ARL6IP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.58232790
2DNA deamination (GO:0045006)6.34698297
3viral transcription (GO:0019083)6.19602293
4translational termination (GO:0006415)6.00560595
5translational elongation (GO:0006414)5.48308982
6ribosomal small subunit biogenesis (GO:0042274)5.27069687
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.26753709
8cotranslational protein targeting to membrane (GO:0006613)5.13662670
9protein targeting to ER (GO:0045047)5.12931879
10formation of translation preinitiation complex (GO:0001731)5.03956910
11translational initiation (GO:0006413)4.99184323
12maturation of SSU-rRNA (GO:0030490)4.94940445
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.84699463
14protein localization to endoplasmic reticulum (GO:0070972)4.84550120
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.83734597
16ribosomal large subunit biogenesis (GO:0042273)4.79669528
17viral life cycle (GO:0019058)4.74839733
18cellular protein complex disassembly (GO:0043624)4.70286477
19DNA strand elongation involved in DNA replication (GO:0006271)4.37767511
20telomere maintenance via semi-conservative replication (GO:0032201)4.29486474
21protein complex disassembly (GO:0043241)4.24848769
22ribonucleoprotein complex biogenesis (GO:0022613)4.23536867
23translation (GO:0006412)4.18533403
24negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.18301300
25DNA strand elongation (GO:0022616)4.11740777
26macromolecular complex disassembly (GO:0032984)4.07430320
27GDP-mannose metabolic process (GO:0019673)4.00570565
28negative regulation of erythrocyte differentiation (GO:0045647)3.99092139
29protein maturation by protein folding (GO:0022417)3.97952068
30proteasome assembly (GO:0043248)3.81203804
31DNA replication initiation (GO:0006270)3.75015477
32nuclear-transcribed mRNA catabolic process (GO:0000956)3.74029872
33ribosome biogenesis (GO:0042254)3.72968869
34DNA unwinding involved in DNA replication (GO:0006268)3.65198833
35pseudouridine synthesis (GO:0001522)3.64398850
36UV protection (GO:0009650)3.62430236
37deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.62382609
38telomere maintenance via recombination (GO:0000722)3.59036827
39DNA replication checkpoint (GO:0000076)3.55224288
40rRNA processing (GO:0006364)3.54668353
41pinocytosis (GO:0006907)3.53971928
42mature B cell differentiation involved in immune response (GO:0002313)3.52383346
43mRNA catabolic process (GO:0006402)3.52295350
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.50385803
45cellular component biogenesis (GO:0044085)3.49675125
46spliceosomal snRNP assembly (GO:0000387)3.49362232
47RNA catabolic process (GO:0006401)3.44986309
48rRNA metabolic process (GO:0016072)3.43730878
49mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.41576533
50Arp2/3 complex-mediated actin nucleation (GO:0034314)3.40803249
51folic acid-containing compound biosynthetic process (GO:0009396)3.40606523
52establishment of integrated proviral latency (GO:0075713)3.37587495
53nucleobase biosynthetic process (GO:0046112)3.34868841
54protein targeting to membrane (GO:0006612)3.33891423
55barbed-end actin filament capping (GO:0051016)3.30417771
56energy coupled proton transport, down electrochemical gradient (GO:0015985)3.30285919
57ATP synthesis coupled proton transport (GO:0015986)3.30285919
58mitotic recombination (GO:0006312)3.26897909
59telomere maintenance via telomere lengthening (GO:0010833)3.24539241
60pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.24100630
61purine deoxyribonucleotide catabolic process (GO:0009155)3.23583738
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.22505955
63negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.22395386
64negative regulation of ligase activity (GO:0051352)3.22395386
65positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.21984417
66regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.20752325
67positive thymic T cell selection (GO:0045059)3.20497467
68NIK/NF-kappaB signaling (GO:0038061)3.18435081
69protein localization to kinetochore (GO:0034501)3.15657571
70purine nucleobase biosynthetic process (GO:0009113)3.14584681
71regulation of mitochondrial translation (GO:0070129)3.14145108
72mannose metabolic process (GO:0006013)3.12430358
73nucleotide-excision repair, DNA gap filling (GO:0006297)3.11178470
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10916071
75DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.10246868
76transcription elongation from RNA polymerase III promoter (GO:0006385)3.09890463
77termination of RNA polymerase III transcription (GO:0006386)3.09890463
78nucleobase-containing small molecule interconversion (GO:0015949)3.09062238
79NADH metabolic process (GO:0006734)3.07574265
80immunoglobulin mediated immune response (GO:0016064)3.07466330
81viral mRNA export from host cell nucleus (GO:0046784)3.06948097
82protein retention in ER lumen (GO:0006621)3.06012985
832-deoxyribonucleotide biosynthetic process (GO:0009265)3.05017972
84deoxyribose phosphate biosynthetic process (GO:0046385)3.05017972
85negative regulation of RNA splicing (GO:0033119)3.04831982
86signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.03308082
87intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.03308082
88oxidative phosphorylation (GO:0006119)3.02087282
89deoxyribonucleotide catabolic process (GO:0009264)3.01465388
90nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01116785
91signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.99808815
92signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.99808815
93signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.99808815
94pentose-phosphate shunt (GO:0006098)2.97643236
95pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.95899314
96negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.95723632
97regulation of superoxide anion generation (GO:0032928)2.94710990
98signal transduction involved in DNA damage checkpoint (GO:0072422)2.94599880
99signal transduction involved in DNA integrity checkpoint (GO:0072401)2.94599880
100nucleotide salvage (GO:0043173)2.93953185
101antigen processing and presentation of endogenous antigen (GO:0019883)2.93834205
102negative regulation of cell size (GO:0045792)2.93295508
103regulation of necrotic cell death (GO:0010939)2.92806762
104regulation of cellular amino acid metabolic process (GO:0006521)2.92689237
105ribosome assembly (GO:0042255)2.92264274
106antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.92243621
107positive regulation of B cell differentiation (GO:0045579)2.91577809
108signal transduction involved in cell cycle checkpoint (GO:0072395)2.90239691
109nucleoside diphosphate biosynthetic process (GO:0009133)2.87731067
110establishment of protein localization to mitochondrial membrane (GO:0090151)2.86821359
111rRNA modification (GO:0000154)2.86816289
112deoxyribose phosphate catabolic process (GO:0046386)2.86336056
113transcription-coupled nucleotide-excision repair (GO:0006283)2.85979102
114spliceosomal complex assembly (GO:0000245)2.85639361
115pteridine-containing compound biosynthetic process (GO:0042559)2.85384811
116guanosine-containing compound biosynthetic process (GO:1901070)2.84907235
117termination of RNA polymerase II transcription (GO:0006369)2.84892338
118positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.84787754
119response to peptidoglycan (GO:0032494)2.84493228
120negative regulation of B cell apoptotic process (GO:0002903)2.83398185
121mitotic metaphase plate congression (GO:0007080)2.83218869
122metallo-sulfur cluster assembly (GO:0031163)2.82980726
123iron-sulfur cluster assembly (GO:0016226)2.82980726
124UTP biosynthetic process (GO:0006228)2.82456477
125IMP biosynthetic process (GO:0006188)2.82437984
126CENP-A containing nucleosome assembly (GO:0034080)2.81653320
127chromatin remodeling at centromere (GO:0031055)2.81543171
128establishment of protein localization to mitochondrion (GO:0072655)2.81125576
129regulation of mammary gland epithelial cell proliferation (GO:0033599)2.80674977
130protein targeting to mitochondrion (GO:0006626)2.79951220
131pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.77991195
132maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.73524001
133glucose catabolic process (GO:0006007)2.70180676
134pyrimidine nucleotide catabolic process (GO:0006244)2.68601640
135COPI coating of Golgi vesicle (GO:0048205)2.65567867
136Golgi transport vesicle coating (GO:0048200)2.65567867
137proline biosynthetic process (GO:0006561)2.65496771
138positive regulation of gamma-delta T cell activation (GO:0046645)2.64323073
139negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.64303284
140negative regulation of myeloid cell apoptotic process (GO:0033033)2.57717399
141pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.57322053
142antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.55416464
143regulation of mitochondrial membrane potential (GO:0051881)2.53509595
144negative regulation of necroptotic process (GO:0060546)2.53111539
145regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.52203146
146purine nucleotide salvage (GO:0032261)2.50427376
147modulation by virus of host process (GO:0019054)2.49948834
148modulation by symbiont of host cellular process (GO:0044068)2.48540703
1492-deoxyribonucleotide metabolic process (GO:0009394)2.45837533
150thymic T cell selection (GO:0045061)2.44268470
151actin nucleation (GO:0045010)2.42835135
152positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.41387892
1533-UTR-mediated mRNA stabilization (GO:0070935)2.39226328
154antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.38434341
155mature B cell differentiation (GO:0002335)2.37711791
156purine deoxyribonucleotide metabolic process (GO:0009151)2.36506361
157endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.35158250
158deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.33945473
159NADPH regeneration (GO:0006740)2.33747741
160positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.32729265
161negative regulation of phagocytosis (GO:0050765)2.32611939
162pyrimidine-containing compound salvage (GO:0008655)2.32513986
163pyrimidine nucleoside salvage (GO:0043097)2.32513986
164positive regulation of antigen processing and presentation (GO:0002579)2.30920304
165activation of MAPKKK activity (GO:0000185)2.30582203
166regulation of monocyte differentiation (GO:0045655)2.29849356
167deoxyribose phosphate metabolic process (GO:0019692)2.28674044
168mucosal-associated lymphoid tissue development (GO:0048537)2.28642688
169Peyers patch development (GO:0048541)2.28642688
170tricarboxylic acid metabolic process (GO:0072350)2.27381900
171negative regulation of necrotic cell death (GO:0060547)2.24718179
172detection of bacterium (GO:0016045)2.23673120
173response to interferon-beta (GO:0035456)2.23473239
174regulation of dendritic cell antigen processing and presentation (GO:0002604)2.21543224
175prostanoid biosynthetic process (GO:0046457)2.20611121
176prostaglandin biosynthetic process (GO:0001516)2.20611121
177apoptotic process involved in morphogenesis (GO:0060561)2.19593398
178oxaloacetate metabolic process (GO:0006107)2.19318106

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.37882044
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.37622880
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.30868513
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.09046845
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.07136980
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.05867513
7MYC_18358816_ChIP-ChIP_MESCs_Mouse3.02768059
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.02673871
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.01409374
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.99683442
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86118644
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.74613917
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.72656154
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.68460471
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.61504937
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.60484706
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.56728482
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56174581
19LXR_22292898_ChIP-Seq_THP-1_Human2.50936639
20XRN2_22483619_ChIP-Seq_HELA_Human2.49910431
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.43676829
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.41920375
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.20656907
24VDR_23849224_ChIP-Seq_CD4+_Human2.16895626
25DCP1A_22483619_ChIP-Seq_HELA_Human2.15343451
26* ELK3_25401928_ChIP-Seq_HUVEC_Human2.13045470
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07873594
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.07284267
29FOXP3_21729870_ChIP-Seq_TREG_Human2.05910567
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04832954
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03030302
32RARG_19884340_ChIP-ChIP_MEFs_Mouse2.02412595
33NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02055752
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.00941345
35GABP_19822575_ChIP-Seq_HepG2_Human2.00769909
36MYC_22102868_ChIP-Seq_BL_Human1.98210902
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.96183550
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.91764736
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89574651
40TTF2_22483619_ChIP-Seq_HELA_Human1.84677292
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.84590705
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.81424379
43VDR_24763502_ChIP-Seq_THP-1_Human1.78737967
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76528390
45CIITA_25753668_ChIP-Seq_RAJI_Human1.72319811
46* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70695747
47VDR_21846776_ChIP-Seq_THP-1_Human1.68635274
48RACK7_27058665_Chip-Seq_MCF-7_Human1.67833489
49* P68_20966046_ChIP-Seq_HELA_Human1.67227742
50ELF1_20517297_ChIP-Seq_JURKAT_Human1.64474492
51* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62769399
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61637109
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.57567765
54KDM2B_26808549_Chip-Seq_DND41_Human1.56724605
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54563751
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54044945
57BCL6_27268052_Chip-Seq_Bcells_Human1.52155648
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50569424
59ZNF263_19887448_ChIP-Seq_K562_Human1.50536799
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50098489
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.49266045
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47829626
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45480178
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44493500
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44448836
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44421330
67CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.44344490
68TCF7_22412390_ChIP-Seq_EML_Mouse1.42838188
69BCOR_27268052_Chip-Seq_Bcells_Human1.42316894
70* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.42138605
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41085941
72* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40524140
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.40460716
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36789674
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36143216
76* KDM5A_27292631_Chip-Seq_BREAST_Human1.35684737
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34532592
78MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.33760006
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33402474
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.32243395
81ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.31270024
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30693815
83CTCF_26484167_Chip-Seq_Bcells_Mouse1.29546810
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29432309
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29093746
86ELK1_19687146_ChIP-ChIP_HELA_Human1.28972164
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28617360
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27304087
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27146606
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25580042
91PU.1_20513432_ChIP-Seq_Bcells_Mouse1.24669441
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21654332
93BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21593013
94TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21346152
95STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20900644
96SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20137433
97SMC4_20622854_ChIP-Seq_HELA_Human1.19176873
98YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19005165
99AR_21909140_ChIP-Seq_LNCAP_Human1.18119880
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15997352
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15139679
102SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14803382
103RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13896347
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13286543
105E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13196023
106* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12693620
107* SPI1_23547873_ChIP-Seq_NB4_Human1.12582254
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12471412
109KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11783992
110ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11401335
111* NCOR1_26117541_ChIP-Seq_K562_Human1.10454615
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10327861
113NOTCH1_21737748_ChIP-Seq_TLL_Human1.09957412
114* CTCF_21964334_Chip-Seq_Bcells_Human1.09766180
115PHF8_20622854_ChIP-Seq_HELA_Human1.08975544
116CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08929445
117TFEB_21752829_ChIP-Seq_HELA_Human1.08723030
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08699301
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08665031
120TP63_17297297_ChIP-ChIP_HaCaT_Human1.07862886
121SA1_27219007_Chip-Seq_Bcells_Human1.05422591
122E2F1_20622854_ChIP-Seq_HELA_Human1.05209110
123SCL_19346495_ChIP-Seq_HPC-7_Human1.04719055
124CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04075131
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03793658
126EGR1_19374776_ChIP-ChIP_THP-1_Human1.03787650
127PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03526517
128SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03354549
129* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03123928
130NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02399038
131CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02264239
132TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00576930
133ETS1_21867929_ChIP-Seq_TH2_Mouse1.00034804
134POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99848424
135* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99466684
136GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97010225
137* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96730124
138MYC_18940864_ChIP-ChIP_HL60_Human0.96474648
139SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95478333
140SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95348408
141* FOXP1_21924763_ChIP-Seq_HESCs_Human0.95035014
142ELK1_22589737_ChIP-Seq_MCF10A_Human0.93631797
143KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92632894
144MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91662333
145CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90946032
146OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88986831
147* MAF_26560356_Chip-Seq_TH2_Human0.88415585
148NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87927313
149YY1_22570637_ChIP-Seq_MALME-3M_Human0.87916068
150TET1_21451524_ChIP-Seq_MESCs_Mouse0.87635008
151CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87182277
152CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85562049
153UTX_26944678_Chip-Seq_JUKART_Human0.85363640
154MAF_26560356_Chip-Seq_TH1_Human0.84029978

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.30713496
2MP0004957_abnormal_blastocyst_morpholog4.46591926
3MP0005058_abnormal_lysosome_morphology4.02456679
4MP0003111_abnormal_nucleus_morphology3.61978836
5MP0010094_abnormal_chromosome_stability3.60174297
6MP0005451_abnormal_body_composition3.58561303
7MP0003077_abnormal_cell_cycle3.57008275
8MP0002396_abnormal_hematopoietic_system3.02741684
9MP0008058_abnormal_DNA_repair2.60909622
10MP0008057_abnormal_DNA_replication2.55334899
11MP0003303_peritoneal_inflammation2.41895069
12MP0008932_abnormal_embryonic_tissue2.38349487
13MP0003806_abnormal_nucleotide_metabolis2.32650097
14MP0008007_abnormal_cellular_replicative2.26462172
15MP0006036_abnormal_mitochondrial_physio2.25097462
16MP0003191_abnormal_cellular_cholesterol2.21661495
17MP0000490_abnormal_crypts_of2.21533047
18MP0003172_abnormal_lysosome_physiology2.11182751
19MP0001730_embryonic_growth_arrest2.09381514
20MP0009333_abnormal_splenocyte_physiolog2.09138636
21MP0003186_abnormal_redox_activity1.99233057
22MP0009379_abnormal_foot_pigmentation1.98488865
23MP0002148_abnormal_hypersensitivity_rea1.93928856
24MP0003075_altered_response_to1.92456985
25MP0000350_abnormal_cell_proliferation1.86259716
26MP0004808_abnormal_hematopoietic_stem1.85536235
27MP0003763_abnormal_thymus_physiology1.85272967
28MP0005397_hematopoietic_system_phenotyp1.84394502
29MP0001545_abnormal_hematopoietic_system1.84394502
30MP0008260_abnormal_autophagy1.79448389
31MP0000313_abnormal_cell_death1.79212665
32MP0002419_abnormal_innate_immunity1.79004372
33MP0005387_immune_system_phenotype1.74880700
34MP0001790_abnormal_immune_system1.74880700
35MP0003123_paternal_imprinting1.71613484
36MP0006035_abnormal_mitochondrial_morpho1.69347283
37MP0002398_abnormal_bone_marrow1.65945353
38MP0004510_myositis1.62476265
39MP0000685_abnormal_immune_system1.61418975
40MP0001849_ear_inflammation1.60451704
41MP0002019_abnormal_tumor_incidence1.59993440
42MP0000689_abnormal_spleen_morphology1.57411725
43MP0010030_abnormal_orbit_morphology1.57313097
44MP0002722_abnormal_immune_system1.56279654
45MP0000703_abnormal_thymus_morphology1.54644135
46MP0001697_abnormal_embryo_size1.53156438
47MP0002080_prenatal_lethality1.52311312
48MP0005166_decreased_susceptibility_to1.50529712
49MP0000358_abnormal_cell_content/1.50376755
50MP0000678_abnormal_parathyroid_gland1.45551068
51MP0000681_abnormal_thyroid_gland1.45028775
52MP0003786_premature_aging1.44931719
53MP0002132_abnormal_respiratory_system1.44369210
54MP0003705_abnormal_hypodermis_morpholog1.42084925
55MP0001853_heart_inflammation1.40845220
56MP0004858_abnormal_nervous_system1.38120615
57MP0002429_abnormal_blood_cell1.34828213
58MP0000343_altered_response_to1.32371979
59MP0002877_abnormal_melanocyte_morpholog1.32002633
60MP0004185_abnormal_adipocyte_glucose1.31798570
61MP0005083_abnormal_biliary_tract1.31487886
62MP0005165_increased_susceptibility_to1.29216625
63MP0006082_CNS_inflammation1.28763473
64MP0001533_abnormal_skeleton_physiology1.27702252
65MP0005380_embryogenesis_phenotype1.26958961
66MP0001672_abnormal_embryogenesis/_devel1.26958961
67MP0000465_gastrointestinal_hemorrhage1.26644191
68MP0005666_abnormal_adipose_tissue1.24397001
69MP0004947_skin_inflammation1.23756822
70MP0006292_abnormal_olfactory_placode1.23192309
71MP0001845_abnormal_inflammatory_respons1.22710751
72MP0000716_abnormal_immune_system1.22323626
73MP0005330_cardiomyopathy1.20540995
74MP0003567_abnormal_fetal_cardiomyocyte1.20289116
75MP0003984_embryonic_growth_retardation1.17861519
76MP0001835_abnormal_antigen_presentation1.17722899
77MP0000858_altered_metastatic_potential1.17305437
78MP0005670_abnormal_white_adipose1.16833089
79MP0003718_maternal_effect1.15133882
80MP0003300_gastrointestinal_ulcer1.14522025
81MP0002088_abnormal_embryonic_growth/wei1.14419745
82MP0009840_abnormal_foam_cell1.14038753
83MP0000751_myopathy1.10459346
84MP0005375_adipose_tissue_phenotype1.09803329
85MP0003119_abnormal_digestive_system1.09205184
86MP0002653_abnormal_ependyma_morphology1.09112020
87MP0000747_muscle_weakness1.08884495
88MP0005075_abnormal_melanosome_morpholog1.08551907
89MP0002139_abnormal_hepatobiliary_system1.07996571
90MP0003646_muscle_fatigue1.07684544
91MP0002085_abnormal_embryonic_tissue1.06530798
92MP0004133_heterotaxia1.05773634
93MP0001800_abnormal_humoral_immune1.05373773
94MP0010352_gastrointestinal_tract_polyps1.04659524
95MP0003656_abnormal_erythrocyte_physiolo1.04341225
96MP0000003_abnormal_adipose_tissue1.04325021
97MP0009278_abnormal_bone_marrow1.03904468
98MP0002420_abnormal_adaptive_immunity1.02867347
99MP0003724_increased_susceptibility_to1.02173217
100MP0002086_abnormal_extraembryonic_tissu1.00825590
101MP0001819_abnormal_immune_cell1.00776054
102MP0002405_respiratory_system_inflammati0.99063406
103MP0000759_abnormal_skeletal_muscle0.98296899
104MP0001764_abnormal_homeostasis0.98112797
105MP0005025_abnormal_response_to0.97915981
106MP0003436_decreased_susceptibility_to0.97831445
107MP0000604_amyloidosis0.95906854
108MP0002998_abnormal_bone_remodeling0.93999862
109MP0005360_urolithiasis0.93984668
110MP0008877_abnormal_DNA_methylation0.93756010
111MP0005266_abnormal_metabolism0.93068665
112MP0000750_abnormal_muscle_regeneration0.92583371
113MP0003453_abnormal_keratinocyte_physiol0.92077959
114MP0003329_amyloid_beta_deposits0.91833533
115MP0009785_altered_susceptibility_to0.91640351
116MP0002723_abnormal_immune_serum0.91247019
117MP0005584_abnormal_enzyme/coenzyme_acti0.90432239
118MP0002452_abnormal_antigen_presenting0.89826730
119MP0005501_abnormal_skin_physiology0.89621427
120MP0002084_abnormal_developmental_patter0.88864910
121MP0005174_abnormal_tail_pigmentation0.88696835
122MP0003221_abnormal_cardiomyocyte_apopto0.86759083
123MP0006054_spinal_hemorrhage0.85127490
124MP0005220_abnormal_exocrine_pancreas0.82650535
125MP0002269_muscular_atrophy0.82633096
126MP0005319_abnormal_enzyme/_coenzyme0.81557896
127MP0004197_abnormal_fetal_growth/weight/0.80757777
128MP0009764_decreased_sensitivity_to0.80175555
129MP0003279_aneurysm0.78911643
130MP0001661_extended_life_span0.78728684
131MP0005671_abnormal_response_to0.78183418
132MP0010155_abnormal_intestine_physiology0.77951722
133MP0010307_abnormal_tumor_latency0.77777169
134MP0009643_abnormal_urine_homeostasis0.77711274
135MP0000598_abnormal_liver_morphology0.76922275
136MP0004233_abnormal_muscle_weight0.75226463
137MP0004087_abnormal_muscle_fiber0.73670741
138MP0000477_abnormal_intestine_morphology0.73655451
139MP0009672_abnormal_birth_weight0.73630173
140MP0002166_altered_tumor_susceptibility0.72683430
141MP0008874_decreased_physiological_sensi0.72647531
142MP0002160_abnormal_reproductive_system0.72308719
143MP0005384_cellular_phenotype0.72083284
144MP0002933_joint_inflammation0.70524958
145MP0009763_increased_sensitivity_to0.70466977
146MP0008469_abnormal_protein_level0.69223783
147MP0002796_impaired_skin_barrier0.68907094
148MP0003866_abnormal_defecation0.68341970
149MP0005023_abnormal_wound_healing0.66794399
150MP0005000_abnormal_immune_tolerance0.64815587
151MP0001348_abnormal_lacrimal_gland0.64788388
152MP0002751_abnormal_autonomic_nervous0.63527765
153MP0005464_abnormal_platelet_physiology0.63193386
154MP0001145_abnormal_male_reproductive0.62981148
155MP0001873_stomach_inflammation0.62673716

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.45272683
2Abnormal number of erythroid precursors (HP:0012131)5.84983609
3Reticulocytopenia (HP:0001896)5.12392338
4Macrocytic anemia (HP:0001972)4.12945326
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.99494277
6Decreased activity of mitochondrial respiratory chain (HP:0008972)3.99494277
7Pallor (HP:0000980)3.89899580
8Aplastic anemia (HP:0001915)3.83021909
9Hepatocellular necrosis (HP:0001404)3.60201800
10Mitochondrial inheritance (HP:0001427)3.57159095
11Thrombocytosis (HP:0001894)3.48457934
12Centrally nucleated skeletal muscle fibers (HP:0003687)3.45889188
13Acute necrotizing encephalopathy (HP:0006965)3.41012379
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.34043176
15Abnormality of liposaccharide metabolism (HP:0010968)3.33104499
16Abnormality of glycosphingolipid metabolism (HP:0004343)3.33104499
17Abnormality of glycolipid metabolism (HP:0010969)3.33104499
18Hepatic necrosis (HP:0002605)3.30179967
19Increased CSF lactate (HP:0002490)3.28837737
20Microretrognathia (HP:0000308)3.28121147
21Abnormal mitochondria in muscle tissue (HP:0008316)3.27389547
22Aplasia/Hypoplasia of the sacrum (HP:0008517)3.22391470
23Vertebral compression fractures (HP:0002953)3.22274375
24Increased serum lactate (HP:0002151)3.19525561
25Birth length less than 3rd percentile (HP:0003561)3.18476223
26Cellulitis (HP:0100658)3.17623460
27Oral leukoplakia (HP:0002745)3.12728810
28Increased intramyocellular lipid droplets (HP:0012240)3.12096732
29Agammaglobulinemia (HP:0004432)3.06770880
30Increased hepatocellular lipid droplets (HP:0006565)3.03863214
31Exertional dyspnea (HP:0002875)3.01842191
32Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.95456139
33Obstructive lung disease (HP:0006536)2.94598514
34Chronic obstructive pulmonary disease (HP:0006510)2.94598514
35Trismus (HP:0000211)2.94507970
36Abnormality of the anterior horn cell (HP:0006802)2.93584514
37Degeneration of anterior horn cells (HP:0002398)2.93584514
38Acute encephalopathy (HP:0006846)2.92597957
39Systemic lupus erythematosus (HP:0002725)2.87053163
40Lipid accumulation in hepatocytes (HP:0006561)2.86974441
41Increased muscle lipid content (HP:0009058)2.85180530
42Eczematoid dermatitis (HP:0000976)2.84882471
43Multiple enchondromatosis (HP:0005701)2.82005797
44Myopathic facies (HP:0002058)2.79857086
45Distal lower limb muscle weakness (HP:0009053)2.79383806
46Exercise-induced myalgia (HP:0003738)2.75123755
47Dysostosis multiplex (HP:0000943)2.74928349
48Breast hypoplasia (HP:0003187)2.72100551
49Absent thumb (HP:0009777)2.71744121
50Colitis (HP:0002583)2.70717924
51Selective tooth agenesis (HP:0001592)2.70500406
52Lactic acidosis (HP:0003128)2.67287999
53Progressive muscle weakness (HP:0003323)2.64141753
54Exercise intolerance (HP:0003546)2.61523038
55Abnormality of the heme biosynthetic pathway (HP:0010472)2.59284828
56Microvesicular hepatic steatosis (HP:0001414)2.58343154
57Mediastinal lymphadenopathy (HP:0100721)2.57050093
58Hepatosplenomegaly (HP:0001433)2.54686977
59Achilles tendon contracture (HP:0001771)2.53284369
60Hypertensive crisis (HP:0100735)2.52625176
61Pancytopenia (HP:0001876)2.51689398
62IgM deficiency (HP:0002850)2.48450635
63Increased serum ferritin (HP:0003281)2.47330182
64Progressive macrocephaly (HP:0004481)2.44444070
65Rough bone trabeculation (HP:0100670)2.44428086
66Respiratory difficulties (HP:0002880)2.44406006
67Abnormality of reticulocytes (HP:0004312)2.43568511
68Abnormality of macrophages (HP:0004311)2.43193547
69Carpal bone hypoplasia (HP:0001498)2.41428387
70Purpura (HP:0000979)2.41064753
71Gastrointestinal inflammation (HP:0004386)2.36795810
72Emotional lability (HP:0000712)2.32975500
73Cerebral hypomyelination (HP:0006808)2.31254021
74Cerebral palsy (HP:0100021)2.31193957
75Polygenic inheritance (HP:0010982)2.30205817
76Poikiloderma (HP:0001029)2.28724928
77Recurrent abscess formation (HP:0002722)2.28583486
7811 pairs of ribs (HP:0000878)2.28254913
79Abnormality of the Achilles tendon (HP:0005109)2.28128595
80Abnormality of skeletal muscle fiber size (HP:0012084)2.25440979
81Increased cerebral lipofuscin (HP:0011813)2.24295693
82Meningitis (HP:0001287)2.22624642
83Poor head control (HP:0002421)2.22621250
84Respiratory failure (HP:0002878)2.22499379
85Muscle stiffness (HP:0003552)2.22314150
86Thoracic kyphosis (HP:0002942)2.21992423
87Aplasia/Hypoplasia of the patella (HP:0006498)2.21430844
88Type I transferrin isoform profile (HP:0003642)2.20364369
89Patellar aplasia (HP:0006443)2.17898826
90Prolonged neonatal jaundice (HP:0006579)2.15920205
91Ragged-red muscle fibers (HP:0003200)2.15161042
92Basal cell carcinoma (HP:0002671)2.15095148
93Cerebral edema (HP:0002181)2.15011016
94Petechiae (HP:0000967)2.13984174
95Recurrent bacterial skin infections (HP:0005406)2.13186096
96Renal Fanconi syndrome (HP:0001994)2.11207159
97J-shaped sella turcica (HP:0002680)2.11047555
98Amyloidosis (HP:0011034)2.09904217
993-Methylglutaconic aciduria (HP:0003535)2.09423052
100Inflammation of the large intestine (HP:0002037)2.09058394
101Recurrent viral infections (HP:0004429)2.08197171
102Progressive neurologic deterioration (HP:0002344)2.05734673
103Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04556541
104Abnormality of polysaccharide metabolism (HP:0011012)2.04556541
105Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04556541
106Bulbar palsy (HP:0001283)2.04401040
107Premature graying of hair (HP:0002216)2.04323880
108Increased variability in muscle fiber diameter (HP:0003557)2.03165895
109Abnormal gallbladder physiology (HP:0012438)2.02496751
110Cholecystitis (HP:0001082)2.02496751
111Hypertriglyceridemia (HP:0002155)2.02432950
112Distal lower limb amyotrophy (HP:0008944)2.01819774
113Premature ovarian failure (HP:0008209)2.01446348
114Axonal loss (HP:0003447)2.01442024
115Increased connective tissue (HP:0009025)2.00882142
116Increased neuronal autofluorescent lipopigment (HP:0002074)2.00317047
117Increased IgE level (HP:0003212)2.00156123
118Elevated erythrocyte sedimentation rate (HP:0003565)2.00081469
119Myoglobinuria (HP:0002913)1.99304718
120Hemorrhage of the eye (HP:0011885)1.99196487
121Abnormal hemoglobin (HP:0011902)1.97974291
122Secondary amenorrhea (HP:0000869)1.97891329
123Squamous cell carcinoma (HP:0002860)1.97253110
124CNS demyelination (HP:0007305)1.94856287
125Colon cancer (HP:0003003)1.94530555
126Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.94164613
127Abnormality of alanine metabolism (HP:0010916)1.93417546
128Hyperalaninemia (HP:0003348)1.93417546
129Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93417546
130Growth hormone excess (HP:0000845)1.93060747
131Reduced antithrombin III activity (HP:0001976)1.92654469
132Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.92366677
133Abnormality of the nasal mucosa (HP:0000433)1.91730057
134Testicular atrophy (HP:0000029)1.91382343
135Urinary glycosaminoglycan excretion (HP:0003541)1.91101421
136Mucopolysacchariduria (HP:0008155)1.91101421
137Acute lymphatic leukemia (HP:0006721)1.89888679
138Panhypogammaglobulinemia (HP:0003139)1.87847317
139Bone marrow hypocellularity (HP:0005528)1.86650277
140Joint stiffness (HP:0001387)1.86509583
141Neoplasm of the pancreas (HP:0002894)1.86189831
142Abnormality of the thoracic spine (HP:0100711)1.85891089
143Recurrent fungal infections (HP:0002841)1.85686326
144Myelodysplasia (HP:0002863)1.84744473
145Atrophy/Degeneration involving motor neurons (HP:0007373)1.83598497
146Abnormality of the preputium (HP:0100587)1.83166132
147Abnormality of iron homeostasis (HP:0011031)1.81848344
148Redundant skin (HP:0001582)1.81804851
149Stridor (HP:0010307)1.81004238
150Abnormality of the ileum (HP:0001549)1.80621413
151Abnormal number of incisors (HP:0011064)1.80400023
152Muscle fiber atrophy (HP:0100295)1.80196777
153Abnormality of complement system (HP:0005339)1.80157867
154Cellular immunodeficiency (HP:0005374)1.79924472
155Upper motor neuron abnormality (HP:0002127)1.78783061
156Gastrointestinal stroma tumor (HP:0100723)1.77904262
157Pustule (HP:0200039)1.76987892
158Hyperacusis (HP:0010780)1.76535772
159Asplenia (HP:0001746)1.76416637
160Angiofibromas (HP:0010615)1.76344692
161Adenoma sebaceum (HP:0009720)1.76344692
162Dicarboxylic aciduria (HP:0003215)1.74536158
163Abnormality of dicarboxylic acid metabolism (HP:0010995)1.74536158
164Slender long bone (HP:0003100)1.73610675
165Increased serum pyruvate (HP:0003542)1.72712683
166Abnormality of glycolysis (HP:0004366)1.72712683
167Recurrent gram-negative bacterial infections (HP:0005420)1.72315418
168Broad distal phalanx of finger (HP:0009836)1.72151004
169Epistaxis (HP:0000421)1.72067054
170Loss of speech (HP:0002371)1.72018831
171Meckel diverticulum (HP:0002245)1.71253950
172Protrusio acetabuli (HP:0003179)1.71096244
173Rhabdomyolysis (HP:0003201)1.69377890
174Vacuolated lymphocytes (HP:0001922)1.68252405
175Myositis (HP:0100614)1.67903862
176Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.67468457
177Muscle fiber inclusion bodies (HP:0100299)1.67419430
178Seborrheic dermatitis (HP:0001051)1.67228339
179Cleft eyelid (HP:0000625)1.67004842
180Abnormality of pyrimidine metabolism (HP:0004353)1.65983457
181Hypoplasia of the radius (HP:0002984)1.64549925
182Abnormality of T cell physiology (HP:0011840)1.64149927
183Hypoplasia of the pons (HP:0012110)1.63537028

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.35376244
2BUB14.27965263
3WEE13.12004627
4EIF2AK12.78861604
5CDC72.53772202
6BCKDK2.50424560
7PRPF4B2.41563750
8TESK22.26095404
9NEK22.23862522
10TLK12.14668520
11SMG12.14552976
12IRAK32.13109129
13MAP3K112.04810472
14MAP3K102.04717716
15CDK192.04514251
16MAP4K11.94316267
17VRK21.89914804
18STK161.86766538
19PIM21.85561092
20SRPK11.74742914
21SCYL21.71316190
22KDR1.70241301
23BLK1.67548796
24DYRK31.67169903
25GRK61.65829598
26EIF2AK31.62995985
27BRSK21.61299583
28RPS6KA41.60586638
29PASK1.58724731
30RIPK41.50702033
31PLK11.49614606
32PKN21.46816653
33VRK11.35282731
34TTN1.34714892
35FLT31.34072026
36NME11.32882695
37MAP2K31.32276868
38CDK71.30863921
39AURKA1.30801371
40MAP3K131.29416043
41PAK41.28934701
42AURKB1.28930176
43RPS6KB21.28844506
44ERN11.26380295
45PLK41.22088148
46MAPKAPK31.21440837
47CCNB11.20315201
48BRSK11.20002375
49MAP3K11.15850008
50TRIB31.15047668
51ZAP701.13040247
52SIK11.11053345
53ACVR1B1.10228706
54FES1.09782719
55LRRK21.07169505
56MAP3K81.06870524
57MKNK11.06555245
58MAP3K31.05905999
59CDK41.05621435
60TTK1.05107024
61LIMK11.04440016
62DAPK11.02834339
63TSSK60.99355965
64ATR0.98887782
65NEK10.98581613
66CDK80.97137093
67ICK0.96121151
68MKNK20.95711656
69KIT0.90569344
70BRAF0.90427273
71RIPK10.90332444
72BTK0.87120051
73EEF2K0.84441275
74CHEK20.82946231
75PIM10.82656701
76CSF1R0.80275369
77ILK0.79859865
78MOS0.78986165
79CSNK2A20.77215287
80PDPK10.75833713
81CSNK2A10.74854181
82MAPK120.74507066
83STK100.73229042
84TNK20.71964764
85TESK10.71690416
86MAPK110.68762011
87JAK30.68083048
88PAK10.67360606
89MAP2K60.64242802
90TEC0.63619868
91EPHA20.62947947
92ARAF0.61008708
93TYK20.59829229
94IKBKB0.57914596
95PRKD30.55847078
96CHEK10.55517483
97STK40.55184872
98AKT20.54823221
99TGFBR10.53240489
100TBK10.52787248
101PRKG20.52712168
102SYK0.52690501
103MAP3K140.52642884
104TAOK20.52359625
105RPS6KA20.52121541
106IKBKE0.51323572
107PLK30.50656838
108CDK20.49806388
109RPS6KA60.49502379
110HIPK20.49003436
111PRKCI0.48598820
112RPS6KC10.48410869
113RPS6KL10.48410869
114CSK0.47905208
115PRKD20.47878880
116CAMKK10.46591641
117PDK10.46420338
118MATK0.45808549
119CDC42BPA0.44794910
120PTK60.43668878
121TGFBR20.43217096
122ABL20.43180440
123BMX0.43074097
124IRAK20.42919835
125MAP3K120.41082713
126DAPK30.40473408
127MYLK0.40172742
128CAMK2G0.40009907
129LYN0.38885955
130RAF10.38856234
131MARK30.36146164
132ITK0.35177218
133HCK0.35172654
134RPS6KA50.34141124
135MAP2K20.33497991
136LCK0.33283874
137FGFR40.32309605
138MAPKAPK20.31861200
139IRAK40.28958436
140MAPK40.28940508
141EIF2AK20.28938430
142TAOK10.26951023
143ATM0.26414275

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.52118562
2DNA replication_Homo sapiens_hsa030304.63800389
3Proteasome_Homo sapiens_hsa030503.93164565
4Mismatch repair_Homo sapiens_hsa034303.76832123
5RNA polymerase_Homo sapiens_hsa030203.11891019
6Base excision repair_Homo sapiens_hsa034103.07674784
7Spliceosome_Homo sapiens_hsa030403.05017323
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.93612830
9Pyrimidine metabolism_Homo sapiens_hsa002402.60888420
10Homologous recombination_Homo sapiens_hsa034402.60090021
11RNA transport_Homo sapiens_hsa030132.39495118
12Nucleotide excision repair_Homo sapiens_hsa034202.39217585
13Parkinsons disease_Homo sapiens_hsa050122.20802586
14Oxidative phosphorylation_Homo sapiens_hsa001902.18529167
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.16711606
16One carbon pool by folate_Homo sapiens_hsa006702.09388056
17Sulfur relay system_Homo sapiens_hsa041221.88371225
18Allograft rejection_Homo sapiens_hsa053301.87806451
19Asthma_Homo sapiens_hsa053101.84842903
20Cell cycle_Homo sapiens_hsa041101.74659033
21Autoimmune thyroid disease_Homo sapiens_hsa053201.73881037
22Leishmaniasis_Homo sapiens_hsa051401.70093810
23Huntingtons disease_Homo sapiens_hsa050161.67613322
24Graft-versus-host disease_Homo sapiens_hsa053321.54201803
25RNA degradation_Homo sapiens_hsa030181.50088890
26Folate biosynthesis_Homo sapiens_hsa007901.47155401
27Non-homologous end-joining_Homo sapiens_hsa034501.45794021
28Lysosome_Homo sapiens_hsa041421.43656450
29Protein export_Homo sapiens_hsa030601.40260079
30Fanconi anemia pathway_Homo sapiens_hsa034601.38322748
31Staphylococcus aureus infection_Homo sapiens_hsa051501.34929114
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31614205
33Viral myocarditis_Homo sapiens_hsa054161.28293550
34Alzheimers disease_Homo sapiens_hsa050101.25915697
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23560357
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22818262
37Purine metabolism_Homo sapiens_hsa002301.22564449
38Basal transcription factors_Homo sapiens_hsa030221.19666803
39Osteoclast differentiation_Homo sapiens_hsa043801.18037410
40Pentose phosphate pathway_Homo sapiens_hsa000301.17502033
41Type I diabetes mellitus_Homo sapiens_hsa049401.15621864
42mRNA surveillance pathway_Homo sapiens_hsa030151.14692499
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.14268887
44Prion diseases_Homo sapiens_hsa050201.12533813
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10389011
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08153099
47Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07981592
48p53 signaling pathway_Homo sapiens_hsa041151.06836390
49Tuberculosis_Homo sapiens_hsa051521.06733712
50Biosynthesis of amino acids_Homo sapiens_hsa012301.04625648
51Salmonella infection_Homo sapiens_hsa051321.04267337
52NF-kappa B signaling pathway_Homo sapiens_hsa040641.02869509
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02508263
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.01804546
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.96244405
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96074832
57Carbon metabolism_Homo sapiens_hsa012000.93193680
58Pertussis_Homo sapiens_hsa051330.92551030
59Epstein-Barr virus infection_Homo sapiens_hsa051690.91725356
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90214512
61Fatty acid elongation_Homo sapiens_hsa000620.90048997
62Toxoplasmosis_Homo sapiens_hsa051450.81968327
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80496830
64VEGF signaling pathway_Homo sapiens_hsa043700.78449972
65Antigen processing and presentation_Homo sapiens_hsa046120.77200368
66Primary immunodeficiency_Homo sapiens_hsa053400.75863328
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75859769
68Thyroid cancer_Homo sapiens_hsa052160.72342702
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72284278
70Rheumatoid arthritis_Homo sapiens_hsa053230.72103697
71Fructose and mannose metabolism_Homo sapiens_hsa000510.71780014
72Galactose metabolism_Homo sapiens_hsa000520.71009258
73Selenocompound metabolism_Homo sapiens_hsa004500.70546849
74Non-small cell lung cancer_Homo sapiens_hsa052230.69536338
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69305058
76Herpes simplex infection_Homo sapiens_hsa051680.69088481
77Glutathione metabolism_Homo sapiens_hsa004800.68600516
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67439396
79Arginine biosynthesis_Homo sapiens_hsa002200.67326403
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65419721
81Chronic myeloid leukemia_Homo sapiens_hsa052200.64787849
82Pancreatic cancer_Homo sapiens_hsa052120.62546581
83Phagosome_Homo sapiens_hsa041450.62286561
84Cardiac muscle contraction_Homo sapiens_hsa042600.61012556
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60512813
86Tyrosine metabolism_Homo sapiens_hsa003500.60105811
87Endocytosis_Homo sapiens_hsa041440.59696097
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58546711
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56830646
90Systemic lupus erythematosus_Homo sapiens_hsa053220.55638855
91Pyruvate metabolism_Homo sapiens_hsa006200.54064678
92N-Glycan biosynthesis_Homo sapiens_hsa005100.53899830
93Legionellosis_Homo sapiens_hsa051340.53817673
94Malaria_Homo sapiens_hsa051440.52547652
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51748161
96Metabolic pathways_Homo sapiens_hsa011000.51168273
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49432042
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49070658
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47460684
100Oocyte meiosis_Homo sapiens_hsa041140.47459154
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.46743857
102Hepatitis C_Homo sapiens_hsa051600.46439200
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.46243053
104Shigellosis_Homo sapiens_hsa051310.46133362
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45686202
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45075686
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44852347
108Acute myeloid leukemia_Homo sapiens_hsa052210.43149275
109Vibrio cholerae infection_Homo sapiens_hsa051100.40510453
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40272793
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39541730
112Viral carcinogenesis_Homo sapiens_hsa052030.38064726
113Arginine and proline metabolism_Homo sapiens_hsa003300.37202455
114HTLV-I infection_Homo sapiens_hsa051660.35704342
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33655560
116Apoptosis_Homo sapiens_hsa042100.33143698
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30611747
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30482429
119Bladder cancer_Homo sapiens_hsa052190.29844588
120Other glycan degradation_Homo sapiens_hsa005110.29453151
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23852909
122HIF-1 signaling pathway_Homo sapiens_hsa040660.18348892
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17499871
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16387607
125Vitamin B6 metabolism_Homo sapiens_hsa007500.14080010
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.12235460
127Measles_Homo sapiens_hsa051620.11961587
128Intestinal immune network for IgA production_Homo sapiens_hsa046720.11519490
129Renin-angiotensin system_Homo sapiens_hsa046140.10311935
130Hepatitis B_Homo sapiens_hsa051610.10113090
131Arachidonic acid metabolism_Homo sapiens_hsa005900.08331548
132B cell receptor signaling pathway_Homo sapiens_hsa046620.07550905
133Alcoholism_Homo sapiens_hsa050340.06326142
134Propanoate metabolism_Homo sapiens_hsa006400.06288720
135Peroxisome_Homo sapiens_hsa041460.05542251
136Hematopoietic cell lineage_Homo sapiens_hsa046400.05521179
137Phenylalanine metabolism_Homo sapiens_hsa003600.04546834
138Notch signaling pathway_Homo sapiens_hsa043300.00939834
139Influenza A_Homo sapiens_hsa051640.00407008
140Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.00184960
141Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0224583

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