ARL15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)6.01433579
2positive regulation of dendritic spine morphogenesis (GO:0061003)5.90022350
3layer formation in cerebral cortex (GO:0021819)5.48249657
4vocalization behavior (GO:0071625)5.01155146
5thrombin receptor signaling pathway (GO:0070493)4.91914034
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.85714195
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.80824860
8regulation of dendritic spine morphogenesis (GO:0061001)4.68025276
9regulation of glutamate receptor signaling pathway (GO:1900449)4.66519941
10locomotory exploration behavior (GO:0035641)4.60320506
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.52518439
12regulation of short-term neuronal synaptic plasticity (GO:0048172)4.38821323
13positive regulation of synapse maturation (GO:0090129)4.34595220
14regulation of cAMP-dependent protein kinase activity (GO:2000479)4.34069730
15cochlea development (GO:0090102)4.24536068
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.20339559
17regulation of long-term neuronal synaptic plasticity (GO:0048169)4.08375132
18synaptic vesicle maturation (GO:0016188)4.06899785
19glutamate receptor signaling pathway (GO:0007215)4.06131846
20protein localization to synapse (GO:0035418)4.02379829
21exploration behavior (GO:0035640)4.01930566
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.01424512
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.00082144
24innervation (GO:0060384)3.94266842
25glutamate secretion (GO:0014047)3.83551865
26dendritic spine morphogenesis (GO:0060997)3.81334150
27regulation of Golgi to plasma membrane protein transport (GO:0042996)3.78229223
28neuron recognition (GO:0008038)3.71924069
29pyrimidine nucleobase catabolic process (GO:0006208)3.70791193
30platelet dense granule organization (GO:0060155)3.66418537
31positive regulation of dendritic spine development (GO:0060999)3.65472197
32neuron cell-cell adhesion (GO:0007158)3.64535257
33fatty acid elongation (GO:0030497)3.62159617
34axonal fasciculation (GO:0007413)3.59796376
35synaptic transmission, glutamatergic (GO:0035249)3.59151682
36regulation of neuronal synaptic plasticity (GO:0048168)3.58973727
37sequestering of actin monomers (GO:0042989)3.58788753
38cell migration in hindbrain (GO:0021535)3.58324670
39behavioral defense response (GO:0002209)3.55868838
40behavioral fear response (GO:0001662)3.55868838
41negative regulation of heart rate (GO:0010459)3.53462843
42synaptic vesicle exocytosis (GO:0016079)3.52311091
43neurotransmitter-gated ion channel clustering (GO:0072578)3.51865712
44regulation of synapse structural plasticity (GO:0051823)3.51677096
45regulation of dendritic spine development (GO:0060998)3.50693672
46nerve growth factor signaling pathway (GO:0038180)3.48850141
47DNA double-strand break processing (GO:0000729)3.46584891
48long-term memory (GO:0007616)3.41805555
49regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.40983149
50ephrin receptor signaling pathway (GO:0048013)3.40529390
51regulation of synaptic vesicle exocytosis (GO:2000300)3.37340243
52inner ear receptor cell development (GO:0060119)3.35788240
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.33122669
54detection of calcium ion (GO:0005513)3.32006366
55nucleobase catabolic process (GO:0046113)3.30671759
56positive regulation of dendrite morphogenesis (GO:0050775)3.29664038
57positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.29241462
58neuron-neuron synaptic transmission (GO:0007270)3.29225403
59G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.27923650
60fear response (GO:0042596)3.27362667
61microtubule depolymerization (GO:0007019)3.27070088
62mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.24807938
63positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.24807938
64phospholipid homeostasis (GO:0055091)3.22082195
65regulation of postsynaptic membrane potential (GO:0060078)3.21988788
66negative regulation of norepinephrine secretion (GO:0010700)3.19806159
67dendritic spine organization (GO:0097061)3.18700245
68response to histamine (GO:0034776)3.18197278
69proline transport (GO:0015824)3.16373751
70central nervous system projection neuron axonogenesis (GO:0021952)3.14195354
71regulation of synaptic vesicle transport (GO:1902803)3.12597641
72positive regulation of membrane potential (GO:0045838)3.10049294
73dopamine transport (GO:0015872)3.09927141
74regulation of synaptic plasticity (GO:0048167)3.08472714
75keratinocyte development (GO:0003334)3.07664157
76regulation of integrin-mediated signaling pathway (GO:2001044)3.06903539
77intra-Golgi vesicle-mediated transport (GO:0006891)3.05451732
78positive regulation of neurotransmitter secretion (GO:0001956)3.04362268
79negative regulation of catecholamine secretion (GO:0033604)3.01887423
80protein localization to cilium (GO:0061512)3.00740724
81positive regulation of muscle hypertrophy (GO:0014742)3.00149279
82positive regulation of cardiac muscle hypertrophy (GO:0010613)3.00149279
83regulation of synapse maturation (GO:0090128)2.98701254
84long-term synaptic potentiation (GO:0060291)2.97390039
85positive regulation of cardiac muscle cell differentiation (GO:2000727)2.96014600
86synaptic vesicle endocytosis (GO:0048488)2.95951354
87neurotransmitter secretion (GO:0007269)2.95567439
88triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.91932728
89positive regulation of endothelial cell differentiation (GO:0045603)2.91705704
90negative regulation of appetite (GO:0032099)2.91374424
91negative regulation of response to food (GO:0032096)2.91374424
92dendrite morphogenesis (GO:0048813)2.85033553
93establishment of nucleus localization (GO:0040023)2.83652585
94regulation of synaptic transmission, glutamatergic (GO:0051966)2.82495081
95regulation of lipoprotein metabolic process (GO:0050746)2.82105979
96positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.81752654
97reverse cholesterol transport (GO:0043691)2.79946155
98chemosensory behavior (GO:0007635)2.79521843
99negative regulation of neurotransmitter transport (GO:0051589)2.79490796
100gamma-aminobutyric acid signaling pathway (GO:0007214)2.78457845
101protein targeting to Golgi (GO:0000042)2.78353071
102positive regulation of amino acid transport (GO:0051957)2.77958620
103postsynaptic membrane organization (GO:0001941)2.77861906
104pigment granule transport (GO:0051904)2.76695748
105establishment of pigment granule localization (GO:0051905)2.75448040
106regulation of acyl-CoA biosynthetic process (GO:0050812)2.75381463
107anterior/posterior axis specification, embryo (GO:0008595)2.75224428
108regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.74376226
109G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.74217471
110axon extension (GO:0048675)2.74029138
111melanosome transport (GO:0032402)2.73554131
112positive regulation of dendrite development (GO:1900006)2.72738207
113establishment of melanosome localization (GO:0032401)2.72392510
114gamma-aminobutyric acid transport (GO:0015812)2.70997813
115transferrin transport (GO:0033572)2.70807029
116neuromuscular process controlling balance (GO:0050885)2.70719339
117glycosphingolipid biosynthetic process (GO:0006688)2.70420110
118high-density lipoprotein particle remodeling (GO:0034375)2.69994052
119neural tube formation (GO:0001841)2.69364239
120establishment of protein localization to Golgi (GO:0072600)2.68474258
121vesicle transport along microtubule (GO:0047496)2.66447129
122glial cell proliferation (GO:0014009)2.66243428
123positive regulation of fibroblast migration (GO:0010763)2.66207361
124negative regulation of cation channel activity (GO:2001258)2.65797816
125serotonin metabolic process (GO:0042428)2.65734818
126neuron fate determination (GO:0048664)2.65533797
127learning (GO:0007612)2.65049531
128negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.64583822
129regulation of Rac GTPase activity (GO:0032314)2.63447179
130dopamine receptor signaling pathway (GO:0007212)2.62775763
131retrograde transport, vesicle recycling within Golgi (GO:0000301)2.61035192
132regulation of synapse organization (GO:0050807)2.60415522
133ferric iron transport (GO:0015682)2.60044263
134trivalent inorganic cation transport (GO:0072512)2.60044263
135clathrin coat assembly (GO:0048268)2.59340601
136positive regulation of mitochondrial fission (GO:0090141)2.58568591
137positive regulation of neurotransmitter transport (GO:0051590)2.58521302
138long term synaptic depression (GO:0060292)2.56525052
139neutrophil activation involved in immune response (GO:0002283)2.56075792
140regulation of clathrin-mediated endocytosis (GO:2000369)2.55198849
141negative regulation of neurological system process (GO:0031645)2.54941100
142positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.53366191
143positive regulation of synaptic transmission, GABAergic (GO:0032230)2.53041767
144regulation of memory T cell differentiation (GO:0043380)2.52917990
145negative regulation of protein localization to cell surface (GO:2000009)2.52892777
146auditory behavior (GO:0031223)2.52670216
147regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.52520563
148dendrite development (GO:0016358)2.51708346
149positive regulation of glycolytic process (GO:0045821)2.51306992
150cellular potassium ion homeostasis (GO:0030007)2.50998068
151regulation of glucokinase activity (GO:0033131)2.50206031
152regulation of hexokinase activity (GO:1903299)2.50206031
153organelle transport along microtubule (GO:0072384)2.50061884
154neuron projection extension (GO:1990138)2.49614088
155sialylation (GO:0097503)2.48627855
156negative regulation of microtubule polymerization (GO:0031115)2.47100983
157peptidyl-cysteine modification (GO:0018198)2.45560019
158regulation of coenzyme metabolic process (GO:0051196)2.44070068
159regulation of cofactor metabolic process (GO:0051193)2.44070068
160positive regulation of synaptic transmission (GO:0050806)2.43400884
161vesicle localization (GO:0051648)2.43079005
162low-density lipoprotein particle remodeling (GO:0034374)2.43037772
163regulation of dendrite morphogenesis (GO:0048814)2.42193499
164regulation of female receptivity (GO:0045924)2.41933935
165long-chain fatty acid biosynthetic process (GO:0042759)2.41678180
166synapse assembly (GO:0007416)2.41333493
167blood coagulation, intrinsic pathway (GO:0007597)2.40769202
168regulation of sulfur metabolic process (GO:0042762)2.40572978
169pigment granule localization (GO:0051875)2.40230058
170lymph vessel development (GO:0001945)2.40224329
171cellular response to leptin stimulus (GO:0044320)2.39473066
172prostate gland growth (GO:0060736)2.38854762
173regulation of transforming growth factor beta2 production (GO:0032909)2.38850839
174social behavior (GO:0035176)2.37681784
175intraspecies interaction between organisms (GO:0051703)2.37681784
176adaptation of signaling pathway (GO:0023058)2.37555518
177negative regulation of catenin import into nucleus (GO:0035414)2.36887689
178melanosome localization (GO:0032400)2.35961740
179iron ion transport (GO:0006826)2.35579296
180anterograde synaptic vesicle transport (GO:0048490)2.35400644
181lipid particle organization (GO:0034389)2.33572575
182positive regulation of insulin receptor signaling pathway (GO:0046628)2.33289502
183neuronal action potential propagation (GO:0019227)2.30372983
184vesicle docking (GO:0048278)2.30261657
185regulation of sarcomere organization (GO:0060297)2.28703465
186negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.28097357
187negative regulation of blood circulation (GO:1903523)2.27889318
188negative regulation of protein localization to plasma membrane (GO:1903077)2.27536910
189regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.27351406
190glycerophospholipid catabolic process (GO:0046475)2.26179902
191negative regulation of dendrite development (GO:2000171)2.25976092
192protein prenylation (GO:0018342)2.25909760
193prenylation (GO:0097354)2.25909760
194positive regulation of protein homodimerization activity (GO:0090073)2.25907756
195myelin assembly (GO:0032288)2.25465433

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.35757894
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.46424337
3GBX2_23144817_ChIP-Seq_PC3_Human3.45289894
4TAF15_26573619_Chip-Seq_HEK293_Human2.98278961
5IGF1R_20145208_ChIP-Seq_DFB_Human2.85985172
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.55672102
7FUS_26573619_Chip-Seq_HEK293_Human2.43436633
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.42053379
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.38931127
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.22780925
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21171623
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21171623
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.19008408
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15497259
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12579288
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.12442561
17SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.12390994
18* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.07871506
19VDR_22108803_ChIP-Seq_LS180_Human2.07683643
20CDX2_19796622_ChIP-Seq_MESCs_Mouse2.07453792
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.05181287
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02784887
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.00465598
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00079493
25SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.98829181
26REST_21632747_ChIP-Seq_MESCs_Mouse1.94653435
27WT1_19549856_ChIP-ChIP_CCG9911_Human1.93657897
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.92567231
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90058905
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.89302321
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.87990397
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.86388318
33AR_21572438_ChIP-Seq_LNCaP_Human1.85508665
34* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83587379
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81613597
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81550929
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.79670317
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.72448269
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.72005516
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.71920911
41HTT_18923047_ChIP-ChIP_STHdh_Human1.71726534
42MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68366102
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.68312704
44TP53_16413492_ChIP-PET_HCT116_Human1.66714393
45* SMAD4_21799915_ChIP-Seq_A2780_Human1.63290704
46* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.62705426
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.62642621
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61088525
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.60798151
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.60730809
51ER_23166858_ChIP-Seq_MCF-7_Human1.58752654
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58472063
53ZFP281_18757296_ChIP-ChIP_E14_Mouse1.57385205
54AHR_22903824_ChIP-Seq_MCF-7_Human1.54815694
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.54229183
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.54026406
57* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53545128
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.53066061
59ELK1_19687146_ChIP-ChIP_HELA_Human1.52501205
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52121011
61DROSHA_22980978_ChIP-Seq_HELA_Human1.51866502
62P300_19829295_ChIP-Seq_ESCs_Human1.48417447
63P53_22387025_ChIP-Seq_ESCs_Mouse1.47399744
64RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.47049329
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46789109
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.45720826
67SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.45699210
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45542887
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.45184754
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.45184754
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45049301
72RING1B_27294783_Chip-Seq_NPCs_Mouse1.44316183
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44291290
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42376980
75E2F1_18555785_Chip-Seq_ESCs_Mouse1.41170847
76ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.40706853
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.40427060
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.39651584
79CMYC_18555785_Chip-Seq_ESCs_Mouse1.39593190
80JUN_21703547_ChIP-Seq_K562_Human1.38770493
81SUZ12_18555785_Chip-Seq_ESCs_Mouse1.36181427
82KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36115742
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34838360
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.33915472
85ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33459050
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.31380649
87TAL1_26923725_Chip-Seq_HPCs_Mouse1.31229239
88* TCF4_23295773_ChIP-Seq_U87_Human1.30603368
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.30410107
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29633677
91CBP_20019798_ChIP-Seq_JUKART_Human1.29633677
92BCAT_22108803_ChIP-Seq_LS180_Human1.29397475
93* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.29084144
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28907303
95RING1B_27294783_Chip-Seq_ESCs_Mouse1.28046893
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27839133
97* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27633390
98PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27291514
99ZNF263_19887448_ChIP-Seq_K562_Human1.26957230
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26273446
101SOX2_21211035_ChIP-Seq_LN229_Gbm1.25969556
102ZNF274_21170338_ChIP-Seq_K562_Hela1.25902288
103* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.25281267
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24703788
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.24007272
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23840040
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23807673
108PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23595820
109EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.22688487
110KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22223552
111TCF4_22108803_ChIP-Seq_LS180_Human1.22131065
112STAT3_18555785_Chip-Seq_ESCs_Mouse1.21747480
113* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21541486
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21419144
115OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20867707
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19873843
117* SALL4_22934838_ChIP-ChIP_CD34+_Human1.19603714
118AR_19668381_ChIP-Seq_PC3_Human1.19575257
119NANOG_19829295_ChIP-Seq_ESCs_Human1.19542711
120SOX2_19829295_ChIP-Seq_ESCs_Human1.19542711
121* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19422818
122AR_25329375_ChIP-Seq_VCAP_Human1.18774636
123TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18384844
124ERG_21242973_ChIP-ChIP_JURKAT_Human1.18264982
125* STAT3_23295773_ChIP-Seq_U87_Human1.18129593
126TP53_18474530_ChIP-ChIP_U2OS_Human1.17585933
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17161697
128* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16552910
129PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16305490
130P300_18555785_Chip-Seq_ESCs_Mouse1.16298232
131ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16183562
132GATA1_22025678_ChIP-Seq_K562_Human1.15919978
133CRX_20693478_ChIP-Seq_RETINA_Mouse1.15671967
134EWS_26573619_Chip-Seq_HEK293_Human1.15251160
135TRIM28_21343339_ChIP-Seq_HEK293_Human1.14868782
136SOX2_18555785_Chip-Seq_ESCs_Mouse1.14468173
137OCT4_18555785_Chip-Seq_ESCs_Mouse1.13765405
138CDX2_22108803_ChIP-Seq_LS180_Human1.13758505
139RNF2_27304074_Chip-Seq_NSC_Mouse1.13629389
140POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13355475
141RUNX2_22187159_ChIP-Seq_PCA_Human1.13075041
142NMYC_18555785_Chip-Seq_ESCs_Mouse1.13065614
143TCF4_18268006_ChIP-ChIP_LS174T_Human1.12810720
144KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.12699284
145KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.12699284
146KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.12699284
147CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12588676
148* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.12336894
149NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11933611
150* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10970826
151TBL1_22424771_ChIP-Seq_293T_Human1.10846067
152* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10482646
153PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10430631
154NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10346103
155FLI1_21867929_ChIP-Seq_TH2_Mouse1.10266045
156POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.10065825
157KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09133783
158IRF1_19129219_ChIP-ChIP_H3396_Human1.07798682
159ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07734735
160TBX3_20139965_ChIP-Seq_ESCs_Mouse1.07400815
161NANOG_16518401_ChIP-PET_MESCs_Mouse1.06350972
162* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05951743
163LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05877480
164Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04384941
165NFYA_21822215_ChIP-Seq_K562_Human1.04303489
166RUNX1_27457419_Chip-Seq_LIVER_Mouse1.02869151
167PU1_27457419_Chip-Seq_LIVER_Mouse1.01344853
168TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01342286
169ELK4_26923725_Chip-Seq_MESODERM_Mouse1.01038735

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.10867721
2MP0003880_abnormal_central_pattern3.92856561
3MP0003635_abnormal_synaptic_transmissio3.54186837
4MP0003787_abnormal_imprinting3.44976029
5MP0005464_abnormal_platelet_physiology3.26074259
6MP0002063_abnormal_learning/memory/cond3.16667179
7MP0004270_analgesia2.99949393
8MP0002102_abnormal_ear_morphology2.92340696
9MP0009745_abnormal_behavioral_response2.47600354
10MP0004147_increased_porphyrin_level2.41887651
11MP0002822_catalepsy2.30367203
12MP0001968_abnormal_touch/_nociception2.20689500
13MP0002572_abnormal_emotion/affect_behav2.20466386
14MP0003195_calcinosis2.15786279
15MP0003724_increased_susceptibility_to2.09938453
16MP0009053_abnormal_anal_canal2.08241055
17MP0002837_dystrophic_cardiac_calcinosis2.04660072
18MP0002234_abnormal_pharynx_morphology1.99566421
19MP0006054_spinal_hemorrhage1.96686089
20MP0000778_abnormal_nervous_system1.96628477
21MP0002064_seizures1.94054092
22MP0001188_hyperpigmentation1.91123978
23MP0004885_abnormal_endolymph1.90287006
24MP0008004_abnormal_stomach_pH1.90278212
25MP0000647_abnormal_sebaceous_gland1.90220730
26MP0005394_taste/olfaction_phenotype1.86040693
27MP0005499_abnormal_olfactory_system1.86040693
28MP0005084_abnormal_gallbladder_morpholo1.84702855
29MP0002736_abnormal_nociception_after1.83767647
30MP0004084_abnormal_cardiac_muscle1.78936405
31MP0002909_abnormal_adrenal_gland1.78461029
32MP0000465_gastrointestinal_hemorrhage1.75257763
33MP0001984_abnormal_olfaction1.66439357
34MP0009780_abnormal_chondrocyte_physiolo1.63954808
35MP0003119_abnormal_digestive_system1.62920574
36MP0008995_early_reproductive_senescence1.62464507
37MP0003121_genomic_imprinting1.60259172
38MP0010234_abnormal_vibrissa_follicle1.59653629
39MP0000372_irregular_coat_pigmentation1.59608470
40MP0005646_abnormal_pituitary_gland1.58786608
41MP0001501_abnormal_sleep_pattern1.58184596
42MP0002090_abnormal_vision1.57053327
43MP0001486_abnormal_startle_reflex1.56246154
44MP0002184_abnormal_innervation1.52838818
45MP0004811_abnormal_neuron_physiology1.52769094
46MP0010368_abnormal_lymphatic_system1.52213471
47MP0008789_abnormal_olfactory_epithelium1.51645193
48MP0002734_abnormal_mechanical_nocicepti1.50809978
49MP0008775_abnormal_heart_ventricle1.48748785
50MP0004858_abnormal_nervous_system1.47916425
51MP0000516_abnormal_urinary_system1.41162694
52MP0005367_renal/urinary_system_phenotyp1.41162694
53MP0005248_abnormal_Harderian_gland1.39042149
54MP0010329_abnormal_lipoprotein_level1.38953781
55MP0002272_abnormal_nervous_system1.37707196
56MP0003656_abnormal_erythrocyte_physiolo1.37700697
57MP0003011_delayed_dark_adaptation1.37054662
58MP0002733_abnormal_thermal_nociception1.33911710
59MP0000569_abnormal_digit_pigmentation1.33026029
60MP0003705_abnormal_hypodermis_morpholog1.31510518
61MP0003122_maternal_imprinting1.30902145
62MP0002735_abnormal_chemical_nociception1.30240361
63MP0000955_abnormal_spinal_cord1.29924503
64MP0005187_abnormal_penis_morphology1.29327872
65MP0003221_abnormal_cardiomyocyte_apopto1.27671595
66MP0010386_abnormal_urinary_bladder1.26815948
67MP0005253_abnormal_eye_physiology1.26419413
68MP0004510_myositis1.26051733
69MP0000534_abnormal_ureter_morphology1.25081349
70MP0004924_abnormal_behavior1.23847244
71MP0005386_behavior/neurological_phenoty1.23847244
72MP0002638_abnormal_pupillary_reflex1.23449772
73MP0009046_muscle_twitch1.23171487
74MP0003890_abnormal_embryonic-extraembry1.22895752
75MP0002557_abnormal_social/conspecific_i1.21824503
76MP0003123_paternal_imprinting1.21041185
77MP0004142_abnormal_muscle_tone1.20786973
78MP0000230_abnormal_systemic_arterial1.19687770
79MP0000537_abnormal_urethra_morphology1.18188021
80MP0001440_abnormal_grooming_behavior1.17973830
81MP0002152_abnormal_brain_morphology1.14444212
82MP0003861_abnormal_nervous_system1.10881818
83MP0008877_abnormal_DNA_methylation1.08584161
84MP0009697_abnormal_copulation1.08532898
85MP0001970_abnormal_pain_threshold1.07558791
86MP0002067_abnormal_sensory_capabilities1.06899503
87MP0004233_abnormal_muscle_weight1.06679464
88MP0004484_altered_response_of1.06280309
89MP0002972_abnormal_cardiac_muscle1.05081706
90MP0000343_altered_response_to1.02427344
91MP0005551_abnormal_eye_electrophysiolog1.01388742
92MP0005636_abnormal_mineral_homeostasis0.98935371
93MP0000427_abnormal_hair_cycle0.98658869
94MP0006035_abnormal_mitochondrial_morpho0.98563689
95MP0005623_abnormal_meninges_morphology0.97186884
96MP0005535_abnormal_body_temperature0.97103577
97MP0006292_abnormal_olfactory_placode0.94431419
98MP0002882_abnormal_neuron_morphology0.92090915
99MP0001879_abnormal_lymphatic_vessel0.92079224
100MP0005409_darkened_coat_color0.91004713
101MP0002751_abnormal_autonomic_nervous0.90693392
102MP0005167_abnormal_blood-brain_barrier0.90219930
103MP0005423_abnormal_somatic_nervous0.90200950
104MP0005645_abnormal_hypothalamus_physiol0.89937237
105MP0003941_abnormal_skin_development0.89850745
106MP0003755_abnormal_palate_morphology0.89279054
107MP0002066_abnormal_motor_capabilities/c0.88276953
108MP0001756_abnormal_urination0.87981700
109MP0003329_amyloid_beta_deposits0.86893180
110MP0005410_abnormal_fertilization0.85612523
111MP0003385_abnormal_body_wall0.85378755
112MP0001529_abnormal_vocalization0.85202008
113MP0002084_abnormal_developmental_patter0.85099418
114MP0006036_abnormal_mitochondrial_physio0.83644755
115MP0004272_abnormal_basement_membrane0.83257451
116MP0003283_abnormal_digestive_organ0.83216149
117MP0005085_abnormal_gallbladder_physiolo0.82367983
118MP0003186_abnormal_redox_activity0.81851995
119MP0000383_abnormal_hair_follicle0.80047355
120MP0004085_abnormal_heartbeat0.79983274
121MP0002332_abnormal_exercise_endurance0.79340496
122MP0001177_atelectasis0.78959150
123MP0001905_abnormal_dopamine_level0.78000970
124MP0005620_abnormal_muscle_contractility0.77677371
125MP0003828_pulmonary_edema0.77471224
126MP0001727_abnormal_embryo_implantation0.77353344
127MP0000631_abnormal_neuroendocrine_gland0.76640103
128MP0009379_abnormal_foot_pigmentation0.75976327
129MP0004036_abnormal_muscle_relaxation0.75659786
130MP0008569_lethality_at_weaning0.74842060
131MP0006276_abnormal_autonomic_nervous0.73820077
132MP0002233_abnormal_nose_morphology0.73485145
133MP0002081_perinatal_lethality0.72826820
134MP0002254_reproductive_system_inflammat0.71376821
135MP0004215_abnormal_myocardial_fiber0.71349765
136MP0004133_heterotaxia0.71269029
137MP0002086_abnormal_extraembryonic_tissu0.71008557
138MP0010352_gastrointestinal_tract_polyps0.69789616
139MP0006138_congestive_heart_failure0.67936235
140MP0003879_abnormal_hair_cell0.66810589
141MP0003633_abnormal_nervous_system0.64215719
142MP0010678_abnormal_skin_adnexa0.64060503
143MP0002295_abnormal_pulmonary_circulatio0.63193781
144MP0005595_abnormal_vascular_smooth0.62167999
145MP0003942_abnormal_urinary_system0.62122881
146MP0003938_abnormal_ear_development0.61639399
147MP0002009_preneoplasia0.61364749
148MP0003045_fibrosis0.60724380
149MP0002127_abnormal_cardiovascular_syste0.59786507
150MP0003631_nervous_system_phenotype0.58950834
151MP0003935_abnormal_craniofacial_develop0.57520757

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.10001831
2Prolonged bleeding time (HP:0003010)4.63649830
3Increased mean platelet volume (HP:0011877)4.61617506
4Papillary thyroid carcinoma (HP:0002895)4.20958645
5Abnormal platelet volume (HP:0011876)4.07353997
6Myokymia (HP:0002411)4.06096675
7Menorrhagia (HP:0000132)3.97263727
8Epileptic encephalopathy (HP:0200134)3.88682262
9Focal seizures (HP:0007359)3.78952130
10Abnormality of the labia minora (HP:0012880)3.74480981
11Acanthocytosis (HP:0001927)3.60159295
12Petechiae (HP:0000967)3.59610469
13Thyroid carcinoma (HP:0002890)3.56307151
14Volvulus (HP:0002580)3.52157681
15Drooling (HP:0002307)3.26880102
16Excessive salivation (HP:0003781)3.26880102
17Poikilocytosis (HP:0004447)3.17728298
18Polyphagia (HP:0002591)3.07161279
19Curly hair (HP:0002212)2.98170194
20Visual hallucinations (HP:0002367)2.92448363
21Hyperlipoproteinemia (HP:0010980)2.91943460
223-Methylglutaconic aciduria (HP:0003535)2.91711697
23Febrile seizures (HP:0002373)2.88080128
24Papilledema (HP:0001085)2.87696300
25Gingival bleeding (HP:0000225)2.87371001
26Facial hemangioma (HP:0000329)2.81296804
27Hypothermia (HP:0002045)2.79463521
28Astrocytoma (HP:0009592)2.78056084
29Abnormality of the astrocytes (HP:0100707)2.78056084
30Birth length less than 3rd percentile (HP:0003561)2.75854474
31Ankyloglossia (HP:0010296)2.75319729
32Thyroid-stimulating hormone excess (HP:0002925)2.75186182
33Upper limb muscle weakness (HP:0003484)2.74570907
34Ependymoma (HP:0002888)2.74146155
35Amblyopia (HP:0000646)2.73316319
36Atonic seizures (HP:0010819)2.72342947
37Hyperventilation (HP:0002883)2.71771691
38Cortical dysplasia (HP:0002539)2.71591711
39Absence seizures (HP:0002121)2.71037501
40Absent eyebrow (HP:0002223)2.59719810
41Shawl scrotum (HP:0000049)2.58926873
42Abnormality of the lower motor neuron (HP:0002366)2.55040754
43Epistaxis (HP:0000421)2.54075396
44Progressive cerebellar ataxia (HP:0002073)2.52879668
45Medial flaring of the eyebrow (HP:0010747)2.49559202
46Abnormality of the heme biosynthetic pathway (HP:0010472)2.49012636
47Gait imbalance (HP:0002141)2.47951705
48Abnormality of cochlea (HP:0000375)2.41836099
49Congenital primary aphakia (HP:0007707)2.41457817
50Nephrogenic diabetes insipidus (HP:0009806)2.41166441
51Hypomagnesemia (HP:0002917)2.40358682
52Impaired smooth pursuit (HP:0007772)2.39399475
53Purpura (HP:0000979)2.38695052
54Generalized tonic-clonic seizures (HP:0002069)2.38390042
55Dialeptic seizures (HP:0011146)2.37039482
56Abnormality of binocular vision (HP:0011514)2.34508780
57Diplopia (HP:0000651)2.34508780
58Genital tract atresia (HP:0001827)2.33543516
59Dyschromatopsia (HP:0007641)2.30071189
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.27083585
61Degeneration of the lateral corticospinal tracts (HP:0002314)2.27083585
62Hydroureter (HP:0000072)2.26398986
63Broad-based gait (HP:0002136)2.25464408
64Gastroesophageal reflux (HP:0002020)2.21240312
65Poor eye contact (HP:0000817)2.19250392
66Annular pancreas (HP:0001734)2.19203145
67Insidious onset (HP:0003587)2.18274522
68Termporal pattern (HP:0011008)2.18274522
69Abnormal hair whorl (HP:0010721)2.16474107
70Epileptiform EEG discharges (HP:0011182)2.14918522
71Urethral obstruction (HP:0000796)2.14001000
72Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.12935716
73Agitation (HP:0000713)2.12897410
74Hypochromic microcytic anemia (HP:0004840)2.11122726
75Spontaneous hematomas (HP:0007420)2.10512824
76Oligodactyly (hands) (HP:0001180)2.10224405
77Vaginal atresia (HP:0000148)2.09855378
78Abnormality of salivation (HP:0100755)2.09743757
79Pointed chin (HP:0000307)2.09657075
80Inappropriate behavior (HP:0000719)2.09426896
81Impaired vibration sensation in the lower limbs (HP:0002166)2.07843007
82Abnormality of oral frenula (HP:0000190)2.07149998
83Morphological abnormality of the inner ear (HP:0011390)2.06439789
84Labial hypoplasia (HP:0000066)2.05909377
85Amyotrophic lateral sclerosis (HP:0007354)2.05822330
86Biliary tract neoplasm (HP:0100574)2.05366025
87Glioma (HP:0009733)2.04564933
88Abdominal situs inversus (HP:0003363)2.02007550
89Abnormality of abdominal situs (HP:0011620)2.02007550
90Tongue fasciculations (HP:0001308)2.01142671
91Neoplasm of the oral cavity (HP:0100649)2.00034390
92Shoulder girdle muscle weakness (HP:0003547)1.99344662
93Hypoglycemic coma (HP:0001325)1.99305814
94Delayed puberty (HP:0000823)1.99151276
95Aplasia/Hypoplasia of the sternum (HP:0006714)1.99052890
96Pili torti (HP:0003777)1.98753443
97Intestinal atresia (HP:0011100)1.97680633
98Action tremor (HP:0002345)1.96787453
99Hepatoblastoma (HP:0002884)1.96521000
100Bladder neoplasm (HP:0009725)1.92693201
101Bladder carcinoma (HP:0002862)1.92693201
102Renal cortical cysts (HP:0000803)1.92212372
103Hypoplastic labia majora (HP:0000059)1.91332898
104Supernumerary spleens (HP:0009799)1.91101295
105Transitional cell carcinoma of the bladder (HP:0006740)1.90833474
106Split foot (HP:0001839)1.90422841
107Lissencephaly (HP:0001339)1.90291528
108Cutaneous finger syndactyly (HP:0010554)1.90201917
109EEG with generalized epileptiform discharges (HP:0011198)1.89533526
110Hypoplastic female external genitalia (HP:0012815)1.88708720
111Stereotypic behavior (HP:0000733)1.88150816
112Pachygyria (HP:0001302)1.88098488
113Increased number of teeth (HP:0011069)1.87815100
114Protruding tongue (HP:0010808)1.87638356
115Shallow orbits (HP:0000586)1.87067255
116Breast hypoplasia (HP:0003187)1.87012294
117Genetic anticipation (HP:0003743)1.86773089
118Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.86420463
119Impaired social interactions (HP:0000735)1.86018359
120Abnormal social behavior (HP:0012433)1.86018359
121Limb dystonia (HP:0002451)1.85317045
122Capillary hemangiomas (HP:0005306)1.84528401
123Abnormality of ocular smooth pursuit (HP:0000617)1.83983055
124Widely spaced teeth (HP:0000687)1.83431673
125Abnormality of lateral ventricle (HP:0030047)1.83413164
126Hemiparesis (HP:0001269)1.82809540
127Ankle clonus (HP:0011448)1.82787508
128Delusions (HP:0000746)1.82703290
129Absent speech (HP:0001344)1.82096735
130Impaired platelet aggregation (HP:0003540)1.81827643
131Abnormal platelet function (HP:0011869)1.81827643
132Muscle fibrillation (HP:0010546)1.81701853
133Orthostatic hypotension (HP:0001278)1.80769970
134Generalized myoclonic seizures (HP:0002123)1.80683445
135Obstructive sleep apnea (HP:0002870)1.80607421
136Increased density of long bones (HP:0006392)1.80360128
137Abnormal auditory evoked potentials (HP:0006958)1.80358472
138Poor coordination (HP:0002370)1.80177836
139Decreased testicular size (HP:0008734)1.79981014
140Pelvic girdle muscle weakness (HP:0003749)1.79380408
141Specific learning disability (HP:0001328)1.77831995
142Hypsarrhythmia (HP:0002521)1.75445978
143Bundle branch block (HP:0011710)1.75312686
144Neonatal hypoglycemia (HP:0001998)1.75282833
145Truncal ataxia (HP:0002078)1.75278114
146Abnormality of the labia (HP:0000058)1.74332135
147Conjunctival telangiectasia (HP:0000524)1.72760292
148Abnormality of the corticospinal tract (HP:0002492)1.71653598
149Abnormality of the labia majora (HP:0012881)1.71500435
150Tented upper lip vermilion (HP:0010804)1.71431322
151Neuroendocrine neoplasm (HP:0100634)1.71141423
152Pheochromocytoma (HP:0002666)1.71119878
153Abnormality of the vasculature of the conjunctiva (HP:0008054)1.69998993
154Bronchomalacia (HP:0002780)1.69769459
155Abnormality of the antihelix (HP:0009738)1.69626699
156Atrioventricular canal defect (HP:0006695)1.69320680
157Wrist flexion contracture (HP:0001239)1.67906555
158Dysdiadochokinesis (HP:0002075)1.66963945
159Abnormal eating behavior (HP:0100738)1.66410097
160Spastic tetraplegia (HP:0002510)1.66337113
161Exotropia (HP:0000577)1.65840729
162Aqueductal stenosis (HP:0002410)1.64849240
163Abnormality of magnesium homeostasis (HP:0004921)1.64243267
164Pancreatic islet-cell hyperplasia (HP:0004510)1.63899843
165Failure to thrive in infancy (HP:0001531)1.63391071
166Heterochromia iridis (HP:0001100)1.63186612
167Retinal atrophy (HP:0001105)1.63046851
168Atrioventricular block (HP:0001678)1.62657559
169Oligodactyly (HP:0012165)1.62554918
170Spastic gait (HP:0002064)1.62062913
171Absent hair (HP:0002298)1.61855042
172Urinary urgency (HP:0000012)1.61717000
173Muscular hypotonia of the trunk (HP:0008936)1.61663210
174Abnormality of alanine metabolism (HP:0010916)1.61207471
175Hyperalaninemia (HP:0003348)1.61207471
176Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.61207471
177Abnormal biliary tract morphology (HP:0012440)1.61029531
178Arterial tortuosity (HP:0005116)1.61017125
179Neoplasm of the thyroid gland (HP:0100031)1.60948067
180Short chin (HP:0000331)1.60173084
181Horizontal nystagmus (HP:0000666)1.58343132
182Abnormality of the hip-girdle musculature (HP:0001445)1.57255926
183Abnormality of the musculature of the pelvis (HP:0001469)1.57255926
184Thickened helices (HP:0000391)1.57061615
185Urinary bladder sphincter dysfunction (HP:0002839)1.55864346
186Short 4th metacarpal (HP:0010044)1.55810881

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.33319572
2NTRK34.15266944
3MARK13.94927317
4TRIM283.47166464
5MAP4K23.33389578
6MAP3K92.94478178
7MST42.84966975
8LATS22.66970449
9MAP3K42.55287808
10MINK12.42826579
11DAPK12.41718376
12DAPK22.39570215
13KSR12.17233893
14MAP3K121.99479103
15MAP2K71.99011093
16AKT31.87820679
17PAK61.80668836
18ADRBK21.75761502
19PLK21.75252014
20ACVR1B1.73796889
21PNCK1.72661490
22KSR21.71842330
23MAP2K41.71007388
24NTRK21.70738992
25RIPK41.67234289
26SIK31.66099134
27EIF2AK11.54666217
28EPHA31.51433458
29STK31.45153527
30MAP3K21.44081603
31MAPK131.37364107
32MAP3K61.36966769
33MAP3K51.36456907
34CASK1.36301328
35DYRK31.30935731
36EPHA21.30927339
37PINK11.30410964
38NEK11.28320096
39TNIK1.27551842
40TIE11.22856190
41PTK2B1.22173895
42MYLK1.21982961
43GRK11.20619608
44FER1.17120574
45BMPR1B1.17066080
46CSNK1G31.16433176
47CDK51.15018609
48PRKCG1.11606965
49CSNK1G11.08549570
50DDR21.04747371
51PRPF4B1.01069299
52STK38L0.99260579
53GRK50.95621365
54RAF10.95254551
55YES10.94266921
56ERBB30.91667900
57KDR0.91038160
58CSNK1A1L0.90898007
59PLK30.90837768
60CAMKK10.89158162
61EPHB20.87692012
62STK380.86283337
63CDC70.86156455
64NTRK10.84531754
65BMX0.84347197
66CAMKK20.83726600
67PDGFRA0.80847631
68TSSK60.80622668
69LATS10.80560687
70CAMK2A0.80144743
71TAOK20.79949414
72SRPK10.79579411
73PRKD30.78959912
74ALK0.77647883
75TGFBR10.74573230
76OXSR10.74440287
77FGR0.73992681
78INSRR0.73347578
79PIK3CG0.73200273
80CDK140.72393094
81TEC0.72266477
82RPS6KA40.71512710
83CDK180.71025354
84SGK20.69955659
85NME20.68848391
86EIF2AK30.68595711
87BRD40.68254939
88BRSK20.65901692
89CDK150.65353437
90TYRO30.63863908
91RET0.63847608
92CAMK2B0.62893159
93WNK30.60547876
94GRK70.60307787
95BMPR20.60093695
96SGK10.58913430
97RIPK10.57688750
98WEE10.57477380
99TAOK30.57115048
100SIK20.56322233
101TAOK10.56186009
102PAK40.55904653
103FRK0.55719816
104DYRK1A0.55045902
105FGFR10.54718274
106CDK11A0.53892012
107DYRK1B0.53168278
108NUAK10.51695688
109STK240.51462245
110MAPK100.51228409
111DYRK20.50749894
112CSNK1G20.49788477
113PAK30.48767296
114SGK30.48588551
115PIM20.48189896
116FGFR20.46897372
117CDK30.45635443
118ERBB20.45501270
119CDK60.44878572
120PRKG10.44466176
121NEK60.44380998
122PDK20.43564833
123LMTK20.43393626
124FES0.42233219
125RPS6KA30.41141286
126PRKACG0.40494560
127CCNB10.39981602
128PRKCE0.39570712
129CSNK1E0.39240285
130PHKG10.36853458
131PHKG20.36853458
132IRAK10.36845240
133MAP2K10.36570593
134PRKD10.35810307
135BCR0.34891408
136ERBB40.34458304
137JAK20.34065448
138PRKACB0.33124535
139STK160.32725146
140ADRBK10.31257991
141CHEK20.30936747
142SGK2230.30731536
143SGK4940.30731536
144STK40.30623292
145PRKCZ0.29946052
146MAPK120.29830815
147UHMK10.28843690
148FYN0.28447108
149MAPK90.28310281
150CDK20.27429012
151DAPK30.25972552

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.64204976
2Long-term potentiation_Homo sapiens_hsa047203.05227935
3Steroid biosynthesis_Homo sapiens_hsa001002.95929841
4Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.60685406
5Circadian entrainment_Homo sapiens_hsa047132.58338820
6Amphetamine addiction_Homo sapiens_hsa050312.54284817
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.51837166
8Protein export_Homo sapiens_hsa030602.38734901
9Glutamatergic synapse_Homo sapiens_hsa047242.35403775
10GABAergic synapse_Homo sapiens_hsa047272.17846219
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.10492496
12Dopaminergic synapse_Homo sapiens_hsa047282.07348113
13Synaptic vesicle cycle_Homo sapiens_hsa047212.03975559
14Salivary secretion_Homo sapiens_hsa049702.03355467
15Morphine addiction_Homo sapiens_hsa050322.01734358
16Olfactory transduction_Homo sapiens_hsa047401.96950263
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.93971621
18Renin secretion_Homo sapiens_hsa049241.91138334
19Butanoate metabolism_Homo sapiens_hsa006501.88953602
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.77448595
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.74276936
22Oxytocin signaling pathway_Homo sapiens_hsa049211.72811368
23Long-term depression_Homo sapiens_hsa047301.72738026
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.71759082
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71546954
26Fatty acid elongation_Homo sapiens_hsa000621.70972326
27Vibrio cholerae infection_Homo sapiens_hsa051101.70505852
28Platelet activation_Homo sapiens_hsa046111.70197803
29Cholinergic synapse_Homo sapiens_hsa047251.63377807
30Taste transduction_Homo sapiens_hsa047421.60745486
31Gap junction_Homo sapiens_hsa045401.59462334
32Insulin secretion_Homo sapiens_hsa049111.58173322
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.51838142
34Axon guidance_Homo sapiens_hsa043601.48931241
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48914779
36GnRH signaling pathway_Homo sapiens_hsa049121.46108308
37Glioma_Homo sapiens_hsa052141.45346691
38Gastric acid secretion_Homo sapiens_hsa049711.44033739
39Oocyte meiosis_Homo sapiens_hsa041141.43048613
40Estrogen signaling pathway_Homo sapiens_hsa049151.40998528
41Calcium signaling pathway_Homo sapiens_hsa040201.39810916
42Serotonergic synapse_Homo sapiens_hsa047261.39752352
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.37942392
44Melanogenesis_Homo sapiens_hsa049161.36634768
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33570508
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.24613207
47Rap1 signaling pathway_Homo sapiens_hsa040151.21331416
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20789089
49cAMP signaling pathway_Homo sapiens_hsa040241.19835217
50Basal transcription factors_Homo sapiens_hsa030221.19507420
51mTOR signaling pathway_Homo sapiens_hsa041501.18923203
52Cocaine addiction_Homo sapiens_hsa050301.17395229
53Oxidative phosphorylation_Homo sapiens_hsa001901.16339289
54Choline metabolism in cancer_Homo sapiens_hsa052311.15668961
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14743387
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12344799
57ErbB signaling pathway_Homo sapiens_hsa040121.11381948
58Primary bile acid biosynthesis_Homo sapiens_hsa001201.10710068
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06582646
60Colorectal cancer_Homo sapiens_hsa052101.05893367
61VEGF signaling pathway_Homo sapiens_hsa043701.04925519
62Regulation of autophagy_Homo sapiens_hsa041400.97245271
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96763408
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.96433971
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95097122
66Wnt signaling pathway_Homo sapiens_hsa043100.92908222
67Hippo signaling pathway_Homo sapiens_hsa043900.92504204
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92174101
69Collecting duct acid secretion_Homo sapiens_hsa049660.92080397
70Ras signaling pathway_Homo sapiens_hsa040140.91872354
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91020145
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90524769
73Phototransduction_Homo sapiens_hsa047440.88784363
74Type II diabetes mellitus_Homo sapiens_hsa049300.88715580
75Adherens junction_Homo sapiens_hsa045200.88348197
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.85416868
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83667775
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82812469
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82322908
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81409064
81Glucagon signaling pathway_Homo sapiens_hsa049220.80689535
82Parkinsons disease_Homo sapiens_hsa050120.80075197
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.78865226
84Non-small cell lung cancer_Homo sapiens_hsa052230.77478363
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77431476
86Circadian rhythm_Homo sapiens_hsa047100.77398650
87Dorso-ventral axis formation_Homo sapiens_hsa043200.77149827
88Endometrial cancer_Homo sapiens_hsa052130.75424977
89TGF-beta signaling pathway_Homo sapiens_hsa043500.74109484
90Sulfur metabolism_Homo sapiens_hsa009200.73118602
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72026807
92MAPK signaling pathway_Homo sapiens_hsa040100.71917406
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71719648
94Propanoate metabolism_Homo sapiens_hsa006400.70848030
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70223792
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69117278
97Ether lipid metabolism_Homo sapiens_hsa005650.68563132
98Melanoma_Homo sapiens_hsa052180.68162311
99Selenocompound metabolism_Homo sapiens_hsa004500.67521519
100Phagosome_Homo sapiens_hsa041450.66316331
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64361860
102Focal adhesion_Homo sapiens_hsa045100.62826639
103Peroxisome_Homo sapiens_hsa041460.62174768
104Nitrogen metabolism_Homo sapiens_hsa009100.62095274
105Alcoholism_Homo sapiens_hsa050340.61226520
106Shigellosis_Homo sapiens_hsa051310.60618894
107MicroRNAs in cancer_Homo sapiens_hsa052060.60605813
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60602566
109Dilated cardiomyopathy_Homo sapiens_hsa054140.60552487
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60359756
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59594939
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58205138
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.57572830
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57340327
115African trypanosomiasis_Homo sapiens_hsa051430.57297844
116Thyroid hormone synthesis_Homo sapiens_hsa049180.57238268
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.56854284
118Proteoglycans in cancer_Homo sapiens_hsa052050.55772525
119Tight junction_Homo sapiens_hsa045300.54592123
120Linoleic acid metabolism_Homo sapiens_hsa005910.53499397
121Renal cell carcinoma_Homo sapiens_hsa052110.52735410
122Pancreatic secretion_Homo sapiens_hsa049720.52370353
123Basal cell carcinoma_Homo sapiens_hsa052170.51236711
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51015777
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48865900
126Bladder cancer_Homo sapiens_hsa052190.47901881
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46873988
128Hedgehog signaling pathway_Homo sapiens_hsa043400.46308076
129AMPK signaling pathway_Homo sapiens_hsa041520.46271462
130Fatty acid biosynthesis_Homo sapiens_hsa000610.46166895
131RNA transport_Homo sapiens_hsa030130.44385208
132Inositol phosphate metabolism_Homo sapiens_hsa005620.43844831
133FoxO signaling pathway_Homo sapiens_hsa040680.43445442
134Fat digestion and absorption_Homo sapiens_hsa049750.43243623
135Fatty acid metabolism_Homo sapiens_hsa012120.43107165
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.43035226
137mRNA surveillance pathway_Homo sapiens_hsa030150.42957037
138Sphingolipid metabolism_Homo sapiens_hsa006000.42123656
139Insulin signaling pathway_Homo sapiens_hsa049100.41651853
140Pathways in cancer_Homo sapiens_hsa052000.41452772
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41137544
142Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41082125
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40300361
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39935884
145beta-Alanine metabolism_Homo sapiens_hsa004100.38973076
146Legionellosis_Homo sapiens_hsa051340.36661092
147ABC transporters_Homo sapiens_hsa020100.35699392
148Steroid hormone biosynthesis_Homo sapiens_hsa001400.35445706
149Chemokine signaling pathway_Homo sapiens_hsa040620.32025375
150Alzheimers disease_Homo sapiens_hsa050100.31787431
151Cardiac muscle contraction_Homo sapiens_hsa042600.31622056
152Glutathione metabolism_Homo sapiens_hsa004800.30804011

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