ARL10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.68847487
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.33184127
3barbed-end actin filament capping (GO:0051016)4.95567152
4behavioral response to nicotine (GO:0035095)4.81456171
5postsynaptic membrane organization (GO:0001941)4.75994380
6cerebellar Purkinje cell layer development (GO:0021680)4.55896432
7presynaptic membrane assembly (GO:0097105)4.30092919
8nucleobase catabolic process (GO:0046113)4.09774147
9response to pheromone (GO:0019236)4.04626448
10presynaptic membrane organization (GO:0097090)3.96892664
11vocalization behavior (GO:0071625)3.86973959
12dosage compensation (GO:0007549)3.83057571
13synaptic vesicle maturation (GO:0016188)3.82788184
14negative regulation of erythrocyte differentiation (GO:0045647)3.82201538
15negative regulation of microtubule polymerization (GO:0031115)3.80346938
16neuron cell-cell adhesion (GO:0007158)3.80088707
17transmission of nerve impulse (GO:0019226)3.79852099
18peptidyl-arginine omega-N-methylation (GO:0035247)3.77036148
19gamma-aminobutyric acid transport (GO:0015812)3.74954217
20antigen processing and presentation via MHC class Ib (GO:0002475)3.74151895
21Arp2/3 complex-mediated actin nucleation (GO:0034314)3.72009259
22epithelial cell differentiation involved in prostate gland development (GO:0060742)3.65967062
23G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.64772490
24negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.53385502
25negative regulation of translation, ncRNA-mediated (GO:0040033)3.53385502
26regulation of translation, ncRNA-mediated (GO:0045974)3.53385502
27protein localization to synapse (GO:0035418)3.50944743
28regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.49526797
29N-glycan processing (GO:0006491)3.46982761
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.42364422
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.40090848
32nucleosome disassembly (GO:0006337)3.40044327
33protein-DNA complex disassembly (GO:0032986)3.40044327
34regulation of short-term neuronal synaptic plasticity (GO:0048172)3.39389843
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.35877766
36glutamate receptor signaling pathway (GO:0007215)3.35085325
37membrane depolarization during action potential (GO:0086010)3.33514171
38neuron recognition (GO:0008038)3.33343194
39peptidyl-arginine N-methylation (GO:0035246)3.29555853
40peptidyl-arginine methylation (GO:0018216)3.29555853
41auditory behavior (GO:0031223)3.27229070
42establishment of nucleus localization (GO:0040023)3.25588457
43central nervous system myelination (GO:0022010)3.20714049
44axon ensheathment in central nervous system (GO:0032291)3.20714049
45epithelial cell fate commitment (GO:0072148)3.19984373
46startle response (GO:0001964)3.19687256
47neuron projection extension involved in neuron projection guidance (GO:1902284)3.19095268
48axon extension involved in axon guidance (GO:0048846)3.19095268
49axonal fasciculation (GO:0007413)3.15627793
50negative regulation of myotube differentiation (GO:0010832)3.15023593
51synaptic transmission, glutamatergic (GO:0035249)3.11712460
52regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.11637207
53venous blood vessel morphogenesis (GO:0048845)3.10558754
54chaperone mediated protein folding requiring cofactor (GO:0051085)3.10484552
55histone H2A acetylation (GO:0043968)3.09037347
56spinal cord development (GO:0021510)3.08102269
57regulation of NFAT protein import into nucleus (GO:0051532)3.06339338
58nodal signaling pathway (GO:0038092)3.01131367
59actin nucleation (GO:0045010)3.00860908
60negative regulation of oligodendrocyte differentiation (GO:0048715)2.98586438
61nonmotile primary cilium assembly (GO:0035058)2.98238315
62platelet dense granule organization (GO:0060155)2.96519071
63positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.96113074
64neuromuscular synaptic transmission (GO:0007274)2.96098916
65behavioral response to ethanol (GO:0048149)2.95868491
66reflex (GO:0060004)2.95204381
67clathrin coat assembly (GO:0048268)2.94501486
68central nervous system projection neuron axonogenesis (GO:0021952)2.94423363
69kidney morphogenesis (GO:0060993)2.94014352
70negative regulation of cell size (GO:0045792)2.91348672
71mitochondrion transport along microtubule (GO:0047497)2.91197333
72establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.91197333
73regulation of gene silencing by miRNA (GO:0060964)2.91090416
74regulation of gene silencing by RNA (GO:0060966)2.91090416
75regulation of posttranscriptional gene silencing (GO:0060147)2.91090416
76synapse assembly (GO:0007416)2.90095216
77positive regulation of B cell differentiation (GO:0045579)2.90013987
78neuronal action potential (GO:0019228)2.88024031
79layer formation in cerebral cortex (GO:0021819)2.86148437
80cranial nerve morphogenesis (GO:0021602)2.84816636
81semaphorin-plexin signaling pathway (GO:0071526)2.82969017
82central nervous system neuron axonogenesis (GO:0021955)2.82061280
83regulation of synapse structural plasticity (GO:0051823)2.81326850
84cell migration involved in heart development (GO:0060973)2.81148054
85retinal ganglion cell axon guidance (GO:0031290)2.80826603
86mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.79012237
87regulation of erythrocyte differentiation (GO:0045646)2.78967593
88detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.77733056
89positive regulation of synapse assembly (GO:0051965)2.77236746
90response to auditory stimulus (GO:0010996)2.75420178
91serine transport (GO:0032329)2.74875396
92mechanosensory behavior (GO:0007638)2.74257166
93endosome to melanosome transport (GO:0035646)2.72283972
94endosome to pigment granule transport (GO:0043485)2.72283972
95spinal cord motor neuron differentiation (GO:0021522)2.70414014
96positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.69980957
97negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.69817451
98histone arginine methylation (GO:0034969)2.69172317
99positive regulation of synapse maturation (GO:0090129)2.68184346
100positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.66934622
101neuron-neuron synaptic transmission (GO:0007270)2.66799593
102appendage development (GO:0048736)2.64335026
103limb development (GO:0060173)2.64335026
104sympathetic nervous system development (GO:0048485)2.64054176
105urinary tract smooth muscle contraction (GO:0014848)2.63932597
106neuronal action potential propagation (GO:0019227)2.63785728
107regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.63204359
108negative regulation of cytosolic calcium ion concentration (GO:0051481)2.62545482
109Golgi transport vesicle coating (GO:0048200)2.62534128
110COPI coating of Golgi vesicle (GO:0048205)2.62534128
111DNA deamination (GO:0045006)2.62383447
112serotonin metabolic process (GO:0042428)2.61173450
113establishment of mitochondrion localization (GO:0051654)2.60862424
114negative regulation of axon guidance (GO:1902668)2.60671470
115behavioral defense response (GO:0002209)2.60298824
116behavioral fear response (GO:0001662)2.60298824
117cell migration in hindbrain (GO:0021535)2.60074391
118regulation of sarcomere organization (GO:0060297)2.57765226
119retrograde transport, endosome to Golgi (GO:0042147)2.55972292
120regulation of glutamate receptor signaling pathway (GO:1900449)2.55733784
121ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.55042166
122cell-cell junction maintenance (GO:0045217)2.54272193
123regulation of neurotransmitter uptake (GO:0051580)2.54232689
124growth hormone secretion (GO:0030252)2.53989372
125dendritic spine morphogenesis (GO:0060997)2.52743555
126immunoglobulin mediated immune response (GO:0016064)2.52345104
127membrane depolarization (GO:0051899)2.51329460
128regulation of early endosome to late endosome transport (GO:2000641)2.51129066
129facial nerve structural organization (GO:0021612)2.51070848
130peristalsis (GO:0030432)2.50961061
131fear response (GO:0042596)2.50866999
132tachykinin receptor signaling pathway (GO:0007217)2.50792163
133epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.50708359
134neurotransmitter-gated ion channel clustering (GO:0072578)2.50420132
135positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.50249896
136lung epithelium development (GO:0060428)2.50052620
137fucosylation (GO:0036065)2.50013935
138response to muramyl dipeptide (GO:0032495)2.49918525
139adult walking behavior (GO:0007628)2.49676558
140negative regulation of granulocyte differentiation (GO:0030853)2.49675960
141hindbrain development (GO:0030902)2.49056067
142somite development (GO:0061053)2.47904322
143regulation of action potential (GO:0098900)2.47419979
144neural tube development (GO:0021915)2.46989326
145inner ear receptor stereocilium organization (GO:0060122)2.46987045
146negative regulation of RNA splicing (GO:0033119)2.46149463
147head development (GO:0060322)2.45421447
148adult behavior (GO:0030534)2.44061513
149erythrocyte maturation (GO:0043249)2.43402273
150DNA unwinding involved in DNA replication (GO:0006268)2.43277440
151negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.43226082
152regulation of axon extension (GO:0030516)2.42981696
153calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.42949135
154synapse organization (GO:0050808)2.42647089
155heparin metabolic process (GO:0030202)2.42378299
156heparin biosynthetic process (GO:0030210)2.42378299
157regulation of synaptic transmission, glutamatergic (GO:0051966)2.42330842
158negative regulation of telomerase activity (GO:0051974)2.42125606
159regulation of respiratory system process (GO:0044065)2.41596213
160regulation of axon extension involved in axon guidance (GO:0048841)2.40701539
161de novo posttranslational protein folding (GO:0051084)2.40360538
162positive regulation of catecholamine secretion (GO:0033605)2.40069829
163regulation of B cell differentiation (GO:0045577)2.39749957
164DNA demethylation (GO:0080111)2.39632745
165cochlea development (GO:0090102)2.39089042
166gamma-aminobutyric acid signaling pathway (GO:0007214)2.39084810
167negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.39082248
168sodium ion export (GO:0071436)2.38266263
169negative regulation of gene expression, epigenetic (GO:0045814)2.37897513
170response to interferon-alpha (GO:0035455)2.37703994
171primary amino compound metabolic process (GO:1901160)2.37509208
172indolalkylamine metabolic process (GO:0006586)2.37186490
173regulation of protein heterodimerization activity (GO:0043497)2.36778437
174forebrain neuron differentiation (GO:0021879)2.36399302
175detection of light stimulus involved in sensory perception (GO:0050962)2.35282826
176detection of light stimulus involved in visual perception (GO:0050908)2.35282826
177lens fiber cell development (GO:0070307)2.35159066
178urogenital system development (GO:0001655)2.35025984
179negative regulation of synaptic transmission, GABAergic (GO:0032229)2.34815617
180regulation of synapse assembly (GO:0051963)2.33850769
181regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.33811745
182regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.33811745
183lateral sprouting from an epithelium (GO:0060601)2.33756805
184regulation of oligodendrocyte differentiation (GO:0048713)2.33591834
185mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.33586637
186neuronal stem cell maintenance (GO:0097150)2.33339996
187righting reflex (GO:0060013)2.33331093
188regulation of axon guidance (GO:1902667)2.33291824
189cell differentiation in spinal cord (GO:0021515)2.33165190
190dendrite morphogenesis (GO:0048813)2.32057904
191lipopolysaccharide biosynthetic process (GO:0009103)2.29405100
192regulation of defense response to virus by virus (GO:0050690)2.29156078

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.09669786
2MYC_22102868_ChIP-Seq_BL_Human3.78968256
3VDR_21846776_ChIP-Seq_THP-1_Human3.46363347
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.18021480
5GBX2_23144817_ChIP-Seq_PC3_Human3.17932054
6SCL_19346495_ChIP-Seq_HPC-7_Human2.74218758
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.72478407
8VDR_22108803_ChIP-Seq_LS180_Human2.65459357
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.63290805
10EZH2_22144423_ChIP-Seq_EOC_Human2.59669834
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.42551856
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.40742547
13ZNF274_21170338_ChIP-Seq_K562_Hela2.34830872
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33898349
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.27875388
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27018769
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.26361418
18LXR_22292898_ChIP-Seq_THP-1_Human2.25992916
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25205924
20ZFP281_18757296_ChIP-ChIP_E14_Mouse2.22561854
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.21888818
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21196337
23JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19874292
24KDM2B_26808549_Chip-Seq_DND41_Human2.13103158
25VDR_24763502_ChIP-Seq_THP-1_Human2.10634680
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.05817310
27TCF7_22412390_ChIP-Seq_EML_Mouse2.05729242
28REST_21632747_ChIP-Seq_MESCs_Mouse2.04807991
29CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04520838
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.04217588
31SRY_22984422_ChIP-ChIP_TESTIS_Rat2.03739166
32TAF15_26573619_Chip-Seq_HEK293_Human2.02837735
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.01642458
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00651366
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.98648385
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.97845146
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.97101844
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.96474037
39DROSHA_22980978_ChIP-Seq_HELA_Human1.95418904
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.95198856
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91428356
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.90437024
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89804983
44FUS_26573619_Chip-Seq_HEK293_Human1.87370557
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.86738978
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84555314
47P300_19829295_ChIP-Seq_ESCs_Human1.83341976
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.82984869
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.81078557
50AR_21572438_ChIP-Seq_LNCaP_Human1.80781229
51CIITA_25753668_ChIP-Seq_RAJI_Human1.80715661
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80096932
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.79234940
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79106327
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77025184
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76915526
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75051998
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73834439
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.73834439
60E2F7_22180533_ChIP-Seq_HELA_Human1.73358925
61EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72851390
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72851390
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72153419
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71311517
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70478004
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.69770031
67RNF2_27304074_Chip-Seq_NSC_Mouse1.67140938
68EWS_26573619_Chip-Seq_HEK293_Human1.63965217
69MYC_18555785_ChIP-Seq_MESCs_Mouse1.63802745
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.63480687
71SPI1_23127762_ChIP-Seq_K562_Human1.63292902
72SMAD4_21799915_ChIP-Seq_A2780_Human1.61291310
73MAF_26560356_Chip-Seq_TH1_Human1.61045147
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60455521
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60436845
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.58638904
77XRN2_22483619_ChIP-Seq_HELA_Human1.57383494
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57380326
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54510696
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54272057
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53949880
82SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52657491
83ELF1_20517297_ChIP-Seq_JURKAT_Human1.52054893
84RUNX1_22412390_ChIP-Seq_EML_Mouse1.51431881
85UTX_26944678_Chip-Seq_JUKART_Human1.49917256
86MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47500817
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.47328856
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47147261
89STAT3_23295773_ChIP-Seq_U87_Human1.45709868
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45314990
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44944420
92ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44704919
93DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44030589
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42396618
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41697164
96KDM2B_26808549_Chip-Seq_JURKAT_Human1.41589981
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41163660
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40477611
99SPI1_23547873_ChIP-Seq_NB4_Human1.38715845
100* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38463726
101FLI1_27457419_Chip-Seq_LIVER_Mouse1.38420707
102RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38327562
103SALL1_21062744_ChIP-ChIP_HESCs_Human1.38035741
104OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.36983099
105SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.35732952
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35577377
107BCAT_22108803_ChIP-Seq_LS180_Human1.35349930
108CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35038600
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34174306
110TCF4_23295773_ChIP-Seq_U87_Human1.33760148
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33743509
112KDM2B_26808549_Chip-Seq_K562_Human1.33507079
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32559937
114GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.32535103
115REST_18959480_ChIP-ChIP_MESCs_Mouse1.32496217
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32082824
117AR_25329375_ChIP-Seq_VCAP_Human1.31670337
118MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30986577
119CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29503212
120MTF2_20144788_ChIP-Seq_MESCs_Mouse1.29390194
121SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29361502
122NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29045467
123OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28714940
124IGF1R_20145208_ChIP-Seq_DFB_Human1.27974232
125CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27141078
126TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26483941
127BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25853765
128* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25779590
129RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.25317202
130* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23903149
131ER_23166858_ChIP-Seq_MCF-7_Human1.23115332
132RUNX2_22187159_ChIP-Seq_PCA_Human1.22982614
133PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22678866
134TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22651284
135MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22234348
136CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21514993
137SOX2_21211035_ChIP-Seq_LN229_Gbm1.21464770
138PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21431004
139DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20943362
140POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20048907
141* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20021942
142IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19075137
143CBP_20019798_ChIP-Seq_JUKART_Human1.19075137
144P68_20966046_ChIP-Seq_HELA_Human1.17813199
145* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17129937
146YY1_22570637_ChIP-Seq_MALME-3M_Human1.16880309
147RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16414900
148RING1B_27294783_Chip-Seq_ESCs_Mouse1.14063820
149DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12431922
150TET1_21451524_ChIP-Seq_MESCs_Mouse1.12260570
151KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11000024
152IRF8_21731497_ChIP-ChIP_J774_Mouse1.10699318
153TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10517753
154RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10334315
155SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10214751
156ZNF263_19887448_ChIP-Seq_K562_Human1.09994748
157SMAD3_21741376_ChIP-Seq_ESCs_Human1.09503987
158* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.09410906
159BCL6_27268052_Chip-Seq_Bcells_Human1.09402338
160LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08927164
161CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08659399
162EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08381725
163EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07953704
164CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07769018
165* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07679756
166KDM2B_26808549_Chip-Seq_REH_Human1.07649895
167THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07515272
168* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.06802203
169PRDM14_20953172_ChIP-Seq_ESCs_Human1.06727422
170SA1_27219007_Chip-Seq_ERYTHROID_Human1.06497287
171TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06458463
172TCF4_22108803_ChIP-Seq_LS180_Human1.06451658
173STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06299888
174CTCF_21964334_ChIP-Seq_BJAB-B_Human1.06230617
175TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05737338
176P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05646267
177IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05424815
178SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05309292
179STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04972944
180NANOG_18555785_Chip-Seq_ESCs_Mouse1.04942994
181NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04825942
182MAF_26560356_Chip-Seq_TH2_Human1.04519038
183AR_19668381_ChIP-Seq_PC3_Human1.04204358
184MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03779349
185KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03153132
186FOXM1_23109430_ChIP-Seq_U2OS_Human1.03031908
187ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02422532
188MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02181408
189TP63_19390658_ChIP-ChIP_HaCaT_Human1.01843778
190MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01839454
191FLI1_21867929_ChIP-Seq_TH2_Mouse1.01377831
192GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00944431
193SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00233022
194IRF8_22096565_ChIP-ChIP_GC-B_Human0.99309073
195LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99156372
196* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98064187

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.19282736
2MP0005423_abnormal_somatic_nervous3.63048195
3MP0003172_abnormal_lysosome_physiology3.44155016
4MP0010030_abnormal_orbit_morphology2.98768706
5MP0003183_abnormal_peptide_metabolism2.64450296
6MP0004859_abnormal_synaptic_plasticity2.62561965
7MP0002396_abnormal_hematopoietic_system2.60051365
8MP0003880_abnormal_central_pattern2.53242306
9MP0001968_abnormal_touch/_nociception2.44760263
10MP0009745_abnormal_behavioral_response2.41634188
11MP0000566_synostosis2.34102810
12MP0008961_abnormal_basal_metabolism2.33684044
13MP0002735_abnormal_chemical_nociception2.32401874
14MP0002736_abnormal_nociception_after2.32112759
15MP0005174_abnormal_tail_pigmentation2.31199915
16MP0009046_muscle_twitch2.22182978
17MP0003122_maternal_imprinting2.18244663
18MP0002089_abnormal_postnatal_growth/wei2.14349762
19MP0001486_abnormal_startle_reflex2.05786339
20MP0001835_abnormal_antigen_presentation2.03925052
21MP0002572_abnormal_emotion/affect_behav2.01649957
22MP0002734_abnormal_mechanical_nocicepti1.99041935
23MP0004142_abnormal_muscle_tone1.98408600
24MP0000685_abnormal_immune_system1.92221335
25MP0002272_abnormal_nervous_system1.90775998
26MP0002064_seizures1.88727893
27MP0004885_abnormal_endolymph1.88671759
28MP0003436_decreased_susceptibility_to1.88084075
29MP0006292_abnormal_olfactory_placode1.86662364
30MP0003136_yellow_coat_color1.86587260
31MP0009780_abnormal_chondrocyte_physiolo1.86004082
32MP0002822_catalepsy1.81548420
33MP0004145_abnormal_muscle_electrophysio1.78019849
34MP0003303_peritoneal_inflammation1.72641831
35MP0000371_diluted_coat_color1.72448319
36MP0005058_abnormal_lysosome_morphology1.70723719
37MP0006276_abnormal_autonomic_nervous1.70663964
38MP0004270_analgesia1.68872941
39MP0000778_abnormal_nervous_system1.67956786
40MP0002638_abnormal_pupillary_reflex1.65218842
41MP0001501_abnormal_sleep_pattern1.65017930
42MP0004133_heterotaxia1.64768408
43MP0004811_abnormal_neuron_physiology1.61664205
44MP0002067_abnormal_sensory_capabilities1.61607116
45MP0000631_abnormal_neuroendocrine_gland1.60049727
46MP0001485_abnormal_pinna_reflex1.58414601
47MP0005551_abnormal_eye_electrophysiolog1.55922524
48MP0003787_abnormal_imprinting1.54453689
49MP0001984_abnormal_olfaction1.54226194
50MP0000537_abnormal_urethra_morphology1.52487250
51MP0002938_white_spotting1.51839501
52MP0004808_abnormal_hematopoietic_stem1.51268427
53MP0005671_abnormal_response_to1.51172092
54MP0001188_hyperpigmentation1.50937003
55MP0008007_abnormal_cellular_replicative1.48660999
56MP0003283_abnormal_digestive_organ1.47033087
57MP0001440_abnormal_grooming_behavior1.46725757
58MP0002909_abnormal_adrenal_gland1.46608017
59MP0009278_abnormal_bone_marrow1.43872322
60MP0005076_abnormal_cell_differentiation1.42642136
61MP0005257_abnormal_intraocular_pressure1.39592405
62MP0006072_abnormal_retinal_apoptosis1.38540600
63MP0001529_abnormal_vocalization1.33345909
64MP0001545_abnormal_hematopoietic_system1.32566038
65MP0005397_hematopoietic_system_phenotyp1.32566038
66MP0001348_abnormal_lacrimal_gland1.31431576
67MP0002882_abnormal_neuron_morphology1.31387536
68MP0000465_gastrointestinal_hemorrhage1.30514467
69MP0005503_abnormal_tendon_morphology1.30173857
70MP0002419_abnormal_innate_immunity1.29770640
71MP0002752_abnormal_somatic_nervous1.29219769
72MP0005377_hearing/vestibular/ear_phenot1.28617085
73MP0003878_abnormal_ear_physiology1.28617085
74MP0000026_abnormal_inner_ear1.27786092
75MP0000049_abnormal_middle_ear1.27649365
76MP0004858_abnormal_nervous_system1.27094200
77MP0000955_abnormal_spinal_cord1.26908008
78MP0004742_abnormal_vestibular_system1.26467433
79MP0001905_abnormal_dopamine_level1.21608567
80MP0002452_abnormal_antigen_presenting1.20730609
81MP0003635_abnormal_synaptic_transmissio1.20474078
82MP0002398_abnormal_bone_marrow1.20161616
83MP0003119_abnormal_digestive_system1.19669468
84MP0003937_abnormal_limbs/digits/tail_de1.19660864
85MP0005464_abnormal_platelet_physiology1.19244757
86MP0003121_genomic_imprinting1.19122646
87MP0005025_abnormal_response_to1.19082720
88MP0004924_abnormal_behavior1.18473845
89MP0005386_behavior/neurological_phenoty1.18473845
90MP0001299_abnormal_eye_distance/1.18147577
91MP0005253_abnormal_eye_physiology1.17945428
92MP0003329_amyloid_beta_deposits1.17458924
93MP0010386_abnormal_urinary_bladder1.14787640
94MP0005646_abnormal_pituitary_gland1.14665916
95MP0005187_abnormal_penis_morphology1.13690370
96MP0000490_abnormal_crypts_of1.11509926
97MP0008872_abnormal_physiological_respon1.11477535
98MP0001819_abnormal_immune_cell1.10619284
99MP0001533_abnormal_skeleton_physiology1.10402480
100MP0008877_abnormal_DNA_methylation1.10399450
101MP0002420_abnormal_adaptive_immunity1.10106321
102MP0001963_abnormal_hearing_physiology1.09199460
103MP0003091_abnormal_cell_migration1.08642195
104MP0002184_abnormal_innervation1.06661757
105MP0005000_abnormal_immune_tolerance1.06314443
106MP0006054_spinal_hemorrhage1.05112700
107MP0003890_abnormal_embryonic-extraembry1.04228374
108MP0001958_emphysema1.04079341
109MP0003938_abnormal_ear_development1.03795588
110MP0003942_abnormal_urinary_system1.00172494
111MP0002928_abnormal_bile_duct0.99817824
112MP0001800_abnormal_humoral_immune0.98325359
113MP0000716_abnormal_immune_system0.97705882
114MP0002066_abnormal_motor_capabilities/c0.97296813
115MP0002723_abnormal_immune_serum0.96845877
116MP0002429_abnormal_blood_cell0.95470752
117MP0005195_abnormal_posterior_eye0.95146511
118MP0005197_abnormal_uvea_morphology0.94026451
119MP0000534_abnormal_ureter_morphology0.93749261
120MP0002095_abnormal_skin_pigmentation0.93061474
121MP0002075_abnormal_coat/hair_pigmentati0.93010024
122MP0003646_muscle_fatigue0.91992315
123MP0000350_abnormal_cell_proliferation0.91602536
124MP0009785_altered_susceptibility_to0.91126076
125MP0002733_abnormal_thermal_nociception0.90729500
126MP0002063_abnormal_learning/memory/cond0.90688544
127MP0000604_amyloidosis0.89909867
128MP0009250_abnormal_appendicular_skeleto0.89483158
129MP0009379_abnormal_foot_pigmentation0.89185332
130MP0003633_abnormal_nervous_system0.88668995
131MP0002933_joint_inflammation0.86515643
132MP0003634_abnormal_glial_cell0.85717191
133MP0001293_anophthalmia0.84544359
134MP0002722_abnormal_immune_system0.84379561
135MP0005075_abnormal_melanosome_morpholog0.84248458
136MP0002234_abnormal_pharynx_morphology0.83779909
137MP0000015_abnormal_ear_pigmentation0.83602667
138MP0002148_abnormal_hypersensitivity_rea0.83574671
139MP0001502_abnormal_circadian_rhythm0.83476586
140MP0000689_abnormal_spleen_morphology0.83251819
141MP0001286_abnormal_eye_development0.83218762
142MP0008770_decreased_survivor_rate0.83034416
143MP0003861_abnormal_nervous_system0.82862752
144MP0005171_absent_coat_pigmentation0.82143536
145MP0003755_abnormal_palate_morphology0.81776718
146MP0002249_abnormal_larynx_morphology0.81262404
147MP0001970_abnormal_pain_threshold0.81248099
148MP0002751_abnormal_autonomic_nervous0.80949773
149MP0008569_lethality_at_weaning0.80727241
150MP0003195_calcinosis0.80495763
151MP0005645_abnormal_hypothalamus_physiol0.80103944
152MP0002557_abnormal_social/conspecific_i0.79453621
153MP0000681_abnormal_thyroid_gland0.78852954
154MP0003631_nervous_system_phenotype0.78684877
155MP0003959_abnormal_lean_body0.78218190
156MP0002653_abnormal_ependyma_morphology0.77939916
157MP0004233_abnormal_muscle_weight0.77376946
158MP0001849_ear_inflammation0.76370625
159MP0005391_vision/eye_phenotype0.75716575
160MP0003077_abnormal_cell_cycle0.75604434
161MP0003385_abnormal_body_wall0.75249010
162MP0000313_abnormal_cell_death0.74084429
163MP0003123_paternal_imprinting0.73706229
164MP0002102_abnormal_ear_morphology0.73619387
165MP0009840_abnormal_foam_cell0.73367520
166MP0002152_abnormal_brain_morphology0.72628691
167MP0000703_abnormal_thymus_morphology0.71949405
168MP0003075_altered_response_to0.71879228
169MP0002092_abnormal_eye_morphology0.69685478

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)4.93256854
2Progressive cerebellar ataxia (HP:0002073)4.49454444
3Mutism (HP:0002300)4.46127874
4Hyperventilation (HP:0002883)4.03457128
5Hyperacusis (HP:0010780)3.77447033
6Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.45532601
7Diminished motivation (HP:0000745)3.29901740
8Broad-based gait (HP:0002136)3.23713329
9Pancreatic cysts (HP:0001737)3.20239593
10True hermaphroditism (HP:0010459)3.12423785
11Apathy (HP:0000741)3.11239751
12Supranuclear gaze palsy (HP:0000605)3.11085154
13Pancreatic fibrosis (HP:0100732)3.08599200
14Large eyes (HP:0001090)3.04407861
15Focal motor seizures (HP:0011153)3.03909091
16Nephronophthisis (HP:0000090)2.94741900
17Focal seizures (HP:0007359)2.94168340
18Congenital stationary night blindness (HP:0007642)2.93636332
19Papilledema (HP:0001085)2.91338007
20Elevated erythrocyte sedimentation rate (HP:0003565)2.87482580
21Febrile seizures (HP:0002373)2.85461254
22Molar tooth sign on MRI (HP:0002419)2.81151660
23Abnormality of midbrain morphology (HP:0002418)2.81151660
24Gaze-evoked nystagmus (HP:0000640)2.80638858
25Hematochezia (HP:0002573)2.74978945
26Drooling (HP:0002307)2.69511051
27Recurrent bacterial skin infections (HP:0005406)2.68562768
28Lissencephaly (HP:0001339)2.67751807
29Recurrent abscess formation (HP:0002722)2.67562574
30Atrophy/Degeneration involving motor neurons (HP:0007373)2.66759560
31Amyotrophic lateral sclerosis (HP:0007354)2.65341543
32Thrombocytosis (HP:0001894)2.64104909
33Protruding tongue (HP:0010808)2.61814167
34Insomnia (HP:0100785)2.52509014
35Abnormality of binocular vision (HP:0011514)2.51819781
36Diplopia (HP:0000651)2.51819781
37Abnormality of the renal medulla (HP:0100957)2.50892110
38Elfin facies (HP:0004428)2.50529203
39Morphological abnormality of the middle ear (HP:0008609)2.50176085
40Abnormality of the ischium (HP:0003174)2.47374811
41Bilateral microphthalmos (HP:0007633)2.46878742
42Spinal canal stenosis (HP:0003416)2.46575512
43Disinhibition (HP:0000734)2.44414945
44Hypoplastic ischia (HP:0003175)2.42461567
45Abnormality of the lumbar spine (HP:0100712)2.41558336
46Excessive salivation (HP:0003781)2.41529367
47Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.40646090
48Myokymia (HP:0002411)2.40580096
49Hemiparesis (HP:0001269)2.38912468
50Cortical dysplasia (HP:0002539)2.38379440
51Cutaneous finger syndactyly (HP:0010554)2.37949703
52Gait imbalance (HP:0002141)2.36860923
53Abnormality of glycolipid metabolism (HP:0010969)2.36828617
54Abnormality of liposaccharide metabolism (HP:0010968)2.36828617
55Abnormality of glycosphingolipid metabolism (HP:0004343)2.36828617
56Renal duplication (HP:0000075)2.34858534
57Epileptic encephalopathy (HP:0200134)2.33012647
58Inability to walk (HP:0002540)2.31194348
59Abnormal neuron morphology (HP:0012757)2.29828950
60Abnormality of the motor neurons (HP:0002450)2.29828950
61Ankle clonus (HP:0011448)2.29693292
62Sclerocornea (HP:0000647)2.29175545
63Keratoconus (HP:0000563)2.29113788
64Increased corneal curvature (HP:0100692)2.29113788
65Vaginal atresia (HP:0000148)2.28847119
66Cerebral aneurysm (HP:0004944)2.27099208
67Genital tract atresia (HP:0001827)2.26768837
68Polyphagia (HP:0002591)2.25925995
69Degeneration of anterior horn cells (HP:0002398)2.24709189
70Abnormality of the anterior horn cell (HP:0006802)2.24709189
71Large for gestational age (HP:0001520)2.24325197
72Dialeptic seizures (HP:0011146)2.24295625
73Loss of speech (HP:0002371)2.22606831
74Spinal muscular atrophy (HP:0007269)2.22165315
75Abnormality of the pubic bones (HP:0003172)2.21145954
76Medial flaring of the eyebrow (HP:0010747)2.20944420
77Striae distensae (HP:0001065)2.20481178
78Cystic liver disease (HP:0006706)2.20007258
79Visual hallucinations (HP:0002367)2.18167904
80Septo-optic dysplasia (HP:0100842)2.16480908
81Dysostosis multiplex (HP:0000943)2.15451310
82Increased nuchal translucency (HP:0010880)2.14800834
83Heterotopia (HP:0002282)2.13664695
84Abnormality of polysaccharide metabolism (HP:0011012)2.13270226
85Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13270226
86Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13270226
87Retinal dysplasia (HP:0007973)2.13076675
88Increased cerebral lipofuscin (HP:0011813)2.12729696
89Broad alveolar ridges (HP:0000187)2.12238052
90Mucopolysacchariduria (HP:0008155)2.11188677
91Urinary glycosaminoglycan excretion (HP:0003541)2.11188677
92Thoracic kyphosis (HP:0002942)2.10720365
93Broad face (HP:0000283)2.09570078
94Chronic hepatic failure (HP:0100626)2.09169138
95Pointed chin (HP:0000307)2.08877285
96Overriding aorta (HP:0002623)2.08819335
97Limb dystonia (HP:0002451)2.06665111
98Midline defect of the nose (HP:0004122)2.05827598
99Agitation (HP:0000713)2.05704299
100Arterial tortuosity (HP:0005116)2.05663972
101Optic nerve hypoplasia (HP:0000609)2.05308890
102Patellar aplasia (HP:0006443)2.04756928
103Type II lissencephaly (HP:0007260)2.04019684
104Intestinal atresia (HP:0011100)2.03413051
105Absent speech (HP:0001344)2.02512883
106Absence seizures (HP:0002121)2.01964907
107Interstitial pulmonary disease (HP:0006530)2.01611340
108Abnormality of the diencephalon (HP:0010662)2.01586233
109Anencephaly (HP:0002323)2.00707086
110Anophthalmia (HP:0000528)1.99180311
111Albinism (HP:0001022)1.98402883
112Aplasia/Hypoplasia of the tibia (HP:0005772)1.96782924
113Cutaneous syndactyly (HP:0012725)1.96726366
114Ependymoma (HP:0002888)1.92786746
115Congenital primary aphakia (HP:0007707)1.91329859
116Attenuation of retinal blood vessels (HP:0007843)1.90959155
117Iris hypopigmentation (HP:0007730)1.89912177
118Abnormality of the thoracic spine (HP:0100711)1.89880684
119Aplasia/Hypoplasia of the patella (HP:0006498)1.87501948
120Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85400643
121Bowel diverticulosis (HP:0005222)1.85269209
122Progressive neurologic deterioration (HP:0002344)1.85002914
123Polydipsia (HP:0001959)1.84877787
124Abnormal drinking behavior (HP:0030082)1.84877787
125Decreased central vision (HP:0007663)1.82780618
126Hypoplasia of the brainstem (HP:0002365)1.81681277
127Aplasia/Hypoplasia of the brainstem (HP:0007362)1.81681277
128Shawl scrotum (HP:0000049)1.80247476
129Alacrima (HP:0000522)1.80147559
130Agnosia (HP:0010524)1.79300004
131Epileptiform EEG discharges (HP:0011182)1.79253487
132Pachygyria (HP:0001302)1.78949133
133Megalocornea (HP:0000485)1.78594726
134Atonic seizures (HP:0010819)1.78578796
135Action tremor (HP:0002345)1.78577110
136Abolished electroretinogram (ERG) (HP:0000550)1.77724354
137Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.77579355
138Inappropriate behavior (HP:0000719)1.76864295
139Colon cancer (HP:0003003)1.76237096
140Tubular atrophy (HP:0000092)1.76149302
141Orthostatic hypotension (HP:0001278)1.75349828
142Urinary bladder sphincter dysfunction (HP:0002839)1.75228640
143Exotropia (HP:0000577)1.74824747
144Hand muscle atrophy (HP:0009130)1.73696531
145Long palpebral fissure (HP:0000637)1.73547042
146Myositis (HP:0100614)1.73504646
147Renovascular hypertension (HP:0100817)1.72692512
148Oligodactyly (hands) (HP:0001180)1.72626532
149Nephrogenic diabetes insipidus (HP:0009806)1.72609996
150Short foot (HP:0001773)1.72588872
151Narrow nasal bridge (HP:0000446)1.72361026
152Vascular tortuosity (HP:0004948)1.72049551
153Cupped ear (HP:0000378)1.71613742
154Open mouth (HP:0000194)1.71254845
155Partial agenesis of the corpus callosum (HP:0001338)1.71195212
156Pendular nystagmus (HP:0012043)1.71057062
157Impaired smooth pursuit (HP:0007772)1.70270352
158Increased neuronal autofluorescent lipopigment (HP:0002074)1.70246988
159Aplasia/Hypoplasia of the sternum (HP:0006714)1.70017548
160Spondylolisthesis (HP:0003302)1.69838895
161Congenital, generalized hypertrichosis (HP:0004540)1.69419207
162Neoplasm of the heart (HP:0100544)1.69317115
163EEG with generalized epileptiform discharges (HP:0011198)1.69249496
164Chorioretinal atrophy (HP:0000533)1.69227483
165Fatigue (HP:0012378)1.69034161
166Progressive inability to walk (HP:0002505)1.68822820
167Failure to thrive in infancy (HP:0001531)1.67739029
168Highly arched eyebrow (HP:0002553)1.65720261
169Personality changes (HP:0000751)1.65712310
170Clumsiness (HP:0002312)1.65264949
171Protrusio acetabuli (HP:0003179)1.65023574
172Bony spicule pigmentary retinopathy (HP:0007737)1.64313055
173Hypsarrhythmia (HP:0002521)1.64171680
174Neuronal loss in central nervous system (HP:0002529)1.63918008
175Short 4th metacarpal (HP:0010044)1.63791151
176Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.63791151
177Poor head control (HP:0002421)1.63781666
178Broad palm (HP:0001169)1.63367401
179Widely spaced teeth (HP:0000687)1.63352634
180Poor coordination (HP:0002370)1.63343471
181Abnormality of the labia minora (HP:0012880)1.63257948
182Radial bowing (HP:0002986)1.63049410
183Depression (HP:0000716)1.62932057
184Chest pain (HP:0100749)1.62764189
185Abnormality of the 4th metacarpal (HP:0010012)1.61914643
186Torticollis (HP:0000473)1.61091786
187Small hand (HP:0200055)1.60915776
188Cellulitis (HP:0100658)1.60641824
189Preaxial foot polydactyly (HP:0001841)1.60346528
190Urinary urgency (HP:0000012)1.60329174
191Cerebral hypomyelination (HP:0006808)1.59615111
192Tented upper lip vermilion (HP:0010804)1.58742522
193Limb-girdle muscle atrophy (HP:0003797)1.58292381
194Abnormality of the astrocytes (HP:0100707)1.57914705
195Astrocytoma (HP:0009592)1.57914705

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.61051568
2CASK4.30089405
3MARK13.66644722
4MKNK23.51295911
5MAP3K102.97511211
6SIK32.94557018
7INSRR2.71889167
8BUB12.71806088
9PNCK2.53783278
10ERN12.53605936
11MAP3K92.44269448
12SCYL22.37928676
13KSR12.30295976
14NTRK32.28664070
15EEF2K2.17542477
16TESK22.03198149
17FLT32.02571720
18ADRBK22.01595985
19MKNK11.91685697
20CSF1R1.87895653
21DYRK21.86749516
22NTRK21.86711133
23KIT1.81913898
24MAP3K41.79960541
25BLK1.69653884
26UHMK11.68584525
27TGFBR11.56635819
28PAK41.51685627
29GRK11.48625908
30TGFBR21.48482104
31SIK21.47823839
32MINK11.46033610
33PRKCG1.42688312
34TNIK1.37318871
35BTK1.25520923
36CDK191.25395509
37TBK11.23203494
38LRRK21.18285570
39ACVR1B1.18256206
40PINK11.18087841
41PKN21.17191833
42DYRK31.17035262
43ZAK1.15759364
44MAP2K71.15430148
45TRIB31.09049486
46NTRK11.07801461
47MAP4K11.07720423
48MATK1.07719539
49DYRK1A1.04698498
50NUAK11.03931246
51SGK21.03766013
52SGK2231.02662315
53SGK4941.02662315
54LIMK11.00981666
55KSR21.00643986
56DAPK20.99947042
57MAPK150.98566960
58PKN10.98148118
59WNK30.98002825
60ADRBK10.97434722
61EPHB20.96749894
62CDK180.95461208
63PAK60.93851200
64PIM20.93493170
65SYK0.93145064
66STK38L0.92975831
67CSNK1G20.91726998
68PRKCH0.90524869
69EPHA40.88954926
70WNK40.87137022
71CAMKK20.87026497
72PRKCE0.84656002
73ERBB30.84456087
74CDC70.83539984
75FGFR20.83369003
76PDGFRA0.83298026
77MAPK130.81585951
78TYRO30.81467361
79CDK150.81221166
80FGFR30.79266518
81CAMK2A0.78158761
82CDK80.78098696
83AKT30.77494125
84PHKG10.76410687
85PHKG20.76410687
86CDK11A0.76315835
87CDK140.76083205
88DYRK1B0.75608353
89PAK30.73825887
90FES0.73144531
91FGFR10.72841890
92TLK10.72112340
93PLK20.71879404
94STK100.71290361
95OXSR10.71281905
96PAK20.69643086
97TYK20.68294612
98RPS6KA20.68016741
99CAMK10.67567852
100RAF10.67069507
101PRKG20.66034886
102ERBB20.65781234
103ZAP700.65132068
104STK110.64850623
105JAK30.63800404
106CAMKK10.63688143
107MAP4K20.63290992
108MARK20.62386759
109MAPK40.61420829
110CSNK1G10.61099952
111BMPR1B0.60951791
112WNK10.60798034
113OBSCN0.60750187
114TESK10.58621544
115MAPK90.56862000
116NEK20.56749377
117ICK0.56447650
118VRK10.55476043
119CAMK40.55337129
120CDK30.55243686
121PRKCZ0.55102303
122TEC0.54925285
123MTOR0.54800867
124BCR0.54193259
125CDK50.53544081
126ATR0.53527116
127RIPK10.52761377
128SGK10.52692097
129NME10.51481984
130CDK120.51324056
131LYN0.51297532
132PTK60.51254456
133PRKAA10.49040025
134MAP3K130.49011187
135TIE10.48260733
136STK390.47908549
137RET0.47811325
138BRSK10.47744552
139CAMK1D0.47518055
140ARAF0.47080381
141CSNK1A1L0.44703545
142AKT20.44342400
143CHEK20.44327117
144MAP3K70.43875084
145HIPK20.43321785
146CSNK1D0.43080204
147CAMK2B0.42565572
148CSNK1A10.42358986
149MAP2K40.40445013
150ALK0.40371247
151LATS10.39916535
152CAMK1G0.39697317
153PRKACA0.39696714
154PRKD30.39285507
155HCK0.38565663
156MAP3K80.38098209
157CSNK1E0.36749021
158TAF10.36686571
159FYN0.36167641
160CLK10.35827377
161MAP3K120.35773457
162CSNK1G30.35612841
163PRKG10.34998947
164SGK30.33986365
165GSK3B0.32523751
166RPS6KA30.32301006
167BRD40.30699160

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.20314047
2Notch signaling pathway_Homo sapiens_hsa043302.74644211
3Morphine addiction_Homo sapiens_hsa050322.60804386
4Glutamatergic synapse_Homo sapiens_hsa047242.56367663
5Taste transduction_Homo sapiens_hsa047422.52217055
6Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.44263036
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.42406117
8Circadian entrainment_Homo sapiens_hsa047132.42127253
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.42078373
10GABAergic synapse_Homo sapiens_hsa047272.39298682
11N-Glycan biosynthesis_Homo sapiens_hsa005102.35733753
12Phototransduction_Homo sapiens_hsa047442.21750010
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.14609397
14Cardiac muscle contraction_Homo sapiens_hsa042602.06694035
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.99290614
16Colorectal cancer_Homo sapiens_hsa052101.98985458
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.91891993
18Cholinergic synapse_Homo sapiens_hsa047251.86055220
19Butanoate metabolism_Homo sapiens_hsa006501.84613506
20Insulin secretion_Homo sapiens_hsa049111.80878591
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.79315323
22Dopaminergic synapse_Homo sapiens_hsa047281.79173699
23Serotonergic synapse_Homo sapiens_hsa047261.75424944
24B cell receptor signaling pathway_Homo sapiens_hsa046621.74974851
25Chronic myeloid leukemia_Homo sapiens_hsa052201.73570814
26Neurotrophin signaling pathway_Homo sapiens_hsa047221.69901865
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.65278679
28Leishmaniasis_Homo sapiens_hsa051401.62073645
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.58240326
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.56279855
31Shigellosis_Homo sapiens_hsa051311.55895890
32Oxidative phosphorylation_Homo sapiens_hsa001901.54329362
33Lysosome_Homo sapiens_hsa041421.52261610
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48825386
35Hedgehog signaling pathway_Homo sapiens_hsa043401.48573523
36RNA polymerase_Homo sapiens_hsa030201.45376947
37Selenocompound metabolism_Homo sapiens_hsa004501.43333964
38Amphetamine addiction_Homo sapiens_hsa050311.41571192
39DNA replication_Homo sapiens_hsa030301.40071890
40Olfactory transduction_Homo sapiens_hsa047401.39518817
41Spliceosome_Homo sapiens_hsa030401.38703774
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.38440862
43Calcium signaling pathway_Homo sapiens_hsa040201.34594066
44Acute myeloid leukemia_Homo sapiens_hsa052211.33835780
45Base excision repair_Homo sapiens_hsa034101.33060252
46Parkinsons disease_Homo sapiens_hsa050121.33023311
47Prion diseases_Homo sapiens_hsa050201.31081233
48Salmonella infection_Homo sapiens_hsa051321.30571756
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27580221
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.27005014
51Osteoclast differentiation_Homo sapiens_hsa043801.25841443
52Oxytocin signaling pathway_Homo sapiens_hsa049211.24259054
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24199120
54Linoleic acid metabolism_Homo sapiens_hsa005911.22556827
55Pancreatic cancer_Homo sapiens_hsa052121.21573147
56Nitrogen metabolism_Homo sapiens_hsa009101.20504976
57Long-term depression_Homo sapiens_hsa047301.20136637
58Axon guidance_Homo sapiens_hsa043601.19555545
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18094221
60Other glycan degradation_Homo sapiens_hsa005111.16197781
61Gastric acid secretion_Homo sapiens_hsa049711.15695352
62cAMP signaling pathway_Homo sapiens_hsa040241.14677902
63Huntingtons disease_Homo sapiens_hsa050161.13903608
64Endometrial cancer_Homo sapiens_hsa052131.13376554
65Alzheimers disease_Homo sapiens_hsa050101.13070920
66Central carbon metabolism in cancer_Homo sapiens_hsa052301.11502593
67Dorso-ventral axis formation_Homo sapiens_hsa043201.10338484
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06123848
69Pertussis_Homo sapiens_hsa051331.06009746
70Salivary secretion_Homo sapiens_hsa049701.04096215
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03970278
72Tryptophan metabolism_Homo sapiens_hsa003801.03901275
73Viral myocarditis_Homo sapiens_hsa054161.02613775
74Non-small cell lung cancer_Homo sapiens_hsa052231.02399549
75Bladder cancer_Homo sapiens_hsa052191.02084821
76Apoptosis_Homo sapiens_hsa042101.00911028
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.99934392
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98618674
79Endocytosis_Homo sapiens_hsa041440.98189958
80Lysine degradation_Homo sapiens_hsa003100.97551721
81Alcoholism_Homo sapiens_hsa050340.97106447
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96454869
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96250869
84MicroRNAs in cancer_Homo sapiens_hsa052060.96124843
85Basal transcription factors_Homo sapiens_hsa030220.95278849
86Dilated cardiomyopathy_Homo sapiens_hsa054140.95107749
87Phagosome_Homo sapiens_hsa041450.94746620
88Hepatitis B_Homo sapiens_hsa051610.94306851
89VEGF signaling pathway_Homo sapiens_hsa043700.93850559
90Viral carcinogenesis_Homo sapiens_hsa052030.93804288
91Legionellosis_Homo sapiens_hsa051340.93589447
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93555736
93Basal cell carcinoma_Homo sapiens_hsa052170.93518767
94Renin secretion_Homo sapiens_hsa049240.93252500
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91584510
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90645081
97Ether lipid metabolism_Homo sapiens_hsa005650.90568420
98Protein export_Homo sapiens_hsa030600.88422962
99Gap junction_Homo sapiens_hsa045400.88162953
100Ovarian steroidogenesis_Homo sapiens_hsa049130.87856889
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87560709
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86071644
103Synaptic vesicle cycle_Homo sapiens_hsa047210.85930676
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85903386
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85661686
106Cell cycle_Homo sapiens_hsa041100.85424006
107Renal cell carcinoma_Homo sapiens_hsa052110.85249619
108HTLV-I infection_Homo sapiens_hsa051660.84844745
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84315420
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84001309
111Glioma_Homo sapiens_hsa052140.83920515
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83351584
113Epstein-Barr virus infection_Homo sapiens_hsa051690.83346650
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83273605
115Melanogenesis_Homo sapiens_hsa049160.81588426
116Prolactin signaling pathway_Homo sapiens_hsa049170.79582091
117Homologous recombination_Homo sapiens_hsa034400.77683853
118Tuberculosis_Homo sapiens_hsa051520.77587160
119mTOR signaling pathway_Homo sapiens_hsa041500.77192378
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76260254
121Proteoglycans in cancer_Homo sapiens_hsa052050.74789332
122Platelet activation_Homo sapiens_hsa046110.74246880
123Pathways in cancer_Homo sapiens_hsa052000.72825374
124ErbB signaling pathway_Homo sapiens_hsa040120.71385475
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71176262
126Fanconi anemia pathway_Homo sapiens_hsa034600.70139173
127Antigen processing and presentation_Homo sapiens_hsa046120.68353007
128Chemokine signaling pathway_Homo sapiens_hsa040620.68270704
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67848376
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67258911
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66573114
132Hippo signaling pathway_Homo sapiens_hsa043900.66244583
133Influenza A_Homo sapiens_hsa051640.66084797
134Circadian rhythm_Homo sapiens_hsa047100.65280630
135Estrogen signaling pathway_Homo sapiens_hsa049150.65233476
136Ras signaling pathway_Homo sapiens_hsa040140.64752912
137Long-term potentiation_Homo sapiens_hsa047200.64350223
138MAPK signaling pathway_Homo sapiens_hsa040100.62434430
139RNA degradation_Homo sapiens_hsa030180.61723227
140ABC transporters_Homo sapiens_hsa020100.61654252
141Type II diabetes mellitus_Homo sapiens_hsa049300.59541805
142Herpes simplex infection_Homo sapiens_hsa051680.59002453
143Glycerolipid metabolism_Homo sapiens_hsa005610.58689506
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58559492
145Cocaine addiction_Homo sapiens_hsa050300.58502201
146Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58498737
147Sphingolipid signaling pathway_Homo sapiens_hsa040710.58166611
148Jak-STAT signaling pathway_Homo sapiens_hsa046300.57616784
149Vibrio cholerae infection_Homo sapiens_hsa051100.57204086
150Toxoplasmosis_Homo sapiens_hsa051450.57028162
151Phospholipase D signaling pathway_Homo sapiens_hsa040720.56677646
152Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56484911
153Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56000523
154Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55852595
155Measles_Homo sapiens_hsa051620.55610683
156RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55138848
157Propanoate metabolism_Homo sapiens_hsa006400.54990135
158Sulfur relay system_Homo sapiens_hsa041220.53935858
159Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53838457
160Melanoma_Homo sapiens_hsa052180.53469216
161Renin-angiotensin system_Homo sapiens_hsa046140.53268620
162Systemic lupus erythematosus_Homo sapiens_hsa053220.53039785
163TNF signaling pathway_Homo sapiens_hsa046680.51891873
164Thyroid cancer_Homo sapiens_hsa052160.51063342
165Mismatch repair_Homo sapiens_hsa034300.50949249
166Wnt signaling pathway_Homo sapiens_hsa043100.50942126
167Small cell lung cancer_Homo sapiens_hsa052220.49975605
168Leukocyte transendothelial migration_Homo sapiens_hsa046700.49430356
169TGF-beta signaling pathway_Homo sapiens_hsa043500.48869897
170Protein digestion and absorption_Homo sapiens_hsa049740.45450137
171Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42773645
172Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42227216
173Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40907430
174Rap1 signaling pathway_Homo sapiens_hsa040150.40075640
175Pancreatic secretion_Homo sapiens_hsa049720.39878441
176Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39062868
177beta-Alanine metabolism_Homo sapiens_hsa004100.39030699
178ECM-receptor interaction_Homo sapiens_hsa045120.38469753
179Thyroid hormone synthesis_Homo sapiens_hsa049180.32977615
180Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32166064
181Purine metabolism_Homo sapiens_hsa002300.30391581

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