ARL6IP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the ARL6ip family and encodes a transmembrane protein that is predominantly localized to intracytoplasmic membranes. It is highly expressed in early myeloid progenitor cells and thought to be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Mutations in this gene are associated with spastic paraplegia 61 (SPG61). Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.50969873
2metaphase plate congression (GO:0051310)5.45805506
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.40905143
4regulation of mitotic spindle organization (GO:0060236)5.14606830
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.97343203
6ATP synthesis coupled proton transport (GO:0015986)4.97343203
7regulation of spindle organization (GO:0090224)4.90963991
8fatty acid elongation (GO:0030497)4.71245610
9protein localization to kinetochore (GO:0034501)4.66698890
10neuron cell-cell adhesion (GO:0007158)4.62504176
11central nervous system myelination (GO:0022010)4.59824585
12axon ensheathment in central nervous system (GO:0032291)4.59824585
13chaperone-mediated protein transport (GO:0072321)4.31609715
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.28731957
15protein localization to chromosome, centromeric region (GO:0071459)4.22266693
16DNA topological change (GO:0006265)4.19545185
17synaptic vesicle exocytosis (GO:0016079)4.16632512
18spindle checkpoint (GO:0031577)4.12804119
19chromatin remodeling at centromere (GO:0031055)4.05442115
20dopamine transport (GO:0015872)3.99806290
21protein neddylation (GO:0045116)3.96887360
22mitotic sister chromatid segregation (GO:0000070)3.96389004
23establishment of protein localization to mitochondrial membrane (GO:0090151)3.95630383
24negative regulation of neurotransmitter transport (GO:0051589)3.85475176
25respiratory electron transport chain (GO:0022904)3.77177012
26mitotic spindle checkpoint (GO:0071174)3.76660808
27regulation of chromosome segregation (GO:0051983)3.74027650
28electron transport chain (GO:0022900)3.69055408
29mitotic chromosome condensation (GO:0007076)3.67637318
30ATP hydrolysis coupled proton transport (GO:0015991)3.64454176
31energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.64454176
32long-chain fatty acid biosynthetic process (GO:0042759)3.63125794
33gamma-aminobutyric acid signaling pathway (GO:0007214)3.61558426
34DNA double-strand break processing (GO:0000729)3.61553413
35resolution of meiotic recombination intermediates (GO:0000712)3.59884993
36mitotic spindle assembly checkpoint (GO:0007094)3.56550809
37neurotransmitter uptake (GO:0001504)3.55985439
38negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.55338083
39negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.55338083
40negative regulation of mitotic sister chromatid segregation (GO:0033048)3.55338083
41negative regulation of mitotic sister chromatid separation (GO:2000816)3.55338083
42negative regulation of sister chromatid segregation (GO:0033046)3.55338083
43spindle assembly checkpoint (GO:0071173)3.53459782
44negative regulation of chromosome segregation (GO:0051985)3.52730626
45histone exchange (GO:0043486)3.48816272
46dopamine biosynthetic process (GO:0042416)3.45377491
47protein localization to chromosome (GO:0034502)3.40566106
48sister chromatid segregation (GO:0000819)3.39979172
49regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.39961016
50establishment of integrated proviral latency (GO:0075713)3.38046829
51regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.32239224
52regulation of mitotic metaphase/anaphase transition (GO:0030071)3.32239224
53negative regulation of microtubule polymerization (GO:0031115)3.31558932
54NADH dehydrogenase complex assembly (GO:0010257)3.30989588
55mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.30989588
56mitochondrial respiratory chain complex I assembly (GO:0032981)3.30989588
57regulation of mitotic sister chromatid separation (GO:0010965)3.29798601
58regulation of mitotic sister chromatid segregation (GO:0033047)3.29798601
59regulation of sister chromatid segregation (GO:0033045)3.29798601
60regulation of dopamine metabolic process (GO:0042053)3.28597693
61regulation of catecholamine metabolic process (GO:0042069)3.28597693
62meiotic chromosome segregation (GO:0045132)3.27584252
63chromosome segregation (GO:0007059)3.25790884
64attachment of spindle microtubules to kinetochore (GO:0008608)3.22764338
65mitotic spindle organization (GO:0007052)3.21580128
66substantia nigra development (GO:0021762)3.20193127
67protein localization to synapse (GO:0035418)3.19796889
68mating behavior (GO:0007617)3.19307636
69transferrin transport (GO:0033572)3.15164507
70DNA replication-independent nucleosome organization (GO:0034724)3.13986699
71DNA replication-independent nucleosome assembly (GO:0006336)3.13986699
72pyrimidine nucleobase catabolic process (GO:0006208)3.13209295
73microtubule polymerization or depolymerization (GO:0031109)3.12499981
74presynaptic membrane organization (GO:0097090)3.11942499
75presynaptic membrane assembly (GO:0097105)3.09437911
76kinetochore organization (GO:0051383)3.08054192
77glutamate receptor signaling pathway (GO:0007215)3.07471981
78response to histamine (GO:0034776)3.07196896
79glutamate secretion (GO:0014047)3.04697174
80synaptic transmission, dopaminergic (GO:0001963)3.03541893
81ventricular cardiac muscle cell development (GO:0055015)3.03416219
82G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.99938493
83negative regulation of mitosis (GO:0045839)2.94354731
84protein K6-linked ubiquitination (GO:0085020)2.93897995
85protein complex biogenesis (GO:0070271)2.93794653
86microtubule depolymerization (GO:0007019)2.93621103
87neuron recognition (GO:0008038)2.92292094
88vocalization behavior (GO:0071625)2.92134263
89catecholamine transport (GO:0051937)2.90910672
90establishment of viral latency (GO:0019043)2.90721634
91protein localization to cilium (GO:0061512)2.87081926
92neuron-neuron synaptic transmission (GO:0007270)2.85724775
93DNA ligation (GO:0006266)2.84963639
94positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.84662827
95positive regulation of chromosome segregation (GO:0051984)2.84140609
96trivalent inorganic cation transport (GO:0072512)2.83927132
97ferric iron transport (GO:0015682)2.83927132
98transmission of nerve impulse (GO:0019226)2.83782687
99regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.83272280
100limb bud formation (GO:0060174)2.83071334
101ionotropic glutamate receptor signaling pathway (GO:0035235)2.78631686
102regulation of synaptic vesicle exocytosis (GO:2000300)2.78588904
103negative regulation of synaptic transmission, GABAergic (GO:0032229)2.78357202
104mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.78072564
105mitotic cytokinesis (GO:0000281)2.76809222
106neuronal action potential propagation (GO:0019227)2.76060356
107hydrogen ion transmembrane transport (GO:1902600)2.75103952
108positive regulation of synapse assembly (GO:0051965)2.72916607
109response to insecticide (GO:0017085)2.72135162
110regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70822289
111kinetochore assembly (GO:0051382)2.70442753
112neurotransmitter transport (GO:0006836)2.69198803
113inner mitochondrial membrane organization (GO:0007007)2.69093428
114negative regulation of DNA recombination (GO:0045910)2.65864074
115centriole replication (GO:0007099)2.65413270
116chromosome condensation (GO:0030261)2.64427172
117mitochondrial respiratory chain complex assembly (GO:0033108)2.64204938
118regulation of short-term neuronal synaptic plasticity (GO:0048172)2.63413841
119regulation of centriole replication (GO:0046599)2.63006284
120regulation of glutamate secretion (GO:0014048)2.62526152
121histone H2A acetylation (GO:0043968)2.62509143
122negative regulation of nuclear division (GO:0051784)2.60340259
123postsynaptic membrane organization (GO:0001941)2.59199860
124establishment of chromosome localization (GO:0051303)2.58315786
125negative regulation of cell division (GO:0051782)2.57264074
126proton transport (GO:0015992)2.56935035
127positive regulation of mitotic sister chromatid separation (GO:1901970)2.56863745
128positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.56863745
129positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.56863745
130neurotransmitter secretion (GO:0007269)2.56705401
131negative regulation of microtubule depolymerization (GO:0007026)2.56469804
132behavioral response to cocaine (GO:0048148)2.56127268
133phagosome maturation (GO:0090382)2.55559042
134axonal fasciculation (GO:0007413)2.55445577
135long-term synaptic potentiation (GO:0060291)2.55410049
136anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.54928168
137cholesterol biosynthetic process (GO:0006695)2.53824373
138hydrogen transport (GO:0006818)2.53052567
139negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.52649287
140establishment of synaptic vesicle localization (GO:0097480)2.52396616
141synaptic vesicle transport (GO:0048489)2.52396616
142regulation of centrosome cycle (GO:0046605)2.50748382
143mitotic nuclear envelope disassembly (GO:0007077)2.50502793
144cullin deneddylation (GO:0010388)2.50469974
145ATP biosynthetic process (GO:0006754)2.49861889
146mitotic nuclear division (GO:0007067)2.49519059
147regulation of neurotransmitter levels (GO:0001505)2.48685668
148positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.47150203
149establishment of mitochondrion localization (GO:0051654)2.45786294
150purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.45598806
151synaptic transmission, glutamatergic (GO:0035249)2.45426232
152spermatid nucleus differentiation (GO:0007289)2.45243989
153regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.45029805
154regulation of sister chromatid cohesion (GO:0007063)2.44751290
155spindle assembly involved in mitosis (GO:0090307)2.44558258
156positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.44530691
157regulation of glutamate receptor signaling pathway (GO:1900449)2.44153710
158nucleobase catabolic process (GO:0046113)2.43406817
159regulation of collateral sprouting (GO:0048670)2.43291209
160regulation of DNA endoreduplication (GO:0032875)2.43135595
161CENP-A containing nucleosome assembly (GO:0034080)2.42405136
162ATP-dependent chromatin remodeling (GO:0043044)2.42276507
163positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.42239536
164neurotransmitter catabolic process (GO:0042135)2.41342783
165negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.40983971
166regulation of neurotransmitter uptake (GO:0051580)2.40924055
167purine nucleoside triphosphate biosynthetic process (GO:0009145)2.40737679
168protein K11-linked ubiquitination (GO:0070979)2.37493137
169cerebral cortex radially oriented cell migration (GO:0021799)2.36841990
170regulation of microtubule depolymerization (GO:0031114)2.36704939
171negative regulation of proteasomal protein catabolic process (GO:1901799)2.34961125
172regulation of microtubule cytoskeleton organization (GO:0070507)2.34046189
173synaptic vesicle maturation (GO:0016188)2.33489639
174nuclear envelope disassembly (GO:0051081)2.31863716
175membrane disassembly (GO:0030397)2.31863716
176establishment of mitotic spindle localization (GO:0040001)2.31782434
177olfactory bulb development (GO:0021772)2.31130409
178mitotic cell cycle (GO:0000278)2.30190132
179G2/M transition of mitotic cell cycle (GO:0000086)2.29718307

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAF15_26573619_Chip-Seq_HEK293_Human3.88233029
2* FOXM1_23109430_ChIP-Seq_U2OS_Human3.84616357
3EZH2_22144423_ChIP-Seq_EOC_Human3.69595352
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.67982061
5GBX2_23144817_ChIP-Seq_PC3_Human3.27734826
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.15730639
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.01075260
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.71109987
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.49514465
10FUS_26573619_Chip-Seq_HEK293_Human2.39524366
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.33016582
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31864175
13VDR_22108803_ChIP-Seq_LS180_Human2.30657116
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.28229863
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.28081498
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.26173323
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23037293
18E2F7_22180533_ChIP-Seq_HELA_Human2.22587156
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12849388
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12202682
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09558936
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08729850
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03450203
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03208567
25REST_21632747_ChIP-Seq_MESCs_Mouse1.94581139
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94044175
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.93368910
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91616211
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.90404696
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.89938556
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.87208237
32* EWS_26573619_Chip-Seq_HEK293_Human1.83985741
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.80516409
34P300_19829295_ChIP-Seq_ESCs_Human1.78160833
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.74913506
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.72744487
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71738540
38* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.70458941
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64454209
40IGF1R_20145208_ChIP-Seq_DFB_Human1.62948889
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62614469
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.60837976
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58360961
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57721972
45* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57274122
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50554766
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50056569
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45172770
49ER_23166858_ChIP-Seq_MCF-7_Human1.41299485
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41208070
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40817410
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38691608
53CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.38121658
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37171057
55SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37019808
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35043823
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.34753410
58ZNF274_21170338_ChIP-Seq_K562_Hela1.34514534
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34464072
60* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34166289
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.34100457
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30256366
63* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29281142
64RNF2_27304074_Chip-Seq_NSC_Mouse1.28968529
65FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.27085687
66SMAD4_21799915_ChIP-Seq_A2780_Human1.25551420
67IRF1_19129219_ChIP-ChIP_H3396_Human1.25137801
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.24011290
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21855358
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.19717129
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19110412
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19076951
73NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18495906
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18368529
75* MYC_18555785_ChIP-Seq_MESCs_Mouse1.18067778
76SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17709989
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16725889
78MTF2_20144788_ChIP-Seq_MESCs_Mouse1.16575016
79RARB_27405468_Chip-Seq_BRAIN_Mouse1.15698310
80EED_16625203_ChIP-ChIP_MESCs_Mouse1.15676112
81SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14751387
82JUN_21703547_ChIP-Seq_K562_Human1.14443699
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.14353988
84GATA1_26923725_Chip-Seq_HPCs_Mouse1.12928852
85EZH2_18974828_ChIP-Seq_MESCs_Mouse1.10812142
86RNF2_18974828_ChIP-Seq_MESCs_Mouse1.10812142
87NANOG_16153702_ChIP-ChIP_HESCs_Human1.10021245
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09378374
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08727198
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08552537
91SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08445832
92* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06052759
93SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.05632730
94PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05523501
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05329967
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05098394
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04224843
98HTT_18923047_ChIP-ChIP_STHdh_Human1.03572499
99VDR_23849224_ChIP-Seq_CD4+_Human1.03189453
100AR_21909140_ChIP-Seq_LNCAP_Human1.02591287
101SOX2_16153702_ChIP-ChIP_HESCs_Human1.01998049
102SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01710584
103E2F1_21310950_ChIP-Seq_MCF-7_Human1.01655171
104SOX9_26525672_Chip-Seq_HEART_Mouse1.00966324
105WT1_19549856_ChIP-ChIP_CCG9911_Human0.98622057
106* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98356087
107TAL1_26923725_Chip-Seq_HPCs_Mouse0.98234176
108ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98118259
109REST_19997604_ChIP-ChIP_NEURONS_Mouse0.97469331
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96990551
111AR_21572438_ChIP-Seq_LNCaP_Human0.96548232
112POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96489769
113* MYC_18940864_ChIP-ChIP_HL60_Human0.95839930
114SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95034337
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94338408
116PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94280677
117* FOXP3_21729870_ChIP-Seq_TREG_Human0.94050238
118* DCP1A_22483619_ChIP-Seq_HELA_Human0.93552431
119NANOG_18555785_Chip-Seq_ESCs_Mouse0.92222798
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91179960
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90707300
122PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.89868882
123* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.89686626
124HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88704156
125ELK1_19687146_ChIP-ChIP_HELA_Human0.88137865
126PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88131831
127* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87908554
128SRF_21415370_ChIP-Seq_HL-1_Mouse0.87296475
129* TTF2_22483619_ChIP-Seq_HELA_Human0.87264881
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86871101
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86871101
132KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.86709704
133POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.86481169
134PIAS1_25552417_ChIP-Seq_VCAP_Human0.85551535
135FLI1_27457419_Chip-Seq_LIVER_Mouse0.84612971
136TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84273137
137STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.82579589

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.47999094
2MP0001529_abnormal_vocalization3.98750689
3MP0004859_abnormal_synaptic_plasticity3.39036738
4MP0001968_abnormal_touch/_nociception3.05430221
5MP0002736_abnormal_nociception_after3.03245195
6MP0003635_abnormal_synaptic_transmissio2.99486042
7MP0001905_abnormal_dopamine_level2.99162585
8MP0002064_seizures2.94320740
9MP0009745_abnormal_behavioral_response2.83569899
10MP0006292_abnormal_olfactory_placode2.71929513
11MP0003693_abnormal_embryo_hatching2.59312551
12MP0003890_abnormal_embryonic-extraembry2.58188258
13MP0009046_muscle_twitch2.54837905
14MP0005423_abnormal_somatic_nervous2.52277515
15MP0002063_abnormal_learning/memory/cond2.49364017
16MP0002272_abnormal_nervous_system2.47716576
17MP0002572_abnormal_emotion/affect_behav2.42481261
18MP0004270_analgesia2.41600440
19MP0002735_abnormal_chemical_nociception2.35766550
20MP0006276_abnormal_autonomic_nervous2.33662134
21MP0001486_abnormal_startle_reflex2.21126117
22MP0001440_abnormal_grooming_behavior2.13513470
23MP0002734_abnormal_mechanical_nocicepti2.13377290
24MP0003329_amyloid_beta_deposits2.12538378
25MP0004142_abnormal_muscle_tone2.06833228
26MP0000566_synostosis2.05556639
27MP0003111_abnormal_nucleus_morphology2.03475126
28MP0002067_abnormal_sensory_capabilities1.99720882
29MP0002733_abnormal_thermal_nociception1.93460984
30MP0000920_abnormal_myelination1.92796266
31MP0003077_abnormal_cell_cycle1.90552564
32MP0001970_abnormal_pain_threshold1.84663367
33MP0000778_abnormal_nervous_system1.82332025
34MP0005551_abnormal_eye_electrophysiolog1.77604699
35MP0001501_abnormal_sleep_pattern1.76591342
36MP0005386_behavior/neurological_phenoty1.73988704
37MP0004924_abnormal_behavior1.73988704
38MP0001293_anophthalmia1.69972721
39MP0008789_abnormal_olfactory_epithelium1.69422942
40MP0010030_abnormal_orbit_morphology1.63796383
41MP0008058_abnormal_DNA_repair1.62762825
42MP0001984_abnormal_olfaction1.61503175
43MP0003122_maternal_imprinting1.59999901
44MP0008877_abnormal_DNA_methylation1.54411664
45MP0002938_white_spotting1.54272303
46MP0003937_abnormal_limbs/digits/tail_de1.51142194
47MP0002233_abnormal_nose_morphology1.45605217
48MP0005248_abnormal_Harderian_gland1.44177240
49MP0002557_abnormal_social/conspecific_i1.43225200
50MP0004742_abnormal_vestibular_system1.42625720
51MP0002184_abnormal_innervation1.40571908
52MP0002229_neurodegeneration1.38415069
53MP0003690_abnormal_glial_cell1.37272099
54MP0009379_abnormal_foot_pigmentation1.36446913
55MP0001188_hyperpigmentation1.36268698
56MP0009697_abnormal_copulation1.32701206
57MP0000537_abnormal_urethra_morphology1.32433720
58MP0002882_abnormal_neuron_morphology1.31639442
59MP0003632_abnormal_nervous_system1.31540872
60MP0002066_abnormal_motor_capabilities/c1.30475844
61MP0005646_abnormal_pituitary_gland1.29098569
62MP0004885_abnormal_endolymph1.28105070
63MP0004133_heterotaxia1.26036946
64MP0003634_abnormal_glial_cell1.25418534
65MP0003861_abnormal_nervous_system1.25269732
66MP0005409_darkened_coat_color1.24773729
67MP0003631_nervous_system_phenotype1.23793002
68MP0003119_abnormal_digestive_system1.22943627
69MP0001177_atelectasis1.22390866
70MP0006072_abnormal_retinal_apoptosis1.21793248
71MP0000955_abnormal_spinal_cord1.20662535
72MP0001963_abnormal_hearing_physiology1.20557465
73MP0002822_catalepsy1.19303070
74MP0001986_abnormal_taste_sensitivity1.18766333
75MP0001286_abnormal_eye_development1.18407656
76MP0002653_abnormal_ependyma_morphology1.17475761
77MP0008872_abnormal_physiological_respon1.17234422
78MP0000604_amyloidosis1.15915505
79MP0000647_abnormal_sebaceous_gland1.13239656
80MP0008569_lethality_at_weaning1.11393060
81MP0004811_abnormal_neuron_physiology1.11078370
82MP0000631_abnormal_neuroendocrine_gland1.10746652
83MP0003633_abnormal_nervous_system1.08336335
84MP0003755_abnormal_palate_morphology1.08000080
85MP0000049_abnormal_middle_ear1.06962224
86MP0005253_abnormal_eye_physiology1.06924182
87MP0003136_yellow_coat_color1.06682169
88MP0002697_abnormal_eye_size1.05650602
89MP0001485_abnormal_pinna_reflex1.04633594
90MP0001502_abnormal_circadian_rhythm1.04465966
91MP0002152_abnormal_brain_morphology1.04367860
92MP0002752_abnormal_somatic_nervous1.02519858
93MP0002234_abnormal_pharynx_morphology1.01736593
94MP0005645_abnormal_hypothalamus_physiol0.97824081
95MP0001346_abnormal_lacrimal_gland0.95222717
96MP0003385_abnormal_body_wall0.94793868
97MP0005410_abnormal_fertilization0.94421540
98MP0003567_abnormal_fetal_cardiomyocyte0.93994199
99MP0004957_abnormal_blastocyst_morpholog0.93818288
100MP0003121_genomic_imprinting0.93480661
101MP0005391_vision/eye_phenotype0.93452651
102MP0003315_abnormal_perineum_morphology0.93244784
103MP0003879_abnormal_hair_cell0.91642650
104MP0001929_abnormal_gametogenesis0.87653766
105MP0002210_abnormal_sex_determination0.87476812
106MP0008057_abnormal_DNA_replication0.87466753
107MP0003787_abnormal_imprinting0.87035660
108MP0005187_abnormal_penis_morphology0.86746001
109MP0002084_abnormal_developmental_patter0.86127549
110MP0004858_abnormal_nervous_system0.85465249
111MP0002638_abnormal_pupillary_reflex0.84847488
112MP0000026_abnormal_inner_ear0.84621054
113MP0001664_abnormal_digestion0.83556238
114MP0002090_abnormal_vision0.82775436
115MP0002085_abnormal_embryonic_tissue0.82157310
116MP0008932_abnormal_embryonic_tissue0.81420595
117MP0000427_abnormal_hair_cycle0.79836570
118MP0003011_delayed_dark_adaptation0.79541028
119MP0002876_abnormal_thyroid_physiology0.79081250
120MP0005195_abnormal_posterior_eye0.78926745
121MP0002102_abnormal_ear_morphology0.78415916
122MP0000372_irregular_coat_pigmentation0.76393785
123MP0006035_abnormal_mitochondrial_morpho0.74934705
124MP0010094_abnormal_chromosome_stability0.74804446
125MP0003123_paternal_imprinting0.73815487
126MP0005499_abnormal_olfactory_system0.73396669
127MP0005394_taste/olfaction_phenotype0.73396669
128MP0005171_absent_coat_pigmentation0.73016236
129MP0004147_increased_porphyrin_level0.72018763
130MP0006036_abnormal_mitochondrial_physio0.71795436
131MP0003950_abnormal_plasma_membrane0.71172060
132MP0002751_abnormal_autonomic_nervous0.70189744
133MP0003938_abnormal_ear_development0.69737277
134MP0003698_abnormal_male_reproductive0.69689971
135MP0002069_abnormal_eating/drinking_beha0.69152425
136MP0003718_maternal_effect0.68550186
137MP0005535_abnormal_body_temperature0.67574438
138MP0004043_abnormal_pH_regulation0.66021137

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.25865001
2Increased serum pyruvate (HP:0003542)4.15198091
3Abnormality of glycolysis (HP:0004366)4.15198091
4Cortical dysplasia (HP:0002539)3.93175768
5Abnormal mitochondria in muscle tissue (HP:0008316)3.87495069
6Myokymia (HP:0002411)3.80847838
7Mitochondrial inheritance (HP:0001427)3.80394607
8Focal motor seizures (HP:0011153)3.69682412
9Progressive macrocephaly (HP:0004481)3.64634574
10Acute encephalopathy (HP:0006846)3.47332750
11Neurofibrillary tangles (HP:0002185)3.39341473
12Volvulus (HP:0002580)3.38146067
13Degeneration of the lateral corticospinal tracts (HP:0002314)3.37124329
14Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.37124329
15Hepatocellular necrosis (HP:0001404)3.29183159
16Increased CSF lactate (HP:0002490)3.21784255
17Cerebral inclusion bodies (HP:0100314)3.10204887
18Atonic seizures (HP:0010819)3.07908097
19Leukodystrophy (HP:0002415)3.07182908
20Septo-optic dysplasia (HP:0100842)2.98721035
21Limb dystonia (HP:0002451)2.92417797
22Epileptic encephalopathy (HP:0200134)2.91335191
23Increased hepatocellular lipid droplets (HP:0006565)2.86062522
24Increased nuchal translucency (HP:0010880)2.84859156
25Pheochromocytoma (HP:0002666)2.83372507
26Neuroendocrine neoplasm (HP:0100634)2.79815760
27Abnormality of the corticospinal tract (HP:0002492)2.79303664
28Renal Fanconi syndrome (HP:0001994)2.76650624
29Visual hallucinations (HP:0002367)2.74480351
30Abnormal hair whorl (HP:0010721)2.70531694
31Gait imbalance (HP:0002141)2.62310105
32Parakeratosis (HP:0001036)2.61766200
33Oligodactyly (hands) (HP:0001180)2.58134213
34Absence seizures (HP:0002121)2.56512399
35Medial flaring of the eyebrow (HP:0010747)2.48749772
36Focal seizures (HP:0007359)2.48480461
37Dialeptic seizures (HP:0011146)2.46414420
38Progressive cerebellar ataxia (HP:0002073)2.43748988
39Congenital primary aphakia (HP:0007707)2.42164570
40Polyphagia (HP:0002591)2.39565443
41Optic disc pallor (HP:0000543)2.38098601
42Supranuclear gaze palsy (HP:0000605)2.37849985
43Nephrogenic diabetes insipidus (HP:0009806)2.37459868
44Colon cancer (HP:0003003)2.37310931
45Absent septum pellucidum (HP:0001331)2.36078325
46Vaginal atresia (HP:0000148)2.35910569
47Delusions (HP:0000746)2.35687038
48Genital tract atresia (HP:0001827)2.32348038
49Insidious onset (HP:0003587)2.32243089
50Termporal pattern (HP:0011008)2.32243089
51Cerebral hypomyelination (HP:0006808)2.31962631
52Lipid accumulation in hepatocytes (HP:0006561)2.31421051
53Generalized tonic-clonic seizures (HP:0002069)2.30112189
54Hepatic necrosis (HP:0002605)2.29882699
55Spastic gait (HP:0002064)2.27083337
56Meckel diverticulum (HP:0002245)2.25880736
57Hypoplastic pelvis (HP:0008839)2.25236571
58Hyperventilation (HP:0002883)2.22783209
59Abnormality of binocular vision (HP:0011514)2.22755734
60Diplopia (HP:0000651)2.22755734
61Abnormality of renal resorption (HP:0011038)2.21547641
62Stenosis of the external auditory canal (HP:0000402)2.19810371
63True hermaphroditism (HP:0010459)2.18010503
64Retinal dysplasia (HP:0007973)2.16207376
65Emotional lability (HP:0000712)2.15544462
66CNS hypomyelination (HP:0003429)2.14757794
67Truncal ataxia (HP:0002078)2.12420418
68Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.11599501
69Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.11320518
70Oligodactyly (HP:0012165)2.10390141
71Respiratory failure (HP:0002878)2.10278141
72Abnormality of the ileum (HP:0001549)2.10189220
73Hepatoblastoma (HP:0002884)2.09713174
74Abnormal eating behavior (HP:0100738)2.08123184
75Intestinal atresia (HP:0011100)2.07826754
76Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.07641824
77Abnormality of the septum pellucidum (HP:0007375)2.07279075
78Aplasia/Hypoplasia of the uvula (HP:0010293)2.07053996
79Aplasia/Hypoplasia of the sternum (HP:0006714)2.06906736
80Increased circulating renin level (HP:0000848)2.06046305
81Duodenal stenosis (HP:0100867)2.05915594
82Small intestinal stenosis (HP:0012848)2.05915594
83Abnormal ciliary motility (HP:0012262)2.05394170
84Abnormality of the duodenum (HP:0002246)2.04337518
85Anophthalmia (HP:0000528)2.03426608
86Hemivertebrae (HP:0002937)2.02838099
87Dysmetria (HP:0001310)2.02780740
88Optic nerve hypoplasia (HP:0000609)2.02761608
89Cerebral edema (HP:0002181)2.01990140
90Nephroblastoma (Wilms tumor) (HP:0002667)1.99638356
91Bifid tongue (HP:0010297)1.99358558
92Split foot (HP:0001839)1.98455483
93Degeneration of anterior horn cells (HP:0002398)1.97942482
94Abnormality of the anterior horn cell (HP:0006802)1.97942482
95Abnormality of chromosome stability (HP:0003220)1.97443813
96Aplasia/Hypoplasia of the sacrum (HP:0008517)1.97101159
97Cerebral hemorrhage (HP:0001342)1.96222906
98Urinary urgency (HP:0000012)1.94965637
99Embryonal renal neoplasm (HP:0011794)1.94699314
100Progressive inability to walk (HP:0002505)1.94205539
101Sensory axonal neuropathy (HP:0003390)1.93100486
102Scanning speech (HP:0002168)1.93088139
103X-linked dominant inheritance (HP:0001423)1.92282986
104Abnormality of midbrain morphology (HP:0002418)1.90615553
105Molar tooth sign on MRI (HP:0002419)1.90615553
106Anxiety (HP:0000739)1.90310869
107Hypothermia (HP:0002045)1.89674784
108Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88780982
109Preaxial hand polydactyly (HP:0001177)1.88740866
110Peripheral hypomyelination (HP:0007182)1.87045223
111Increased intramyocellular lipid droplets (HP:0012240)1.86203223
112Esophageal atresia (HP:0002032)1.85066188
113Chromosomal breakage induced by crosslinking agents (HP:0003221)1.84458931
114Lactic acidosis (HP:0003128)1.84414193
115Abnormality of the labia minora (HP:0012880)1.84115515
116Hypomagnesemia (HP:0002917)1.84046747
117Sloping forehead (HP:0000340)1.83984342
118Increased serum lactate (HP:0002151)1.83890895
119Medulloblastoma (HP:0002885)1.82755672
120Pancreatic cysts (HP:0001737)1.82493141
121Impaired vibration sensation in the lower limbs (HP:0002166)1.81985323
122Hypoplastic female external genitalia (HP:0012815)1.81261565
123Febrile seizures (HP:0002373)1.81260833
124Psychosis (HP:0000709)1.80493634
125Generalized myoclonic seizures (HP:0002123)1.79424301
126Atrophy/Degeneration involving motor neurons (HP:0007373)1.77883876
127Ankle clonus (HP:0011448)1.77871521
128Abnormal respiratory motile cilium morphology (HP:0005938)1.76871944
129Abnormal respiratory epithelium morphology (HP:0012253)1.76871944
130Autoamputation (HP:0001218)1.76821829
131Postaxial hand polydactyly (HP:0001162)1.76745852
132Abnormal respiratory motile cilium physiology (HP:0012261)1.76058305
133CNS demyelination (HP:0007305)1.75170680
1343-Methylglutaconic aciduria (HP:0003535)1.74820854
135Pancreatic fibrosis (HP:0100732)1.74690409
136Poor suck (HP:0002033)1.74521330
137Esotropia (HP:0000565)1.73646430
138Inability to walk (HP:0002540)1.73638193
139Exercise intolerance (HP:0003546)1.73405051
140Abnormal lung lobation (HP:0002101)1.72585974
141Lissencephaly (HP:0001339)1.72583224
142Glioma (HP:0009733)1.70860259
143Poor coordination (HP:0002370)1.70363990
144Renal hypoplasia (HP:0000089)1.70073405
145Specific learning disability (HP:0001328)1.69733085
146Myelomeningocele (HP:0002475)1.69503963
147Dynein arm defect of respiratory motile cilia (HP:0012255)1.69060608
148Absent/shortened dynein arms (HP:0200106)1.69060608
149Hyperglycinemia (HP:0002154)1.68919177
150Absent radius (HP:0003974)1.67828565
151Maternal diabetes (HP:0009800)1.67825864
152Supernumerary spleens (HP:0009799)1.67432311
153Labial hypoplasia (HP:0000066)1.67163065
154Drooling (HP:0002307)1.66059349
155Anencephaly (HP:0002323)1.65504014
156Chromsome breakage (HP:0040012)1.65351000
157Median cleft lip (HP:0000161)1.64805110
158Absent forearm bone (HP:0003953)1.63751644
159Aplasia involving forearm bones (HP:0009822)1.63751644
160Action tremor (HP:0002345)1.63667077
161Aqueductal stenosis (HP:0002410)1.63401927
162Sclerocornea (HP:0000647)1.62967823
163Gastrointestinal atresia (HP:0002589)1.62290474
164Short tibia (HP:0005736)1.61261409
165Dandy-Walker malformation (HP:0001305)1.61137244
166Rhabdomyosarcoma (HP:0002859)1.61064200
167Holoprosencephaly (HP:0001360)1.60083152
168Micropenis (HP:0000054)1.58838012
169Postaxial foot polydactyly (HP:0001830)1.58689390
170Abnormality of the lower motor neuron (HP:0002366)1.58586697
171Missing ribs (HP:0000921)1.56298892
172Amyotrophic lateral sclerosis (HP:0007354)1.55551046
173Aplasia/Hypoplasia of the tibia (HP:0005772)1.54963737
174Triphalangeal thumb (HP:0001199)1.53664002
175Papillary thyroid carcinoma (HP:0002895)1.53659185
176Pendular nystagmus (HP:0012043)1.52344414
177Astrocytoma (HP:0009592)1.50239802
178Abnormality of the astrocytes (HP:0100707)1.50239802
179Horseshoe kidney (HP:0000085)1.49282094

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.83420549
2MAP3K123.79502499
3PNCK2.87126383
4OXSR12.69555796
5STK392.55584885
6WEE12.23920999
7CASK2.22245973
8MAP3K42.13468423
9TRIM282.09445580
10SRPK12.02561662
11MKNK21.96694061
12STK161.95263504
13PBK1.94035993
14CDK191.92704836
15EPHA41.88994638
16NTRK31.87976344
17PLK41.83867012
18UHMK11.82438601
19MAPKAPK51.82174685
20MAP2K71.80451648
21MINK11.77885430
22TESK21.75795867
23CCNB11.70841386
24TSSK61.69209261
25PLK21.64657885
26MAP3K91.62018280
27EIF2AK31.61811195
28MST41.58350296
29CSNK1G31.50350837
30TNIK1.49474905
31ARAF1.43797543
32MARK11.39771975
33PLK31.38577804
34FGR1.37175084
35BRSK11.36229365
36RIPK41.34315904
37GRK51.28719443
38WNK41.28302806
39BCR1.27433185
40GRK61.26749604
41MAPK131.26457511
42FES1.25851092
43VRK11.25220756
44BRSK21.25024177
45NTRK21.20084333
46CSNK1G21.17860956
47PRKD31.15971149
48MAP2K41.13298591
49CDC71.12703429
50CDK141.08624251
51ZAK1.05815109
52CDK181.04246173
53NME11.03326138
54CDK151.02003002
55ERBB30.99591427
56NEK10.98639592
57PDK20.97000658
58BRAF0.96548653
59EPHB20.95073898
60MAP4K20.94102613
61AURKB0.91609190
62CDK11A0.90399325
63CAMK2B0.89787478
64VRK20.87643782
65GRK70.87610993
66AURKA0.87347303
67LIMK10.86594083
68EIF2AK20.86230090
69WNK30.84701976
70CSNK1G10.83926357
71KSR20.83251803
72NUAK10.80944504
73ADRBK20.80458371
74ERBB40.80110902
75STK38L0.78439101
76DAPK10.76557129
77CAMK2A0.75395769
78CDK50.74087958
79NTRK10.73843928
80STK30.72163474
81PLK10.72073777
82TTK0.71724475
83PRKCG0.71018080
84MELK0.70906735
85CLK10.68525945
86CSNK1A1L0.68139999
87ATR0.67232985
88LATS20.66267662
89PINK10.66159111
90SGK2230.62857489
91SGK4940.62857489
92NEK60.62199467
93KSR10.62040042
94ROCK20.59553220
95BMPR1B0.59510064
96BMPR20.53053833
97PKN10.52961084
98DYRK30.52609775
99PRPF4B0.52560243
100MAP3K130.51040203
101SYK0.50433863
102EIF2AK10.50293618
103PAK30.49600139
104STK100.48437386
105ADRBK10.48293966
106DYRK1A0.48115771
107ATM0.46638573
108TAF10.45874600
109MKNK10.43739930
110MAP3K60.41008998
111DYRK20.41004718
112NEK20.40294927
113PAK60.39023240
114CDK30.37841428
115ERBB20.36445905
116TNK20.35395979
117PRKCQ0.34484559
118FGFR10.34254415
119CAMK2D0.33807646
120PTK2B0.33462360
121CDK80.33404027
122CSNK1E0.33363805
123CHEK10.32222304
124ALK0.32116889
125PRKCI0.31920436
126FYN0.30402907
127RPS6KA40.29845351
128YES10.25444582
129CAMK2G0.25151456
130MAPK40.25061134
131CDK10.24721532
132PRKCE0.24704304
133LCK0.24455170
134CHEK20.23976144

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.40791627
2Parkinsons disease_Homo sapiens_hsa050123.64569804
3Nicotine addiction_Homo sapiens_hsa050333.55003038
4Collecting duct acid secretion_Homo sapiens_hsa049663.34556512
5Synaptic vesicle cycle_Homo sapiens_hsa047212.95775515
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.93671183
7Alzheimers disease_Homo sapiens_hsa050102.79177685
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.56865272
9Proteasome_Homo sapiens_hsa030502.54733922
10Huntingtons disease_Homo sapiens_hsa050162.45234121
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.21362630
12Fatty acid elongation_Homo sapiens_hsa000622.19097464
13GABAergic synapse_Homo sapiens_hsa047272.09128646
14Fanconi anemia pathway_Homo sapiens_hsa034601.96154669
15Vibrio cholerae infection_Homo sapiens_hsa051101.86297023
16Propanoate metabolism_Homo sapiens_hsa006401.76821538
17Morphine addiction_Homo sapiens_hsa050321.75895760
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.73234839
19Steroid biosynthesis_Homo sapiens_hsa001001.69509520
20Serotonergic synapse_Homo sapiens_hsa047261.67601440
21Glutamatergic synapse_Homo sapiens_hsa047241.61467703
22Dopaminergic synapse_Homo sapiens_hsa047281.60732013
23Amphetamine addiction_Homo sapiens_hsa050311.59921095
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59600726
25Oocyte meiosis_Homo sapiens_hsa041141.57788564
26Long-term potentiation_Homo sapiens_hsa047201.51999077
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.51812626
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.50611972
29Circadian entrainment_Homo sapiens_hsa047131.41096860
30Phototransduction_Homo sapiens_hsa047441.38931779
31Ribosome_Homo sapiens_hsa030101.36343026
32Long-term depression_Homo sapiens_hsa047301.34305624
33Olfactory transduction_Homo sapiens_hsa047401.34215318
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33539319
35Base excision repair_Homo sapiens_hsa034101.32118438
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31322206
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.30805488
38Protein export_Homo sapiens_hsa030601.28139694
39Taste transduction_Homo sapiens_hsa047421.27946816
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26123974
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22740000
42RNA polymerase_Homo sapiens_hsa030201.18513864
43Cardiac muscle contraction_Homo sapiens_hsa042601.18033625
44Cocaine addiction_Homo sapiens_hsa050301.16695774
45Salivary secretion_Homo sapiens_hsa049701.15862871
46Fatty acid metabolism_Homo sapiens_hsa012121.14617895
47Hippo signaling pathway_Homo sapiens_hsa043901.11898712
48Pyruvate metabolism_Homo sapiens_hsa006201.10468370
49Renin secretion_Homo sapiens_hsa049241.09281580
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07952492
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07189960
52Ether lipid metabolism_Homo sapiens_hsa005651.07035919
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06862723
54mRNA surveillance pathway_Homo sapiens_hsa030151.03880991
55Gastric acid secretion_Homo sapiens_hsa049711.01487901
56Rheumatoid arthritis_Homo sapiens_hsa053230.99709966
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98553843
58Basal cell carcinoma_Homo sapiens_hsa052170.96946687
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96237690
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93864889
61beta-Alanine metabolism_Homo sapiens_hsa004100.93650544
62Mismatch repair_Homo sapiens_hsa034300.91157500
63Folate biosynthesis_Homo sapiens_hsa007900.90162079
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88777088
65Gap junction_Homo sapiens_hsa045400.88308754
66Phagosome_Homo sapiens_hsa041450.88038774
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84516431
68p53 signaling pathway_Homo sapiens_hsa041150.83910737
69Spliceosome_Homo sapiens_hsa030400.78791159
70Alcoholism_Homo sapiens_hsa050340.78540627
71Cholinergic synapse_Homo sapiens_hsa047250.78451051
72Butanoate metabolism_Homo sapiens_hsa006500.78113329
73TGF-beta signaling pathway_Homo sapiens_hsa043500.75028655
74Wnt signaling pathway_Homo sapiens_hsa043100.74777450
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71838671
76Nitrogen metabolism_Homo sapiens_hsa009100.71533744
77Fatty acid degradation_Homo sapiens_hsa000710.71270147
78Arginine and proline metabolism_Homo sapiens_hsa003300.71005059
79Biosynthesis of amino acids_Homo sapiens_hsa012300.70636971
80Axon guidance_Homo sapiens_hsa043600.69559812
81Nucleotide excision repair_Homo sapiens_hsa034200.68545742
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67237301
83Hedgehog signaling pathway_Homo sapiens_hsa043400.67191565
84Calcium signaling pathway_Homo sapiens_hsa040200.66773330
85Non-homologous end-joining_Homo sapiens_hsa034500.64829585
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64624323
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63712665
88Cell cycle_Homo sapiens_hsa041100.63159977
89Peroxisome_Homo sapiens_hsa041460.61653820
90Homologous recombination_Homo sapiens_hsa034400.58546154
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58452210
92Vitamin B6 metabolism_Homo sapiens_hsa007500.57075511
93Carbon metabolism_Homo sapiens_hsa012000.56812295
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56530281
95Selenocompound metabolism_Homo sapiens_hsa004500.54137678
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52174641
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49936115
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46728254
99Basal transcription factors_Homo sapiens_hsa030220.46265907
100Metabolic pathways_Homo sapiens_hsa011000.45234346
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44982997
102DNA replication_Homo sapiens_hsa030300.44775525
103RNA degradation_Homo sapiens_hsa030180.44453284
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43160353
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42796608
106Oxytocin signaling pathway_Homo sapiens_hsa049210.42677359
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41434996
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41230127
109GnRH signaling pathway_Homo sapiens_hsa049120.41149086
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40663541
111Histidine metabolism_Homo sapiens_hsa003400.40214269
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38886604
113N-Glycan biosynthesis_Homo sapiens_hsa005100.38788170
114Primary immunodeficiency_Homo sapiens_hsa053400.38650434
115Sphingolipid metabolism_Homo sapiens_hsa006000.38515608
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.38124176
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37357126
118Pyrimidine metabolism_Homo sapiens_hsa002400.33905926
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33477339
120Purine metabolism_Homo sapiens_hsa002300.33004915
121RNA transport_Homo sapiens_hsa030130.29098607
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.29073094
123Insulin secretion_Homo sapiens_hsa049110.27735970
124Melanogenesis_Homo sapiens_hsa049160.27270125
125Autoimmune thyroid disease_Homo sapiens_hsa053200.27148928
126Thyroid hormone synthesis_Homo sapiens_hsa049180.27145433
127Aldosterone synthesis and secretion_Homo sapiens_hsa049250.26914453
128Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.25204260
129Sulfur metabolism_Homo sapiens_hsa009200.24968321
130Asthma_Homo sapiens_hsa053100.22431298
131Glutathione metabolism_Homo sapiens_hsa004800.22379666
132African trypanosomiasis_Homo sapiens_hsa051430.20891665
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20702454
134cAMP signaling pathway_Homo sapiens_hsa040240.18609730
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.18165751
136Estrogen signaling pathway_Homo sapiens_hsa049150.16356201
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.15444742

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