ARL5C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.24662183
2positive regulation of gamma-delta T cell activation (GO:0046645)5.43589232
3DNA deamination (GO:0045006)5.29239853
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.96662001
5neutrophil activation involved in immune response (GO:0002283)4.84495870
6NIK/NF-kappaB signaling (GO:0038061)4.57244179
7neutrophil activation (GO:0042119)4.38655966
8positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.19964487
9granulocyte activation (GO:0036230)4.16545294
10base-excision repair, AP site formation (GO:0006285)4.10441435
11regulation of cilium movement (GO:0003352)4.03913920
12axonemal dynein complex assembly (GO:0070286)3.95857317
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.89902661
14mitochondrial respiratory chain complex I assembly (GO:0032981)3.89902661
15NADH dehydrogenase complex assembly (GO:0010257)3.89902661
16fucose catabolic process (GO:0019317)3.87340510
17L-fucose metabolic process (GO:0042354)3.87340510
18L-fucose catabolic process (GO:0042355)3.87340510
19response to peptidoglycan (GO:0032494)3.86280043
20positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.86109994
21regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.83551057
22regulation of gamma-delta T cell activation (GO:0046643)3.82815631
23axoneme assembly (GO:0035082)3.78889559
24epithelial cilium movement (GO:0003351)3.77581355
25positive regulation of alpha-beta T cell proliferation (GO:0046641)3.74288576
26regulation of microtubule-based movement (GO:0060632)3.73919212
27negative regulation of telomere maintenance (GO:0032205)3.73435864
28protein complex biogenesis (GO:0070271)3.72403322
29regulation of gamma-delta T cell differentiation (GO:0045586)3.70424133
30B cell receptor signaling pathway (GO:0050853)3.69695912
31regulation of alpha-beta T cell proliferation (GO:0046640)3.68309291
32positive regulation of B cell differentiation (GO:0045579)3.68249849
33regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.67901521
34cilium or flagellum-dependent cell motility (GO:0001539)3.67435411
35positive regulation of interleukin-2 production (GO:0032743)3.60439625
36response to muramyl dipeptide (GO:0032495)3.50656665
37modulation by symbiont of host defense response (GO:0052031)3.45599833
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.45599833
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.45599833
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.45599833
41modulation by symbiont of host immune response (GO:0052553)3.45599833
42positive regulation by symbiont of host defense response (GO:0052509)3.45599833
43nonmotile primary cilium assembly (GO:0035058)3.45408496
44cilium movement (GO:0003341)3.45354175
45pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.45217868
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.43869995
47mitochondrial respiratory chain complex assembly (GO:0033108)3.43164613
48sequestering of actin monomers (GO:0042989)3.39450290
49T cell migration (GO:0072678)3.38606279
50synaptic transmission, cholinergic (GO:0007271)3.34624538
51platelet dense granule organization (GO:0060155)3.32888517
52ATP synthesis coupled proton transport (GO:0015986)3.32315192
53energy coupled proton transport, down electrochemical gradient (GO:0015985)3.32315192
54V(D)J recombination (GO:0033151)3.28109447
55macrophage activation involved in immune response (GO:0002281)3.27751785
56regulation of B cell differentiation (GO:0045577)3.26964833
57myeloid dendritic cell activation (GO:0001773)3.25266319
58immunoglobulin mediated immune response (GO:0016064)3.20747942
59gamma-aminobutyric acid transport (GO:0015812)3.19993076
60myeloid dendritic cell differentiation (GO:0043011)3.19315010
61interferon-gamma production (GO:0032609)3.14413522
62cellular response to interferon-beta (GO:0035458)3.14045577
63regulation of interleukin-12 biosynthetic process (GO:0045075)3.12987482
64cytidine deamination (GO:0009972)3.12485771
65cytidine metabolic process (GO:0046087)3.12485771
66cytidine catabolic process (GO:0006216)3.12485771
67antigen processing and presentation of endogenous antigen (GO:0019883)3.12252411
68natural killer cell mediated cytotoxicity (GO:0042267)3.11584363
69natural killer cell mediated immunity (GO:0002228)3.11584363
70mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.10068997
71positive regulation of interleukin-12 production (GO:0032735)3.09980469
72response to pheromone (GO:0019236)3.09478335
73positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.08936517
74positive regulation of T cell cytokine production (GO:0002726)3.08833680
75mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.08195548
76regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.07827554
77pyrimidine nucleobase catabolic process (GO:0006208)3.07523641
78positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.01743934
79regulation of interleukin-2 biosynthetic process (GO:0045076)3.00872821
80natural killer cell activation (GO:0030101)3.00189681
81cellular response to type I interferon (GO:0071357)2.99875371
82type I interferon signaling pathway (GO:0060337)2.99875371
83RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99142438
84tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99142438
85response to type I interferon (GO:0034340)2.98986937
86negative regulation of synaptic transmission, GABAergic (GO:0032229)2.98277378
87regulation of activation of Janus kinase activity (GO:0010533)2.94689151
88regulation of T-helper 1 cell differentiation (GO:0045625)2.93961454
89positive regulation of interferon-alpha production (GO:0032727)2.93525651
90regulation of action potential (GO:0098900)2.93507030
91regulation of antigen processing and presentation (GO:0002577)2.92626969
92negative T cell selection (GO:0043383)2.90850405
93water-soluble vitamin biosynthetic process (GO:0042364)2.90796902
94defense response to protozoan (GO:0042832)2.90500209
95positive regulation of mast cell degranulation (GO:0043306)2.90265343
96positive regulation of mast cell activation involved in immune response (GO:0033008)2.90265343
97activated T cell proliferation (GO:0050798)2.90076763
98B cell proliferation (GO:0042100)2.89754905
99detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.89658194
100positive regulation of antigen processing and presentation (GO:0002579)2.88120334
101regulation of B cell receptor signaling pathway (GO:0050855)2.87931520
102negative regulation of mast cell activation (GO:0033004)2.86613812
103pyrimidine nucleotide catabolic process (GO:0006244)2.85172771
104interferon-gamma-mediated signaling pathway (GO:0060333)2.84858183
105antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.84413438
106antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.84413438
107protein-cofactor linkage (GO:0018065)2.84214990
108sulfation (GO:0051923)2.83372034
109myeloid cell activation involved in immune response (GO:0002275)2.83362711
110T cell selection (GO:0045058)2.83254480
111preassembly of GPI anchor in ER membrane (GO:0016254)2.82798964
112response to interferon-beta (GO:0035456)2.82480926
113regulation of dendritic cell antigen processing and presentation (GO:0002604)2.81769409
114natural killer cell activation involved in immune response (GO:0002323)2.81381452
115nephron tubule morphogenesis (GO:0072078)2.80936117
116nephron epithelium morphogenesis (GO:0072088)2.80936117
117protein polyglutamylation (GO:0018095)2.80721008
118positive regulation of interleukin-17 production (GO:0032740)2.78447907
119leukocyte aggregation (GO:0070486)2.78302144
120regulation of interferon-alpha production (GO:0032647)2.78282177
121indolalkylamine metabolic process (GO:0006586)2.78169268
122transmission of nerve impulse (GO:0019226)2.77293992
123neuronal action potential (GO:0019228)2.76906790
124intraciliary transport (GO:0042073)2.76805286
125regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.74840818
126positive regulation of protein homooligomerization (GO:0032464)2.73554982
127cellular response to zinc ion (GO:0071294)2.73356780
128positive regulation of cytokine biosynthetic process (GO:0042108)2.72383653
129natural killer cell differentiation (GO:0001779)2.71815621
130germinal center formation (GO:0002467)2.71611970
131respiratory burst (GO:0045730)2.71611672
132I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.71535921
133somite development (GO:0061053)2.71493410
134indole-containing compound catabolic process (GO:0042436)2.71492622
135indolalkylamine catabolic process (GO:0046218)2.71492622
136tryptophan catabolic process (GO:0006569)2.71492622
137S-adenosylmethionine metabolic process (GO:0046500)2.71136839
138positive regulation of T-helper cell differentiation (GO:0045624)2.70631422
139lipopolysaccharide-mediated signaling pathway (GO:0031663)2.70351394
140regulation of mast cell degranulation (GO:0043304)2.70136512
141positive regulation of isotype switching (GO:0045830)2.70045881
142negative thymic T cell selection (GO:0045060)2.69899159
143electron transport chain (GO:0022900)2.68969425
144regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.68869152
145negative regulation of cell killing (GO:0031342)2.68858677
146negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.68858677
147B cell mediated immunity (GO:0019724)2.68756935
148positive regulation of defense response to virus by host (GO:0002230)2.68360872
149mannosylation (GO:0097502)2.68020272
150negative regulation of transcription regulatory region DNA binding (GO:2000678)2.67686827
151positive regulation of fatty acid transport (GO:2000193)2.67608448
152retinal cone cell development (GO:0046549)2.67389609
153dopamine transport (GO:0015872)2.66854919
154ubiquinone biosynthetic process (GO:0006744)2.66659400
155regulation of RIG-I signaling pathway (GO:0039535)2.65097173
156dendritic cell chemotaxis (GO:0002407)2.64922295
157rRNA catabolic process (GO:0016075)2.64317378
158regulation of immunoglobulin secretion (GO:0051023)2.64288875
159regulation of interleukin-2 production (GO:0032663)2.64114745
160piRNA metabolic process (GO:0034587)2.63884575
161cellular response to exogenous dsRNA (GO:0071360)2.63816276
162establishment of protein localization to mitochondrial membrane (GO:0090151)2.63510798
163positive regulation of mast cell activation (GO:0033005)2.63107071
164respiratory electron transport chain (GO:0022904)2.61971346
165pyrimidine ribonucleoside catabolic process (GO:0046133)2.61718394
166central nervous system myelination (GO:0022010)2.61612679
167axon ensheathment in central nervous system (GO:0032291)2.61612679
168kynurenine metabolic process (GO:0070189)2.61142730
169antigen receptor-mediated signaling pathway (GO:0050851)2.60719974
170positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.60255686
171myeloid leukocyte activation (GO:0002274)2.59988584
172detection of light stimulus involved in sensory perception (GO:0050962)2.59602084
173detection of light stimulus involved in visual perception (GO:0050908)2.59602084
174ubiquinone metabolic process (GO:0006743)2.58900215
175photoreceptor cell development (GO:0042461)2.58764121
176regulation of MHC class I biosynthetic process (GO:0045343)2.58442180
177ribosomal small subunit assembly (GO:0000028)2.58238935
178regulation of T cell cytokine production (GO:0002724)2.57470952
179T cell activation involved in immune response (GO:0002286)2.57330750
180T-helper cell differentiation (GO:0042093)2.55624350
181cilium morphogenesis (GO:0060271)2.54758886
182cilium organization (GO:0044782)2.54537370
183negative regulation by host of viral transcription (GO:0043922)2.52145613
184tryptophan metabolic process (GO:0006568)2.50687745
185nucleobase catabolic process (GO:0046113)2.49945579
186anterograde axon cargo transport (GO:0008089)2.48197937
187cilium assembly (GO:0042384)2.46386123
188regulation of telomere maintenance (GO:0032204)2.44848494
189reflex (GO:0060004)2.43992124
190protein import into peroxisome matrix (GO:0016558)2.43677566
191pseudouridine synthesis (GO:0001522)2.43353831
192deoxyribonucleotide catabolic process (GO:0009264)2.41895111
193amine catabolic process (GO:0009310)2.41848369
194cellular biogenic amine catabolic process (GO:0042402)2.41848369
195neural tube formation (GO:0001841)2.40606945
196negative regulation of cytosolic calcium ion concentration (GO:0051481)2.39998028
197photoreceptor cell maintenance (GO:0045494)2.37297040
198pyrimidine-containing compound catabolic process (GO:0072529)2.36791933
199GPI anchor metabolic process (GO:0006505)2.36157365

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.99099807
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.46021344
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.91041398
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.63565557
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.55342114
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.21194544
7ZNF274_21170338_ChIP-Seq_K562_Hela4.03909986
8EZH2_22144423_ChIP-Seq_EOC_Human4.00295608
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.53433955
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.19985064
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.17304825
12VDR_22108803_ChIP-Seq_LS180_Human3.08031708
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.88284756
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.81846494
15* IRF8_27001747_Chip-Seq_BMDM_Mouse2.81730912
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.77645013
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.76424311
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.64309885
19* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.62124583
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.58922124
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.47880382
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.46853574
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.37098416
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.22326033
25MYB_26560356_Chip-Seq_TH2_Human2.21713773
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21538079
27IGF1R_20145208_ChIP-Seq_DFB_Human2.18044248
28* SPI1_23547873_ChIP-Seq_NB4_Human2.17453644
29MYC_22102868_ChIP-Seq_BL_Human2.14892194
30* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13210214
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10255702
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.08275184
33GBX2_23144817_ChIP-Seq_PC3_Human2.01071682
34* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.96794702
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96603238
36VDR_21846776_ChIP-Seq_THP-1_Human1.96355231
37RUNX_20019798_ChIP-Seq_JUKART_Human1.96147839
38MYB_26560356_Chip-Seq_TH1_Human1.93548192
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.93498401
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89074866
41MAF_26560356_Chip-Seq_TH1_Human1.87581496
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.87377161
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83149301
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82129217
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81561175
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79594857
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.79310627
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78331489
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77147223
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75505589
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.75252870
52TP53_22573176_ChIP-Seq_HFKS_Human1.74031360
53SCL_19346495_ChIP-Seq_HPC-7_Human1.72799143
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69221530
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.69128513
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.67136423
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66716688
58FUS_26573619_Chip-Seq_HEK293_Human1.66224661
59IRF1_19129219_ChIP-ChIP_H3396_Human1.64474669
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.62604420
61MYC_18940864_ChIP-ChIP_HL60_Human1.61967387
62* UTX_26944678_Chip-Seq_JUKART_Human1.61261573
63REST_21632747_ChIP-Seq_MESCs_Mouse1.58452573
64VDR_23849224_ChIP-Seq_CD4+_Human1.57007408
65EWS_26573619_Chip-Seq_HEK293_Human1.56102765
66* VDR_24763502_ChIP-Seq_THP-1_Human1.53480814
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52634156
68EED_16625203_ChIP-ChIP_MESCs_Mouse1.49842416
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49722757
70ELK1_19687146_ChIP-ChIP_HELA_Human1.49714075
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.49379286
72ER_23166858_ChIP-Seq_MCF-7_Human1.48609862
73RUNX1_22412390_ChIP-Seq_EML_Mouse1.48559001
74RNF2_27304074_Chip-Seq_NSC_Mouse1.48509202
75P300_19829295_ChIP-Seq_ESCs_Human1.48337401
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46171951
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.45651822
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.44883673
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44460589
80GATA3_21878914_ChIP-Seq_MCF-7_Human1.44240879
81* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43612257
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.42143884
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.41600653
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41600653
85AR_20517297_ChIP-Seq_VCAP_Human1.41473399
86GABP_17652178_ChIP-ChIP_JURKAT_Human1.41061640
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40902176
88KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.40878078
89JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40553671
90FOXP3_21729870_ChIP-Seq_TREG_Human1.33884463
91Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30375853
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30326881
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29806698
94BCAT_22108803_ChIP-Seq_LS180_Human1.29374692
95ETS1_20019798_ChIP-Seq_JURKAT_Human1.28684232
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28381494
97EZH2_27294783_Chip-Seq_ESCs_Mouse1.27994785
98CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27563575
99GATA3_27048872_Chip-Seq_THYMUS_Human1.26722406
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25246823
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25246823
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24551961
103MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24504123
104EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.24221261
105TAF15_26573619_Chip-Seq_HEK293_Human1.23687273
106CBP_20019798_ChIP-Seq_JUKART_Human1.22991325
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22991325
108NANOG_19829295_ChIP-Seq_ESCs_Human1.22608742
109SOX2_19829295_ChIP-Seq_ESCs_Human1.22608742
110REST_18959480_ChIP-ChIP_MESCs_Mouse1.22528956
111JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22279537
112TAF2_19829295_ChIP-Seq_ESCs_Human1.21490367
113SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21366386
114SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21260194
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20420491
116ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19746683
117NANOG_20526341_ChIP-Seq_ESCs_Human1.18128570
118* MAF_26560356_Chip-Seq_TH2_Human1.17504399
119ERA_21632823_ChIP-Seq_H3396_Human1.17295393
120KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17194695
121GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16823638
122SPI1_23127762_ChIP-Seq_K562_Human1.16614963
123PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16486628
124NCOR_22424771_ChIP-Seq_293T_Human1.16074622
125FOXH1_21741376_ChIP-Seq_EPCs_Human1.15153021
126* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14963010
127PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14768091
128RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.13723835
129STAT3_23295773_ChIP-Seq_U87_Human1.13522632
130CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13194504
131* PU_27001747_Chip-Seq_BMDM_Mouse1.09519815
132SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09244213
133CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08587364
134CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08490137
135POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07254290
136SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07214484
137LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06465288
138PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06447844
139CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06219585
140RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05851535
141TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05772029
142AR_25329375_ChIP-Seq_VCAP_Human1.05660379
143CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05126545
144CIITA_25753668_ChIP-Seq_RAJI_Human1.05107604
145* HOXB7_26014856_ChIP-Seq_BT474_Human1.04128441
146MYC_19829295_ChIP-Seq_ESCs_Human1.04120634
147AR_21572438_ChIP-Seq_LNCaP_Human1.03803194
148NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03134936
149FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03064517
150EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.01674188
151GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01656207
152STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01322340
153EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01268291
154SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00907584
155SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00745864
156TCF7_22412390_ChIP-Seq_EML_Mouse1.00518903
157PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00002417
158PIAS1_25552417_ChIP-Seq_VCAP_Human0.99509682
159GATA3_26560356_Chip-Seq_TH2_Human0.99218173
160CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98781175
161TCF4_22108803_ChIP-Seq_LS180_Human0.98252650
162MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97919709
163SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97699750
164TCF4_23295773_ChIP-Seq_U87_Human0.97619900
165OCT4_20526341_ChIP-Seq_ESCs_Human0.97525391
166MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97396194
167E2F1_21310950_ChIP-Seq_MCF-7_Human0.96470135
168SMAD4_21799915_ChIP-Seq_A2780_Human0.96401863
169PRDM14_20953172_ChIP-Seq_ESCs_Human0.95550274
170VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94305470
171FOXH1_21741376_ChIP-Seq_ESCs_Human0.93347389
172MYC_18555785_ChIP-Seq_MESCs_Mouse0.92953834
173SMAD_19615063_ChIP-ChIP_OVARY_Human0.92826769
174MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92139261
175PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90476968
176FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87784586
177PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87570589
178JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.86753310
179MYC_19079543_ChIP-ChIP_MESCs_Mouse0.86454956
180NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86158039
181NELFA_20434984_ChIP-Seq_ESCs_Mouse0.86042825
182PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85501360
183STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85235896
184CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83876441
185NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82308323
186CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80402228
187* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80342367
188PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79950123
189KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.79199085

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.49446251
2MP0009785_altered_susceptibility_to3.61532663
3MP0000685_abnormal_immune_system3.40494458
4MP0001800_abnormal_humoral_immune3.34053578
5MP0003136_yellow_coat_color3.29642530
6MP0001790_abnormal_immune_system3.24744744
7MP0005387_immune_system_phenotype3.24744744
8MP0005000_abnormal_immune_tolerance3.23190744
9MP0005671_abnormal_response_to3.19607513
10MP0002148_abnormal_hypersensitivity_rea3.18115906
11MP0002653_abnormal_ependyma_morphology3.13062171
12MP0003436_decreased_susceptibility_to3.08440147
13MP0002452_abnormal_antigen_presenting2.97998110
14MP0008877_abnormal_DNA_methylation2.90448424
15MP0002723_abnormal_immune_serum2.80190996
16MP0001819_abnormal_immune_cell2.68516572
17MP0002420_abnormal_adaptive_immunity2.68364543
18MP0005025_abnormal_response_to2.66741847
19MP0006082_CNS_inflammation2.49412488
20MP0000372_irregular_coat_pigmentation2.49064857
21MP0002419_abnormal_innate_immunity2.48752080
22MP0002876_abnormal_thyroid_physiology2.43442825
23MP0008057_abnormal_DNA_replication2.41763573
24MP0002398_abnormal_bone_marrow2.41082145
25MP0003763_abnormal_thymus_physiology2.39813192
26MP0002006_tumorigenesis2.36531049
27MP0005551_abnormal_eye_electrophysiolog2.33438132
28MP0001968_abnormal_touch/_nociception2.26597518
29MP0000716_abnormal_immune_system2.24794441
30MP0002102_abnormal_ear_morphology2.22262311
31MP0002166_altered_tumor_susceptibility2.20355958
32MP0005084_abnormal_gallbladder_morpholo2.18714065
33MP0004142_abnormal_muscle_tone2.18675301
34MP0004885_abnormal_endolymph2.15557130
35MP0003880_abnormal_central_pattern2.12383565
36MP0002638_abnormal_pupillary_reflex2.09796530
37MP0005645_abnormal_hypothalamus_physiol2.07628721
38MP0002405_respiratory_system_inflammati2.02694812
39MP0003303_peritoneal_inflammation2.02470778
40MP0000689_abnormal_spleen_morphology2.01611140
41MP0003011_delayed_dark_adaptation1.99803579
42MP0009379_abnormal_foot_pigmentation1.98877957
43MP0002722_abnormal_immune_system1.95460603
44MP0008872_abnormal_physiological_respon1.94955264
45MP0001853_heart_inflammation1.88969067
46MP0004947_skin_inflammation1.88220054
47MP0009333_abnormal_splenocyte_physiolog1.86733372
48MP0000703_abnormal_thymus_morphology1.84304906
49MP0002429_abnormal_blood_cell1.83398945
50MP0006072_abnormal_retinal_apoptosis1.82340918
51MP0010155_abnormal_intestine_physiology1.78071051
52MP0004510_myositis1.76497150
53MP0002272_abnormal_nervous_system1.75112375
54MP0006276_abnormal_autonomic_nervous1.74562628
55MP0005253_abnormal_eye_physiology1.74121607
56MP0001984_abnormal_olfaction1.73845606
57MP0002928_abnormal_bile_duct1.72358269
58MP0008875_abnormal_xenobiotic_pharmacok1.72304069
59MP0003724_increased_susceptibility_to1.70856588
60MP0002254_reproductive_system_inflammat1.70201502
61MP0003646_muscle_fatigue1.68904413
62MP0001529_abnormal_vocalization1.67428716
63MP0009745_abnormal_behavioral_response1.65459709
64MP0002277_abnormal_respiratory_mucosa1.62158585
65MP0001845_abnormal_inflammatory_respons1.61679617
66MP0005310_abnormal_salivary_gland1.61558482
67MP0003195_calcinosis1.60608429
68MP0002138_abnormal_hepatobiliary_system1.58263189
69MP0003122_maternal_imprinting1.56616477
70MP0002396_abnormal_hematopoietic_system1.55657357
71MP0002736_abnormal_nociception_after1.51905083
72MP0009278_abnormal_bone_marrow1.48113260
73MP0005423_abnormal_somatic_nervous1.47942278
74MP0009046_muscle_twitch1.47190591
75MP0001905_abnormal_dopamine_level1.44175470
76MP0002132_abnormal_respiratory_system1.43074990
77MP0003448_altered_tumor_morphology1.42466198
78MP0004147_increased_porphyrin_level1.41738310
79MP0004043_abnormal_pH_regulation1.40771452
80MP0005464_abnormal_platelet_physiology1.40118521
81MP0008995_early_reproductive_senescence1.39668157
82MP0002572_abnormal_emotion/affect_behav1.39424569
83MP0010094_abnormal_chromosome_stability1.36083142
84MP0000858_altered_metastatic_potential1.35908587
85MP0004808_abnormal_hematopoietic_stem1.32397327
86MP0002733_abnormal_thermal_nociception1.31130750
87MP0002735_abnormal_chemical_nociception1.30221578
88MP0001970_abnormal_pain_threshold1.29631014
89MP0005174_abnormal_tail_pigmentation1.27043153
90MP0009764_decreased_sensitivity_to1.26838785
91MP0002837_dystrophic_cardiac_calcinosis1.26220562
92MP0003077_abnormal_cell_cycle1.25265047
93MP0003787_abnormal_imprinting1.24370193
94MP0005646_abnormal_pituitary_gland1.23412446
95MP0001501_abnormal_sleep_pattern1.23136600
96MP0008058_abnormal_DNA_repair1.22763519
97MP0010386_abnormal_urinary_bladder1.22411746
98MP0001545_abnormal_hematopoietic_system1.22389098
99MP0005397_hematopoietic_system_phenotyp1.22389098
100MP0002557_abnormal_social/conspecific_i1.20621853
101MP0008469_abnormal_protein_level1.20144095
102MP0001986_abnormal_taste_sensitivity1.19365562
103MP0002063_abnormal_learning/memory/cond1.18358743
104MP0002938_white_spotting1.17939935
105MP0001873_stomach_inflammation1.17866374
106MP0001533_abnormal_skeleton_physiology1.17727210
107MP0003283_abnormal_digestive_organ1.17042283
108MP0000490_abnormal_crypts_of1.15928030
109MP0008007_abnormal_cellular_replicative1.15825148
110MP0002009_preneoplasia1.15719735
111MP0001485_abnormal_pinna_reflex1.14288124
112MP0001486_abnormal_startle_reflex1.14286319
113MP0004742_abnormal_vestibular_system1.13225240
114MP0000631_abnormal_neuroendocrine_gland1.13007040
115MP0003693_abnormal_embryo_hatching1.11336718
116MP0005075_abnormal_melanosome_morpholog1.11218572
117MP0002064_seizures1.08610967
118MP0005379_endocrine/exocrine_gland_phen1.08575634
119MP0002163_abnormal_gland_morphology1.08297773
120MP0002933_joint_inflammation1.08220547
121MP0002019_abnormal_tumor_incidence1.08048539
122MP0005195_abnormal_posterior_eye1.07487437
123MP0000778_abnormal_nervous_system1.07288516
124MP0004133_heterotaxia1.06447886
125MP0000026_abnormal_inner_ear1.06140194
126MP0001919_abnormal_reproductive_system1.05849640
127MP0005171_absent_coat_pigmentation1.05746857
128MP0003121_genomic_imprinting1.05089304
129MP0001502_abnormal_circadian_rhythm1.04159319
130MP0000015_abnormal_ear_pigmentation1.03937678
131MP0002067_abnormal_sensory_capabilities1.02785089
132MP0002734_abnormal_mechanical_nocicepti1.02767344
133MP0003635_abnormal_synaptic_transmissio1.02383824
134MP0003111_abnormal_nucleus_morphology1.02199478
135MP0005389_reproductive_system_phenotype1.00136493
136MP0006292_abnormal_olfactory_placode0.97469846
137MP0004381_abnormal_hair_follicle0.96302142
138MP0002752_abnormal_somatic_nervous0.95712070
139MP0004924_abnormal_behavior0.94144724
140MP0005386_behavior/neurological_phenoty0.94144724
141MP0005167_abnormal_blood-brain_barrier0.93969253
142MP0004145_abnormal_muscle_electrophysio0.93178109
143MP0001963_abnormal_hearing_physiology0.92888322
144MP0002160_abnormal_reproductive_system0.91036838
145MP0002909_abnormal_adrenal_gland0.89944624
146MP0002998_abnormal_bone_remodeling0.89890188
147MP0003252_abnormal_bile_duct0.89058632
148MP0010352_gastrointestinal_tract_polyps0.87651595
149MP0002751_abnormal_autonomic_nervous0.87094134
150MP0003828_pulmonary_edema0.85800326
151MP0008789_abnormal_olfactory_epithelium0.85416611
152MP0004957_abnormal_blastocyst_morpholog0.85113472
153MP0002095_abnormal_skin_pigmentation0.85054123
154MP0000049_abnormal_middle_ear0.79647087
155MP0000313_abnormal_cell_death0.78729671
156MP0005076_abnormal_cell_differentiation0.78336259
157MP0005391_vision/eye_phenotype0.77972632
158MP0000569_abnormal_digit_pigmentation0.77773803
159MP0001764_abnormal_homeostasis0.77126016
160MP0000427_abnormal_hair_cycle0.76809341
161MP0003878_abnormal_ear_physiology0.74582595
162MP0005377_hearing/vestibular/ear_phenot0.74582595
163MP0001348_abnormal_lacrimal_gland0.74258973
164MP0001324_abnormal_eye_pigmentation0.73393743
165MP0006035_abnormal_mitochondrial_morpho0.72309622
166MP0003453_abnormal_keratinocyte_physiol0.71850949
167MP0009697_abnormal_copulation0.71160972
168MP0000230_abnormal_systemic_arterial0.70857677
169MP0003137_abnormal_impulse_conducting0.70769599
170MP0002882_abnormal_neuron_morphology0.70740246
171MP0000350_abnormal_cell_proliferation0.66086558
172MP0003866_abnormal_defecation0.66049833
173MP0003186_abnormal_redox_activity0.65502129
174MP0003172_abnormal_lysosome_physiology0.62682297
175MP0009763_increased_sensitivity_to0.61728407
176MP0005058_abnormal_lysosome_morphology0.60985766
177MP0000249_abnormal_blood_vessel0.59230981
178MP0010307_abnormal_tumor_latency0.58453266
179MP0000465_gastrointestinal_hemorrhage0.58282859
180MP0005390_skeleton_phenotype0.57601796
181MP0001879_abnormal_lymphatic_vessel0.57091351
182MP0000371_diluted_coat_color0.53656846
183MP0009765_abnormal_xenobiotic_induced0.53378463
184MP0003300_gastrointestinal_ulcer0.53212271
185MP0001186_pigmentation_phenotype0.52707338
186MP0003786_premature_aging0.52565292
187MP0002136_abnormal_kidney_physiology0.51127598
188MP0002075_abnormal_coat/hair_pigmentati0.50092271
189MP0003890_abnormal_embryonic-extraembry0.49834121
190MP0002332_abnormal_exercise_endurance0.49561990

Predicted human phenotypes

RankGene SetZ-score
1Recurrent viral infections (HP:0004429)5.23415268
2Congenital stationary night blindness (HP:0007642)4.82565823
3B lymphocytopenia (HP:0010976)4.82013943
4Abnormality of B cell number (HP:0010975)4.82013943
5Recurrent abscess formation (HP:0002722)4.73112631
6Agammaglobulinemia (HP:0004432)4.69379184
7Abnormality of T cell number (HP:0011839)4.67977322
8Thyroiditis (HP:0100646)4.65360795
9T lymphocytopenia (HP:0005403)4.59481124
10Panhypogammaglobulinemia (HP:0003139)4.53390087
11Eosinophilia (HP:0001880)4.48871754
12Recurrent fungal infections (HP:0002841)4.34579480
13Combined immunodeficiency (HP:0005387)4.27686094
14Severe combined immunodeficiency (HP:0004430)4.26462632
15Recurrent bacterial skin infections (HP:0005406)4.25639021
16Pancreatic cysts (HP:0001737)4.25168352
17True hermaphroditism (HP:0010459)4.07133785
18Elevated erythrocyte sedimentation rate (HP:0003565)4.04646130
19Granulocytopenia (HP:0001913)4.03117583
20Pancreatic fibrosis (HP:0100732)3.98980565
21Eczematoid dermatitis (HP:0000976)3.96644143
22Cellulitis (HP:0100658)3.95833664
23Abnormality of midbrain morphology (HP:0002418)3.91495720
24Molar tooth sign on MRI (HP:0002419)3.91495720
25Mediastinal lymphadenopathy (HP:0100721)3.88034299
26Meningitis (HP:0001287)3.84927623
27Abnormal respiratory epithelium morphology (HP:0012253)3.73665519
28Abnormal respiratory motile cilium morphology (HP:0005938)3.73665519
29Abnormality of eosinophils (HP:0001879)3.67440347
30Increased IgM level (HP:0003496)3.62386623
31Medial flaring of the eyebrow (HP:0010747)3.55771790
32Leukocytosis (HP:0001974)3.55450536
33IgG deficiency (HP:0004315)3.38851692
34Recurrent bronchitis (HP:0002837)3.37175512
35Vasculitis (HP:0002633)3.28216438
36Abnormality of T cells (HP:0002843)3.23027688
37Retrobulbar optic neuritis (HP:0100654)3.22266460
38Optic neuritis (HP:0100653)3.22266460
39Myositis (HP:0100614)3.20441608
40Abnormal delayed hypersensitivity skin test (HP:0002963)3.16207270
41Absent/shortened dynein arms (HP:0200106)3.15197308
42Dynein arm defect of respiratory motile cilia (HP:0012255)3.15197308
43Stomatitis (HP:0010280)3.12146872
44Papilloma (HP:0012740)3.11844330
45Verrucae (HP:0200043)3.11844330
46Hypoplasia of the thymus (HP:0000778)3.11141142
47Gait imbalance (HP:0002141)3.08333109
48Abnormal ciliary motility (HP:0012262)3.04649716
49Orchitis (HP:0100796)3.04388267
50Recurrent skin infections (HP:0001581)3.02537115
51Chronic mucocutaneous candidiasis (HP:0002728)3.01546322
52Recurrent cutaneous fungal infections (HP:0011370)3.01546322
53Autoimmune thrombocytopenia (HP:0001973)2.98065701
54Congenital primary aphakia (HP:0007707)2.95876627
55Nephronophthisis (HP:0000090)2.95178791
56Abnormality of macrophages (HP:0004311)2.93362670
57Chromosomal breakage induced by crosslinking agents (HP:0003221)2.88702161
58Recurrent pneumonia (HP:0006532)2.87477703
59Acute necrotizing encephalopathy (HP:0006965)2.87205164
60Recurrent gram-negative bacterial infections (HP:0005420)2.82629301
61Duplicated collecting system (HP:0000081)2.81125247
62IgM deficiency (HP:0002850)2.79795950
63Colitis (HP:0002583)2.78427109
64Nephrogenic diabetes insipidus (HP:0009806)2.74606731
65Abnormality of the renal cortex (HP:0011035)2.74331948
66Chronic obstructive pulmonary disease (HP:0006510)2.73071457
67Obstructive lung disease (HP:0006536)2.73071457
68Abnormal respiratory motile cilium physiology (HP:0012261)2.72747600
69Cystic liver disease (HP:0006706)2.70805010
70Abnormality of the renal collecting system (HP:0004742)2.67087150
71Stomach cancer (HP:0012126)2.66873066
72Small epiphyses (HP:0010585)2.65756623
73Chronic sinusitis (HP:0011109)2.64952174
74Mitochondrial inheritance (HP:0001427)2.64877682
75Chromsome breakage (HP:0040012)2.64341165
76Osteomyelitis (HP:0002754)2.63592812
77Chronic otitis media (HP:0000389)2.62957234
78Inflammation of the large intestine (HP:0002037)2.61454717
79Sepsis (HP:0100806)2.59696783
803-Methylglutaconic aciduria (HP:0003535)2.56510681
81Concave nail (HP:0001598)2.55925929
82Recurrent lower respiratory tract infections (HP:0002783)2.54610265
83Gingivitis (HP:0000230)2.53512852
84Abnormality of the renal medulla (HP:0100957)2.52305337
85Recurrent sinusitis (HP:0011108)2.52154941
86Gastrointestinal inflammation (HP:0004386)2.51699943
87Pulmonary infiltrates (HP:0002113)2.50155181
88Attenuation of retinal blood vessels (HP:0007843)2.48527730
89Abnormal mitochondria in muscle tissue (HP:0008316)2.48271592
90Sclerocornea (HP:0000647)2.47882064
91Hypoproteinemia (HP:0003075)2.46746437
92Reticulocytopenia (HP:0001896)2.45920903
93Acute encephalopathy (HP:0006846)2.44474167
94Type II lissencephaly (HP:0007260)2.42986485
95Increased CSF lactate (HP:0002490)2.42879822
96Acute lymphatic leukemia (HP:0006721)2.42740942
97Encephalitis (HP:0002383)2.41542266
98Abnormal rod and cone electroretinograms (HP:0008323)2.39199166
99Abnormality of alanine metabolism (HP:0010916)2.38683026
100Hyperalaninemia (HP:0003348)2.38683026
101Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.38683026
102Abnormality of cells of the lymphoid lineage (HP:0012140)2.38094673
103Progressive macrocephaly (HP:0004481)2.36374923
104Lymphoma (HP:0002665)2.36058022
105Lymphopenia (HP:0001888)2.34373130
106Decreased electroretinogram (ERG) amplitude (HP:0000654)2.32198111
107Optic disc pallor (HP:0000543)2.30951286
108Chronic hepatic failure (HP:0100626)2.29637669
109Abnormality of T cell physiology (HP:0011840)2.27680528
110Hyperventilation (HP:0002883)2.26431508
111Pendular nystagmus (HP:0012043)2.23702781
112Abolished electroretinogram (ERG) (HP:0000550)2.23136791
113Periodontitis (HP:0000704)2.22787776
114Genital tract atresia (HP:0001827)2.22326457
115Vaginal atresia (HP:0000148)2.21841892
116Abnormal drinking behavior (HP:0030082)2.21048716
117Polydipsia (HP:0001959)2.21048716
118Pustule (HP:0200039)2.18662166
119Increased corneal curvature (HP:0100692)2.17656532
120Keratoconus (HP:0000563)2.17656532
121Clubbing of toes (HP:0100760)2.17523439
122Abnormality of the intervertebral disk (HP:0005108)2.15927406
123Hypergammaglobulinemia (HP:0010702)2.15547774
124Neutropenia (HP:0001875)2.14956606
125Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14076370
126Decreased central vision (HP:0007663)2.14023274
127Anencephaly (HP:0002323)2.13634958
128Renal cortical cysts (HP:0000803)2.13141036
129Postaxial foot polydactyly (HP:0001830)2.11769050
130Furrowed tongue (HP:0000221)2.10815829
131Hepatocellular necrosis (HP:0001404)2.09694569
132Keratoconjunctivitis sicca (HP:0001097)2.08240216
133Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.08156869
134Basal ganglia calcification (HP:0002135)2.07947003
135Polyphagia (HP:0002591)2.07807188
136Nasal polyposis (HP:0100582)2.07174783
137IgA deficiency (HP:0002720)2.06937280
138Gastrointestinal stroma tumor (HP:0100723)2.05864465
139Prostate neoplasm (HP:0100787)2.04726094
140Abnormal number of erythroid precursors (HP:0012131)2.02998496
141Abnormality of the fingertips (HP:0001211)2.02962191
142Poor coordination (HP:0002370)2.02134536
143Leukopenia (HP:0001882)1.99895355
144Tubular atrophy (HP:0000092)1.99513826
145Congenital, generalized hypertrichosis (HP:0004540)1.98881508
146Large for gestational age (HP:0001520)1.97187571
147Skin ulcer (HP:0200042)1.96884776
148Postaxial hand polydactyly (HP:0001162)1.96871184
149Hepatic necrosis (HP:0002605)1.95690437
150Abnormality of cells of the erythroid lineage (HP:0012130)1.94897933
151Inability to walk (HP:0002540)1.94639470
152Aplasia/Hypoplasia of the thymus (HP:0010515)1.93189704
153Aplasia/Hypoplasia of the tongue (HP:0010295)1.93080462
154Congenital hepatic fibrosis (HP:0002612)1.92707621
155Mesangial abnormality (HP:0001966)1.92405068
156Aplasia/Hypoplasia of the uvula (HP:0010293)1.91814732
157Aplasia/Hypoplasia of the tibia (HP:0005772)1.91233233
158Keratoconjunctivitis (HP:0001096)1.91176088
159Gastrointestinal infarctions (HP:0005244)1.91075889
160Colon cancer (HP:0003003)1.89372339
161Type 2 muscle fiber atrophy (HP:0003554)1.89356294
162Male pseudohermaphroditism (HP:0000037)1.88763479
163Hypochromic anemia (HP:0001931)1.88738804
164Aplasia/Hypoplasia of the spleen (HP:0010451)1.87910827
165Polyuria (HP:0000103)1.85583488
166Lissencephaly (HP:0001339)1.85158723
167Birth length less than 3rd percentile (HP:0003561)1.84144019
168Erythroderma (HP:0001019)1.83948953
169Autoimmune hemolytic anemia (HP:0001890)1.83076849
170Bronchitis (HP:0012387)1.82389564
171Hemoptysis (HP:0002105)1.82272871
172Cheilitis (HP:0100825)1.80076403
173Asplenia (HP:0001746)1.79751530
174Agitation (HP:0000713)1.78981198
175Rhinitis (HP:0012384)1.78790896
176Urticaria (HP:0001025)1.78276625
177Abnormality of the prostate (HP:0008775)1.77775012
178Short tibia (HP:0005736)1.77324462
179Febrile seizures (HP:0002373)1.77055296
180Oligodactyly (hands) (HP:0001180)1.76836755
181Abnormality of the pons (HP:0007361)1.75436336
182Bronchiectasis (HP:0002110)1.74754723
183Skin rash (HP:0000988)1.74287340
184Hypothermia (HP:0002045)1.74204027
185Petechiae (HP:0000967)1.72073336
186Microretrognathia (HP:0000308)1.71405892
187Thrombocytosis (HP:0001894)1.70518518
188Retinitis pigmentosa (HP:0000510)1.68869632
189Hemiparesis (HP:0001269)1.68712360
190Patellar aplasia (HP:0006443)1.68095107
191Broad-based gait (HP:0002136)1.67747125
192Focal motor seizures (HP:0011153)1.67315210

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K103.89148887
2MAP3K143.84105200
3PINK13.72952478
4MAP4K13.12666703
5IRAK32.94456581
6IRAK42.92112109
7GRK62.88188739
8BLK2.78675499
9WNK42.75793886
10FRK2.71475222
11MAPK152.68158313
12TAOK32.66832104
13IKBKB2.57920251
14TYK22.56095048
15TLK12.54144687
16TXK2.52945594
17RIPK42.40721709
18DAPK22.24816835
19MAP4K22.22004505
20TSSK62.21842616
21JAK32.18771824
22CASK2.16461889
23BCKDK2.12900542
24TBK12.11482848
25IKBKE2.01039901
26CDK121.98831577
27MAPK131.94514696
28WNK31.88793676
29STK41.87650550
30INSRR1.87182952
31CAMKK21.85710791
32SYK1.84376984
33ZAK1.81940829
34MAPKAPK31.73443356
35CSF1R1.71045323
36PIM11.64156527
37STK101.61034047
38MAP3K131.56922746
39CHUK1.55184762
40PNCK1.54314185
41DYRK21.48810902
42TIE11.48094583
43MST41.45042809
44MAP3K111.42712757
45CSK1.34444854
46MAP2K71.34080555
47CLK11.32562345
48EIF2AK31.30521850
49BTK1.30216149
50MAP3K41.29716517
51JAK11.27180779
52NME21.24532244
53EIF2AK21.23620668
54ZAP701.21667934
55NLK1.21623582
56ADRBK21.19110192
57LYN1.18579143
58VRK21.16256039
59LCK1.16165216
60HCK1.15369243
61VRK11.12862777
62CAMKK11.12388275
63PBK1.11771202
64BCR1.11725488
65ERN11.11578671
66RPS6KA41.10332965
67NTRK21.07666407
68CDK191.04392685
69IRAK11.03127526
70OXSR11.02310637
71PASK1.01786373
72MAPKAPK51.01721946
73ADRBK11.01265249
74TRIM281.01144431
75STK391.00739300
76ITK0.98425795
77PRKCG0.98053069
78YES10.97911104
79KIT0.96818796
80TEC0.95048073
81PIM20.94068528
82MAPK70.93421053
83PLK40.88218323
84NUAK10.88180853
85FGFR30.87753440
86BMPR20.87752234
87EPHA30.86870148
88WEE10.86382863
89NME10.84966463
90FES0.83974125
91SIK20.83567784
92CSNK1G10.82901528
93MAP2K60.82683461
94PKN10.80362655
95GRK10.78440584
96TGFBR10.78184436
97CDK40.77893721
98CAMK10.77788365
99DYRK30.75905371
100RPS6KA50.75057512
101SRPK10.74812922
102PHKG10.73423288
103PHKG20.73423288
104IRAK20.72344093
105EPHB20.69993586
106PAK30.69088947
107MARK30.68771347
108NEK90.68636826
109MARK10.68254416
110SIK30.67354073
111PRKCQ0.66366006
112HIPK20.66292161
113ATR0.64151064
114PRKCD0.64092272
115CSNK1G30.63865295
116CSNK1G20.63493691
117BUB10.63263391
118PRKCE0.61435119
119MAP2K40.61029646
120ABL20.58347493
121NEK20.58239961
122BRSK20.57966407
123MAP3K120.56147257
124MATK0.54851040
125CDK90.51975000
126LIMK10.51974162
127PIK3CA0.51774785
128PRKCI0.51702302
129PRKACA0.51036014
130BMPR1B0.50952624
131GRK70.50343083
132FGFR40.48698124
133JAK20.48325392
134CAMK2A0.45591244
135MAPK40.44760769
136STK160.43368676
137FGR0.42300153
138SGK4940.42039191
139SGK2230.42039191
140TGFBR20.41985678
141CSNK1A1L0.41929858
142CSNK1A10.41782262
143ABL10.41291195
144CDK30.40501199
145MAPKAPK20.40386765
146MAP3K80.40369694
147CHEK20.39696059
148MELK0.39273627
149LRRK20.38924274
150DYRK1A0.38874314
151DYRK1B0.38302614
152MKNK20.38264282
153CHEK10.38153611
154BRD40.37045743
155STK110.36500471
156FLT30.36466819
157OBSCN0.36250412
158PRKCA0.35528859
159KDR0.35483781
160ACVR1B0.34845380
161PTK2B0.34119164
162NTRK30.33167343
163AURKB0.33155440
164PRKCH0.32974672
165CAMK40.32880745
166TESK20.31732134
167SGK20.31656854
168MAPK120.31066208
169PLK10.30030800
170RPS6KB20.29918723
171PRKCZ0.29820057
172EIF2AK10.29362190
173STK38L0.28393106

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.54544621
2Oxidative phosphorylation_Homo sapiens_hsa001903.44373202
3NF-kappa B signaling pathway_Homo sapiens_hsa040643.14674506
4Graft-versus-host disease_Homo sapiens_hsa053323.02640175
5Parkinsons disease_Homo sapiens_hsa050122.85048582
6Allograft rejection_Homo sapiens_hsa053302.69965724
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.61634304
8Phototransduction_Homo sapiens_hsa047442.58541650
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.57644316
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.55027706
11Nitrogen metabolism_Homo sapiens_hsa009102.49662329
12Nicotine addiction_Homo sapiens_hsa050332.47662613
13Caffeine metabolism_Homo sapiens_hsa002322.44894864
14Leishmaniasis_Homo sapiens_hsa051402.39424095
15Linoleic acid metabolism_Homo sapiens_hsa005912.32515119
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.32487998
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.30769051
18Measles_Homo sapiens_hsa051622.12977123
19B cell receptor signaling pathway_Homo sapiens_hsa046622.10011737
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.09269341
21NOD-like receptor signaling pathway_Homo sapiens_hsa046212.06429593
22Toll-like receptor signaling pathway_Homo sapiens_hsa046202.03530334
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.00713308
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.94233085
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.93301194
26Non-homologous end-joining_Homo sapiens_hsa034501.90817199
27Protein export_Homo sapiens_hsa030601.89431894
28Huntingtons disease_Homo sapiens_hsa050161.88260915
29Cardiac muscle contraction_Homo sapiens_hsa042601.88008600
30Ribosome_Homo sapiens_hsa030101.85504240
31Osteoclast differentiation_Homo sapiens_hsa043801.81634031
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81262324
33Hematopoietic cell lineage_Homo sapiens_hsa046401.78983117
34Herpes simplex infection_Homo sapiens_hsa051681.78319604
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.77638697
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72667891
37Alzheimers disease_Homo sapiens_hsa050101.72551320
38Ether lipid metabolism_Homo sapiens_hsa005651.68694007
39Type I diabetes mellitus_Homo sapiens_hsa049401.66635147
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.65736635
41Legionellosis_Homo sapiens_hsa051341.64432550
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58812290
43DNA replication_Homo sapiens_hsa030301.58640186
44Systemic lupus erythematosus_Homo sapiens_hsa053221.58297152
45Antigen processing and presentation_Homo sapiens_hsa046121.57001050
46Butanoate metabolism_Homo sapiens_hsa006501.48506903
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47708853
48Autoimmune thyroid disease_Homo sapiens_hsa053201.45929835
49TNF signaling pathway_Homo sapiens_hsa046681.45889679
50Influenza A_Homo sapiens_hsa051641.44726038
51Tuberculosis_Homo sapiens_hsa051521.42220012
52T cell receptor signaling pathway_Homo sapiens_hsa046601.41629021
53Pertussis_Homo sapiens_hsa051331.41296213
54Base excision repair_Homo sapiens_hsa034101.36898870
55Asthma_Homo sapiens_hsa053101.35714034
56Mismatch repair_Homo sapiens_hsa034301.34088917
57Apoptosis_Homo sapiens_hsa042101.33867460
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31934205
59Malaria_Homo sapiens_hsa051441.31298802
60Morphine addiction_Homo sapiens_hsa050321.30008518
61Peroxisome_Homo sapiens_hsa041461.29983285
62Fanconi anemia pathway_Homo sapiens_hsa034601.28167388
63Olfactory transduction_Homo sapiens_hsa047401.27869591
64Homologous recombination_Homo sapiens_hsa034401.26921351
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25218587
66Rheumatoid arthritis_Homo sapiens_hsa053231.25056733
67Epstein-Barr virus infection_Homo sapiens_hsa051691.24428928
68Selenocompound metabolism_Homo sapiens_hsa004501.23336227
69Regulation of autophagy_Homo sapiens_hsa041401.22943850
70Steroid biosynthesis_Homo sapiens_hsa001001.21789364
71Jak-STAT signaling pathway_Homo sapiens_hsa046301.21441586
72Chemokine signaling pathway_Homo sapiens_hsa040621.20356860
73Toxoplasmosis_Homo sapiens_hsa051451.19473323
74Collecting duct acid secretion_Homo sapiens_hsa049661.15892350
75Tryptophan metabolism_Homo sapiens_hsa003801.15475749
76African trypanosomiasis_Homo sapiens_hsa051431.14479591
77Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10338659
78GABAergic synapse_Homo sapiens_hsa047271.10012744
79Taste transduction_Homo sapiens_hsa047421.08899802
80Spliceosome_Homo sapiens_hsa030401.06626326
81Viral carcinogenesis_Homo sapiens_hsa052031.06183322
82Chemical carcinogenesis_Homo sapiens_hsa052041.05320760
83Hepatitis B_Homo sapiens_hsa051611.04205725
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04067597
85Proteasome_Homo sapiens_hsa030501.03772328
86RNA polymerase_Homo sapiens_hsa030200.98570591
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98440954
88Staphylococcus aureus infection_Homo sapiens_hsa051500.96917584
89Shigellosis_Homo sapiens_hsa051310.96842223
90p53 signaling pathway_Homo sapiens_hsa041150.95545118
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.94526705
92ABC transporters_Homo sapiens_hsa020100.93759096
93Salmonella infection_Homo sapiens_hsa051320.93734617
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92062200
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.88556326
96Insulin secretion_Homo sapiens_hsa049110.88553417
97Sulfur relay system_Homo sapiens_hsa041220.87563937
98Acute myeloid leukemia_Homo sapiens_hsa052210.82820777
99Purine metabolism_Homo sapiens_hsa002300.80859479
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80771668
101Hepatitis C_Homo sapiens_hsa051600.80750262
102Retinol metabolism_Homo sapiens_hsa008300.80646912
103Pyrimidine metabolism_Homo sapiens_hsa002400.80352065
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79814630
105Viral myocarditis_Homo sapiens_hsa054160.77905187
106Fatty acid biosynthesis_Homo sapiens_hsa000610.74894630
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.73807219
108Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73289833
109Small cell lung cancer_Homo sapiens_hsa052220.72489706
110HTLV-I infection_Homo sapiens_hsa051660.71773475
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70168021
112Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70077035
113Other glycan degradation_Homo sapiens_hsa005110.69327200
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67856343
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67391710
116Nucleotide excision repair_Homo sapiens_hsa034200.67324121
117Cell cycle_Homo sapiens_hsa041100.66898781
118Serotonergic synapse_Homo sapiens_hsa047260.66126107
119Metabolic pathways_Homo sapiens_hsa011000.65205551
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64703025
121Glutamatergic synapse_Homo sapiens_hsa047240.64451934
122Propanoate metabolism_Homo sapiens_hsa006400.63996430
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63719790
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63436865
125Ovarian steroidogenesis_Homo sapiens_hsa049130.63023694
126Chronic myeloid leukemia_Homo sapiens_hsa052200.60578915
127RNA degradation_Homo sapiens_hsa030180.59301197
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58823272
129Circadian entrainment_Homo sapiens_hsa047130.58275876
130Calcium signaling pathway_Homo sapiens_hsa040200.56555467
131Basal transcription factors_Homo sapiens_hsa030220.56044340
132Salivary secretion_Homo sapiens_hsa049700.51504327
133Pancreatic cancer_Homo sapiens_hsa052120.50214403
134SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49816307
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48769967
136Cocaine addiction_Homo sapiens_hsa050300.48199487
137Fat digestion and absorption_Homo sapiens_hsa049750.47539386
138MicroRNAs in cancer_Homo sapiens_hsa052060.47074100
139Mineral absorption_Homo sapiens_hsa049780.45958231
140Phagosome_Homo sapiens_hsa041450.45556673
141RNA transport_Homo sapiens_hsa030130.45395149
142Alcoholism_Homo sapiens_hsa050340.44993195
143Basal cell carcinoma_Homo sapiens_hsa052170.44453358
144One carbon pool by folate_Homo sapiens_hsa006700.44211040
145Amphetamine addiction_Homo sapiens_hsa050310.43317037
146Synaptic vesicle cycle_Homo sapiens_hsa047210.41843030
147Glycerolipid metabolism_Homo sapiens_hsa005610.40927642
148Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39685230
149FoxO signaling pathway_Homo sapiens_hsa040680.36609444
150Notch signaling pathway_Homo sapiens_hsa043300.35160620
151Dopaminergic synapse_Homo sapiens_hsa047280.35066755
152Platelet activation_Homo sapiens_hsa046110.34943675
153Drug metabolism - other enzymes_Homo sapiens_hsa009830.34027453
154Prostate cancer_Homo sapiens_hsa052150.33661262
155Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33238673
156mRNA surveillance pathway_Homo sapiens_hsa030150.31682453
157Cholinergic synapse_Homo sapiens_hsa047250.31656645
158Cysteine and methionine metabolism_Homo sapiens_hsa002700.29040463
159cAMP signaling pathway_Homo sapiens_hsa040240.28849746
160Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28369492
161Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27751975
162Non-small cell lung cancer_Homo sapiens_hsa052230.27059467
163Lysosome_Homo sapiens_hsa041420.26503842
164Prolactin signaling pathway_Homo sapiens_hsa049170.26345851
165Neurotrophin signaling pathway_Homo sapiens_hsa047220.25911117
166Pathways in cancer_Homo sapiens_hsa052000.24389143
167Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24345834
168MAPK signaling pathway_Homo sapiens_hsa040100.21023530
169Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20173343
170Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19906063
171Arachidonic acid metabolism_Homo sapiens_hsa005900.19594321

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