ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.60349842
2	NADH dehydrogenase complex assembly (GO:0010257)	4.60349842
3	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.60349842
4	protein complex biogenesis (GO:0070271)	4.52892688
5	fucose catabolic process (GO:0019317)	4.39733783
6	L-fucose metabolic process (GO:0042354)	4.39733783
7	L-fucose catabolic process (GO:0042355)	4.39733783
8	water-soluble vitamin biosynthetic process (GO:0042364)	4.34506834
9	negative regulation of mast cell activation (GO:0033004)	4.03648740
10	mitochondrial respiratory chain complex assembly (GO:0033108)	4.03193735
11	gamma-aminobutyric acid transport (GO:0015812)	3.97086087
12	detection of light stimulus involved in sensory perception (GO:0050962)	3.82151454
13	detection of light stimulus involved in visual perception (GO:0050908)	3.82151454
14	behavioral response to nicotine (GO:0035095)	3.80535414
15	respiratory chain complex IV assembly (GO:0008535)	3.79784265
16	DNA deamination (GO:0045006)	3.75663627
17	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.60967323
18	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.60967323
19	piRNA metabolic process (GO:0034587)	3.58618372
20	platelet dense granule organization (GO:0060155)	3.56426435
21	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.55493560
22	ATP synthesis coupled proton transport (GO:0015986)	3.55493560
23	protein polyglutamylation (GO:0018095)	3.44781170
24	cytochrome complex assembly (GO:0017004)	3.42602877
25	preassembly of GPI anchor in ER membrane (GO:0016254)	3.37571520
26	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.34952983
27	regulation of action potential (GO:0098900)	3.31059563
28	response to pheromone (GO:0019236)	3.27702028
29	protein-cofactor linkage (GO:0018065)	3.25958239
30	tryptophan catabolic process (GO:0006569)	3.15853922
31	indole-containing compound catabolic process (GO:0042436)	3.15853922
32	indolalkylamine catabolic process (GO:0046218)	3.15853922
33	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.12260268
34	neuronal action potential (GO:0019228)	3.11699512
35	RNA destabilization (GO:0050779)	3.08945653
36	negative regulation of telomere maintenance (GO:0032205)	3.08672896
37	indolalkylamine metabolic process (GO:0006586)	3.07089893
38	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.06891560
39	cellular ketone body metabolic process (GO:0046950)	3.06830375
40	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.02656107
41	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.00262435
42	protein localization to cilium (GO:0061512)	2.99347024
43	sulfation (GO:0051923)	2.98870562
44	DNA methylation involved in gamete generation (GO:0043046)	2.98504900
45	regulation of cilium movement (GO:0003352)	2.97768492
46	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.94659270
47	glycerophospholipid catabolic process (GO:0046475)	2.92682764
48	rRNA catabolic process (GO:0016075)	2.90951585
49	chaperone-mediated protein transport (GO:0072321)	2.90193729
50	base-excision repair, AP site formation (GO:0006285)	2.88239849
51	pyrimidine nucleobase catabolic process (GO:0006208)	2.87052054
52	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.86635915
53	retinal cone cell development (GO:0046549)	2.84147891
54	neurofilament cytoskeleton organization (GO:0060052)	2.82944303
55	epithelial cilium movement (GO:0003351)	2.82360105
56	ketone body metabolic process (GO:1902224)	2.78801106
57	axoneme assembly (GO:0035082)	2.77655832
58	somite rostral/caudal axis specification (GO:0032525)	2.75642588
59	GPI anchor metabolic process (GO:0006505)	2.74784136
60	nucleobase catabolic process (GO:0046113)	2.73063607
61	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.72970315
62	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.72406485
63	cilium morphogenesis (GO:0060271)	2.70311338
64	kynurenine metabolic process (GO:0070189)	2.70118178
65	kidney morphogenesis (GO:0060993)	2.69549010
66	neuron fate determination (GO:0048664)	2.68134329
67	electron transport chain (GO:0022900)	2.67695673
68	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.67560698
69	protein K11-linked deubiquitination (GO:0035871)	2.64833044
70	photoreceptor cell development (GO:0042461)	2.64177530
71	multicellular organism reproduction (GO:0032504)	2.63764343
72	tryptophan metabolic process (GO:0006568)	2.63725419
73	regulation of hexokinase activity (GO:1903299)	2.61671694
74	regulation of glucokinase activity (GO:0033131)	2.61671694
75	respiratory electron transport chain (GO:0022904)	2.59813601
76	short-chain fatty acid metabolic process (GO:0046459)	2.59668031
77	tRNA processing (GO:0008033)	2.57207824
78	reflex (GO:0060004)	2.56519365
79	startle response (GO:0001964)	2.56470127
80	regulation of timing of cell differentiation (GO:0048505)	2.54298219
81	regulation of feeding behavior (GO:0060259)	2.52990947
82	positive regulation of action potential (GO:0045760)	2.51574678
83	calcium ion import (GO:0070509)	2.51194616
84	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.50101723
85	cellular biogenic amine catabolic process (GO:0042402)	2.50090518
86	amine catabolic process (GO:0009310)	2.50090518
87	activated T cell proliferation (GO:0050798)	2.48310831
88	proline transport (GO:0015824)	2.48024458
89	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.47959113
90	L-methionine salvage (GO:0071267)	2.47678537
91	L-methionine biosynthetic process (GO:0071265)	2.47678537
92	amino acid salvage (GO:0043102)	2.47678537
93	dopamine transport (GO:0015872)	2.46783948
94	iron-sulfur cluster assembly (GO:0016226)	2.46705413
95	metallo-sulfur cluster assembly (GO:0031163)	2.46705413
96	interferon-gamma production (GO:0032609)	2.46145719
97	protein neddylation (GO:0045116)	2.45078524
98	mannosylation (GO:0097502)	2.42082839
99	rhodopsin mediated signaling pathway (GO:0016056)	2.38908283
100	membrane depolarization during action potential (GO:0086010)	2.37320374

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.66088577
2	GBX2_23144817_ChIP-Seq_PC3_Human	2.93887119
3	VDR_22108803_ChIP-Seq_LS180_Human	2.93270347
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.71807985
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.66207631
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.55882026
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.48346344
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.39811222
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.39609959
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.36218610
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.26497374
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.24739828
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.22142000
14	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.13353336
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.12667188
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.11103364
17	EWS_26573619_Chip-Seq_HEK293_Human	2.10535569
18	FUS_26573619_Chip-Seq_HEK293_Human	2.09823717
19	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.03900563
20	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.01307844
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.01071148
22	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.92606966
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.92528061
24	P300_19829295_ChIP-Seq_ESCs_Human	1.86419442
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.83416837
26	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.82772044
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.80543354
28	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.77824284
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.77564128
30	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.60979969
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.56123123
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.55464169
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.55464169
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.55433023
35	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.54131320
36	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.54044115
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.53074758
38	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.52272189
39	REST_21632747_ChIP-Seq_MESCs_Mouse	1.51798879
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.51471384
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.51303386
42	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.49943362
43	VDR_23849224_ChIP-Seq_CD4+_Human	1.46504628
44	RNF2_27304074_Chip-Seq_NSC_Mouse	1.46376837
45	AR_25329375_ChIP-Seq_VCAP_Human	1.41851197
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.41066946
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.41066946
48	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.39850663
49	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.39775054
50	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.39364171
51	BCAT_22108803_ChIP-Seq_LS180_Human	1.35165345
52	ELK1_19687146_ChIP-ChIP_HELA_Human	1.33077608
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.30274240
54	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.30182127
55	SMAD4_21799915_ChIP-Seq_A2780_Human	1.30016858
56	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.29162359
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26938377
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26938377
59	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.26682968
60	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.23951938
61	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.23836349
62	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.23481252
63	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.23464381
64	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.22832283
65	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.22454272
66	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.20818420
67	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.20606298
68	STAT3_23295773_ChIP-Seq_U87_Human	1.20027815
69	TCF4_23295773_ChIP-Seq_U87_Human	1.18520861
70	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.18436991
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.17714155
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17275365
73	TCF4_22108803_ChIP-Seq_LS180_Human	1.14125295
74	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.13611535
75	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.13518038
76	AR_20517297_ChIP-Seq_VCAP_Human	1.13184414
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.11172432
78	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10349271
79	NCOR_22424771_ChIP-Seq_293T_Human	1.10332123
80	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.10296914
81	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.07950717
82	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.07909247
83	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07600120
84	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.06920949
85	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.06276770
86	RUNX2_22187159_ChIP-Seq_PCA_Human	1.05505942
87	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.04971727
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.03117132
89	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.00942966
90	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.00316588
91	HOXB7_26014856_ChIP-Seq_BT474_Human	0.98499808
92	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98025230
93	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.98025230
94	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.96706483
95	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.96102565
96	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.95792400
97	FOXP3_21729870_ChIP-Seq_TREG_Human	0.95102942
98	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.94419551
99	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.93182659
100	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.92802273

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.69505392
2	MP0000569_abnormal_digit_pigmentation	2.98375318
3	MP0006072_abnormal_retinal_apoptosis	2.90196693
4	MP0003880_abnormal_central_pattern	2.72098536
5	MP0002638_abnormal_pupillary_reflex	2.59456445
6	MP0002837_dystrophic_cardiac_calcinosis	2.46680395
7	MP0005645_abnormal_hypothalamus_physiol	2.42318421
8	MP0005551_abnormal_eye_electrophysiolog	2.41644552
9	MP0002102_abnormal_ear_morphology	2.37445666
10	MP0005253_abnormal_eye_physiology	2.02523084
11	MP0003195_calcinosis	2.01399905
12	MP0003787_abnormal_imprinting	1.98678389
13	MP0001485_abnormal_pinna_reflex	1.93879571
14	MP0005646_abnormal_pituitary_gland	1.89500954
15	MP0009745_abnormal_behavioral_response	1.88479442
16	MP0004142_abnormal_muscle_tone	1.86962454
17	MP0002272_abnormal_nervous_system	1.82069879
18	MP0001968_abnormal_touch/_nociception	1.81251699
19	MP0009046_muscle_twitch	1.79880025
20	MP0002822_catalepsy	1.79323981
21	MP0008995_early_reproductive_senescence	1.79290243
22	MP0001984_abnormal_olfaction	1.76365690
23	MP0005174_abnormal_tail_pigmentation	1.75200625
24	MP0003646_muscle_fatigue	1.74205728
25	MP0001529_abnormal_vocalization	1.70816661
26	MP0005423_abnormal_somatic_nervous	1.70727512
27	MP0001986_abnormal_taste_sensitivity	1.69479531
28	MP0004133_heterotaxia	1.67227238
29	MP0008872_abnormal_physiological_respon	1.67074732
30	MP0002876_abnormal_thyroid_physiology	1.63381216
31	MP0000372_irregular_coat_pigmentation	1.61460835
32	MP0002938_white_spotting	1.58838464
33	MP0005084_abnormal_gallbladder_morpholo	1.56353367
34	MP0004742_abnormal_vestibular_system	1.54397087
35	MP0002736_abnormal_nociception_after	1.53682846
36	MP0006276_abnormal_autonomic_nervous	1.51215683
37	MP0008875_abnormal_xenobiotic_pharmacok	1.49915212
38	MP0001486_abnormal_startle_reflex	1.42419461
39	MP0001501_abnormal_sleep_pattern	1.38607504
40	MP0000566_synostosis	1.37312615
41	MP0002163_abnormal_gland_morphology	1.32186065
42	MP0002557_abnormal_social/conspecific_i	1.31964757
43	MP0003011_delayed_dark_adaptation	1.31025317
44	MP0002572_abnormal_emotion/affect_behav	1.30005391
45	MP0001970_abnormal_pain_threshold	1.28912016
46	MP0005075_abnormal_melanosome_morpholog	1.27618110
47	MP0005389_reproductive_system_phenotype	1.27525706
48	MP0002064_seizures	1.26971567
49	MP0002733_abnormal_thermal_nociception	1.23501992
50	MP0001919_abnormal_reproductive_system	1.22931742
51	MP0004885_abnormal_endolymph	1.21395156
52	MP0004924_abnormal_behavior	1.20459666
53	MP0005386_behavior/neurological_phenoty	1.20459666
54	MP0005671_abnormal_response_to	1.19761549
55	MP0005379_endocrine/exocrine_gland_phen	1.18982758
56	MP0002735_abnormal_chemical_nociception	1.16446221
57	MP0004043_abnormal_pH_regulation	1.15069047
58	MP0006292_abnormal_olfactory_placode	1.11534237
59	MP0001905_abnormal_dopamine_level	1.11521698
60	MP0000631_abnormal_neuroendocrine_gland	1.10685263
61	MP0004147_increased_porphyrin_level	1.07684167
62	MP0001764_abnormal_homeostasis	1.04577518
63	MP0005410_abnormal_fertilization	1.03803514
64	MP0003635_abnormal_synaptic_transmissio	1.03362731
65	MP0002653_abnormal_ependyma_morphology	1.02836334
66	MP0003878_abnormal_ear_physiology	1.02022883
67	MP0005377_hearing/vestibular/ear_phenot	1.02022883
68	MP0000015_abnormal_ear_pigmentation	1.01439560
69	MP0002067_abnormal_sensory_capabilities	0.98318173
70	MP0003136_yellow_coat_color	0.96936929
71	MP0005195_abnormal_posterior_eye	0.96438188
72	MP0002160_abnormal_reproductive_system	0.96236572
73	MP0002138_abnormal_hepatobiliary_system	0.90177172
74	MP0001502_abnormal_circadian_rhythm	0.89375866
75	MP0002095_abnormal_skin_pigmentation	0.88982616
76	MP0003806_abnormal_nucleotide_metabolis	0.87194830
77	MP0002693_abnormal_pancreas_physiology	0.85883840
78	MP0002063_abnormal_learning/memory/cond	0.85512270
79	MP0002734_abnormal_mechanical_nocicepti	0.84682266
80	MP0002210_abnormal_sex_determination	0.82785344
81	MP0001929_abnormal_gametogenesis	0.82398306
82	MP0002928_abnormal_bile_duct	0.81644174
83	MP0003121_genomic_imprinting	0.81247590
84	MP0002752_abnormal_somatic_nervous	0.80937675
85	MP0000026_abnormal_inner_ear	0.80692023
86	MP0001963_abnormal_hearing_physiology	0.80678048
87	MP0008789_abnormal_olfactory_epithelium	0.80279968
88	MP0003698_abnormal_male_reproductive	0.79982263
89	MP0002229_neurodegeneration	0.78793876
90	MP0001324_abnormal_eye_pigmentation	0.77253789
91	MP0003718_maternal_effect	0.76791001
92	MP0008775_abnormal_heart_ventricle	0.76643354
93	MP0005332_abnormal_amino_acid	0.76410516
94	MP0008058_abnormal_DNA_repair	0.76195325
95	MP0003122_maternal_imprinting	0.74015704
96	MP0003567_abnormal_fetal_cardiomyocyte	0.73957013
97	MP0002277_abnormal_respiratory_mucosa	0.73774341
98	MP0003890_abnormal_embryonic-extraembry	0.73584625
99	MP0004215_abnormal_myocardial_fiber	0.72754569
100	MP0001944_abnormal_pancreas_morphology	0.71767227

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.17680240
2	Pancreatic cysts (HP:0001737)	3.81492879
3	Acute necrotizing encephalopathy (HP:0006965)	3.74097825
4	Molar tooth sign on MRI (HP:0002419)	3.67205519
5	Abnormality of midbrain morphology (HP:0002418)	3.67205519
6	Hypothermia (HP:0002045)	3.53273772
7	Pancreatic fibrosis (HP:0100732)	3.51790438
8	Acute encephalopathy (HP:0006846)	3.48716188
9	True hermaphroditism (HP:0010459)	3.36453793
10	Progressive macrocephaly (HP:0004481)	3.29949899
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.25359791
12	3-Methylglutaconic aciduria (HP:0003535)	3.20257411
13	Mitochondrial inheritance (HP:0001427)	3.19554325
14	Increased CSF lactate (HP:0002490)	3.10964587
15	Nephronophthisis (HP:0000090)	3.07095871
16	Abnormality of the renal cortex (HP:0011035)	2.96496558
17	Type II lissencephaly (HP:0007260)	2.90447377
18	Methylmalonic acidemia (HP:0002912)	2.89153577
19	Hyperglycinemia (HP:0002154)	2.88338643
20	Medial flaring of the eyebrow (HP:0010747)	2.82785892
21	Polydipsia (HP:0001959)	2.80278745
22	Abnormal drinking behavior (HP:0030082)	2.80278745
23	Abolished electroretinogram (ERG) (HP:0000550)	2.78111442
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.72835457
25	Tubular atrophy (HP:0000092)	2.55957429
26	Renal cortical cysts (HP:0000803)	2.54983041
27	Abnormality of the renal medulla (HP:0100957)	2.54333027
28	Hepatocellular necrosis (HP:0001404)	2.51174032
29	Lipid accumulation in hepatocytes (HP:0006561)	2.47846390
30	Methylmalonic aciduria (HP:0012120)	2.47505134
31	Increased hepatocellular lipid droplets (HP:0006565)	2.46441904
32	Abnormality of the pons (HP:0007361)	2.45286886
33	Hepatic necrosis (HP:0002605)	2.42713081
34	Large for gestational age (HP:0001520)	2.42703847
35	Optic nerve hypoplasia (HP:0000609)	2.40624354
36	Hypoplasia of the pons (HP:0012110)	2.37486885
37	Congenital, generalized hypertrichosis (HP:0004540)	2.36431094
38	Inability to walk (HP:0002540)	2.34511748
39	Optic disc pallor (HP:0000543)	2.32590298
40	Attenuation of retinal blood vessels (HP:0007843)	2.30308626
41	Chronic hepatic failure (HP:0100626)	2.28428115
42	Severe muscular hypotonia (HP:0006829)	2.25958869
43	Gaze-evoked nystagmus (HP:0000640)	2.25576905
44	Febrile seizures (HP:0002373)	2.21873906
45	Hemiparesis (HP:0001269)	2.21530762
46	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.20008138
47	Ketoacidosis (HP:0001993)	2.18925014
48	Cystic liver disease (HP:0006706)	2.18509418
49	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.18103466
50	Abnormal biliary tract physiology (HP:0012439)	2.12663255
51	Bile duct proliferation (HP:0001408)	2.12663255
52	Polyuria (HP:0000103)	2.10848465
53	Cerebral edema (HP:0002181)	2.10609945
54	Increased serum lactate (HP:0002151)	2.08491353
55	Progressive inability to walk (HP:0002505)	2.08432121
56	Lissencephaly (HP:0001339)	2.05703056
57	Abnormality of serine family amino acid metabolism (HP:0010894)	2.05528176
58	Abnormality of glycine metabolism (HP:0010895)	2.05528176
59	Tubulointerstitial nephritis (HP:0001970)	2.05474847
60	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.05269296
61	Gait imbalance (HP:0002141)	2.02685480
62	Chorioretinal atrophy (HP:0000533)	2.02593441
63	Stomatitis (HP:0010280)	2.01646875
64	Cerebellar dysplasia (HP:0007033)	2.01349697
65	Abnormality of alanine metabolism (HP:0010916)	2.00622764
66	Hyperalaninemia (HP:0003348)	2.00622764
67	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.00622764
68	Ketosis (HP:0001946)	1.98651907
69	Abnormality of vitamin B metabolism (HP:0004340)	1.98616347
70	Congenital primary aphakia (HP:0007707)	1.97934501
71	Decreased central vision (HP:0007663)	1.96452213
72	Lactic acidosis (HP:0003128)	1.94478183
73	Aplasia/hypoplasia of the uterus (HP:0008684)	1.94303885
74	Intestinal atresia (HP:0011100)	1.93925494
75	Sclerocornea (HP:0000647)	1.93762292
76	Hyperglycinuria (HP:0003108)	1.92314765
77	Hypomagnesemia (HP:0002917)	1.90518018
78	Short tibia (HP:0005736)	1.89597780
79	Congenital hepatic fibrosis (HP:0002612)	1.89477217
80	Renal Fanconi syndrome (HP:0001994)	1.88676159
81	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.88517511
82	Progressive microcephaly (HP:0000253)	1.87205316
83	Lethargy (HP:0001254)	1.85754634
84	Dyskinesia (HP:0100660)	1.84474690
85	Nephrogenic diabetes insipidus (HP:0009806)	1.84341683
86	Limb dystonia (HP:0002451)	1.82631844
87	Abnormality of the labia minora (HP:0012880)	1.81904339
88	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.79684406
89	Hypoplasia of the fovea (HP:0007750)	1.79684406
90	Congenital sensorineural hearing impairment (HP:0008527)	1.79658865
91	Decreased circulating renin level (HP:0003351)	1.78580793
92	Hyperventilation (HP:0002883)	1.78463311
93	Genital tract atresia (HP:0001827)	1.76234503
94	Male pseudohermaphroditism (HP:0000037)	1.75530510
95	Anencephaly (HP:0002323)	1.74825684
96	Respiratory failure (HP:0002878)	1.74589199
97	Pachygyria (HP:0001302)	1.74121224
98	Abnormal number of erythroid precursors (HP:0012131)	1.73597914
99	Broad-based gait (HP:0002136)	1.73509019
100	Glycosuria (HP:0003076)	1.73256746

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.46257269
2	MAP4K2	3.59986399
3	PINK1	3.44672089
4	ADRBK2	3.00122653
5	TAOK3	2.66486045
6	ZAK	2.65340907
7	TLK1	2.55713348
8	GRK1	2.55200997
9	BMPR1B	2.38252672
10	WNK3	2.37986781
11	CASK	2.28285361
12	TXK	2.13235852
13	SIK2	2.03255293
14	WNK4	1.82113818
15	NUAK1	1.80670609
16	MST4	1.65022124
17	MAPK13	1.57762571
18	STK16	1.52081448
19	INSRR	1.42172908
20	PAK3	1.41936001
21	OXSR1	1.39892262
22	TRIM28	1.34737119
23	MAPKAPK3	1.24709738
24	VRK1	1.23772709
25	TNK2	1.23351813
26	MKNK2	1.22822572
27	CAMKK2	1.20942318
28	DYRK2	1.20056128
29	STK39	1.19350086
30	TIE1	1.17175831
31	PRKCG	1.10509865
32	MAP3K4	1.10304044
33	VRK2	1.05180101
34	ACVR1B	1.04913552
35	MAPK15	1.04072146
36	BCKDK	1.01250706
37	IRAK1	0.98824065
38	MARK1	0.98230445
39	PRKCE	0.94028269
40	MAP2K7	0.93093236
41	CSNK1G1	0.91354748
42	ADRBK1	0.90653799
43	TNIK	0.85841654
44	IKBKB	0.83899037
45	TGFBR1	0.83608321
46	PHKG1	0.83308994
47	PHKG2	0.83308994
48	ERBB3	0.82789617
49	SRPK1	0.76312897
50	CSNK1G2	0.73185591
51	DAPK2	0.72430297
52	CSNK1G3	0.72067829
53	TSSK6	0.70839137
54	BRSK2	0.69172914
55	KIT	0.68928367
56	TEC	0.67619732
57	MKNK1	0.66546778
58	RPS6KA5	0.66225458
59	PNCK	0.65925761
60	MAP2K6	0.65399450
61	LIMK1	0.64734820
62	PRKCQ	0.63355824
63	CDK8	0.62158217
64	MAP4K1	0.58585772
65	MUSK	0.57901176
66	PLK3	0.54927981
67	IKBKE	0.53766758
68	FER	0.53388808
69	PTK2B	0.53337447
70	NME1	0.52265210
71	WNK1	0.51687046
72	CSNK1A1	0.51057022
73	NTRK2	0.50805411
74	PRKACA	0.49891395
75	GRK7	0.49342192
76	EPHA3	0.48974440
77	PLK2	0.48930013
78	MINK1	0.48080496
79	CHUK	0.47298685
80	PASK	0.46363661
81	CAMK2A	0.46162931
82	CSNK1A1L	0.45857626
83	EIF2AK3	0.44073074
84	ITK	0.40269687
85	STK38L	0.39671848
86	PRKCA	0.39456288
87	PKN1	0.37698995
88	DYRK1A	0.37180503
89	ABL1	0.36360105
90	PRKG1	0.36065579
91	PRKCZ	0.35623873
92	NLK	0.35083420
93	PDK2	0.34940536
94	CAMK1	0.34795040
95	GRK6	0.33607255
96	PIM2	0.33169308
97	SYK	0.32961605
98	FGFR2	0.32735595
99	CSNK1D	0.32459085
100	CAMK2D	0.29763006

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.08334674
2	Phototransduction_Homo sapiens_hsa04744	2.95181425
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.63680488
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.46266670
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.43788738
6	Parkinsons disease_Homo sapiens_hsa05012	2.43263489
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.38212561
8	Protein export_Homo sapiens_hsa03060	2.28948929
9	Butanoate metabolism_Homo sapiens_hsa00650	2.21690050
10	Nicotine addiction_Homo sapiens_hsa05033	2.17003248
11	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.09920793
12	Linoleic acid metabolism_Homo sapiens_hsa00591	2.05959001
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.04641868
14	RNA polymerase_Homo sapiens_hsa03020	1.88387045
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.78391147
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.77592912
17	RNA degradation_Homo sapiens_hsa03018	1.76935426
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.70621154
19	Basal transcription factors_Homo sapiens_hsa03022	1.65021778
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.64523914
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.57418227
22	Ribosome_Homo sapiens_hsa03010	1.56126059
23	Regulation of autophagy_Homo sapiens_hsa04140	1.56003368
24	Alzheimers disease_Homo sapiens_hsa05010	1.55467043
25	Propanoate metabolism_Homo sapiens_hsa00640	1.54382528
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.53145188
27	Huntingtons disease_Homo sapiens_hsa05016	1.50337718
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.47661592
29	Taste transduction_Homo sapiens_hsa04742	1.46625318
30	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.46359346
31	Homologous recombination_Homo sapiens_hsa03440	1.43987738
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.42479324
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.37759502
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.35627483
35	Proteasome_Homo sapiens_hsa03050	1.32610094
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.25975161
37	Peroxisome_Homo sapiens_hsa04146	1.22028844
38	Fanconi anemia pathway_Homo sapiens_hsa03460	1.20797416
39	Olfactory transduction_Homo sapiens_hsa04740	1.14363958
40	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.13769834
41	Sulfur metabolism_Homo sapiens_hsa00920	1.13500076
42	One carbon pool by folate_Homo sapiens_hsa00670	1.12563211
43	GABAergic synapse_Homo sapiens_hsa04727	1.07521430
44	Type I diabetes mellitus_Homo sapiens_hsa04940	1.03296039
45	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.00855005
46	Chemical carcinogenesis_Homo sapiens_hsa05204	0.97460155
47	Caffeine metabolism_Homo sapiens_hsa00232	0.95158833
48	Morphine addiction_Homo sapiens_hsa05032	0.94839244
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.94576128
50	Insulin secretion_Homo sapiens_hsa04911	0.93268879
51	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.93113669
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.91089792
53	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.90680430
54	Collecting duct acid secretion_Homo sapiens_hsa04966	0.90493485
55	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.86574621
56	Primary immunodeficiency_Homo sapiens_hsa05340	0.84310594
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.83374191
58	Circadian entrainment_Homo sapiens_hsa04713	0.82956983
59	Asthma_Homo sapiens_hsa05310	0.81009676
60	Retinol metabolism_Homo sapiens_hsa00830	0.80394056
61	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.78676031
62	Purine metabolism_Homo sapiens_hsa00230	0.78554938
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.78103992
64	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.73252708
65	Metabolic pathways_Homo sapiens_hsa01100	0.72770786
66	Circadian rhythm_Homo sapiens_hsa04710	0.72695876
67	Fatty acid elongation_Homo sapiens_hsa00062	0.72060679
68	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.71412406
69	Glutamatergic synapse_Homo sapiens_hsa04724	0.68239599
70	ABC transporters_Homo sapiens_hsa02010	0.66365469
71	Serotonergic synapse_Homo sapiens_hsa04726	0.65729881
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64251228
73	Salivary secretion_Homo sapiens_hsa04970	0.63868457
74	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.62770399
75	Allograft rejection_Homo sapiens_hsa05330	0.60949565
76	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.57624390
77	Graft-versus-host disease_Homo sapiens_hsa05332	0.57127502
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.56518089
79	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.56449370
80	Pyrimidine metabolism_Homo sapiens_hsa00240	0.55826527
81	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.55794155
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.54636788
83	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.52972514
84	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.48536769
85	Dopaminergic synapse_Homo sapiens_hsa04728	0.46793540
86	Rheumatoid arthritis_Homo sapiens_hsa05323	0.44620647
87	Steroid biosynthesis_Homo sapiens_hsa00100	0.42266889
88	Cocaine addiction_Homo sapiens_hsa05030	0.41500513
89	Amphetamine addiction_Homo sapiens_hsa05031	0.41347917
90	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.40538670
91	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.39405072
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39252377
93	Calcium signaling pathway_Homo sapiens_hsa04020	0.38991373
94	Mineral absorption_Homo sapiens_hsa04978	0.38814206
95	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.37727455
96	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.35715529
97	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.32307665
98	Sulfur relay system_Homo sapiens_hsa04122	0.29278678
99	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.28364132
100	Glutathione metabolism_Homo sapiens_hsa00480	0.27502068

ARIH2OS

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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