ARL6IP1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of glycogen (starch) synthase activity (GO:2000465)8.22291723
2cytoplasmic mRNA processing body assembly (GO:0033962)7.87869290
3sequestering of actin monomers (GO:0042989)7.13283647
4regulation of action potential (GO:0098900)6.78219251
5neuron fate determination (GO:0048664)6.50343925
6regulation of NFAT protein import into nucleus (GO:0051532)6.38266826
7behavioral response to nicotine (GO:0035095)6.32106475
8negative regulation of glycogen biosynthetic process (GO:0045719)6.21766878
9protein localization to microtubule (GO:0035372)5.46153433
10negative regulation of glycogen metabolic process (GO:0070874)5.25750855
11regulation of branching involved in salivary gland morphogenesis (GO:0060693)5.17292268
12fusion of sperm to egg plasma membrane (GO:0007342)5.09517235
13neurofilament cytoskeleton organization (GO:0060052)4.81098057
14regulation of meiosis I (GO:0060631)4.63079391
15negative regulation of cardiac muscle hypertrophy (GO:0010614)4.52915579
16negative regulation of dendrite morphogenesis (GO:0050774)4.50608075
17regulation of cell communication by electrical coupling (GO:0010649)4.50238296
18negative regulation of dendrite development (GO:2000171)4.41531564
19regulation of acrosome reaction (GO:0060046)4.36485851
20response to auditory stimulus (GO:0010996)4.23945527
21positive regulation of sodium ion transmembrane transporter activity (GO:2000651)4.08913066
22negative regulation of muscle hypertrophy (GO:0014741)4.07954968
23type B pancreatic cell proliferation (GO:0044342)4.03170333
24plasma membrane fusion (GO:0045026)3.89504740
25ER overload response (GO:0006983)3.81648194
26serotonin metabolic process (GO:0042428)3.77818971
27platelet dense granule organization (GO:0060155)3.75087299
28neuromuscular process controlling posture (GO:0050884)3.74226512
29spermatid nucleus differentiation (GO:0007289)3.65759579
30preassembly of GPI anchor in ER membrane (GO:0016254)3.64873006
31neuron fate specification (GO:0048665)3.62406116
32regulation of DNA methylation (GO:0044030)3.60347105
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.57729560
34cell migration in hindbrain (GO:0021535)3.57281340
35regulation of cell maturation (GO:1903429)3.50095551
36response to pheromone (GO:0019236)3.48943404
37primary amino compound metabolic process (GO:1901160)3.45278293
38neuron remodeling (GO:0016322)3.45157827
39positive regulation of meiosis (GO:0045836)3.44932689
40embryonic body morphogenesis (GO:0010172)3.30182372
41neuronal action potential (GO:0019228)3.29692144
42histone H4-K12 acetylation (GO:0043983)3.27870042
43protein localization to microtubule cytoskeleton (GO:0072698)3.24804231
44regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.23160526
45positive regulation of meiotic cell cycle (GO:0051446)3.21768825
46positive regulation of cell-cell adhesion (GO:0022409)3.15918247
47piRNA metabolic process (GO:0034587)3.13160837
48protein polyglutamylation (GO:0018095)3.08838689
49negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.06882583
50energy coupled proton transport, down electrochemical gradient (GO:0015985)3.06286526
51ATP synthesis coupled proton transport (GO:0015986)3.06286526
52epithelial cell differentiation involved in kidney development (GO:0035850)3.04462197
53central nervous system projection neuron axonogenesis (GO:0021952)3.04216794
54membrane assembly (GO:0071709)3.02039559
55positive regulation by host of viral transcription (GO:0043923)3.00008947
56positive regulation of membrane potential (GO:0045838)2.98694278
57detection of light stimulus involved in visual perception (GO:0050908)2.97809342
58detection of light stimulus involved in sensory perception (GO:0050962)2.97809342
59replication fork processing (GO:0031297)2.92937761
60pyrimidine nucleobase catabolic process (GO:0006208)2.90248819
61neuromuscular synaptic transmission (GO:0007274)2.88047502
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.88034047
63postsynaptic membrane organization (GO:0001941)2.86550966
64acrosome assembly (GO:0001675)2.82806362
65response to insecticide (GO:0017085)2.82188899
66vitamin transmembrane transport (GO:0035461)2.80125960
67vesicle transport along microtubule (GO:0047496)2.78794737
68presynaptic membrane assembly (GO:0097105)2.75221010
69thalamus development (GO:0021794)2.74929165
70membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.74812929
71transmission of nerve impulse (GO:0019226)2.74750757
72maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.71706566
73positive regulation of sodium ion transmembrane transport (GO:1902307)2.70056342
74protein localization to cytoskeleton (GO:0044380)2.69640400
75epithelial cilium movement (GO:0003351)2.69289829
76nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.68464890
77negative regulation of translation, ncRNA-mediated (GO:0040033)2.64601972
78regulation of translation, ncRNA-mediated (GO:0045974)2.64601972
79negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.64601972
80microtubule severing (GO:0051013)2.63721478
81adenosine metabolic process (GO:0046085)2.63217484
82RNA destabilization (GO:0050779)2.62762420
83somite rostral/caudal axis specification (GO:0032525)2.62524501
84synaptic transmission, cholinergic (GO:0007271)2.60860583
85neural tube formation (GO:0001841)2.58264449
86mitochondrial respiratory chain complex I assembly (GO:0032981)2.57179454
87NADH dehydrogenase complex assembly (GO:0010257)2.57179454
88mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.57179454
89ADP metabolic process (GO:0046031)2.55948684
90regulation of gene expression by genetic imprinting (GO:0006349)2.55862132
91retina layer formation (GO:0010842)2.55690346
92protein complex biogenesis (GO:0070271)2.54742349
93neuron cell-cell adhesion (GO:0007158)2.54354628
94neurotransmitter catabolic process (GO:0042135)2.52348610
95male meiosis (GO:0007140)2.51678499
96regulation of calcium ion-dependent exocytosis (GO:0017158)2.50331732
97regulation of glucan biosynthetic process (GO:0010962)2.49578703
98regulation of glycogen biosynthetic process (GO:0005979)2.49578703
99adaptation of signaling pathway (GO:0023058)2.49408991
100positive regulation of action potential (GO:0045760)10.5423332

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.71526343
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.23919771
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.43204206
4GBX2_23144817_ChIP-Seq_PC3_Human3.02538404
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.83360781
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.82311274
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.79282257
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.68291151
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.55567742
10VDR_22108803_ChIP-Seq_LS180_Human2.50003330
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.39916871
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36758880
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.36351724
14PCGF2_27294783_Chip-Seq_NPCs_Mouse2.35642857
15FUS_26573619_Chip-Seq_HEK293_Human2.34625697
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25918279
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21276649
18ZNF274_21170338_ChIP-Seq_K562_Hela2.16923385
19P300_19829295_ChIP-Seq_ESCs_Human2.08438708
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.05420237
21SUZ12_27294783_Chip-Seq_NPCs_Mouse1.97681393
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97256820
23RNF2_27304074_Chip-Seq_NSC_Mouse1.81282396
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80220970
25NFE2_27457419_Chip-Seq_LIVER_Mouse1.72131734
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69642116
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67958087
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65434767
29REST_21632747_ChIP-Seq_MESCs_Mouse1.65090403
30TAF15_26573619_Chip-Seq_HEK293_Human1.64075690
31TOP2B_26459242_ChIP-Seq_MCF-7_Human1.63095416
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61133406
33SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.60693897
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.60524213
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.58969270
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57941493
37EWS_26573619_Chip-Seq_HEK293_Human1.56733862
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.56688979
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.56182773
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55912212
41TCF4_18268006_ChIP-ChIP_LS174T_Human1.55718777
42SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.54713915
43SMAD4_21799915_ChIP-Seq_A2780_Human1.50344397
44JUN_21703547_ChIP-Seq_K562_Human1.43014046
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40784819
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.38946166
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36207050
48RUNX2_22187159_ChIP-Seq_PCA_Human1.33979247
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31671739
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.30412766
51TP53_22573176_ChIP-Seq_HFKS_Human1.30032120
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29977868
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.28970880
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28421913
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.28149356
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27510996
57DROSHA_22980978_ChIP-Seq_HELA_Human1.24573127
58OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23791654
59TAL1_26923725_Chip-Seq_HPCs_Mouse1.22381743
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21886600
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.19883464
62BCAT_22108803_ChIP-Seq_LS180_Human1.19728524
63FOXM1_23109430_ChIP-Seq_U2OS_Human1.17542078
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16962546
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.16726167
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14596155
67AR_25329375_ChIP-Seq_VCAP_Human1.13916356
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11827516
69ER_23166858_ChIP-Seq_MCF-7_Human1.11532496
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10028276
71TP53_18474530_ChIP-ChIP_U2OS_Human1.09451418
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.08387244
73EZH2_27294783_Chip-Seq_ESCs_Mouse1.07313494
74SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06336916
75SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05849869
76FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04835410
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04736843
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04358991
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04332245
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02160047
81RNF2_27304074_Chip-Seq_ESCs_Mouse1.01316107
82JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01315473
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.00832082
84AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99801972
85SOX2_19829295_ChIP-Seq_ESCs_Human0.99093749
86NANOG_19829295_ChIP-Seq_ESCs_Human0.99093749
87SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98695334
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98642476
89TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98165730
90SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97472957
91AR_21572438_ChIP-Seq_LNCaP_Human0.97031441
92P53_22387025_ChIP-Seq_ESCs_Mouse0.96676799
93TCF4_23295773_ChIP-Seq_U87_Human0.96582324
94JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96409127
95NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96356679
96SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.94658216
97NCOR_22424771_ChIP-Seq_293T_Human0.94450192
98RING1B_27294783_Chip-Seq_ESCs_Mouse0.94280486
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91309434
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89246110

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.56015111
2MP0003283_abnormal_digestive_organ5.66314978
3MP0002638_abnormal_pupillary_reflex3.79757739
4MP0009379_abnormal_foot_pigmentation3.34936521
5MP0010386_abnormal_urinary_bladder2.42876941
6MP0001529_abnormal_vocalization2.35653525
7MP0008877_abnormal_DNA_methylation2.20228593
8MP0002938_white_spotting2.18973090
9MP0004270_analgesia2.17135970
10MP0000778_abnormal_nervous_system2.12295185
11MP0004133_heterotaxia2.12096776
12MP0004147_increased_porphyrin_level1.92991851
13MP0002095_abnormal_skin_pigmentation1.92981090
14MP0006276_abnormal_autonomic_nervous1.86983787
15MP0002735_abnormal_chemical_nociception1.85948654
16MP0005174_abnormal_tail_pigmentation1.82068708
17MP0003122_maternal_imprinting1.80351021
18MP0004142_abnormal_muscle_tone1.76387457
19MP0002277_abnormal_respiratory_mucosa1.75054269
20MP0003195_calcinosis1.68702074
21MP0005423_abnormal_somatic_nervous1.68510362
22MP0003121_genomic_imprinting1.61675758
23MP0002734_abnormal_mechanical_nocicepti1.56347424
24MP0004885_abnormal_endolymph1.55910556
25MP0003011_delayed_dark_adaptation1.52315462
26MP0002272_abnormal_nervous_system1.50935463
27MP0000566_synostosis1.48392686
28MP0002572_abnormal_emotion/affect_behav1.48080970
29MP0002557_abnormal_social/conspecific_i1.47020439
30MP0002064_seizures1.46153458
31MP0002837_dystrophic_cardiac_calcinosis1.45824608
32MP0003890_abnormal_embryonic-extraembry1.41534135
33MP0003880_abnormal_central_pattern1.41333422
34MP0003635_abnormal_synaptic_transmissio1.39861243
35MP0009745_abnormal_behavioral_response1.39783845
36MP0005085_abnormal_gallbladder_physiolo1.36255960
37MP0002102_abnormal_ear_morphology1.36162646
38MP0000015_abnormal_ear_pigmentation1.35747210
39MP0001970_abnormal_pain_threshold1.35460962
40MP0002063_abnormal_learning/memory/cond1.35423997
41MP0001293_anophthalmia1.35154908
42MP0003119_abnormal_digestive_system1.28016128
43MP0006054_spinal_hemorrhage1.27662585
44MP0006072_abnormal_retinal_apoptosis1.24713555
45MP0001905_abnormal_dopamine_level1.24548935
46MP0000955_abnormal_spinal_cord1.20827233
47MP0005084_abnormal_gallbladder_morpholo1.17889583
48MP0000383_abnormal_hair_follicle1.14103673
49MP0002184_abnormal_innervation1.10175334
50MP0003787_abnormal_imprinting1.07483592
51MP0001485_abnormal_pinna_reflex1.05402794
52MP0005253_abnormal_eye_physiology1.04889057
53MP0000026_abnormal_inner_ear1.03168675
54MP0002928_abnormal_bile_duct1.01672708
55MP0001486_abnormal_startle_reflex1.01316825
56MP0002160_abnormal_reproductive_system1.00755484
57MP0002733_abnormal_thermal_nociception1.00153999
58MP0004742_abnormal_vestibular_system0.97245224
59MP0002752_abnormal_somatic_nervous0.96941313
60MP0004924_abnormal_behavior0.96892492
61MP0005386_behavior/neurological_phenoty0.96892492
62MP0008872_abnormal_physiological_respon0.95849595
63MP0003878_abnormal_ear_physiology0.93554880
64MP0005377_hearing/vestibular/ear_phenot0.93554880
65MP0009250_abnormal_appendicular_skeleto0.90491620
66MP0005551_abnormal_eye_electrophysiolog0.88071706
67MP0003937_abnormal_limbs/digits/tail_de0.88020581
68MP0005448_abnormal_energy_balance0.87401000
69MP0010329_abnormal_lipoprotein_level0.86983133
70MP0001440_abnormal_grooming_behavior0.86655087
71MP0003137_abnormal_impulse_conducting0.86076358
72MP0005645_abnormal_hypothalamus_physiol0.84537274
73MP0001984_abnormal_olfaction0.84384756
74MP0005075_abnormal_melanosome_morpholog0.79778609
75MP0005389_reproductive_system_phenotype0.79398014
76MP0001944_abnormal_pancreas_morphology0.77985254
77MP0002882_abnormal_neuron_morphology0.77638853
78MP0000371_diluted_coat_color0.77444286
79MP0002210_abnormal_sex_determination0.77426757
80MP0003755_abnormal_palate_morphology0.73963957
81MP0005195_abnormal_posterior_eye0.73177438
82MP0003938_abnormal_ear_development0.72976594
83MP0003123_paternal_imprinting0.72469383
84MP0002751_abnormal_autonomic_nervous0.71439375
85MP0002282_abnormal_trachea_morphology0.71270070
86MP0010770_preweaning_lethality0.69849756
87MP0002082_postnatal_lethality0.69849756
88MP0002152_abnormal_brain_morphology0.69457149
89MP0002909_abnormal_adrenal_gland0.68679781
90MP0003948_abnormal_gas_homeostasis0.68499707
91MP0002067_abnormal_sensory_capabilities0.68380596
92MP0002090_abnormal_vision0.67954374
93MP0002081_perinatal_lethality0.66381362
94MP0000538_abnormal_urinary_bladder0.64986361
95MP0001727_abnormal_embryo_implantation0.63633031
96MP0002066_abnormal_motor_capabilities/c0.63122096
97MP0004811_abnormal_neuron_physiology0.62830738
98MP0001324_abnormal_eye_pigmentation0.62542092
99MP0002653_abnormal_ependyma_morphology0.61906258
100MP0003935_abnormal_craniofacial_develop0.61648611

Predicted human phenotypes

RankGene SetZ-score
1Congenital, generalized hypertrichosis (HP:0004540)5.24174247
2Limb hypertonia (HP:0002509)4.30472462
3Amyotrophic lateral sclerosis (HP:0007354)4.20422351
4Thyroid-stimulating hormone excess (HP:0002925)3.98198638
5Abnormal pupillary function (HP:0007686)3.84907239
6Limb dystonia (HP:0002451)3.80530080
7Congenital sensorineural hearing impairment (HP:0008527)3.70931251
8Pendular nystagmus (HP:0012043)3.61517441
9Type 2 muscle fiber atrophy (HP:0003554)3.54219661
1011 pairs of ribs (HP:0000878)3.44671103
11Abnormality of the corticospinal tract (HP:0002492)3.41432052
12Inability to walk (HP:0002540)3.37411767
13Aplasia/Hypoplasia of the tibia (HP:0005772)3.07661234
14Hypothermia (HP:0002045)3.06139877
15Pancreatic cysts (HP:0001737)3.02089622
16Hyperglycinemia (HP:0002154)2.95164748
17Spastic tetraparesis (HP:0001285)2.92131949
18Abnormality of midbrain morphology (HP:0002418)2.90985939
19Molar tooth sign on MRI (HP:0002419)2.90985939
20Increased hepatocellular lipid droplets (HP:0006565)2.90244618
21Delayed CNS myelination (HP:0002188)2.89853395
22Lissencephaly (HP:0001339)2.87656219
23Renal Fanconi syndrome (HP:0001994)2.84192680
24Short tibia (HP:0005736)2.82862775
25Testicular atrophy (HP:0000029)2.78468354
26Mitochondrial inheritance (HP:0001427)2.75827526
27Muscle fiber atrophy (HP:0100295)2.70772983
28Disproportionate short-trunk short stature (HP:0003521)2.70088522
29Pancreatic islet-cell hyperplasia (HP:0004510)2.66529755
30Pancreatic fibrosis (HP:0100732)2.64716090
31Episodic fever (HP:0001954)2.62454948
32Hypoplasia of the brainstem (HP:0002365)2.57042562
33Aplasia/Hypoplasia of the brainstem (HP:0007362)2.57042562
34Acute necrotizing encephalopathy (HP:0006965)2.55594243
35Lipid accumulation in hepatocytes (HP:0006561)2.50060312
36Acute encephalopathy (HP:0006846)2.49377243
37Mesomelia (HP:0003027)2.47734937
38Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.39940819
39Short 4th metacarpal (HP:0010044)2.39940819
40Hypoplasia of the capital femoral epiphysis (HP:0003090)2.36228024
41Elfin facies (HP:0004428)2.34889283
42Increased CSF lactate (HP:0002490)2.26804489
43Submucous cleft hard palate (HP:0000176)2.24109940
44Stomatitis (HP:0010280)2.21027580
45Focal motor seizures (HP:0011153)2.16979554
46True hermaphroditism (HP:0010459)2.16055451
47Abnormality of secondary sexual hair (HP:0009888)2.15381039
48Abnormality of the axillary hair (HP:0100134)2.15381039
49Exertional dyspnea (HP:0002875)2.12136809
50Progressive macrocephaly (HP:0004481)2.08920850
51Abnormality of renal resorption (HP:0011038)2.08911765
52Abnormal biliary tract physiology (HP:0012439)2.05104898
53Bile duct proliferation (HP:0001408)2.05104898
54Abnormality of the vertebral endplates (HP:0005106)2.01197266
55Absent epiphyses (HP:0010577)1.99675326
56Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.99675326
57Enlarged epiphyses (HP:0010580)1.98721395
58Status epilepticus (HP:0002133)1.93539452
59Methylmalonic acidemia (HP:0002912)1.92192775
60Pachygyria (HP:0001302)1.88758498
61Abnormal mitochondria in muscle tissue (HP:0008316)1.87947182
62Nasal speech (HP:0001611)1.84782444
63Cystic liver disease (HP:0006706)1.82762380
64Median cleft lip (HP:0000161)1.82358093
65Toxemia of pregnancy (HP:0100603)1.82156514
66Atrophy/Degeneration involving motor neurons (HP:0007373)1.82146773
67Hepatic necrosis (HP:0002605)1.81601358
68Barrel-shaped chest (HP:0001552)1.80738543
69Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.80558946
70Parakeratosis (HP:0001036)1.76476558
71Abnormality of the 4th metacarpal (HP:0010012)1.74632423
72Renal cortical cysts (HP:0000803)1.74242029
73Polyphagia (HP:0002591)1.74035252
74Intestinal atresia (HP:0011100)1.73540738
75Genu varum (HP:0002970)1.73099535
76Hepatocellular necrosis (HP:0001404)1.72509371
77Congenital stationary night blindness (HP:0007642)1.71876531
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.70688274
79Poor speech (HP:0002465)1.69083414
80Decreased muscle mass (HP:0003199)1.67611793
81Polyuria (HP:0000103)1.67306853
82Adrenal hypoplasia (HP:0000835)1.66704330
83Depressed nasal tip (HP:0000437)1.66230668
84Abnormality of the renal cortex (HP:0011035)1.65230090
85Neonatal hypoglycemia (HP:0001998)1.63196704
86Aqueductal stenosis (HP:0002410)1.63154907
87Abnormality of the neuromuscular junction (HP:0003398)1.62946849
88Fatigable weakness (HP:0003473)1.62946849
89Constricted visual fields (HP:0001133)1.62901610
90Triphalangeal thumb (HP:0001199)1.62378633
91Cerebral edema (HP:0002181)1.61570895
92Supernumerary spleens (HP:0009799)1.61377774
93Decreased circulating renin level (HP:0003351)1.60925798
94Abnormality of the diencephalon (HP:0010662)1.60849501
95Abnormality of endocrine pancreas physiology (HP:0012093)1.60523766
96Abnormality of the pancreatic islet cells (HP:0006476)1.60523766
97Flat cornea (HP:0007720)1.59947634
98Abnormality of the labia minora (HP:0012880)1.59616417
99Abnormality of the carotid arteries (HP:0005344)1.58785034
100Malignant hyperthermia (HP:0002047)1.57717090

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK7.59238662
2CAMK1G3.62477800
3TAF13.19676787
4SIK23.15519609
5MAP3K102.94912044
6MINK12.89284388
7NUAK12.50778076
8SGK22.28070088
9ERBB32.19438990
10MARK12.18566934
11PASK2.05217158
12PRKCH1.97444013
13SGK2231.86139972
14SGK4941.86139972
15FRK1.85393390
16TYRO31.82811099
17ADRBK21.77754134
18TRIM281.62476684
19INSRR1.55496738
20TLK11.54822566
21RPS6KA21.49340778
22WEE11.49277701
23MAP2K71.40110279
24ZAK1.37816971
25SGK31.35722130
26DYRK21.34031550
27LIMK11.26109020
28VRK11.23675720
29PRKCG1.22119197
30RPS6KA61.19996315
31TAOK31.18441581
32MAP3K41.14090497
33MAPK131.13190506
34CASK1.05061308
35PLK41.03377382
36TXK1.02200726
37PINK11.01394402
38VRK21.01275137
39RPS6KC11.00627503
40RPS6KL11.00627503
41NTRK30.98914806
42TNIK0.97872819
43BMPR1B0.97819568
44MAP2K10.95236553
45WNK30.81622421
46DDR20.81221487
47SIK10.77618695
48SRPK10.77211606
49TSSK60.76004788
50PRKCZ0.74840363
51TGFBR10.74745173
52BCKDK0.71908482
53BUB10.71289071
54GRK10.69372369
55PLK30.69282130
56ADRBK10.68699589
57ARAF0.66628745
58MKNK20.64963265
59PRKCE0.60979705
60CLK10.60843069
61GRK50.60151369
62CAMK10.58524960
63AURKA0.58100820
64PAK30.56796459
65SGK10.53975661
66DMPK0.53067266
67CDC70.52874086
68STK160.51106196
69RAF10.50351105
70SIK30.48740919
71TIE10.46554928
72PIK3CA0.46419409
73ATR0.45033066
74MUSK0.42595254
75ROCK20.41437228
76CAMK1D0.40480656
77PIM20.37139257
78CDC42BPA0.35398156
79MATK0.33822214
80PRKG10.33658640
81PIK3CG0.33589053
82CDK30.33019406
83PHKG20.32921075
84PHKG10.32921075
85FLT30.32663457
86OBSCN0.30811428
87RPS6KB10.29707548
88PLK20.28073172
89EIF2AK20.28066119
90UHMK10.27841071
91MARK30.27721590
92MAP4K20.27192347
93PRKCB0.26637414
94PRKCD0.26431503
95DYRK30.24890897
96STK110.24544993
97MAPK150.24262087
98PRKACA0.23541493
99PLK10.23413885
100CAMK2A0.23201529

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004504.40721464
2Protein export_Homo sapiens_hsa030603.40521407
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.29019681
4Oxidative phosphorylation_Homo sapiens_hsa001903.10277743
5Parkinsons disease_Homo sapiens_hsa050122.66766513
6Alzheimers disease_Homo sapiens_hsa050102.32911788
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.23669082
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.15663148
9Nicotine addiction_Homo sapiens_hsa050331.97477043
10Ribosome_Homo sapiens_hsa030101.93004257
11Taste transduction_Homo sapiens_hsa047421.88880771
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.88564057
13GABAergic synapse_Homo sapiens_hsa047271.78256517
14Huntingtons disease_Homo sapiens_hsa050161.78057103
15Dorso-ventral axis formation_Homo sapiens_hsa043201.75491520
16Cardiac muscle contraction_Homo sapiens_hsa042601.73720839
17Basal transcription factors_Homo sapiens_hsa030221.68752240
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.65051663
19Butanoate metabolism_Homo sapiens_hsa006501.64350533
20Morphine addiction_Homo sapiens_hsa050321.63529563
21Basal cell carcinoma_Homo sapiens_hsa052171.63483107
22RNA degradation_Homo sapiens_hsa030181.62374078
23RNA polymerase_Homo sapiens_hsa030201.42014126
24Cocaine addiction_Homo sapiens_hsa050301.40427809
25Nitrogen metabolism_Homo sapiens_hsa009101.37869080
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36225434
27Olfactory transduction_Homo sapiens_hsa047401.24641039
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23915160
29Insulin secretion_Homo sapiens_hsa049111.23801074
30Hedgehog signaling pathway_Homo sapiens_hsa043401.20478276
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16550487
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11177706
33Vitamin digestion and absorption_Homo sapiens_hsa049771.11132159
34Proteasome_Homo sapiens_hsa030501.09574046
35Tryptophan metabolism_Homo sapiens_hsa003801.09273248
36Linoleic acid metabolism_Homo sapiens_hsa005911.08661839
37Circadian entrainment_Homo sapiens_hsa047131.07312088
38TGF-beta signaling pathway_Homo sapiens_hsa043501.05732912
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04662136
40Phototransduction_Homo sapiens_hsa047441.02867306
41Histidine metabolism_Homo sapiens_hsa003401.00167741
42Gastric acid secretion_Homo sapiens_hsa049710.96100507
43Melanogenesis_Homo sapiens_hsa049160.95695732
44Axon guidance_Homo sapiens_hsa043600.93535902
45Glutamatergic synapse_Homo sapiens_hsa047240.92985682
46Dopaminergic synapse_Homo sapiens_hsa047280.91253036
47Retinol metabolism_Homo sapiens_hsa008300.89982048
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88545562
49Ovarian steroidogenesis_Homo sapiens_hsa049130.86300640
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86292094
51Thyroid hormone synthesis_Homo sapiens_hsa049180.85292122
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.83756754
53Purine metabolism_Homo sapiens_hsa002300.80641055
54Gap junction_Homo sapiens_hsa045400.80309794
55Chemical carcinogenesis_Homo sapiens_hsa052040.79119753
56Cholinergic synapse_Homo sapiens_hsa047250.79001404
57Tyrosine metabolism_Homo sapiens_hsa003500.74510502
58Caffeine metabolism_Homo sapiens_hsa002320.72811964
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72317604
60Ether lipid metabolism_Homo sapiens_hsa005650.71794963
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69600977
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68138763
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67410854
64Oocyte meiosis_Homo sapiens_hsa041140.62408002
65Fatty acid metabolism_Homo sapiens_hsa012120.61943473
66Steroid biosynthesis_Homo sapiens_hsa001000.60879506
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59170960
68Calcium signaling pathway_Homo sapiens_hsa040200.58839974
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58279952
70Wnt signaling pathway_Homo sapiens_hsa043100.57232441
71Arginine biosynthesis_Homo sapiens_hsa002200.52393218
72Estrogen signaling pathway_Homo sapiens_hsa049150.51884308
73Phenylalanine metabolism_Homo sapiens_hsa003600.50805152
74Fanconi anemia pathway_Homo sapiens_hsa034600.50390357
75Circadian rhythm_Homo sapiens_hsa047100.50361903
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50278025
77ABC transporters_Homo sapiens_hsa020100.49884595
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49007152
79Amphetamine addiction_Homo sapiens_hsa050310.48372821
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.46242602
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.45508445
82Bile secretion_Homo sapiens_hsa049760.44283497
83Propanoate metabolism_Homo sapiens_hsa006400.43939433
84Oxytocin signaling pathway_Homo sapiens_hsa049210.43306037
85Starch and sucrose metabolism_Homo sapiens_hsa005000.43014575
86Antigen processing and presentation_Homo sapiens_hsa046120.41154123
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38864080
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38540934
89Rheumatoid arthritis_Homo sapiens_hsa053230.37876365
90Salivary secretion_Homo sapiens_hsa049700.37654616
91Fatty acid degradation_Homo sapiens_hsa000710.37319461
92Regulation of autophagy_Homo sapiens_hsa041400.35835993
93Renin secretion_Homo sapiens_hsa049240.35505472
94Pyrimidine metabolism_Homo sapiens_hsa002400.35200650
95Fat digestion and absorption_Homo sapiens_hsa049750.34932396
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33661069
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33581993
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31506345
99Metabolic pathways_Homo sapiens_hsa011000.30027559
100Sulfur metabolism_Homo sapiens_hsa009200.28343801

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