8Adherens junction_Homo sapiens_hsa045201.62700910
9Morphine addiction_Homo sapiens_hsa050321.59309874
10Proteoglycans in cancer_Homo sapiens_hsa052051.52375410
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52158997
12Phototransduction_Homo sapiens_hsa047441.50504964
13Pancreatic cancer_Homo sapiens_hsa052121.48360786
14Endometrial cancer_Homo sapiens_hsa052131.45975633
15Small cell lung cancer_Homo sapiens_hsa052221.44172600
16Taste transduction_Homo sapiens_hsa047421.42596002
17Colorectal cancer_Homo sapiens_hsa052101.41869165
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41529955
19Thyroid hormone signaling pathway_Homo sapiens_hsa049191.40537483
20Selenocompound metabolism_Homo sapiens_hsa004501.40504579
21Focal adhesion_Homo sapiens_hsa045101.40295125
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40196358
23Circadian entrainment_Homo sapiens_hsa047131.36090269
24Non-small cell lung cancer_Homo sapiens_hsa052231.33463388
25Calcium signaling pathway_Homo sapiens_hsa040201.32780176
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32379986
27Oxytocin signaling pathway_Homo sapiens_hsa049211.30052328
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.29890253
29Toxoplasmosis_Homo sapiens_hsa051451.29136859
30Hippo signaling pathway_Homo sapiens_hsa043901.28461439
31Glutamatergic synapse_Homo sapiens_hsa047241.28018260
32Cholinergic synapse_Homo sapiens_hsa047251.27036148
33Lysine degradation_Homo sapiens_hsa003101.26677550
34Renal cell carcinoma_Homo sapiens_hsa052111.25344459
35Insulin secretion_Homo sapiens_hsa049111.24422800
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21769709
37Renin secretion_Homo sapiens_hsa049241.21528753
38VEGF signaling pathway_Homo sapiens_hsa043701.20575799
39Viral myocarditis_Homo sapiens_hsa054161.20523502
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.20239168
41Insulin resistance_Homo sapiens_hsa049311.20216157
42Glioma_Homo sapiens_hsa052141.17895389
43B cell receptor signaling pathway_Homo sapiens_hsa046621.17417447
44Gastric acid secretion_Homo sapiens_hsa049711.16688631
45Long-term depression_Homo sapiens_hsa047301.15724563
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15455861
47TGF-beta signaling pathway_Homo sapiens_hsa043501.14779199
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14480768
49Melanoma_Homo sapiens_hsa052181.14095548
50Acute myeloid leukemia_Homo sapiens_hsa052211.13214921
51Prostate cancer_Homo sapiens_hsa052151.12290778
52FoxO signaling pathway_Homo sapiens_hsa040681.11994929
53Longevity regulating pathway - mammal_Homo sapiens_hsa042111.11956393
54Vascular smooth muscle contraction_Homo sapiens_hsa042701.11911792
55Leukocyte transendothelial migration_Homo sapiens_hsa046701.11588943
56cAMP signaling pathway_Homo sapiens_hsa040241.10260433
57Hedgehog signaling pathway_Homo sapiens_hsa043401.10081591
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09974650
59Serotonergic synapse_Homo sapiens_hsa047261.09751615
60Central carbon metabolism in cancer_Homo sapiens_hsa052301.09311640
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09254126
62ABC transporters_Homo sapiens_hsa020101.08243897
63GABAergic synapse_Homo sapiens_hsa047271.08147009
64Ovarian steroidogenesis_Homo sapiens_hsa049131.06749944
65Prolactin signaling pathway_Homo sapiens_hsa049171.06746103
66AMPK signaling pathway_Homo sapiens_hsa041521.06589192
67Cell cycle_Homo sapiens_hsa041101.06235564
68cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05147890
69Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05122011
70Basal transcription factors_Homo sapiens_hsa030221.04600349
71Regulation of actin cytoskeleton_Homo sapiens_hsa048101.04578406
72Osteoclast differentiation_Homo sapiens_hsa043801.04421942
73Olfactory transduction_Homo sapiens_hsa047401.04047285
74T cell receptor signaling pathway_Homo sapiens_hsa046601.03536507
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03371255
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02086295
77Hepatitis B_Homo sapiens_hsa051611.01580797
78TNF signaling pathway_Homo sapiens_hsa046681.00076418
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99574905
80Viral carcinogenesis_Homo sapiens_hsa052030.99559450
81HTLV-I infection_Homo sapiens_hsa051660.98464552
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97983702
83Axon guidance_Homo sapiens_hsa043600.96910937
84Salivary secretion_Homo sapiens_hsa049700.95963722
85mRNA surveillance pathway_Homo sapiens_hsa030150.95802340
86ECM-receptor interaction_Homo sapiens_hsa045120.95544206
87Linoleic acid metabolism_Homo sapiens_hsa005910.94276688
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.93809683
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.92143640
90Leishmaniasis_Homo sapiens_hsa051400.91991522
91Choline metabolism in cancer_Homo sapiens_hsa052310.91613485
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91523110
93Nitrogen metabolism_Homo sapiens_hsa009100.91451675
94Estrogen signaling pathway_Homo sapiens_hsa049150.89926992
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.89740503
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89122277
97Thyroid cancer_Homo sapiens_hsa052160.89054248
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89041220
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88352388
100Platelet activation_Homo sapiens_hsa046110.87733927
101Amoebiasis_Homo sapiens_hsa051460.85665260
102Apoptosis_Homo sapiens_hsa042100.85270882
103MAPK signaling pathway_Homo sapiens_hsa040100.84887272
104Dopaminergic synapse_Homo sapiens_hsa047280.83745133
105Fatty acid biosynthesis_Homo sapiens_hsa000610.83495249
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83274273
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82468532
108Pathways in cancer_Homo sapiens_hsa052000.82075439
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81636771
110Basal cell carcinoma_Homo sapiens_hsa052170.80535786
111ErbB signaling pathway_Homo sapiens_hsa040120.80456431
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80305630
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79388859
114Long-term potentiation_Homo sapiens_hsa047200.78884152
115Type II diabetes mellitus_Homo sapiens_hsa049300.78735788
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.78044558
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.77076856
118Bladder cancer_Homo sapiens_hsa052190.76952691
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76516042
120Melanogenesis_Homo sapiens_hsa049160.76465318
121Insulin signaling pathway_Homo sapiens_hsa049100.76371851
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75466694
123Rap1 signaling pathway_Homo sapiens_hsa040150.74348724
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.74248948
125Notch signaling pathway_Homo sapiens_hsa043300.73803108
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73597109
127Wnt signaling pathway_Homo sapiens_hsa043100.73398488
128Dilated cardiomyopathy_Homo sapiens_hsa054140.72456002
129Tight junction_Homo sapiens_hsa045300.71920325
130HIF-1 signaling pathway_Homo sapiens_hsa040660.71107294
131Endocytosis_Homo sapiens_hsa041440.70905281
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70421294
133p53 signaling pathway_Homo sapiens_hsa041150.69386044
134Ras signaling pathway_Homo sapiens_hsa040140.68885689
135Inositol phosphate metabolism_Homo sapiens_hsa005620.68487795
136Herpes simplex infection_Homo sapiens_hsa051680.67444175
137Oocyte meiosis_Homo sapiens_hsa041140.67146774
138Regulation of autophagy_Homo sapiens_hsa041400.66895144
139Chemokine signaling pathway_Homo sapiens_hsa040620.66414535
140Amphetamine addiction_Homo sapiens_hsa050310.65704039
141GnRH signaling pathway_Homo sapiens_hsa049120.65428933
142Glucagon signaling pathway_Homo sapiens_hsa049220.64987781
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64857165
144Antigen processing and presentation_Homo sapiens_hsa046120.64576406
145Influenza A_Homo sapiens_hsa051640.64109057
146Measles_Homo sapiens_hsa051620.63863280
147Ether lipid metabolism_Homo sapiens_hsa005650.63673142
148NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61997773
149Gap junction_Homo sapiens_hsa045400.61757282
150Cocaine addiction_Homo sapiens_hsa050300.59931191
151Hepatitis C_Homo sapiens_hsa051600.59424509
152Pancreatic secretion_Homo sapiens_hsa049720.58617900
153Sphingolipid signaling pathway_Homo sapiens_hsa040710.57145423
154Shigellosis_Homo sapiens_hsa051310.56586541
155RNA degradation_Homo sapiens_hsa030180.56433142
156Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55462132
157Histidine metabolism_Homo sapiens_hsa003400.54144945
158Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52543577
159Glycerolipid metabolism_Homo sapiens_hsa005610.51553879

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