ARL4D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. Mutations in this gene have been associated with Bardet-Biedl syndrome (BBS). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.57883290
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.57883290
3L-phenylalanine metabolic process (GO:0006558)6.43381969
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.43381969
5aromatic amino acid family catabolic process (GO:0009074)5.50040337
6regulation of protein activation cascade (GO:2000257)5.19165089
7regulation of complement activation (GO:0030449)5.03745317
8kynurenine metabolic process (GO:0070189)4.88660346
9negative regulation of fibrinolysis (GO:0051918)4.83155743
10negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.79224126
11bile acid biosynthetic process (GO:0006699)4.76960551
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.74106743
13tryptophan catabolic process (GO:0006569)4.70397744
14indole-containing compound catabolic process (GO:0042436)4.70397744
15indolalkylamine catabolic process (GO:0046218)4.70397744
16complement activation, alternative pathway (GO:0006957)4.63044470
17urea metabolic process (GO:0019627)4.58695287
18urea cycle (GO:0000050)4.58695287
19regulation of fibrinolysis (GO:0051917)4.53085235
20high-density lipoprotein particle remodeling (GO:0034375)4.44645524
21pyrimidine nucleobase catabolic process (GO:0006208)4.44480999
22tryptophan metabolic process (GO:0006568)4.40049297
23negative regulation of protein activation cascade (GO:2000258)4.39448166
24protein carboxylation (GO:0018214)4.36314761
25peptidyl-glutamic acid carboxylation (GO:0017187)4.36314761
26cysteine metabolic process (GO:0006534)4.32633678
27alpha-linolenic acid metabolic process (GO:0036109)4.29475392
28sulfur amino acid catabolic process (GO:0000098)4.26603401
29regulation of retinoic acid receptor signaling pathway (GO:0048385)4.25587360
30glyoxylate metabolic process (GO:0046487)4.18742437
31serine family amino acid catabolic process (GO:0009071)4.16521800
32nitrogen cycle metabolic process (GO:0071941)4.16325779
33lysine metabolic process (GO:0006553)4.15317529
34lysine catabolic process (GO:0006554)4.15317529
35regulation of bile acid biosynthetic process (GO:0070857)4.14985120
36negative regulation of complement activation (GO:0045916)4.06481879
37glutamate metabolic process (GO:0006536)4.02418154
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.00980948
39homocysteine metabolic process (GO:0050667)3.98737205
40bile acid metabolic process (GO:0008206)3.94446376
41acylglycerol homeostasis (GO:0055090)3.91785822
42triglyceride homeostasis (GO:0070328)3.91785822
43regulation of triglyceride catabolic process (GO:0010896)3.91673755
44aromatic amino acid family metabolic process (GO:0009072)3.87531672
45tyrosine metabolic process (GO:0006570)3.86953635
46alpha-amino acid catabolic process (GO:1901606)3.85492994
47regulation of cholesterol homeostasis (GO:2000188)3.83404223
48reverse cholesterol transport (GO:0043691)3.82475085
49negative regulation of lipase activity (GO:0060192)3.80157146
50substrate-independent telencephalic tangential migration (GO:0021826)3.79067098
51substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.79067098
52ganglion development (GO:0061548)3.77969237
53fibrinolysis (GO:0042730)3.76620186
54phospholipid efflux (GO:0033700)3.70829073
55acrosome reaction (GO:0007340)3.64629566
56amino-acid betaine metabolic process (GO:0006577)3.64123855
57negative regulation of sterol transport (GO:0032372)3.56995924
58negative regulation of cholesterol transport (GO:0032375)3.56995924
59regulation of cholesterol esterification (GO:0010872)3.54410651
60cellular amino acid catabolic process (GO:0009063)3.54350392
61bile acid and bile salt transport (GO:0015721)3.50768203
62plasma lipoprotein particle remodeling (GO:0034369)3.50538165
63protein-lipid complex remodeling (GO:0034368)3.50538165
64macromolecular complex remodeling (GO:0034367)3.50538165
65drug catabolic process (GO:0042737)3.50056988
66cytolysis (GO:0019835)3.49904351
67cellular modified amino acid catabolic process (GO:0042219)3.48024484
68behavioral response to nicotine (GO:0035095)3.44170094
69dicarboxylic acid biosynthetic process (GO:0043650)3.43691025
70arginine metabolic process (GO:0006525)3.42920355
71positive regulation of mitochondrial fission (GO:0090141)3.39076331
72nucleobase catabolic process (GO:0046113)3.36219994
73plasma lipoprotein particle clearance (GO:0034381)3.35740497
74cholesterol efflux (GO:0033344)3.32772906
75aspartate family amino acid catabolic process (GO:0009068)3.26412810
76ethanol oxidation (GO:0006069)3.25232986
77complement activation, classical pathway (GO:0006958)3.24418848
78cellular ketone body metabolic process (GO:0046950)3.24163250
79positive regulation of lipoprotein lipase activity (GO:0051006)3.23808171
80positive regulation of triglyceride lipase activity (GO:0061365)3.23808171
81benzene-containing compound metabolic process (GO:0042537)3.23693098
82coenzyme catabolic process (GO:0009109)3.22217739
83serine family amino acid metabolic process (GO:0009069)3.15889293
84dicarboxylic acid catabolic process (GO:0043649)3.14589694
85exogenous drug catabolic process (GO:0042738)3.13321390
86complement activation (GO:0006956)3.12787829
87head development (GO:0060322)3.10856541
88indolalkylamine metabolic process (GO:0006586)3.10359037
89cellular biogenic amine catabolic process (GO:0042402)3.09866139
90amine catabolic process (GO:0009310)3.09866139
91glycine metabolic process (GO:0006544)3.06794380
92L-serine transport (GO:0015825)3.06392927
93response to mercury ion (GO:0046689)3.05455413
942-oxoglutarate metabolic process (GO:0006103)3.05181201
95blood coagulation, intrinsic pathway (GO:0007597)3.05079093
96histone H3-K9 demethylation (GO:0033169)3.04727945
97urate metabolic process (GO:0046415)3.02418581
98protein activation cascade (GO:0072376)3.02062778
99organic acid catabolic process (GO:0016054)3.01599626
100carboxylic acid catabolic process (GO:0046395)3.01599626
101cholesterol homeostasis (GO:0042632)2.99084845
102positive regulation of fatty acid beta-oxidation (GO:0032000)2.97915235
103negative regulation of humoral immune response (GO:0002921)2.97831604
104positive regulation of lipid catabolic process (GO:0050996)2.95589737
105plasma lipoprotein particle assembly (GO:0034377)2.95470149
106forebrain neuron differentiation (GO:0021879)2.93854327
107sterol homeostasis (GO:0055092)2.93845019
108cerebral cortex radially oriented cell migration (GO:0021799)2.93511607
109drug transmembrane transport (GO:0006855)2.91719906
110limb bud formation (GO:0060174)2.90765043
111glycerophospholipid catabolic process (GO:0046475)2.90664230
112opsonization (GO:0008228)2.90304333
113protein import into peroxisome matrix (GO:0016558)2.89566258
114epoxygenase P450 pathway (GO:0019373)2.89047035
115phospholipid homeostasis (GO:0055091)2.88730866
116positive regulation of gastrulation (GO:2000543)2.87681283
117cellular glucuronidation (GO:0052695)2.86756085
118serine family amino acid biosynthetic process (GO:0009070)2.85205655
119protein localization to synapse (GO:0035418)2.78745736
120neuron recognition (GO:0008038)2.76285954
121olfactory bulb development (GO:0021772)2.75955943
122protein polyglutamylation (GO:0018095)2.73036239
123regulation of cardioblast differentiation (GO:0051890)2.72145346
124calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.71268068
125cardiac right ventricle morphogenesis (GO:0003215)2.70432447
126neurofilament cytoskeleton organization (GO:0060052)2.68510883
127cell migration in hindbrain (GO:0021535)2.66451179
128postsynaptic membrane organization (GO:0001941)2.62817888
129binding of sperm to zona pellucida (GO:0007339)2.60882318
130endoderm formation (GO:0001706)2.60045299
131axonal fasciculation (GO:0007413)2.58814469
132establishment of mitochondrion localization (GO:0051654)2.56953884
133outer ear morphogenesis (GO:0042473)2.56837071
134negative regulation of transcription regulatory region DNA binding (GO:2000678)2.54485329
135regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.53239764
136DNA integration (GO:0015074)2.52318677
137calcium ion-dependent exocytosis (GO:0017156)2.50969050
138regulation of mesoderm development (GO:2000380)2.50531206
139sympathetic nervous system development (GO:0048485)2.47502257
140chaperone-mediated protein transport (GO:0072321)2.47360552
141spinal cord development (GO:0021510)2.47277753
142positive regulation of male gonad development (GO:2000020)2.47058024
143multicellular organism reproduction (GO:0032504)2.46942071
144retinal ganglion cell axon guidance (GO:0031290)2.46539419
145presynaptic membrane organization (GO:0097090)2.45306727
146pyrimidine dimer repair (GO:0006290)2.45042657
147protein-cofactor linkage (GO:0018065)2.44591548
148gonadal mesoderm development (GO:0007506)2.43887179
149outflow tract septum morphogenesis (GO:0003148)2.43364306
150somite development (GO:0061053)2.43167683
151gamma-aminobutyric acid transport (GO:0015812)2.41036788
152retinal cone cell development (GO:0046549)2.39355985
153protein localization to cilium (GO:0061512)2.37263871
154sequestering of actin monomers (GO:0042989)2.37241233
155epithelial cilium movement (GO:0003351)2.37055445
156single strand break repair (GO:0000012)2.34702201
157nonmotile primary cilium assembly (GO:0035058)2.34239473
158acrosome assembly (GO:0001675)2.33024230
159synapse assembly (GO:0007416)2.32667265
160serine transport (GO:0032329)2.32629026
161ephrin receptor signaling pathway (GO:0048013)2.30896937
162regulation of male gonad development (GO:2000018)2.30694185
163negative regulation of oligodendrocyte differentiation (GO:0048715)2.29932775
164sperm-egg recognition (GO:0035036)2.27968217
165positive regulation of synapse assembly (GO:0051965)2.27919043
166neuron projection extension (GO:1990138)2.24314139
167positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.23981007
168presynaptic membrane assembly (GO:0097105)2.23656637
169axon extension (GO:0048675)2.23142033
170cornea development in camera-type eye (GO:0061303)2.22796524
171regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.22735133
172RNA localization (GO:0006403)2.22671645
173cellular response to BMP stimulus (GO:0071773)2.22075076
174response to BMP (GO:0071772)2.22075076
175cerebral cortex cell migration (GO:0021795)2.21026085
176de novo posttranslational protein folding (GO:0051084)2.20251400
177sterol biosynthetic process (GO:0016126)2.17633887
178somite rostral/caudal axis specification (GO:0032525)2.17122936
179cerebral cortex neuron differentiation (GO:0021895)2.16415265
180cholesterol biosynthetic process (GO:0006695)2.16029544
181negative regulation of synaptic transmission, GABAergic (GO:0032229)2.14992378
182reproduction (GO:0000003)2.14337921
183synaptic vesicle exocytosis (GO:0016079)2.13069376
184regulation of transcription involved in cell fate commitment (GO:0060850)2.12859531
185central nervous system projection neuron axonogenesis (GO:0021952)2.12744622
186neuron cell-cell adhesion (GO:0007158)2.12222779
187de novo protein folding (GO:0006458)2.10445259
188regulation of development, heterochronic (GO:0040034)2.10040190
189regulation of collateral sprouting (GO:0048670)2.09792182
190lens morphogenesis in camera-type eye (GO:0002089)2.09318921
191regulation of timing of cell differentiation (GO:0048505)2.09166278
192microtubule severing (GO:0051013)2.08372895
193intraciliary transport (GO:0042073)2.07628804
194spermatid nucleus differentiation (GO:0007289)2.07458091
195glycosphingolipid biosynthetic process (GO:0006688)2.07405224
196fat-soluble vitamin catabolic process (GO:0042363)2.06706678
197vitamin catabolic process (GO:0009111)2.06706678
198negative regulation of activin receptor signaling pathway (GO:0032926)2.03058699
199regulation of female gonad development (GO:2000194)2.02704738
200ubiquinone metabolic process (GO:0006743)2.02485681

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.26304442
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.02597826
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.17772133
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.70804808
5EZH2_22144423_ChIP-Seq_EOC_Human4.56791439
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.24417757
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.90350008
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.89291198
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.87365813
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.75887270
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.43983468
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.16717952
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.97171673
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.67052028
15CLOCK_20551151_ChIP-Seq_293T_Human2.56031606
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.44404213
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.24128173
18ZNF274_21170338_ChIP-Seq_K562_Hela2.21986363
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.18815451
20GBX2_23144817_ChIP-Seq_PC3_Human2.12268275
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08689524
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05863911
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05157679
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.94231299
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.92830123
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.92134727
27RNF2_27304074_Chip-Seq_NSC_Mouse1.91285809
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90693702
29IGF1R_20145208_ChIP-Seq_DFB_Human1.85821920
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.85444493
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74022455
32RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.72788146
33* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72118018
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.70890295
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.68694191
36TAF15_26573619_Chip-Seq_HEK293_Human1.67890300
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.66533693
38TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64094504
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62775706
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.59060932
41TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.58503967
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55886173
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54164618
44IRF1_19129219_ChIP-ChIP_H3396_Human1.49950681
45REST_21632747_ChIP-Seq_MESCs_Mouse1.47929197
46GATA1_22025678_ChIP-Seq_K562_Human1.47843340
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45991767
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.45304390
49* FOXA2_19822575_ChIP-Seq_HepG2_Human1.43905322
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.39768678
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.35063819
52LXR_22292898_ChIP-Seq_THP-1_Human1.34880800
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.32056784
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30745050
55P300_19829295_ChIP-Seq_ESCs_Human1.28022133
56ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27959675
57ZNF263_19887448_ChIP-Seq_K562_Human1.26050233
58VDR_22108803_ChIP-Seq_LS180_Human1.24628727
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23701503
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.20335872
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20063502
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18480185
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18090430
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17279717
65TRIM28_21343339_ChIP-Seq_HEK293_Human1.16967217
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16714305
67* ETS1_20019798_ChIP-Seq_JURKAT_Human1.16644617
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.12754629
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11700066
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11344122
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10810412
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10393902
73HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09430892
74KDM2B_26808549_Chip-Seq_K562_Human1.09364127
75CTCF_27219007_Chip-Seq_Bcells_Human1.08410126
76FUS_26573619_Chip-Seq_HEK293_Human1.08266041
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.07307750
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07249966
79RNF2_27304074_Chip-Seq_ESCs_Mouse1.07017142
80EST1_17652178_ChIP-ChIP_JURKAT_Human1.06774498
81FOXO3_23340844_ChIP-Seq_DLD1_Human1.06513128
82AR_25329375_ChIP-Seq_VCAP_Human1.05935156
83SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05882807
84RACK7_27058665_Chip-Seq_MCF-7_Human1.05029208
85SOX2_16153702_ChIP-ChIP_HESCs_Human1.04950794
86CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03963412
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03017717
88GATA1_26923725_Chip-Seq_HPCs_Mouse1.02940337
89PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02349954
90EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01721458
91RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01721458
92CREB1_26743006_Chip-Seq_LNCaP_Human1.00769177
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00610562
94ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00583265
95POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00400795
96DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00137391
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99371502
98CBP_20019798_ChIP-Seq_JUKART_Human0.99371502
99KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99337408
100TBX20_22328084_ChIP-Seq_HEART_Mouse0.97394928
101TBX20_22080862_ChIP-Seq_HEART_Mouse0.97394928
102ESR1_20079471_ChIP-ChIP_T-47D_Human0.97179418
103SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96572024
104RING1B_27294783_Chip-Seq_ESCs_Mouse0.95978000
105ELK3_25401928_ChIP-Seq_HUVEC_Human0.95031181
106PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94702691
107* HNF4A_19822575_ChIP-Seq_HepG2_Human0.94424390
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94116609
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93886471
110SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.93561009
111SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93111073
112SMAD4_21799915_ChIP-Seq_A2780_Human0.93086655
113OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91820405
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91757599
115SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.91647636
116ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91522632
117MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90760693
118EWS_26573619_Chip-Seq_HEK293_Human0.90129871
119ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88290430
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88242750
121GABP_19822575_ChIP-Seq_HepG2_Human0.88137844
122SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88104749
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87774793
124KLF5_20875108_ChIP-Seq_MESCs_Mouse0.86564495
125ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85781201
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.85324072
127FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84910357
128KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.84590563
129NCOR_22424771_ChIP-Seq_293T_Human0.84589760
130PIAS1_25552417_ChIP-Seq_VCAP_Human0.84461614
131MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.84244071
132EP300_21415370_ChIP-Seq_HL-1_Mouse0.83933410
133SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83838635
134SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.83543909
135KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83479858
136* SMAD3_21741376_ChIP-Seq_HESCs_Human0.82813685
137NANOG_16153702_ChIP-ChIP_HESCs_Human0.82776415
138CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82623192
139RUNX2_22187159_ChIP-Seq_PCA_Human0.82386675
140EED_16625203_ChIP-ChIP_MESCs_Mouse0.82307407
141JARID2_20075857_ChIP-Seq_MESCs_Mouse0.81944826
142ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81926121
143TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81727277
144POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81727277
145* RING1B_27294783_Chip-Seq_NPCs_Mouse0.81295662
146* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.81241997
147SALL1_21062744_ChIP-ChIP_HESCs_Human0.80607418
148TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80337485
149ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80288564
150ATF3_27146783_Chip-Seq_COLON_Human0.80126195
151SUZ12_27294783_Chip-Seq_ESCs_Mouse0.79489362
152EGR1_19032775_ChIP-ChIP_M12_Human0.79290209
153ESR1_15608294_ChIP-ChIP_MCF-7_Human0.79079675
154SMAD4_21741376_ChIP-Seq_EPCs_Human0.79011815
155PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.78930720
156PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78533412
157SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.78377387
158SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77964736
159EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.77886844
160SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77816926
161CDX2_20551321_ChIP-Seq_CACO-2_Human0.77794412
162SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.77710305
163SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76237088
164* SMAD4_21741376_ChIP-Seq_HESCs_Human0.76150834
165EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.75539983
166EZH2_27294783_Chip-Seq_ESCs_Mouse0.74615752
167SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73315693
168KDM2B_26808549_Chip-Seq_JURKAT_Human0.72644543
169AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72292034
170HIF1A_21447827_ChIP-Seq_MCF-7_Human0.72250000
171PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.70978657
172CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70049419
173WT1_25993318_ChIP-Seq_PODOCYTE_Human0.69775915
174RUNX1_27514584_Chip-Seq_MCF-7_Human0.69176718
175SOX2_20726797_ChIP-Seq_SW620_Human0.68837700
176NFIB_24661679_ChIP-Seq_LUNG_Mouse0.68746675
177KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.67943793
178TP53_20018659_ChIP-ChIP_R1E_Mouse0.67473812
179KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.66905062
180BCAT_22108803_ChIP-Seq_LS180_Human0.66584569
181* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.66445496
182P300_27058665_Chip-Seq_ZR-75-30cells_Human0.66316138
183SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.65615301

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.45693431
2MP0002139_abnormal_hepatobiliary_system6.44142651
3MP0005085_abnormal_gallbladder_physiolo5.31926720
4MP0005365_abnormal_bile_salt5.03989507
5MP0008875_abnormal_xenobiotic_pharmacok4.58431797
6MP0003252_abnormal_bile_duct3.57966286
7MP0003880_abnormal_central_pattern3.35454851
8MP0005423_abnormal_somatic_nervous3.35137092
9MP0003011_delayed_dark_adaptation3.07586204
10MP0005499_abnormal_olfactory_system3.07449236
11MP0005394_taste/olfaction_phenotype3.07449236
12MP0010329_abnormal_lipoprotein_level3.01571786
13MP0009840_abnormal_foam_cell2.93530194
14MP0006292_abnormal_olfactory_placode2.88162613
15MP0003806_abnormal_nucleotide_metabolis2.83037449
16MP0008789_abnormal_olfactory_epithelium2.71984701
17MP0005332_abnormal_amino_acid2.60159286
18MP0003195_calcinosis2.41030126
19MP0006276_abnormal_autonomic_nervous2.35427121
20MP0000049_abnormal_middle_ear2.29602642
21MP0000778_abnormal_nervous_system2.24499015
22MP0003191_abnormal_cellular_cholesterol2.18361636
23MP0004019_abnormal_vitamin_homeostasis2.15865333
24MP0010030_abnormal_orbit_morphology2.12214976
25MP0001666_abnormal_nutrient_absorption2.10965737
26MP0005083_abnormal_biliary_tract2.03804417
27MP0001529_abnormal_vocalization1.98641505
28MP0002118_abnormal_lipid_homeostasis1.75906786
29MP0003122_maternal_imprinting1.75063682
30MP0000609_abnormal_liver_physiology1.73470720
31MP0002138_abnormal_hepatobiliary_system1.72840091
32MP0010368_abnormal_lymphatic_system1.71070350
33MP0002233_abnormal_nose_morphology1.69030310
34MP0002837_dystrophic_cardiac_calcinosis1.62729293
35MP0003705_abnormal_hypodermis_morpholog1.62224110
36MP0004133_heterotaxia1.61929954
37MP0004270_analgesia1.61748432
38MP0002751_abnormal_autonomic_nervous1.61087219
39MP0005319_abnormal_enzyme/_coenzyme1.60905817
40MP0008995_early_reproductive_senescence1.51707495
41MP0003329_amyloid_beta_deposits1.50534804
42MP0002102_abnormal_ear_morphology1.48749359
43MP0009643_abnormal_urine_homeostasis1.47287701
44MP0002254_reproductive_system_inflammat1.47271893
45MP0002184_abnormal_innervation1.44790995
46MP0003121_genomic_imprinting1.43217056
47MP0002234_abnormal_pharynx_morphology1.37424025
48MP0005551_abnormal_eye_electrophysiolog1.36674061
49MP0005410_abnormal_fertilization1.35931988
50MP0003937_abnormal_limbs/digits/tail_de1.32824639
51MP0001188_hyperpigmentation1.32047373
52MP0008877_abnormal_DNA_methylation1.31445880
53MP0002822_catalepsy1.31396935
54MP0003385_abnormal_body_wall1.29584189
55MP0000604_amyloidosis1.29192442
56MP0005584_abnormal_enzyme/coenzyme_acti1.28269277
57MP0002736_abnormal_nociception_after1.27856956
58MP0002638_abnormal_pupillary_reflex1.26736204
59MP0003755_abnormal_palate_morphology1.25148172
60MP0003938_abnormal_ear_development1.24743154
61MP0009053_abnormal_anal_canal1.24026815
62MP0003787_abnormal_imprinting1.23824446
63MP0001756_abnormal_urination1.20336065
64MP0001984_abnormal_olfaction1.19921237
65MP0001764_abnormal_homeostasis1.18939109
66MP0002160_abnormal_reproductive_system1.16698434
67MP0002272_abnormal_nervous_system1.15954877
68MP0005670_abnormal_white_adipose1.15710837
69MP0004036_abnormal_muscle_relaxation1.13642761
70MP0004084_abnormal_cardiac_muscle1.13000304
71MP0002557_abnormal_social/conspecific_i1.12402498
72MP0002734_abnormal_mechanical_nocicepti1.10374707
73MP0005451_abnormal_body_composition1.10137341
74MP0003635_abnormal_synaptic_transmissio1.09539322
75MP0002249_abnormal_larynx_morphology1.08655085
76MP0000955_abnormal_spinal_cord1.06923058
77MP0000762_abnormal_tongue_morphology1.04256590
78MP0000566_synostosis1.03765837
79MP0004859_abnormal_synaptic_plasticity1.03658643
80MP0003861_abnormal_nervous_system1.02859478
81MP0005636_abnormal_mineral_homeostasis1.01999234
82MP0005167_abnormal_blood-brain_barrier1.01867497
83MP0003868_abnormal_feces_composition1.00186621
84MP0002882_abnormal_neuron_morphology0.99428312
85MP0001286_abnormal_eye_development0.98170382
86MP0002572_abnormal_emotion/affect_behav0.97822088
87MP0001502_abnormal_circadian_rhythm0.97818378
88MP0002210_abnormal_sex_determination0.96561324
89MP0002752_abnormal_somatic_nervous0.96044956
90MP0003942_abnormal_urinary_system0.95629805
91MP0003718_maternal_effect0.95012713
92MP0004811_abnormal_neuron_physiology0.94905338
93MP0001968_abnormal_touch/_nociception0.94663843
94MP0009384_cardiac_valve_regurgitation0.93999777
95MP0000631_abnormal_neuroendocrine_gland0.93613131
96MP0003935_abnormal_craniofacial_develop0.93418551
97MP0009046_muscle_twitch0.92005485
98MP0005647_abnormal_sex_gland0.91759522
99MP0000579_abnormal_nail_morphology0.90797339
100MP0000230_abnormal_systemic_arterial0.90792498
101MP0001929_abnormal_gametogenesis0.89756671
102MP0002282_abnormal_trachea_morphology0.89406021
103MP0004142_abnormal_muscle_tone0.89210998
104MP0000678_abnormal_parathyroid_gland0.88883132
105MP0004272_abnormal_basement_membrane0.88706211
106MP0005623_abnormal_meninges_morphology0.88257023
107MP0003698_abnormal_male_reproductive0.87115261
108MP0003315_abnormal_perineum_morphology0.86265817
109MP0009764_decreased_sensitivity_to0.86176924
110MP0004043_abnormal_pH_regulation0.85661269
111MP0000427_abnormal_hair_cycle0.85452198
112MP0001765_abnormal_ion_homeostasis0.85389240
113MP0002090_abnormal_vision0.85251391
114MP0001879_abnormal_lymphatic_vessel0.84984722
115MP0004885_abnormal_endolymph0.84858204
116MP0002909_abnormal_adrenal_gland0.84078673
117MP0000026_abnormal_inner_ear0.83030800
118MP0005391_vision/eye_phenotype0.82835047
119MP0005187_abnormal_penis_morphology0.82212384
120MP0001986_abnormal_taste_sensitivity0.82109878
121MP0000647_abnormal_sebaceous_gland0.81472350
122MP0000462_abnormal_digestive_system0.81021249
123MP0002063_abnormal_learning/memory/cond0.80724333
124MP0002152_abnormal_brain_morphology0.80312480
125MP0009697_abnormal_copulation0.79699030
126MP0000598_abnormal_liver_morphology0.78743308
127MP0001299_abnormal_eye_distance/0.77663992
128MP0002136_abnormal_kidney_physiology0.77443494
129MP0008961_abnormal_basal_metabolism0.77393811
130MP0000516_abnormal_urinary_system0.76386322
131MP0005367_renal/urinary_system_phenotyp0.76386322
132MP0003567_abnormal_fetal_cardiomyocyte0.76114709
133MP0003890_abnormal_embryonic-extraembry0.75369213
134MP0002796_impaired_skin_barrier0.74686009
135MP0005389_reproductive_system_phenotype0.73697162
136MP0000467_abnormal_esophagus_morphology0.73181150
137MP0009250_abnormal_appendicular_skeleto0.73079340
138MP0000767_abnormal_smooth_muscle0.72806742
139MP0009642_abnormal_blood_homeostasis0.72668734
140MP0005197_abnormal_uvea_morphology0.72332800
141MP0001293_anophthalmia0.72076360
142MP0000639_abnormal_adrenal_gland0.72066449
143MP0009745_abnormal_behavioral_response0.71923566
144MP0002697_abnormal_eye_size0.71520694
145MP0001340_abnormal_eyelid_morphology0.71387907
146MP0002078_abnormal_glucose_homeostasis0.70348262
147MP0005195_abnormal_posterior_eye0.70247257
148MP0006138_congestive_heart_failure0.69712913
149MP0006072_abnormal_retinal_apoptosis0.69279765
150MP0003221_abnormal_cardiomyocyte_apopto0.68065429
151MP0009763_increased_sensitivity_to0.68063285
152MP0003566_abnormal_cell_adhesion0.66774277
153MP0002269_muscular_atrophy0.66595917
154MP0010234_abnormal_vibrissa_follicle0.66250438
155MP0005330_cardiomyopathy0.65953370
156MP0005084_abnormal_gallbladder_morpholo0.64947141
157MP0005166_decreased_susceptibility_to0.63251892
158MP0000751_myopathy0.62981928
159MP0005666_abnormal_adipose_tissue0.61207490
160MP0002332_abnormal_exercise_endurance0.61030396
161MP0008874_decreased_physiological_sensi0.60885854
162MP0002653_abnormal_ependyma_morphology0.60570779
163MP0005375_adipose_tissue_phenotype0.59662570
164MP0005376_homeostasis/metabolism_phenot0.58819288
165MP0005165_increased_susceptibility_to0.57992719
166MP0004130_abnormal_muscle_cell0.57339800
167MP0003283_abnormal_digestive_organ0.57033922
168MP0000003_abnormal_adipose_tissue0.56522042
169MP0003119_abnormal_digestive_system0.56373521
170MP0003453_abnormal_keratinocyte_physiol0.56157132
171MP0000013_abnormal_adipose_tissue0.55926453
172MP0005253_abnormal_eye_physiology0.55661124
173MP0003075_altered_response_to0.52784916
174MP0003724_increased_susceptibility_to0.52658408
175MP0008873_increased_physiological_sensi0.51311194
176MP0002135_abnormal_kidney_morphology0.50856105
177MP0001661_extended_life_span0.49994882
178MP0002971_abnormal_brown_adipose0.49374584
179MP0002295_abnormal_pulmonary_circulatio0.48748930
180MP0004185_abnormal_adipocyte_glucose0.48687320
181MP0000534_abnormal_ureter_morphology0.48648497
182MP0001270_distended_abdomen0.46775982
183MP0008469_abnormal_protein_level0.46087612
184MP0004085_abnormal_heartbeat0.45898932
185MP0002127_abnormal_cardiovascular_syste0.45835080
186MP0003638_abnormal_response/metabolism_0.45303034
187MP0000749_muscle_degeneration0.45196822
188MP0009765_abnormal_xenobiotic_induced0.45131251

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.38252926
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.05507300
3Intrahepatic cholestasis (HP:0001406)5.62625629
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.52066380
5Xanthomatosis (HP:0000991)5.38759310
6Complement deficiency (HP:0004431)4.88372757
7Prolonged partial thromboplastin time (HP:0003645)4.64439576
8Hypobetalipoproteinemia (HP:0003563)4.62658401
9Hyperlipoproteinemia (HP:0010980)4.34112068
10Abnormality of glutamine family amino acid metabolism (HP:0010902)3.87017597
11Hypolipoproteinemia (HP:0010981)3.84536049
12Hypoalphalipoproteinemia (HP:0003233)3.76789201
13Abnormality of the common coagulation pathway (HP:0010990)3.72540001
14Joint hemorrhage (HP:0005261)3.63689624
15Hyperammonemia (HP:0001987)3.59645052
16Ketosis (HP:0001946)3.56857144
17Abnormality of complement system (HP:0005339)3.56596253
18Abnormality of sulfur amino acid metabolism (HP:0004339)3.45675961
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.38551725
20Abnormality of methionine metabolism (HP:0010901)3.19946433
21Abnormality of the intrinsic pathway (HP:0010989)3.17074689
22Hypoglycemic coma (HP:0001325)3.14216775
23Gout (HP:0001997)3.13886129
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.10419991
25Epidermoid cyst (HP:0200040)3.09609343
26Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.06470749
27Hyperglycinuria (HP:0003108)3.03702931
28Cortical dysplasia (HP:0002539)3.00055089
29Ketoacidosis (HP:0001993)2.99192922
30Fat malabsorption (HP:0002630)2.96409742
31Abnormal pancreas size (HP:0012094)2.93841736
32Hyperglycinemia (HP:0002154)2.92138197
33Right ventricular cardiomyopathy (HP:0011663)2.91529410
34Hypercholesterolemia (HP:0003124)2.89580867
35Malnutrition (HP:0004395)2.82576185
36Abnormality of fatty-acid metabolism (HP:0004359)2.81758226
37Congenital malformation of the right heart (HP:0011723)2.81607235
38Double outlet right ventricle (HP:0001719)2.81607235
39Abnormality of glycine metabolism (HP:0010895)2.78530724
40Abnormality of serine family amino acid metabolism (HP:0010894)2.78530724
41Systemic lupus erythematosus (HP:0002725)2.78258420
42Pigmentary retinal degeneration (HP:0001146)2.74841256
43Abnormality of the labia minora (HP:0012880)2.73332217
44Periauricular skin pits (HP:0100277)2.70723606
45Preauricular pit (HP:0004467)2.70723606
46Limb dystonia (HP:0002451)2.70117209
47Delayed CNS myelination (HP:0002188)2.68438136
48Conjugated hyperbilirubinemia (HP:0002908)2.68036404
49Congenital stationary night blindness (HP:0007642)2.59436209
50Sensorimotor neuropathy (HP:0007141)2.59151911
51Mesangial abnormality (HP:0001966)2.57011667
52Shoulder girdle muscle weakness (HP:0003547)2.55752317
53Abnormality of purine metabolism (HP:0004352)2.54225635
54Polycythemia (HP:0001901)2.54089683
55Hepatocellular carcinoma (HP:0001402)2.50849837
56Labial hypoplasia (HP:0000066)2.49699169
57Focal segmental glomerulosclerosis (HP:0000097)2.47841548
58Myocardial infarction (HP:0001658)2.45144116
59Late onset (HP:0003584)2.44191089
60Hepatoblastoma (HP:0002884)2.42818277
61Hyperbilirubinemia (HP:0002904)2.42659236
62Chorioretinal atrophy (HP:0000533)2.41443380
63Gait imbalance (HP:0002141)2.40457044
64Abnormal gallbladder physiology (HP:0012438)2.39516134
65Cholecystitis (HP:0001082)2.39516134
66Adrenal hypoplasia (HP:0000835)2.38955263
67Polyphagia (HP:0002591)2.38817336
68Renal dysplasia (HP:0000110)2.38448965
69Abnormality of nucleobase metabolism (HP:0010932)2.38409547
70Glomerulonephritis (HP:0000099)2.37162963
71Hypoplastic female external genitalia (HP:0012815)2.35922154
72Hypoglycemic seizures (HP:0002173)2.35822050
73Abnormality of proline metabolism (HP:0010907)2.33814773
74Hydroxyprolinuria (HP:0003080)2.33814773
75Vascular calcification (HP:0004934)2.31872080
76Nephritis (HP:0000123)2.31668754
77Neonatal onset (HP:0003623)2.28274473
78Glomerulosclerosis (HP:0000096)2.26508784
79Brushfield spots (HP:0001088)2.26265179
80Alkalosis (HP:0001948)2.25970788
81Medial flaring of the eyebrow (HP:0010747)2.25523367
82Abnormality of the lower motor neuron (HP:0002366)2.24695402
83Congenital primary aphakia (HP:0007707)2.24063851
84Nephrogenic diabetes insipidus (HP:0009806)2.23977742
85Mitral stenosis (HP:0001718)2.22684178
86Esophageal varix (HP:0002040)2.22315410
87Split foot (HP:0001839)2.20969853
88Abnormality of the aortic arch (HP:0012303)2.20683948
89Cholelithiasis (HP:0001081)2.18895950
90Hyperactive renin-angiotensin system (HP:0000841)2.17936619
91Short tibia (HP:0005736)2.17893728
92Abdominal situs inversus (HP:0003363)2.17586143
93Abnormality of abdominal situs (HP:0011620)2.17586143
94Poor suck (HP:0002033)2.17271725
95Stroke (HP:0001297)2.17016780
96Abnormality of the labia (HP:0000058)2.16679949
97Abnormal gallbladder morphology (HP:0012437)2.16407463
98Spontaneous abortion (HP:0005268)2.11800139
99Skin nodule (HP:0200036)2.09998248
100Pachygyria (HP:0001302)2.08659783
101Cardiovascular calcification (HP:0011915)2.08584029
102Abnormality of pyrimidine metabolism (HP:0004353)2.06777372
103Oligodactyly (hands) (HP:0001180)2.06659200
104Spastic diplegia (HP:0001264)2.05909989
105Retinal atrophy (HP:0001105)2.04949459
106Metabolic acidosis (HP:0001942)2.02245024
107Hypoplastic pelvis (HP:0008839)2.01738398
108Pancreatic fibrosis (HP:0100732)2.01493579
109Amyloidosis (HP:0011034)1.99846366
110Down-sloping shoulders (HP:0200021)1.98442076
111Hypoplasia of the brainstem (HP:0002365)1.98420065
112Aplasia/Hypoplasia of the brainstem (HP:0007362)1.98420065
113Lissencephaly (HP:0001339)1.97848416
114Turricephaly (HP:0000262)1.97822323
115Genital tract atresia (HP:0001827)1.96699979
116Preaxial hand polydactyly (HP:0001177)1.96232725
117Aplasia/Hypoplasia of the tibia (HP:0005772)1.96044133
118Cerebral palsy (HP:0100021)1.95514227
119Tubulointerstitial nephritis (HP:0001970)1.95001151
120Myokymia (HP:0002411)1.94814126
121Irritability (HP:0000737)1.93496516
122Sclerocornea (HP:0000647)1.93065609
123Hyperinsulinemic hypoglycemia (HP:0000825)1.92780808
124Retinal dysplasia (HP:0007973)1.91664982
125Hyporeflexia of lower limbs (HP:0002600)1.91603065
126Hemorrhage of the eye (HP:0011885)1.90882654
127Abnormality of serum amino acid levels (HP:0003112)1.90213604
128Abnormality of the Achilles tendon (HP:0005109)1.89986878
129True hermaphroditism (HP:0010459)1.89812011
130Fragile nails (HP:0001808)1.88568017
131Steatorrhea (HP:0002570)1.87760494
132Vaginal atresia (HP:0000148)1.87318749
133Upper limb amyotrophy (HP:0009129)1.85526969
134Distal upper limb amyotrophy (HP:0007149)1.85526969
135Hyperglycemia (HP:0003074)1.84823756
136Amyotrophic lateral sclerosis (HP:0007354)1.83604207
137Abnormality of the pulmonary veins (HP:0011718)1.82880550
138Skin pits (HP:0100276)1.82258286
139Aplasia/Hypoplasia of the tongue (HP:0010295)1.81935757
140Increased purine levels (HP:0004368)1.80861727
141Hyperuricemia (HP:0002149)1.80861727
142Abnormality of the gallbladder (HP:0005264)1.80367761
143Chronic hepatic failure (HP:0100626)1.80236333
144Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.80112103
145Lethargy (HP:0001254)1.79035458
146Muscle fiber splitting (HP:0003555)1.77737437
147Vomiting (HP:0002013)1.77707276
148Abnormal mitochondria in muscle tissue (HP:0008316)1.77062925
149Anterior segment dysgenesis (HP:0007700)1.76642190
150Acute necrotizing encephalopathy (HP:0006965)1.76504478
151Abnormality of endocrine pancreas physiology (HP:0012093)1.76312564
152Abnormality of the pancreatic islet cells (HP:0006476)1.76312564
153Amblyopia (HP:0000646)1.76113480
154Stenosis of the external auditory canal (HP:0000402)1.75141476
155Osteomalacia (HP:0002749)1.75131621
156Concave nail (HP:0001598)1.74957048
157Abnormality of midbrain morphology (HP:0002418)1.72943422
158Molar tooth sign on MRI (HP:0002419)1.72943422
159Wrist flexion contracture (HP:0001239)1.72824526
160Spastic tetraplegia (HP:0002510)1.72336116
161Rib fusion (HP:0000902)1.72090286
162Median cleft lip (HP:0000161)1.70483703
163Upper limb muscle weakness (HP:0003484)1.69403811
164Oligodactyly (HP:0012165)1.69310853
165Occipital encephalocele (HP:0002085)1.68245764
166Pancreatic cysts (HP:0001737)1.68176171
167Drooling (HP:0002307)1.67087366
168Abnormality of the hip-girdle musculature (HP:0001445)1.66211876
169Abnormality of the musculature of the pelvis (HP:0001469)1.66211876
170Thyroid-stimulating hormone excess (HP:0002925)1.65286337
171Renal hypoplasia (HP:0000089)1.65053650
172Broad alveolar ridges (HP:0000187)1.64655176
173Renal Fanconi syndrome (HP:0001994)1.63918947
174Abnormality of the corticospinal tract (HP:0002492)1.63066800
175Facial cleft (HP:0002006)1.62005329
176Increased CSF lactate (HP:0002490)1.61795094
177Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.60939938
178Abnormality of alanine metabolism (HP:0010916)1.60939938
179Hyperalaninemia (HP:0003348)1.60939938
180Hip dysplasia (HP:0001385)1.59795455
181Micropenis (HP:0000054)1.59512340
182Postaxial hand polydactyly (HP:0001162)1.59492323
183Specific learning disability (HP:0001328)1.59460255
184Transposition of the great arteries (HP:0001669)1.58370960
185Abnormal connection of the cardiac segments (HP:0011545)1.58370960
186Abnormal ventriculo-arterial connection (HP:0011563)1.58370960
187Alopecia of scalp (HP:0002293)1.57509625
188Gonadotropin excess (HP:0000837)1.57092124
189Premature ovarian failure (HP:0008209)1.56915598
190High anterior hairline (HP:0009890)1.56285076
191Intestinal atresia (HP:0011100)1.53786925
192Long foot (HP:0001833)1.53768555
193Atrophy/Degeneration involving motor neurons (HP:0007373)1.52676261
194Anencephaly (HP:0002323)1.52476858
195Hemivertebrae (HP:0002937)1.52402585
196Aplasia/Hypoplasia of the lens (HP:0008063)1.52023657
197Male infertility (HP:0003251)1.51962305
198Anophthalmia (HP:0000528)1.51516399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.95421423
2TRIM283.89598313
3FGFR43.65289309
4BCKDK3.38471309
5MARK13.32483470
6LATS23.18352623
7KDR2.92302451
8MAP4K22.81758688
9CASK2.67889519
10MYLK2.65481101
11STK162.47508375
12TIE12.45279886
13BCR2.32386320
14TRIB32.12537719
15SRPK12.11505562
16BMPR1B2.04903903
17MAP3K21.96655401
18DYRK21.85204266
19ERBB41.83548404
20EPHA41.83188957
21MAPK131.79088395
22DAPK21.77574862
23KSR21.77179580
24TGFBR21.76905241
25DYRK31.72979432
26MAP2K41.69060170
27TTN1.59583853
28INSRR1.57386747
29FER1.49766650
30GRK11.49127878
31SIK11.48801381
32CDK191.45990745
33PBK1.44442123
34PDK21.43910454
35MINK11.43724539
36LATS11.37066922
37WNK41.34986892
38FGFR21.34579394
39TESK21.27532999
40CSNK1G21.26948861
41SGK4941.24866822
42SGK2231.24866822
43MAP3K71.23021376
44CSNK1G11.21787510
45TAOK11.21296779
46AKT31.19673118
47MUSK1.18995388
48CSNK1G31.18486862
49PDGFRA1.16738956
50PLK41.13720364
51MAP2K21.13453894
52MST1R1.12884665
53TAOK31.10960582
54ERBB31.07800568
55EPHA21.07607875
56PIM21.06310038
57TGFBR11.04809737
58MAPK151.03587791
59AURKA1.03507906
60PTK61.01039089
61SIK30.99315303
62PRKD30.98940265
63CSNK1A1L0.98163405
64EIF2AK30.97539476
65RIPK10.96389626
66PRKCG0.95683954
67MAP3K120.92482807
68MAP3K100.90962680
69MAP3K10.90834231
70SGK30.88932925
71EPHB20.88702862
72MARK20.88508179
73PRKD10.88215401
74DAPK30.88204224
75CAMK2G0.87949614
76FGFR10.87261910
77TESK10.86917633
78PIK3CG0.86447239
79MAP3K60.85991090
80TSSK60.85751471
81NTRK20.83978437
82MAP2K10.83973896
83MAPK120.83727289
84ROCK10.83699285
85MAP3K30.83536784
86PRKCE0.83459047
87KSR10.81676511
88MAP3K90.80961922
89ACVR1B0.79508048
90GSK3A0.79490988
91DMPK0.78357032
92PLK20.78326893
93PAK30.78079155
94MAP3K40.77065941
95NTRK30.76884749
96PINK10.75859020
97BMX0.74538583
98MAPK70.74238394
99STK380.73648816
100MET0.73303094
101PTK20.72556806
102OXSR10.70829623
103PRKCH0.70638848
104PRKAA20.69083131
105PDPK10.67265137
106PNCK0.66598798
107PKN10.65920202
108SGK20.65425997
109EPHA30.63696372
110JAK20.61785735
111TYRO30.59266338
112CDK50.58477546
113STK38L0.57717746
114TNIK0.57630095
115DYRK1A0.56977691
116PRKG20.56175645
117RAF10.56063000
118CAMK2A0.55481809
119RPS6KA40.55064662
120ZAK0.54278178
121PRKCZ0.54162576
122STK390.53538961
123PTK2B0.52897086
124PLK10.52873372
125DYRK1B0.52683608
126JAK10.52571654
127SIK20.52367324
128MAP3K50.52209109
129EPHB10.52182677
130ADRBK10.51568169
131LIMK10.51398642
132MAP3K110.51023126
133MAPKAPK30.50475350
134MAP2K70.50319497
135RPS6KA20.49953594
136LMTK20.49878320
137PRKD20.49779901
138PAK60.49163769
139ABL20.48889048
140CAMK2B0.48410179
141BRSK10.48394076
142VRK10.47146836
143PKN20.46923467
144PAK40.46566046
145CAMK40.46541379
146NUAK10.46524801
147MOS0.45880864
148ARAF0.45524468
149BRAF0.44989123
150MTOR0.44437250
151CSNK1E0.43415543
152CSNK1A10.42709662
153WNK30.42360887
154MAP2K60.41824899
155ITK0.41695560
156PRKACA0.40636212
157CDK140.39154677
158RPS6KA50.39066251
159UHMK10.35270478
160PAK10.33265251
161CDK11A0.32643461
162ICK0.32222870
163ILK0.32133300
164CDK180.31801176

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.61385389
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.21813972
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.18892975
4Arginine biosynthesis_Homo sapiens_hsa002203.60940060
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.85918745
6Steroid biosynthesis_Homo sapiens_hsa001002.81306363
7Complement and coagulation cascades_Homo sapiens_hsa046102.71174499
8Tryptophan metabolism_Homo sapiens_hsa003802.44234818
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.37128675
10Fatty acid degradation_Homo sapiens_hsa000712.18901431
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.09489223
12Oxidative phosphorylation_Homo sapiens_hsa001902.06654968
13Protein export_Homo sapiens_hsa030602.01901733
14Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.00282434
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.99509015
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.95031599
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90300908
18Parkinsons disease_Homo sapiens_hsa050121.87723016
19Synaptic vesicle cycle_Homo sapiens_hsa047211.86234458
20Nicotine addiction_Homo sapiens_hsa050331.80588930
21Butanoate metabolism_Homo sapiens_hsa006501.76762279
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.76489627
23PPAR signaling pathway_Homo sapiens_hsa033201.74469668
24Bile secretion_Homo sapiens_hsa049761.74355521
25Peroxisome_Homo sapiens_hsa041461.73801202
26Retinol metabolism_Homo sapiens_hsa008301.72820055
27Histidine metabolism_Homo sapiens_hsa003401.64103617
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62847218
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60578343
30Basal transcription factors_Homo sapiens_hsa030221.59741194
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.58306367
32Caffeine metabolism_Homo sapiens_hsa002321.54269923
33Huntingtons disease_Homo sapiens_hsa050161.53337395
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.52985054
35Chemical carcinogenesis_Homo sapiens_hsa052041.51517857
36Propanoate metabolism_Homo sapiens_hsa006401.45442031
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44818597
38Phenylalanine metabolism_Homo sapiens_hsa003601.44743232
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44113148
40beta-Alanine metabolism_Homo sapiens_hsa004101.42005776
41Axon guidance_Homo sapiens_hsa043601.40147858
42Phototransduction_Homo sapiens_hsa047441.40069536
43Fatty acid metabolism_Homo sapiens_hsa012121.39981176
44Selenocompound metabolism_Homo sapiens_hsa004501.39865788
45Staphylococcus aureus infection_Homo sapiens_hsa051501.39813806
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.39215352
47Biosynthesis of amino acids_Homo sapiens_hsa012301.28792185
48Collecting duct acid secretion_Homo sapiens_hsa049661.27530596
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26795287
50Cardiac muscle contraction_Homo sapiens_hsa042601.26496652
51Pyruvate metabolism_Homo sapiens_hsa006201.24746831
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24223818
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.24161739
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23225894
55Drug metabolism - other enzymes_Homo sapiens_hsa009831.22232539
56Hippo signaling pathway_Homo sapiens_hsa043901.21277046
57ABC transporters_Homo sapiens_hsa020101.20990699
58Tyrosine metabolism_Homo sapiens_hsa003501.19529593
59Cysteine and methionine metabolism_Homo sapiens_hsa002701.14102512
60Vibrio cholerae infection_Homo sapiens_hsa051101.13594625
61TGF-beta signaling pathway_Homo sapiens_hsa043501.12679872
62Maturity onset diabetes of the young_Homo sapiens_hsa049501.10405498
63Basal cell carcinoma_Homo sapiens_hsa052171.10325143
64Hedgehog signaling pathway_Homo sapiens_hsa043401.09555107
65RNA polymerase_Homo sapiens_hsa030201.08871198
66Alzheimers disease_Homo sapiens_hsa050101.06762868
67Carbon metabolism_Homo sapiens_hsa012001.04342756
68Dopaminergic synapse_Homo sapiens_hsa047281.04301286
69Fat digestion and absorption_Homo sapiens_hsa049751.03857345
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03011156
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98434509
72Starch and sucrose metabolism_Homo sapiens_hsa005000.97082546
73RNA degradation_Homo sapiens_hsa030180.95726804
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95616494
75Arginine and proline metabolism_Homo sapiens_hsa003300.94438882
76Folate biosynthesis_Homo sapiens_hsa007900.93960195
77RNA transport_Homo sapiens_hsa030130.93628983
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89493307
79Sulfur metabolism_Homo sapiens_hsa009200.87011469
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77633968
81Fatty acid elongation_Homo sapiens_hsa000620.77620902
82Insulin secretion_Homo sapiens_hsa049110.76707814
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76366549
84mRNA surveillance pathway_Homo sapiens_hsa030150.75300191
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75276862
86Olfactory transduction_Homo sapiens_hsa047400.75095406
87Oocyte meiosis_Homo sapiens_hsa041140.73221813
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72967757
89Ribosome_Homo sapiens_hsa030100.72162623
90Glutamatergic synapse_Homo sapiens_hsa047240.71789864
91Prion diseases_Homo sapiens_hsa050200.71453445
92Morphine addiction_Homo sapiens_hsa050320.69824279
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69352138
94Vitamin digestion and absorption_Homo sapiens_hsa049770.67240778
95Lysine degradation_Homo sapiens_hsa003100.66729074
96Proteasome_Homo sapiens_hsa030500.66383376
97Wnt signaling pathway_Homo sapiens_hsa043100.64344958
98Circadian entrainment_Homo sapiens_hsa047130.61627835
99Taste transduction_Homo sapiens_hsa047420.61381940
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60707299
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60378953
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59838721
103Amphetamine addiction_Homo sapiens_hsa050310.59388048
104Gap junction_Homo sapiens_hsa045400.58384966
105Serotonergic synapse_Homo sapiens_hsa047260.57199674
106Spliceosome_Homo sapiens_hsa030400.56678735
107Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55997220
108Vitamin B6 metabolism_Homo sapiens_hsa007500.53876221
109Alcoholism_Homo sapiens_hsa050340.53053058
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52292752
111Glycerolipid metabolism_Homo sapiens_hsa005610.52213772
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50679976
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.49170939
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47206047
115Sulfur relay system_Homo sapiens_hsa041220.43841781
116Insulin resistance_Homo sapiens_hsa049310.43060175
117Pentose phosphate pathway_Homo sapiens_hsa000300.37051558
118Glucagon signaling pathway_Homo sapiens_hsa049220.33254277
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31994404
120Glutathione metabolism_Homo sapiens_hsa004800.31014205
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30677491
122Thyroid hormone synthesis_Homo sapiens_hsa049180.26133006
123Circadian rhythm_Homo sapiens_hsa047100.23273187
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.22328041
125Metabolic pathways_Homo sapiens_hsa011000.22175108
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18138876
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.17761568
128Amoebiasis_Homo sapiens_hsa051460.16446443
129ECM-receptor interaction_Homo sapiens_hsa045120.16191727
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.15198960
131Dilated cardiomyopathy_Homo sapiens_hsa054140.14698412
132AMPK signaling pathway_Homo sapiens_hsa041520.13113489
133GABAergic synapse_Homo sapiens_hsa047270.12438387
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.11968531
135Fatty acid biosynthesis_Homo sapiens_hsa000610.11892277
136Bladder cancer_Homo sapiens_hsa052190.11167870
137Galactose metabolism_Homo sapiens_hsa000520.10942586
138Linoleic acid metabolism_Homo sapiens_hsa005910.10572256
139Adherens junction_Homo sapiens_hsa045200.10392724
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.09775992
141Glycosaminoglycan degradation_Homo sapiens_hsa005310.08742758
142Regulation of autophagy_Homo sapiens_hsa041400.08060591
143Fructose and mannose metabolism_Homo sapiens_hsa000510.06248927
144Focal adhesion_Homo sapiens_hsa045100.04940890
145Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.04770896
146Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.04686696
147Insulin signaling pathway_Homo sapiens_hsa049100.04173104
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.03689439
149Ovarian steroidogenesis_Homo sapiens_hsa049130.03124066
150Cocaine addiction_Homo sapiens_hsa050300.02270324
151Rap1 signaling pathway_Homo sapiens_hsa040150.01614358

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