ARL13B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADP-ribosylation factor-like family. The encoded protein is a small GTPase that contains both N-terminal and C-terminal guanine nucleotide-binding motifs. This protein is localized in the cilia and plays a role in cilia formation and in maintenance of cilia. Mutations in this gene are the cause of Joubert syndrome 8. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)4.54854329
2axonemal dynein complex assembly (GO:0070286)4.51593334
3cilium or flagellum-dependent cell motility (GO:0001539)4.46110379
4CENP-A containing nucleosome assembly (GO:0034080)4.43937413
5centriole replication (GO:0007099)4.43517105
6negative regulation of neurotransmitter secretion (GO:0046929)4.40415132
7cilium movement (GO:0003341)4.14628617
8protein localization to endosome (GO:0036010)4.06378813
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.05586324
10hemidesmosome assembly (GO:0031581)4.03924737
11epithelial cilium movement (GO:0003351)3.90279926
12detection of light stimulus involved in sensory perception (GO:0050962)3.72067507
13detection of light stimulus involved in visual perception (GO:0050908)3.72067507
14protein localization to kinetochore (GO:0034501)3.66963646
15histone exchange (GO:0043486)3.66662435
16fusion of sperm to egg plasma membrane (GO:0007342)3.63870506
17intraciliary transport (GO:0042073)3.63611590
18axon ensheathment in central nervous system (GO:0032291)3.61341003
19central nervous system myelination (GO:0022010)3.61341003
20DNA replication checkpoint (GO:0000076)3.58379031
21kinetochore organization (GO:0051383)3.56502428
22resolution of meiotic recombination intermediates (GO:0000712)3.50229992
23negative regulation of inclusion body assembly (GO:0090084)3.47228618
24eye photoreceptor cell differentiation (GO:0001754)3.46577225
25photoreceptor cell differentiation (GO:0046530)3.46577225
26replication fork processing (GO:0031297)3.45648417
27multicellular organism reproduction (GO:0032504)3.44127075
28piRNA metabolic process (GO:0034587)3.41593679
29regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.39351575
30regulation of mitotic spindle checkpoint (GO:1903504)3.39351575
31DNA replication-independent nucleosome organization (GO:0034724)3.32342496
32DNA replication-independent nucleosome assembly (GO:0006336)3.32342496
33cell wall macromolecule catabolic process (GO:0016998)3.24678750
34cell wall macromolecule metabolic process (GO:0044036)3.24678750
35exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.24615441
36lateral sprouting from an epithelium (GO:0060601)3.23112331
37metaphase plate congression (GO:0051310)3.22814349
38meiotic chromosome segregation (GO:0045132)3.21326119
39regulation of rhodopsin mediated signaling pathway (GO:0022400)3.21071729
40protein K6-linked ubiquitination (GO:0085020)3.19101891
41desmosome organization (GO:0002934)3.18368657
42mitotic metaphase plate congression (GO:0007080)3.16099412
43telomere maintenance via semi-conservative replication (GO:0032201)3.13756312
44ventricular system development (GO:0021591)3.13561875
45nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.12919692
46rhodopsin mediated signaling pathway (GO:0016056)3.07547613
47protein localization to chromosome, centromeric region (GO:0071459)3.05669040
48centriole assembly (GO:0098534)3.03163631
49axon ensheathment (GO:0008366)3.02878480
50ensheathment of neurons (GO:0007272)3.02878480
51regulation of centriole replication (GO:0046599)3.02433172
52lymphangiogenesis (GO:0001946)3.02380279
53mesodermal cell differentiation (GO:0048333)3.02349639
54mesenchymal cell proliferation (GO:0010463)3.02125954
55myelination (GO:0042552)3.00562228
56attachment of spindle microtubules to kinetochore (GO:0008608)2.98441257
57interleukin-6-mediated signaling pathway (GO:0070102)2.96828555
58DNA double-strand break processing (GO:0000729)2.96484263
59regulation of DNA endoreduplication (GO:0032875)2.96340566
60platelet-derived growth factor receptor signaling pathway (GO:0048008)2.95742993
61regulation of transforming growth factor beta2 production (GO:0032909)2.95226662
62photoreceptor cell maintenance (GO:0045494)2.95096862
63reproduction (GO:0000003)2.92383606
64nucleotide-excision repair, DNA gap filling (GO:0006297)2.91393561
65regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.91111154
66kinetochore assembly (GO:0051382)2.90465695
67fibroblast migration (GO:0010761)2.90172294
68motile cilium assembly (GO:0044458)2.87974926
69regulation of cilium movement (GO:0003352)2.87832452
70mitotic recombination (GO:0006312)2.86842934
71regulation of centrosome cycle (GO:0046605)2.86765475
72enteric nervous system development (GO:0048484)2.86693487
73negative regulation of neurotransmitter transport (GO:0051589)2.86324506
74chondrocyte proliferation (GO:0035988)2.85294048
75regulation of meiosis I (GO:0060631)2.84867867
76lung-associated mesenchyme development (GO:0060484)2.83703252
77retina vasculature morphogenesis in camera-type eye (GO:0061299)2.83400375
78* cilium organization (GO:0044782)2.81076350
79meiotic cell cycle (GO:0051321)2.80710728
80radial glial cell differentiation (GO:0060019)2.79918824
81maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.78735579
82Leydig cell differentiation (GO:0033327)2.77199499
83retinal cone cell development (GO:0046549)2.76465465
84telomere maintenance via recombination (GO:0000722)2.76165621
85face morphogenesis (GO:0060325)2.76058660
86translesion synthesis (GO:0019985)2.75506675
87microtubule depolymerization (GO:0007019)2.74659250
88regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.74151836
89* cilium assembly (GO:0042384)2.73437900
90somite development (GO:0061053)2.71859058
91cell surface receptor signaling pathway involved in heart development (GO:0061311)2.71366234
92mitotic G2/M transition checkpoint (GO:0044818)2.70805486
93organelle disassembly (GO:1903008)2.70442653
94regulation of SMAD protein import into nucleus (GO:0060390)2.69948044
95DNA damage response, detection of DNA damage (GO:0042769)2.68888599
96regulation of spindle organization (GO:0090224)2.67247292
97protein-cofactor linkage (GO:0018065)2.66565760
98mitotic chromosome condensation (GO:0007076)2.66358835
99establishment of chromosome localization (GO:0051303)2.66210120
100positive regulation of histone H3-K4 methylation (GO:0051571)2.66066926
101proteasome assembly (GO:0043248)2.65938818
102magnesium ion transport (GO:0015693)2.65084234
103DNA strand elongation involved in DNA replication (GO:0006271)2.64395017
104keratinocyte development (GO:0003334)2.64333922
105DNA replication-dependent nucleosome assembly (GO:0006335)2.63936491
106DNA replication-dependent nucleosome organization (GO:0034723)2.63936491
107sister chromatid segregation (GO:0000819)2.63266884
108glomerular visceral epithelial cell development (GO:0072015)2.63039513
109positive regulation of hormone biosynthetic process (GO:0046886)2.62898903
110protein localization to cell surface (GO:0034394)2.62122868
111regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.62052113
112glomerular epithelial cell development (GO:0072310)2.62011620
113mitotic sister chromatid cohesion (GO:0007064)2.61865599
114spindle checkpoint (GO:0031577)2.61417915
115mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.60671937
116hippo signaling (GO:0035329)2.59424948
117sperm-egg recognition (GO:0035036)2.59003474
118centrosome organization (GO:0051297)2.58620641
119DNA strand elongation (GO:0022616)2.58089227
120mitotic cell cycle arrest (GO:0071850)2.57930561
121negative regulation of catenin import into nucleus (GO:0035414)2.57050202
122vascular endothelial growth factor signaling pathway (GO:0038084)2.56250406
123protein K11-linked ubiquitination (GO:0070979)2.55870037
124postreplication repair (GO:0006301)2.55865722
125DNA methylation involved in gamete generation (GO:0043046)2.55615116
126neuron fate determination (GO:0048664)2.55118485
127DNA catabolic process, exonucleolytic (GO:0000738)2.55016504
128sperm motility (GO:0030317)2.54295076
129plasma membrane fusion (GO:0045026)2.53534755
130mitotic sister chromatid segregation (GO:0000070)2.53310718
131recombinational repair (GO:0000725)2.53079082
132mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.52308672
133long-chain fatty acid biosynthetic process (GO:0042759)2.52072050
134cell fate commitment involved in formation of primary germ layer (GO:0060795)2.51838279
135double-strand break repair via homologous recombination (GO:0000724)2.51621989
136negative regulation of DNA-dependent DNA replication (GO:2000104)2.51513290
137neural tube formation (GO:0001841)2.50803013
138cytoplasmic mRNA processing body assembly (GO:0033962)2.49004693
139protein localization to chromosome (GO:0034502)2.48735439
140skin morphogenesis (GO:0043589)2.48137928
141cilium morphogenesis (GO:0060271)2.47551921
142oligodendrocyte differentiation (GO:0048709)2.47260732
143establishment of protein localization to mitochondrial membrane (GO:0090151)2.46926256
144negative regulation of stem cell proliferation (GO:2000647)2.46926096
145regulation of RNA export from nucleus (GO:0046831)2.46437651
146genitalia morphogenesis (GO:0035112)2.46150897
147branch elongation of an epithelium (GO:0060602)2.46121545
148regulation of mitotic metaphase/anaphase transition (GO:0030071)2.45352606
149regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.45352606
150platelet dense granule organization (GO:0060155)2.45311139
151asymmetric protein localization (GO:0008105)2.45137062
152mitochondrial respiratory chain complex I assembly (GO:0032981)2.44665998
153NADH dehydrogenase complex assembly (GO:0010257)2.44665998
154mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.44665998
155anatomical structure arrangement (GO:0048532)2.44153853
156cerebral cortex radially oriented cell migration (GO:0021799)2.43910552
157positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.43691972
158regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.43691972
159digestive tract morphogenesis (GO:0048546)2.43425845
160embryonic body morphogenesis (GO:0010172)2.43339222
161regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.43229137
162regulation of cell proliferation involved in kidney development (GO:1901722)2.42254766
163axis elongation (GO:0003401)2.42245831
164microtubule organizing center organization (GO:0031023)2.42106443
165chromosome segregation (GO:0007059)2.40579589
166fatty acid elongation (GO:0030497)2.40492250
167protein localization to cilium (GO:0061512)2.39939502
168negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.39887451
169negative regulation of mitotic sister chromatid segregation (GO:0033048)2.39887451
170negative regulation of mitotic sister chromatid separation (GO:2000816)2.39887451
171negative regulation of sister chromatid segregation (GO:0033046)2.39887451
172negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.39887451
173embryonic cranial skeleton morphogenesis (GO:0048701)2.38675846
174regulation of mitotic sister chromatid segregation (GO:0033047)2.38470540
175regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.36498663
176positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.36498663
177microtubule severing (GO:0051013)2.36426260
178branching involved in salivary gland morphogenesis (GO:0060445)2.36304039
179retinal rod cell development (GO:0046548)2.36106654
180virion attachment to host cell (GO:0019062)2.34903819
181adhesion of symbiont to host cell (GO:0044650)2.34903819
182cardiac epithelial to mesenchymal transition (GO:0060317)2.34754963
183regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.34727782
184myelination in peripheral nervous system (GO:0022011)2.31435706
185peripheral nervous system axon ensheathment (GO:0032292)2.31435706
186keratinocyte differentiation (GO:0030216)2.31143381
187binding of sperm to zona pellucida (GO:0007339)2.30068371
188apical protein localization (GO:0045176)2.28415473
189* nonmotile primary cilium assembly (GO:0035058)2.28233297
190growth hormone receptor signaling pathway (GO:0060396)2.27733105
191regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.27111124

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.71316987
2E2F7_22180533_ChIP-Seq_HELA_Human3.60112582
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.58833706
4EZH2_22144423_ChIP-Seq_EOC_Human3.46970271
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.42864827
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.20670276
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.00239953
8WT1_19549856_ChIP-ChIP_CCG9911_Human2.91237156
9ELK1_19687146_ChIP-ChIP_HELA_Human2.87981753
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.81303175
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.58170146
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.57558717
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.56608812
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.50842786
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.46457500
16ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.43698060
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.40807710
18* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35637243
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34981201
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.16986698
21ZNF274_21170338_ChIP-Seq_K562_Hela2.14705414
22AR_21572438_ChIP-Seq_LNCaP_Human2.09511071
23TAF15_26573619_Chip-Seq_HEK293_Human2.07073779
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.05546786
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05249747
26ZNF217_24962896_ChIP-Seq_MCF-7_Human2.00628236
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98811833
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.97391648
29CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.94908841
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.93763914
31IGF1R_20145208_ChIP-Seq_DFB_Human1.93282122
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91308418
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87082962
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84800992
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.82095760
36AR_21909140_ChIP-Seq_LNCAP_Human1.80370325
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.76655314
38* CJUN_26792858_Chip-Seq_BT549_Human1.76505291
39SOX9_24532713_ChIP-Seq_HFSC_Mouse1.75274450
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74069886
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.71204043
42P300_19829295_ChIP-Seq_ESCs_Human1.70180992
43VDR_23849224_ChIP-Seq_CD4+_Human1.68478831
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67414342
45MYC_18555785_ChIP-Seq_MESCs_Mouse1.67328077
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66465866
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.63420150
48MYC_18940864_ChIP-ChIP_HL60_Human1.60282324
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55328122
50KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.52334611
51KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.52334611
52KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.52334611
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52016581
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51495034
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.50558955
56TP53_16413492_ChIP-PET_HCT116_Human1.50300237
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.50279074
58FUS_26573619_Chip-Seq_HEK293_Human1.47879046
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45504536
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45146303
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43664648
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.42421647
63SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.40020867
64SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.40020867
65EP300_21415370_ChIP-Seq_HL-1_Mouse1.39232227
66IRF1_19129219_ChIP-ChIP_H3396_Human1.37910325
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.36925396
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.36802282
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.35868613
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34571117
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32915702
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32885378
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32829610
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31238935
75CBP_20019798_ChIP-Seq_JUKART_Human1.30334473
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30334473
77STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.30047541
78GBX2_23144817_ChIP-Seq_PC3_Human1.29718119
79BRD4_25478319_ChIP-Seq_HGPS_Human1.29238695
80TP53_18474530_ChIP-ChIP_U2OS_Human1.28154123
81AHR_22903824_ChIP-Seq_MCF-7_Human1.27956566
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27857342
83TTF2_22483619_ChIP-Seq_HELA_Human1.27782441
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.26772659
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26629726
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25704789
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24640707
88FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24231755
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23753909
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23569787
91FOXP3_21729870_ChIP-Seq_TREG_Human1.22979618
92DCP1A_22483619_ChIP-Seq_HELA_Human1.22560955
93ER_23166858_ChIP-Seq_MCF-7_Human1.22158939
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21751729
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21287889
96NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21287889
97UBF1/2_26484160_Chip-Seq_HMECs_Human1.19598768
98JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19509238
99CLOCK_20551151_ChIP-Seq_293T_Human1.19389821
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17973701
101PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17678993
102SMAD4_21799915_ChIP-Seq_A2780_Human1.15842973
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15718035
104MYC_19030024_ChIP-ChIP_MESCs_Mouse1.14674270
105E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14604997
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13672660
107SMAD3_21741376_ChIP-Seq_EPCs_Human1.13657841
108VDR_22108803_ChIP-Seq_LS180_Human1.12875553
109ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10429066
110TCF4_18268006_ChIP-ChIP_LS174T_Human1.09472888
111RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08416811
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08107702
113MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04991361
114GABP_19822575_ChIP-Seq_HepG2_Human1.04979761
115SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04498291
116ARNT_22903824_ChIP-Seq_MCF-7_Human1.04077708
117TP63_23658742_ChIP-Seq_EP156T_Human1.03862729
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03407255
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02898671
120FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02782154
121POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02754063
122TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02418481
123BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01810679
124CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01132461
125* STAT3_23295773_ChIP-Seq_U87_Human1.01110934
126HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00852199
127TP53_22573176_ChIP-Seq_HFKS_Human1.00841336
128PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00672368
129EWS_26573619_Chip-Seq_HEK293_Human1.00579642
130E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00287835
131SMAD_19615063_ChIP-ChIP_OVARY_Human1.00255124
132* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00230219
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.99339262
134NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99125014
135NANOG_18555785_Chip-Seq_ESCs_Mouse0.97960839
136FLI1_27457419_Chip-Seq_LIVER_Mouse0.97828616
137SRF_21415370_ChIP-Seq_HL-1_Mouse0.97265422
138PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96805335
139AR_25329375_ChIP-Seq_VCAP_Human0.96783667
140TCF4_22108803_ChIP-Seq_LS180_Human0.96690201
141EZH2_27294783_Chip-Seq_NPCs_Mouse0.96320226
142RING1B_27294783_Chip-Seq_NPCs_Mouse0.96209363
143MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96147028
144* GATA2_21666600_ChIP-Seq_HMVEC_Human0.95596584
145NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95384205
146KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95351152
147SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95046422
148POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94980118
149SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94699058
150KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94665036
151JUN_21703547_ChIP-Seq_K562_Human0.94143815
152ISL1_27105846_Chip-Seq_CPCs_Mouse0.94132590
153CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93634278
154NANOG_19829295_ChIP-Seq_ESCs_Human0.92910047
155SOX2_19829295_ChIP-Seq_ESCs_Human0.92910047
156KLF5_25053715_ChIP-Seq_YYC3_Human0.92628602
157TBL1_22424771_ChIP-Seq_293T_Human0.92272158
158FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90899092
159SMAD4_21741376_ChIP-Seq_EPCs_Human0.90364520
160SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.90250816
161EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90202495
162RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90156197
163RNF2_27304074_Chip-Seq_NSC_Mouse0.89873292
164TCF3_18692474_ChIP-Seq_MESCs_Mouse0.89731401
165JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89646903
166RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88879371
167VDR_24787735_ChIP-Seq_THP-1_Human0.88184079
168* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86823914
169CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86524672
170BCAT_22108803_ChIP-Seq_LS180_Human0.86052202
171* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.85557533

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development3.99137560
2MP0006292_abnormal_olfactory_placode3.72178373
3MP0003950_abnormal_plasma_membrane3.62428633
4MP0008438_abnormal_cutaneous_collagen3.10779372
5MP0008789_abnormal_olfactory_epithelium2.91610544
6MP0003718_maternal_effect2.86365603
7MP0010678_abnormal_skin_adnexa2.64909118
8MP0010094_abnormal_chromosome_stability2.54036542
9MP0000383_abnormal_hair_follicle2.51375545
10MP0005275_abnormal_skin_tensile2.49672326
11MP0002234_abnormal_pharynx_morphology2.47615864
12MP0008058_abnormal_DNA_repair2.42607761
13MP0003693_abnormal_embryo_hatching2.38787441
14MP0000569_abnormal_digit_pigmentation2.37194707
15MP0008877_abnormal_DNA_methylation2.34985792
16MP0001851_eye_inflammation2.27095004
17MP0005551_abnormal_eye_electrophysiolog2.24096511
18MP0003890_abnormal_embryonic-extraembry2.21611325
19MP0005394_taste/olfaction_phenotype2.18566474
20MP0005499_abnormal_olfactory_system2.18566474
21MP0010030_abnormal_orbit_morphology2.16028144
22MP0004272_abnormal_basement_membrane2.01443157
23MP0008057_abnormal_DNA_replication1.98163545
24MP0002060_abnormal_skin_morphology1.97797654
25MP0005171_absent_coat_pigmentation1.92805176
26MP0005503_abnormal_tendon_morphology1.91867533
27MP0010234_abnormal_vibrissa_follicle1.90970934
28MP0001529_abnormal_vocalization1.90820211
29MP0003705_abnormal_hypodermis_morpholog1.89944323
30MP0003880_abnormal_central_pattern1.86847466
31MP0003385_abnormal_body_wall1.84050183
32MP0009384_cardiac_valve_regurgitation1.82845955
33MP0010352_gastrointestinal_tract_polyps1.79686103
34MP0003121_genomic_imprinting1.79590095
35MP0001958_emphysema1.76961530
36MP0002102_abnormal_ear_morphology1.76427603
37MP0006072_abnormal_retinal_apoptosis1.75727348
38MP0000647_abnormal_sebaceous_gland1.75469225
39MP0002254_reproductive_system_inflammat1.74973259
40MP0009250_abnormal_appendicular_skeleto1.73916334
41MP0002796_impaired_skin_barrier1.73723816
42MP0004381_abnormal_hair_follicle1.73496087
43MP0003937_abnormal_limbs/digits/tail_de1.72920951
44MP0005623_abnormal_meninges_morphology1.67908958
45MP0003136_yellow_coat_color1.67808758
46MP0000762_abnormal_tongue_morphology1.66117287
47MP0003077_abnormal_cell_cycle1.64211197
48MP0002098_abnormal_vibrissa_morphology1.62919433
49MP0008932_abnormal_embryonic_tissue1.60027640
50MP0003453_abnormal_keratinocyte_physiol1.58809608
51MP0000372_irregular_coat_pigmentation1.56876606
52MP0004133_heterotaxia1.56467536
53MP0000566_synostosis1.56343736
54MP0001216_abnormal_epidermal_layer1.54887865
55MP0005508_abnormal_skeleton_morphology1.52817921
56MP0000467_abnormal_esophagus_morphology1.51932662
57MP0003755_abnormal_palate_morphology1.51231019
58MP0004957_abnormal_blastocyst_morpholog1.50911790
59MP0003566_abnormal_cell_adhesion1.50746729
60MP0000377_abnormal_hair_follicle1.49581807
61MP0005410_abnormal_fertilization1.49348229
62MP0000049_abnormal_middle_ear1.48890233
63MP0000778_abnormal_nervous_system1.46176617
64MP0000733_abnormal_muscle_development1.45568847
65MP0002877_abnormal_melanocyte_morpholog1.44970578
66MP0003787_abnormal_imprinting1.43669818
67MP0000465_gastrointestinal_hemorrhage1.43603962
68MP0009697_abnormal_copulation1.42896018
69MP0002938_white_spotting1.42674664
70MP0003111_abnormal_nucleus_morphology1.42643388
71MP0002009_preneoplasia1.42448023
72MP0005023_abnormal_wound_healing1.40559602
73MP0009379_abnormal_foot_pigmentation1.39368851
74MP0001984_abnormal_olfaction1.38352139
75MP0003091_abnormal_cell_migration1.37849106
76MP0005195_abnormal_posterior_eye1.37842181
77MP0003011_delayed_dark_adaptation1.35908928
78MP0002160_abnormal_reproductive_system1.31706071
79MP0010368_abnormal_lymphatic_system1.31510091
80MP0002282_abnormal_trachea_morphology1.31310154
81MP0003119_abnormal_digestive_system1.31242972
82MP0002210_abnormal_sex_determination1.30227501
83MP0005187_abnormal_penis_morphology1.30011228
84MP0002095_abnormal_skin_pigmentation1.29545733
85MP0000427_abnormal_hair_cycle1.29117241
86MP0000432_abnormal_head_morphology1.28896534
87MP0005076_abnormal_cell_differentiation1.28783908
88MP0005084_abnormal_gallbladder_morpholo1.28573087
89MP0000631_abnormal_neuroendocrine_gland1.27142045
90MP0002295_abnormal_pulmonary_circulatio1.26502297
91MP0001340_abnormal_eyelid_morphology1.25538001
92MP0000428_abnormal_craniofacial_morphol1.24760030
93MP0005174_abnormal_tail_pigmentation1.22015707
94MP0005253_abnormal_eye_physiology1.18175729
95MP0002653_abnormal_ependyma_morphology1.17820406
96MP0001346_abnormal_lacrimal_gland1.16434870
97MP0000920_abnormal_myelination1.16002932
98MP0005501_abnormal_skin_physiology1.14816207
99MP0000579_abnormal_nail_morphology1.14223116
100MP0001929_abnormal_gametogenesis1.13812287
101MP0006276_abnormal_autonomic_nervous1.13648774
102MP0002233_abnormal_nose_morphology1.13007467
103MP0008007_abnormal_cellular_replicative1.12559117
104MP0005391_vision/eye_phenotype1.11309776
105MP0001324_abnormal_eye_pigmentation1.10835905
106MP0010771_integument_phenotype1.09571478
107MP0003300_gastrointestinal_ulcer1.09398108
108MP0006054_spinal_hemorrhage1.08789961
109MP0001299_abnormal_eye_distance/1.08630039
110MP0003935_abnormal_craniofacial_develop1.08504021
111MP0002111_abnormal_tail_morphology1.08436222
112MP0000653_abnormal_sex_gland1.08200884
113MP0005395_other_phenotype1.07646671
114MP0005257_abnormal_intraocular_pressure1.07214063
115MP0004185_abnormal_adipocyte_glucose1.06199132
116MP0000516_abnormal_urinary_system1.05233000
117MP0005367_renal/urinary_system_phenotyp1.05233000
118MP0009278_abnormal_bone_marrow1.03535344
119MP0002092_abnormal_eye_morphology1.02484358
120MP0001879_abnormal_lymphatic_vessel1.01462743
121MP0000767_abnormal_smooth_muscle1.01395726
122MP0001286_abnormal_eye_development0.99990252
123MP0000534_abnormal_ureter_morphology0.98932353
124MP0001145_abnormal_male_reproductive0.97506746
125MP0004142_abnormal_muscle_tone0.96072124
126MP0002697_abnormal_eye_size0.95655205
127MP0001293_anophthalmia0.94284962
128MP0002133_abnormal_respiratory_system0.93691030
129MP0005388_respiratory_system_phenotype0.93691030
130MP0003828_pulmonary_edema0.91725356
131MP0005389_reproductive_system_phenotype0.91704527
132MP0001849_ear_inflammation0.91381816
133MP0000462_abnormal_digestive_system0.91358188
134MP0003786_premature_aging0.91121602
135MP0001697_abnormal_embryo_size0.89357171
136MP0002896_abnormal_bone_mineralization0.87890337
137* MP0003861_abnormal_nervous_system0.87697598
138MP0003938_abnormal_ear_development0.87253050
139MP0005408_hypopigmentation0.87067704
140MP0005646_abnormal_pituitary_gland0.86831385
141MP0002752_abnormal_somatic_nervous0.86801166
142* MP0002085_abnormal_embryonic_tissue0.86424713
143MP0002109_abnormal_limb_morphology0.86127776
144MP0003942_abnormal_urinary_system0.86042159
145MP0002932_abnormal_joint_morphology0.85883190
146MP0003186_abnormal_redox_activity0.85725136
147MP0002116_abnormal_craniofacial_bone0.85656039
148MP0002928_abnormal_bile_duct0.84558389
149* MP0002084_abnormal_developmental_patter0.84355139
150MP0001270_distended_abdomen0.82565268
151MP0005248_abnormal_Harderian_gland0.81883732
152MP0003698_abnormal_male_reproductive0.81870411
153MP0002090_abnormal_vision0.81483524
154MP0002925_abnormal_cardiovascular_devel0.81336205
155MP0003936_abnormal_reproductive_system0.81252746
156MP0002638_abnormal_pupillary_reflex0.80081679
157MP0002177_abnormal_outer_ear0.78923546
158MP0001243_abnormal_dermal_layer0.78899954
159MP0001119_abnormal_female_reproductive0.77862057
160MP0002751_abnormal_autonomic_nervous0.75915560
161MP0000613_abnormal_salivary_gland0.75714675
162MP0005377_hearing/vestibular/ear_phenot0.75079235
163MP0003878_abnormal_ear_physiology0.75079235
164MP0005083_abnormal_biliary_tract0.73435133
165MP0002184_abnormal_innervation0.71212376

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.48037436
2Absent/shortened dynein arms (HP:0200106)4.51200236
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.51200236
4Abnormal respiratory motile cilium physiology (HP:0012261)4.41116906
5Abnormal ciliary motility (HP:0012262)3.81692571
6Bony spicule pigmentary retinopathy (HP:0007737)3.78674453
7True hermaphroditism (HP:0010459)3.51870148
8Premature rupture of membranes (HP:0001788)3.46773736
9Rhinitis (HP:0012384)3.45758937
10Abnormal respiratory epithelium morphology (HP:0012253)3.41245496
11Abnormal respiratory motile cilium morphology (HP:0005938)3.41245496
12Pancreatic cysts (HP:0001737)3.36851668
13Degeneration of the lateral corticospinal tracts (HP:0002314)3.06964999
14Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.06964999
15Congenital stationary night blindness (HP:0007642)3.00355795
16Chorioretinal atrophy (HP:0000533)2.98564029
17Lip pit (HP:0100267)2.88207334
18Congenital primary aphakia (HP:0007707)2.85596779
19Volvulus (HP:0002580)2.76645251
20Natal tooth (HP:0000695)2.70837642
21Gait imbalance (HP:0002141)2.68409272
22Colon cancer (HP:0003003)2.66488217
23Chronic bronchitis (HP:0004469)2.59176520
24Nephrogenic diabetes insipidus (HP:0009806)2.54448498
25Acute necrotizing encephalopathy (HP:0006965)2.53864418
26Aplasia cutis congenita (HP:0001057)2.53820859
27Aplasia/Hypoplasia of the sacrum (HP:0008517)2.53082856
28Concave nail (HP:0001598)2.49807923
29Persistence of primary teeth (HP:0006335)2.47915903
30Oligodactyly (hands) (HP:0001180)2.46871322
31Chromsome breakage (HP:0040012)2.43766377
32Sclerocornea (HP:0000647)2.42862740
33Preaxial hand polydactyly (HP:0001177)2.41298060
34Postaxial hand polydactyly (HP:0001162)2.40104603
35Aplasia/Hypoplasia of the tibia (HP:0005772)2.36630125
36Short tibia (HP:0005736)2.36444522
37Hypoplastic pelvis (HP:0008839)2.35590779
38Atrophic scars (HP:0001075)2.35359304
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.34685698
40Supernumerary spleens (HP:0009799)2.31782853
41Abnormality of macular pigmentation (HP:0008002)2.28592248
42Tubular atrophy (HP:0000092)2.25384079
43Abnormality of the renal cortex (HP:0011035)2.25205422
44Shallow orbits (HP:0000586)2.22942840
45Cystic liver disease (HP:0006706)2.22009154
46Abnormality of chromosome stability (HP:0003220)2.21221959
47Abnormality of the labia minora (HP:0012880)2.18741205
48Milia (HP:0001056)2.17358986
49Abnormal lung lobation (HP:0002101)2.16519109
50Mitochondrial inheritance (HP:0001427)2.16424953
51Coronal craniosynostosis (HP:0004440)2.16004386
52Progressive macrocephaly (HP:0004481)2.15341565
53Bell-shaped thorax (HP:0001591)2.14839927
54Abnormality of the corticospinal tract (HP:0002492)2.13693562
55Abnormal mitochondria in muscle tissue (HP:0008316)2.13687529
56Termporal pattern (HP:0011008)2.13611660
57Insidious onset (HP:0003587)2.13611660
58Parakeratosis (HP:0001036)2.12639747
59Chromosomal breakage induced by crosslinking agents (HP:0003221)2.10395951
60Protrusio acetabuli (HP:0003179)2.07644948
61Increased corneal curvature (HP:0100692)2.05955151
62Keratoconus (HP:0000563)2.05955151
63Bifid tongue (HP:0010297)2.05879092
64Acute encephalopathy (HP:0006846)2.04826296
65Abnormality of dentin (HP:0010299)2.04464336
66Abnormal rod and cone electroretinograms (HP:0008323)2.03368744
67Poor coordination (HP:0002370)2.02852434
68Oligodactyly (HP:0012165)2.02724483
69Microglossia (HP:0000171)2.02070838
70Impulsivity (HP:0100710)2.01412383
71Central scotoma (HP:0000603)2.00832706
72Increased CSF lactate (HP:0002490)2.00707382
73Meckel diverticulum (HP:0002245)1.99106293
74Absent septum pellucidum (HP:0001331)1.98436514
75Attenuation of retinal blood vessels (HP:0007843)1.97746788
76Anteriorly placed anus (HP:0001545)1.97220466
77Soft skin (HP:0000977)1.94950001
78Rib fusion (HP:0000902)1.94895324
79Hypodontia (HP:0000668)1.94357739
80Bronchiectasis (HP:0002110)1.92177754
81Aplasia involving bones of the extremities (HP:0009825)1.91911793
82Aplasia involving bones of the upper limbs (HP:0009823)1.91911793
83Aplasia of the phalanges of the hand (HP:0009802)1.91911793
84Fragile skin (HP:0001030)1.91517788
85Congenital hepatic fibrosis (HP:0002612)1.90531805
86Broad metatarsal (HP:0001783)1.89896288
87Abnormal hemoglobin (HP:0011902)1.89708422
88Asymmetry of the thorax (HP:0001555)1.88153170
89Chin dimple (HP:0010751)1.86616930
90Sloping forehead (HP:0000340)1.86188917
91Abnormality of the ileum (HP:0001549)1.85902198
92Scotoma (HP:0000575)1.84586553
93Increased hepatocellular lipid droplets (HP:0006565)1.84021882
94Reticulocytopenia (HP:0001896)1.83878136
95Pigmentary retinal degeneration (HP:0001146)1.83725818
96Abnormality of abdominal situs (HP:0011620)1.83682983
97Abdominal situs inversus (HP:0003363)1.83682983
98Esophageal atresia (HP:0002032)1.83403847
99Peritonitis (HP:0002586)1.82790019
100Anterior segment dysgenesis (HP:0007700)1.82212185
101Triphalangeal thumb (HP:0001199)1.81572031
102* Aganglionic megacolon (HP:0002251)1.80466525
103Septo-optic dysplasia (HP:0100842)1.78573073
104Astigmatism (HP:0000483)1.78239174
105Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77399734
106Chronic hepatic failure (HP:0100626)1.77389770
107Small hand (HP:0200055)1.76515189
108Pancreatic fibrosis (HP:0100732)1.76433838
109Renal cortical cysts (HP:0000803)1.75810093
110Hepatocellular necrosis (HP:0001404)1.75265938
111Advanced eruption of teeth (HP:0006288)1.74462991
112Dandy-Walker malformation (HP:0001305)1.74149243
113Bladder diverticulum (HP:0000015)1.74014929
114Abnormality of molar morphology (HP:0011070)1.73286240
115Abnormality of molar (HP:0011077)1.73286240
116Hepatic necrosis (HP:0002605)1.73203684
117Multicystic kidney dysplasia (HP:0000003)1.73146113
118Male pseudohermaphroditism (HP:0000037)1.72632367
119Ectopic kidney (HP:0000086)1.72244169
120Spinal rigidity (HP:0003306)1.72014595
121Short nail (HP:0001799)1.71911955
122Tubulointerstitial nephritis (HP:0001970)1.71567890
123Hypoplastic female external genitalia (HP:0012815)1.70826330
124Holoprosencephaly (HP:0001360)1.69743955
125Abnormality of the septum pellucidum (HP:0007375)1.69227358
126Abnormality of the preputium (HP:0100587)1.69040042
127Facial hemangioma (HP:0000329)1.68808722
128Cortical dysplasia (HP:0002539)1.67722094
129Congenital, generalized hypertrichosis (HP:0004540)1.67720395
130Hypoplasia of the iris (HP:0007676)1.67546807
131Abnormality of the anterior chamber (HP:0000593)1.67173211
132Follicular hyperkeratosis (HP:0007502)1.66811952
133Cerebral edema (HP:0002181)1.66617276
134Renal Fanconi syndrome (HP:0001994)1.66609100
135Abnormality of the nasolacrimal system (HP:0000614)1.65915083
136Genital tract atresia (HP:0001827)1.65553759
137* Narrow forehead (HP:0000341)1.65145227
138Abnormal number of incisors (HP:0011064)1.64988896
139Aplasia/Hypoplasia of the tongue (HP:0010295)1.64814256
140Ankle contracture (HP:0006466)1.64571235
141Pendular nystagmus (HP:0012043)1.64147730
142Taurodontia (HP:0000679)1.63683915
143Abnormality of permanent molar morphology (HP:0011071)1.63683915
144Abnormality of the dental root (HP:0006486)1.63683915
145Fibular hypoplasia (HP:0003038)1.63508520
146* Prominent nasal bridge (HP:0000426)1.62883104
1473-Methylglutaconic aciduria (HP:0003535)1.62720085
148Anophthalmia (HP:0000528)1.62687941
149Hypoplastic labia majora (HP:0000059)1.62620103
150Retinal dysplasia (HP:0007973)1.61692016
151Delayed cranial suture closure (HP:0000270)1.61595865
152Nephronophthisis (HP:0000090)1.60439805
153Aqueductal stenosis (HP:0002410)1.60430560
154Vaginal atresia (HP:0000148)1.59651068
155Medial flaring of the eyebrow (HP:0010747)1.58649128
156Abolished electroretinogram (ERG) (HP:0000550)1.56567710
157Nasolacrimal duct obstruction (HP:0000579)1.56324118
158Intellectual disability, moderate (HP:0002342)1.54328175
159Cone-rod dystrophy (HP:0000548)1.54193133
160Occipital encephalocele (HP:0002085)1.54137415
161Median cleft lip (HP:0000161)1.53016099
162Femoral bowing (HP:0002980)1.52434847
163Abnormality of the renal medulla (HP:0100957)1.52346244
164Wormian bones (HP:0002645)1.51914306
165* Molar tooth sign on MRI (HP:0002419)1.51553965
166* Abnormality of midbrain morphology (HP:0002418)1.51553965
167Adrenal hypoplasia (HP:0000835)1.50825458
168Postaxial foot polydactyly (HP:0001830)1.49987075
169Acute myeloid leukemia (HP:0004808)1.49623252
170Venous abnormality (HP:0002624)1.49162521
171Anencephaly (HP:0002323)1.48311680

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK153.70486847
2CDC73.48604300
3EPHB13.43366571
4TNIK2.99144917
5EPHA32.89119418
6DDR22.65745828
7LATS12.53601402
8WNK32.38132157
9STK392.34998580
10WEE12.30635606
11PBK2.27089101
12EIF2AK12.10194764
13EIF2AK32.07797394
14CDK122.03852232
15NUAK11.99436427
16TRIM281.97911649
17BUB11.95227836
18GRK11.94288973
19MAP4K21.93679414
20MAP3K41.91135675
21TAOK21.88624761
22FRK1.83075025
23STK101.78596543
24SRPK11.76909410
25BRSK21.74970699
26IRAK11.73914239
27MAP3K21.72013828
28CASK1.71734367
29NEK11.71357485
30BCR1.68676525
31PDGFRA1.65370117
32MAPKAPK51.62597135
33TESK21.62508176
34WNK11.61084204
35MAP3K31.53436151
36PLK11.51669567
37PNCK1.51108720
38DMPK1.50511768
39FGFR21.48949402
40MKNK21.45928595
41FER1.42171098
42EPHB21.39752858
43BRD41.39046883
44BMPR1B1.34252914
45MET1.31001588
46MAP2K71.30767123
47PKN11.29506103
48DYRK1B1.28541778
49TRPM71.25324239
50PDGFRB1.22735629
51VRK21.22313288
52CDK81.19800379
53PLK21.15428625
54AURKB1.15372150
55NEK21.10459579
56ZAK1.07581022
57TSSK61.07288964
58TGFBR11.06591875
59LIMK11.05883450
60MST41.05185413
61TGFBR21.04692237
62EEF2K1.03517542
63STK31.03151962
64MOS1.00022924
65STK38L0.99974511
66LRRK20.99086404
67TAF10.99048761
68HIPK20.98874186
69STK160.96406231
70PAK20.95741166
71PDK20.95481352
72IRAK20.93794314
73EPHA40.93492571
74CCNB10.92963901
75ATR0.91957223
76MARK20.91246418
77PAK30.89872317
78CDK60.88831483
79BRSK10.88060771
80TLK10.87133992
81BRAF0.85214350
82AURKA0.85090272
83TYRO30.83316995
84BCKDK0.83083644
85RPS6KA50.81748821
86NLK0.81131336
87FGFR40.81012787
88ROCK20.80306599
89OXSR10.80061683
90MTOR0.79918290
91MAP3K90.79744363
92EPHA20.79240259
93AKT30.78575032
94ERBB30.78207444
95GSK3A0.76977344
96TESK10.76730537
97NEK60.76584085
98WNK40.75108138
99ATM0.74758732
100CHEK10.73090988
101MAP3K120.72601740
102CSNK1G20.72465501
103ERBB40.72289054
104CAMK1G0.72020199
105VRK10.71378580
106ARAF0.70108763
107CSNK1D0.68466942
108MKNK10.68275597
109CSNK1G30.68204961
110MAPK130.67482003
111ALK0.67467161
112CSNK1A1L0.67282781
113PRKD10.66028579
114CDK70.64353938
115PLK40.63187554
116IKBKB0.62490691
117CSNK1E0.61199772
118CHEK20.60027590
119CDK90.60025681
120FGFR30.58838391
121CDK30.57949932
122TIE10.56486062
123KSR10.56026017
124PTK60.54864380
125MAP3K80.54166087
126PINK10.54072867
127INSRR0.53182200
128RPS6KA40.52867268
129MAP3K50.52566262
130TTK0.52405065
131PRKAA20.50990496
132PLK30.50807796
133PRKCQ0.50400667
134CSNK2A10.49765505
135ABL10.48741199
136TTN0.48401392
137EIF2AK20.48127716
138CSNK2A20.47111436
139PRKCI0.46531386
140CSNK1G10.46108442
141STK240.45667845
142CHUK0.45587908
143ADRBK20.45281214
144MAPKAPK20.44972791
145RET0.44554081
146TAOK30.44266807
147ACVR1B0.43071635
148FGFR10.42634911
149MAP2K20.42300614
150PRKCE0.41445753
151STK40.41307530
152MAPK70.41161430
153CDK10.40972945
154CLK10.39999917
155PRKD20.39706129
156DYRK20.39533422
157NTRK20.39469288
158INSR0.39336238
159IGF1R0.38336015
160ADRBK10.38288247
161DYRK30.37747605
162FGR0.37473406
163MINK10.36642295

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047445.01215764
2Mismatch repair_Homo sapiens_hsa034303.69013182
3Protein export_Homo sapiens_hsa030603.41273826
4Homologous recombination_Homo sapiens_hsa034403.13967900
5DNA replication_Homo sapiens_hsa030302.94131105
6Nucleotide excision repair_Homo sapiens_hsa034202.62589139
7Oxidative phosphorylation_Homo sapiens_hsa001902.52714458
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.42859384
9ECM-receptor interaction_Homo sapiens_hsa045122.35282902
10One carbon pool by folate_Homo sapiens_hsa006702.35134558
11Non-homologous end-joining_Homo sapiens_hsa034502.33878907
12Ribosome_Homo sapiens_hsa030102.30461942
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.27012901
14Proteasome_Homo sapiens_hsa030502.19974595
15RNA polymerase_Homo sapiens_hsa030202.02691285
16Parkinsons disease_Homo sapiens_hsa050122.02640355
17Huntingtons disease_Homo sapiens_hsa050162.02434922
18Base excision repair_Homo sapiens_hsa034101.89064958
19Cell cycle_Homo sapiens_hsa041101.88139633
20Hippo signaling pathway_Homo sapiens_hsa043901.84004026
21TGF-beta signaling pathway_Homo sapiens_hsa043501.82722408
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81521783
23RNA transport_Homo sapiens_hsa030131.81474754
24Sphingolipid metabolism_Homo sapiens_hsa006001.80903799
25Ovarian steroidogenesis_Homo sapiens_hsa049131.79389806
26Spliceosome_Homo sapiens_hsa030401.78165158
27MicroRNAs in cancer_Homo sapiens_hsa052061.77623755
28Linoleic acid metabolism_Homo sapiens_hsa005911.76983045
29Adherens junction_Homo sapiens_hsa045201.72808685
30Propanoate metabolism_Homo sapiens_hsa006401.72610146
31Basal cell carcinoma_Homo sapiens_hsa052171.72199985
32Dorso-ventral axis formation_Homo sapiens_hsa043201.65049167
33Axon guidance_Homo sapiens_hsa043601.60963678
34Prostate cancer_Homo sapiens_hsa052151.60231950
35Focal adhesion_Homo sapiens_hsa045101.59541446
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56459723
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56046789
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.49176450
39Renal cell carcinoma_Homo sapiens_hsa052111.45739022
40Tight junction_Homo sapiens_hsa045301.42604787
41Proteoglycans in cancer_Homo sapiens_hsa052051.42321829
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.40505291
43Ether lipid metabolism_Homo sapiens_hsa005651.38216399
44Small cell lung cancer_Homo sapiens_hsa052221.38020951
45Pyrimidine metabolism_Homo sapiens_hsa002401.32009335
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.30991949
47Hedgehog signaling pathway_Homo sapiens_hsa043401.29857502
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.28387669
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27731247
50Malaria_Homo sapiens_hsa051441.25618815
51PI3K-Akt signaling pathway_Homo sapiens_hsa041511.24491904
52Alzheimers disease_Homo sapiens_hsa050101.23357032
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21389309
54Folate biosynthesis_Homo sapiens_hsa007901.20526945
55Pyruvate metabolism_Homo sapiens_hsa006201.16919535
56TNF signaling pathway_Homo sapiens_hsa046681.16431315
57Wnt signaling pathway_Homo sapiens_hsa043101.16151064
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14226523
59Histidine metabolism_Homo sapiens_hsa003401.11125743
60Toxoplasmosis_Homo sapiens_hsa051451.10713641
61Tryptophan metabolism_Homo sapiens_hsa003801.10126297
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09789028
63Pathways in cancer_Homo sapiens_hsa052001.09558986
64Ras signaling pathway_Homo sapiens_hsa040141.09345529
65Rap1 signaling pathway_Homo sapiens_hsa040151.07128912
66MAPK signaling pathway_Homo sapiens_hsa040101.06746828
67RNA degradation_Homo sapiens_hsa030181.06047005
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04402596
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03234798
70Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02087361
71Lysine degradation_Homo sapiens_hsa003101.01569479
72Oocyte meiosis_Homo sapiens_hsa041140.98867275
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96996331
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96510336
75Amoebiasis_Homo sapiens_hsa051460.95434439
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.95217326
77HTLV-I infection_Homo sapiens_hsa051660.94976008
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94802007
79Cardiac muscle contraction_Homo sapiens_hsa042600.94549328
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94248461
81Bladder cancer_Homo sapiens_hsa052190.93788209
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93407964
83Purine metabolism_Homo sapiens_hsa002300.92472719
84Choline metabolism in cancer_Homo sapiens_hsa052310.91924320
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89620756
86Notch signaling pathway_Homo sapiens_hsa043300.89514365
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88622216
88GnRH signaling pathway_Homo sapiens_hsa049120.87927870
89Estrogen signaling pathway_Homo sapiens_hsa049150.87736053
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.85444752
91Melanoma_Homo sapiens_hsa052180.85194316
92p53 signaling pathway_Homo sapiens_hsa041150.84859982
93Fatty acid elongation_Homo sapiens_hsa000620.84181222
94Pancreatic cancer_Homo sapiens_hsa052120.83642224
95Osteoclast differentiation_Homo sapiens_hsa043800.83063070
96Butanoate metabolism_Homo sapiens_hsa006500.82262787
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81328766
98Viral carcinogenesis_Homo sapiens_hsa052030.79735518
99Mineral absorption_Homo sapiens_hsa049780.78992250
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78597250
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77309545
102Caffeine metabolism_Homo sapiens_hsa002320.76524260
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.76361094
104Circadian rhythm_Homo sapiens_hsa047100.75794708
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.75375181
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73379022
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72247112
108Peroxisome_Homo sapiens_hsa041460.70647461
109Dilated cardiomyopathy_Homo sapiens_hsa054140.68621152
110FoxO signaling pathway_Homo sapiens_hsa040680.67060579
111Chemical carcinogenesis_Homo sapiens_hsa052040.66500917
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66417687
113Metabolic pathways_Homo sapiens_hsa011000.65955592
114Steroid biosynthesis_Homo sapiens_hsa001000.65040091
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64606492
116Endocytosis_Homo sapiens_hsa041440.64024310
117T cell receptor signaling pathway_Homo sapiens_hsa046600.63864155
118B cell receptor signaling pathway_Homo sapiens_hsa046620.62136161
119Protein digestion and absorption_Homo sapiens_hsa049740.60840424
120Nitrogen metabolism_Homo sapiens_hsa009100.59975448
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.59972357
122Prolactin signaling pathway_Homo sapiens_hsa049170.58529803
123mRNA surveillance pathway_Homo sapiens_hsa030150.58486076
124VEGF signaling pathway_Homo sapiens_hsa043700.57238867
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57207075
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56077171
127beta-Alanine metabolism_Homo sapiens_hsa004100.55649941
128Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55537516
129Chronic myeloid leukemia_Homo sapiens_hsa052200.55165245
130Glutathione metabolism_Homo sapiens_hsa004800.54906146
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.54528939
132Cocaine addiction_Homo sapiens_hsa050300.54068508
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53546030
134Vitamin B6 metabolism_Homo sapiens_hsa007500.52745175
135Prion diseases_Homo sapiens_hsa050200.51934473
136Systemic lupus erythematosus_Homo sapiens_hsa053220.51143437
137Regulation of autophagy_Homo sapiens_hsa041400.50864554
138Melanogenesis_Homo sapiens_hsa049160.50275904
139Arachidonic acid metabolism_Homo sapiens_hsa005900.49634863
140Platelet activation_Homo sapiens_hsa046110.49483451
141Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48262508
142Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47808010
143Nicotine addiction_Homo sapiens_hsa050330.47701712
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.47562108
145Salmonella infection_Homo sapiens_hsa051320.47302541
146Adipocytokine signaling pathway_Homo sapiens_hsa049200.46308044
147Colorectal cancer_Homo sapiens_hsa052100.45511775
148Basal transcription factors_Homo sapiens_hsa030220.45508933
149Alcoholism_Homo sapiens_hsa050340.45303408
150Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44765751
151Selenocompound metabolism_Homo sapiens_hsa004500.43382462
152Gap junction_Homo sapiens_hsa045400.43088610
153Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42010625
154Fanconi anemia pathway_Homo sapiens_hsa034600.41807659
155Maturity onset diabetes of the young_Homo sapiens_hsa049500.41485431
156Glioma_Homo sapiens_hsa052140.41185581
157Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40912369
158Retinol metabolism_Homo sapiens_hsa008300.40909036
159Jak-STAT signaling pathway_Homo sapiens_hsa046300.40867359
160Taste transduction_Homo sapiens_hsa047420.40122159
161Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32599110
162Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30939601
163Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29153780
164Olfactory transduction_Homo sapiens_hsa047400.28910473
165Sulfur metabolism_Homo sapiens_hsa009200.27673161
166Fatty acid metabolism_Homo sapiens_hsa012120.27529205
167Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27380113
168Fatty acid degradation_Homo sapiens_hsa000710.26088341
169Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25012934
170Tyrosine metabolism_Homo sapiens_hsa003500.24374593
171Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.21956973

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