ARL14EPL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-threonine dephosphorylation (GO:0035970)6.74736173
2keratinocyte proliferation (GO:0043616)6.74640067
3regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.64132886
4negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)5.55812855
5positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)5.54096215
6establishment of integrated proviral latency (GO:0075713)5.52314197
7regulation of acyl-CoA biosynthetic process (GO:0050812)4.97291300
8regulation of coenzyme metabolic process (GO:0051196)4.83259321
9regulation of cofactor metabolic process (GO:0051193)4.83259321
10histone H4-K12 acetylation (GO:0043983)4.82977539
11formation of translation preinitiation complex (GO:0001731)4.69796434
12regulation of protein kinase A signaling (GO:0010738)4.67064921
13regulation of epidermal growth factor-activated receptor activity (GO:0007176)4.63500393
14regulation of double-strand break repair via homologous recombination (GO:0010569)4.57513017
15replication fork processing (GO:0031297)4.44943588
16establishment of viral latency (GO:0019043)4.44270118
17regulation of chromatin binding (GO:0035561)4.41510478
18regulation of gene silencing by RNA (GO:0060966)4.39232600
19regulation of posttranscriptional gene silencing (GO:0060147)4.39232600
20regulation of gene silencing by miRNA (GO:0060964)4.39232600
21maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.36628272
22regulation of pigment cell differentiation (GO:0050932)4.36019366
23somatic diversification of immune receptors via somatic mutation (GO:0002566)4.30728408
24somatic hypermutation of immunoglobulin genes (GO:0016446)4.30728408
25lung vasculature development (GO:0060426)4.21095494
26positive regulation of developmental pigmentation (GO:0048087)4.15591067
27dosage compensation (GO:0007549)4.12358196
28ribosome assembly (GO:0042255)4.11930690
29mitotic sister chromatid segregation (GO:0000070)4.11100616
30piRNA metabolic process (GO:0034587)4.08118083
31regulation of sulfur metabolic process (GO:0042762)4.06898285
32mitotic chromosome condensation (GO:0007076)4.01195758
33regulation of mitotic spindle organization (GO:0060236)3.93505611
34protein localization to kinetochore (GO:0034501)3.91658364
35transcription from mitochondrial promoter (GO:0006390)3.90378893
36regulation of double-strand break repair (GO:2000779)3.82932631
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.81902664
38positive regulation of mitotic sister chromatid separation (GO:1901970)3.81682640
39positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.81682640
40positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.81682640
41regulation of nuclear cell cycle DNA replication (GO:0033262)3.81462760
42heterochromatin organization (GO:0070828)3.78818016
43mammary gland epithelial cell proliferation (GO:0033598)3.78381815
44regulation of cilium movement (GO:0003352)3.77368479
45DNA replication checkpoint (GO:0000076)3.73865145
46hypotonic response (GO:0006971)3.72164902
47DNA replication-dependent nucleosome organization (GO:0034723)3.69466312
48DNA replication-dependent nucleosome assembly (GO:0006335)3.69466312
49negative regulation of smooth muscle cell differentiation (GO:0051151)3.68140930
50nuclear pore organization (GO:0006999)3.63641131
51regulation of helicase activity (GO:0051095)3.61451248
52replicative senescence (GO:0090399)3.61251132
53nuclear pore complex assembly (GO:0051292)3.57674496
54proline biosynthetic process (GO:0006561)3.57010953
55ribosomal large subunit biogenesis (GO:0042273)3.56392322
56positive regulation of chromosome segregation (GO:0051984)3.53908430
57synaptonemal complex assembly (GO:0007130)3.52982918
58membrane raft organization (GO:0031579)3.52935233
59histone H4-K8 acetylation (GO:0043982)3.51542781
60histone H4-K5 acetylation (GO:0043981)3.51542781
61nucleobase-containing small molecule interconversion (GO:0015949)3.51111891
62regulation of spindle organization (GO:0090224)3.48831034
63protein localization to chromosome, centromeric region (GO:0071459)3.48512145
64pore complex assembly (GO:0046931)3.46559288
65negative regulation of DNA repair (GO:0045738)3.44322041
66regulation of sister chromatid cohesion (GO:0007063)3.43076320
67regulation of meiosis I (GO:0060631)3.38585535
68sister chromatid segregation (GO:0000819)3.38145115
69pre-miRNA processing (GO:0031054)3.37666916
70mitotic nuclear envelope disassembly (GO:0007077)3.35503158
71determination of adult lifespan (GO:0008340)3.34851541
72skin morphogenesis (GO:0043589)3.32494736
73meiotic chromosome segregation (GO:0045132)3.31765914
74synaptonemal complex organization (GO:0070193)3.30698820
75trophectodermal cell differentiation (GO:0001829)3.29572062
76ribosome biogenesis (GO:0042254)3.29446752
77mRNA cleavage (GO:0006379)3.27015558
78intestinal epithelial cell development (GO:0060576)3.26894275
79mitotic metaphase plate congression (GO:0007080)3.26154766
80negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.26048755
81protein K6-linked ubiquitination (GO:0085020)3.25656310
82establishment of apical/basal cell polarity (GO:0035089)3.25627701
83mitochondrial DNA metabolic process (GO:0032042)3.25138301
84DNA methylation involved in gamete generation (GO:0043046)3.23593474
85DNA replication initiation (GO:0006270)3.22754703
86mitotic sister chromatid cohesion (GO:0007064)3.22254025
87negative regulation of myeloid cell apoptotic process (GO:0033033)3.20571505
88protein insertion into membrane (GO:0051205)3.19360505
89regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.18258131
90activation of Rac GTPase activity (GO:0032863)3.14807646
91negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.14679088
92negative regulation of protein tyrosine kinase activity (GO:0061099)3.14664451
93membrane disassembly (GO:0030397)3.12325740
94nuclear envelope disassembly (GO:0051081)3.12325740
95diterpenoid biosynthetic process (GO:0016102)3.12192906
96cullin deneddylation (GO:0010388)3.11658886
97kinetochore assembly (GO:0051382)3.11603788
98telomere maintenance via semi-conservative replication (GO:0032201)3.09958576
99regulation of telomere maintenance via telomerase (GO:0032210)3.09152339
100protoporphyrinogen IX biosynthetic process (GO:0006782)3.09070048
101DNA strand elongation involved in DNA replication (GO:0006271)3.06073641
102positive regulation of protein homooligomerization (GO:0032464)3.05779689
103regulation of histone H3-K9 methylation (GO:0051570)3.05411994
104positive regulation of cytokinesis (GO:0032467)3.04832608
105regulation of hippo signaling (GO:0035330)3.04768643
106rRNA transcription (GO:0009303)3.03901393
107histone-serine phosphorylation (GO:0035404)3.02938096
108male meiosis (GO:0007140)3.02215848
109notochord development (GO:0030903)3.02144371
110negative regulation of histone methylation (GO:0031061)3.01473887
111embryonic process involved in female pregnancy (GO:0060136)3.01281188
112desmosome organization (GO:0002934)3.01239465
113negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.00970514
114chromatin assembly (GO:0031497)2.99675396
115sensory perception of smell (GO:0007608)2.98987601
116natural killer cell mediated cytotoxicity (GO:0042267)2.97990929
117natural killer cell mediated immunity (GO:0002228)2.97990929
118cellular senescence (GO:0090398)2.97880547
119negative regulation of chromosome segregation (GO:0051985)2.97360465
120establishment or maintenance of monopolar cell polarity (GO:0061339)2.96960785
121establishment of monopolar cell polarity (GO:0061162)2.96960785
122DNA geometric change (GO:0032392)2.96878462
123DNA strand renaturation (GO:0000733)2.96353739
124DNA duplex unwinding (GO:0032508)2.96247285
125protein polyglutamylation (GO:0018095)2.95615392
126kinetochore organization (GO:0051383)2.95568276
127DNA integration (GO:0015074)2.95343700
128interferon-gamma secretion (GO:0072643)2.93837607
129establishment of chromosome localization (GO:0051303)2.92365322
130mammary gland alveolus development (GO:0060749)2.92299972
131chaperone-mediated protein complex assembly (GO:0051131)2.92269324
132inner cell mass cell proliferation (GO:0001833)2.91010663
133hepatocyte differentiation (GO:0070365)2.90920014
134positive regulation of protein import into nucleus, translocation (GO:0033160)2.90697717
135DNA strand elongation (GO:0022616)2.90362683
136L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.89665301
137poly(A)+ mRNA export from nucleus (GO:0016973)2.89056517
138histone arginine methylation (GO:0034969)2.88009656
139cell adhesion mediated by integrin (GO:0033627)2.87594525
140rRNA modification (GO:0000154)2.87430008
141mRNA transport (GO:0051028)2.86043032
142meiotic nuclear division (GO:0007126)2.85758021
143maturation of 5.8S rRNA (GO:0000460)2.85600184
144attachment of spindle microtubules to kinetochore (GO:0008608)2.85564308
145regulation of translational fidelity (GO:0006450)2.85310139
146detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.84907784
147spindle assembly (GO:0051225)2.84682256
148anterior/posterior axis specification, embryo (GO:0008595)2.84464898
149regulation of transforming growth factor beta2 production (GO:0032909)2.84147521
150oocyte maturation (GO:0001556)2.82832860
151regulation of centrosome cycle (GO:0046605)2.82054563
152negative regulation of response to reactive oxygen species (GO:1901032)2.81070207
153regulation of chromosome segregation (GO:0051983)2.80869026
154nucleoside salvage (GO:0043174)2.80776432
155regulation of RNA export from nucleus (GO:0046831)2.80666397
156viral mRNA export from host cell nucleus (GO:0046784)2.79686409
157regulation of mitotic metaphase/anaphase transition (GO:0030071)2.78521614
158telomere maintenance via recombination (GO:0000722)2.78387881
159bone remodeling (GO:0046849)2.77353010
160mitotic cytokinesis (GO:0000281)2.77181347
161DNA topological change (GO:0006265)2.76159172
162metaphase plate congression (GO:0051310)2.75788959
163negative regulation of receptor activity (GO:2000272)2.75739229
164folic acid-containing compound biosynthetic process (GO:0009396)2.73115304
165positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.72660462
166protein localization to chromosome (GO:0034502)2.71992368
167regulation of response to tumor cell (GO:0002834)2.70500993
168positive regulation of response to tumor cell (GO:0002836)2.70500993
169positive regulation of immune response to tumor cell (GO:0002839)2.70500993
170regulation of immune response to tumor cell (GO:0002837)2.70500993
171regulation of hydrogen peroxide-induced cell death (GO:1903205)2.68168148
172Golgi transport vesicle coating (GO:0048200)2.67770757
173COPI coating of Golgi vesicle (GO:0048205)2.67770757
174regulation of protein export from nucleus (GO:0046825)2.66830985
175muscle cell migration (GO:0014812)2.65814059
176regulation of keratinocyte differentiation (GO:0045616)2.64759371
177negative regulation of potassium ion transmembrane transport (GO:1901380)2.64627754
178positive regulation of DNA replication (GO:0045740)2.62788340
179ribonucleoprotein complex biogenesis (GO:0022613)2.59332098
180spindle checkpoint (GO:0031577)2.58981765
181DNA ligation (GO:0006266)2.58581557

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.93028086
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.17211919
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.17211919
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.17211919
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.69658166
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.48965420
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.38632015
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.29662734
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.27888199
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.19437985
11NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.04271404
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.87244189
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.75996892
14SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.66523010
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.65535194
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62566001
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59469575
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.53958191
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.52088667
20SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.40646759
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.39437914
22HIF1A_21447827_ChIP-Seq_MCF-7_Human2.38625743
23NANOG_18555785_ChIP-Seq_MESCs_Mouse2.33881171
24ELK1_19687146_ChIP-ChIP_HELA_Human2.28311373
25TCF3_18692474_ChIP-Seq_MESCs_Mouse2.26236257
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.18876081
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.17983484
28ATF3_27146783_Chip-Seq_COLON_Human2.17687174
29SALL1_21062744_ChIP-ChIP_HESCs_Human2.16659689
30SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.14827336
31SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.14827336
32SOX2_18555785_ChIP-Seq_MESCs_Mouse2.11956790
33STAT3_1855785_ChIP-Seq_MESCs_Mouse2.05844504
34SMAD_19615063_ChIP-ChIP_OVARY_Human2.05142792
35TCF3_18692474_ChIP-Seq_MEFs_Mouse2.04231136
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03710884
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.01817824
38POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.00952149
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.00361803
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.95026006
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94541481
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.94007728
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.92414216
44NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.90452688
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88426279
46FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.87307410
47EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.85869474
48KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.85539419
49NANOG_21062744_ChIP-ChIP_HESCs_Human1.82378838
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.82207216
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80789334
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79178449
53SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.77901084
54POU5F1_16518401_ChIP-PET_MESCs_Mouse1.76622430
55NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.75816253
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75175239
57PPAR_26484153_Chip-Seq_NCI-H1993_Human1.75023696
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.73643444
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.73359813
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.73190575
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70540770
62NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.68393953
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.64347884
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62270897
65HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.59015480
66POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.56369669
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.53666855
68SOX2_18692474_ChIP-Seq_MESCs_Mouse1.51577421
69NANOG_18692474_ChIP-Seq_MESCs_Mouse1.49517124
70ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.46804417
71XRN2_22483619_ChIP-Seq_HELA_Human1.44776608
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43004461
73CREB1_15753290_ChIP-ChIP_HEK293T_Human1.42764940
74KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.42370089
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.41132739
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.40342065
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39686109
78ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39464592
79GABP_17652178_ChIP-ChIP_JURKAT_Human1.38253034
80VDR_23849224_ChIP-Seq_CD4+_Human1.37956461
81TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.37009926
82NANOG_18692474_ChIP-Seq_MEFs_Mouse1.36792110
83PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.34992253
84CTNNB1_20460455_ChIP-Seq_HCT116_Human1.34605015
85ELK1_22589737_ChIP-Seq_MCF10A_Human1.34317373
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34160716
87GABP_19822575_ChIP-Seq_HepG2_Human1.33991547
88BRD4_25478319_ChIP-Seq_HGPS_Human1.33883098
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33855753
90SOX2_18692474_ChIP-Seq_MEFs_Mouse1.33823303
91KDM5A_27292631_Chip-Seq_BREAST_Human1.33397300
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.33263152
93THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32189860
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28593969
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27851626
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27408609
97TTF2_22483619_ChIP-Seq_HELA_Human1.25420225
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25053632
99SOX17_20123909_ChIP-Seq_XEN_Mouse1.24966480
100TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24935335
101JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23112964
102FOXP3_21729870_ChIP-Seq_TREG_Human1.22573606
103DCP1A_22483619_ChIP-Seq_HELA_Human1.22381454
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20281774
105OCT4_18692474_ChIP-Seq_MEFs_Mouse1.19772803
106KAP1_27257070_Chip-Seq_ESCs_Mouse1.18661478
107CJUN_26792858_Chip-Seq_BT549_Human1.18498579
108NANOG_16518401_ChIP-PET_MESCs_Mouse1.18013149
109SOX2_20726797_ChIP-Seq_SW620_Human1.17217512
110ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16622242
111ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14161931
112ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13821230
113PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12642224
114POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.12560441
115ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09107921
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08652348
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08453999
118HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08216521
119SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07393561
120JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07356887
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07201077
122ZNF263_19887448_ChIP-Seq_K562_Human1.06411721
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05094556
124HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04997119
125CLOCK_20551151_ChIP-Seq_293T_Human1.04602678
126TFEB_21752829_ChIP-Seq_HELA_Human1.02814109
127YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02766826
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02634804
129MYC_22102868_ChIP-Seq_BL_Human1.02234951
130CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01896615
131ELF5_23300383_ChIP-Seq_T47D_Human1.00722537
132CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00591928
133ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99990456
134GATA6_25053715_ChIP-Seq_YYC3_Human0.99744334
135BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99724824
136CHD1_26751641_Chip-Seq_LNCaP_Human0.99456992
137CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99076349
138RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98238722
139CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97643116
140SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96378132
141ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94744301
142RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92361755
143ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91962843
144EGR1_19374776_ChIP-ChIP_THP-1_Human0.91306800
145UBF1/2_26484160_Chip-Seq_HMECs_Human0.90064484
146FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.89897312
147AR_21909140_ChIP-Seq_LNCAP_Human0.88748805
148HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87685399
149TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.86761591
150HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.86687960
151EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.85368126
152ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85330823

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004185_abnormal_adipocyte_glucose5.07047654
2MP0008057_abnormal_DNA_replication4.95362088
3MP0003693_abnormal_embryo_hatching3.86596770
4MP0009697_abnormal_copulation3.78855963
5MP0008877_abnormal_DNA_methylation3.75041896
6MP0004957_abnormal_blastocyst_morpholog3.54306415
7MP0010094_abnormal_chromosome_stability3.53915710
8MP0008961_abnormal_basal_metabolism3.26298512
9MP0003111_abnormal_nucleus_morphology3.25030600
10MP0008058_abnormal_DNA_repair2.88618473
11MP0005499_abnormal_olfactory_system2.80421135
12MP0005394_taste/olfaction_phenotype2.80421135
13MP0008789_abnormal_olfactory_epithelium2.70420631
14MP0002653_abnormal_ependyma_morphology2.67283982
15MP0009780_abnormal_chondrocyte_physiolo2.67278761
16MP0003077_abnormal_cell_cycle2.65100803
17MP0003890_abnormal_embryonic-extraembry2.33833242
18MP0010234_abnormal_vibrissa_follicle2.32376911
19MP0010678_abnormal_skin_adnexa2.20231592
20MP0001293_anophthalmia2.18984856
21MP0005666_abnormal_adipose_tissue2.10952544
22MP0008932_abnormal_embryonic_tissue2.06077189
23MP0004133_heterotaxia2.01432176
24MP0010352_gastrointestinal_tract_polyps2.01199101
25MP0003950_abnormal_plasma_membrane2.00679915
26MP0009379_abnormal_foot_pigmentation1.96836269
27MP0003787_abnormal_imprinting1.94392699
28MP0000350_abnormal_cell_proliferation1.93145013
29MP0003786_premature_aging1.91717751
30MP0003718_maternal_effect1.91317069
31MP0001672_abnormal_embryogenesis/_devel1.87564528
32MP0005380_embryogenesis_phenotype1.87564528
33MP0006292_abnormal_olfactory_placode1.84221403
34MP0002085_abnormal_embryonic_tissue1.83719044
35MP0001730_embryonic_growth_arrest1.83672419
36MP0004264_abnormal_extraembryonic_tissu1.83248573
37MP0002210_abnormal_sex_determination1.82636527
38MP0002084_abnormal_developmental_patter1.80838660
39MP0010030_abnormal_orbit_morphology1.80746662
40MP0005164_abnormal_response_to1.79217310
41MP0004808_abnormal_hematopoietic_stem1.74896358
42MP0004272_abnormal_basement_membrane1.66829070
43MP0003806_abnormal_nucleotide_metabolis1.62051856
44MP0002332_abnormal_exercise_endurance1.61850604
45MP0001145_abnormal_male_reproductive1.61346950
46MP0002086_abnormal_extraembryonic_tissu1.61156486
47MP0001697_abnormal_embryo_size1.57929034
48MP0003984_embryonic_growth_retardation1.55194273
49MP0005360_urolithiasis1.54505462
50MP0001929_abnormal_gametogenesis1.53849218
51MP0002088_abnormal_embryonic_growth/wei1.52399776
52MP0003878_abnormal_ear_physiology1.50387498
53MP0005377_hearing/vestibular/ear_phenot1.50387498
54MP0003121_genomic_imprinting1.48313058
55MP0003119_abnormal_digestive_system1.45303489
56MP0001727_abnormal_embryo_implantation1.45083012
57MP0000383_abnormal_hair_follicle1.42646460
58MP0002160_abnormal_reproductive_system1.42478149
59MP0005023_abnormal_wound_healing1.42450890
60MP0002234_abnormal_pharynx_morphology1.42217239
61MP0008995_early_reproductive_senescence1.40628488
62MP0004197_abnormal_fetal_growth/weight/1.37810031
63MP0000490_abnormal_crypts_of1.36773684
64MP0001348_abnormal_lacrimal_gland1.36430309
65MP0001881_abnormal_mammary_gland1.36369048
66MP0003136_yellow_coat_color1.35533760
67MP0000653_abnormal_sex_gland1.35172810
68MP0008007_abnormal_cellular_replicative1.34768460
69MP0005375_adipose_tissue_phenotype1.33560148
70MP0002971_abnormal_brown_adipose1.32832925
71MP0002970_abnormal_white_adipose1.32758569
72MP0002080_prenatal_lethality1.30334871
73MP0002006_tumorigenesis1.27884398
74MP0003567_abnormal_fetal_cardiomyocyte1.20493505
75MP0003698_abnormal_male_reproductive1.20352398
76MP0009278_abnormal_bone_marrow1.18847573
77MP0005501_abnormal_skin_physiology1.17793320
78MP0003943_abnormal_hepatobiliary_system1.17336286
79MP0002249_abnormal_larynx_morphology1.16686179
80MP0004782_abnormal_surfactant_physiolog1.16261209
81MP0005645_abnormal_hypothalamus_physiol1.14709160
82MP0000313_abnormal_cell_death1.14197237
83MP0000627_abnormal_mammary_gland1.13419027
84MP0005075_abnormal_melanosome_morpholog1.13021709
85MP0005389_reproductive_system_phenotype1.12642578
86MP0001216_abnormal_epidermal_layer1.11628073
87MP0003656_abnormal_erythrocyte_physiolo1.11290915
88MP0003828_pulmonary_edema1.10749948
89MP0005410_abnormal_fertilization1.07741842
90MP0002796_impaired_skin_barrier1.07406858
91MP0000858_altered_metastatic_potential1.07405262
92MP0002092_abnormal_eye_morphology1.06608659
93MP0003315_abnormal_perineum_morphology1.02930858
94MP0003191_abnormal_cellular_cholesterol1.01913787
95MP0001873_stomach_inflammation1.01333039
96MP0000733_abnormal_muscle_development1.00303801
97MP0001119_abnormal_female_reproductive0.98856534
98MP0003221_abnormal_cardiomyocyte_apopto0.97874622
99MP0002697_abnormal_eye_size0.96839792
100MP0003861_abnormal_nervous_system0.96830997
101MP0005409_darkened_coat_color0.96779035
102MP0010307_abnormal_tumor_latency0.96480924
103MP0000569_abnormal_digit_pigmentation0.96244672
104MP0005623_abnormal_meninges_morphology0.96186902
105MP0003091_abnormal_cell_migration0.95947614
106MP0000358_abnormal_cell_content/0.94736020
107MP0002233_abnormal_nose_morphology0.94507361
108MP0001485_abnormal_pinna_reflex0.94258514
109MP0002009_preneoplasia0.94210871
110MP0002161_abnormal_fertility/fecundity0.94114208
111MP0003123_paternal_imprinting0.93503692
112MP0001340_abnormal_eyelid_morphology0.93370474
113MP0001286_abnormal_eye_development0.92595506
114MP0003566_abnormal_cell_adhesion0.92393348
115MP0001849_ear_inflammation0.91972550
116MP0009115_abnormal_fat_cell0.91351098
117MP0003755_abnormal_palate_morphology0.89415661
118MP0002019_abnormal_tumor_incidence0.89162894
119MP0003941_abnormal_skin_development0.89065930
120MP0004947_skin_inflammation0.88946779
121MP0009053_abnormal_anal_canal0.88886463
122MP0000537_abnormal_urethra_morphology0.88641679
123MP0000432_abnormal_head_morphology0.88247070
124MP0000750_abnormal_muscle_regeneration0.87201288
125MP0002877_abnormal_melanocyte_morpholog0.85673425
126MP0009703_decreased_birth_body0.83712885
127MP0003705_abnormal_hypodermis_morpholog0.82746362
128MP0005076_abnormal_cell_differentiation0.82474690
129MP0002111_abnormal_tail_morphology0.82141632
130MP0005171_absent_coat_pigmentation0.82119826
131MP0000427_abnormal_hair_cycle0.81130149
132MP0006072_abnormal_retinal_apoptosis0.80873245
133MP0000762_abnormal_tongue_morphology0.79484257
134MP0001542_abnormal_bone_strength0.78432288
135MP0005621_abnormal_cell_physiology0.77242415
136MP0000516_abnormal_urinary_system0.77005895
137MP0005367_renal/urinary_system_phenotyp0.77005895
138MP0008873_increased_physiological_sensi0.77001416
139MP0002127_abnormal_cardiovascular_syste0.76590581
140MP0003936_abnormal_reproductive_system0.76332064
141MP0002932_abnormal_joint_morphology0.76269492
142MP0004233_abnormal_muscle_weight0.76018151
143MP0003935_abnormal_craniofacial_develop0.75392713
144MP0002060_abnormal_skin_morphology0.74803762
145MP0003252_abnormal_bile_duct0.74676171
146MP0003937_abnormal_limbs/digits/tail_de0.73781904
147MP0005391_vision/eye_phenotype0.73517828
148MP0005266_abnormal_metabolism0.73328820
149MP0002114_abnormal_axial_skeleton0.72871137
150MP0003453_abnormal_keratinocyte_physiol0.72153853
151MP0005376_homeostasis/metabolism_phenot0.71847887
152MP0003699_abnormal_female_reproductive0.71633766
153MP0003283_abnormal_digestive_organ0.68930881
154MP0000049_abnormal_middle_ear0.68903166
155MP0005397_hematopoietic_system_phenotyp0.68348424
156MP0001545_abnormal_hematopoietic_system0.68348424
157MP0005257_abnormal_intraocular_pressure0.66999442
158MP0002269_muscular_atrophy0.66510969
159MP0005384_cellular_phenotype0.65812499
160MP0001346_abnormal_lacrimal_gland0.65805450
161MP0000678_abnormal_parathyroid_gland0.64121667

Predicted human phenotypes

RankGene SetZ-score
1Insomnia (HP:0100785)5.02433149
2Diaphragmatic weakness (HP:0009113)4.54602162
3Rib fusion (HP:0000902)4.40049071
4Hypochromic microcytic anemia (HP:0004840)4.16304009
5Ependymoma (HP:0002888)4.06697043
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.03213662
7Abnormality of the labia minora (HP:0012880)4.01079513
8Chromsome breakage (HP:0040012)3.88437933
9Upper limb muscle weakness (HP:0003484)3.80944828
10Supernumerary spleens (HP:0009799)3.72836125
11Abnormality of the lower motor neuron (HP:0002366)3.69131778
12Conjugated hyperbilirubinemia (HP:0002908)3.64910281
13Absent radius (HP:0003974)3.53041814
14Impulsivity (HP:0100710)3.51897134
15Aplasia/hypoplasia of the humerus (HP:0006507)3.51373528
16Rhabdomyosarcoma (HP:0002859)3.48599353
17Subacute progressive viral hepatitis (HP:0006572)3.43440143
18Rectovaginal fistula (HP:0000143)3.42485377
19Rectal fistula (HP:0100590)3.42485377
20Patellar aplasia (HP:0006443)3.41745827
21Progressive external ophthalmoplegia (HP:0000590)3.32900654
22Aplasia involving forearm bones (HP:0009822)3.30000341
23Absent forearm bone (HP:0003953)3.30000341
24Short humerus (HP:0005792)3.29554951
25Abnormality of cells of the erythroid lineage (HP:0012130)3.28528645
26Abnormality of the ileum (HP:0001549)3.28023103
27Tongue fasciculations (HP:0001308)3.27468899
28Aplasia/Hypoplasia of the patella (HP:0006498)3.25406734
29Abnormality of the astrocytes (HP:0100707)3.09178417
30Astrocytoma (HP:0009592)3.09178417
31Neoplasm of the oral cavity (HP:0100649)3.08159684
32Meckel diverticulum (HP:0002245)3.06547223
33Breast hypoplasia (HP:0003187)3.06354146
34Aplasia/Hypoplasia of the uvula (HP:0010293)3.05538173
35Stenosis of the external auditory canal (HP:0000402)3.05508616
36Vaginal fistula (HP:0004320)3.04456912
37Ankyloglossia (HP:0010296)3.01924638
38Medulloblastoma (HP:0002885)3.00231107
39Intestinal fistula (HP:0100819)2.96985040
40Progressive muscle weakness (HP:0003323)2.96319552
41Microglossia (HP:0000171)2.93674568
42Neoplasm of striated muscle (HP:0009728)2.90568488
43Muscle fibrillation (HP:0010546)2.90341152
44Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.90219794
45Vertebral arch anomaly (HP:0008438)2.90203911
46Abnormality of the intrinsic pathway (HP:0010989)2.88504465
47Termporal pattern (HP:0011008)2.88465277
48Insidious onset (HP:0003587)2.88465277
49Right ventricular cardiomyopathy (HP:0011663)2.84821490
50Shawl scrotum (HP:0000049)2.80834483
51Absent thumb (HP:0009777)2.80042034
52Onycholysis (HP:0001806)2.78629072
53Selective tooth agenesis (HP:0001592)2.78311797
54Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.77475195
55Reduced subcutaneous adipose tissue (HP:0003758)2.73528185
56Glioma (HP:0009733)2.72873902
57Subaortic stenosis (HP:0001682)2.69764465
58Abnormality of the left ventricular outflow tract (HP:0011103)2.69764465
59Hypoplasia of the pons (HP:0012110)2.69126985
60Concave nail (HP:0001598)2.66548987
61Missing ribs (HP:0000921)2.63617521
62Birth length less than 3rd percentile (HP:0003561)2.63254089
63Abnormality of the preputium (HP:0100587)2.62001665
64Unilateral renal agenesis (HP:0000122)2.61330683
65Abnormality of chromosome stability (HP:0003220)2.60728230
66Facial hemangioma (HP:0000329)2.60406666
67Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.58453925
68Long foot (HP:0001833)2.56739022
69Choroideremia (HP:0001139)2.55260158
70Abnormality of the gastric mucosa (HP:0004295)2.55123204
71Deviation of the thumb (HP:0009603)2.55019456
72Volvulus (HP:0002580)2.49818930
73Pheochromocytoma (HP:0002666)2.49353481
74Degeneration of anterior horn cells (HP:0002398)2.47829108
75Abnormality of the anterior horn cell (HP:0006802)2.47829108
76Confusion (HP:0001289)2.46782196
77Abnormality of the pons (HP:0007361)2.43459507
78Abnormality of lateral ventricle (HP:0030047)2.43065590
79Increased density of long bones (HP:0006392)2.42752625
80Proximal placement of thumb (HP:0009623)2.39819749
81Premature ovarian failure (HP:0008209)2.38898033
82Increased nuchal translucency (HP:0010880)2.37383903
83Glucose intolerance (HP:0000833)2.36436662
84Spinal muscular atrophy (HP:0007269)2.32608878
85Abnormal respiratory epithelium morphology (HP:0012253)2.32399507
86Abnormal respiratory motile cilium morphology (HP:0005938)2.32399507
87Bilateral microphthalmos (HP:0007633)2.30562504
88Nephroblastoma (Wilms tumor) (HP:0002667)2.30374090
89Hyponatremia (HP:0002902)2.29985043
90Chronic bronchitis (HP:0004469)2.29688612
91Breast aplasia (HP:0100783)2.27568061
92Cortical dysplasia (HP:0002539)2.26420821
93Abnormality of oral frenula (HP:0000190)2.25221626
94Neuroendocrine neoplasm (HP:0100634)2.22992807
95Sloping forehead (HP:0000340)2.18799537
96Small intestinal stenosis (HP:0012848)2.14363477
97Duodenal stenosis (HP:0100867)2.14363477
98Aplasia/Hypoplasia involving the musculature (HP:0001460)2.14340298
99Micronodular cirrhosis (HP:0001413)2.14226311
100Carpal bone hypoplasia (HP:0001498)2.12709824
101Palpitations (HP:0001962)2.12360318
102Trismus (HP:0000211)2.12150465
103Multiple enchondromatosis (HP:0005701)2.11739561
104Abnormal number of incisors (HP:0011064)2.08342775
105Pili torti (HP:0003777)2.07277954
106Abnormal auditory evoked potentials (HP:0006958)2.06755385
107Large hands (HP:0001176)2.06472929
108Embryonal renal neoplasm (HP:0011794)2.05756749
109Entropion (HP:0000621)2.05564394
110Broad alveolar ridges (HP:0000187)2.04082786
111Abdominal situs inversus (HP:0003363)2.03934958
112Abnormality of abdominal situs (HP:0011620)2.03934958
113Vertebral fusion (HP:0002948)2.03548081
114Abnormality of alanine metabolism (HP:0010916)2.02910237
115Hyperalaninemia (HP:0003348)2.02910237
116Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02910237
117Median cleft lip (HP:0000161)2.02690422
118Short chin (HP:0000331)2.02432112
119Sensory axonal neuropathy (HP:0003390)2.01292500
120Sex reversal (HP:0012245)2.01151036
121Abnormal sex determination (HP:0012244)2.01151036
122Curly hair (HP:0002212)2.00981015
123Supernumerary ribs (HP:0005815)1.98875623
124Squamous cell carcinoma (HP:0002860)1.98411416
125Aplasia/Hypoplasia of the breasts (HP:0010311)1.98108360
126Hemivertebrae (HP:0002937)1.97915245
127Atresia of the external auditory canal (HP:0000413)1.97576688
128Short nail (HP:0001799)1.96745499
129Cortical visual impairment (HP:0100704)1.96660043
130Delusions (HP:0000746)1.96197866
131Abnormality of the salivary glands (HP:0010286)1.95785294
132Poikiloderma (HP:0001029)1.95273268
133Cystic hygroma (HP:0000476)1.94819312
134Prominent nose (HP:0000448)1.93923994
135Esophageal atresia (HP:0002032)1.92195781
136Gastrointestinal atresia (HP:0002589)1.91926178
137Aplasia/Hypoplasia of the sternum (HP:0006714)1.90345483
138Ulnar bowing (HP:0003031)1.90111793
139Elfin facies (HP:0004428)1.89981921
140Basal cell carcinoma (HP:0002671)1.89603443
141Pelvic girdle muscle weakness (HP:0003749)1.89079279
142Supernumerary bones of the axial skeleton (HP:0009144)1.88238314
143Agnosia (HP:0010524)1.87363884
144Thin skin (HP:0000963)1.85558822
145Aplasia/Hypoplasia of the sacrum (HP:0008517)1.85232095
146Abnormality of the parietal bone (HP:0002696)1.84629221
147Hypochromic anemia (HP:0001931)1.84504104
148Heterotopia (HP:0002282)1.84488821
149Abnormal hemoglobin (HP:0011902)1.84448559
150Neoplasm of the peripheral nervous system (HP:0100007)1.83425681
151Decreased testicular size (HP:0008734)1.82402580
152Abnormality of the carotid arteries (HP:0005344)1.82284366
153Facial cleft (HP:0002006)1.82244522
154Abnormal respiratory motile cilium physiology (HP:0012261)1.81757348
155Hypoplasia of the radius (HP:0002984)1.81392840
156Tracheoesophageal fistula (HP:0002575)1.81277724
157Myelodysplasia (HP:0002863)1.81005959
158Orthostatic hypotension (HP:0001278)1.79944558
159Glossoptosis (HP:0000162)1.79710931
160Acute myeloid leukemia (HP:0004808)1.78975972
161Deep philtrum (HP:0002002)1.77640740
162Hand muscle atrophy (HP:0009130)1.77366133
163Male infertility (HP:0003251)1.77218492
164Fused cervical vertebrae (HP:0002949)1.76863861
165Triphalangeal thumb (HP:0001199)1.75636461
166Cerebral hypomyelination (HP:0006808)1.75626729
167Poor speech (HP:0002465)1.75488118
168Abnormality of the duodenum (HP:0002246)1.74433248
169Aplasia cutis congenita (HP:0001057)1.74286021
170Cafe-au-lait spot (HP:0000957)1.74159554
171Relative macrocephaly (HP:0004482)1.73594406
172Abnormality of the distal phalanges of the toes (HP:0010182)1.71265049
173Bundle branch block (HP:0011710)1.70960009
174Chorioretinal atrophy (HP:0000533)1.70363026
175Low posterior hairline (HP:0002162)1.70274568
176Freckling (HP:0001480)1.69676764
177Generalized hyperpigmentation (HP:0007440)1.69516830
178Premature graying of hair (HP:0002216)1.69435788
179Abnormality of the common coagulation pathway (HP:0010990)1.68388297
180Postnatal microcephaly (HP:0005484)1.67502802
181Abnormal glucose tolerance (HP:0001952)1.65629876

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R8.40017181
2MST45.97299966
3CDK124.86105242
4MET3.70359244
5ICK3.22626725
6EPHA23.15274184
7TTK3.04020996
8STK392.89412872
9MAPK152.87139356
10PBK2.78035645
11NEK22.64217210
12WEE12.60345028
13CDC72.54902108
14MAP3K62.48347395
15AKT32.38995883
16TYRO32.37371242
17WNK42.34662782
18NME22.27375174
19PLK12.19801021
20CHEK22.17314997
21EIF2AK32.12995365
22CDK72.09864870
23MAPKAPK32.06847863
24DYRK31.99157866
25TNIK1.94049115
26DDR21.92079725
27EEF2K1.89121058
28EIF2AK11.85323792
29PLK41.79819156
30RPS6KB21.75858071
31SRPK11.75180323
32MAP3K121.73811940
33MATK1.73507922
34BUB11.68121414
35SIK31.62576160
36SIK11.55819043
37NEK11.52471014
38FGFR11.50120813
39STK38L1.50080175
40ERBB41.45621692
41BRSK11.40032713
42SCYL21.36072456
43TRIM281.34961425
44AURKA1.34726241
45ERBB31.33098444
46CHEK11.30850944
47PNCK1.26296618
48LATS21.25050773
49CDK41.22298278
50ATR1.21612310
51ACVR1B1.18180919
52EIF2AK21.17921511
53GRK51.16865683
54PDK31.15347548
55PDK41.15347548
56CDK81.11007429
57MAP3K111.10379472
58AURKB1.08780795
59PINK11.08673362
60TLK11.06633563
61CCNB11.05719761
62DAPK11.04157034
63CDK20.97570989
64CDK60.96891862
65MTOR0.95008462
66PDK20.94312703
67LRRK20.93932231
68PTK20.92647526
69PIM10.91526836
70ATM0.87551594
71MAP3K100.87033620
72TRPM70.86384885
73GRK60.85726045
74PRKD20.84458662
75DYRK20.82485349
76FGR0.81979613
77BRD40.81848084
78PRKCI0.81359434
79YES10.80062963
80MAP3K80.78297789
81CSK0.77686309
82MKNK20.77224204
83GRK10.76485861
84ALK0.76132391
85BCR0.75754627
86SIK20.74921285
87STK100.73697039
88PLK30.73395641
89MAP3K90.72948358
90STK380.71368846
91BMX0.71065024
92MELK0.69764526
93EPHB10.67523988
94DYRK1B0.66866830
95IRAK30.66768040
96PAK40.65480596
97MAPK110.63478116
98CDK10.61489448
99PDGFRA0.60075527
100CSNK2A10.58863918
101STK160.58806986
102CSNK1E0.58423344
103RPS6KA40.58369832
104WNK10.58346035
105TESK10.57950098
106MKNK10.56749966
107STK30.56584228
108PHKG10.55603711
109PHKG20.55603711
110LIMK10.51592452
111PIM20.51495520
112ZAK0.51472597
113ABL20.51431815
114CSNK2A20.51405032
115PAK10.50985186
116MAP3K20.50491513
117AKT20.48918073
118CSNK1G10.48738860
119EPHB20.48215966
120CDK30.47499635
121LMTK20.46330626
122PRKAA10.45897800
123STK240.45010130
124TESK20.43820175
125VRK10.43037632
126ADRBK20.42796465
127TAF10.42038748
128CDK90.41854501
129STK40.41292893
130MAPK140.40904151
131LATS10.40753737
132MAPK100.40744314
133TSSK60.40422958
134GSK3B0.39220208
135BRAF0.37731438
136MOS0.37690827
137BRSK20.37005115
138BMPR20.35795664
139UHMK10.34987832
140KSR10.34833603
141MAP3K140.33951755
142RIPK10.33091914
143RPS6KA10.32930304
144BMPR1B0.32346026
145FLT30.29096801
146EGFR0.25620059
147NME10.24315011
148ROCK20.22991580
149NEK60.21046613
150ROCK10.20128852
151NEK90.17932309
152ADRBK10.16073820

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.49711409
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.21570624
3DNA replication_Homo sapiens_hsa030304.09501807
4RNA transport_Homo sapiens_hsa030133.52738687
5Base excision repair_Homo sapiens_hsa034103.27942762
6Fanconi anemia pathway_Homo sapiens_hsa034603.13882811
7Homologous recombination_Homo sapiens_hsa034403.13282485
8Spliceosome_Homo sapiens_hsa030402.98072010
9Cell cycle_Homo sapiens_hsa041102.68419777
10mRNA surveillance pathway_Homo sapiens_hsa030152.63534933
11Nucleotide excision repair_Homo sapiens_hsa034202.61940272
12RNA polymerase_Homo sapiens_hsa030202.35155888
13Basal transcription factors_Homo sapiens_hsa030222.35013255
14Vitamin B6 metabolism_Homo sapiens_hsa007501.97018586
15Proteasome_Homo sapiens_hsa030501.96808411
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89587582
17p53 signaling pathway_Homo sapiens_hsa041151.87347491
18Alcoholism_Homo sapiens_hsa050341.79030524
19Non-homologous end-joining_Homo sapiens_hsa034501.77363255
20RNA degradation_Homo sapiens_hsa030181.76007644
21One carbon pool by folate_Homo sapiens_hsa006701.75325368
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.60422654
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.57985859
24Ribosome_Homo sapiens_hsa030101.57256177
25Pyrimidine metabolism_Homo sapiens_hsa002401.53794754
26Fatty acid biosynthesis_Homo sapiens_hsa000611.47552813
27Fructose and mannose metabolism_Homo sapiens_hsa000511.43247102
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.39596615
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.38696294
30Proteoglycans in cancer_Homo sapiens_hsa052051.37595316
31Oocyte meiosis_Homo sapiens_hsa041141.31636876
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.29420130
33Folate biosynthesis_Homo sapiens_hsa007901.26293419
34Notch signaling pathway_Homo sapiens_hsa043301.24210495
35Hippo signaling pathway_Homo sapiens_hsa043901.21699150
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.20554699
37ErbB signaling pathway_Homo sapiens_hsa040121.20474747
38mTOR signaling pathway_Homo sapiens_hsa041501.18426509
39Hedgehog signaling pathway_Homo sapiens_hsa043401.17323497
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15048286
41Pancreatic cancer_Homo sapiens_hsa052121.07048723
42Phenylalanine metabolism_Homo sapiens_hsa003601.04147839
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.96669092
44Adherens junction_Homo sapiens_hsa045200.96447972
45Sulfur relay system_Homo sapiens_hsa041220.92299301
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91715203
47Regulation of autophagy_Homo sapiens_hsa041400.89138346
48Arachidonic acid metabolism_Homo sapiens_hsa005900.88486752
49Epstein-Barr virus infection_Homo sapiens_hsa051690.87405807
50Tight junction_Homo sapiens_hsa045300.86672175
51TGF-beta signaling pathway_Homo sapiens_hsa043500.85499661
52Renal cell carcinoma_Homo sapiens_hsa052110.85009199
53Biosynthesis of amino acids_Homo sapiens_hsa012300.84330765
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83297370
55Basal cell carcinoma_Homo sapiens_hsa052170.82884643
56Linoleic acid metabolism_Homo sapiens_hsa005910.80358873
57Purine metabolism_Homo sapiens_hsa002300.78995947
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77798844
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75804285
60N-Glycan biosynthesis_Homo sapiens_hsa005100.74877352
61Melanogenesis_Homo sapiens_hsa049160.74777161
62Viral carcinogenesis_Homo sapiens_hsa052030.74665785
63Herpes simplex infection_Homo sapiens_hsa051680.74188363
64Sulfur metabolism_Homo sapiens_hsa009200.73444955
65MicroRNAs in cancer_Homo sapiens_hsa052060.73226493
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72688283
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70483570
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68549944
69Selenocompound metabolism_Homo sapiens_hsa004500.67352180
70Sphingolipid metabolism_Homo sapiens_hsa006000.65250319
71Colorectal cancer_Homo sapiens_hsa052100.65130212
72African trypanosomiasis_Homo sapiens_hsa051430.64550660
73Arginine and proline metabolism_Homo sapiens_hsa003300.62431314
74Pyruvate metabolism_Homo sapiens_hsa006200.61838358
75Wnt signaling pathway_Homo sapiens_hsa043100.60380702
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59375085
77Carbon metabolism_Homo sapiens_hsa012000.56476582
78Salmonella infection_Homo sapiens_hsa051320.55375316
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55316516
80Glutathione metabolism_Homo sapiens_hsa004800.53679139
81Protein export_Homo sapiens_hsa030600.51645290
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51624320
83Olfactory transduction_Homo sapiens_hsa047400.51534220
84Endocytosis_Homo sapiens_hsa041440.50664377
85Thyroid cancer_Homo sapiens_hsa052160.50388174
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.50130957
87HTLV-I infection_Homo sapiens_hsa051660.48198499
88Axon guidance_Homo sapiens_hsa043600.48164005
89Hepatitis C_Homo sapiens_hsa051600.47976665
90Dorso-ventral axis formation_Homo sapiens_hsa043200.47681482
91Influenza A_Homo sapiens_hsa051640.46731178
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46203462
93Bladder cancer_Homo sapiens_hsa052190.46182342
94TNF signaling pathway_Homo sapiens_hsa046680.41860541
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40225294
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40217564
97Pentose phosphate pathway_Homo sapiens_hsa000300.37582063
98Circadian rhythm_Homo sapiens_hsa047100.37302235
99Pathways in cancer_Homo sapiens_hsa052000.36446489
100Huntingtons disease_Homo sapiens_hsa050160.35603128
101Measles_Homo sapiens_hsa051620.34811960
102Melanoma_Homo sapiens_hsa052180.33504784
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.33130284
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32659708
105Galactose metabolism_Homo sapiens_hsa000520.32014635
106Systemic lupus erythematosus_Homo sapiens_hsa053220.31878017
107Lysine degradation_Homo sapiens_hsa003100.31567321
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.31445007
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28957063
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26869358
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26363310
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25889477
113AMPK signaling pathway_Homo sapiens_hsa041520.25730838
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25514648
115Shigellosis_Homo sapiens_hsa051310.24817352
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24076365
117Apoptosis_Homo sapiens_hsa042100.23484818
118Small cell lung cancer_Homo sapiens_hsa052220.23059824
119Legionellosis_Homo sapiens_hsa051340.21442456
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.19451000
121Cyanoamino acid metabolism_Homo sapiens_hsa004600.18651678
122Prostate cancer_Homo sapiens_hsa052150.18340087
123Inositol phosphate metabolism_Homo sapiens_hsa005620.17226736
124FoxO signaling pathway_Homo sapiens_hsa040680.16724493
125Metabolic pathways_Homo sapiens_hsa011000.14207672
126Choline metabolism in cancer_Homo sapiens_hsa052310.13082261
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.11530393
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11446850
129Endometrial cancer_Homo sapiens_hsa052130.11242698
130Phototransduction_Homo sapiens_hsa047440.10786902
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10369476
132Chronic myeloid leukemia_Homo sapiens_hsa052200.09915567

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