ARL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.25993548
2axon ensheathment in central nervous system (GO:0032291)9.25993548
3fatty acid elongation (GO:0030497)6.51463197
4ensheathment of neurons (GO:0007272)5.51542022
5axon ensheathment (GO:0008366)5.51542022
6myelination (GO:0042552)5.51454149
7long-chain fatty acid biosynthetic process (GO:0042759)5.45063495
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.34713667
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.33351737
10protein maturation by protein folding (GO:0022417)5.24928570
11ATP synthesis coupled proton transport (GO:0015986)5.12532028
12energy coupled proton transport, down electrochemical gradient (GO:0015985)5.12532028
13regulation of mitochondrial translation (GO:0070129)4.91666784
14establishment of integrated proviral latency (GO:0075713)4.79371935
15deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.77037907
16protein neddylation (GO:0045116)4.62795022
17respiratory electron transport chain (GO:0022904)4.40051926
18substantia nigra development (GO:0021762)4.36373001
19chaperone-mediated protein transport (GO:0072321)4.33155358
20ribosomal small subunit assembly (GO:0000028)4.32558109
21electron transport chain (GO:0022900)4.28300754
22establishment of mitochondrion localization (GO:0051654)4.22796930
23establishment of viral latency (GO:0019043)4.22196580
24proteasome assembly (GO:0043248)4.22190766
25cholesterol biosynthetic process (GO:0006695)4.11529030
26negative regulation of neurotransmitter transport (GO:0051589)4.04729900
27negative regulation of neurotransmitter secretion (GO:0046929)4.01286822
28pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.99956605
29protein targeting to mitochondrion (GO:0006626)3.97483753
30termination of RNA polymerase III transcription (GO:0006386)3.96329947
31transcription elongation from RNA polymerase III promoter (GO:0006385)3.96329947
32presynaptic membrane organization (GO:0097090)3.80320389
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.80096483
34establishment of protein localization to mitochondrion (GO:0072655)3.79161719
35oxidative phosphorylation (GO:0006119)3.75421108
36oligodendrocyte differentiation (GO:0048709)3.73491508
37respiratory chain complex IV assembly (GO:0008535)3.68768065
38cytochrome complex assembly (GO:0017004)3.66427011
39presynaptic membrane assembly (GO:0097105)3.64891478
40viral transcription (GO:0019083)3.64760903
41sterol biosynthetic process (GO:0016126)3.64709361
42negative regulation of protein localization to cell surface (GO:2000009)3.62710862
43regulation of collateral sprouting (GO:0048670)3.57936173
44protein localization to mitochondrion (GO:0070585)3.56926537
45telomere maintenance via semi-conservative replication (GO:0032201)3.56740106
46response to redox state (GO:0051775)3.56644495
47myelin maintenance (GO:0043217)3.54810535
48cullin deneddylation (GO:0010388)3.53936319
49translational termination (GO:0006415)3.50626544
50negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.47761562
51negative regulation of ligase activity (GO:0051352)3.47761562
52ribosomal small subunit biogenesis (GO:0042274)3.46646177
53DNA strand elongation involved in DNA replication (GO:0006271)3.45822018
54protein deneddylation (GO:0000338)3.44727949
55neuron cell-cell adhesion (GO:0007158)3.44346975
56pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.43940649
57creatine metabolic process (GO:0006600)3.43790893
58regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.42449758
59pseudouridine synthesis (GO:0001522)3.42084003
60glycerophospholipid catabolic process (GO:0046475)3.40676637
61base-excision repair, AP site formation (GO:0006285)3.39794628
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.39488122
63rRNA modification (GO:0000154)3.38985146
64SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.36724777
65astrocyte development (GO:0014002)3.35446727
66neuronal action potential propagation (GO:0019227)3.35302056
67isoprenoid biosynthetic process (GO:0008299)3.34157930
68maturation of SSU-rRNA (GO:0030490)3.33634654
69regulation of cellular amino acid metabolic process (GO:0006521)3.32859213
70cotranslational protein targeting to membrane (GO:0006613)3.31809835
71mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.31629378
72protein targeting to ER (GO:0045047)3.29616112
73GTP biosynthetic process (GO:0006183)3.28566042
74apical protein localization (GO:0045176)3.27801626
75DNA strand elongation (GO:0022616)3.27631489
76translational elongation (GO:0006414)3.26445554
77mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.26111788
78mitochondrial respiratory chain complex I assembly (GO:0032981)3.26111788
79NADH dehydrogenase complex assembly (GO:0010257)3.26111788
80neurotransmitter uptake (GO:0001504)3.25303897
81guanosine-containing compound biosynthetic process (GO:1901070)3.23072018
82anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.22701154
83tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.21326388
84RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.21326388
85pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.20933217
86protein localization to endoplasmic reticulum (GO:0070972)3.20083394
87ribosomal large subunit biogenesis (GO:0042273)3.19744950
88negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.18746984
89protein complex biogenesis (GO:0070271)3.18701191
90nuclear envelope reassembly (GO:0031468)3.18250464
91mitotic nuclear envelope reassembly (GO:0007084)3.18250464
92positive regulation of action potential (GO:0045760)3.17791463
93metallo-sulfur cluster assembly (GO:0031163)3.17319195
94iron-sulfur cluster assembly (GO:0016226)3.17319195
95pyrimidine nucleotide catabolic process (GO:0006244)3.16435827
96pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.15486529
97translation (GO:0006412)3.15180474
98ribonucleoside triphosphate biosynthetic process (GO:0009201)3.15173191
99establishment of protein localization to endoplasmic reticulum (GO:0072599)3.13540989
100virion attachment to host cell (GO:0019062)3.13001873
101adhesion of symbiont to host cell (GO:0044650)3.13001873
102cellular component biogenesis (GO:0044085)3.11847783
103deoxyribonucleotide catabolic process (GO:0009264)3.11279940
104DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.09350615
105GPI anchor biosynthetic process (GO:0006506)3.08264456
106negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.07825521
107neural nucleus development (GO:0048857)3.07168031
108aerobic respiration (GO:0009060)3.06866615
109UTP biosynthetic process (GO:0006228)3.06804490
110L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.06239097
111adult walking behavior (GO:0007628)3.04867535
112amyloid precursor protein metabolic process (GO:0042982)3.04321689
113signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.03651232
114signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.03651232
115signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.03651232
116long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.03316828
117transmission of nerve impulse (GO:0019226)3.02957151
118spliceosomal snRNP assembly (GO:0000387)3.02903013
119mannosylation (GO:0097502)3.02444546
120regulation of catecholamine metabolic process (GO:0042069)3.02213544
121regulation of dopamine metabolic process (GO:0042053)3.02213544
122transcription-coupled nucleotide-excision repair (GO:0006283)3.01415107
123deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.00706733
124purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.00050929
125purine nucleoside monophosphate biosynthetic process (GO:0009127)3.00050929
126signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.99822875
127intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.99822875
128positive regulation of oligodendrocyte differentiation (GO:0048714)2.99573791
129nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99260462
130mitochondrial transport (GO:0006839)2.99141995
131positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.98273797
132long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.97280456
1332-deoxyribonucleotide biosynthetic process (GO:0009265)2.97033372
134deoxyribose phosphate biosynthetic process (GO:0046385)2.97033372
135nucleoside triphosphate biosynthetic process (GO:0009142)2.94953525
136signal transduction involved in DNA integrity checkpoint (GO:0072401)2.93507814
137signal transduction involved in DNA damage checkpoint (GO:0072422)2.93507814
138cellular response to epinephrine stimulus (GO:0071872)2.92457570
139establishment of protein localization to mitochondrial membrane (GO:0090151)2.92444090
140exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90521320
141deoxyribose phosphate catabolic process (GO:0046386)2.90490060
142peptidyl-cysteine modification (GO:0018198)2.89946801
143hydrogen ion transmembrane transport (GO:1902600)2.89517244
144photoreceptor cell differentiation (GO:0046530)2.88252131
145eye photoreceptor cell differentiation (GO:0001754)2.88252131
146asymmetric protein localization (GO:0008105)2.85280657
147protein palmitoylation (GO:0018345)2.81059728
148GPI anchor metabolic process (GO:0006505)2.80070400
149mitochondrial respiratory chain complex assembly (GO:0033108)2.79173114
150negative regulation of axonogenesis (GO:0050771)2.78744323
151energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.74929346
152ATP hydrolysis coupled proton transport (GO:0015991)2.74929346
153peripheral nervous system axon ensheathment (GO:0032292)2.73554088
154myelination in peripheral nervous system (GO:0022011)2.73554088
155ATP biosynthetic process (GO:0006754)2.70527366
156response to epinephrine (GO:0071871)2.69807624
157negative regulation of JUN kinase activity (GO:0043508)2.68465527
158detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.67937678
159detection of temperature stimulus involved in sensory perception (GO:0050961)2.67937678
160proton transport (GO:0015992)2.67690380
161peptidyl-tyrosine autophosphorylation (GO:0038083)2.62917362
162glial cell development (GO:0021782)2.62096225
163hydrogen transport (GO:0006818)2.60639756
164neuronal ion channel clustering (GO:0045161)2.59368533
165fatty-acyl-CoA metabolic process (GO:0035337)2.58525841
166response to methylmercury (GO:0051597)2.58429251
167regulation of feeding behavior (GO:0060259)2.55107285
168dopamine biosynthetic process (GO:0042416)2.53903761
169synaptic vesicle exocytosis (GO:0016079)2.52528135
170purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.51006748
171magnesium ion transport (GO:0015693)2.50502810
172preassembly of GPI anchor in ER membrane (GO:0016254)2.49332805
173fatty-acyl-CoA biosynthetic process (GO:0046949)2.47299145
174L-amino acid import (GO:0043092)2.46239269
175membrane tubulation (GO:0097320)2.45395640
176calcium-mediated signaling using intracellular calcium source (GO:0035584)2.45258203
177purine nucleoside triphosphate biosynthetic process (GO:0009145)2.44952222
178peripheral nervous system development (GO:0007422)2.44474275
179axon development (GO:0061564)2.42982612
180microtubule polymerization or depolymerization (GO:0031109)2.38979752
181inner mitochondrial membrane organization (GO:0007007)2.38013080
182cranial nerve development (GO:0021545)2.36489530

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.06817989
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.85195897
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.83695332
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.50227888
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.37181519
6* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.17564319
7EZH2_22144423_ChIP-Seq_EOC_Human3.14508691
8GBX2_23144817_ChIP-Seq_PC3_Human3.12367691
9E2F7_22180533_ChIP-Seq_HELA_Human3.03066974
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.96642894
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.57346796
12TAF15_26573619_Chip-Seq_HEK293_Human2.52072590
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45357036
14E2F1_18555785_ChIP-Seq_MESCs_Mouse2.44548033
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.38415260
16XRN2_22483619_ChIP-Seq_HELA_Human2.34418261
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.28034747
18SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.26445786
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.25955524
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.24207666
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16134869
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08882183
23GABP_19822575_ChIP-Seq_HepG2_Human2.07127785
24DCP1A_22483619_ChIP-Seq_HELA_Human2.03904259
25TTF2_22483619_ChIP-Seq_HELA_Human2.03429656
26FOXP3_21729870_ChIP-Seq_TREG_Human1.99480391
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99240020
28CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.97638761
29NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95713252
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.95084427
31* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.93773748
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.90945487
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90759488
34VDR_23849224_ChIP-Seq_CD4+_Human1.90736063
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.89187717
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.88054804
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.88054804
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.87681598
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85879110
40VDR_22108803_ChIP-Seq_LS180_Human1.84432732
41* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82891868
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.79390753
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78744052
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77703283
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76573119
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76461924
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75226857
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.74270396
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.72907818
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.72780184
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.72118744
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68111056
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66878064
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65603499
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65501086
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59671723
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58076744
58EST1_17652178_ChIP-ChIP_JURKAT_Human1.56426398
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54665722
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.52469317
61* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.51563842
62ER_23166858_ChIP-Seq_MCF-7_Human1.51532855
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.51446696
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50786206
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.49826509
66JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48829740
67DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.48747211
68REST_21632747_ChIP-Seq_MESCs_Mouse1.47849896
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47134989
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45762490
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.44789186
72* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42445718
73RNF2_27304074_Chip-Seq_ESCs_Mouse1.42296409
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.41523294
75FUS_26573619_Chip-Seq_HEK293_Human1.41424654
76CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.38599007
77FOXP1_21924763_ChIP-Seq_HESCs_Human1.38526610
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37837225
79* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37709605
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37074742
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.36337462
82CREB1_15753290_ChIP-ChIP_HEK293T_Human1.36245001
83* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.35695258
84MYC_18940864_ChIP-ChIP_HL60_Human1.35151280
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35004033
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34389674
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30654397
88CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30292898
89* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30238347
90ETS1_20019798_ChIP-Seq_JURKAT_Human1.28744493
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28669663
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28175436
93ELK1_19687146_ChIP-ChIP_HELA_Human1.27813200
94RARB_27405468_Chip-Seq_BRAIN_Mouse1.27392593
95* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25161324
96* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24513885
97TET1_21451524_ChIP-Seq_MESCs_Mouse1.24428961
98EOMES_21245162_ChIP-Seq_HESCs_Human1.21350210
99KDM5A_27292631_Chip-Seq_BREAST_Human1.20378096
100WT1_19549856_ChIP-ChIP_CCG9911_Human1.17650641
101RNF2_27304074_Chip-Seq_NSC_Mouse1.16404337
102SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16327177
103PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14452333
104CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14073846
105RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13869006
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13805517
107CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13783087
108ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12834081
109SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12706735
110POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11947279
111EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11896422
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11123681
113P300_19829295_ChIP-Seq_ESCs_Human1.09584617
114SMAD3_21741376_ChIP-Seq_EPCs_Human1.07703169
115SRF_21415370_ChIP-Seq_HL-1_Mouse1.07555684
116ZNF263_19887448_ChIP-Seq_K562_Human1.05972571
117STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05456586
118TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04736522
119* ELF1_20517297_ChIP-Seq_JURKAT_Human1.04608654
120* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03385289
121DROSHA_22980978_ChIP-Seq_HELA_Human1.02633422
122ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02541172
123* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02235268
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01690024
125SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.01360056
126ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01188455
127CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00842477
128GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00054270
129YY1_22570637_ChIP-Seq_MALME-3M_Human0.99945810
130RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99586496
131GATA1_26923725_Chip-Seq_HPCs_Mouse0.98053398
132GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97666620
133SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97248257
134IRF1_19129219_ChIP-ChIP_H3396_Human0.96306503
135E2F1_21310950_ChIP-Seq_MCF-7_Human0.96144667
136TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95990324
137OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95937280
138CTCF_26484167_Chip-Seq_Bcells_Mouse0.93971540
139KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93719017
140* P68_20966046_ChIP-Seq_HELA_Human0.92797682
141BCL6_27268052_Chip-Seq_Bcells_Human0.92600554
142YY1_21170310_ChIP-Seq_MESCs_Mouse0.92505275
143SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91782248
144SOX2_16153702_ChIP-ChIP_HESCs_Human0.90887297
145STAT1_20625510_ChIP-Seq_HELA_Human0.89570211
146MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89536235
147POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89377797
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89017092
149AR_21572438_ChIP-Seq_LNCaP_Human0.88879048
150ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88528494
151TAL1_26923725_Chip-Seq_HPCs_Mouse0.88494516
152ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88345012
153CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88177263
154NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88061633
155* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87964232
156SOX2_19829295_ChIP-Seq_ESCs_Human0.87226435
157NANOG_19829295_ChIP-Seq_ESCs_Human0.87226435
158PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87203449
159CIITA_25753668_ChIP-Seq_RAJI_Human0.86005181
160PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85529560
161RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85513583
162ELK1_22589737_ChIP-Seq_MCF10A_Human0.84747775
163* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83649049
164HTT_18923047_ChIP-ChIP_STHdh_Human0.83447309
165CTCF_20526341_ChIP-Seq_ESCs_Human0.83212251
166VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82489715
167SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82282101
168ERG_21242973_ChIP-ChIP_JURKAT_Human0.82047860
169SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.81386702
170PIAS1_25552417_ChIP-Seq_VCAP_Human0.81099633
171CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80860695
172ZNF274_21170338_ChIP-Seq_K562_Hela0.80463152
173FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.80282461
174MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.78225723
175P53_22127205_ChIP-Seq_FIBROBLAST_Human0.78220687
176EP300_21415370_ChIP-Seq_HL-1_Mouse0.78032777
177JUN_21703547_ChIP-Seq_K562_Human0.77802116

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.38820619
2MP0000920_abnormal_myelination3.81643369
3MP0001529_abnormal_vocalization3.61727451
4MP0004270_analgesia3.36499102
5MP0003186_abnormal_redox_activity3.04989945
6MP0008058_abnormal_DNA_repair3.04424766
7MP0001905_abnormal_dopamine_level3.00156504
8MP0010030_abnormal_orbit_morphology2.75498323
9MP0002272_abnormal_nervous_system2.68066331
10MP0003123_paternal_imprinting2.61573204
11MP0003693_abnormal_embryo_hatching2.45979563
12MP0002064_seizures2.45035724
13MP0004142_abnormal_muscle_tone2.44341714
14MP0004859_abnormal_synaptic_plasticity2.40668466
15MP0006292_abnormal_olfactory_placode2.40429887
16MP0003718_maternal_effect2.33783514
17MP0009046_muscle_twitch2.25441170
18MP0003950_abnormal_plasma_membrane2.21401709
19MP0002734_abnormal_mechanical_nocicepti2.20975751
20MP0001486_abnormal_startle_reflex2.19213620
21MP0010094_abnormal_chromosome_stability2.16169727
22MP0006035_abnormal_mitochondrial_morpho2.13807454
23MP0009745_abnormal_behavioral_response2.12837018
24MP0005423_abnormal_somatic_nervous2.10051175
25MP0003111_abnormal_nucleus_morphology2.09607897
26MP0003635_abnormal_synaptic_transmissio2.09402467
27MP0004957_abnormal_blastocyst_morpholog2.05423763
28MP0008932_abnormal_embryonic_tissue2.03616260
29MP0005171_absent_coat_pigmentation2.02172529
30MP0003329_amyloid_beta_deposits1.98738838
31MP0003634_abnormal_glial_cell1.93194070
32MP0001485_abnormal_pinna_reflex1.91282091
33MP0000778_abnormal_nervous_system1.90813615
34MP0001968_abnormal_touch/_nociception1.83324705
35MP0004742_abnormal_vestibular_system1.83022242
36MP0005670_abnormal_white_adipose1.82845115
37MP0003786_premature_aging1.79839524
38MP0003690_abnormal_glial_cell1.74733528
39MP0002653_abnormal_ependyma_morphology1.74182902
40MP0003121_genomic_imprinting1.72922367
41MP0008007_abnormal_cellular_replicative1.72902541
42MP0002572_abnormal_emotion/affect_behav1.72112657
43MP0003136_yellow_coat_color1.71470787
44MP0005409_darkened_coat_color1.71156900
45MP0001970_abnormal_pain_threshold1.68882887
46MP0001440_abnormal_grooming_behavior1.67465903
47MP0002736_abnormal_nociception_after1.67368224
48MP0004885_abnormal_endolymph1.64333084
49MP0002229_neurodegeneration1.63814216
50MP0002735_abnormal_chemical_nociception1.60631454
51MP0004147_increased_porphyrin_level1.58937507
52MP0003077_abnormal_cell_cycle1.58654307
53MP0006276_abnormal_autonomic_nervous1.57834918
54MP0002063_abnormal_learning/memory/cond1.56963654
55MP0002733_abnormal_thermal_nociception1.55198134
56MP0002067_abnormal_sensory_capabilities1.51813476
57MP0008877_abnormal_DNA_methylation1.50878594
58MP0000955_abnormal_spinal_cord1.46885152
59MP0000358_abnormal_cell_content/1.46423908
60MP0003011_delayed_dark_adaptation1.45622080
61MP0004924_abnormal_behavior1.44417687
62MP0005386_behavior/neurological_phenoty1.44417687
63MP0000751_myopathy1.41198085
64MP0004043_abnormal_pH_regulation1.40370362
65MP0002882_abnormal_neuron_morphology1.40056915
66MP0000749_muscle_degeneration1.36432736
67MP0002837_dystrophic_cardiac_calcinosis1.35908305
68MP0005084_abnormal_gallbladder_morpholo1.33804442
69MP0005410_abnormal_fertilization1.33254994
70MP0000750_abnormal_muscle_regeneration1.32969017
71MP0002066_abnormal_motor_capabilities/c1.31632920
72MP0004145_abnormal_muscle_electrophysio1.31352552
73MP0003632_abnormal_nervous_system1.30498080
74MP0001986_abnormal_taste_sensitivity1.28050026
75MP0008569_lethality_at_weaning1.25943255
76MP0005551_abnormal_eye_electrophysiolog1.24993968
77MP0002822_catalepsy1.24727708
78MP0000747_muscle_weakness1.23306700
79MP0002752_abnormal_somatic_nervous1.21353725
80MP0006072_abnormal_retinal_apoptosis1.19980664
81MP0001963_abnormal_hearing_physiology1.18100825
82MP0005330_cardiomyopathy1.17618832
83MP0003122_maternal_imprinting1.17007220
84MP0004134_abnormal_chest_morphology1.15451284
85MP0009697_abnormal_copulation1.15361473
86MP0008789_abnormal_olfactory_epithelium1.15214859
87MP0004036_abnormal_muscle_relaxation1.14976596
88MP0002184_abnormal_innervation1.13506416
89MP0001293_anophthalmia1.07211477
90MP0005165_increased_susceptibility_to1.06575469
91MP0003631_nervous_system_phenotype1.06446206
92MP0002163_abnormal_gland_morphology1.05785665
93MP0000462_abnormal_digestive_system1.05078203
94MP0008260_abnormal_autophagy1.03377188
95MP0003806_abnormal_nucleotide_metabolis1.02140572
96MP0001188_hyperpigmentation0.98962373
97MP0003137_abnormal_impulse_conducting0.98952785
98MP0008775_abnormal_heart_ventricle0.97776979
99MP0005646_abnormal_pituitary_gland0.96646956
100MP0003787_abnormal_imprinting0.96192021
101MP0006036_abnormal_mitochondrial_physio0.95688568
102MP0001764_abnormal_homeostasis0.94937837
103MP0008872_abnormal_physiological_respon0.93407710
104MP0002938_white_spotting0.93213507
105MP0005645_abnormal_hypothalamus_physiol0.92103438
106MP0000013_abnormal_adipose_tissue0.92024708
107MP0002557_abnormal_social/conspecific_i0.91788078
108MP0003283_abnormal_digestive_organ0.91111317
109MP0002210_abnormal_sex_determination0.90311005
110MP0001984_abnormal_olfaction0.89989806
111MP0001501_abnormal_sleep_pattern0.89475567
112MP0004133_heterotaxia0.89214636
113MP0009379_abnormal_foot_pigmentation0.88751625
114MP0000372_irregular_coat_pigmentation0.88478053
115MP0003938_abnormal_ear_development0.87918192
116MP0002152_abnormal_brain_morphology0.87292056
117MP0003119_abnormal_digestive_system0.86850429
118MP0003633_abnormal_nervous_system0.86580951
119MP0001299_abnormal_eye_distance/0.86123448
120MP0002751_abnormal_autonomic_nervous0.85103382
121MP0000026_abnormal_inner_ear0.85008494
122MP0004811_abnormal_neuron_physiology0.84509214
123MP0002102_abnormal_ear_morphology0.83509511
124MP0001727_abnormal_embryo_implantation0.82967837
125MP0005332_abnormal_amino_acid0.82881953
126MP0003315_abnormal_perineum_morphology0.82591999
127MP0000049_abnormal_middle_ear0.81036039
128MP0002254_reproductive_system_inflammat0.80504368
129MP0000631_abnormal_neuroendocrine_gland0.79308817
130MP0000516_abnormal_urinary_system0.78916953
131MP0005367_renal/urinary_system_phenotyp0.78916953
132MP0005253_abnormal_eye_physiology0.78095131
133MP0001145_abnormal_male_reproductive0.76332619
134MP0005623_abnormal_meninges_morphology0.75469427
135MP0005195_abnormal_posterior_eye0.74291278
136MP0000653_abnormal_sex_gland0.73141924
137MP0005636_abnormal_mineral_homeostasis0.72983275
138MP0003646_muscle_fatigue0.72845841
139MP0001542_abnormal_bone_strength0.72438274
140MP0008995_early_reproductive_senescence0.71748117
141MP0000762_abnormal_tongue_morphology0.70889457
142MP0004085_abnormal_heartbeat0.70578207
143MP0001929_abnormal_gametogenesis0.68537012
144MP0002295_abnormal_pulmonary_circulatio0.68104298
145MP0003698_abnormal_male_reproductive0.68071731
146MP0002106_abnormal_muscle_physiology0.67992186
147MP0005451_abnormal_body_composition0.67714538
148MP0001502_abnormal_circadian_rhythm0.67190601
149MP0003567_abnormal_fetal_cardiomyocyte0.66377069
150MP0001664_abnormal_digestion0.64783438
151MP0005499_abnormal_olfactory_system0.64676468
152MP0005394_taste/olfaction_phenotype0.64676468
153MP0000313_abnormal_cell_death0.63009779
154MP0000604_amyloidosis0.62187448
155MP0002160_abnormal_reproductive_system0.61537041
156MP0005379_endocrine/exocrine_gland_phen0.59815078
157MP0005369_muscle_phenotype0.59519837
158MP0009278_abnormal_bone_marrow0.59463653
159MP0009250_abnormal_appendicular_skeleto0.58559185

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolysis (HP:0004366)4.71927734
2Increased serum pyruvate (HP:0003542)4.71927734
3Degeneration of the lateral corticospinal tracts (HP:0002314)4.71860857
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.71860857
5Acute necrotizing encephalopathy (HP:0006965)4.68284400
6Sensory axonal neuropathy (HP:0003390)4.27257888
7Cerebral hypomyelination (HP:0006808)4.18514635
8Abnormal mitochondria in muscle tissue (HP:0008316)4.17344091
9Neurofibrillary tangles (HP:0002185)4.13088443
10Mitochondrial inheritance (HP:0001427)4.02414929
11Parakeratosis (HP:0001036)4.01795169
12Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.94714693
13Leukodystrophy (HP:0002415)3.82945692
14Progressive macrocephaly (HP:0004481)3.81733566
15Acute encephalopathy (HP:0006846)3.78409836
16Hepatocellular necrosis (HP:0001404)3.64239360
17Abnormal number of erythroid precursors (HP:0012131)3.54393358
18Myokymia (HP:0002411)3.49882822
19Reticulocytopenia (HP:0001896)3.44549040
20Pheochromocytoma (HP:0002666)3.44101326
21Abnormality of cells of the erythroid lineage (HP:0012130)3.30495157
22Abnormality of the corticospinal tract (HP:0002492)3.28061321
23Type I transferrin isoform profile (HP:0003642)3.27817146
24Increased CSF lactate (HP:0002490)3.27010313
25Peripheral hypomyelination (HP:0007182)3.26800263
26Renal Fanconi syndrome (HP:0001994)3.21936019
27Neuroendocrine neoplasm (HP:0100634)3.20637984
28Exertional dyspnea (HP:0002875)2.95113687
29Cerebral inclusion bodies (HP:0100314)2.90690679
30Aplasia/Hypoplasia of the sacrum (HP:0008517)2.85495275
31Retinal dysplasia (HP:0007973)2.80795962
32Hepatic necrosis (HP:0002605)2.80622930
33Increased hepatocellular lipid droplets (HP:0006565)2.79306293
34Testicular atrophy (HP:0000029)2.79276247
35CNS hypomyelination (HP:0003429)2.77831172
36Abnormal protein glycosylation (HP:0012346)2.66122742
37Abnormal glycosylation (HP:0012345)2.66122742
38Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.66122742
39Abnormal protein N-linked glycosylation (HP:0012347)2.66122742
40Supranuclear gaze palsy (HP:0000605)2.65882234
41Spastic gait (HP:0002064)2.64635464
42Focal motor seizures (HP:0011153)2.63407869
43Respiratory failure (HP:0002878)2.61798362
44Congenital ichthyosiform erythroderma (HP:0007431)2.59754950
453-Methylglutaconic aciduria (HP:0003535)2.51250722
46Optic disc pallor (HP:0000543)2.49290833
47Microvesicular hepatic steatosis (HP:0001414)2.48973477
48Dysmetria (HP:0001310)2.47478967
49Macrocytic anemia (HP:0001972)2.45215112
50Akinesia (HP:0002304)2.44490042
51Atonic seizures (HP:0010819)2.44036172
52Lipid accumulation in hepatocytes (HP:0006561)2.42865276
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.35870745
54Split foot (HP:0001839)2.33789465
55Methylmalonic aciduria (HP:0012120)2.33640758
56Lethargy (HP:0001254)2.31010503
57Hypoplastic pelvis (HP:0008839)2.30485882
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.29023793
59Autoamputation (HP:0001218)2.27159696
60CNS demyelination (HP:0007305)2.26294121
61Reduced antithrombin III activity (HP:0001976)2.25847443
62Alacrima (HP:0000522)2.25429558
63Spastic paraparesis (HP:0002313)2.25052067
64Respiratory difficulties (HP:0002880)2.24282952
65Colon cancer (HP:0003003)2.23866586
66Dicarboxylic aciduria (HP:0003215)2.23411266
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.23411266
68Limb dystonia (HP:0002451)2.20681736
69Ankle clonus (HP:0011448)2.20606579
70Abnormality of the anterior horn cell (HP:0006802)2.20604381
71Degeneration of anterior horn cells (HP:0002398)2.20604381
72Hyperalaninemia (HP:0003348)2.17323614
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.17323614
74Abnormality of alanine metabolism (HP:0010916)2.17323614
75Onion bulb formation (HP:0003383)2.16696722
76Cerebral hemorrhage (HP:0001342)2.14214795
77Exercise intolerance (HP:0003546)2.13685412
78Increased intramyocellular lipid droplets (HP:0012240)2.12688395
79Pancytopenia (HP:0001876)2.12303997
80Cerebral edema (HP:0002181)2.11253613
81Abnormality of the labia minora (HP:0012880)2.09878744
82Hyperglycinemia (HP:0002154)2.09161239
83Scanning speech (HP:0002168)2.08250591
84Lactic acidosis (HP:0003128)2.07853885
85Opisthotonus (HP:0002179)2.05651003
86Decreased activity of mitochondrial respiratory chain (HP:0008972)2.04321345
87Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.04321345
88Absent septum pellucidum (HP:0001331)2.03690173
89Ragged-red muscle fibers (HP:0003200)2.02428794
90Cholecystitis (HP:0001082)1.99845164
91Abnormal gallbladder physiology (HP:0012438)1.99845164
92Intention tremor (HP:0002080)1.99724919
93Vaginal atresia (HP:0000148)1.98586791
94Progressive muscle weakness (HP:0003323)1.98548291
95Epileptic encephalopathy (HP:0200134)1.98291460
96Stridor (HP:0010307)1.98219270
97Poor speech (HP:0002465)1.98173372
98Abnormal auditory evoked potentials (HP:0006958)1.97954148
99Foot dorsiflexor weakness (HP:0009027)1.94325463
100Poor suck (HP:0002033)1.93452552
101Genital tract atresia (HP:0001827)1.93098033
102Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.92909974
103Methylmalonic acidemia (HP:0002912)1.92253234
104Abnormal pupillary function (HP:0007686)1.92196822
105Muscle fiber splitting (HP:0003555)1.92162503
106X-linked dominant inheritance (HP:0001423)1.91952249
107Increased serum lactate (HP:0002151)1.91349937
108Rough bone trabeculation (HP:0100670)1.90940473
109Insidious onset (HP:0003587)1.90512210
110Termporal pattern (HP:0011008)1.90512210
111Muscle hypertrophy of the lower extremities (HP:0008968)1.89545510
112Slow saccadic eye movements (HP:0000514)1.89384055
113Abnormality of renal resorption (HP:0011038)1.88863605
114Progressive inability to walk (HP:0002505)1.85729186
115Progressive microcephaly (HP:0000253)1.85527429
116Postnatal microcephaly (HP:0005484)1.85010768
117Delayed CNS myelination (HP:0002188)1.84332005
118Abnormality of the septum pellucidum (HP:0007375)1.84065325
119Aplastic anemia (HP:0001915)1.83639471
120Hypothermia (HP:0002045)1.82771366
121Blindness (HP:0000618)1.82560667
122Thickened helices (HP:0000391)1.80749854
123Hypomagnesemia (HP:0002917)1.80639784
124Gliosis (HP:0002171)1.78560468
125Hypoplastic left heart (HP:0004383)1.78515961
126Diminished movement (HP:0002374)1.78143243
127Medial flaring of the eyebrow (HP:0010747)1.77971629
128Unsteady gait (HP:0002317)1.77568365
129Morphological abnormality of the inner ear (HP:0011390)1.77561875
130Clumsiness (HP:0002312)1.77118733
131Megalencephaly (HP:0001355)1.76818661
132Abnormality of the foot musculature (HP:0001436)1.76223039
133Adrenal hypoplasia (HP:0000835)1.75605021
134Emotional lability (HP:0000712)1.75021330
135Anteriorly placed anus (HP:0001545)1.74861850
136Microretrognathia (HP:0000308)1.74823336
137Generalized aminoaciduria (HP:0002909)1.73610427
138Absent thumb (HP:0009777)1.73081392
139Muscle fiber atrophy (HP:0100295)1.72686512
140Hypoglycemic coma (HP:0001325)1.71594124
141Gait imbalance (HP:0002141)1.70910799
142Respiratory insufficiency due to muscle weakness (HP:0002747)1.70772349
143Increased muscle lipid content (HP:0009058)1.70633326
144Increased circulating renin level (HP:0000848)1.69703665
145Abnormality of urine glucose concentration (HP:0011016)1.69574035
146Glycosuria (HP:0003076)1.69574035
147Partial duplication of thumb phalanx (HP:0009944)1.69475559
148Sclerocornea (HP:0000647)1.69184760
149Synostosis involving the elbow (HP:0003938)1.68691159
150Humeroradial synostosis (HP:0003041)1.68691159
151Delusions (HP:0000746)1.68146078
152Abnormality of magnesium homeostasis (HP:0004921)1.67478941
153Upper limb muscle weakness (HP:0003484)1.66976022
154Congenital, generalized hypertrichosis (HP:0004540)1.62747731
155Abnormality of serum amino acid levels (HP:0003112)1.62485520
156Cleft eyelid (HP:0000625)1.61967475
157Oligomenorrhea (HP:0000876)1.61767589
158Hyperglycinuria (HP:0003108)1.60930457
159Myoglobinuria (HP:0002913)1.55940707
160Cerebral palsy (HP:0100021)1.54318463
161Abnormality of aromatic amino acid family metabolism (HP:0004338)1.52985372
162Rhabdomyolysis (HP:0003201)1.50149981
163Sparse eyelashes (HP:0000653)1.48984423

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.71045145
2STK395.16800693
3NME24.14404694
4OXSR13.93476133
5CDK192.93679793
6BCKDK2.85802292
7BCR2.72757649
8LIMK12.55421733
9ZAK2.54433000
10PRPF4B2.35498747
11WNK42.32596158
12CASK2.32038908
13TESK22.27528802
14PNCK2.15683909
15TNIK2.13508364
16EPHB12.13288777
17CDC72.08961148
18MAPKAPK52.03214819
19UHMK11.98346897
20KDR1.96838607
21PBK1.91866761
22PKN11.89973378
23STK161.86774739
24CSNK1G31.84210062
25MET1.79087386
26ARAF1.77695889
27MUSK1.73275020
28NUAK11.71949722
29DAPK11.66393687
30MAP3K111.63738348
31MST41.63533960
32CAMK2B1.56782343
33NEK11.48886347
34ROCK21.45390420
35NTRK11.44206540
36NEK61.43278299
37PLK31.43263269
38WNK11.43172042
39CSNK1A1L1.42019954
40NME11.40808026
41CAMK2D1.39343715
42SRPK11.37521889
43MAP4K21.33660645
44CSNK1G21.28040127
45TAF11.27318276
46ABL21.26557580
47CSNK1G11.23842438
48MARK11.23050164
49DYRK21.17691207
50EPHA41.16889864
51FGR1.15901741
52MAP3K121.13542591
53TTK1.12143393
54AURKA1.11276246
55PHKG21.10878909
56PHKG11.10878909
57CDK141.08732293
58BUB11.08576477
59CAMK2G1.07941831
60PLK11.04546961
61GRK71.02315442
62SGK2230.98068479
63SGK4940.98068479
64PLK40.96781632
65LMTK20.96225923
66CDK180.94883845
67CAMK2A0.94666043
68CDK150.94540413
69ICK0.93743537
70BRSK10.93121791
71FGFR20.88976673
72GRK50.87771826
73MYLK0.86812164
74CDK11A0.86721316
75CDK50.85139985
76MAPKAPK30.83847376
77CCNB10.82765406
78CHEK20.82029935
79ADRBK20.79906908
80PAK60.79266811
81BMPR1B0.78136653
82OBSCN0.78026514
83CDK80.77386073
84EIF2AK10.75306115
85PRKCE0.74892489
86MAPK130.74779494
87MINK10.72772214
88PAK30.72624896
89CLK10.72322718
90AURKB0.71673003
91MAP2K70.71474630
92NTRK30.70795432
93BRAF0.69423361
94TIE10.67414829
95ATR0.65309734
96GRK10.65080567
97PLK20.64263515
98DAPK20.63794908
99VRK10.63164556
100MARK20.58697047
101PAK10.57603604
102PDK20.57070137
103LRRK20.56988684
104PAK40.56819924
105NTRK20.56064427
106DAPK30.55787153
107INSRR0.54855802
108ILK0.53859190
109CSNK2A20.53833060
110EPHA20.53813303
111TLK10.53227767
112PRKCI0.52683083
113TAOK20.52485754
114TRIM280.50338943
115PINK10.50261448
116BMX0.49988291
117CSNK2A10.49915617
118ERBB40.49319697
119RPS6KA50.48257407
120PIM20.47205661
121PTK2B0.45578693
122SMG10.44158571
123TSSK60.43822526
124MAP3K40.43727744
125CDK70.43582429
126MAPK150.42161622
127PRKD10.41425488
128PRKCG0.40845468
129PRKD30.40531812
130TYRO30.40050730
131ADRBK10.39971166
132IRAK20.39627940
133PRKACA0.39433319
134PRKG10.38065362
135PRKCQ0.37458088
136CSNK1A10.36150647
137FLT30.36058600
138DYRK30.36017424
139MAP2K20.35457215
140MAP3K90.35413893
141MKNK10.35287646
142PDPK10.35240952
143EPHB20.34898230
144STK40.34252293
145TRPM70.33614843
146WNK30.33281054
147PRKACB0.33142795
148PRKG20.32954034
149TESK10.31866359
150FYN0.31169341
151ROCK10.29874733

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.94533882
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.43578781
3Parkinsons disease_Homo sapiens_hsa050124.15184865
4Fatty acid elongation_Homo sapiens_hsa000623.42553626
5DNA replication_Homo sapiens_hsa030303.36293896
6Alzheimers disease_Homo sapiens_hsa050103.19903323
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.01452086
8Steroid biosynthesis_Homo sapiens_hsa001002.93437185
9Mismatch repair_Homo sapiens_hsa034302.73167817
10Huntingtons disease_Homo sapiens_hsa050162.70245898
11Base excision repair_Homo sapiens_hsa034102.62556783
12Protein export_Homo sapiens_hsa030602.61387774
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.37268826
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.26154783
15Proteasome_Homo sapiens_hsa030502.22326807
16Cardiac muscle contraction_Homo sapiens_hsa042602.20887227
17Collecting duct acid secretion_Homo sapiens_hsa049662.17678435
18Homologous recombination_Homo sapiens_hsa034402.10229998
19Ether lipid metabolism_Homo sapiens_hsa005652.09014677
20Sulfur relay system_Homo sapiens_hsa041222.07313009
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.89586090
22Vibrio cholerae infection_Homo sapiens_hsa051101.77332403
23Nucleotide excision repair_Homo sapiens_hsa034201.71413289
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.67262988
25Synaptic vesicle cycle_Homo sapiens_hsa047211.65817039
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62635709
27RNA polymerase_Homo sapiens_hsa030201.59079958
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.49045597
29Biosynthesis of amino acids_Homo sapiens_hsa012301.47998779
30Spliceosome_Homo sapiens_hsa030401.47441839
31Sulfur metabolism_Homo sapiens_hsa009201.46583220
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46263996
33Ribosome_Homo sapiens_hsa030101.44542302
34GABAergic synapse_Homo sapiens_hsa047271.41453609
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.40344615
36One carbon pool by folate_Homo sapiens_hsa006701.39516814
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38422984
38Carbon metabolism_Homo sapiens_hsa012001.34737351
39Nicotine addiction_Homo sapiens_hsa050331.32305877
40Serotonergic synapse_Homo sapiens_hsa047261.31125102
41Fanconi anemia pathway_Homo sapiens_hsa034601.26812925
42Pentose phosphate pathway_Homo sapiens_hsa000301.23846322
43Axon guidance_Homo sapiens_hsa043601.23307184
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20746054
45Sphingolipid metabolism_Homo sapiens_hsa006001.20664697
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.19114837
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10035947
48RNA transport_Homo sapiens_hsa030131.08827760
49Glutamatergic synapse_Homo sapiens_hsa047241.05782461
50Morphine addiction_Homo sapiens_hsa050321.02790088
51Butanoate metabolism_Homo sapiens_hsa006501.02723790
52Linoleic acid metabolism_Homo sapiens_hsa005910.99549195
53RNA degradation_Homo sapiens_hsa030180.98231143
54Rheumatoid arthritis_Homo sapiens_hsa053230.95686931
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95517678
56Vitamin B6 metabolism_Homo sapiens_hsa007500.93419857
57Non-homologous end-joining_Homo sapiens_hsa034500.91728322
58Long-term depression_Homo sapiens_hsa047300.90303805
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90057681
60Galactose metabolism_Homo sapiens_hsa000520.86661910
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86074960
62Pyruvate metabolism_Homo sapiens_hsa006200.84783881
63Glutathione metabolism_Homo sapiens_hsa004800.84581726
64Circadian entrainment_Homo sapiens_hsa047130.84434829
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83196073
66Cocaine addiction_Homo sapiens_hsa050300.83018098
67Dopaminergic synapse_Homo sapiens_hsa047280.82144653
68Arginine and proline metabolism_Homo sapiens_hsa003300.79829621
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79593413
70N-Glycan biosynthesis_Homo sapiens_hsa005100.76135219
71Fructose and mannose metabolism_Homo sapiens_hsa000510.76003395
72Peroxisome_Homo sapiens_hsa041460.75918439
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75399173
74Arachidonic acid metabolism_Homo sapiens_hsa005900.74477059
75Selenocompound metabolism_Homo sapiens_hsa004500.72312924
76Phagosome_Homo sapiens_hsa041450.72202005
77Phototransduction_Homo sapiens_hsa047440.70785837
78Metabolic pathways_Homo sapiens_hsa011000.69313710
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68931976
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68065198
81Taste transduction_Homo sapiens_hsa047420.66222450
82Cholinergic synapse_Homo sapiens_hsa047250.63321113
83Propanoate metabolism_Homo sapiens_hsa006400.62943080
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61202381
85Basal transcription factors_Homo sapiens_hsa030220.58587230
86Tight junction_Homo sapiens_hsa045300.58175280
87Amphetamine addiction_Homo sapiens_hsa050310.57925300
88Salivary secretion_Homo sapiens_hsa049700.56049742
89Regulation of autophagy_Homo sapiens_hsa041400.55556470
90Cell cycle_Homo sapiens_hsa041100.54547615
91Renal cell carcinoma_Homo sapiens_hsa052110.54051452
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53820104
93Gap junction_Homo sapiens_hsa045400.53503056
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52953158
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.52545170
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.51622919
97Gastric acid secretion_Homo sapiens_hsa049710.50323607
98Histidine metabolism_Homo sapiens_hsa003400.49203353
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.47752279
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46848874
101Alcoholism_Homo sapiens_hsa050340.46516876
102Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43514919
103Olfactory transduction_Homo sapiens_hsa047400.41706441
104Purine metabolism_Homo sapiens_hsa002300.41504438
105Endocytosis_Homo sapiens_hsa041440.41244294
106Hedgehog signaling pathway_Homo sapiens_hsa043400.40469610
107Oocyte meiosis_Homo sapiens_hsa041140.40127566
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39249976
109Calcium signaling pathway_Homo sapiens_hsa040200.37892833
110Ras signaling pathway_Homo sapiens_hsa040140.37428334
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37269660
112Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36575343
113beta-Alanine metabolism_Homo sapiens_hsa004100.35926608
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.35528971
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34123898
116Phenylalanine metabolism_Homo sapiens_hsa003600.33072838
117Long-term potentiation_Homo sapiens_hsa047200.33032746
118Lysosome_Homo sapiens_hsa041420.32983685
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32982221
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.32004410
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31931001
122Tryptophan metabolism_Homo sapiens_hsa003800.31898409
123Dilated cardiomyopathy_Homo sapiens_hsa054140.31281797
124Insulin secretion_Homo sapiens_hsa049110.31071166
125Fatty acid metabolism_Homo sapiens_hsa012120.30938157
126Nitrogen metabolism_Homo sapiens_hsa009100.29844313
127ErbB signaling pathway_Homo sapiens_hsa040120.29105382
128Renin secretion_Homo sapiens_hsa049240.29037639
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28445242
130Autoimmune thyroid disease_Homo sapiens_hsa053200.27901912
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.27860524
132Pancreatic secretion_Homo sapiens_hsa049720.27419888
133Tyrosine metabolism_Homo sapiens_hsa003500.27222605
134Folate biosynthesis_Homo sapiens_hsa007900.26728922
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25963133
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.25668541
137Fatty acid degradation_Homo sapiens_hsa000710.25622102
138Ovarian steroidogenesis_Homo sapiens_hsa049130.25091755
139Systemic lupus erythematosus_Homo sapiens_hsa053220.24436890
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23389092
141Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23346047
142Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22879220
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22617364
144Oxytocin signaling pathway_Homo sapiens_hsa049210.21212682
145Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20816833
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18440538
147Pyrimidine metabolism_Homo sapiens_hsa002400.18422912
148Arginine biosynthesis_Homo sapiens_hsa002200.15068380
149Basal cell carcinoma_Homo sapiens_hsa052170.14387918
150Fat digestion and absorption_Homo sapiens_hsa049750.13135002
151Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12092642
152p53 signaling pathway_Homo sapiens_hsa041150.10634428
153Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.09478251

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