ARL11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.41741309
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.97201455
3modulation by symbiont of host immune response (GO:0052553)5.96070311
4positive regulation by symbiont of host defense response (GO:0052509)5.96070311
5modulation by symbiont of host defense response (GO:0052031)5.96070311
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.96070311
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.96070311
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.96070311
9respiratory burst (GO:0045730)5.89679583
10regulation of interferon-beta biosynthetic process (GO:0045357)5.56821648
11regulation of B cell receptor signaling pathway (GO:0050855)5.41407436
12neutrophil mediated immunity (GO:0002446)5.17058257
13positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.09062269
14immunoglobulin mediated immune response (GO:0016064)4.97305356
15regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.88464188
16negative regulation of phagocytosis (GO:0050765)4.58448202
17response to peptidoglycan (GO:0032494)4.57892590
18macrophage activation involved in immune response (GO:0002281)4.55481180
19neutrophil activation (GO:0042119)4.38018582
20reactive oxygen species biosynthetic process (GO:1903409)4.37787918
21negative regulation of interleukin-12 production (GO:0032695)4.26869253
22positive regulation of interferon-alpha production (GO:0032727)4.24026610
23Arp2/3 complex-mediated actin nucleation (GO:0034314)4.22776780
24response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.17938414
25response to host immune response (GO:0052572)4.17938414
26pinocytosis (GO:0006907)4.17676303
27granulocyte activation (GO:0036230)4.15735319
28regulation of gamma-delta T cell activation (GO:0046643)4.13970837
29response to fungus (GO:0009620)4.12792850
30detection of other organism (GO:0098543)4.12628429
31disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.10792358
32killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.10792358
33myeloid cell activation involved in immune response (GO:0002275)4.10363195
34production of molecular mediator involved in inflammatory response (GO:0002532)4.07526817
35positive regulation of mast cell activation (GO:0033005)4.05160647
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.01005517
37antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.01005517
38positive regulation of antigen processing and presentation (GO:0002579)3.98888615
39regulation of interferon-alpha production (GO:0032647)3.98495059
40myeloid leukocyte mediated immunity (GO:0002444)3.95614219
41detection of molecule of bacterial origin (GO:0032490)3.93272251
42regulation of mast cell activation (GO:0033003)3.91826399
43regulation of mast cell degranulation (GO:0043304)3.87144750
44detection of bacterium (GO:0016045)3.80255378
45positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.80178875
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.77659575
47response to host (GO:0075136)3.77659575
48response to host defenses (GO:0052200)3.77659575
49leukocyte mediated cytotoxicity (GO:0001909)3.77622945
50hydrogen peroxide biosynthetic process (GO:0050665)3.77245454
51negative regulation of lymphocyte mediated immunity (GO:0002707)3.72691008
52superoxide anion generation (GO:0042554)3.72030298
53leukocyte aggregation (GO:0070486)3.71983225
54detection of external biotic stimulus (GO:0098581)3.70027706
55B cell mediated immunity (GO:0019724)3.67579370
56antigen processing and presentation of endogenous antigen (GO:0019883)3.66151541
57regulation of gamma-delta T cell differentiation (GO:0045586)3.65184339
58defense response to fungus (GO:0050832)3.64411481
59negative regulation of T cell mediated immunity (GO:0002710)3.59563810
60regulation of mast cell activation involved in immune response (GO:0033006)3.57806565
61positive regulation of B cell differentiation (GO:0045579)3.56435370
62mast cell activation (GO:0045576)3.56407420
63cellular response to zinc ion (GO:0071294)3.55069869
64cellular extravasation (GO:0045123)3.48683006
65regulation of interleukin-8 biosynthetic process (GO:0045414)3.48298840
66microglial cell activation (GO:0001774)3.46055174
67cellular response to interleukin-15 (GO:0071350)3.45940725
68response to interleukin-15 (GO:0070672)3.43067339
69modulation of growth of symbiont involved in interaction with host (GO:0044144)3.42096628
70regulation of growth of symbiont in host (GO:0044126)3.42096628
71negative regulation of growth of symbiont in host (GO:0044130)3.42096628
72negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.42096628
73negative regulation of mast cell activation (GO:0033004)3.42046241
74regulation of leukocyte degranulation (GO:0043300)3.42027376
75regulation of antigen processing and presentation (GO:0002577)3.39328954
76positive regulation of mast cell activation involved in immune response (GO:0033008)3.35767751
77positive regulation of mast cell degranulation (GO:0043306)3.35767751
78regulation of myeloid leukocyte mediated immunity (GO:0002886)3.34193419
79macrophage activation (GO:0042116)3.33683110
80regulation of B cell differentiation (GO:0045577)3.33482081
81positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.31197023
82regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.28748331
83detection of biotic stimulus (GO:0009595)3.28135781
84leukocyte migration involved in inflammatory response (GO:0002523)3.27484883
85positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.26953117
86activated T cell proliferation (GO:0050798)3.24463766
87actin nucleation (GO:0045010)3.24292232
88negative regulation of leukocyte mediated immunity (GO:0002704)3.23853558
89positive regulation of gamma-delta T cell activation (GO:0046645)3.19806010
90defense response to protozoan (GO:0042832)3.19588710
91phagosome maturation (GO:0090382)3.16682493
92negative thymic T cell selection (GO:0045060)3.16220616
93negative T cell selection (GO:0043383)3.15486852
94negative regulation of myeloid cell apoptotic process (GO:0033033)3.13746748
95interferon-gamma-mediated signaling pathway (GO:0060333)3.12545464
96leukotriene metabolic process (GO:0006691)3.11860709
97interferon-gamma production (GO:0032609)3.09763543
98myeloid leukocyte activation (GO:0002274)3.09705489
99negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.08670911
100leukocyte degranulation (GO:0043299)3.08514651
101DNA deamination (GO:0045006)3.03234428
102neutrophil chemotaxis (GO:0030593)2.97745899
103disruption of cells of other organism (GO:0044364)2.97363529
104killing of cells of other organism (GO:0031640)2.97363529
105regulation of alpha-beta T cell proliferation (GO:0046640)2.94989882
106positive regulation of interferon-beta production (GO:0032728)2.94029719
107cellular response to thyroid hormone stimulus (GO:0097067)2.93885710
108B cell receptor signaling pathway (GO:0050853)2.93575026
109response to protozoan (GO:0001562)2.92898457
110regulation of T cell mediated cytotoxicity (GO:0001914)2.91868119
111response to type I interferon (GO:0034340)2.91285534
112negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.90325902
113type I interferon signaling pathway (GO:0060337)2.89767421
114cellular response to type I interferon (GO:0071357)2.89767421
115neutrophil migration (GO:1990266)2.89073518
116regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.87916608
117negative regulation of interleukin-17 production (GO:0032700)2.87306837
118positive thymic T cell selection (GO:0045059)2.87189356
119myeloid dendritic cell activation (GO:0001773)2.86963749
120macrophage differentiation (GO:0030225)2.86614042
121positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.86341240
122mast cell activation involved in immune response (GO:0002279)2.86320574
123mast cell degranulation (GO:0043303)2.86320574
124positive regulation of T cell mediated cytotoxicity (GO:0001916)2.86319350
125angiogenesis involved in wound healing (GO:0060055)2.84634219
126positive regulation of interleukin-1 beta secretion (GO:0050718)2.84149444
127leukocyte mediated immunity (GO:0002443)2.83457025
128positive regulation of leukocyte degranulation (GO:0043302)2.82172404
129response to muramyl dipeptide (GO:0032495)2.81840155
130regulation of interleukin-6 biosynthetic process (GO:0045408)2.81719411
131negative regulation of cell killing (GO:0031342)2.80951686
132negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.80951686
133dendritic cell differentiation (GO:0097028)2.80833999
134natural killer cell mediated immunity (GO:0002228)2.80658014
135natural killer cell mediated cytotoxicity (GO:0042267)2.80658014
136negative regulation of innate immune response (GO:0045824)2.80498539
137negative regulation of granulocyte differentiation (GO:0030853)2.80053583
138negative regulation of interleukin-1 production (GO:0032692)2.79118866
139negative regulation of adaptive immune response (GO:0002820)2.78471931
140regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.78281262
141response to interferon-beta (GO:0035456)2.78263585

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.61743431
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.63643800
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.63431141
4E2F7_22180533_ChIP-Seq_HELA_Human4.58208987
5MYB_21317192_ChIP-Seq_ERMYB_Mouse3.79687209
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.78540961
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.72442456
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.71863897
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.40147576
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.14906166
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.99571152
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.85848397
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.78306386
14* SPI1_23547873_ChIP-Seq_NB4_Human2.72507534
15VDR_21846776_ChIP-Seq_THP-1_Human2.65521308
16SCL_19346495_ChIP-Seq_HPC-7_Human2.64072043
17* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.63610672
18* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.60568572
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.54920128
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.54065441
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.39693852
22ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.23706384
23VDR_24763502_ChIP-Seq_THP-1_Human2.23174739
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.17966311
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.17059791
26* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.12685942
27* RUNX1_22412390_ChIP-Seq_EML_Mouse2.11153570
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.02894199
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.96433310
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.93289681
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.89307063
32MYB_26560356_Chip-Seq_TH2_Human1.88471362
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.88091737
34SPI1_23127762_ChIP-Seq_K562_Human1.86816230
35SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.79121399
36PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.75015838
37PU_27001747_Chip-Seq_BMDM_Mouse1.74057182
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73743117
39MYC_22102868_ChIP-Seq_BL_Human1.68851151
40MAF_26560356_Chip-Seq_TH1_Human1.68349587
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67064062
42CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.65883318
43ZNF274_21170338_ChIP-Seq_K562_Hela1.64747778
44CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57891124
45* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.56793640
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.53823854
47MYB_26560356_Chip-Seq_TH1_Human1.51829324
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50289313
49UTX_26944678_Chip-Seq_JUKART_Human1.48719195
50GATA1_22383799_ChIP-Seq_G1ME_Mouse1.48603900
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47321171
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46956956
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.43896018
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42915317
55CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42300120
56* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41915295
57TFEB_21752829_ChIP-Seq_HELA_Human1.40832283
58GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.38607591
59CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35902399
60E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34646242
61* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34258870
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32651151
63SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32085624
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.31276450
65E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30957330
66RUNX_20019798_ChIP-Seq_JUKART_Human1.30437492
67TCF7_22412390_ChIP-Seq_EML_Mouse1.28916752
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24839332
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22805978
70VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.22277416
71SMRT_27268052_Chip-Seq_Bcells_Human1.20845687
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18962031
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18679532
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18565568
75IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15353680
76GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14437720
77GATA3_27048872_Chip-Seq_THYMUS_Human1.12711663
78RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10885778
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09806484
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08822723
81GATA3_26560356_Chip-Seq_TH2_Human1.08791898
82VDR_24787735_ChIP-Seq_THP-1_Human1.04932076
83FLI1_27457419_Chip-Seq_LIVER_Mouse1.02678742
84NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00790368
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99211477
86ER_23166858_ChIP-Seq_MCF-7_Human0.97848254
87MAF_26560356_Chip-Seq_TH2_Human0.97116199
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96775605
89EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96269626
90GATA1_19941827_ChIP-Seq_MEL_Mouse0.96253075
91PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95114355
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94868693
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94318372
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.93349879
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93043407
96FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.92815425
97PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92663773
98GATA3_26560356_Chip-Seq_TH1_Human0.92445060
99* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91988260
100SPI1_20517297_ChIP-Seq_HL60_Human0.91470080
101SMAD_19615063_ChIP-ChIP_OVARY_Human0.90527709
102ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90488715
103ELK3_25401928_ChIP-Seq_HUVEC_Human0.90474715
104GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.89885456
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89263788
106EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89137742
107E2F1_21310950_ChIP-Seq_MCF-7_Human0.88983010
108GATA1_22025678_ChIP-Seq_K562_Human0.87885259
109KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87014373
110EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86863581
111VDR_23849224_ChIP-Seq_CD4+_Human0.86554390
112TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86517679
113P300_27268052_Chip-Seq_Bcells_Human0.84317047
114IRF1_19129219_ChIP-ChIP_H3396_Human0.84254276
115VDR_22108803_ChIP-Seq_LS180_Human0.83582915
116VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83093327
117STAT1_20625510_ChIP-Seq_HELA_Human0.81538763
118GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80903789
119CIITA_25753668_ChIP-Seq_RAJI_Human0.80058262
120NANOG_20526341_ChIP-Seq_ESCs_Human0.79934682
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78432990
122RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77719968
123EST1_17652178_ChIP-ChIP_JURKAT_Human0.77054047
124FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.76430442
125BCL6_27268052_Chip-Seq_Bcells_Human0.75050146
126MYC_18555785_ChIP-Seq_MESCs_Mouse0.74721980
127FOXP3_21729870_ChIP-Seq_TREG_Human0.73364703
128TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72964308
129FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72127129
130GABP_17652178_ChIP-ChIP_JURKAT_Human0.71921309
131ELK1_19687146_ChIP-ChIP_HELA_Human0.71898982
132KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.71189379

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.26750395
2MP0003436_decreased_susceptibility_to3.97632446
3MP0005058_abnormal_lysosome_morphology3.93106202
4MP0003303_peritoneal_inflammation3.47508508
5MP0002419_abnormal_innate_immunity3.37958730
6MP0003172_abnormal_lysosome_physiology3.27086991
7MP0009785_altered_susceptibility_to3.02729493
8MP0002148_abnormal_hypersensitivity_rea2.93561281
9MP0005000_abnormal_immune_tolerance2.82517154
10MP0005025_abnormal_response_to2.80297114
11MP0002452_abnormal_antigen_presenting2.56131634
12MP0006082_CNS_inflammation2.54493178
13MP0005464_abnormal_platelet_physiology2.42943820
14MP0002396_abnormal_hematopoietic_system2.32045517
15MP0002723_abnormal_immune_serum2.30324539
16MP0001819_abnormal_immune_cell2.29919334
17MP0002420_abnormal_adaptive_immunity2.29873527
18MP0003191_abnormal_cellular_cholesterol2.26479736
19MP0001800_abnormal_humoral_immune2.26226080
20MP0005174_abnormal_tail_pigmentation2.20591800
21MP0001790_abnormal_immune_system2.20392481
22MP0005387_immune_system_phenotype2.20392481
23MP0003724_increased_susceptibility_to2.18584038
24MP0000685_abnormal_immune_system2.18156251
25MP0005671_abnormal_response_to2.08636225
26MP0001853_heart_inflammation2.03634999
27MP0001533_abnormal_skeleton_physiology2.01355296
28MP0002405_respiratory_system_inflammati2.01031047
29MP0003183_abnormal_peptide_metabolism1.96251194
30MP0009840_abnormal_foam_cell1.93159642
31MP0000343_altered_response_to1.91412474
32MP0001845_abnormal_inflammatory_respons1.82147393
33MP0000465_gastrointestinal_hemorrhage1.78997600
34MP0000716_abnormal_immune_system1.76471152
35MP0002398_abnormal_bone_marrow1.73564012
36MP0005397_hematopoietic_system_phenotyp1.73180024
37MP0001545_abnormal_hematopoietic_system1.73180024
38MP0002166_altered_tumor_susceptibility1.69218117
39MP0004510_myositis1.67717577
40MP0000689_abnormal_spleen_morphology1.65001503
41MP0000858_altered_metastatic_potential1.61489137
42MP0010307_abnormal_tumor_latency1.61282736
43MP0008469_abnormal_protein_level1.56446533
44MP0009278_abnormal_bone_marrow1.56237882
45MP0003300_gastrointestinal_ulcer1.55886668
46MP0002429_abnormal_blood_cell1.52725234
47MP0009333_abnormal_splenocyte_physiolog1.51025658
48MP0003448_altered_tumor_morphology1.50700974
49MP0003075_altered_response_to1.50045909
50MP0002722_abnormal_immune_system1.47549219
51MP0010155_abnormal_intestine_physiology1.43070980
52MP0000569_abnormal_digit_pigmentation1.41506116
53MP0003195_calcinosis1.41293894
54MP0002006_tumorigenesis1.40016791
55MP0005310_abnormal_salivary_gland1.39124550
56MP0003787_abnormal_imprinting1.37203506
57MP0000490_abnormal_crypts_of1.36317813
58MP0000015_abnormal_ear_pigmentation1.33409989
59MP0004808_abnormal_hematopoietic_stem1.33193772
60MP0002132_abnormal_respiratory_system1.28886961
61MP0008877_abnormal_DNA_methylation1.28485430
62MP0003806_abnormal_nucleotide_metabolis1.26223227
63MP0001986_abnormal_taste_sensitivity1.25892780
64MP0000604_amyloidosis1.25798092
65MP0002653_abnormal_ependyma_morphology1.24298905
66MP0003690_abnormal_glial_cell1.23891562
67MP0002998_abnormal_bone_remodeling1.18832821
68MP0001851_eye_inflammation1.15421031
69MP0009764_decreased_sensitivity_to1.15004754
70MP0004947_skin_inflammation1.14134095
71MP0003656_abnormal_erythrocyte_physiolo1.13925651
72MP0004381_abnormal_hair_follicle1.12554341
73MP0001873_stomach_inflammation1.12178303
74MP0003186_abnormal_redox_activity1.10313846
75MP0005166_decreased_susceptibility_to1.07904912
76MP0002933_joint_inflammation1.07639660
77MP0002138_abnormal_hepatobiliary_system1.01640510
78MP0002095_abnormal_skin_pigmentation0.92385270
79MP0008260_abnormal_autophagy0.92288413
80MP0005257_abnormal_intraocular_pressure0.91079343
81MP0003828_pulmonary_edema0.91034351
82MP0005390_skeleton_phenotype0.89547554
83MP0003646_muscle_fatigue0.88193632
84MP0003763_abnormal_thymus_physiology0.87158749
85MP0003693_abnormal_embryo_hatching0.84922878
86MP0000703_abnormal_thymus_morphology0.84905134
87MP0003566_abnormal_cell_adhesion0.84833359
88MP0004782_abnormal_surfactant_physiolog0.84149683
89MP0009763_increased_sensitivity_to0.82120083
90MP0003866_abnormal_defecation0.81638978
91MP0002019_abnormal_tumor_incidence0.80851383
92MP0005164_abnormal_response_to0.78326915
93MP0000371_diluted_coat_color0.77979788
94MP0001663_abnormal_digestive_system0.77338728
95MP0005084_abnormal_gallbladder_morpholo0.76251566
96MP0000249_abnormal_blood_vessel0.76164271
97MP0003795_abnormal_bone_structure0.73333746
98MP0002693_abnormal_pancreas_physiology0.71988720
99MP0005075_abnormal_melanosome_morpholog0.71650518
100MP0003878_abnormal_ear_physiology0.70606376
101MP0005377_hearing/vestibular/ear_phenot0.70606376
102MP0009765_abnormal_xenobiotic_induced0.70294555
103MP0002928_abnormal_bile_duct0.69521572
104MP0005167_abnormal_blood-brain_barrier0.67237368
105MP0010094_abnormal_chromosome_stability0.65158315
106MP0008873_increased_physiological_sensi0.64711610
107MP0008007_abnormal_cellular_replicative0.64599405
108MP0006054_spinal_hemorrhage0.64257424
109MP0004883_abnormal_blood_vessel0.62308710
110MP0000920_abnormal_myelination0.61689603
111MP0000598_abnormal_liver_morphology0.60810686
112MP0000313_abnormal_cell_death0.57942984
113MP0002277_abnormal_respiratory_mucosa0.55638686
114MP0001501_abnormal_sleep_pattern0.55318584
115MP0003077_abnormal_cell_cycle0.53925366
116MP0004130_abnormal_muscle_cell0.53859873
117MP0005319_abnormal_enzyme/_coenzyme0.53534955
118MP0000372_irregular_coat_pigmentation0.53119828
119MP0003111_abnormal_nucleus_morphology0.52510383
120MP0003045_fibrosis0.51488273
121MP0000609_abnormal_liver_physiology0.50882376
122MP0008872_abnormal_physiological_respon0.49219447
123MP0004742_abnormal_vestibular_system0.48907800

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.55766045
2Eczematoid dermatitis (HP:0000976)6.95091729
3Recurrent bacterial skin infections (HP:0005406)6.73789484
4Recurrent gram-negative bacterial infections (HP:0005420)6.00675604
5Increased cerebral lipofuscin (HP:0011813)5.81530240
6Vacuolated lymphocytes (HP:0001922)5.38215100
7Increased neuronal autofluorescent lipopigment (HP:0002074)5.35050269
8Abnormality of macrophages (HP:0004311)5.23646834
9Chronic obstructive pulmonary disease (HP:0006510)4.86290846
10Obstructive lung disease (HP:0006536)4.86290846
11Myositis (HP:0100614)4.31649734
12Mediastinal lymphadenopathy (HP:0100721)4.10181240
13Dysostosis multiplex (HP:0000943)4.09164781
14Abnormal delayed hypersensitivity skin test (HP:0002963)4.06160306
15Abnormality of glycolipid metabolism (HP:0010969)4.01953927
16Abnormality of liposaccharide metabolism (HP:0010968)4.01953927
17Abnormality of glycosphingolipid metabolism (HP:0004343)4.01953927
18Recurrent skin infections (HP:0001581)3.92740103
19Gingivitis (HP:0000230)3.86285491
20Disinhibition (HP:0000734)3.69011192
21Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.66313152
22Encephalitis (HP:0002383)3.65805209
23Elevated erythrocyte sedimentation rate (HP:0003565)3.62161788
24Agnosia (HP:0010524)3.56088037
25Mucopolysacchariduria (HP:0008155)3.53173303
26Urinary glycosaminoglycan excretion (HP:0003541)3.53173303
27Recurrent fungal infections (HP:0002841)3.47567673
28Axonal loss (HP:0003447)3.44666307
29Keratoconjunctivitis (HP:0001096)3.40383571
30Panhypogammaglobulinemia (HP:0003139)3.35648236
31Systemic lupus erythematosus (HP:0002725)3.31890672
32Abnormality of T cell number (HP:0011839)3.30713895
33Abnormality of polysaccharide metabolism (HP:0011012)3.29381861
34Abnormality of glycosaminoglycan metabolism (HP:0004371)3.29381861
35Abnormality of mucopolysaccharide metabolism (HP:0011020)3.29381861
36T lymphocytopenia (HP:0005403)3.25136826
37Orchitis (HP:0100796)3.24063118
38Cellulitis (HP:0100658)3.23805555
39Gastrointestinal infarctions (HP:0005244)3.09001207
40Loss of speech (HP:0002371)3.06266476
41Thrombocytosis (HP:0001894)3.05118700
42Stomatitis (HP:0010280)3.01597797
43Meningitis (HP:0001287)3.00625407
44Abnormality of T cells (HP:0002843)2.93660684
45Urticaria (HP:0001025)2.85269117
46Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.81721110
47Periodontitis (HP:0000704)2.79866862
48J-shaped sella turcica (HP:0002680)2.79725284
49Agammaglobulinemia (HP:0004432)2.78765973
50Hepatosplenomegaly (HP:0001433)2.77640308
51Chronic otitis media (HP:0000389)2.73232863
52Recurrent viral infections (HP:0004429)2.73215132
53Autoimmune thrombocytopenia (HP:0001973)2.72586436
54Petechiae (HP:0000967)2.71966664
55Optic neuritis (HP:0100653)2.67020901
56Retrobulbar optic neuritis (HP:0100654)2.67020901
57Spontaneous hematomas (HP:0007420)2.64766794
58Osteomyelitis (HP:0002754)2.61096911
59Abnormality of B cell number (HP:0010975)2.60831798
60IgM deficiency (HP:0002850)2.60543518
61Anorexia (HP:0002039)2.56030055
62Thoracic kyphosis (HP:0002942)2.53131339
63Hypochromic anemia (HP:0001931)2.51264219
64Upper motor neuron abnormality (HP:0002127)2.50588466
65Increased IgM level (HP:0003496)2.50474316
66Hypochromic microcytic anemia (HP:0004840)2.47685011
67Abnormality of eosinophils (HP:0001879)2.47500673
68Stomach cancer (HP:0012126)2.47036241
69Recurrent pneumonia (HP:0006532)2.46974028
70Basal ganglia calcification (HP:0002135)2.45933612
71Interstitial pulmonary disease (HP:0006530)2.44838573
72Episodic fever (HP:0001954)2.44643294
73Severe combined immunodeficiency (HP:0004430)2.43089188
74Vasculitis (HP:0002633)2.41176341
75Pustule (HP:0200039)2.41066975
76Papilledema (HP:0001085)2.39692872
77Increased IgE level (HP:0003212)2.39685427
78IgG deficiency (HP:0004315)2.39633184
79Thyroiditis (HP:0100646)2.32630263
80Pulmonary embolism (HP:0002204)2.29251448
81Glomerulonephritis (HP:0000099)2.28769817
82Absent rod-and cone-mediated responses on ERG (HP:0007688)2.25029509
83Abnormality of the lumbar spine (HP:0100712)2.23127096
84Abnormality of the prostate (HP:0008775)2.19612165
85Albinism (HP:0001022)2.17564844
86Abnormality of the thoracic spine (HP:0100711)2.16664465
87Pulmonary infiltrates (HP:0002113)2.16476522
88Chronic mucocutaneous candidiasis (HP:0002728)2.14340541
89Recurrent cutaneous fungal infections (HP:0011370)2.14340541
90Diminished motivation (HP:0000745)2.14186730
91Sepsis (HP:0100806)2.13774676
92Recurrent bronchitis (HP:0002837)2.12970592
93Epistaxis (HP:0000421)2.12383871
94B lymphocytopenia (HP:0010976)2.12290760
95Gangrene (HP:0100758)2.11596470
96Hemoptysis (HP:0002105)2.10456543
97Leukocytosis (HP:0001974)2.10233727
98Microcytic anemia (HP:0001935)2.10155706
99Abnormality of the vasculature of the conjunctiva (HP:0008054)2.08067219
100Pathologic fracture (HP:0002756)2.05685422
101Chest pain (HP:0100749)2.04151363
102Joint hemorrhage (HP:0005261)2.03505185
103Autoimmune hemolytic anemia (HP:0001890)2.02648664
104Prolonged bleeding time (HP:0003010)2.01507406
105Recurrent lower respiratory tract infections (HP:0002783)2.01157048
106Poor head control (HP:0002421)2.01027457
107Inflammation of the large intestine (HP:0002037)1.99046223
108Reduced antithrombin III activity (HP:0001976)1.98107768
109Vertigo (HP:0002321)1.97840859
110Keratitis (HP:0000491)1.97691517
111Hematochezia (HP:0002573)1.97371516
112Recurrent sinusitis (HP:0011108)1.97322732
113Combined immunodeficiency (HP:0005387)1.96876485
114Abnormal rod and cone electroretinograms (HP:0008323)1.95590307
115Lymphopenia (HP:0001888)1.95385044
116Abolished electroretinogram (ERG) (HP:0000550)1.95354125
117Congenital stationary night blindness (HP:0007642)1.92701798
118Eosinophilia (HP:0001880)1.92564525
119Polyneuropathy (HP:0001271)1.92541866
120Abnormal platelet function (HP:0011869)1.90916553
121Impaired platelet aggregation (HP:0003540)1.90916553
122Progressive neurologic deterioration (HP:0002344)1.89969570
123Deformed sella turcica (HP:0002681)1.89717104
124Apathy (HP:0000741)1.89341960
125Skin ulcer (HP:0200042)1.88815104
126Decreased electroretinogram (ERG) amplitude (HP:0000654)1.88749695
127Gingival bleeding (HP:0000225)1.87953413
128Inappropriate behavior (HP:0000719)1.86856520
129Skin rash (HP:0000988)1.86336031
130Gastrointestinal inflammation (HP:0004386)1.86048973
131Arterial thrombosis (HP:0004420)1.84700567
132Keratoconjunctivitis sicca (HP:0001097)1.84081224
133Attenuation of retinal blood vessels (HP:0007843)1.83564624
134Abnormality of cells of the lymphoid lineage (HP:0012140)1.82365506
135Abnormality of the pleura (HP:0002103)1.80742770
136Granulocytopenia (HP:0001913)1.80477935
137Personality changes (HP:0000751)1.80404133
138Prostate neoplasm (HP:0100787)1.80216240
139Abnormality of the endocardium (HP:0004306)1.76958419
140Hypergammaglobulinemia (HP:0010702)1.76841247
141Abnormality of T cell physiology (HP:0011840)1.73696429
142Myocardial infarction (HP:0001658)1.73386807
143Nasal polyposis (HP:0100582)1.70667579

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK44.00051751
2KIT3.72627315
3BLK3.34653787
4MAP4K13.16901900
5RIPK42.98457827
6FRK2.77887047
7ERN12.52748551
8TBK12.45744708
9TYK22.37483848
10BTK2.17284772
11FES2.14889419
12TEC2.13246035
13CSF1R2.03509097
14TNK21.98969144
15PIM21.80939337
16NME21.77244473
17MAP3K141.77014384
18TAOK31.76672609
19TGFBR21.72912478
20SYK1.72370806
21MAP2K31.69880914
22CLK11.64997604
23IRAK31.60641572
24IKBKE1.60563573
25FLT31.57971631
26PKN21.57657924
27MAP3K121.46995048
28ZAP701.46400116
29HCK1.46184511
30LYN1.40392970
31IKBKB1.37971315
32STK101.37907329
33TXK1.34257446
34SCYL21.33307432
35CSK1.31446023
36NEK91.31037816
37NUAK11.31004236
38JAK11.24109664
39MATK1.22956191
40PINK11.22592074
41PBK1.21981221
42ITK1.21485833
43PAK41.20646242
44TESK21.19404857
45TLK11.19072506
46MAP4K21.18046730
47IRAK11.16728480
48BCKDK1.16722124
49GRK61.16460870
50BMPR1B1.13020875
51CAMKK21.12287716
52JAK31.09837920
53LCK1.06316262
54EIF2AK31.05405687
55TRPM71.05220163
56PIM11.05161118
57LRRK21.03524564
58ABL21.03395876
59GRK11.02406471
60MAP2K61.00954215
61STK41.00855936
62PRKCQ0.99745138
63EPHB10.99042821
64DAPK20.98831572
65CDK190.94295462
66BMPR20.89601390
67RPS6KA40.88528088
68TESK10.87608870
69OXSR10.84713255
70JAK20.81791225
71MAP3K130.78755312
72TRIB30.77276451
73PTK2B0.76182612
74ZAK0.75904998
75PRKCD0.74150217
76RPS6KA60.73696817
77FGR0.72431817
78NEK20.71409078
79CDK60.71147004
80TAOK10.70736035
81MAP3K110.70416366
82WEE10.69107338
83CDC70.67820456
84RPS6KC10.67700343
85RPS6KL10.67700343
86KDR0.66902875
87STK160.62926922
88DAPK10.60334819
89WNK30.59603274
90TTN0.59263853
91MAPK40.57977731
92CAMKK10.57960726
93SIK20.57488575
94MARK30.57298460
95EPHA30.56651291
96MAP3K10.56036612
97STK110.55185916
98NLK0.55072680
99MAPK130.54776909
100MAP3K80.54774640
101EEF2K0.53793056
102MAP2K40.53518350
103CDK40.53300384
104BRSK20.53081379
105ABL10.52681491
106MAP2K20.52391865
107GRK70.52288406
108CAMK1D0.51262877
109YES10.51259753
110RPS6KA20.48515476
111EGFR0.47671424
112ADRBK10.46740845
113EIF2AK10.46658204
114EIF2AK20.46411055
115BUB10.43859979
116FYN0.43677097
117MAPKAPK20.43090236
118ATR0.42920947
119PRKD20.42088030
120CHUK0.41146687
121ERBB30.40712721
122MAP3K30.40477538
123CDK70.39677782
124ACVR1B0.39557248
125PDK10.39452619
126FGFR30.39069569
127MAP3K50.38294717
128ADRBK20.38177220
129MAP3K60.38150050
130PTK60.38051074
131MAPK120.36875068
132IRAK20.35283509
133MARK20.33139552
134TGFBR10.32884356
135PRKCZ0.32717019
136PIK3CG0.32237160
137SIK30.31258973
138MAP3K70.31149828
139HIPK20.26719501
140PDPK10.26324314
141CAMK40.22362767
142MAPK70.21992040
143WNK10.21676291
144IGF1R0.21305342

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.79445041
2Lysosome_Homo sapiens_hsa041423.42131312
3Leishmaniasis_Homo sapiens_hsa051403.33467516
4Other glycan degradation_Homo sapiens_hsa005113.28029771
5Autoimmune thyroid disease_Homo sapiens_hsa053202.97049640
6Staphylococcus aureus infection_Homo sapiens_hsa051502.95059297
7Type I diabetes mellitus_Homo sapiens_hsa049402.61693340
8Osteoclast differentiation_Homo sapiens_hsa043802.54618659
9Tuberculosis_Homo sapiens_hsa051522.27611014
10Phagosome_Homo sapiens_hsa041452.23980607
11DNA replication_Homo sapiens_hsa030302.17592107
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.12953739
13Pertussis_Homo sapiens_hsa051332.10009417
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.97361735
15Legionellosis_Homo sapiens_hsa051341.89558838
16B cell receptor signaling pathway_Homo sapiens_hsa046621.87295284
17Antigen processing and presentation_Homo sapiens_hsa046121.86347147
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.76309866
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71254570
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69800434
21Measles_Homo sapiens_hsa051621.61968100
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.61209990
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.56871841
24Shigellosis_Homo sapiens_hsa051311.51657100
25Salmonella infection_Homo sapiens_hsa051321.45715174
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.43796736
27Malaria_Homo sapiens_hsa051441.40555422
28Apoptosis_Homo sapiens_hsa042101.40014008
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37879353
30Base excision repair_Homo sapiens_hsa034101.36105061
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33866669
32Rheumatoid arthritis_Homo sapiens_hsa053231.33407261
33Hematopoietic cell lineage_Homo sapiens_hsa046401.30750903
34Influenza A_Homo sapiens_hsa051641.30608897
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.29671103
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27250270
37Herpes simplex infection_Homo sapiens_hsa051681.26899244
38Asthma_Homo sapiens_hsa053101.25766180
39Mismatch repair_Homo sapiens_hsa034301.25122041
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24633102
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24135152
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.22259616
43Toxoplasmosis_Homo sapiens_hsa051451.20951492
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15830593
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14423827
46Chemokine signaling pathway_Homo sapiens_hsa040621.08813535
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06462554
48Pentose phosphate pathway_Homo sapiens_hsa000301.03553509
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02043128
50Hepatitis B_Homo sapiens_hsa051611.00629313
51Renin-angiotensin system_Homo sapiens_hsa046140.98173779
52Primary immunodeficiency_Homo sapiens_hsa053400.96711655
53Homologous recombination_Homo sapiens_hsa034400.96149481
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.95265568
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92316470
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91158253
57Ribosome_Homo sapiens_hsa030100.90670088
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88119946
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87838874
60Platelet activation_Homo sapiens_hsa046110.87254964
61Ether lipid metabolism_Homo sapiens_hsa005650.85693545
62Linoleic acid metabolism_Homo sapiens_hsa005910.85560810
63N-Glycan biosynthesis_Homo sapiens_hsa005100.84421965
64Acute myeloid leukemia_Homo sapiens_hsa052210.84403534
65Non-homologous end-joining_Homo sapiens_hsa034500.84062110
66Viral myocarditis_Homo sapiens_hsa054160.77443954
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76772413
68Regulation of autophagy_Homo sapiens_hsa041400.75974965
69Allograft rejection_Homo sapiens_hsa053300.75856284
70TNF signaling pathway_Homo sapiens_hsa046680.74047859
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73727500
72Arachidonic acid metabolism_Homo sapiens_hsa005900.73387660
73Chronic myeloid leukemia_Homo sapiens_hsa052200.73302398
74Sphingolipid metabolism_Homo sapiens_hsa006000.71517014
75Galactose metabolism_Homo sapiens_hsa000520.71510253
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69307949
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69251678
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67806984
79Collecting duct acid secretion_Homo sapiens_hsa049660.65492667
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65404304
81Proteasome_Homo sapiens_hsa030500.64664612
82Pancreatic cancer_Homo sapiens_hsa052120.64464646
83Complement and coagulation cascades_Homo sapiens_hsa046100.64411995
84Phototransduction_Homo sapiens_hsa047440.63706472
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.61951939
86Epstein-Barr virus infection_Homo sapiens_hsa051690.61334074
87Hepatitis C_Homo sapiens_hsa051600.58900164
88Dorso-ventral axis formation_Homo sapiens_hsa043200.58475823
89Nucleotide excision repair_Homo sapiens_hsa034200.58000556
90Caffeine metabolism_Homo sapiens_hsa002320.56328176
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.51921028
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51868630
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.50088297
94Graft-versus-host disease_Homo sapiens_hsa053320.49389523
95Olfactory transduction_Homo sapiens_hsa047400.48649770
96Viral carcinogenesis_Homo sapiens_hsa052030.46958660
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44499837
98HIF-1 signaling pathway_Homo sapiens_hsa040660.43184937
99Amoebiasis_Homo sapiens_hsa051460.43175043
100p53 signaling pathway_Homo sapiens_hsa041150.42239650
101T cell receptor signaling pathway_Homo sapiens_hsa046600.41892414
102Endocytosis_Homo sapiens_hsa041440.41561670
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41256797
104Non-small cell lung cancer_Homo sapiens_hsa052230.38033280
105Prolactin signaling pathway_Homo sapiens_hsa049170.36971167
106Pyrimidine metabolism_Homo sapiens_hsa002400.36922321
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35474608
108ABC transporters_Homo sapiens_hsa020100.33387238
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33345032
110Starch and sucrose metabolism_Homo sapiens_hsa005000.33217873
111Cell cycle_Homo sapiens_hsa041100.32280159
112Nitrogen metabolism_Homo sapiens_hsa009100.31934691
113African trypanosomiasis_Homo sapiens_hsa051430.31679146
114Systemic lupus erythematosus_Homo sapiens_hsa053220.30467845
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30460021
116VEGF signaling pathway_Homo sapiens_hsa043700.30382810
117Vibrio cholerae infection_Homo sapiens_hsa051100.29734944
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29651908
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27558192
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.27072386
121Type II diabetes mellitus_Homo sapiens_hsa049300.26064917
122Tryptophan metabolism_Homo sapiens_hsa003800.25914216
123FoxO signaling pathway_Homo sapiens_hsa040680.21045677
124Morphine addiction_Homo sapiens_hsa050320.20387603
125Peroxisome_Homo sapiens_hsa041460.20048870
126Glycerolipid metabolism_Homo sapiens_hsa005610.19366285
127MAPK signaling pathway_Homo sapiens_hsa040100.16264443
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.15722535
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13577813
130Insulin resistance_Homo sapiens_hsa049310.12828297
131Selenocompound metabolism_Homo sapiens_hsa004500.12071929
132Ovarian steroidogenesis_Homo sapiens_hsa049130.11187613

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