ARL5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. With its distinctive nuclear/nucleolar localization and interaction with HP1alpha, the protein is developmentally regulated and may play a role(s) in nuclear dynamics and/or signaling cascades during embryonic development. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.91847069
2nuclear pore organization (GO:0006999)6.85927922
3pore complex assembly (GO:0046931)5.43334697
4mitotic sister chromatid cohesion (GO:0007064)4.90521523
5DNA unwinding involved in DNA replication (GO:0006268)4.81981061
6DNA topological change (GO:0006265)4.46023876
7negative regulation of DNA repair (GO:0045738)4.28425660
8regulation of RNA export from nucleus (GO:0046831)4.20376692
9growth hormone receptor signaling pathway (GO:0060396)4.10690933
10negative regulation of B cell proliferation (GO:0030889)4.02728781
11formation of translation preinitiation complex (GO:0001731)3.99489057
12regulation of cytokine secretion involved in immune response (GO:0002739)3.94567852
13V(D)J recombination (GO:0033151)3.90212598
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.82721549
15L-phenylalanine catabolic process (GO:0006559)3.82721549
16glyoxylate metabolic process (GO:0046487)3.79757498
17sister chromatid segregation (GO:0000819)3.79342815
18mitotic G2/M transition checkpoint (GO:0044818)3.76404267
19regulation of centriole replication (GO:0046599)3.75892574
20mitotic chromosome condensation (GO:0007076)3.70501307
21ribosome assembly (GO:0042255)3.67868426
22CENP-A containing nucleosome assembly (GO:0034080)3.67560503
23regulation of sister chromatid cohesion (GO:0007063)3.67336113
24mitotic G2 DNA damage checkpoint (GO:0007095)3.67330383
25protein localization to chromosome, centromeric region (GO:0071459)3.66769798
26aromatic amino acid family catabolic process (GO:0009074)3.65638349
27negative regulation of fibrinolysis (GO:0051918)3.64319899
28chromatin remodeling at centromere (GO:0031055)3.61660512
29regulation of histone H3-K9 methylation (GO:0051570)3.56955998
30cellular glucuronidation (GO:0052695)3.50744332
31embryonic process involved in female pregnancy (GO:0060136)3.46662368
32regulation of chronic inflammatory response (GO:0002676)3.46450188
33urea metabolic process (GO:0019627)3.45657847
34urea cycle (GO:0000050)3.45657847
35protein carboxylation (GO:0018214)3.44645127
36peptidyl-glutamic acid carboxylation (GO:0017187)3.44645127
37indole-containing compound catabolic process (GO:0042436)3.43982378
38indolalkylamine catabolic process (GO:0046218)3.43982378
39tryptophan catabolic process (GO:0006569)3.43982378
40DNA duplex unwinding (GO:0032508)3.43032200
41cellular response to growth hormone stimulus (GO:0071378)3.42948662
42mitotic spindle checkpoint (GO:0071174)3.41534958
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.38379189
44L-phenylalanine metabolic process (GO:0006558)3.38379189
45tryptophan metabolic process (GO:0006568)3.37680834
46mitotic nuclear envelope disassembly (GO:0007077)3.37030508
47negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.36353822
48negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.36353822
49negative regulation of mitotic sister chromatid segregation (GO:0033048)3.36353822
50negative regulation of mitotic sister chromatid separation (GO:2000816)3.36353822
51negative regulation of sister chromatid segregation (GO:0033046)3.36353822
52regulation of nucleobase-containing compound transport (GO:0032239)3.36325525
53mitotic metaphase plate congression (GO:0007080)3.35816101
54protein localization to kinetochore (GO:0034501)3.35721329
55non-recombinational repair (GO:0000726)3.34064814
56double-strand break repair via nonhomologous end joining (GO:0006303)3.34064814
57regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.33614606
58regulation of mitotic metaphase/anaphase transition (GO:0030071)3.33614606
59DNA geometric change (GO:0032392)3.33561452
60negative regulation of chromosome segregation (GO:0051985)3.32176399
61regulation of fibrinolysis (GO:0051917)3.29312560
62negative regulation of fibroblast apoptotic process (GO:2000270)3.29090492
63bile acid biosynthetic process (GO:0006699)3.28204383
64mitotic spindle assembly checkpoint (GO:0007094)3.25775827
65complement activation, alternative pathway (GO:0006957)3.24661582
66regulation of sister chromatid segregation (GO:0033045)3.23762620
67regulation of mitotic sister chromatid separation (GO:0010965)3.23762620
68regulation of mitotic sister chromatid segregation (GO:0033047)3.23762620
69spindle checkpoint (GO:0031577)3.23600808
70triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.23022203
71regulation of translational fidelity (GO:0006450)3.22273028
72nuclear envelope disassembly (GO:0051081)3.21640495
73membrane disassembly (GO:0030397)3.21640495
74uronic acid metabolic process (GO:0006063)3.20866748
75glucuronate metabolic process (GO:0019585)3.20866748
76spindle assembly checkpoint (GO:0071173)3.19279254
77kinetochore organization (GO:0051383)3.18140943
78kynurenine metabolic process (GO:0070189)3.17420515
79pre-miRNA processing (GO:0031054)3.16651336
80regulation of chromosome segregation (GO:0051983)3.15486021
81mitotic sister chromatid segregation (GO:0000070)3.11531015
82monoubiquitinated protein deubiquitination (GO:0035520)3.09385780
83positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.09265427
84regulation of centrosome cycle (GO:0046605)3.07905290
85high-density lipoprotein particle remodeling (GO:0034375)3.07415270
86IMP metabolic process (GO:0046040)3.07332931
87phospholipid efflux (GO:0033700)3.05742523
88nitrogen cycle metabolic process (GO:0071941)3.04215670
89regulation of centrosome duplication (GO:0010824)3.03147054
90positive regulation of fatty acid beta-oxidation (GO:0032000)3.03096324
91keratinization (GO:0031424)3.02698834
92metaphase plate congression (GO:0051310)3.02545395
93regulation of protein activation cascade (GO:2000257)3.02445590
94histone exchange (GO:0043486)3.01946286
95phospholipid homeostasis (GO:0055091)3.01021469
96DNA replication-independent nucleosome assembly (GO:0006336)3.00689061
97DNA replication-independent nucleosome organization (GO:0034724)3.00689061
98regulation of cholesterol esterification (GO:0010872)3.00634118
99midgut development (GO:0007494)2.99388434
100cell adhesion mediated by integrin (GO:0033627)2.97303705
101dicarboxylic acid biosynthetic process (GO:0043650)2.96170543
102somatic cell DNA recombination (GO:0016444)2.95371285
103somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.95371285
104DNA replication initiation (GO:0006270)2.94467908
105bundle of His cell to Purkinje myocyte communication (GO:0086069)2.93990082
106nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.90042392
107negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.88580921
108alpha-linolenic acid metabolic process (GO:0036109)2.88442103
109cytoplasmic mRNA processing body assembly (GO:0033962)2.87865903
110DNA conformation change (GO:0071103)2.87676275
111establishment of integrated proviral latency (GO:0075713)2.87436983
112regulation of interferon-alpha production (GO:0032647)2.82662019
113response to inactivity (GO:0014854)2.81608375
114cellular protein complex localization (GO:0034629)2.81387314
115positive regulation of natural killer cell differentiation (GO:0032825)2.81038723
116regulation of complement activation (GO:0030449)2.80804037
117histone-serine phosphorylation (GO:0035404)2.80492066
118positive regulation of cell cycle checkpoint (GO:1901978)2.80457139
119IMP biosynthetic process (GO:0006188)2.79704353
120mitotic DNA integrity checkpoint (GO:0044774)2.79622736
121establishment of chromosome localization (GO:0051303)2.79481455
122DNA replication checkpoint (GO:0000076)2.79295761
123COPII vesicle coating (GO:0048208)2.79273758
124regulation of membrane protein ectodomain proteolysis (GO:0051043)2.78367320
125positive regulation of chromosome segregation (GO:0051984)2.78236398
126regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.78061153
127interkinetic nuclear migration (GO:0022027)2.75489324
128regulation of transforming growth factor beta2 production (GO:0032909)2.73652435
129reverse cholesterol transport (GO:0043691)2.70135199
130response to growth hormone (GO:0060416)2.69488196
131homocysteine metabolic process (GO:0050667)2.69334871
132ATP-dependent chromatin remodeling (GO:0043044)2.68765397
133negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.67226087
134response to UV-C (GO:0010225)2.66885659
135positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.66460686
136positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.66460686
137positive regulation of mitotic sister chromatid separation (GO:1901970)2.66460686
138valine metabolic process (GO:0006573)2.66177211
139positive regulation of lipid catabolic process (GO:0050996)2.65948550
140T-helper cell differentiation (GO:0042093)2.65770196
141CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.65770196
142regulation of triglyceride catabolic process (GO:0010896)2.65188853
143cholesterol efflux (GO:0033344)2.64243426
144positive regulation of histone H3-K4 methylation (GO:0051571)2.64219009
145very-low-density lipoprotein particle assembly (GO:0034379)2.63555619
146replicative senescence (GO:0090399)2.62833303
147regulation of helicase activity (GO:0051095)2.62804821
148prenylation (GO:0097354)2.62707765
149protein prenylation (GO:0018342)2.62707765
150phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.62528938
151negative regulation of B cell activation (GO:0050869)2.61552414
152DNA strand elongation involved in DNA replication (GO:0006271)2.61436382
153definitive hemopoiesis (GO:0060216)2.61281415
154positive regulation of histone methylation (GO:0031062)2.59082849
155cellular response to ethanol (GO:0071361)2.58743644
156bile acid metabolic process (GO:0008206)2.58641268
157positive regulation of SMAD protein import into nucleus (GO:0060391)2.58449086
158fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.58169231
159tyrosine metabolic process (GO:0006570)2.56621989
160indolalkylamine metabolic process (GO:0006586)2.56525166
161negative regulation of mitosis (GO:0045839)2.53974077
162diterpenoid biosynthetic process (GO:0016102)2.53339997
163low-density lipoprotein particle remodeling (GO:0034374)2.53012245
164regulation of dendritic cell antigen processing and presentation (GO:0002604)2.52334566
165regulation of MHC class II biosynthetic process (GO:0045346)2.51995503
166protein-lipid complex remodeling (GO:0034368)2.50148474
167macromolecular complex remodeling (GO:0034367)2.50148474
168plasma lipoprotein particle remodeling (GO:0034369)2.50148474
169positive regulation of fatty acid oxidation (GO:0046321)2.48649071
170lysine metabolic process (GO:0006553)2.43727333
171lysine catabolic process (GO:0006554)2.43727333
172negative regulation of lipid storage (GO:0010888)2.41316771
173regulation of immunoglobulin secretion (GO:0051023)2.40178974
174positive regulation of blood coagulation (GO:0030194)2.39116531
175positive regulation of hemostasis (GO:1900048)2.39116531
176negative regulation of fatty acid transport (GO:2000192)2.35706307
177regulation of regulatory T cell differentiation (GO:0045589)2.35385928
178positive regulation of T cell chemotaxis (GO:0010820)2.35007259
179regulation of T cell chemotaxis (GO:0010819)2.35007259
180plasma lipoprotein particle clearance (GO:0034381)2.34832967
181lipoprotein metabolic process (GO:0042157)2.34119364
182negative regulation of striated muscle cell apoptotic process (GO:0010664)2.33974081
183NIK/NF-kappaB signaling (GO:0038061)2.33864782
184aromatic amino acid family metabolic process (GO:0009072)2.33532293
185negative thymic T cell selection (GO:0045060)2.32167132
186fibrinolysis (GO:0042730)2.30924242
187epoxygenase P450 pathway (GO:0019373)2.30119789
188aldehyde catabolic process (GO:0046185)2.28219218
189positive regulation of cellular amide metabolic process (GO:0034250)2.25667967
190regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.25472397
191cytolysis (GO:0019835)2.25292958
192regulation of fatty acid beta-oxidation (GO:0031998)2.25082644
193regulation of interleukin-12 biosynthetic process (GO:0045075)2.24654301
194neural tube formation (GO:0001841)2.21493398
195positive regulation of coagulation (GO:0050820)2.21170899
196positive regulation of smooth muscle cell migration (GO:0014911)2.20973549
197acylglycerol homeostasis (GO:0055090)2.20043242
198triglyceride homeostasis (GO:0070328)2.20043242
199substrate-dependent cell migration (GO:0006929)2.18392454
200arginine metabolic process (GO:0006525)2.18239934

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.42174814
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.58051501
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.49423027
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.69114333
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.25327825
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.21800554
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.06758745
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.00332537
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.93413264
10AR_21909140_ChIP-Seq_LNCAP_Human2.86803989
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.78851539
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.75600914
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.55132880
14* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.54802940
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.53519732
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.52766627
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.45933066
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.37293718
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.28301421
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.26380209
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.22308724
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.20372957
23WT1_19549856_ChIP-ChIP_CCG9911_Human2.14800455
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.12323026
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07388171
26E2F1_21310950_ChIP-Seq_MCF-7_Human2.05895311
27NRF2_20460467_ChIP-Seq_MEFs_Mouse2.04980790
28NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.04980790
29ELK1_19687146_ChIP-ChIP_HELA_Human2.02512664
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.02386332
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.94032337
32ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.93290068
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.86823925
34CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.84939583
35* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81872015
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81346901
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.81306740
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.81269427
39EWS_26573619_Chip-Seq_HEK293_Human1.80194154
40CLOCK_20551151_ChIP-Seq_293T_Human1.74771140
41FUS_26573619_Chip-Seq_HEK293_Human1.74464596
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.73027955
43GATA1_22025678_ChIP-Seq_K562_Human1.71830128
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67403037
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67215784
46CJUN_26792858_Chip-Seq_BT549_Human1.66101760
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.63023836
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61995271
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.60871776
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.59907945
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57801777
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55766143
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54882675
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51411846
55RUNX_20019798_ChIP-Seq_JUKART_Human1.51332130
56SALL4_18804426_ChIP-ChIP_XEN_Mouse1.50695660
57IRF8_27001747_Chip-Seq_BMDM_Mouse1.50617394
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.50255106
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49993258
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.47921461
61KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46306355
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46076848
63FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.45355784
64* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44846169
65* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43388340
66* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42617516
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.42359030
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.41470040
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.40083869
70IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40040057
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.38231276
72TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.36505387
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35446253
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35381384
75TP53_18474530_ChIP-ChIP_U2OS_Human1.33285892
76PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32811705
77RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31117068
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.30584396
79SOX2_20726797_ChIP-Seq_SW620_Human1.29956315
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27453922
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.26536999
82* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.25719738
83BRD4_25478319_ChIP-Seq_HGPS_Human1.25120549
84SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23316079
85SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22175383
86VDR_24787735_ChIP-Seq_THP-1_Human1.21333447
87* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.21301927
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21082503
89HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17513286
90FOXO3_23340844_ChIP-Seq_DLD1_Human1.16987194
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15939786
92IGF1R_20145208_ChIP-Seq_DFB_Human1.15802122
93CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15441138
94* FOXA2_19822575_ChIP-Seq_HepG2_Human1.15119727
95NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13895303
96P300_19829295_ChIP-Seq_ESCs_Human1.12514846
97EGR1_19374776_ChIP-ChIP_THP-1_Human1.12474650
98* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11917903
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11855401
100SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11789300
101SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11789300
102KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.11057482
103KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.11057482
104KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.11057482
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11010718
106AHR_22903824_ChIP-Seq_MCF-7_Human1.10863874
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10831936
108STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08822461
109SOX17_20123909_ChIP-Seq_XEN_Mouse1.08320438
110ESR1_21235772_ChIP-Seq_MCF-7_Human1.07197012
111TP63_17297297_ChIP-ChIP_HaCaT_Human1.06573481
112TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.05287231
113RXR_22108803_ChIP-Seq_LS180_Human1.03069110
114FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02880262
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.02281253
116PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00735815
117TP63_23658742_ChIP-Seq_EP156T_Human1.00548377
118CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00320330
119VDR_23849224_ChIP-Seq_CD4+_Human0.99933692
120GBX2_23144817_ChIP-Seq_PC3_Human0.99452594
121MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97729326
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97508128
123SMAD4_21799915_ChIP-Seq_A2780_Human0.96061632
124SALL4_22934838_ChIP-ChIP_CD34+_Human0.95922626
125NANOG_16153702_ChIP-ChIP_HESCs_Human0.95133901
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94286056
127* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93671422
128BCAT_22108803_ChIP-Seq_LS180_Human0.93663078
129FOXP3_21729870_ChIP-Seq_TREG_Human0.93436715
130* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93381624
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93113149
132FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93006663
133HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92646747
134FLI1_27457419_Chip-Seq_LIVER_Mouse0.92645772
135PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.92602951
136SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92132922
137FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91097351
138HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.90961825
139AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90694336
140CHD1_26751641_Chip-Seq_LNCaP_Human0.89304933
141CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89204887
142FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.89182952
143ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89092342
144* TCF4_18268006_ChIP-ChIP_LS174T_Human0.88809417
145PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87886175
146EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87864283
147PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87521754
148PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86474093
149EST1_17652178_ChIP-ChIP_JURKAT_Human0.85881427
150TAF15_26573619_Chip-Seq_HEK293_Human0.85573300
151STAT4_19710469_ChIP-ChIP_TH1__Mouse0.85075467
152SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84734009
153* E2F1_18555785_Chip-Seq_ESCs_Mouse0.84625421
154SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84606245
155CDX2_22108803_ChIP-Seq_LS180_Human0.83720183
156CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83478575
157TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83228842
158TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83122107
159MYB_21317192_ChIP-Seq_ERMYB_Mouse0.82830217
160TBX3_20139965_ChIP-Seq_ESCs_Mouse0.82736606
161DCP1A_22483619_ChIP-Seq_HELA_Human0.82583522
162RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82308618
163RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.82291162
164EZH2_27294783_Chip-Seq_NPCs_Mouse0.82170911
165OCT4_18555785_Chip-Seq_ESCs_Mouse0.81935292
166GATA4_21415370_ChIP-Seq_HL-1_Mouse0.81528696
167* CMYC_18555785_Chip-Seq_ESCs_Mouse0.81446211
168TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80790016

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.96381748
2MP0002139_abnormal_hepatobiliary_system3.89701014
3MP0010094_abnormal_chromosome_stability3.76524268
4MP0005360_urolithiasis3.72803043
5MP0003941_abnormal_skin_development3.50321936
6MP0005085_abnormal_gallbladder_physiolo3.48694027
7MP0002138_abnormal_hepatobiliary_system3.36036750
8MP0008438_abnormal_cutaneous_collagen3.20804125
9MP0010234_abnormal_vibrissa_follicle3.16548999
10MP0004957_abnormal_blastocyst_morpholog3.13747290
11MP0003300_gastrointestinal_ulcer2.98138072
12MP0003705_abnormal_hypodermis_morpholog2.98067573
13MP0005365_abnormal_bile_salt2.91974533
14MP0003252_abnormal_bile_duct2.87570044
15MP0003890_abnormal_embryonic-extraembry2.79491475
16MP0003111_abnormal_nucleus_morphology2.64950427
17MP0003303_peritoneal_inflammation2.61972012
18MP0002796_impaired_skin_barrier2.61550036
19MP0001348_abnormal_lacrimal_gland2.53482954
20MP0001835_abnormal_antigen_presentation2.49004213
21MP0003077_abnormal_cell_cycle2.25902060
22MP0009053_abnormal_anal_canal2.20368755
23MP0002009_preneoplasia2.19171180
24MP0002396_abnormal_hematopoietic_system2.18386807
25MP0003806_abnormal_nucleotide_metabolis2.12936726
26MP0010368_abnormal_lymphatic_system2.11084194
27MP0001879_abnormal_lymphatic_vessel2.07159058
28MP0003693_abnormal_embryo_hatching2.06098510
29MP0004510_myositis2.05726679
30MP0005083_abnormal_biliary_tract1.94594649
31MP0005451_abnormal_body_composition1.91612382
32MP0001661_extended_life_span1.90531996
33MP0008058_abnormal_DNA_repair1.87050764
34MP0001730_embryonic_growth_arrest1.86652040
35MP0008875_abnormal_xenobiotic_pharmacok1.85237287
36MP0008007_abnormal_cellular_replicative1.84210651
37MP0000569_abnormal_digit_pigmentation1.79496599
38MP0002166_altered_tumor_susceptibility1.79258243
39MP0004185_abnormal_adipocyte_glucose1.77539412
40MP0005503_abnormal_tendon_morphology1.68972320
41MP0005671_abnormal_response_to1.68756487
42MP0005408_hypopigmentation1.66848314
43MP0003984_embryonic_growth_retardation1.63411410
44MP0001672_abnormal_embryogenesis/_devel1.62835851
45MP0005380_embryogenesis_phenotype1.62835851
46MP0008932_abnormal_embryonic_tissue1.62671963
47MP0003567_abnormal_fetal_cardiomyocyte1.62069841
48MP0005275_abnormal_skin_tensile1.60913438
49MP0002088_abnormal_embryonic_growth/wei1.60894816
50MP0001790_abnormal_immune_system1.59270873
51MP0005387_immune_system_phenotype1.59270873
52MP0002006_tumorigenesis1.58780521
53MP0009672_abnormal_birth_weight1.57516434
54MP0001873_stomach_inflammation1.57203317
55MP0010307_abnormal_tumor_latency1.55016551
56MP0001697_abnormal_embryo_size1.51572265
57MP0005501_abnormal_skin_physiology1.49376711
58MP0003195_calcinosis1.48274166
59MP0002086_abnormal_extraembryonic_tissu1.47561404
60MP0010678_abnormal_skin_adnexa1.45987295
61MP0003279_aneurysm1.45450211
62MP0010329_abnormal_lipoprotein_level1.45258992
63MP0003221_abnormal_cardiomyocyte_apopto1.44900534
64MP0000350_abnormal_cell_proliferation1.43154107
65MP0002084_abnormal_developmental_patter1.38597089
66MP0005248_abnormal_Harderian_gland1.36503152
67MP0002877_abnormal_melanocyte_morpholog1.36059108
68MP0005332_abnormal_amino_acid1.35671937
69MP0003718_maternal_effect1.31406661
70MP0001853_heart_inflammation1.30898203
71MP0009384_cardiac_valve_regurgitation1.29911944
72MP0009697_abnormal_copulation1.27484283
73MP0004264_abnormal_extraembryonic_tissu1.25768408
74MP0003937_abnormal_limbs/digits/tail_de1.25017692
75MP0010352_gastrointestinal_tract_polyps1.21286277
76MP0001915_intracranial_hemorrhage1.20705584
77MP0001177_atelectasis1.20673330
78MP0004197_abnormal_fetal_growth/weight/1.20474787
79MP0006082_CNS_inflammation1.20096892
80MP0002148_abnormal_hypersensitivity_rea1.17850410
81MP0000685_abnormal_immune_system1.17547708
82MP0000428_abnormal_craniofacial_morphol1.16846160
83MP0003656_abnormal_erythrocyte_physiolo1.16546024
84MP0002697_abnormal_eye_size1.16434941
85MP0005367_renal/urinary_system_phenotyp1.14818893
86MP0000516_abnormal_urinary_system1.14818893
87MP0003191_abnormal_cellular_cholesterol1.14571289
88MP0002080_prenatal_lethality1.14013431
89MP0003943_abnormal_hepatobiliary_system1.13974442
90MP0001958_emphysema1.13888920
91MP0005084_abnormal_gallbladder_morpholo1.13075202
92MP0009703_decreased_birth_body1.11446093
93MP0004036_abnormal_muscle_relaxation1.09783405
94MP0010630_abnormal_cardiac_muscle1.09016749
95MP0001346_abnormal_lacrimal_gland1.08778136
96MP0002254_reproductive_system_inflammat1.08712883
97MP0009785_altered_susceptibility_to1.08299955
98MP0009764_decreased_sensitivity_to1.07585770
99MP0001216_abnormal_epidermal_layer1.04985979
100MP0004215_abnormal_myocardial_fiber1.04018651
101MP0005310_abnormal_salivary_gland1.03526505
102MP0003091_abnormal_cell_migration1.03464353
103MP0001293_anophthalmia1.03063025
104MP0002085_abnormal_embryonic_tissue1.02281964
105MP0004808_abnormal_hematopoietic_stem1.02172160
106MP0005076_abnormal_cell_differentiation1.01957943
107MP0003453_abnormal_keratinocyte_physiol1.00879753
108MP0000767_abnormal_smooth_muscle1.00589235
109MP0002295_abnormal_pulmonary_circulatio0.99681574
110MP0000383_abnormal_hair_follicle0.99122240
111MP0004782_abnormal_surfactant_physiolog0.99014811
112MP0002269_muscular_atrophy0.98973750
113MP0002092_abnormal_eye_morphology0.97715529
114MP0004147_increased_porphyrin_level0.96646254
115MP0003385_abnormal_body_wall0.96463334
116MP0004084_abnormal_cardiac_muscle0.96035523
117MP0003436_decreased_susceptibility_to0.95516311
118MP0004233_abnormal_muscle_weight0.95312673
119MP0004272_abnormal_basement_membrane0.93927328
120MP0003786_premature_aging0.93538744
121MP0005023_abnormal_wound_healing0.92888689
122MP0002928_abnormal_bile_duct0.92857029
123MP0002332_abnormal_exercise_endurance0.92787771
124MP0008775_abnormal_heart_ventricle0.92395737
125MP0003942_abnormal_urinary_system0.92191533
126MP0006138_congestive_heart_failure0.91735242
127MP0003186_abnormal_redox_activity0.91415482
128MP0005623_abnormal_meninges_morphology0.90628769
129MP0003566_abnormal_cell_adhesion0.90620161
130MP0004883_abnormal_blood_vessel0.90518317
131MP0001800_abnormal_humoral_immune0.89301284
132MP0002128_abnormal_blood_circulation0.88221054
133MP0001666_abnormal_nutrient_absorption0.88150871
134MP0003868_abnormal_feces_composition0.87641672
135MP0005171_absent_coat_pigmentation0.86269034
136MP0001191_abnormal_skin_condition0.85582884
137MP0000609_abnormal_liver_physiology0.85527612
138MP0005319_abnormal_enzyme/_coenzyme0.85108128
139MP0003950_abnormal_plasma_membrane0.83474494
140MP0002118_abnormal_lipid_homeostasis0.82428563
141MP0002933_joint_inflammation0.82235564
142MP0001286_abnormal_eye_development0.80269596
143MP0003935_abnormal_craniofacial_develop0.79619788
144MP0005000_abnormal_immune_tolerance0.79496839
145MP0003448_altered_tumor_morphology0.78909928
146MP0000598_abnormal_liver_morphology0.78833706
147MP0006054_spinal_hemorrhage0.78645495
148MP0002060_abnormal_skin_morphology0.78313965
149MP0000377_abnormal_hair_follicle0.77290298
150MP0005584_abnormal_enzyme/coenzyme_acti0.77239492
151MP0002163_abnormal_gland_morphology0.76555323
152MP0004130_abnormal_muscle_cell0.76315231
153MP0001544_abnormal_cardiovascular_syste0.76152216
154MP0005385_cardiovascular_system_phenoty0.76152216
155MP0000579_abnormal_nail_morphology0.75250297
156MP0002972_abnormal_cardiac_muscle0.75052060
157MP0000313_abnormal_cell_death0.74812343
158MP0000249_abnormal_blood_vessel0.74552499
159MP0001542_abnormal_bone_strength0.74234097
160MP0009763_increased_sensitivity_to0.73836897
161MP0005197_abnormal_uvea_morphology0.73361657
162MP0001764_abnormal_homeostasis0.73232683
163MP0004087_abnormal_muscle_fiber0.73192317
164MP0000647_abnormal_sebaceous_gland0.71998294
165MP0000432_abnormal_head_morphology0.71197225
166MP0002452_abnormal_antigen_presenting0.71193264
167MP0001881_abnormal_mammary_gland0.70644281
168MP0000566_synostosis0.70140281
169MP0001188_hyperpigmentation0.69995796
170MP0002095_abnormal_skin_pigmentation0.68613757
171MP0005330_cardiomyopathy0.68539860
172MP0001784_abnormal_fluid_regulation0.65109633
173MP0001299_abnormal_eye_distance/0.63742522
174MP0003646_muscle_fatigue0.62974758
175MP0005621_abnormal_cell_physiology0.61444226
176MP0002019_abnormal_tumor_incidence0.61308702
177MP0005666_abnormal_adipose_tissue0.60824920
178MP0002233_abnormal_nose_morphology0.60132514

Predicted human phenotypes

RankGene SetZ-score
1Optic neuritis (HP:0100653)4.82645039
2Retrobulbar optic neuritis (HP:0100654)4.82645039
3Orchitis (HP:0100796)4.23925007
4Deep venous thrombosis (HP:0002625)4.21892301
5Acanthocytosis (HP:0001927)3.75827029
6Chromsome breakage (HP:0040012)3.71731961
7Nephroblastoma (Wilms tumor) (HP:0002667)3.71333948
8Epidermoid cyst (HP:0200040)3.61535612
9Arterial thrombosis (HP:0004420)3.61161381
10Hypobetalipoproteinemia (HP:0003563)3.54468076
11Intrahepatic cholestasis (HP:0001406)3.53477965
12Embryonal renal neoplasm (HP:0011794)3.51464849
13B lymphocytopenia (HP:0010976)3.48835805
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.48454385
15Keratoconjunctivitis sicca (HP:0001097)3.46595015
16Pulmonary embolism (HP:0002204)3.40989460
17Aortic aneurysm (HP:0004942)3.34486655
18Myocardial infarction (HP:0001658)3.29274179
19Thrombophlebitis (HP:0004418)3.23267276
20Asymmetry of the thorax (HP:0001555)3.21386638
21Hepatocellular carcinoma (HP:0001402)3.20020452
22Abnormality of the common coagulation pathway (HP:0010990)3.16114722
23Syringomyelia (HP:0003396)3.14575538
24Spinal cord lesions (HP:0100561)3.14575538
25Myositis (HP:0100614)3.10466192
26Abnormality of the left ventricular outflow tract (HP:0011103)3.07504870
27Subaortic stenosis (HP:0001682)3.07504870
28Keratoconjunctivitis (HP:0001096)3.03814264
29Hepatoblastoma (HP:0002884)3.02783313
30Pulmonary infiltrates (HP:0002113)3.01773485
31Papillary thyroid carcinoma (HP:0002895)3.00310827
32Hypoplasia of the thymus (HP:0000778)3.00003161
33Subacute progressive viral hepatitis (HP:0006572)2.97417122
34Biliary tract neoplasm (HP:0100574)2.92649497
35Erythroderma (HP:0001019)2.92539640
36Abnormality of monocarboxylic acid metabolism (HP:0010996)2.91432194
37Complement deficiency (HP:0004431)2.89733468
38Spontaneous abortion (HP:0005268)2.86956624
39Neoplasm of the small intestine (HP:0100833)2.85907712
40Acute myeloid leukemia (HP:0004808)2.84976549
41Gangrene (HP:0100758)2.83906021
42Xanthomatosis (HP:0000991)2.83787625
43Abnormality of B cell number (HP:0010975)2.83727403
44Abnormality of glutamine family amino acid metabolism (HP:0010902)2.82267823
45Acute hepatic failure (HP:0006554)2.81175512
46Prolonged partial thromboplastin time (HP:0003645)2.80335981
47Abnormality of aromatic amino acid family metabolism (HP:0004338)2.77629404
48Mitral stenosis (HP:0001718)2.75292097
49Vasculitis (HP:0002633)2.75008601
50Ankyloglossia (HP:0010296)2.73730461
51Abnormality of chromosome stability (HP:0003220)2.68839915
52Gastrointestinal carcinoma (HP:0002672)2.65732363
53Malignant gastrointestinal tract tumors (HP:0006749)2.65732363
54Progressive external ophthalmoplegia (HP:0000590)2.64833943
55Rhabdomyosarcoma (HP:0002859)2.63957401
56Peritonitis (HP:0002586)2.61461807
57Curly hair (HP:0002212)2.58517827
58Combined immunodeficiency (HP:0005387)2.57737960
59Hypolipoproteinemia (HP:0010981)2.52980213
60Autoimmune thrombocytopenia (HP:0001973)2.50415088
61Selective tooth agenesis (HP:0001592)2.46909533
62T lymphocytopenia (HP:0005403)2.46667301
63Thyroid carcinoma (HP:0002890)2.46547790
64Right ventricular cardiomyopathy (HP:0011663)2.40961834
65Abnormal lung lobation (HP:0002101)2.39716568
66Abnormality of the pericardium (HP:0001697)2.39458025
67Joint hemorrhage (HP:0005261)2.37854161
68Severe combined immunodeficiency (HP:0004430)2.36578949
69Gastrointestinal infarctions (HP:0005244)2.36150921
70Thyroiditis (HP:0100646)2.35723707
71Pancreatic islet-cell hyperplasia (HP:0004510)2.33864659
72Esophageal varix (HP:0002040)2.33545071
73Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.30293206
74Aortic dissection (HP:0002647)2.29567950
75Ovarian neoplasm (HP:0100615)2.29496300
76Gingival bleeding (HP:0000225)2.29027286
77Uterine leiomyosarcoma (HP:0002891)2.28133778
78Leiomyosarcoma (HP:0100243)2.28133778
79Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.28080035
80Embryonal neoplasm (HP:0002898)2.25426646
81Panhypogammaglobulinemia (HP:0003139)2.25133445
82Uterine neoplasm (HP:0010784)2.23692768
83Nemaline bodies (HP:0003798)2.23637996
84Hypoglycemic coma (HP:0001325)2.21549768
85Abnormality of complement system (HP:0005339)2.21112013
86Neoplasm of the colon (HP:0100273)2.21044201
87Transitional cell carcinoma of the bladder (HP:0006740)2.19753816
88Neoplasm of the adrenal gland (HP:0100631)2.19174566
89Abnormality of the axillary hair (HP:0100134)2.18924168
90Abnormality of secondary sexual hair (HP:0009888)2.18924168
91Medulloblastoma (HP:0002885)2.18193282
92Glomerulopathy (HP:0100820)2.18039045
93Vascular tortuosity (HP:0004948)2.17848539
94Hemoptysis (HP:0002105)2.16156140
95Alveolar cell carcinoma (HP:0006519)2.13444941
96Joint swelling (HP:0001386)2.13408934
97Muscle fiber inclusion bodies (HP:0100299)2.12056615
98Neoplasm of the adrenal cortex (HP:0100641)2.10860403
99Multiple enchondromatosis (HP:0005701)2.09453505
100Insidious onset (HP:0003587)2.08363987
101Termporal pattern (HP:0011008)2.08363987
102Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.08273376
103Abnormal biliary tract morphology (HP:0012440)2.08154959
104Abnormality of proline metabolism (HP:0010907)2.07979725
105Hydroxyprolinuria (HP:0003080)2.07979725
106Increased IgM level (HP:0003496)2.07321134
107Abnormality of the prostate (HP:0008775)2.06597467
108Bladder carcinoma (HP:0002862)2.06096478
109Bladder neoplasm (HP:0009725)2.06096478
110Abnormality of oral frenula (HP:0000190)2.05109094
111Increased mean platelet volume (HP:0011877)2.04057301
112Volvulus (HP:0002580)2.03678296
113Tetraparesis (HP:0002273)2.03666264
114Fat malabsorption (HP:0002630)2.03200461
115Neoplasm of the tracheobronchial system (HP:0100552)2.02355653
116Hypoalphalipoproteinemia (HP:0003233)2.02263689
117Increased nuchal translucency (HP:0010880)2.02140502
118Hypochromic microcytic anemia (HP:0004840)2.02045742
119Hyperlipoproteinemia (HP:0010980)2.01705448
120Pancreatitis (HP:0001733)2.01473142
121Bilateral sensorineural hearing impairment (HP:0008619)1.99063129
122Neoplasm of the rectum (HP:0100743)1.98699099
123Missing ribs (HP:0000921)1.98459871
124Hypercholesterolemia (HP:0003124)1.97782562
125Chest pain (HP:0100749)1.97755816
126Abnormality of methionine metabolism (HP:0010901)1.97430173
127Chorioretinal atrophy (HP:0000533)1.97162332
128Abnormality of the pleura (HP:0002103)1.96199006
129Overlapping toe (HP:0001845)1.94718793
130Hypoproteinemia (HP:0003075)1.94635398
131Abnormality of the preputium (HP:0100587)1.94306511
132Cystic hygroma (HP:0000476)1.93073992
133Dilatation of the ascending aorta (HP:0005111)1.91702809
134Orthostatic hypotension (HP:0001278)1.90513602
135Short middle phalanx of the 5th finger (HP:0004220)1.89983303
136Abnormality of T cell number (HP:0011839)1.88931003
137Abnormality of nail color (HP:0100643)1.88555947
138Abnormality of the intrinsic pathway (HP:0010989)1.87747942
139Fair hair (HP:0002286)1.87388964
140Decreased lacrimation (HP:0000633)1.86873191
141Aplasia involving bones of the extremities (HP:0009825)1.85594776
142Aplasia involving bones of the upper limbs (HP:0009823)1.85594776
143Aplasia of the phalanges of the hand (HP:0009802)1.85594776
144Osteolytic defects of the phalanges of the hand (HP:0009771)1.85342967
145Osteolytic defects of the hand bones (HP:0009699)1.85342967
146Abnormal platelet volume (HP:0011876)1.85296684
147Sandal gap (HP:0001852)1.84903476
148Abnormality of sulfur amino acid metabolism (HP:0004339)1.83991381
149Conjugated hyperbilirubinemia (HP:0002908)1.83887967
150Palmar hyperkeratosis (HP:0010765)1.83875367
151Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83701840
152Deep philtrum (HP:0002002)1.83632403
153Cardiovascular calcification (HP:0011915)1.83043632
154Colon cancer (HP:0003003)1.82942952
155Alacrima (HP:0000522)1.81968085
156Abnormal foot bone ossification (HP:0010675)1.81204557
157Abnormality of the salivary glands (HP:0010286)1.81057102
158Encephalitis (HP:0002383)1.81033114
15911 pairs of ribs (HP:0000878)1.79982424
160Lymphangioma (HP:0100764)1.79211869
161Recurrent gram-negative bacterial infections (HP:0005420)1.79097320
162Acute lymphatic leukemia (HP:0006721)1.77698341
163Enlarged kidneys (HP:0000105)1.77680699
164IgM deficiency (HP:0002850)1.77478279
165Duodenal stenosis (HP:0100867)1.77037196
166Small intestinal stenosis (HP:0012848)1.77037196
167Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.76476800
168Absent eyelashes (HP:0000561)1.76249235
169Clitoromegaly (HP:0000057)1.76127435
170Long clavicles (HP:0000890)1.75937564
171Poikilocytosis (HP:0004447)1.75207564
172Hematochezia (HP:0002573)1.74643117
173Meckel diverticulum (HP:0002245)1.74285342
174Systemic lupus erythematosus (HP:0002725)1.73723839
175Abnormality of chromosome segregation (HP:0002916)1.72870158
176Cerebral hemorrhage (HP:0001342)1.71840501
177Cortical dysplasia (HP:0002539)1.71778825
178Abnormality of the nasal septum (HP:0000419)1.71434045
179Mesomelia (HP:0003027)1.71114903
180Rimmed vacuoles (HP:0003805)1.70733601
181Absent eyebrow (HP:0002223)1.70082693
182Exercise-induced muscle cramps (HP:0003710)1.68583399
183Capillary hemangiomas (HP:0005306)1.68363692
184Palmoplantar hyperkeratosis (HP:0000972)1.68345594
185Cerebral ischemia (HP:0002637)1.66546800
186Conjunctival hamartoma (HP:0100780)1.66182245
187Skin nodule (HP:0200036)1.64966613
188Disinhibition (HP:0000734)1.64602559

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.79304012
2FRK3.74800624
3MAP3K143.62457727
4ZAK3.15535803
5EIF2AK33.15274030
6SCYL23.03402026
7MST42.80076986
8TTK2.67927794
9MKNK22.60957318
10SRPK12.57467288
11AKT32.56119493
12BRSK22.50031255
13ERBB32.49578669
14MKNK12.46739381
15CDC72.34381853
16NEK92.34040972
17MAP3K102.26169213
18BRD42.24354211
19JAK12.16468594
20TSSK62.14969564
21JAK32.07025236
22FGFR31.99539004
23SGK21.98299520
24EIF2AK11.97986504
25NUAK11.94395437
26BUB11.81604062
27PIK3CA1.78087006
28BCR1.77848820
29TIE11.77501978
30EEF2K1.75338256
31LATS11.73139374
32SGK31.65321802
33CHUK1.64482517
34PLK41.59381176
35TYK21.58809734
36BMPR21.58131998
37NLK1.56894683
38IKBKB1.50878621
39EPHA31.46268096
40NEK11.45125219
41TRPM71.41311305
42ACVR1B1.40218853
43TAF11.38794693
44JAK21.38184525
45WEE11.33264446
46FGFR21.29226671
47ERBB41.24829256
48FGFR41.22686785
49MYLK1.22601485
50RIPK11.22109583
51PTK61.21087500
52RPS6KB21.19219964
53OBSCN1.15675857
54PAK31.15392127
55SGK4941.14432753
56SGK2231.14432753
57TNIK1.14044141
58CDK121.10666679
59LATS21.09087524
60BMX1.07669228
61STK31.04750084
62STK241.04555388
63YES11.02347256
64EPHB21.02010194
65TGFBR11.01601630
66LIMK10.98150390
67CDK60.96306526
68SIK10.95003225
69TBK10.93381067
70MAP3K130.93125421
71BMPR1B0.91317610
72STK38L0.90288124
73VRK10.88943968
74EIF2AK20.88776956
75ATM0.87730016
76IKBKE0.86753240
77TRIM280.86679836
78PDGFRA0.86325730
79INSRR0.86168075
80WNK10.85316167
81TESK10.85197417
82ATR0.84226633
83PLK20.83733418
84CHEK20.83277073
85PKN20.81839128
86PLK10.78445881
87RPS6KA40.78432533
88PKN10.78279316
89PRKCQ0.76861389
90CDK40.76195541
91FGFR10.74390292
92KSR10.72112745
93CCNB10.72001816
94ALK0.70775849
95PRKCH0.70579259
96ROCK10.69148702
97AURKB0.68586264
98MAP3K120.67835282
99RAF10.66723278
100PIK3CG0.65569164
101STK40.65274513
102CLK10.63613188
103CHEK10.62866660
104STK390.61958942
105MAP3K40.60972497
106MET0.60557433
107DDR20.60336617
108PBK0.59945876
109RPS6KB10.56700087
110CSNK1A1L0.55002225
111MAP2K30.54457801
112IRAK40.54018803
113KSR20.53750014
114CDK70.52924303
115TRIB30.52460840
116MAP3K80.52312214
117MAP3K20.50949330
118TTN0.50306651
119PNCK0.48753970
120CSNK1E0.48631780
121PLK30.48486665
122PRKCE0.48190533
123BRAF0.47805039
124IGF1R0.46607454
125PTK2B0.45651238
126TEC0.45551872
127SGK10.45050249
128PDGFRB0.43460184
129MAPK110.43227134
130CDK10.42992618
131PRKAA20.41496653
132CDC42BPA0.40932945
133DMPK0.40861849
134CDK20.40726419
135MAP3K30.39786598
136RET0.39292759
137NEK20.38367696
138MAPKAPK50.37962164
139GSK3A0.37567238
140NEK60.36552891
141PIM10.35775269
142INSR0.35734728
143MELK0.35715650
144PRKCZ0.33198557
145PDK20.32876455
146IRAK10.32491963
147FLT30.32394070
148MAP3K50.31932154
149ZAP700.31776345
150MAPKAPK20.31469433
151AKT20.31120652
152MAP2K10.30903483
153PRKAA10.30821819
154CSNK2A20.29993146
155PRKACG0.29778059
156TGFBR20.29586612
157FER0.29375179
158ABL20.29321419
159PRKDC0.29020657
160AKT10.27820601

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.47939684
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.06220767
3Autoimmune thyroid disease_Homo sapiens_hsa053203.77901481
4Allograft rejection_Homo sapiens_hsa053303.52306985
5Primary bile acid biosynthesis_Homo sapiens_hsa001203.17414117
6Mismatch repair_Homo sapiens_hsa034303.02815431
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97529294
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.93586629
9Cell cycle_Homo sapiens_hsa041102.70939943
10RNA transport_Homo sapiens_hsa030132.55611831
11DNA replication_Homo sapiens_hsa030302.49696539
12Nitrogen metabolism_Homo sapiens_hsa009102.46736570
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.43504448
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.43481313
15Spliceosome_Homo sapiens_hsa030402.11869758
16Staphylococcus aureus infection_Homo sapiens_hsa051502.09357139
17mRNA surveillance pathway_Homo sapiens_hsa030152.08926408
18Complement and coagulation cascades_Homo sapiens_hsa046102.08583917
19Asthma_Homo sapiens_hsa053102.06244399
20Systemic lupus erythematosus_Homo sapiens_hsa053222.02762160
21Thyroid cancer_Homo sapiens_hsa052161.99847089
22Tryptophan metabolism_Homo sapiens_hsa003801.96791567
23Arginine biosynthesis_Homo sapiens_hsa002201.89965188
24One carbon pool by folate_Homo sapiens_hsa006701.80218556
25Nucleotide excision repair_Homo sapiens_hsa034201.79298575
26Homologous recombination_Homo sapiens_hsa034401.78883984
27Fanconi anemia pathway_Homo sapiens_hsa034601.71350532
28RNA degradation_Homo sapiens_hsa030181.66919318
29Fatty acid degradation_Homo sapiens_hsa000711.63653822
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.61215733
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.60410863
32Graft-versus-host disease_Homo sapiens_hsa053321.54929056
33Phenylalanine metabolism_Homo sapiens_hsa003601.50053752
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45287305
35Peroxisome_Homo sapiens_hsa041461.42733762
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38793945
37Leishmaniasis_Homo sapiens_hsa051401.37308539
38Basal transcription factors_Homo sapiens_hsa030221.37175992
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31879752
40p53 signaling pathway_Homo sapiens_hsa041151.31221585
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30416820
42Fatty acid biosynthesis_Homo sapiens_hsa000611.27655095
43Circadian rhythm_Homo sapiens_hsa047101.22158912
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22004241
45PPAR signaling pathway_Homo sapiens_hsa033201.21152809
46Alcoholism_Homo sapiens_hsa050341.19551325
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.19333022
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15235232
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.13769675
50Pyruvate metabolism_Homo sapiens_hsa006201.13270400
51Starch and sucrose metabolism_Homo sapiens_hsa005001.13204462
52Sulfur metabolism_Homo sapiens_hsa009201.13081716
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12949808
54Oocyte meiosis_Homo sapiens_hsa041141.12412259
55Colorectal cancer_Homo sapiens_hsa052101.12313909
56Viral carcinogenesis_Homo sapiens_hsa052031.12310479
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09944116
58Malaria_Homo sapiens_hsa051441.09312750
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09160073
60Renal cell carcinoma_Homo sapiens_hsa052111.07852131
61Selenocompound metabolism_Homo sapiens_hsa004501.06124883
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04850098
63Non-small cell lung cancer_Homo sapiens_hsa052231.02870148
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.02378136
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01181222
66Toxoplasmosis_Homo sapiens_hsa051451.01100578
67Fatty acid metabolism_Homo sapiens_hsa012121.00551126
68NF-kappa B signaling pathway_Homo sapiens_hsa040641.00043187
69Protein export_Homo sapiens_hsa030600.99916829
70Carbon metabolism_Homo sapiens_hsa012000.99873420
71Butanoate metabolism_Homo sapiens_hsa006500.99309744
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99060760
73Viral myocarditis_Homo sapiens_hsa054160.93358118
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.92094082
75Type I diabetes mellitus_Homo sapiens_hsa049400.92005314
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91057478
77Retinol metabolism_Homo sapiens_hsa008300.90356546
78Chemical carcinogenesis_Homo sapiens_hsa052040.90341744
79Tyrosine metabolism_Homo sapiens_hsa003500.89838261
80Biosynthesis of amino acids_Homo sapiens_hsa012300.89495144
81Inositol phosphate metabolism_Homo sapiens_hsa005620.89345454
82Vitamin digestion and absorption_Homo sapiens_hsa049770.88453441
83Measles_Homo sapiens_hsa051620.86447102
84Propanoate metabolism_Homo sapiens_hsa006400.85682944
85beta-Alanine metabolism_Homo sapiens_hsa004100.85270198
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85163091
87African trypanosomiasis_Homo sapiens_hsa051430.83737430
88Bile secretion_Homo sapiens_hsa049760.83564300
89TNF signaling pathway_Homo sapiens_hsa046680.82115102
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.81583276
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80025590
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79779816
93Renin-angiotensin system_Homo sapiens_hsa046140.79449542
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75561171
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75130067
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74693543
97Pertussis_Homo sapiens_hsa051330.73004169
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71421981
99Histidine metabolism_Homo sapiens_hsa003400.71257705
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70979926
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70922469
102Wnt signaling pathway_Homo sapiens_hsa043100.70705939
103Glioma_Homo sapiens_hsa052140.67157549
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.67077134
105Dilated cardiomyopathy_Homo sapiens_hsa054140.65656187
106T cell receptor signaling pathway_Homo sapiens_hsa046600.65257195
107mTOR signaling pathway_Homo sapiens_hsa041500.65185383
108Adherens junction_Homo sapiens_hsa045200.64800990
109Amoebiasis_Homo sapiens_hsa051460.63333595
110B cell receptor signaling pathway_Homo sapiens_hsa046620.61791713
111FoxO signaling pathway_Homo sapiens_hsa040680.60854519
112Rheumatoid arthritis_Homo sapiens_hsa053230.60773006
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59613992
114Focal adhesion_Homo sapiens_hsa045100.58784448
115HTLV-I infection_Homo sapiens_hsa051660.58719499
116Caffeine metabolism_Homo sapiens_hsa002320.58551212
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57724889
118ErbB signaling pathway_Homo sapiens_hsa040120.56996047
119Steroid biosynthesis_Homo sapiens_hsa001000.56899544
120Endometrial cancer_Homo sapiens_hsa052130.56854784
121Legionellosis_Homo sapiens_hsa051340.56416530
122Insulin signaling pathway_Homo sapiens_hsa049100.55580063
123Apoptosis_Homo sapiens_hsa042100.54730509
124Lysine degradation_Homo sapiens_hsa003100.54726942
125Proteoglycans in cancer_Homo sapiens_hsa052050.53977684
126Influenza A_Homo sapiens_hsa051640.53609483
127Pentose phosphate pathway_Homo sapiens_hsa000300.53586259
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53318639
129Insulin resistance_Homo sapiens_hsa049310.52542551
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51680570
131Hippo signaling pathway_Homo sapiens_hsa043900.51338117
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49959944
133Chemokine signaling pathway_Homo sapiens_hsa040620.49916694
134TGF-beta signaling pathway_Homo sapiens_hsa043500.48841302
135Prion diseases_Homo sapiens_hsa050200.48764773
136Prostate cancer_Homo sapiens_hsa052150.47213314
137Prolactin signaling pathway_Homo sapiens_hsa049170.47104791
138Base excision repair_Homo sapiens_hsa034100.46650750
139Chronic myeloid leukemia_Homo sapiens_hsa052200.46423028
140Tight junction_Homo sapiens_hsa045300.46374686
141Platelet activation_Homo sapiens_hsa046110.46295720
142ABC transporters_Homo sapiens_hsa020100.45597175
143HIF-1 signaling pathway_Homo sapiens_hsa040660.44405657
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.44341734
145RNA polymerase_Homo sapiens_hsa030200.44246452
146Tuberculosis_Homo sapiens_hsa051520.43842805
147Choline metabolism in cancer_Homo sapiens_hsa052310.42834077
148Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40470166
149Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40435484
150MicroRNAs in cancer_Homo sapiens_hsa052060.40155230
151Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38812188
152Osteoclast differentiation_Homo sapiens_hsa043800.38532492
153Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38508894
154Pathways in cancer_Homo sapiens_hsa052000.37501711
155Pancreatic cancer_Homo sapiens_hsa052120.37205439
156Long-term potentiation_Homo sapiens_hsa047200.36874663
157Hepatitis C_Homo sapiens_hsa051600.35895495
158Small cell lung cancer_Homo sapiens_hsa052220.35598868
159N-Glycan biosynthesis_Homo sapiens_hsa005100.34902738
160Epstein-Barr virus infection_Homo sapiens_hsa051690.34101033
161Herpes simplex infection_Homo sapiens_hsa051680.33625823
162Leukocyte transendothelial migration_Homo sapiens_hsa046700.33521743
163AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32786964
164Hepatitis B_Homo sapiens_hsa051610.32448055
165Purine metabolism_Homo sapiens_hsa002300.31784305
166Melanoma_Homo sapiens_hsa052180.31154618
167Sphingolipid metabolism_Homo sapiens_hsa006000.29825377
168Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29155598
169Glucagon signaling pathway_Homo sapiens_hsa049220.28998685

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