ARL2BP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of mitochondrial fission (GO:0090141)5.36458095
2Golgi transport vesicle coating (GO:0048200)5.24114845
3COPI coating of Golgi vesicle (GO:0048205)5.24114845
4locomotory exploration behavior (GO:0035641)4.87586964
5sequestering of actin monomers (GO:0042989)4.86703406
6synaptic vesicle maturation (GO:0016188)4.85964644
7cullin deneddylation (GO:0010388)4.68697943
8protein deneddylation (GO:0000338)4.61359207
9layer formation in cerebral cortex (GO:0021819)4.61041698
10negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.33800898
11pyrimidine nucleobase catabolic process (GO:0006208)4.33337598
12sodium ion export (GO:0071436)4.31266284
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.08181498
14regulation of short-term neuronal synaptic plasticity (GO:0048172)3.99601108
15membrane budding (GO:0006900)3.93933294
16glycosphingolipid biosynthetic process (GO:0006688)3.84362683
17metallo-sulfur cluster assembly (GO:0031163)3.74460679
18iron-sulfur cluster assembly (GO:0016226)3.74460679
19L-serine transport (GO:0015825)3.66156630
20cellular potassium ion homeostasis (GO:0030007)3.65906244
21cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.55878976
22protein retention in ER lumen (GO:0006621)3.54402828
23cell communication by electrical coupling (GO:0010644)3.54048263
24positive regulation of TOR signaling (GO:0032008)3.50208088
25activation of protein kinase A activity (GO:0034199)3.47834046
26regulation of synaptic vesicle exocytosis (GO:2000300)3.45626117
27maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.44231138
28cytoskeletal anchoring at plasma membrane (GO:0007016)3.43379454
29regulation of synapse structural plasticity (GO:0051823)3.39517559
30synaptic vesicle exocytosis (GO:0016079)3.39142759
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.36035379
32exploration behavior (GO:0035640)3.35351541
33glutamate secretion (GO:0014047)3.32806556
34protein heterotrimerization (GO:0070208)3.30130705
35negative regulation of smooth muscle cell migration (GO:0014912)3.29800886
36ribonucleoprotein complex disassembly (GO:0032988)3.29088402
37retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.28444186
38growth hormone secretion (GO:0030252)3.27018088
39nucleoside diphosphate biosynthetic process (GO:0009133)3.25703497
40type B pancreatic cell proliferation (GO:0044342)3.22756622
41synaptic vesicle docking involved in exocytosis (GO:0016081)3.20563333
422-deoxyribonucleotide biosynthetic process (GO:0009265)3.20263075
43deoxyribose phosphate biosynthetic process (GO:0046385)3.20263075
44potassium ion import (GO:0010107)3.20190269
45L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.18405395
46de novo posttranslational protein folding (GO:0051084)3.17678718
47regulation of mitochondrial fission (GO:0090140)3.15523847
48establishment of nucleus localization (GO:0040023)3.14643198
49negative regulation of potassium ion transmembrane transport (GO:1901380)3.13916561
50positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.13138086
51positive regulation of actin filament depolymerization (GO:0030836)3.12457700
52mitochondrial calcium ion transport (GO:0006851)3.11950899
53negative regulation of microtubule polymerization (GO:0031115)3.10264250
54succinate metabolic process (GO:0006105)3.09862272
55vocalization behavior (GO:0071625)3.07965114
56barbed-end actin filament capping (GO:0051016)3.07417335
57regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.05290438
58regulation of ARF protein signal transduction (GO:0032012)3.05018776
59negative regulation of synaptic transmission, GABAergic (GO:0032229)3.03694469
60regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.01742615
61positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.01361930
62nucleobase catabolic process (GO:0046113)3.01361907
63glycolipid biosynthetic process (GO:0009247)3.00586795
64membrane repolarization (GO:0086009)3.00139241
65dendritic spine morphogenesis (GO:0060997)2.97842786
66serine transport (GO:0032329)2.96903075
67negative regulation of organelle assembly (GO:1902116)2.94649414
68de novo protein folding (GO:0006458)2.93828953
69amino acid salvage (GO:0043102)2.92221496
70L-methionine salvage (GO:0071267)2.92221496
71L-methionine biosynthetic process (GO:0071265)2.92221496
72cerebral cortex neuron differentiation (GO:0021895)2.92087706
73virion assembly (GO:0019068)2.92071659
74hemoglobin metabolic process (GO:0020027)2.91464332
75positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.91379588
76regulation of synaptic vesicle transport (GO:1902803)2.89726670
77dendrite morphogenesis (GO:0048813)2.88919281
78negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.88607435
79viral protein processing (GO:0019082)2.87125606
80COPII vesicle coating (GO:0048208)2.86117803
81GPI anchor biosynthetic process (GO:0006506)2.84958708
82plasma membrane repair (GO:0001778)2.82611427
83regulation of glutamate receptor signaling pathway (GO:1900449)2.82037896
84negative regulation of inclusion body assembly (GO:0090084)2.81105735
85regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.81036268
86neurotransmitter secretion (GO:0007269)2.80335275
87polyketide metabolic process (GO:0030638)2.79840227
88doxorubicin metabolic process (GO:0044598)2.79840227
89daunorubicin metabolic process (GO:0044597)2.79840227
90energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.79323554
91ATP hydrolysis coupled proton transport (GO:0015991)2.79323554
92neuronal action potential propagation (GO:0019227)2.77671920
93regulation of neuronal synaptic plasticity (GO:0048168)2.76487455
94potassium ion homeostasis (GO:0055075)2.76216333
95vesicle coating (GO:0006901)2.76079352
96cellular response to leptin stimulus (GO:0044320)2.74780563
97regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.73983099
98neuromuscular process controlling balance (GO:0050885)2.73355546
99peptidyl-lysine dimethylation (GO:0018027)2.73265154
100cholesterol biosynthetic process (GO:0006695)2.72754011
101ADP metabolic process (GO:0046031)2.72412506
102extracellular fibril organization (GO:0043206)2.71805841
103positive regulation of potassium ion transmembrane transport (GO:1901381)2.71712037
104cerebellar Purkinje cell layer development (GO:0021680)2.71319551
105negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.71304409
106regulation of development, heterochronic (GO:0040034)2.71176252
107response to gravity (GO:0009629)2.70903613
108cell migration in hindbrain (GO:0021535)2.70892181
109response to redox state (GO:0051775)2.70829179
110lipopolysaccharide biosynthetic process (GO:0009103)2.70428017
111intraciliary transport (GO:0042073)2.69650263
112protein insertion into membrane (GO:0051205)2.69308001
113clathrin coat assembly (GO:0048268)2.68739608
114protein localization to endosome (GO:0036010)2.68417866
115regulation of long-term neuronal synaptic plasticity (GO:0048169)2.67966281
116negative regulation of oligodendrocyte differentiation (GO:0048715)2.67710328
117acrosome reaction (GO:0007340)2.66894411
118GPI anchor metabolic process (GO:0006505)2.65243795
119regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.65040090
120protein localization to synapse (GO:0035418)2.64711033
121RNA localization (GO:0006403)2.64656787
122negative regulation of JAK-STAT cascade (GO:0046426)2.63422860
123chaperone-mediated protein transport (GO:0072321)2.62495866
124vesicle transport along microtubule (GO:0047496)2.62011701
125regulation of ARF GTPase activity (GO:0032312)2.61894662
126muscle cell cellular homeostasis (GO:0046716)2.61802760
127protein targeting to plasma membrane (GO:0072661)2.61189350
128regulation of cellular amino acid metabolic process (GO:0006521)2.59096882
129nerve growth factor signaling pathway (GO:0038180)2.58602955
130proline transport (GO:0015824)2.57855226
131mitochondrial calcium ion homeostasis (GO:0051560)2.57737559
132proteasome assembly (GO:0043248)2.56612289
133calcium ion-dependent exocytosis (GO:0017156)2.56226320
134response to leptin (GO:0044321)2.56218689
135ER to Golgi vesicle-mediated transport (GO:0006888)2.55984017
136negative regulation of cell size (GO:0045792)2.55929468
137negative regulation of nitric-oxide synthase activity (GO:0051001)2.54793778
138membrane depolarization during action potential (GO:0086010)2.54701240
139positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.52960505
140cellular sodium ion homeostasis (GO:0006883)2.51788737
141organelle disassembly (GO:1903008)2.51594664
142sterol biosynthetic process (GO:0016126)2.51191548
143acrosome assembly (GO:0001675)2.50263342
144neuronal ion channel clustering (GO:0045161)2.50064620
145membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.47439090
146polyamine metabolic process (GO:0006595)2.47252965
147neuron cell-cell adhesion (GO:0007158)2.45895806
148G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.45757120
149mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.45712536
150positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.45712536
151signal complex assembly (GO:0007172)2.45596030
152purine nucleotide salvage (GO:0032261)2.44819185
153organelle transport along microtubule (GO:0072384)2.44595168
154membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.44592040
155regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.42910461
156regulation of cilium movement (GO:0003352)2.42717043
157axon cargo transport (GO:0008088)2.42519702
158aminoglycoside antibiotic metabolic process (GO:0030647)2.41110576
159stress fiber assembly (GO:0043149)2.40091685
160regulation of dendritic spine morphogenesis (GO:0061001)2.39861817
161negative regulation of Notch signaling pathway (GO:0045746)2.39169017
162mating behavior (GO:0007617)2.39159707
163negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.38402556
164negative regulation of calcium ion transmembrane transport (GO:1903170)2.38402556
165peroxisome fission (GO:0016559)2.37699232
166regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.37626211
167positive regulation of potassium ion transport (GO:0043268)2.37464926
168pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.37111731
169protein localization to cilium (GO:0061512)2.36582271
170cell communication involved in cardiac conduction (GO:0086065)2.36304218
171lens morphogenesis in camera-type eye (GO:0002089)2.36200891
172axonal fasciculation (GO:0007413)2.35564479
173gamma-aminobutyric acid transport (GO:0015812)2.35535563
174regulation of potassium ion transmembrane transporter activity (GO:1901016)2.35352189
175polyamine biosynthetic process (GO:0006596)2.35172223
176glial cell proliferation (GO:0014009)2.34877228
177sperm motility (GO:0030317)2.34301895
178transferrin transport (GO:0033572)2.33621634
179neuron recognition (GO:0008038)2.33047656
180regulation of autophagic vacuole assembly (GO:2000785)2.32787738
181positive regulation of synapse maturation (GO:0090129)2.31980769
182regulation of potassium ion transmembrane transport (GO:1901379)2.31953196
183cerebellar Purkinje cell differentiation (GO:0021702)2.30729435
184regulation of calcium ion transmembrane transport (GO:1903169)2.29995943
185regulation of calcium ion transmembrane transporter activity (GO:1901019)2.29995943
186innervation (GO:0060384)2.28890231
187ionotropic glutamate receptor signaling pathway (GO:0035235)2.27524785
188regulation of NFAT protein import into nucleus (GO:0051532)2.27514974
189regulation of clathrin-mediated endocytosis (GO:2000369)2.25372969
190transmission of nerve impulse (GO:0019226)2.23494940
191prepulse inhibition (GO:0060134)2.22344460
192cellular response to nerve growth factor stimulus (GO:1990090)2.21598139
193response to nerve growth factor (GO:1990089)2.21598139
194long-term memory (GO:0007616)2.21431969
195regulation of membrane repolarization (GO:0060306)2.21159657
196localization within membrane (GO:0051668)2.21112897
197membrane repolarization during action potential (GO:0086011)2.18344114

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.25719527
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.82194155
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.94869800
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.66963361
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.18771593
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91034326
7CREB1_15753290_ChIP-ChIP_HEK293T_Human2.87148695
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.75170794
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.68999423
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.63614704
11PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.46519055
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.41597708
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.39508750
14IGF1R_20145208_ChIP-Seq_DFB_Human2.38890193
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.38368643
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.30027304
17ZFP281_18757296_ChIP-ChIP_E14_Mouse2.29892872
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.25389787
19GABP_19822575_ChIP-Seq_HepG2_Human2.22121078
20DROSHA_22980978_ChIP-Seq_HELA_Human2.19823300
21KDM2B_26808549_Chip-Seq_DND41_Human2.16531672
22KDM2B_26808549_Chip-Seq_SUP-B15_Human2.14801158
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.14569775
24RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11142640
25EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11142640
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.10214030
27MTF2_20144788_ChIP-Seq_MESCs_Mouse2.04318447
28ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.00108238
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.00027659
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.99283469
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.99016798
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.98632882
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97771902
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97088869
35KDM2B_26808549_Chip-Seq_K562_Human1.96194154
36DCP1A_22483619_ChIP-Seq_HELA_Human1.92716348
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.91974080
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89582562
39REST_21632747_ChIP-Seq_MESCs_Mouse1.88791309
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.88125748
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88035811
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.87336799
43TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.85754370
44EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.84501326
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84076901
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.83989814
47VDR_23849224_ChIP-Seq_CD4+_Human1.83274333
48* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82012631
49ELK1_19687146_ChIP-ChIP_HELA_Human1.79112988
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78656438
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.77003357
52ZFP281_27345836_Chip-Seq_ESCs_Mouse1.76770392
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.75867209
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75394717
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.74640524
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72773209
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.72473350
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.72193764
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.72072761
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.69913972
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67108649
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.66417441
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62918890
64ZNF274_21170338_ChIP-Seq_K562_Hela1.60470135
65* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60089672
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.60060201
67SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59496711
68ZNF263_19887448_ChIP-Seq_K562_Human1.59313933
69* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.59070928
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58628878
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.58602309
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57737502
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.56846646
74LXR_22292898_ChIP-Seq_THP-1_Human1.56275213
75SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.55294345
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.52815796
77E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51995818
78* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.51808825
79PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49104305
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48894659
81CLOCK_20551151_ChIP-Seq_293T_Human1.47699840
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46059984
83PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.45587213
84MYC_22102868_ChIP-Seq_BL_Human1.43772691
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43574152
86MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40581689
87TCF7_22412390_ChIP-Seq_EML_Mouse1.39233247
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37662369
89CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36786422
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36632420
91NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36001325
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34218659
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32580901
94WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31058598
95EED_16625203_ChIP-ChIP_MESCs_Mouse1.29883600
96P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29308989
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25573753
98ERG_21242973_ChIP-ChIP_JURKAT_Human1.25238140
99TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.24289037
100RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23982063
101JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21101687
102FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19365299
103FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19331098
104MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18213969
105BP1_19119308_ChIP-ChIP_Hs578T_Human1.17300686
106YY1_21170310_ChIP-Seq_MESCs_Mouse1.17131300
107EP300_21415370_ChIP-Seq_HL-1_Mouse1.16902363
108RING1B_27294783_Chip-Seq_NPCs_Mouse1.16860885
109SMC4_20622854_ChIP-Seq_HELA_Human1.16310116
110ELK3_25401928_ChIP-Seq_HUVEC_Human1.13569527
111OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12726664
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12516885
113MYC_18555785_ChIP-Seq_MESCs_Mouse1.11936199
114CREB1_26743006_Chip-Seq_LNCaP_Human1.10443192
115* FOXP3_21729870_ChIP-Seq_TREG_Human1.09908628
116TTF2_22483619_ChIP-Seq_HELA_Human1.08582742
117CTCF_27219007_Chip-Seq_Bcells_Human1.08564687
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08456695
119MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07262860
120RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07206675
121CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.06787160
122TET1_21490601_ChIP-Seq_MESCs_Mouse1.06572926
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05531434
124TBX20_22080862_ChIP-Seq_HEART_Mouse1.05409554
125TBX20_22328084_ChIP-Seq_HEART_Mouse1.05409554
126TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05251573
127LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04235379
128RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04093647
129BRD4_25478319_ChIP-Seq_HGPS_Human1.03855870
130POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03671786
131CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02568544
132NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02030848
133SA1_22415368_ChIP-Seq_MEFs_Mouse1.01867501
134NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00662256
135ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00627041
136SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99275244
137CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98723988
138PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98484875
139* SMAD_19615063_ChIP-ChIP_OVARY_Human0.97318362
140NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96803512
141XRN2_22483619_ChIP-Seq_HELA_Human0.95959003
142AR_21572438_ChIP-Seq_LNCaP_Human0.95520088
143MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.94947137
144WDR5_24793694_ChIP-Seq_LNCAP_Human0.94146004
145RACK7_27058665_Chip-Seq_MCF-7_Human0.93966394
146TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93957618
147P68_20966046_ChIP-Seq_HELA_Human0.93833049
148TRIM28_21343339_ChIP-Seq_HEK293_Human0.92901574
149KLF4_19829295_ChIP-Seq_ESCs_Human0.92901264
150CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92241753
151ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92118478
152CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91275960
153UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90693450
154GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90342519
155VDR_21846776_ChIP-Seq_THP-1_Human0.89950519
156* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89555150
157CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89442468
158REST_19997604_ChIP-ChIP_NEURONS_Mouse0.89011498
159TFEB_21752829_ChIP-Seq_HELA_Human0.88421227
160* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88298669
161HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88259315
162SMAD3_21741376_ChIP-Seq_ESCs_Human0.88225552
163RUNX1_27514584_Chip-Seq_MCF-7_Human0.88216676
164SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87957948
165RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87447094
166OCT4_19829295_ChIP-Seq_ESCs_Human0.86713034
167TP53_23651856_ChIP-Seq_MEFs_Mouse0.86628017
168CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.86416147
169* AR_19668381_ChIP-Seq_PC3_Human0.86307161
170TP53_22127205_ChIP-Seq_IMR90_Human0.84150692
171SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.84121846
172YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83628621
173SA1_27219007_Chip-Seq_ERYTHROID_Human0.83007660
174ELK4_26923725_Chip-Seq_MESODERM_Mouse0.81809782
175LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81703911
176* ELF1_20517297_ChIP-Seq_JURKAT_Human0.81506301
177CJUN_26792858_Chip-Seq_BT549_Human0.80795585
178CIITA_25753668_ChIP-Seq_RAJI_Human0.78883090
179* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.78825467
180STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.78744371
181CBX2_27304074_Chip-Seq_ESCs_Mouse0.77573464
182NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77002965
183NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77002965
184* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76729767
185RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.76562937
186CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.76265318
187CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.73194971
188CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72910141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.98367511
2MP0008438_abnormal_cutaneous_collagen3.87662931
3MP0008789_abnormal_olfactory_epithelium3.83915941
4MP0010368_abnormal_lymphatic_system3.33467311
5MP0005499_abnormal_olfactory_system3.19125814
6MP0005394_taste/olfaction_phenotype3.19125814
7MP0003635_abnormal_synaptic_transmissio2.83205916
8MP0005410_abnormal_fertilization2.74677796
9MP0004270_analgesia2.69429668
10MP0009384_cardiac_valve_regurgitation2.52566582
11MP0002102_abnormal_ear_morphology2.49800568
12MP0005623_abnormal_meninges_morphology2.49681182
13MP0000049_abnormal_middle_ear2.35138613
14MP0000751_myopathy2.34997047
15MP0003279_aneurysm2.33644007
16MP0004858_abnormal_nervous_system2.32775398
17MP0003880_abnormal_central_pattern2.26098371
18MP0005503_abnormal_tendon_morphology2.19060288
19MP0001542_abnormal_bone_strength2.18372831
20MP0001529_abnormal_vocalization2.13550988
21MP0006054_spinal_hemorrhage2.07324610
22MP0000465_gastrointestinal_hemorrhage2.04956743
23MP0002063_abnormal_learning/memory/cond2.04151182
24MP0009697_abnormal_copulation2.03069740
25MP0001270_distended_abdomen2.02749902
26MP0005423_abnormal_somatic_nervous1.99617746
27MP0002064_seizures1.93790563
28MP0004233_abnormal_muscle_weight1.91772403
29MP0003329_amyloid_beta_deposits1.89064374
30MP0009745_abnormal_behavioral_response1.83685262
31MP0002909_abnormal_adrenal_gland1.82355314
32MP0003950_abnormal_plasma_membrane1.81289854
33MP0008569_lethality_at_weaning1.80805518
34MP0008961_abnormal_basal_metabolism1.79371575
35MP0004272_abnormal_basement_membrane1.76301875
36MP0002653_abnormal_ependyma_morphology1.75953701
37MP0005275_abnormal_skin_tensile1.74973643
38MP0004811_abnormal_neuron_physiology1.70262303
39MP0001905_abnormal_dopamine_level1.67274723
40MP0004084_abnormal_cardiac_muscle1.66095516
41MP0001968_abnormal_touch/_nociception1.65789157
42MP0009780_abnormal_chondrocyte_physiolo1.61620234
43MP0009046_muscle_twitch1.61223130
44MP0002734_abnormal_mechanical_nocicepti1.59512511
45MP0002282_abnormal_trachea_morphology1.58820030
46MP0000343_altered_response_to1.58189038
47MP0000537_abnormal_urethra_morphology1.57742040
48MP0003806_abnormal_nucleotide_metabolis1.57273645
49MP0010234_abnormal_vibrissa_follicle1.56122683
50MP0000778_abnormal_nervous_system1.54840119
51MP0000681_abnormal_thyroid_gland1.53033308
52MP0000955_abnormal_spinal_cord1.52795056
53MP0005084_abnormal_gallbladder_morpholo1.51216937
54MP0002733_abnormal_thermal_nociception1.50905294
55MP0002272_abnormal_nervous_system1.49673889
56MP0008260_abnormal_autophagy1.48774889
57MP0001984_abnormal_olfaction1.47435929
58MP0002572_abnormal_emotion/affect_behav1.45165596
59MP0005508_abnormal_skeleton_morphology1.44030401
60MP0003283_abnormal_digestive_organ1.44013723
61MP0001486_abnormal_startle_reflex1.42608196
62MP0004145_abnormal_muscle_electrophysio1.40865102
63MP0004885_abnormal_endolymph1.38952011
64MP0001879_abnormal_lymphatic_vessel1.38230692
65MP0002837_dystrophic_cardiac_calcinosis1.36444833
66MP0003122_maternal_imprinting1.35503626
67MP0004215_abnormal_myocardial_fiber1.35437443
68MP0003221_abnormal_cardiomyocyte_apopto1.34966096
69MP0001970_abnormal_pain_threshold1.32935227
70MP0005171_absent_coat_pigmentation1.30416120
71MP0003186_abnormal_redox_activity1.29359759
72MP0002184_abnormal_innervation1.27911268
73MP0002132_abnormal_respiratory_system1.27906371
74MP0000013_abnormal_adipose_tissue1.27846202
75MP0002295_abnormal_pulmonary_circulatio1.26783520
76MP0004087_abnormal_muscle_fiber1.23907210
77MP0005058_abnormal_lysosome_morphology1.23130592
78MP0001299_abnormal_eye_distance/1.21933851
79MP0004036_abnormal_muscle_relaxation1.20273995
80MP0003634_abnormal_glial_cell1.19581338
81MP0002067_abnormal_sensory_capabilities1.19117838
82MP0000747_muscle_weakness1.18676163
83MP0002882_abnormal_neuron_morphology1.18675596
84MP0000534_abnormal_ureter_morphology1.17562007
85MP0000733_abnormal_muscle_development1.15127813
86MP0001440_abnormal_grooming_behavior1.13683986
87MP0008995_early_reproductive_senescence1.13635197
88MP0002152_abnormal_brain_morphology1.13376698
89MP0003705_abnormal_hypodermis_morpholog1.13130393
90MP0005167_abnormal_blood-brain_barrier1.12007274
91MP0002233_abnormal_nose_morphology1.10999154
92MP0002736_abnormal_nociception_after1.09990816
93MP0006276_abnormal_autonomic_nervous1.08830322
94MP0002735_abnormal_chemical_nociception1.08552891
95MP0005451_abnormal_body_composition1.08436042
96MP0002557_abnormal_social/conspecific_i1.07867967
97MP0003300_gastrointestinal_ulcer1.07680612
98MP0004130_abnormal_muscle_cell1.06812768
99MP0002066_abnormal_motor_capabilities/c1.03430380
100MP0005257_abnormal_intraocular_pressure1.03290472
101MP0002089_abnormal_postnatal_growth/wei1.02019923
102MP0002822_catalepsy0.99753448
103MP0000163_abnormal_cartilage_morphology0.98862218
104MP0000920_abnormal_myelination0.98648524
105MP0001348_abnormal_lacrimal_gland0.98450968
106MP0004883_abnormal_blood_vessel0.98431051
107MP0003698_abnormal_male_reproductive0.98419067
108MP0009250_abnormal_appendicular_skeleto0.97799740
109MP0005164_abnormal_response_to0.97555979
110MP0003646_muscle_fatigue0.97357251
111MP0002234_abnormal_pharynx_morphology0.97277407
112MP0003633_abnormal_nervous_system0.96628499
113MP0000759_abnormal_skeletal_muscle0.96625161
114MP0005386_behavior/neurological_phenoty0.95742317
115MP0004924_abnormal_behavior0.95742317
116MP0003861_abnormal_nervous_system0.95038079
117MP0003786_premature_aging0.94124705
118MP0005187_abnormal_penis_morphology0.93723814
119MP0003137_abnormal_impulse_conducting0.93669569
120MP0003828_pulmonary_edema0.93338770
121MP0005076_abnormal_cell_differentiation0.92883758
122MP0000003_abnormal_adipose_tissue0.92467811
123MP0005253_abnormal_eye_physiology0.91198732
124MP0003123_paternal_imprinting0.90632340
125MP0004085_abnormal_heartbeat0.89696154
126MP0003091_abnormal_cell_migration0.89486543
127MP0003191_abnormal_cellular_cholesterol0.89270201
128MP0002106_abnormal_muscle_physiology0.88312843
129MP0003385_abnormal_body_wall0.86253150
130MP0006072_abnormal_retinal_apoptosis0.84878655
131MP0000749_muscle_degeneration0.84413970
132MP0004185_abnormal_adipocyte_glucose0.83828178
133MP0006036_abnormal_mitochondrial_physio0.83798724
134MP0005330_cardiomyopathy0.82957429
135MP0010630_abnormal_cardiac_muscle0.81379676
136MP0001958_emphysema0.80856479
137MP0004510_myositis0.80723131
138MP0002332_abnormal_exercise_endurance0.80474509
139MP0005620_abnormal_muscle_contractility0.79834630
140MP0003755_abnormal_palate_morphology0.79655181
141MP0003787_abnormal_imprinting0.79592212
142MP0002269_muscular_atrophy0.79209143
143MP0003631_nervous_system_phenotype0.79168043
144MP0004484_altered_response_of0.79065567
145MP0001986_abnormal_taste_sensitivity0.78750878
146MP0003315_abnormal_perineum_morphology0.76875305
147MP0002972_abnormal_cardiac_muscle0.76506689
148MP0002751_abnormal_autonomic_nervous0.74744346
149MP0005595_abnormal_vascular_smooth0.73691592
150MP0005375_adipose_tissue_phenotype0.73283793
151MP0004134_abnormal_chest_morphology0.72932989
152MP0000750_abnormal_muscle_regeneration0.72698703
153MP0005369_muscle_phenotype0.72342517
154MP0001943_abnormal_respiration0.72108512
155MP0005165_increased_susceptibility_to0.70862331
156MP0002108_abnormal_muscle_morphology0.70061822
157MP0001243_abnormal_dermal_layer0.69624238
158MP0001502_abnormal_circadian_rhythm0.69621510
159MP0001501_abnormal_sleep_pattern0.68698867
160MP0002249_abnormal_larynx_morphology0.68559721
161MP0003045_fibrosis0.68182471
162MP0000428_abnormal_craniofacial_morphol0.68033196
163MP0005388_respiratory_system_phenotype0.67750938
164MP0002133_abnormal_respiratory_system0.67750938
165MP0001188_hyperpigmentation0.67124036
166MP0005390_skeleton_phenotype0.65797730
167MP0000639_abnormal_adrenal_gland0.64843988
168MP0002896_abnormal_bone_mineralization0.62835375
169MP0000767_abnormal_smooth_muscle0.62667763
170MP0003656_abnormal_erythrocyte_physiolo0.62308226
171MP0003011_delayed_dark_adaptation0.60306726
172MP0001764_abnormal_homeostasis0.60032563
173MP0002177_abnormal_outer_ear0.59698744
174MP0002113_abnormal_skeleton_development0.59237522

Predicted human phenotypes

RankGene SetZ-score
1Follicular hyperkeratosis (HP:0007502)3.91663887
2Myokymia (HP:0002411)3.75964462
3Protrusio acetabuli (HP:0003179)3.66803136
4Premature rupture of membranes (HP:0001788)3.57808341
5Neonatal respiratory distress (HP:0002643)3.49782892
6Retinal dysplasia (HP:0007973)3.42028517
7Ankle contracture (HP:0006466)3.35458628
8Hyperacusis (HP:0010780)3.06132421
9Split foot (HP:0001839)3.05731118
10Atrophy/Degeneration involving motor neurons (HP:0007373)3.04688227
11Action tremor (HP:0002345)3.04265209
12Visual hallucinations (HP:0002367)3.00355544
13Insomnia (HP:0100785)2.99074976
14Megalencephaly (HP:0001355)2.94153839
15Supranuclear gaze palsy (HP:0000605)2.84006957
16Increased serum pyruvate (HP:0003542)2.81224083
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.72040792
18Decreased activity of mitochondrial respiratory chain (HP:0008972)2.72040792
19Spinal rigidity (HP:0003306)2.69782165
20Postnatal microcephaly (HP:0005484)2.69610295
21Bundle branch block (HP:0011710)2.69254072
22Neoplasm of the heart (HP:0100544)2.66804948
23Insidious onset (HP:0003587)2.65834719
24Termporal pattern (HP:0011008)2.65834719
25Gait imbalance (HP:0002141)2.61438044
26Shoulder girdle muscle weakness (HP:0003547)2.57855982
27Focal seizures (HP:0007359)2.55172316
28Failure to thrive in infancy (HP:0001531)2.55143462
29Urinary urgency (HP:0000012)2.54834751
30Congenital primary aphakia (HP:0007707)2.49368346
31Ankle clonus (HP:0011448)2.47162992
32Mutism (HP:0002300)2.46354650
33Papilledema (HP:0001085)2.46030569
34Hypercortisolism (HP:0001578)2.45242312
35Nephrogenic diabetes insipidus (HP:0009806)2.44335330
36Depression (HP:0000716)2.44247046
37Abnormality of the motor neurons (HP:0002450)2.43915441
38Abnormal neuron morphology (HP:0012757)2.43915441
39Heterochromia iridis (HP:0001100)2.42818561
40Overriding aorta (HP:0002623)2.38934257
41Reduced antithrombin III activity (HP:0001976)2.38223973
42Pointed chin (HP:0000307)2.37955852
43Delusions (HP:0000746)2.37871118
44Difficulty running (HP:0009046)2.36803479
45Vertebral compression fractures (HP:0002953)2.36764411
46Abnormal protein glycosylation (HP:0012346)2.36708422
47Abnormal glycosylation (HP:0012345)2.36708422
48Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.36708422
49Abnormal protein N-linked glycosylation (HP:0012347)2.36708422
50Cerebral hypomyelination (HP:0006808)2.35121334
51Limb-girdle muscle weakness (HP:0003325)2.33976025
52Focal motor seizures (HP:0011153)2.33921629
53Axonal loss (HP:0003447)2.33827121
54Abnormality of the lower motor neuron (HP:0002366)2.28662550
55Abnormality of the musculature of the pelvis (HP:0001469)2.28212686
56Abnormality of the hip-girdle musculature (HP:0001445)2.28212686
57Abnormality of dentin (HP:0010299)2.25538934
58Autoamputation (HP:0001218)2.25485884
59Wrist flexion contracture (HP:0001239)2.24930844
60Medial flaring of the eyebrow (HP:0010747)2.24763002
61Abnormality of glycolysis (HP:0004366)2.24678353
62Absent/shortened dynein arms (HP:0200106)2.24361919
63Dynein arm defect of respiratory motile cilia (HP:0012255)2.24361919
64Metaphyseal dysplasia (HP:0100255)2.23724750
65Decreased skull ossification (HP:0004331)2.22995734
66Aortic aneurysm (HP:0004942)2.21688913
67Spastic paraparesis (HP:0002313)2.19562319
68Aortic dissection (HP:0002647)2.18479085
69Renal duplication (HP:0000075)2.18419353
70Progressive cerebellar ataxia (HP:0002073)2.18340230
71Ventricular fibrillation (HP:0001663)2.18250220
72Elfin facies (HP:0004428)2.17625790
73Buphthalmos (HP:0000557)2.17308962
74Macroorchidism (HP:0000053)2.14843671
75Amyotrophic lateral sclerosis (HP:0007354)2.14332448
76Vascular tortuosity (HP:0004948)2.14209438
77Abnormality of skull ossification (HP:0002703)2.14181213
78Thyroid-stimulating hormone excess (HP:0002925)2.12256326
79Impaired vibration sensation in the lower limbs (HP:0002166)2.08907014
80Sudden death (HP:0001699)2.07140175
81Rapidly progressive (HP:0003678)2.06574598
82Exercise-induced myalgia (HP:0003738)2.06281581
83Delayed gross motor development (HP:0002194)2.04776755
84Cerebral aneurysm (HP:0004944)2.03607600
85Cervical subluxation (HP:0003308)2.02425839
86Cortical dysplasia (HP:0002539)2.02417452
87Exercise-induced muscle cramps (HP:0003710)2.01441920
88Neck muscle weakness (HP:0000467)2.01383905
89Cerebral inclusion bodies (HP:0100314)2.00979843
90Annular pancreas (HP:0001734)2.00777874
91Hand muscle atrophy (HP:0009130)2.00466092
92Increased variability in muscle fiber diameter (HP:0003557)1.99035446
93Rimmed vacuoles (HP:0003805)1.97275562
94Truncal ataxia (HP:0002078)1.97053977
95Nuclear cataract (HP:0100018)1.95473273
96Hyporeflexia of lower limbs (HP:0002600)1.95464061
97Ankyloglossia (HP:0010296)1.94684341
98Atonic seizures (HP:0010819)1.93398672
99Shallow orbits (HP:0000586)1.93149550
100Deep palmar crease (HP:0006191)1.92983256
101Recurrent corneal erosions (HP:0000495)1.92975913
102Wormian bones (HP:0002645)1.92882733
103Achilles tendon contracture (HP:0001771)1.91442980
104Neoplasm of the peripheral nervous system (HP:0100007)1.90763270
105Dysdiadochokinesis (HP:0002075)1.90590460
106Bowel diverticulosis (HP:0005222)1.90250166
107Hemiplegia (HP:0002301)1.89988064
108Pheochromocytoma (HP:0002666)1.88762426
109Bladder diverticulum (HP:0000015)1.88736974
110Emotional lability (HP:0000712)1.86755468
111Hydroureter (HP:0000072)1.86336499
112Abnormality of oral frenula (HP:0000190)1.84709227
113Abnormal mitochondria in muscle tissue (HP:0008316)1.83410291
114Urinary bladder sphincter dysfunction (HP:0002839)1.83125998
115Flat cornea (HP:0007720)1.82513467
116Poor eye contact (HP:0000817)1.82108023
117Myotonia (HP:0002486)1.81784436
118Hypoventilation (HP:0002791)1.81474718
119Acute necrotizing encephalopathy (HP:0006965)1.81448281
120Dysmetric saccades (HP:0000641)1.80406659
121Scapular winging (HP:0003691)1.80070023
122Lower limb muscle weakness (HP:0007340)1.79696530
123Renovascular hypertension (HP:0100817)1.79307117
124Hepatocellular necrosis (HP:0001404)1.79051998
125Upper limb amyotrophy (HP:0009129)1.78249967
126Distal upper limb amyotrophy (HP:0007149)1.78249967
127Slender build (HP:0001533)1.78215661
128Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.78126576
129Broad metatarsal (HP:0001783)1.77643166
130Resting tremor (HP:0002322)1.77462868
131Peripheral hypomyelination (HP:0007182)1.77375743
132Aplasia/Hypoplasia of the lens (HP:0008063)1.76511705
133Hypoplasia of the brainstem (HP:0002365)1.76224020
134Aplasia/Hypoplasia of the brainstem (HP:0007362)1.76224020
135Postural instability (HP:0002172)1.76086000
136Aplasia/Hypoplasia of the clavicles (HP:0006710)1.75628148
137Impaired social interactions (HP:0000735)1.75616039
138Abnormal social behavior (HP:0012433)1.75616039
139Distal arthrogryposis (HP:0005684)1.75602503
140Cholelithiasis (HP:0001081)1.75588115
141Apathy (HP:0000741)1.75243590
142Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.75059037
143Hypoplastic left heart (HP:0004383)1.74921522
144Dysmetria (HP:0001310)1.74684708
145Palpebral edema (HP:0100540)1.74592359
146Menstrual irregularities (HP:0000858)1.74522390
147Difficulty climbing stairs (HP:0003551)1.74503311
148Genetic anticipation (HP:0003743)1.73631362
149Hemiparesis (HP:0001269)1.73582743
150Neurofibrillary tangles (HP:0002185)1.73449042
151Hepatic necrosis (HP:0002605)1.73021734
152Spastic gait (HP:0002064)1.71436364
153Limb-girdle muscle atrophy (HP:0003797)1.71388395
154Amblyopia (HP:0000646)1.71014414
155Abnormality of the metopic suture (HP:0005556)1.70952460
156Sacral dimple (HP:0000960)1.70936205
157Congenital glaucoma (HP:0001087)1.70448016
158Back pain (HP:0003418)1.70193039
159Redundant skin (HP:0001582)1.69214675
160Abnormal hemoglobin (HP:0011902)1.69065550
161Intention tremor (HP:0002080)1.68501624
162Abnormality of skeletal muscle fiber size (HP:0012084)1.67985677
163Heterotopia (HP:0002282)1.67411318
164Decreased testicular size (HP:0008734)1.66673974
165Patchy hypopigmentation of hair (HP:0011365)1.66561162
166Pelvic girdle muscle weakness (HP:0003749)1.65184012
167Opisthotonus (HP:0002179)1.65124946
168Polyphagia (HP:0002591)1.64865762
169Diminished motivation (HP:0000745)1.64794388
170Brushfield spots (HP:0001088)1.64781415
171Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.64735227
172Atelectasis (HP:0100750)1.64461162
173Joint stiffness (HP:0001387)1.64366702
174Unsteady gait (HP:0002317)1.64272552
175Intellectual disability, profound (HP:0002187)1.64031465
176Broad distal phalanx of finger (HP:0009836)1.63464100
177Degeneration of anterior horn cells (HP:0002398)1.62601429
178Abnormality of the anterior horn cell (HP:0006802)1.62601429
179Respiratory insufficiency due to muscle weakness (HP:0002747)1.62260897
180Beaking of vertebral bodies (HP:0004568)1.61821601
1813-Methylglutaconic aciduria (HP:0003535)1.61762725
182Absent speech (HP:0001344)1.61503593
183Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.61318089
184Short 4th metacarpal (HP:0010044)1.61318089
185Asymmetric septal hypertrophy (HP:0001670)1.61109027
186Lower limb amyotrophy (HP:0007210)1.60945289
187Absence seizures (HP:0002121)1.59923908
188Generalized hypotonia (HP:0001290)1.59457466
189Abnormality of the nasal mucosa (HP:0000433)1.59422926

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCR4.02203854
2TRIB33.66030114
3PRKD33.47899979
4TRIM283.34084848
5MAP4K23.26908359
6MAP3K92.53507821
7PKN22.52271987
8PAK62.45757787
9MAP2K72.44110392
10KSR22.40123169
11TESK12.38694420
12ICK2.37475289
13TYRO32.36638729
14SIK32.24790300
15CSNK1G32.20476367
16RPS6KA42.19549282
17NTRK32.16335839
18MYLK2.13948301
19PDK32.12251790
20PDK42.12251790
21ERBB32.11568167
22LMTK22.10191982
23MARK12.07823034
24EEF2K1.98581667
25PINK11.96914084
26CSNK1A1L1.91029352
27BCKDK1.87692458
28MINK11.80022928
29CSNK1G11.79373340
30PHKG21.79060688
31PHKG11.79060688
32CAMKK11.77904559
33RIPK11.76170818
34NTRK11.70032429
35ARAF1.68299343
36PIM21.61639403
37NTRK21.61638232
38PDGFRA1.57230269
39STK381.55859224
40TTN1.53208504
41MAP3K121.52273696
42UHMK11.52259333
43KSR11.52220243
44TAOK11.43749595
45SCYL21.42385649
46MAP3K41.38919844
47MAP3K101.38559873
48ALK1.36641477
49BMPR21.34648489
50CCNB11.32844799
51RET1.32602999
52DMPK1.24873997
53DYRK31.24233977
54CLK11.22794092
55DYRK21.21376434
56PAK31.19507349
57LATS21.18480898
58SRPK11.16155607
59LIMK11.14376927
60FLT31.12436528
61PRKCH1.08794812
62PTK2B1.07525691
63EPHA31.07383591
64SIK21.06804357
65MOS1.05734638
66EPHA41.05246785
67CDK51.05077333
68TIE11.04978533
69PTK61.02676242
70TESK21.02184741
71LRRK21.01373498
72MAP3K61.01168091
73MAP3K21.00559180
74WNK11.00124993
75DDR20.97683627
76STK390.97650693
77WNK40.97092512
78ILK0.96394155
79CDK140.90594023
80TAOK20.89948708
81DAPK20.89231439
82PDK20.87398144
83CDK150.86326772
84MAP3K50.85076924
85MARK20.84211427
86PDK10.83918493
87EIF2AK30.81550018
88CDK180.81511729
89DAPK10.81238451
90KDR0.79361922
91STK38L0.78777262
92ROCK20.78499559
93CDK11A0.77355977
94PDGFRB0.76563527
95NEK10.75493030
96CDK190.73733872
97PNCK0.72661472
98BMX0.72573975
99CAMK1G0.71211071
100STK110.71058593
101PLK20.70990320
102NEK90.68790113
103WNK30.67007654
104PDPK10.66865928
105DYRK1B0.65815844
106PTK20.65128906
107PAK20.65048220
108GRK70.62721836
109CDK30.60630458
110CDC42BPA0.59468571
111PRKD10.58600998
112PRKCE0.55351946
113ROCK10.54682042
114PAK40.52594092
115FES0.52203465
116MAP3K70.50981203
117CSNK1G20.49511400
118BRSK10.49382201
119MAP2K40.48644793
120DYRK1A0.47724509
121STK160.47410626
122DAPK30.46674764
123FYN0.46340725
124TBK10.46063748
125CAMK2G0.45024372
126EPHB20.44390275
127ABL20.44299467
128MAP3K10.43610884
129TGFBR20.41976382
130ERBB40.41737856
131FGFR20.41600203
132FGFR10.40137643
133CAMK2B0.40133460
134EPHB10.40089470
135MAPK130.37690294
136HIPK20.37519937
137CSF1R0.37267636
138PASK0.35975542
139RAF10.35800835
140MTOR0.35698044
141EIF2AK10.34828853
142PRKD20.34676266
143SRC0.34595573
144PRKCG0.33200243
145CSNK1A10.32664018
146MAPK70.31139375
147RPS6KA30.31120219
148CAMK10.31109908
149RPS6KA20.31083916
150GRK50.30570714
151CDK60.29221755
152PAK10.29057750
153CAMK2A0.28863868
154PRPF4B0.27085481

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.88516579
2Proteasome_Homo sapiens_hsa030503.22691362
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.15418051
4Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.04048745
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.94566753
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.89124437
7Vibrio cholerae infection_Homo sapiens_hsa051102.68675090
8Fatty acid elongation_Homo sapiens_hsa000622.56460641
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.38957960
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22383498
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.06007654
12Collecting duct acid secretion_Homo sapiens_hsa049662.04589798
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.02775333
14Shigellosis_Homo sapiens_hsa051311.98512492
15Long-term potentiation_Homo sapiens_hsa047201.96936964
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.92441281
17Oxidative phosphorylation_Homo sapiens_hsa001901.90906285
18Parkinsons disease_Homo sapiens_hsa050121.86521767
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.84231325
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.83476798
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.83035756
22Synaptic vesicle cycle_Homo sapiens_hsa047211.82415666
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74971781
24Gastric acid secretion_Homo sapiens_hsa049711.67222813
25Circadian entrainment_Homo sapiens_hsa047131.66770252
26Olfactory transduction_Homo sapiens_hsa047401.62201634
27Salmonella infection_Homo sapiens_hsa051321.56474832
28Dopaminergic synapse_Homo sapiens_hsa047281.52784763
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51965480
30Amphetamine addiction_Homo sapiens_hsa050311.51320694
31GABAergic synapse_Homo sapiens_hsa047271.50369588
32Glutamatergic synapse_Homo sapiens_hsa047241.49587044
33Glioma_Homo sapiens_hsa052141.45515457
34Phagosome_Homo sapiens_hsa041451.44447836
35Insulin secretion_Homo sapiens_hsa049111.44244410
36Salivary secretion_Homo sapiens_hsa049701.43283097
37Cholinergic synapse_Homo sapiens_hsa047251.40870898
38Estrogen signaling pathway_Homo sapiens_hsa049151.40825958
39Regulation of autophagy_Homo sapiens_hsa041401.40341979
40Oxytocin signaling pathway_Homo sapiens_hsa049211.40051899
41Gap junction_Homo sapiens_hsa045401.39963802
42Steroid biosynthesis_Homo sapiens_hsa001001.38409207
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37474492
44VEGF signaling pathway_Homo sapiens_hsa043701.37383734
45Morphine addiction_Homo sapiens_hsa050321.37099969
46Dorso-ventral axis formation_Homo sapiens_hsa043201.36871137
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35313252
48Butanoate metabolism_Homo sapiens_hsa006501.32069800
49Renin secretion_Homo sapiens_hsa049241.31525278
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.27924383
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.26037523
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.25536818
53Dilated cardiomyopathy_Homo sapiens_hsa054141.25385701
54Nicotine addiction_Homo sapiens_hsa050331.24719593
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22546827
56Peroxisome_Homo sapiens_hsa041461.22420145
57Axon guidance_Homo sapiens_hsa043601.22020996
58GnRH signaling pathway_Homo sapiens_hsa049121.21173919
59Sulfur metabolism_Homo sapiens_hsa009201.19984376
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18227689
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17198732
62Circadian rhythm_Homo sapiens_hsa047101.16362232
63Cardiac muscle contraction_Homo sapiens_hsa042601.16179804
64Long-term depression_Homo sapiens_hsa047301.15411901
65Carbon metabolism_Homo sapiens_hsa012001.15208310
66Neurotrophin signaling pathway_Homo sapiens_hsa047221.15169628
67cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13962780
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13927855
69Oocyte meiosis_Homo sapiens_hsa041141.13823610
70Cocaine addiction_Homo sapiens_hsa050301.13746109
71Renal cell carcinoma_Homo sapiens_hsa052111.13636616
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09111469
73Phospholipase D signaling pathway_Homo sapiens_hsa040721.08991270
74Melanogenesis_Homo sapiens_hsa049161.08723770
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.08587989
76Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07179921
77Biosynthesis of amino acids_Homo sapiens_hsa012301.06778629
78Alzheimers disease_Homo sapiens_hsa050101.05841681
79mTOR signaling pathway_Homo sapiens_hsa041501.05225124
80Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04850991
81Type II diabetes mellitus_Homo sapiens_hsa049301.03683888
82cAMP signaling pathway_Homo sapiens_hsa040241.02600389
83Endocytosis_Homo sapiens_hsa041441.02269076
84Endometrial cancer_Homo sapiens_hsa052131.01620407
85Chronic myeloid leukemia_Homo sapiens_hsa052200.99737036
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99576232
87Propanoate metabolism_Homo sapiens_hsa006400.99144114
88ErbB signaling pathway_Homo sapiens_hsa040120.99003630
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98874012
90Pertussis_Homo sapiens_hsa051330.98792049
91beta-Alanine metabolism_Homo sapiens_hsa004100.94513268
92Non-small cell lung cancer_Homo sapiens_hsa052230.93793527
93Colorectal cancer_Homo sapiens_hsa052100.93552252
94Focal adhesion_Homo sapiens_hsa045100.93333788
95Calcium signaling pathway_Homo sapiens_hsa040200.93208181
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92863354
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92805536
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92489205
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92269062
100Glutathione metabolism_Homo sapiens_hsa004800.91695360
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.91601364
102Base excision repair_Homo sapiens_hsa034100.90641025
103Rheumatoid arthritis_Homo sapiens_hsa053230.90631202
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89580691
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88316398
106Glucagon signaling pathway_Homo sapiens_hsa049220.87840245
107Tight junction_Homo sapiens_hsa045300.87606484
108Hedgehog signaling pathway_Homo sapiens_hsa043400.87165898
109Huntingtons disease_Homo sapiens_hsa050160.85224879
110Proteoglycans in cancer_Homo sapiens_hsa052050.84992767
111MAPK signaling pathway_Homo sapiens_hsa040100.84203119
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.84006715
113Viral myocarditis_Homo sapiens_hsa054160.82325929
114Rap1 signaling pathway_Homo sapiens_hsa040150.80860502
115Thyroid hormone synthesis_Homo sapiens_hsa049180.79658616
116Hippo signaling pathway_Homo sapiens_hsa043900.79402375
117Wnt signaling pathway_Homo sapiens_hsa043100.79271901
118Insulin signaling pathway_Homo sapiens_hsa049100.78656416
119Pancreatic secretion_Homo sapiens_hsa049720.78554244
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78332979
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77585598
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76685060
123Lysosome_Homo sapiens_hsa041420.76596439
124Taste transduction_Homo sapiens_hsa047420.76229001
125Choline metabolism in cancer_Homo sapiens_hsa052310.75072960
126Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74262197
127Pyruvate metabolism_Homo sapiens_hsa006200.74045384
128Pancreatic cancer_Homo sapiens_hsa052120.73885491
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73130568
130Fatty acid metabolism_Homo sapiens_hsa012120.72852747
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72464224
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72450799
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72301538
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.72196689
135Alcoholism_Homo sapiens_hsa050340.71913295
136T cell receptor signaling pathway_Homo sapiens_hsa046600.71717718
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70404597
138Serotonergic synapse_Homo sapiens_hsa047260.69880736
139Spliceosome_Homo sapiens_hsa030400.69356252
140Nitrogen metabolism_Homo sapiens_hsa009100.66762407
141Platelet activation_Homo sapiens_hsa046110.66540961
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66255092
143Legionellosis_Homo sapiens_hsa051340.66010555
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65715353
145B cell receptor signaling pathway_Homo sapiens_hsa046620.64677683
146Ras signaling pathway_Homo sapiens_hsa040140.64258724
147Adherens junction_Homo sapiens_hsa045200.62069375
148Bladder cancer_Homo sapiens_hsa052190.60063907
149Sulfur relay system_Homo sapiens_hsa041220.59880542
150Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59764238
151Pyrimidine metabolism_Homo sapiens_hsa002400.59679231
152RNA polymerase_Homo sapiens_hsa030200.58621530
153AMPK signaling pathway_Homo sapiens_hsa041520.58591613
154Basal cell carcinoma_Homo sapiens_hsa052170.57424940
155Basal transcription factors_Homo sapiens_hsa030220.52958390
156Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52849285
157ECM-receptor interaction_Homo sapiens_hsa045120.52356473
158Arginine and proline metabolism_Homo sapiens_hsa003300.50872266
159Folate biosynthesis_Homo sapiens_hsa007900.50872250
160Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50142437
161Cysteine and methionine metabolism_Homo sapiens_hsa002700.47336631
162Metabolic pathways_Homo sapiens_hsa011000.45672352
163Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42880223
164Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41228427
165Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40152513
166Primary bile acid biosynthesis_Homo sapiens_hsa001200.38656200
167Nucleotide excision repair_Homo sapiens_hsa034200.37572631
168Prion diseases_Homo sapiens_hsa050200.31424728
169N-Glycan biosynthesis_Homo sapiens_hsa005100.30322416
170Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29445458
171PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29290375
172Malaria_Homo sapiens_hsa051440.28934111
173TGF-beta signaling pathway_Homo sapiens_hsa043500.27363934
174Drug metabolism - other enzymes_Homo sapiens_hsa009830.24917587

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