ARIH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some cancer cells and may inhibit myelopoiesis. Several transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been determined yet. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)5.71904774
2purine nucleobase biosynthetic process (GO:0009113)5.60108430
3ribosome assembly (GO:0042255)5.50881317
4nucleobase biosynthetic process (GO:0046112)5.13746985
5meiotic chromosome segregation (GO:0045132)4.97211150
6mitotic metaphase plate congression (GO:0007080)4.71833325
7folic acid metabolic process (GO:0046655)4.69565636
8ribosome biogenesis (GO:0042254)4.53618114
9regulation of spindle organization (GO:0090224)4.38108779
10chromosome organization involved in meiosis (GO:0070192)4.38027912
11male meiosis I (GO:0007141)4.34266943
12regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.22944307
13DNA replication checkpoint (GO:0000076)4.22343078
14piRNA metabolic process (GO:0034587)4.20013087
15vitamin transmembrane transport (GO:0035461)4.08207653
16formation of translation preinitiation complex (GO:0001731)4.07631468
17DNA synthesis involved in DNA repair (GO:0000731)4.01092903
18nuclear pore organization (GO:0006999)3.96422744
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.92420445
20somatic hypermutation of immunoglobulin genes (GO:0016446)3.87388036
21somatic diversification of immune receptors via somatic mutation (GO:0002566)3.87388036
22regulation of translation in response to stress (GO:0043555)3.85477858
23mitotic sister chromatid cohesion (GO:0007064)3.82188367
24rRNA modification (GO:0000154)3.75964073
25DNA methylation involved in gamete generation (GO:0043046)3.73802330
26DNA unwinding involved in DNA replication (GO:0006268)3.73336530
27positive regulation of chromosome segregation (GO:0051984)3.67277636
28folic acid transport (GO:0015884)3.66678270
29IMP metabolic process (GO:0046040)3.66653454
30mitotic nuclear envelope disassembly (GO:0007077)3.64592818
31metaphase plate congression (GO:0051310)3.62797265
32sister chromatid cohesion (GO:0007062)3.57214421
33termination of RNA polymerase I transcription (GO:0006363)3.56385261
34meiotic nuclear division (GO:0007126)3.54488079
35nuclear pore complex assembly (GO:0051292)3.52692894
36DNA replication initiation (GO:0006270)3.52688689
37protein localization to kinetochore (GO:0034501)3.52159633
38non-recombinational repair (GO:0000726)3.49583259
39double-strand break repair via nonhomologous end joining (GO:0006303)3.49583259
40transcription elongation from RNA polymerase I promoter (GO:0006362)3.49296049
41regulation of mitotic spindle organization (GO:0060236)3.47771600
42protein K6-linked ubiquitination (GO:0085020)3.45218008
43ribonucleoprotein complex biogenesis (GO:0022613)3.44054364
44regulation of translational fidelity (GO:0006450)3.41438283
45reciprocal DNA recombination (GO:0035825)3.41391637
46reciprocal meiotic recombination (GO:0007131)3.41391637
47regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.40420835
48regulation of mitotic spindle checkpoint (GO:1903504)3.40420835
49male meiosis (GO:0007140)3.40384468
50transcription from RNA polymerase I promoter (GO:0006360)3.39791037
51intestinal epithelial cell development (GO:0060576)3.38976430
52nuclear envelope disassembly (GO:0051081)3.38608392
53membrane disassembly (GO:0030397)3.38608392
54transcription elongation from RNA polymerase III promoter (GO:0006385)3.37753579
55termination of RNA polymerase III transcription (GO:0006386)3.37753579
56synaptonemal complex organization (GO:0070193)3.37593998
57telomere maintenance via semi-conservative replication (GO:0032201)3.37582710
58histone H2A acetylation (GO:0043968)3.37086989
59maturation of SSU-rRNA (GO:0030490)3.34486661
60negative regulation of translational initiation (GO:0045947)3.32508535
61blastocyst development (GO:0001824)3.30549597
62resolution of meiotic recombination intermediates (GO:0000712)3.29047790
63protein localization to chromosome, centromeric region (GO:0071459)3.26582688
64DNA deamination (GO:0045006)3.24478395
65meiotic cell cycle process (GO:1903046)3.21322793
66regulation of mitochondrial translation (GO:0070129)3.20863856
67rRNA processing (GO:0006364)3.19210680
68proteasome assembly (GO:0043248)3.19200493
69transcription initiation from RNA polymerase I promoter (GO:0006361)3.19002143
70DNA replication-dependent nucleosome organization (GO:0034723)3.18293483
71DNA replication-dependent nucleosome assembly (GO:0006335)3.18293483
72regulation of nuclear cell cycle DNA replication (GO:0033262)3.17994812
73mitotic chromosome condensation (GO:0007076)3.15795582
74glycine metabolic process (GO:0006544)3.13499807
75pore complex assembly (GO:0046931)3.11714371
76interferon-gamma secretion (GO:0072643)3.11378808
77rRNA metabolic process (GO:0016072)3.11378738
78pseudouridine synthesis (GO:0001522)3.09096621
79regulation of chromosome segregation (GO:0051983)3.08963400
80inner cell mass cell proliferation (GO:0001833)3.08066690
81anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.07822114
82GMP metabolic process (GO:0046037)3.06604112
83rRNA methylation (GO:0031167)3.05917480
84spindle checkpoint (GO:0031577)3.02719339
85tRNA aminoacylation for protein translation (GO:0006418)3.01084837
86regulation of double-strand break repair via homologous recombination (GO:0010569)3.00915964
87negative regulation of chromosome segregation (GO:0051985)3.00763911
88sister chromatid segregation (GO:0000819)3.00286372
89regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.00054243
90aspartate family amino acid catabolic process (GO:0009068)2.99965372
91tRNA aminoacylation (GO:0043039)2.97663680
92amino acid activation (GO:0043038)2.97663680
93DNA strand elongation involved in DNA replication (GO:0006271)2.97550033
94telomere maintenance via recombination (GO:0000722)2.97232722
95mitotic spindle checkpoint (GO:0071174)2.95512425
96regulation of histone H3-K27 methylation (GO:0061085)2.94735747
97L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.93495004
98positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.93277526
99maturation of 5.8S rRNA (GO:0000460)2.93190945
100regulation of centrosome cycle (GO:0046605)2.93071389
101negative regulation of mitotic sister chromatid separation (GO:2000816)2.92591528
102negative regulation of mitotic sister chromatid segregation (GO:0033048)2.92591528
103negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.92591528
104negative regulation of sister chromatid segregation (GO:0033046)2.92591528
105IMP biosynthetic process (GO:0006188)2.92281755
106ribosomal large subunit biogenesis (GO:0042273)2.92009233
107establishment of chromosome localization (GO:0051303)2.91791743
108spliceosomal snRNP assembly (GO:0000387)2.91629119
109lung-associated mesenchyme development (GO:0060484)2.91376423
110nuclear envelope organization (GO:0006998)2.90915310
111regulation of mitotic metaphase/anaphase transition (GO:0030071)2.90667518
112mitotic recombination (GO:0006312)2.87355758
1137-methylguanosine mRNA capping (GO:0006370)2.86795624
114negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.85095894
115pantothenate metabolic process (GO:0015939)2.85095135
116lysine catabolic process (GO:0006554)2.84896992
117lysine metabolic process (GO:0006553)2.84896992
118mitotic sister chromatid segregation (GO:0000070)2.84159771
119DNA strand elongation (GO:0022616)2.84123267
120attachment of spindle microtubules to kinetochore (GO:0008608)2.83121313
121peptidyl-histidine modification (GO:0018202)2.82429502
122mitotic spindle assembly checkpoint (GO:0007094)2.82156452
123regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.82141718
124negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81501551
125muscle filament sliding (GO:0030049)2.81464134
126actin-myosin filament sliding (GO:0033275)2.81464134
127chromatin remodeling at centromere (GO:0031055)2.81057572
128monoubiquitinated protein deubiquitination (GO:0035520)2.80720391
129negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.79026423
130folic acid-containing compound biosynthetic process (GO:0009396)2.78889520
131spindle assembly checkpoint (GO:0071173)2.78244671
132synaptonemal complex assembly (GO:0007130)2.76552112
1337-methylguanosine RNA capping (GO:0009452)2.75732924
134RNA capping (GO:0036260)2.75732924
135regulation of translational termination (GO:0006449)2.75297927
136inner mitochondrial membrane organization (GO:0007007)2.74656589
137regulation of G0 to G1 transition (GO:0070316)2.74086186
138mitochondrial RNA metabolic process (GO:0000959)2.74053794
139positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.72767455
140regulation of RNA export from nucleus (GO:0046831)2.72628558
141meiosis I (GO:0007127)2.69407276
142DNA-dependent DNA replication (GO:0006261)2.69390949
143regulation of mitotic sister chromatid separation (GO:0010965)2.68495922
144regulation of mitotic sister chromatid segregation (GO:0033047)2.68495922
145regulation of sister chromatid segregation (GO:0033045)2.68495922
146DNA-templated transcription, elongation (GO:0006354)2.68409553
147regulation of spindle checkpoint (GO:0090231)2.68061429
148positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.66950182
149ubiquinone biosynthetic process (GO:0006744)2.66298259
150CENP-A containing nucleosome assembly (GO:0034080)2.65740843
151telomere maintenance via telomere lengthening (GO:0010833)2.65553238
152negative regulation of cell cycle G2/M phase transition (GO:1902750)2.64927713
153tRNA methylation (GO:0030488)2.64671045
154histone exchange (GO:0043486)2.63758414
155establishment of integrated proviral latency (GO:0075713)2.61935205
156regulation of DNA endoreduplication (GO:0032875)2.60840297
157regulation of translational elongation (GO:0006448)2.60246842

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.48426236
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.60331536
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.59211702
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.38536048
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.20656009
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.94060082
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82050877
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.79375714
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.73387787
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.71117910
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.70257933
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.66372061
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55856330
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51956863
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.47199297
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.45632387
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.43528420
18NANOG_18555785_ChIP-Seq_MESCs_Mouse2.25024285
19VDR_23849224_ChIP-Seq_CD4+_Human2.14984394
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13901934
21AR_21909140_ChIP-Seq_LNCAP_Human2.09464383
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03163365
23POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.95054463
24SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.91701813
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86283226
26XRN2_22483619_ChIP-Seq_HELA_Human1.85109004
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.84767742
28GABP_19822575_ChIP-Seq_HepG2_Human1.80533986
29* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79996010
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.79276088
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76587513
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.74001187
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70443712
34DCP1A_22483619_ChIP-Seq_HELA_Human1.67371908
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.66515761
36FOXP3_21729870_ChIP-Seq_TREG_Human1.66393728
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.64539645
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63916333
39* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63051749
40KDM5A_27292631_Chip-Seq_BREAST_Human1.58282876
41ZNF263_19887448_ChIP-Seq_K562_Human1.56971139
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55504333
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.55008038
44MYC_18940864_ChIP-ChIP_HL60_Human1.54557295
45* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.51696981
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50816941
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.43273991
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.43273991
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.43273991
50KLF4_18555785_ChIP-Seq_MESCs_Mouse1.42161038
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36105165
52TTF2_22483619_ChIP-Seq_HELA_Human1.35942077
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.34644848
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33326581
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.32857530
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30992806
57* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29234474
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28637102
59CIITA_25753668_ChIP-Seq_RAJI_Human1.26375250
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.26133090
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25683606
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24401491
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23869033
64* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23743077
65ELK1_19687146_ChIP-ChIP_HELA_Human1.20344053
66ZNF274_21170338_ChIP-Seq_K562_Hela1.20257490
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19744614
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17899331
69* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17535071
70MYC_22102868_ChIP-Seq_BL_Human1.15966663
71* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15908619
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13709356
73* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13623478
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12740400
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11780292
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11154344
77TFEB_21752829_ChIP-Seq_HELA_Human1.09746012
78PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07271738
79CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07067313
80NANOG_21062744_ChIP-ChIP_HESCs_Human1.06248302
81SRF_21415370_ChIP-Seq_HL-1_Mouse1.06126429
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05033201
83ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04786685
84* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.04758026
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04544488
86* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03459576
87TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02125864
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00983134
89* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00334394
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00194747
91SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98680229
92IRF1_19129219_ChIP-ChIP_H3396_Human0.97524280
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97367551
94* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96240774
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95582666
96* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94880931
97PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94845783
98SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94545781
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94276414
100NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94050911
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92441826
102PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92376124
103KAP1_22055183_ChIP-Seq_ESCs_Mouse0.90897668
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90823423
105GATA4_21415370_ChIP-Seq_HL-1_Mouse0.90768104
106* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.90299122
107ELK1_22589737_ChIP-Seq_MCF10A_Human0.90216134
108KAP1_27257070_Chip-Seq_ESCs_Mouse0.90097003
109SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89412409
110FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89315210
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88927336
112EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.88853728
113* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88603840
114* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88044932
115IGF1R_20145208_ChIP-Seq_DFB_Human0.87370109
116* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.87143158
117CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87004009
118* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.85816514
119CHD1_26751641_Chip-Seq_LNCaP_Human0.82577014
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80640572
121FOXP1_21924763_ChIP-Seq_HESCs_Human0.78497040
122CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.71128827
123MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.70639382
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.69135674
125TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.68372643
126SOX17_20123909_ChIP-Seq_XEN_Mouse0.68215544

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.63503373
2MP0003111_abnormal_nucleus_morphology4.51594212
3MP0004957_abnormal_blastocyst_morpholog3.74723300
4MP0010094_abnormal_chromosome_stability3.56981405
5MP0008057_abnormal_DNA_replication3.43029045
6MP0003077_abnormal_cell_cycle3.40740132
7MP0008260_abnormal_autophagy3.06464121
8MP0000749_muscle_degeneration3.05486495
9MP0008058_abnormal_DNA_repair3.03389503
10MP0009840_abnormal_foam_cell2.84106845
11MP0003718_maternal_effect2.73193515
12MP0002837_dystrophic_cardiac_calcinosis2.71826829
13MP0004036_abnormal_muscle_relaxation2.48106179
14MP0004233_abnormal_muscle_weight2.46305241
15MP0000751_myopathy2.41024720
16MP0003786_premature_aging2.36857705
17MP0006036_abnormal_mitochondrial_physio2.36770934
18MP0001730_embryonic_growth_arrest2.18449468
19MP0004145_abnormal_muscle_electrophysio2.17332516
20MP0010307_abnormal_tumor_latency2.13558607
21MP0003136_yellow_coat_color2.08675649
22MP0008007_abnormal_cellular_replicative2.04425201
23MP0010352_gastrointestinal_tract_polyps2.03467584
24MP0008932_abnormal_embryonic_tissue1.94724333
25MP0005330_cardiomyopathy1.89662559
26MP0000350_abnormal_cell_proliferation1.88195505
27MP0005380_embryogenesis_phenotype1.85034746
28MP0001672_abnormal_embryogenesis/_devel1.85034746
29MP0008995_early_reproductive_senescence1.69811186
30MP0003984_embryonic_growth_retardation1.61122518
31MP0002088_abnormal_embryonic_growth/wei1.59545090
32MP0004215_abnormal_myocardial_fiber1.57683030
33MP0008877_abnormal_DNA_methylation1.57213126
34MP0004087_abnormal_muscle_fiber1.57050642
35MP0002396_abnormal_hematopoietic_system1.56938208
36MP0009697_abnormal_copulation1.54369412
37MP0009333_abnormal_splenocyte_physiolog1.54246744
38MP0003123_paternal_imprinting1.50874656
39MP0001661_extended_life_span1.50537828
40MP0005397_hematopoietic_system_phenotyp1.48660107
41MP0001545_abnormal_hematopoietic_system1.48660107
42MP0001697_abnormal_embryo_size1.46951056
43MP0002106_abnormal_muscle_physiology1.46018355
44MP0002080_prenatal_lethality1.45726059
45MP0003806_abnormal_nucleotide_metabolis1.44176345
46MP0002086_abnormal_extraembryonic_tissu1.40855363
47MP0000747_muscle_weakness1.39039291
48MP0002210_abnormal_sex_determination1.38249841
49MP0009278_abnormal_bone_marrow1.38036449
50MP0005451_abnormal_body_composition1.36485012
51MP0001929_abnormal_gametogenesis1.36285324
52MP0000759_abnormal_skeletal_muscle1.35454796
53MP0003878_abnormal_ear_physiology1.34089918
54MP0005377_hearing/vestibular/ear_phenot1.34089918
55MP0000372_irregular_coat_pigmentation1.27880640
56MP0005369_muscle_phenotype1.26968814
57MP0001145_abnormal_male_reproductive1.24268252
58MP0000490_abnormal_crypts_of1.22960380
59MP0004147_increased_porphyrin_level1.22536147
60MP0005076_abnormal_cell_differentiation1.22120065
61MP0002085_abnormal_embryonic_tissue1.21493471
62MP0000313_abnormal_cell_death1.19693568
63MP0003567_abnormal_fetal_cardiomyocyte1.16422969
64MP0002019_abnormal_tumor_incidence1.16277395
65MP0004130_abnormal_muscle_cell1.14281451
66MP0004197_abnormal_fetal_growth/weight/1.13300126
67MP0002084_abnormal_developmental_patter1.13250325
68MP0005410_abnormal_fertilization1.12755010
69MP0005670_abnormal_white_adipose1.11935095
70MP0004808_abnormal_hematopoietic_stem1.11262863
71MP0005395_other_phenotype1.10145922
72MP0000750_abnormal_muscle_regeneration1.08225652
73MP0003221_abnormal_cardiomyocyte_apopto1.03976567
74MP0000358_abnormal_cell_content/1.02911186
75MP0010630_abnormal_cardiac_muscle1.02268397
76MP0005266_abnormal_metabolism1.01699071
77MP0000653_abnormal_sex_gland0.99688418
78MP0005620_abnormal_muscle_contractility0.98665571
79MP0001542_abnormal_bone_strength0.98519770
80MP0004019_abnormal_vitamin_homeostasis0.95243047
81MP0009672_abnormal_birth_weight0.92390499
82MP0005621_abnormal_cell_physiology0.91075014
83MP0008775_abnormal_heart_ventricle0.90326357
84MP0000627_abnormal_mammary_gland0.89838200
85MP0003698_abnormal_male_reproductive0.89209083
86MP0003890_abnormal_embryonic-extraembry0.87926683
87MP0002722_abnormal_immune_system0.87556056
88MP0003186_abnormal_redox_activity0.87065381
89MP0002102_abnormal_ear_morphology0.86761543
90MP0006072_abnormal_retinal_apoptosis0.85797687
91MP0002972_abnormal_cardiac_muscle0.84537526
92MP0000689_abnormal_spleen_morphology0.84485213
93MP0005384_cellular_phenotype0.84337929
94MP0005389_reproductive_system_phenotype0.80948782
95MP0001529_abnormal_vocalization0.80240285
96MP0002332_abnormal_exercise_endurance0.79229730
97MP0003448_altered_tumor_morphology0.78940048
98MP0006138_congestive_heart_failure0.78862822
99MP0002398_abnormal_bone_marrow0.78378657
100MP0000703_abnormal_thymus_morphology0.78179650
101MP0000371_diluted_coat_color0.77373354
102MP0003763_abnormal_thymus_physiology0.75719288
103MP0002269_muscular_atrophy0.75601513
104MP0005058_abnormal_lysosome_morphology0.74926956
105MP0002108_abnormal_muscle_morphology0.74385660
106MP0006292_abnormal_olfactory_placode0.74370378
107MP0001764_abnormal_homeostasis0.73638498
108MP0005075_abnormal_melanosome_morpholog0.73404069
109MP0001293_anophthalmia0.72539596
110MP0003315_abnormal_perineum_morphology0.72460426
111MP0002161_abnormal_fertility/fecundity0.72132673
112MP0004185_abnormal_adipocyte_glucose0.72081516
113MP0000609_abnormal_liver_physiology0.71762952
114MP0003937_abnormal_limbs/digits/tail_de0.70892503
115MP0005023_abnormal_wound_healing0.70695432
116MP0010030_abnormal_orbit_morphology0.70501938
117MP0003941_abnormal_skin_development0.69623997
118MP0005645_abnormal_hypothalamus_physiol0.69436851
119MP0001299_abnormal_eye_distance/0.68819718
120MP0001544_abnormal_cardiovascular_syste0.68361886
121MP0005385_cardiovascular_system_phenoty0.68361886
122MP0009703_decreased_birth_body0.68324270
123MP0002160_abnormal_reproductive_system0.67905300
124MP0001119_abnormal_female_reproductive0.66559665
125MP0004947_skin_inflammation0.66451770
126MP0002429_abnormal_blood_cell0.66135843
127MP0005671_abnormal_response_to0.65024757
128MP0003646_muscle_fatigue0.64844902
129MP0001727_abnormal_embryo_implantation0.64730925
130MP0003936_abnormal_reproductive_system0.64399869
131MP0002009_preneoplasia0.63858349
132MP0006035_abnormal_mitochondrial_morpho0.63592709
133MP0003119_abnormal_digestive_system0.63511742
134MP0003137_abnormal_impulse_conducting0.63403003
135MP0003436_decreased_susceptibility_to0.63089298
136MP0003699_abnormal_female_reproductive0.62970305
137MP0000858_altered_metastatic_potential0.62584456
138MP0008770_decreased_survivor_rate0.62468235
139MP0001853_heart_inflammation0.62335859
140MP0002132_abnormal_respiratory_system0.61893464
141MP0001756_abnormal_urination0.61872110
142MP0003303_peritoneal_inflammation0.61795211
143MP0000716_abnormal_immune_system0.60471770
144MP0004084_abnormal_cardiac_muscle0.60439434
145MP0002127_abnormal_cardiovascular_syste0.59261657

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.46588634
2Breast hypoplasia (HP:0003187)5.25384506
3Impulsivity (HP:0100710)4.54207255
4Muscle fiber inclusion bodies (HP:0100299)4.32881222
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.25146469
6Nemaline bodies (HP:0003798)4.14591627
7Rimmed vacuoles (HP:0003805)4.11718663
8Carpal bone hypoplasia (HP:0001498)3.94728558
9Exercise-induced myalgia (HP:0003738)3.85452527
10Hyperglycinemia (HP:0002154)3.82790890
11Rough bone trabeculation (HP:0100670)3.60776368
12Ureteral duplication (HP:0000073)3.53832787
13Cerebral hypomyelination (HP:0006808)3.50679585
14Exercise-induced muscle cramps (HP:0003710)3.43478910
15Hyperglycinuria (HP:0003108)3.37516535
16Patellar aplasia (HP:0006443)3.29492954
17Aplasia/Hypoplasia of the patella (HP:0006498)3.22579879
18Entropion (HP:0000621)3.21188613
19Abnormality of the anterior horn cell (HP:0006802)3.16368665
20Degeneration of anterior horn cells (HP:0002398)3.16368665
21Progressive muscle weakness (HP:0003323)3.09783724
22Muscle hypertrophy of the lower extremities (HP:0008968)2.99314053
23Pustule (HP:0200039)2.89305949
24Colon cancer (HP:0003003)2.87926166
25Absent radius (HP:0003974)2.81273670
26Abnormality of the umbilical cord (HP:0010881)2.77941370
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.76960022
28Premature ovarian failure (HP:0008209)2.74584475
29Microvesicular hepatic steatosis (HP:0001414)2.72923262
30Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.71695353
31Calf muscle hypertrophy (HP:0008981)2.71460564
32Myopathic facies (HP:0002058)2.69970090
33Myoglobinuria (HP:0002913)2.69842221
34Ragged-red muscle fibers (HP:0003200)2.66757822
35Hypoplasia of the capital femoral epiphysis (HP:0003090)2.63591131
36Oral leukoplakia (HP:0002745)2.63228270
37Abnormal trabecular bone morphology (HP:0100671)2.61388417
38Centrally nucleated skeletal muscle fibers (HP:0003687)2.61079615
39Absent forearm bone (HP:0003953)2.60516838
40Aplasia involving forearm bones (HP:0009822)2.60516838
41EMG: myopathic abnormalities (HP:0003458)2.59633365
42Abnormality of the preputium (HP:0100587)2.54902773
43Meckel diverticulum (HP:0002245)2.54172874
44Abnormality of serine family amino acid metabolism (HP:0010894)2.54051923
45Abnormality of glycine metabolism (HP:0010895)2.54051923
46Rhabdomyolysis (HP:0003201)2.53209627
47Secondary amenorrhea (HP:0000869)2.50798922
48Abnormality of the labia minora (HP:0012880)2.50757066
49Testicular atrophy (HP:0000029)2.49598348
50Multiple enchondromatosis (HP:0005701)2.48725755
51Abnormal spermatogenesis (HP:0008669)2.47297652
52Ependymoma (HP:0002888)2.47254275
53Muscle fiber splitting (HP:0003555)2.46383601
54Selective tooth agenesis (HP:0001592)2.46381066
55Chromsome breakage (HP:0040012)2.44361664
56Abnormality of the distal phalanges of the toes (HP:0010182)2.42025147
57Gout (HP:0001997)2.38159352
58Areflexia of lower limbs (HP:0002522)2.37382778
59Abnormality of serum amino acid levels (HP:0003112)2.36755988
60Abnormality of the ileum (HP:0001549)2.36097867
61Personality changes (HP:0000751)2.35631168
62Difficulty climbing stairs (HP:0003551)2.34388025
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.34185566
64Abnormality of chromosome stability (HP:0003220)2.33101814
65Absent thumb (HP:0009777)2.30885051
66Pelvic girdle muscle weakness (HP:0003749)2.30876387
67Irregular epiphyses (HP:0010582)2.30801117
68Prominent nose (HP:0000448)2.30474785
69Bone marrow hypocellularity (HP:0005528)2.25965119
70Decreased activity of mitochondrial respiratory chain (HP:0008972)2.24268761
71Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.24268761
72Absent epiphyses (HP:0010577)2.22365924
73Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.22365924
74Atrioventricular block (HP:0001678)2.21530120
75Type 1 muscle fiber predominance (HP:0003803)2.21394323
76Trismus (HP:0000211)2.20703875
77Astrocytoma (HP:0009592)2.18924811
78Abnormality of the astrocytes (HP:0100707)2.18924811
79Microretrognathia (HP:0000308)2.18693140
80Prolonged neonatal jaundice (HP:0006579)2.18451690
81Spinal muscular atrophy (HP:0007269)2.15302722
82Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.14256569
83Abnormal protein N-linked glycosylation (HP:0012347)2.14256569
84Abnormal protein glycosylation (HP:0012346)2.14256569
85Abnormal glycosylation (HP:0012345)2.14256569
86Aplasia/hypoplasia of the humerus (HP:0006507)2.13016504
87Sparse eyelashes (HP:0000653)2.12503100
88Stillbirth (HP:0003826)2.12455618
89Type I transferrin isoform profile (HP:0003642)2.12274208
90Abnormality of the calf musculature (HP:0001430)2.12194796
91Death in infancy (HP:0001522)2.11939991
92Hypoplasia of the pons (HP:0012110)2.10573740
93Gonadotropin excess (HP:0000837)2.08905781
94Ectopic kidney (HP:0000086)2.08756653
95Neoplasm of the pancreas (HP:0002894)2.08680788
96Poor eye contact (HP:0000817)2.05709839
97Aplasia/Hypoplasia involving the musculature (HP:0001460)2.05610291
98Bundle branch block (HP:0011710)2.05586435
99Sparse lateral eyebrow (HP:0005338)2.04340885
100Tetraplegia (HP:0002445)2.03660088
101Abnormality of alanine metabolism (HP:0010916)2.02198215
102Hyperalaninemia (HP:0003348)2.02198215
103Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02198215
104Duplicated collecting system (HP:0000081)2.01398480
105Small epiphyses (HP:0010585)2.01134238
106Hyperglycemia (HP:0003074)2.00764368
107Distal arthrogryposis (HP:0005684)2.00651691
108CNS hypomyelination (HP:0003429)2.00535884
109Tubulointerstitial nephritis (HP:0001970)1.99559178
110Abnormality of the pons (HP:0007361)1.98967716
111Megaloblastic anemia (HP:0001889)1.97983299
112Increased serum lactate (HP:0002151)1.97915639
113Abnormality of the left ventricular outflow tract (HP:0011103)1.97826463
114Subaortic stenosis (HP:0001682)1.97826463
115Calcaneovalgus deformity (HP:0001848)1.97816586
116Anal stenosis (HP:0002025)1.96706327
117Reduced subcutaneous adipose tissue (HP:0003758)1.96080110
118Volvulus (HP:0002580)1.95469827
119Shoulder girdle muscle weakness (HP:0003547)1.95237367
120Breast aplasia (HP:0100783)1.91626423
121Duodenal stenosis (HP:0100867)1.91413217
122Small intestinal stenosis (HP:0012848)1.91413217
123Short nail (HP:0001799)1.90793412
124Abnormality of DNA repair (HP:0003254)1.89966920
125Hyperinsulinemic hypoglycemia (HP:0000825)1.89468906
126Hepatocellular necrosis (HP:0001404)1.89360823
127Squamous cell carcinoma (HP:0002860)1.89123311
128Hypoplasia of the radius (HP:0002984)1.88082923
129Absent hand (HP:0004050)1.87159493
130Increased CSF lactate (HP:0002490)1.86257763
131Abnormality of the musculature of the pelvis (HP:0001469)1.86034058
132Abnormality of the hip-girdle musculature (HP:0001445)1.86034058
133Azoospermia (HP:0000027)1.85827001
134Myelodysplasia (HP:0002863)1.85754745
135Exercise intolerance (HP:0003546)1.85228847
136Sloping forehead (HP:0000340)1.84100533
137Hepatic necrosis (HP:0002605)1.83579809
138Atrophy/Degeneration involving motor neurons (HP:0007373)1.83315154
139Progressive external ophthalmoplegia (HP:0000590)1.83211013
140Pancreatic islet-cell hyperplasia (HP:0004510)1.82429922
141Congenital, generalized hypertrichosis (HP:0004540)1.82184563
142Abnormal mitochondria in muscle tissue (HP:0008316)1.82038113
143Glioma (HP:0009733)1.80175940
144Short humerus (HP:0005792)1.79004991
145Horizontal nystagmus (HP:0000666)1.78968874
146Clumsiness (HP:0002312)1.77935401
147Premature graying of hair (HP:0002216)1.77577224
148Oligodactyly (hands) (HP:0001180)1.77396933
149Dysmetric saccades (HP:0000641)1.76531442
150Osteolytic defects of the phalanges of the hand (HP:0009771)1.76250281
151Osteolytic defects of the hand bones (HP:0009699)1.76250281
152Muscle stiffness (HP:0003552)1.75212172
153Lactic acidosis (HP:0003128)1.74914431
154Segmental peripheral demyelination/remyelination (HP:0003481)1.74701825
155Abnormality of the shoulder girdle musculature (HP:0001435)1.74165808
156Cellular immunodeficiency (HP:0005374)1.73114400
157Renal cortical cysts (HP:0000803)1.72420411
158Abnormality of the calcaneus (HP:0008364)1.72409687
159Homocystinuria (HP:0002156)1.71495872
160Abnormality of homocysteine metabolism (HP:0010919)1.71495872
161Dilated cardiomyopathy (HP:0001644)1.71385026
162Abnormal biliary tract physiology (HP:0012439)1.70905345
163Bile duct proliferation (HP:0001408)1.70905345
164Neck muscle weakness (HP:0000467)1.70374716
165Acute necrotizing encephalopathy (HP:0006965)1.70214021
166Unsteady gait (HP:0002317)1.69263933
167Hyporeflexia of lower limbs (HP:0002600)1.68174797
168Aplasia/Hypoplasia of the sternum (HP:0006714)1.67397418
169Increased muscle lipid content (HP:0009058)1.67134249
170Broad-based gait (HP:0002136)1.64582252
171Abnormality of the renal collecting system (HP:0004742)1.62563558
172Acute encephalopathy (HP:0006846)1.61190278
173Prominent metopic ridge (HP:0005487)1.61073145

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.42512069
2OBSCN4.23206336
3WEE14.15042487
4EPHA23.21368308
5AKT33.14124037
6NEK22.99088617
7PLK42.82111867
8TSSK62.69618404
9EIF2AK12.58625986
10PHKG22.51067757
11PHKG12.51067757
12NME22.46464825
13CDK192.35781049
14PDK32.34813643
15PDK42.34813643
16TTK2.27757073
17IRAK32.04201075
18ZAK2.01168437
19PBK1.97579335
20SRPK11.90218225
21PDK21.90077429
22TTN1.89032679
23BRSK21.87831474
24PLK11.86142429
25STK161.80071357
26BMPR1B1.74639305
27DYRK31.69429176
28NEK11.69412003
29EEF2K1.62079791
30MKNK21.56258094
31EIF2AK31.54920144
32CDC71.48858054
33PNCK1.47821465
34PLK31.46269000
35CAMK1G1.40294057
36STK31.34505385
37CHEK21.33733563
38RPS6KA41.31034107
39ACVR1B1.30612483
40TESK21.30280633
41CDK41.27901614
42MAP3K31.27774730
43NUAK11.26480904
44AURKB1.26353650
45CDK121.26148492
46PIM11.16225314
47PIM21.14053599
48ATR1.11521058
49MKNK11.09389168
50CDK71.08060715
51MAP4K21.03694552
52BRSK11.02957666
53MAP3K81.02888248
54MET1.02870466
55CLK11.01811018
56CHEK10.99643534
57STK38L0.97486436
58STK100.94236248
59AURKA0.92484612
60PINK10.88891969
61ALK0.86967587
62MAP3K70.85639690
63RPS6KB20.85630956
64CCNB10.82004502
65VRK20.80333933
66CAMK1D0.80175503
67STK40.78772847
68ZAP700.77003749
69BRAF0.76008021
70FRK0.75921771
71ARAF0.75435345
72EIF2AK20.74660541
73IKBKB0.72099712
74TAOK20.71004367
75MAP2K20.69633249
76CDK20.69558260
77BCKDK0.67193962
78PASK0.66756910
79BMX0.66515954
80MAP2K30.64903862
81MST40.64191822
82PRKCI0.64057905
83MTOR0.64002743
84PAK40.63856110
85RPS6KA50.62432015
86WNK40.62173375
87MAP4K10.61243414
88MARK30.59978485
89TXK0.59912675
90ERBB40.59828574
91TYK20.59457771
92CAMK40.58458781
93PAK10.58273527
94LATS10.57848573
95TGFBR10.57778264
96ATM0.55835173
97MELK0.54577520
98PRKDC0.54179486
99LATS20.52316419
100TAF10.51023551
101ADRBK20.50706525
102CHUK0.50309303
103CDK80.50075536
104MAPKAPK30.49294203
105OXSR10.47656046
106CSNK2A20.46675465
107MAP2K60.46030217
108CSNK2A10.44842384
109CDK10.42807557
110VRK10.40065777
111MAPK110.39497388
112STK240.38970521
113MAP3K100.38908823
114CDK60.38464514
115MAP3K50.37106605
116TLK10.36877251
117CSNK1A1L0.36871919
118STK380.36647857
119CSNK1E0.36303046
120PRKAA20.35035870
121BRD40.34986516
122CAMK10.34392386
123RPS6KB10.34081397
124FGFR40.33959911
125DYRK20.33557613
126PRKAA10.32837809
127GSK3B0.32665899
128MAPK140.31288792
129NME10.31017155
130CSNK1G30.30884790
131CDK30.25508800
132RAF10.21560710
133PAK20.19518354
134NLK0.18516309
135AKT20.17687267
136MAP3K110.17674804
137RPS6KA10.17249204
138CSNK1G10.17065666

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.16410597
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.23888007
3RNA polymerase_Homo sapiens_hsa030203.73977085
4RNA transport_Homo sapiens_hsa030133.24276387
5DNA replication_Homo sapiens_hsa030303.00970704
6Proteasome_Homo sapiens_hsa030502.98585371
7Mismatch repair_Homo sapiens_hsa034302.47599295
8Spliceosome_Homo sapiens_hsa030402.38872668
9Folate biosynthesis_Homo sapiens_hsa007902.32852454
10Pyrimidine metabolism_Homo sapiens_hsa002402.30686185
11Cell cycle_Homo sapiens_hsa041102.29832999
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.26639437
13Regulation of autophagy_Homo sapiens_hsa041402.11288144
14Base excision repair_Homo sapiens_hsa034102.04086701
15Nucleotide excision repair_Homo sapiens_hsa034202.01638236
16Basal transcription factors_Homo sapiens_hsa030222.00375206
17Homologous recombination_Homo sapiens_hsa034401.95904839
18Fanconi anemia pathway_Homo sapiens_hsa034601.85746264
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83741638
20One carbon pool by folate_Homo sapiens_hsa006701.83454467
21p53 signaling pathway_Homo sapiens_hsa041151.80301819
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.71343268
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.70940109
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.69245565
25Pyruvate metabolism_Homo sapiens_hsa006201.64371959
26Lysine degradation_Homo sapiens_hsa003101.57177511
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53128218
28Pentose phosphate pathway_Homo sapiens_hsa000301.52508143
29Propanoate metabolism_Homo sapiens_hsa006401.52224266
30Ribosome_Homo sapiens_hsa030101.43523319
31Purine metabolism_Homo sapiens_hsa002301.41481736
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.40595977
33Parkinsons disease_Homo sapiens_hsa050121.38823470
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38753623
35mRNA surveillance pathway_Homo sapiens_hsa030151.36683161
36Epstein-Barr virus infection_Homo sapiens_hsa051691.33951370
37Selenocompound metabolism_Homo sapiens_hsa004501.25568071
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.23705822
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.21903754
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20594588
41Vitamin digestion and absorption_Homo sapiens_hsa049771.14582329
42Cardiac muscle contraction_Homo sapiens_hsa042601.14431504
43RNA degradation_Homo sapiens_hsa030181.13692038
44Antigen processing and presentation_Homo sapiens_hsa046121.03890236
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03368914
46Biosynthesis of amino acids_Homo sapiens_hsa012301.01968292
47Huntingtons disease_Homo sapiens_hsa050161.01815263
48Oxidative phosphorylation_Homo sapiens_hsa001901.01762230
49Fructose and mannose metabolism_Homo sapiens_hsa000511.01136105
50Non-homologous end-joining_Homo sapiens_hsa034501.00018437
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98369601
52Fatty acid elongation_Homo sapiens_hsa000620.97409469
53Herpes simplex infection_Homo sapiens_hsa051680.83943412
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83199958
55Sulfur relay system_Homo sapiens_hsa041220.81158545
56Oocyte meiosis_Homo sapiens_hsa041140.78956272
57Butanoate metabolism_Homo sapiens_hsa006500.77858927
58Legionellosis_Homo sapiens_hsa051340.76925437
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.74195772
60Viral carcinogenesis_Homo sapiens_hsa052030.73641084
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71017891
62Glucagon signaling pathway_Homo sapiens_hsa049220.70162722
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64977899
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63361937
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62488946
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62433920
67Carbon metabolism_Homo sapiens_hsa012000.58850922
68Fatty acid metabolism_Homo sapiens_hsa012120.58510094
69Arginine biosynthesis_Homo sapiens_hsa002200.58279627
70Alzheimers disease_Homo sapiens_hsa050100.57716203
71Protein export_Homo sapiens_hsa030600.56031401
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54665803
73Glutathione metabolism_Homo sapiens_hsa004800.54254112
74mTOR signaling pathway_Homo sapiens_hsa041500.53943860
75Insulin signaling pathway_Homo sapiens_hsa049100.49549226
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.49373464
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49333495
78Dilated cardiomyopathy_Homo sapiens_hsa054140.49275202
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48914817
80Tryptophan metabolism_Homo sapiens_hsa003800.48142461
81Apoptosis_Homo sapiens_hsa042100.46931593
82Measles_Homo sapiens_hsa051620.46494122
83HTLV-I infection_Homo sapiens_hsa051660.46385629
84Systemic lupus erythematosus_Homo sapiens_hsa053220.46183564
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.44612108
86Small cell lung cancer_Homo sapiens_hsa052220.44022075
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43960443
88Peroxisome_Homo sapiens_hsa041460.42837227
89Primary immunodeficiency_Homo sapiens_hsa053400.41723513
90Arginine and proline metabolism_Homo sapiens_hsa003300.40446311
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39580183
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38952731
93Circadian rhythm_Homo sapiens_hsa047100.38938599
94Galactose metabolism_Homo sapiens_hsa000520.38696182
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37708747
96Fatty acid degradation_Homo sapiens_hsa000710.35728857
97Glycerolipid metabolism_Homo sapiens_hsa005610.35479011
98Lysosome_Homo sapiens_hsa041420.35087322
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34711121
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34635697
101FoxO signaling pathway_Homo sapiens_hsa040680.33814798
102N-Glycan biosynthesis_Homo sapiens_hsa005100.33810560
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31387035
104Metabolic pathways_Homo sapiens_hsa011000.30814711
105Influenza A_Homo sapiens_hsa051640.30616028
106Allograft rejection_Homo sapiens_hsa053300.30100078
107MicroRNAs in cancer_Homo sapiens_hsa052060.29771303
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29571577
109Renin-angiotensin system_Homo sapiens_hsa046140.29524234
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29066413
111beta-Alanine metabolism_Homo sapiens_hsa004100.27927014
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27605069
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.26740168
114HIF-1 signaling pathway_Homo sapiens_hsa040660.25382759
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.25210266
116Inositol phosphate metabolism_Homo sapiens_hsa005620.24317642
117Graft-versus-host disease_Homo sapiens_hsa053320.22931619
118Linoleic acid metabolism_Homo sapiens_hsa005910.22677032
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.22628038
120Insulin resistance_Homo sapiens_hsa049310.22396374
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22197852
122Hedgehog signaling pathway_Homo sapiens_hsa043400.21266384
123Retinol metabolism_Homo sapiens_hsa008300.20114797
124Arachidonic acid metabolism_Homo sapiens_hsa005900.19564492
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.19512617
126Hippo signaling pathway_Homo sapiens_hsa043900.19357722
127Oxytocin signaling pathway_Homo sapiens_hsa049210.19277138
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18796310
129Acute myeloid leukemia_Homo sapiens_hsa052210.17941363
130Asthma_Homo sapiens_hsa053100.17231699
131Calcium signaling pathway_Homo sapiens_hsa040200.16256758
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.15692632
133Hepatitis B_Homo sapiens_hsa051610.15579898
134Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.14107457
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14067172
136AMPK signaling pathway_Homo sapiens_hsa041520.12537366
137Prostate cancer_Homo sapiens_hsa052150.11697895
138Phototransduction_Homo sapiens_hsa047440.11233276
139Maturity onset diabetes of the young_Homo sapiens_hsa049500.10886059
140Hematopoietic cell lineage_Homo sapiens_hsa046400.10845141
141Nitrogen metabolism_Homo sapiens_hsa009100.10476111
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.09902796
143T cell receptor signaling pathway_Homo sapiens_hsa046600.09704976

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