ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	8.37849844
2	translational termination (GO:0006415)	7.98240534
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	7.37208692
4	sequestering of actin monomers (GO:0042989)	7.27608787
5	cotranslational protein targeting to membrane (GO:0006613)	6.92976089
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.85691632
7	protein targeting to ER (GO:0045047)	6.74041276
8	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.46850498
9	translational elongation (GO:0006414)	6.39633409
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.38507276
11	ATP synthesis coupled proton transport (GO:0015986)	6.38507276
12	cellular protein complex disassembly (GO:0043624)	6.23379248
13	protein localization to endoplasmic reticulum (GO:0070972)	6.20199268
14	ribosomal small subunit assembly (GO:0000028)	6.00320989
15	maturation of SSU-rRNA (GO:0030490)	6.00295929
16	viral life cycle (GO:0019058)	5.84224567
17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.76477044
18	protein complex disassembly (GO:0043241)	5.30703448
19	translational initiation (GO:0006413)	5.10248860
20	macromolecular complex disassembly (GO:0032984)	4.98281171
21	dopaminergic neuron differentiation (GO:0071542)	4.95299351
22	limb bud formation (GO:0060174)	4.86157619
23	protein neddylation (GO:0045116)	4.70692744
24	ribosomal small subunit biogenesis (GO:0042274)	4.69233250
25	midbrain development (GO:0030901)	4.63497522
26	respiratory electron transport chain (GO:0022904)	4.48968217
27	electron transport chain (GO:0022900)	4.47247721
28	protein targeting to membrane (GO:0006612)	4.42437309
29	lateral sprouting from an epithelium (GO:0060601)	4.39821848
30	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.38548049
31	positive regulation of gastrulation (GO:2000543)	4.13865145
32	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.76634165
33	neuronal stem cell maintenance (GO:0097150)	3.75077755
34	inner mitochondrial membrane organization (GO:0007007)	3.69637839
35	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.54384413
36	mRNA catabolic process (GO:0006402)	3.53804944
37	retinal ganglion cell axon guidance (GO:0031290)	3.49601866
38	artery development (GO:0060840)	3.48849188
39	ribosomal large subunit biogenesis (GO:0042273)	3.43529087
40	primitive streak formation (GO:0090009)	3.37154035
41	translation (GO:0006412)	3.33339506
42	presynaptic membrane assembly (GO:0097105)	3.29422340
43	hydrogen ion transmembrane transport (GO:1902600)	3.28832351
44	cGMP biosynthetic process (GO:0006182)	3.25023346
45	positive regulation of synaptic transmission, GABAergic (GO:0032230)	3.18811791
46	regulation of cell-cell adhesion mediated by cadherin (GO:2000047)	3.13531179
47	ATP biosynthetic process (GO:0006754)	3.12799418
48	neuron fate determination (GO:0048664)	3.11668415
49	intraciliary transport (GO:0042073)	3.11534881
50	serotonin receptor signaling pathway (GO:0007210)	3.11050748
51	kidney morphogenesis (GO:0060993)	3.10399177
52	thalamus development (GO:0021794)	3.09702272
53	RNA catabolic process (GO:0006401)	3.07117769
54	microtubule depolymerization (GO:0007019)	3.04616101
55	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.03369975
56	establishment of protein localization to membrane (GO:0090150)	3.01239198
57	regulation of phospholipid biosynthetic process (GO:0071071)	3.01112809
58	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.99450305
59	axonal fasciculation (GO:0007413)	2.99277077
60	chaperone-mediated protein transport (GO:0072321)	2.97749798
61	dorsal/ventral neural tube patterning (GO:0021904)	2.96927007
62	neural tube formation (GO:0001841)	2.95815058
63	presynaptic membrane organization (GO:0097090)	2.88748680
64	urogenital system development (GO:0001655)	2.87237034
65	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.87076669
66	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.85500496
67	DNA damage response, detection of DNA damage (GO:0042769)	2.84637127
68	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.83018247
69	epithelial cilium movement (GO:0003351)	2.82662189
70	somite development (GO:0061053)	2.82193597
71	proton transport (GO:0015992)	2.82017892
72	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.78391847
73	protein complex biogenesis (GO:0070271)	2.75665548
74	determination of left/right symmetry (GO:0007368)	2.74717930
75	hydrogen transport (GO:0006818)	2.74663254
76	spinal cord motor neuron differentiation (GO:0021522)	2.74056086
77	kinetochore assembly (GO:0051382)	2.73423564
78	tachykinin receptor signaling pathway (GO:0007217)	2.72469517
79	spermatid nucleus differentiation (GO:0007289)	2.72187139
80	regulation of development, heterochronic (GO:0040034)	2.69794882
81	somite rostral/caudal axis specification (GO:0032525)	2.67868726
82	CENP-A containing nucleosome assembly (GO:0034080)	2.64993824
83	neurofilament cytoskeleton organization (GO:0060052)	2.64095950
84	chromatin remodeling at centromere (GO:0031055)	2.62491996
85	establishment of protein localization to organelle (GO:0072594)	2.61191976
86	tongue development (GO:0043586)	2.61105890
87	protein targeting (GO:0006605)	2.60489590
88	regulation of timing of cell differentiation (GO:0048505)	2.59495797
89	pyrimidine nucleobase catabolic process (GO:0006208)	2.58434044
90	behavioral defense response (GO:0002209)	2.57438618
91	behavioral fear response (GO:0001662)	2.57438618
92	dendritic spine morphogenesis (GO:0060997)	2.57438414
93	determination of bilateral symmetry (GO:0009855)	2.57354406
94	specification of symmetry (GO:0009799)	2.56724277
95	mesenchymal cell proliferation (GO:0010463)	2.56145216
96	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.55909994
97	NADH dehydrogenase complex assembly (GO:0010257)	2.55909994
98	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.55909994
99	kinetochore organization (GO:0051383)	2.53474139
100	smoothened signaling pathway (GO:0007224)	2.49908964

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.93835700
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.63953513
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.40328899
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.10089306
5	CBX2_27304074_Chip-Seq_ESCs_Mouse	3.09016554
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.87341939
7	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.67505990
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.58834633
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.54995841
10	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.50712593
11	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.46998679
12	FUS_26573619_Chip-Seq_HEK293_Human	2.45765190
13	EWS_26573619_Chip-Seq_HEK293_Human	2.43523818
14	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.43431812
15	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.42946310
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.39779758
17	VDR_22108803_ChIP-Seq_LS180_Human	2.29776634
18	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.29507754
19	ZNF274_21170338_ChIP-Seq_K562_Hela	2.21466726
20	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.13165219
21	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.04530731
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.95901287
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92868524
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.92579808
25	GBX2_23144817_ChIP-Seq_PC3_Human	1.85366341
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.84925409
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.83862568
28	IGF1R_20145208_ChIP-Seq_DFB_Human	1.82117295
29	RNF2_27304074_Chip-Seq_NSC_Mouse	1.73742661
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.70319538
31	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.69112528
32	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.66902733
33	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.65626654
34	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.65566464
35	P300_19829295_ChIP-Seq_ESCs_Human	1.63631147
36	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.63454608
37	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.60386475
38	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.59152534
39	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.58482811
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.53707194
41	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.51861656
42	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50106894
43	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.50106894
44	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.49014328
45	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.47746233
46	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.43310971
47	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.42154765
48	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.41240820
49	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.40231046
50	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37477819
51	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.35884586
52	REST_21632747_ChIP-Seq_MESCs_Mouse	1.33940692
53	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.33861731
54	TTF2_22483619_ChIP-Seq_HELA_Human	1.33275986
55	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.31288881
56	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.31204121
57	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.31204121
58	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.30623078
59	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.29973925
60	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.29399549
61	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.27399666
62	IRF1_19129219_ChIP-ChIP_H3396_Human	1.27309314
63	GATA1_22025678_ChIP-Seq_K562_Human	1.25840154
64	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.24416732
65	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23578328
66	MYC_18940864_ChIP-ChIP_HL60_Human	1.22878878
67	VDR_23849224_ChIP-Seq_CD4+_Human	1.17202716
68	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.16617702
69	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.15410782
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.14228460
71	ER_23166858_ChIP-Seq_MCF-7_Human	1.13666585
72	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.13088517
73	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.12685756
74	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.12353905
75	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.11900964
76	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.08881615
77	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.08345567
78	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.07758101
79	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05895587
80	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05294720
81	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.03426359
82	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.01929841
83	XRN2_22483619_ChIP-Seq_HELA_Human	1.01808566
84	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.00164337
85	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.99966140
86	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.99816562
87	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.97925335
88	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.97496391
89	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.97480539
90	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.96090724
91	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.94958009
92	BCAT_22108803_ChIP-Seq_LS180_Human	0.94405014
93	TP53_22573176_ChIP-Seq_HFKS_Human	0.94173759
94	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.93429990
95	AR_21572438_ChIP-Seq_LNCaP_Human	0.91099086
96	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.90386290
97	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.88539048
98	SMAD4_21799915_ChIP-Seq_A2780_Human	0.87790498
99	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.87237280
100	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.86553102

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000566_synostosis	6.78486911
2	MP0009379_abnormal_foot_pigmentation	6.02044264
3	MP0003136_yellow_coat_color	4.78047759
4	MP0003283_abnormal_digestive_organ	4.03065232
5	MP0000372_irregular_coat_pigmentation	3.55921077
6	MP0010030_abnormal_orbit_morphology	3.30508077
7	MP0002938_white_spotting	3.04492561
8	MP0000537_abnormal_urethra_morphology	3.02314274
9	MP0003315_abnormal_perineum_morphology	2.43044576
10	MP0002234_abnormal_pharynx_morphology	2.33725380
11	MP0003890_abnormal_embryonic-extraembry	2.33168061
12	MP0004142_abnormal_muscle_tone	2.31332958
13	MP0004133_heterotaxia	2.28445827
14	MP0003880_abnormal_central_pattern	2.22381384
15	MP0001529_abnormal_vocalization	2.21816504
16	MP0008961_abnormal_basal_metabolism	2.03284888
17	MP0006276_abnormal_autonomic_nervous	2.03060439
18	MP0003938_abnormal_ear_development	1.95166444
19	MP0002102_abnormal_ear_morphology	1.94325835
20	MP0006292_abnormal_olfactory_placode	1.90391560
21	MP0004742_abnormal_vestibular_system	1.75997959
22	MP0001293_anophthalmia	1.75894667
23	MP0002653_abnormal_ependyma_morphology	1.61628281
24	MP0000778_abnormal_nervous_system	1.61055955
25	MP0002282_abnormal_trachea_morphology	1.58575943
26	MP0006072_abnormal_retinal_apoptosis	1.53532477
27	MP0002277_abnormal_respiratory_mucosa	1.52292449
28	MP0009053_abnormal_anal_canal	1.47886970
29	MP0004885_abnormal_endolymph	1.47673388
30	MP0000631_abnormal_neuroendocrine_gland	1.42230230
31	MP0003119_abnormal_digestive_system	1.37528894
32	MP0000026_abnormal_inner_ear	1.37045304
33	MP0003011_delayed_dark_adaptation	1.36646798
34	MP0005187_abnormal_penis_morphology	1.35254050
35	MP0003937_abnormal_limbs/digits/tail_de	1.35015565
36	MP0001346_abnormal_lacrimal_gland	1.32449270
37	MP0001485_abnormal_pinna_reflex	1.18819269
38	MP0002697_abnormal_eye_size	1.18610462
39	MP0002751_abnormal_autonomic_nervous	1.18285723
40	MP0002638_abnormal_pupillary_reflex	1.18059298
41	MP0001286_abnormal_eye_development	1.14818297
42	MP0005171_absent_coat_pigmentation	1.13683726
43	MP0008789_abnormal_olfactory_epithelium	1.13665256
44	MP0010386_abnormal_urinary_bladder	1.05804896
45	MP0005248_abnormal_Harderian_gland	1.05206336
46	MP0005423_abnormal_somatic_nervous	1.04909018
47	MP0008995_early_reproductive_senescence	1.04843484
48	MP0000579_abnormal_nail_morphology	1.03115293
49	MP0002822_catalepsy	1.02569238
50	MP0000049_abnormal_middle_ear	0.98272536
51	MP0002928_abnormal_bile_duct	0.97938933
52	MP0005499_abnormal_olfactory_system	0.94426001
53	MP0005394_taste/olfaction_phenotype	0.94426001
54	MP0000569_abnormal_digit_pigmentation	0.93365704
55	MP0001486_abnormal_startle_reflex	0.92072905
56	MP0009745_abnormal_behavioral_response	0.91897673
57	MP0003137_abnormal_impulse_conducting	0.90470168
58	MP0005253_abnormal_eye_physiology	0.90404812
59	MP0002184_abnormal_innervation	0.90282646
60	MP0000955_abnormal_spinal_cord	0.89909380
61	MP0005391_vision/eye_phenotype	0.89476311
62	MP0005084_abnormal_gallbladder_morpholo	0.88695511
63	MP0002095_abnormal_skin_pigmentation	0.87281884
64	MP0003959_abnormal_lean_body	0.86037467
65	MP0005551_abnormal_eye_electrophysiolog	0.85751443
66	MP0005377_hearing/vestibular/ear_phenot	0.85626467
67	MP0003878_abnormal_ear_physiology	0.85626467
68	MP0005195_abnormal_posterior_eye	0.84374225
69	MP0002064_seizures	0.83113826
70	MP0002752_abnormal_somatic_nervous	0.82969202
71	MP0004145_abnormal_muscle_electrophysio	0.82453209
72	MP0003121_genomic_imprinting	0.82268052
73	MP0001963_abnormal_hearing_physiology	0.81532756
74	MP0003122_maternal_imprinting	0.81160355
75	MP0002233_abnormal_nose_morphology	0.80825712
76	MP0001299_abnormal_eye_distance/	0.80197268
77	MP0002067_abnormal_sensory_capabilities	0.79508971
78	MP0002092_abnormal_eye_morphology	0.78994426
79	MP0000462_abnormal_digestive_system	0.78268793
80	MP0005408_hypopigmentation	0.78170432
81	MP0002736_abnormal_nociception_after	0.77659943
82	MP0001324_abnormal_eye_pigmentation	0.77222304
83	MP0009697_abnormal_copulation	0.75439360
84	MP0001984_abnormal_olfaction	0.74198809
85	MP0001440_abnormal_grooming_behavior	0.73977208
86	MP0009250_abnormal_appendicular_skeleto	0.72060120
87	MP0002557_abnormal_social/conspecific_i	0.71749449
88	MP0003755_abnormal_palate_morphology	0.70579710
89	MP0001968_abnormal_touch/_nociception	0.69242091
90	MP0002111_abnormal_tail_morphology	0.68983570
91	MP0002272_abnormal_nervous_system	0.65962132
92	MP0002572_abnormal_emotion/affect_behav	0.64890446
93	MP0002109_abnormal_limb_morphology	0.64484106
94	MP0003567_abnormal_fetal_cardiomyocyte	0.58857956
95	MP0008875_abnormal_xenobiotic_pharmacok	0.58536347
96	MP0003861_abnormal_nervous_system	0.58165656
97	MP0009046_muscle_twitch	0.57719473
98	MP0002882_abnormal_neuron_morphology	0.57546957
99	MP0003635_abnormal_synaptic_transmissio	0.56899277
100	MP0003718_maternal_effect	0.55027025

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.98971388
2	Abnormality of cells of the erythroid lineage (HP:0012130)	4.80371509
3	Abnormal number of erythroid precursors (HP:0012131)	4.78424135
4	Septo-optic dysplasia (HP:0100842)	3.80620118
5	Congenital, generalized hypertrichosis (HP:0004540)	3.69781183
6	Macrocytic anemia (HP:0001972)	3.67264760
7	Increased hepatocellular lipid droplets (HP:0006565)	3.65003701
8	3-Methylglutaconic aciduria (HP:0003535)	3.58754449
9	True hermaphroditism (HP:0010459)	3.51091016
10	Pancreatic cysts (HP:0001737)	3.47468586
11	Pancreatic fibrosis (HP:0100732)	3.40627711
12	Lipid accumulation in hepatocytes (HP:0006561)	3.15567465
13	Concave nail (HP:0001598)	3.12664088
14	Partial duplication of the phalanx of hand (HP:0009999)	3.04841757
15	Renal Fanconi syndrome (HP:0001994)	3.00287979
16	Partial duplication of thumb phalanx (HP:0009944)	2.97892539
17	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.95235770
18	Mitochondrial inheritance (HP:0001427)	2.89624387
19	Chronic hepatic failure (HP:0100626)	2.84988691
20	Esophageal atresia (HP:0002032)	2.83619173
21	Humeroradial synostosis (HP:0003041)	2.82152641
22	Synostosis involving the elbow (HP:0003938)	2.82152641
23	Hepatocellular necrosis (HP:0001404)	2.81390745
24	Hepatic necrosis (HP:0002605)	2.71968458
25	Abnormality of midbrain morphology (HP:0002418)	2.71708691
26	Molar tooth sign on MRI (HP:0002419)	2.71708691
27	Absent septum pellucidum (HP:0001331)	2.71565333
28	Pallor (HP:0000980)	2.70028897
29	Sclerocornea (HP:0000647)	2.58377915
30	Acute necrotizing encephalopathy (HP:0006965)	2.57897394
31	Abnormality of the parietal bone (HP:0002696)	2.55500792
32	Generalized aminoaciduria (HP:0002909)	2.51300242
33	Anophthalmia (HP:0000528)	2.51113901
34	Increased CSF lactate (HP:0002490)	2.46643790
35	Maternal diabetes (HP:0009800)	2.44714708
36	Focal motor seizures (HP:0011153)	2.43091537
37	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.41877450
38	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.41877450
39	Anencephaly (HP:0002323)	2.40794892
40	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.40280251
41	Exertional dyspnea (HP:0002875)	2.39847135
42	Small epiphyses (HP:0010585)	2.31882697
43	Nephronophthisis (HP:0000090)	2.31232792
44	Optic nerve hypoplasia (HP:0000609)	2.26244603
45	Abnormal mitochondria in muscle tissue (HP:0008316)	2.23632827
46	Cystic liver disease (HP:0006706)	2.23244982
47	Abnormality of the renal cortex (HP:0011035)	2.22343984
48	Occipital encephalocele (HP:0002085)	2.21527786
49	Abnormality of the labia minora (HP:0012880)	2.20597497
50	Bile duct proliferation (HP:0001408)	2.19343472
51	Abnormal biliary tract physiology (HP:0012439)	2.19343472
52	Duplication of thumb phalanx (HP:0009942)	2.19202891
53	Depressed nasal ridge (HP:0000457)	2.18998216
54	Medial flaring of the eyebrow (HP:0010747)	2.18854888
55	Abnormality of the middle phalanges of the toes (HP:0010183)	2.17505597
56	Abnormal ciliary motility (HP:0012262)	2.16268130
57	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	2.16255187
58	Acute encephalopathy (HP:0006846)	2.14577464
59	Bilateral microphthalmos (HP:0007633)	2.12816885
60	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.12436649
61	Triphalangeal thumb (HP:0001199)	2.10611045
62	Hypoplasia of the pons (HP:0012110)	2.08019711
63	Congenital hepatic fibrosis (HP:0002612)	2.06722315
64	Short 4th metacarpal (HP:0010044)	2.05279292
65	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.05279292
66	Abnormality of the septum pellucidum (HP:0007375)	2.03752108
67	Progressive macrocephaly (HP:0004481)	2.02445648
68	Optic disc pallor (HP:0000543)	1.98756862
69	Respiratory difficulties (HP:0002880)	1.98203723
70	Abnormality of the renal medulla (HP:0100957)	1.97614652
71	Type 2 muscle fiber atrophy (HP:0003554)	1.96591307
72	Limb dystonia (HP:0002451)	1.96295095
73	Abnormal respiratory motile cilium morphology (HP:0005938)	1.95815406
74	Abnormal respiratory epithelium morphology (HP:0012253)	1.95815406
75	Limited elbow extension (HP:0001377)	1.95580917
76	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.95280935
77	Stenosis of the external auditory canal (HP:0000402)	1.95259641
78	Prominent supraorbital ridges (HP:0000336)	1.92986699
79	Duplicated collecting system (HP:0000081)	1.92937879
80	Hypothermia (HP:0002045)	1.92734567
81	Volvulus (HP:0002580)	1.92315849
82	Retinal dysplasia (HP:0007973)	1.92028875
83	Rib fusion (HP:0000902)	1.91396018
84	Nasolacrimal duct obstruction (HP:0000579)	1.90751358
85	Gastrointestinal atresia (HP:0002589)	1.88456333
86	Abnormality of the pons (HP:0007361)	1.87862139
87	Increased intramyocellular lipid droplets (HP:0012240)	1.85699907
88	Postaxial foot polydactyly (HP:0001830)	1.84252751
89	Abnormality of renal resorption (HP:0011038)	1.82783801
90	Abnormality of the lacrimal duct (HP:0011481)	1.79909568
91	Respiratory distress (HP:0002098)	1.79117693
92	Male pseudohermaphroditism (HP:0000037)	1.78989153
93	Degeneration of anterior horn cells (HP:0002398)	1.77744564
94	Abnormality of the anterior horn cell (HP:0006802)	1.77744564
95	Optic nerve coloboma (HP:0000588)	1.77398253
96	Abnormality of the nasolacrimal system (HP:0000614)	1.76701712
97	Renal cortical cysts (HP:0000803)	1.76240566
98	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.75529692
99	Postaxial hand polydactyly (HP:0001162)	1.75478727
100	Holoprosencephaly (HP:0001360)	1.75369238

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHB2	5.54126339
2	PASK	3.92027363
3	VRK2	3.05935990
4	BUB1	2.84354210
5	UHMK1	2.48615061
6	TLK1	2.30341560
7	FGFR2	2.19569363
8	EPHA3	2.17030448
9	TGFBR1	2.11777754
10	ZAK	2.01602300
11	STK16	2.01116492
12	VRK1	1.97587986
13	SRPK1	1.97335072
14	PNCK	1.96580071
15	PRKD3	1.92929532
16	WNK3	1.89547476
17	DYRK2	1.81478867
18	NTRK2	1.80746761
19	EPHA4	1.77548580
20	DYRK3	1.74945072
21	MARK1	1.62481029
22	MAPK13	1.49334992
23	ADRBK2	1.45783407
24	KSR1	1.37175861
25	MAPK15	1.34992736
26	MKNK1	1.33195040
27	TNIK	1.32123004
28	WEE1	1.23723176
29	MAP3K10	1.21254299
30	PRKCG	1.16160135
31	GRK7	1.15493622
32	CDK8	1.08161887
33	BCKDK	1.08145358
34	CDK19	1.04040671
35	STK24	1.02025044
36	MAP3K4	0.99823142
37	MARK3	0.98895424
38	BRSK2	0.97149820
39	NME1	0.96141973
40	TYRO3	0.95410922
41	SIK2	0.93841914
42	RPS6KA4	0.91368424
43	TTK	0.90882387
44	LRRK2	0.89451034
45	CDK3	0.87960106
46	PLK3	0.85487427
47	MAP4K2	0.84578573
48	INSRR	0.84024940
49	MAP2K4	0.83432072
50	ERBB2	0.82827934
51	FGFR1	0.81833810
52	CASK	0.80461613
53	SIK1	0.79357439
54	MKNK2	0.76584614
55	CAMKK2	0.74849102
56	CCNB1	0.74244677
57	PIK3CA	0.74006629
58	MAP2K7	0.73391679
59	PRKCE	0.71906447
60	SGK223	0.71108811
61	SGK494	0.71108811
62	ADRBK1	0.71078110
63	MAP3K12	0.68809967
64	DDR2	0.68600259
65	BMPR1B	0.66998453
66	TAOK3	0.66829999
67	AURKB	0.66151241
68	SIK3	0.61970734
69	CHEK2	0.61595831
70	TAF1	0.61176426
71	PRKCH	0.60378202
72	MINK1	0.56976229
73	OBSCN	0.53635378
74	DYRK1B	0.53217940
75	PLK1	0.52248410
76	NEK2	0.50865193
77	GRK1	0.50453633
78	PKN1	0.50124475
79	CHUK	0.47545149
80	PAK3	0.45054301
81	PRKACB	0.44895258
82	CSNK2A2	0.44008717
83	PRKACA	0.43703767
84	FLT3	0.41837949
85	OXSR1	0.41829265
86	CSNK1A1	0.41763735
87	CSNK2A1	0.40907025
88	STK38L	0.39482075
89	CAMK2A	0.38522566
90	RPS6KA5	0.37308665
91	MAP3K11	0.35476773
92	CSNK1G2	0.34615222
93	CAMK1G	0.34015579
94	PRKG1	0.32267243
95	BRSK1	0.31533664
96	CSNK1G3	0.30935413
97	STK11	0.28593380
98	FRK	0.27832850
99	NUAK1	0.27682336
100	PRKCZ	0.27303290

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.55369410
2	Oxidative phosphorylation_Homo sapiens_hsa00190	5.32866857
3	Parkinsons disease_Homo sapiens_hsa05012	4.41586821
4	Alzheimers disease_Homo sapiens_hsa05010	3.23587269
5	Huntingtons disease_Homo sapiens_hsa05016	3.21551194
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.90365606
7	Cardiac muscle contraction_Homo sapiens_hsa04260	2.79159777
8	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.75064128
9	Proteasome_Homo sapiens_hsa03050	2.62009570
10	Protein export_Homo sapiens_hsa03060	2.57142854
11	Basal cell carcinoma_Homo sapiens_hsa05217	1.87930967
12	Nicotine addiction_Homo sapiens_hsa05033	1.81281058
13	Homologous recombination_Homo sapiens_hsa03440	1.57621221
14	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.55937957
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.52507016
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.48180517
17	RNA polymerase_Homo sapiens_hsa03020	1.45523513
18	Spliceosome_Homo sapiens_hsa03040	1.45127638
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.36943424
20	Mismatch repair_Homo sapiens_hsa03430	1.33541169
21	Basal transcription factors_Homo sapiens_hsa03022	1.32162143
22	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.24624089
23	Butanoate metabolism_Homo sapiens_hsa00650	1.17305144
24	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.14798152
25	Steroid biosynthesis_Homo sapiens_hsa00100	1.11612664
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.10166146
27	Phototransduction_Homo sapiens_hsa04744	1.07285408
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.06291611
29	Histidine metabolism_Homo sapiens_hsa00340	1.05797604
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.04887685
31	Taste transduction_Homo sapiens_hsa04742	1.04034670
32	Cocaine addiction_Homo sapiens_hsa05030	1.00785504
33	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.00541434
34	RNA degradation_Homo sapiens_hsa03018	0.98864001
35	Axon guidance_Homo sapiens_hsa04360	0.84023441
36	Nucleotide excision repair_Homo sapiens_hsa03420	0.82667604
37	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.82378960
38	Glutamatergic synapse_Homo sapiens_hsa04724	0.80122432
39	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.78369829
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.77869181
41	DNA replication_Homo sapiens_hsa03030	0.73493396
42	Propanoate metabolism_Homo sapiens_hsa00640	0.71701883
43	Gap junction_Homo sapiens_hsa04540	0.70977798
44	Serotonergic synapse_Homo sapiens_hsa04726	0.68972065
45	Circadian rhythm_Homo sapiens_hsa04710	0.67628882
46	Linoleic acid metabolism_Homo sapiens_hsa00591	0.66550814
47	Cell cycle_Homo sapiens_hsa04110	0.65263981
48	Collecting duct acid secretion_Homo sapiens_hsa04966	0.64355156
49	GABAergic synapse_Homo sapiens_hsa04727	0.62907095
50	Olfactory transduction_Homo sapiens_hsa04740	0.61238067
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.61167432
52	Caffeine metabolism_Homo sapiens_hsa00232	0.58158632
53	Tyrosine metabolism_Homo sapiens_hsa00350	0.57804083
54	Selenocompound metabolism_Homo sapiens_hsa00450	0.57492526
55	Wnt signaling pathway_Homo sapiens_hsa04310	0.56803426
56	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.56090903
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.55598930
58	Metabolic pathways_Homo sapiens_hsa01100	0.55209882
59	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.54643361
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.54217418
61	Tryptophan metabolism_Homo sapiens_hsa00380	0.54027034
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.51005760
63	Purine metabolism_Homo sapiens_hsa00230	0.50587108
64	Alcoholism_Homo sapiens_hsa05034	0.49327355
65	Hippo signaling pathway_Homo sapiens_hsa04390	0.49040044
66	RNA transport_Homo sapiens_hsa03013	0.48753583
67	Non-homologous end-joining_Homo sapiens_hsa03450	0.47269732
68	Circadian entrainment_Homo sapiens_hsa04713	0.46569997
69	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.45835077
70	Amphetamine addiction_Homo sapiens_hsa05031	0.43007498
71	Retinol metabolism_Homo sapiens_hsa00830	0.42313506
72	Cholinergic synapse_Homo sapiens_hsa04725	0.41500278
73	beta-Alanine metabolism_Homo sapiens_hsa00410	0.40901269
74	Pyrimidine metabolism_Homo sapiens_hsa00240	0.40596760
75	Phenylalanine metabolism_Homo sapiens_hsa00360	0.40431731
76	Morphine addiction_Homo sapiens_hsa05032	0.38880733
77	Folate biosynthesis_Homo sapiens_hsa00790	0.38259614
78	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.37420943
79	Melanogenesis_Homo sapiens_hsa04916	0.37302898
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.37084572
81	Mineral absorption_Homo sapiens_hsa04978	0.34924924
82	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.33932153
83	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.33784255
84	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.33616623
85	Oocyte meiosis_Homo sapiens_hsa04114	0.32295135
86	Calcium signaling pathway_Homo sapiens_hsa04020	0.31970075
87	Glutathione metabolism_Homo sapiens_hsa00480	0.30646737
88	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.29223747
89	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.29105236
90	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.28284974
91	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.27473912
92	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.25749427
93	Peroxisome_Homo sapiens_hsa04146	0.25355795
94	Dopaminergic synapse_Homo sapiens_hsa04728	0.25107557
95	Notch signaling pathway_Homo sapiens_hsa04330	0.24896299
96	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.24648256
97	Regulation of autophagy_Homo sapiens_hsa04140	0.23401241
98	Glycerolipid metabolism_Homo sapiens_hsa00561	0.22326138
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.20238734
100	Base excision repair_Homo sapiens_hsa03410	0.19649746

ARL6IP1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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