ARL6IP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)4.89861386
2cytidine deamination (GO:0009972)4.00769451
3cytidine metabolic process (GO:0046087)4.00769451
4cytidine catabolic process (GO:0006216)4.00769451
5muscle filament sliding (GO:0030049)3.95814448
6actin-myosin filament sliding (GO:0033275)3.95814448
7regulation of regulatory T cell differentiation (GO:0045589)3.62233462
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.60319341
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.60319341
10pyrimidine ribonucleoside catabolic process (GO:0046133)3.60023169
11synaptic vesicle maturation (GO:0016188)3.55950236
12neutrophil activation involved in immune response (GO:0002283)3.55943729
13regulation of B cell receptor signaling pathway (GO:0050855)3.51041507
14cellular response to interleukin-15 (GO:0071350)3.45882754
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.44973705
16synaptic vesicle docking involved in exocytosis (GO:0016081)3.42409048
17COPI coating of Golgi vesicle (GO:0048205)3.31730496
18Golgi transport vesicle coating (GO:0048200)3.31730496
19regulation of synapse structural plasticity (GO:0051823)3.28026104
20regulation of T cell mediated cytotoxicity (GO:0001914)3.22946366
21positive regulation of T cell mediated cytotoxicity (GO:0001916)3.22111024
22activation of protein kinase A activity (GO:0034199)3.22029295
23immunoglobulin mediated immune response (GO:0016064)3.20731339
24antigen processing and presentation of endogenous antigen (GO:0019883)3.18514428
25positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.18229109
26activated T cell proliferation (GO:0050798)3.13394591
27regulation of memory T cell differentiation (GO:0043380)3.12569231
28DNA deamination (GO:0045006)3.11701918
29sodium ion export (GO:0071436)3.10119205
30sarcomere organization (GO:0045214)3.06883619
31regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.06178444
32sarcoplasmic reticulum calcium ion transport (GO:0070296)3.03770991
33actin-mediated cell contraction (GO:0070252)3.03356838
34negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.02575746
35positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.94864383
36positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.93176755
37skeletal muscle contraction (GO:0003009)2.93170610
38oxaloacetate metabolic process (GO:0006107)2.92691496
39skeletal muscle fiber development (GO:0048741)2.92407195
40stress fiber assembly (GO:0043149)2.92258301
41regulation of leukocyte mediated cytotoxicity (GO:0001910)2.90341832
42regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.88126906
43regulation of natural killer cell mediated immunity (GO:0002715)2.88126906
44regulation of skeletal muscle contraction (GO:0014819)2.85342407
45neutrophil activation (GO:0042119)2.85150649
46negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.84674650
47negative regulation of cell killing (GO:0031342)2.84674650
48positive regulation of natural killer cell mediated immunity (GO:0002717)2.84541201
49synaptic vesicle exocytosis (GO:0016079)2.80285401
50barbed-end actin filament capping (GO:0051016)2.77147529
51regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.77103027
52actin nucleation (GO:0045010)2.76486035
53glutamate secretion (GO:0014047)2.76427359
54positive regulation of myotube differentiation (GO:0010831)2.73710347
55B cell mediated immunity (GO:0019724)2.73665738
56cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.70921593
57regulation of activation of Janus kinase activity (GO:0010533)2.70743170
58protein targeting to plasma membrane (GO:0072661)2.70456508
59granulocyte activation (GO:0036230)2.70016517
60positive regulation of gamma-delta T cell activation (GO:0046645)2.69760002
61regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.68847299
62pyrimidine nucleoside catabolic process (GO:0046135)2.68795152
63negative regulation of potassium ion transmembrane transport (GO:1901380)2.67895856
64locomotory exploration behavior (GO:0035641)2.67609642
65protein localization to endosome (GO:0036010)2.66713304
66regulation of synaptic vesicle exocytosis (GO:2000300)2.66081521
67negative regulation of cell size (GO:0045792)2.65550240
68regulation of alpha-beta T cell proliferation (GO:0046640)2.65523768
69negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.65428270
70regulation of cell killing (GO:0031341)2.64856638
71positive regulation of alpha-beta T cell proliferation (GO:0046641)2.63999522
72regulation of T cell receptor signaling pathway (GO:0050856)2.63865698
73positive regulation of cell killing (GO:0031343)2.63335268
74regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.63315831
75actin filament-based movement (GO:0030048)2.61381240
76negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.60985105
77negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.60764320
78positive regulation of B cell differentiation (GO:0045579)2.60581936
79tricarboxylic acid cycle (GO:0006099)2.59262192
80cellular potassium ion homeostasis (GO:0030007)2.59127309
81mast cell activation (GO:0045576)2.58594946
82lymphocyte chemotaxis (GO:0048247)2.58144168
83leukocyte degranulation (GO:0043299)2.57798951
84NADH metabolic process (GO:0006734)2.57660124
85positive T cell selection (GO:0043368)2.57368891
86positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.57175301
87regulation of T cell tolerance induction (GO:0002664)2.56892148
88regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.55393204
89negative regulation of fatty acid transport (GO:2000192)2.54735040
90regulation of isotype switching to IgG isotypes (GO:0048302)2.54533093
91regulation of defense response to virus by virus (GO:0050690)2.53717678
92negative regulation of T cell apoptotic process (GO:0070233)2.53706281
93regulation of germinal center formation (GO:0002634)2.53093406
94interferon-gamma-mediated signaling pathway (GO:0060333)2.51594000
95positive regulation of antigen processing and presentation (GO:0002579)2.51331496
96regulation of cell communication by electrical coupling (GO:0010649)2.50084381
97regulation of antigen processing and presentation (GO:0002577)2.48834682
98T cell migration (GO:0072678)2.48479302
99regulation of short-term neuronal synaptic plasticity (GO:0048172)2.47187593
100thrombin receptor signaling pathway (GO:0070493)2.47090498
101antigen processing and presentation via MHC class Ib (GO:0002475)2.46631817
102regulation of dendritic cell antigen processing and presentation (GO:0002604)2.46413033
103negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.46169066
104cell communication by electrical coupling (GO:0010644)2.46132786
105positive regulation of defense response to virus by host (GO:0002230)2.45054891
106striated muscle contraction (GO:0006941)2.44772405
107T cell costimulation (GO:0031295)2.42750955
108cytoskeletal anchoring at plasma membrane (GO:0007016)2.41431210
109signal complex assembly (GO:0007172)2.41423230
110positive regulation of interleukin-8 secretion (GO:2000484)2.41196147
111positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.40788472
112response to interferon-beta (GO:0035456)2.40494108
113protein neddylation (GO:0045116)2.40111569
114negative regulation of lymphocyte mediated immunity (GO:0002707)2.39541250
115lymphocyte costimulation (GO:0031294)2.39129143
116positive regulation of axon extension (GO:0045773)2.38816535
117regulation of gamma-delta T cell activation (GO:0046643)2.38558022
118negative regulation of T cell receptor signaling pathway (GO:0050860)2.38532635
119antigen receptor-mediated signaling pathway (GO:0050851)2.38415817
120negative T cell selection (GO:0043383)2.37635051
121regulation of calcium ion transmembrane transporter activity (GO:1901019)2.36438679
122regulation of calcium ion transmembrane transport (GO:1903169)2.36438679
123positive regulation of tolerance induction (GO:0002645)2.36333339
124myotube cell development (GO:0014904)2.36083826
125regulation of tolerance induction (GO:0002643)2.35680049
126regulation of synaptic vesicle transport (GO:1902803)2.34988630
127positive regulation of fibroblast migration (GO:0010763)2.34932216
128antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.34566135
129negative regulation of T cell mediated immunity (GO:0002710)2.34249837
130negative thymic T cell selection (GO:0045060)2.34184368
131regulation of gamma-delta T cell differentiation (GO:0045586)2.34023733
132regulation of T cell chemotaxis (GO:0010819)2.33930552
133positive regulation of T cell chemotaxis (GO:0010820)2.33930552
134positive regulation of macrophage differentiation (GO:0045651)2.33441230
135regulation of lymphocyte chemotaxis (GO:1901623)2.32777237
136platelet dense granule organization (GO:0060155)2.32554345
137cardiac muscle contraction (GO:0060048)2.32274551
138regulation of relaxation of muscle (GO:1901077)2.31619594
139regulation of interleukin-8 secretion (GO:2000482)2.31518492
140positive regulation of lymphocyte migration (GO:2000403)2.31332446
141regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.31108556
142positive regulation of myoblast differentiation (GO:0045663)2.30695902
143negative regulation of nitric oxide biosynthetic process (GO:0045019)2.30209193
144regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.29924900
145negative regulation of leukocyte mediated immunity (GO:0002704)2.29842161
146negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.29778055
147regulation of calcium-mediated signaling (GO:0050848)2.29550740
148T cell receptor signaling pathway (GO:0050852)2.29463125
149positive regulation of mast cell activation (GO:0033005)2.29461993
150dendritic cell chemotaxis (GO:0002407)2.29375545
151negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.28705228
152dendritic cell migration (GO:0036336)2.28448280
153myeloid cell activation involved in immune response (GO:0002275)2.28445872
154cell adhesion mediated by integrin (GO:0033627)2.28445509
155muscle fiber development (GO:0048747)2.28368551
156apoptotic cell clearance (GO:0043277)2.28035657
157B cell receptor signaling pathway (GO:0050853)2.27092147
158heterotypic cell-cell adhesion (GO:0034113)2.26950054
159retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.26443890
160regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.26397584
161regulation of mast cell activation (GO:0033003)2.25416337
162positive regulation of calcium-mediated signaling (GO:0050850)2.25324049
163positive regulation of lamellipodium assembly (GO:0010592)2.24955716
164cellular defense response (GO:0006968)2.24163150
165potassium ion import (GO:0010107)2.24154811
166membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.22602442
167regulation of tight junction assembly (GO:2000810)2.22492724
168actomyosin structure organization (GO:0031032)2.22068761
169thymic T cell selection (GO:0045061)2.19421157
170regulation of ARF protein signal transduction (GO:0032012)2.17794869
171regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.16773327
172positive thymic T cell selection (GO:0045059)2.16622225
173proline transport (GO:0015824)2.16240451
174muscle contraction (GO:0006936)2.15892547
175cardiac myofibril assembly (GO:0055003)2.14361260
176membrane raft organization (GO:0031579)2.10796174
177succinate metabolic process (GO:0006105)2.10666315
178positive regulation of vesicle fusion (GO:0031340)2.10047004
179regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.07870285
180endocytic recycling (GO:0032456)2.07825585
181syncytium formation (GO:0006949)2.07245462
182Arp2/3 complex-mediated actin nucleation (GO:0034314)2.06475979
183vocalization behavior (GO:0071625)2.05849785
184regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.05799756
185cell communication involved in cardiac conduction (GO:0086065)2.05707937
186response to interleukin-15 (GO:0070672)2.05084354
187regulation of sodium ion transmembrane transporter activity (GO:2000649)2.04413322

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.77645875
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.08954914
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.00974917
4* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.91942147
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.84308712
6LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.69052327
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.39493045
8* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.28183717
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.26163270
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.24506534
11LXR_22292898_ChIP-Seq_THP-1_Human2.08701500
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.08670359
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.03614433
14KDM2B_26808549_Chip-Seq_DND41_Human1.98140576
15CLOCK_20551151_ChIP-Seq_293T_Human1.94930493
16TRIM28_21343339_ChIP-Seq_HEK293_Human1.91831786
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.87670126
18DNAJC2_21179169_ChIP-ChIP_NT2_Human1.85834067
19MYC_22102868_ChIP-Seq_BL_Human1.81934177
20LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.80516878
21ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79747298
22RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.73796919
23TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72400111
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.72336789
25ZFP281_18757296_ChIP-ChIP_E14_Mouse1.68324782
26RUNX_20019798_ChIP-Seq_JUKART_Human1.65464529
27SPI1_23127762_ChIP-Seq_K562_Human1.64311942
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60644292
29* GATA3_26560356_Chip-Seq_TH2_Human1.59896570
30SCL_19346495_ChIP-Seq_HPC-7_Human1.59074328
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.58020132
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.55225121
33* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55078773
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54791393
35EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.53652575
36* MAF_26560356_Chip-Seq_TH1_Human1.52737808
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.52121894
38DROSHA_22980978_ChIP-Seq_HELA_Human1.51971426
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51695770
40ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.50919716
41TCF7_22412390_ChIP-Seq_EML_Mouse1.50668683
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50384643
43* GATA3_27048872_Chip-Seq_THYMUS_Human1.49572168
44* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47947300
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47708810
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.47216486
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46477967
48* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46185073
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45631253
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.45212218
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44959404
52IRF8_22096565_ChIP-ChIP_GC-B_Human1.44645599
53SPI1_23547873_ChIP-Seq_NB4_Human1.43515451
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43339037
55SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41861298
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40510790
57KDM2B_26808549_Chip-Seq_K562_Human1.40114430
58* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.39554361
59PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38440002
60NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37824350
61* RACK7_27058665_Chip-Seq_MCF-7_Human1.37658247
62GBX2_23144817_ChIP-Seq_PC3_Human1.35929750
63VDR_21846776_ChIP-Seq_THP-1_Human1.35754541
64UTX_26944678_Chip-Seq_JUKART_Human1.35537397
65* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35140915
66TBX20_22080862_ChIP-Seq_HEART_Mouse1.34151523
67TBX20_22328084_ChIP-Seq_HEART_Mouse1.34151523
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33769933
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33732346
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31435268
71* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30429928
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29583792
73* GATA2_21666600_ChIP-Seq_HMVEC_Human1.29323901
74SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28769678
75SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27368183
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.25345884
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.22904936
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21803993
79* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21565777
80VDR_24787735_ChIP-Seq_THP-1_Human1.21319376
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20277290
82ATF3_27146783_Chip-Seq_COLON_Human1.19359842
83MTF2_20144788_ChIP-Seq_MESCs_Mouse1.16644728
84IRF8_27001747_Chip-Seq_BMDM_Mouse1.16313569
85ZNF263_19887448_ChIP-Seq_K562_Human1.16282912
86* MYB_26560356_Chip-Seq_TH1_Human1.15779017
87PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15498130
88* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12701730
89SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12308305
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.12077831
91* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.11364379
92* MYB_26560356_Chip-Seq_TH2_Human1.10340093
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09925625
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09887598
95* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09609371
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09326831
97NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09326831
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08003190
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07822753
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07679557
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.06850561
102STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.06594312
103HTT_18923047_ChIP-ChIP_STHdh_Human1.06105249
104* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06063935
105IRF8_21731497_ChIP-ChIP_J774_Mouse1.05874957
106VDR_24763502_ChIP-Seq_THP-1_Human1.04740862
107TAF15_26573619_Chip-Seq_HEK293_Human1.04557338
108TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.04365020
109STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04082234
110GATA1_19941826_ChIP-Seq_K562_Human1.03945493
111GATA1_19941827_ChIP-Seq_MEL_Mouse1.03508973
112GATA1_22025678_ChIP-Seq_K562_Human1.03489000
113BCL6_27268052_Chip-Seq_Bcells_Human1.02406926
114SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00865668
115FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00687727
116FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00314829
117SMC4_20622854_ChIP-Seq_HELA_Human1.00252665
118NFE2_27457419_Chip-Seq_LIVER_Mouse0.99840363
119SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99780038
120CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99749701
121PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99707154
122* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99668421
123* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98367603
124GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98102726
125GATA2_19941826_ChIP-Seq_K562_Human0.97889060
126SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97830203
127NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97767019
128EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97351277
129RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97351277
130DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97059688
131EP300_21415370_ChIP-Seq_HL-1_Mouse0.96787634
132STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96604822
133SALL4_22934838_ChIP-ChIP_CD34+_Human0.96562828
134HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96198253
135FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95964268
136ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94873182
137TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94257898
138CRX_20693478_ChIP-Seq_RETINA_Mouse0.94069065
139ESR1_21235772_ChIP-Seq_MCF-7_Human0.94011195
140* RUNX1_22412390_ChIP-Seq_EML_Mouse0.93692177
141EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92381635
142JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92015276
143STAT1_20625510_ChIP-Seq_HELA_Human0.91140755
144JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85809885
145* SOX2_19829295_ChIP-Seq_ESCs_Human0.85004327
146* NANOG_19829295_ChIP-Seq_ESCs_Human0.85004327
147CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84464318
148SMRT_27268052_Chip-Seq_Bcells_Human0.84114481
149BCAT_22108803_ChIP-Seq_LS180_Human0.81204311
150CJUN_26792858_Chip-Seq_BT549_Human0.81188713
151AR_20517297_ChIP-Seq_VCAP_Human0.80773180
152TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80674175
153P53_22387025_ChIP-Seq_ESCs_Mouse0.80146395
154OCT4_21477851_ChIP-Seq_ESCs_Mouse0.79620918
155* SOX2_20726797_ChIP-Seq_SW620_Human0.78758703
156* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78368582
157SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.77808308
158BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77760758
159CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.77218005
160TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77063876
161CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.76891679
162CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76619050
163PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.76293885
164CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.75537590
165PRDM14_20953172_ChIP-Seq_ESCs_Human0.75386328
166VDR_22108803_ChIP-Seq_LS180_Human0.75208233
167CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74632821
168GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.74525260
169FOXA1_25329375_ChIP-Seq_VCAP_Human0.73499048
170FOXA1_27270436_Chip-Seq_PROSTATE_Human0.73499048
171SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.73314033

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.86015258
2MP0000751_myopathy3.56322085
3MP0000749_muscle_degeneration3.06221575
4MP0004859_abnormal_synaptic_plasticity3.06103800
5MP0009785_altered_susceptibility_to2.77351622
6MP0002837_dystrophic_cardiac_calcinosis2.70866233
7MP0002148_abnormal_hypersensitivity_rea2.65819643
8MP0008438_abnormal_cutaneous_collagen2.57948191
9MP0003705_abnormal_hypodermis_morpholog2.27778041
10MP0001800_abnormal_humoral_immune2.26010300
11MP0000747_muscle_weakness2.25765996
12MP0004084_abnormal_cardiac_muscle2.23912554
13MP0000750_abnormal_muscle_regeneration2.21084351
14MP0002723_abnormal_immune_serum2.16444255
15MP0005025_abnormal_response_to2.13593177
16MP0004130_abnormal_muscle_cell2.11325720
17MP0000013_abnormal_adipose_tissue2.09649383
18MP0004510_myositis2.08824939
19MP0004270_analgesia2.07626525
20MP0003303_peritoneal_inflammation2.07084988
21MP0002452_abnormal_antigen_presenting2.04252386
22MP0000465_gastrointestinal_hemorrhage2.00673198
23MP0003300_gastrointestinal_ulcer1.98077089
24MP0003279_aneurysm1.97253584
25MP0004087_abnormal_muscle_fiber1.95896553
26MP0001819_abnormal_immune_cell1.94091303
27MP0009780_abnormal_chondrocyte_physiolo1.93618979
28MP0004036_abnormal_muscle_relaxation1.91151776
29MP0004858_abnormal_nervous_system1.88621839
30MP0004145_abnormal_muscle_electrophysio1.87358745
31MP0000759_abnormal_skeletal_muscle1.80190505
32MP0005058_abnormal_lysosome_morphology1.74767303
33MP0010155_abnormal_intestine_physiology1.72566713
34MP0000733_abnormal_muscle_development1.72212304
35MP0002106_abnormal_muscle_physiology1.67580874
36MP0003329_amyloid_beta_deposits1.67323078
37MP0001958_emphysema1.63630629
38MP0002405_respiratory_system_inflammati1.63547629
39MP0001845_abnormal_inflammatory_respons1.62440867
40MP0009333_abnormal_splenocyte_physiolog1.61174268
41MP0003566_abnormal_cell_adhesion1.59631277
42MP0002269_muscular_atrophy1.57660041
43MP0002166_altered_tumor_susceptibility1.56012357
44MP0003866_abnormal_defecation1.54839080
45MP0003191_abnormal_cellular_cholesterol1.52114690
46MP0002909_abnormal_adrenal_gland1.50968838
47MP0001968_abnormal_touch/_nociception1.48956962
48MP0002736_abnormal_nociception_after1.47769132
49MP0003635_abnormal_synaptic_transmissio1.47371139
50MP0000604_amyloidosis1.47019572
51MP0005275_abnormal_skin_tensile1.43831048
52MP0003172_abnormal_lysosome_physiology1.42000951
53MP0003646_muscle_fatigue1.40205859
54MP0005369_muscle_phenotype1.39743083
55MP0005330_cardiomyopathy1.38868658
56MP0005623_abnormal_meninges_morphology1.38350567
57MP0003075_altered_response_to1.37804384
58MP0005620_abnormal_muscle_contractility1.36960072
59MP0000716_abnormal_immune_system1.36759318
60MP0004215_abnormal_myocardial_fiber1.34551052
61MP0008961_abnormal_basal_metabolism1.33274142
62MP0002398_abnormal_bone_marrow1.32424844
63MP0004233_abnormal_muscle_weight1.31911832
64MP0002972_abnormal_cardiac_muscle1.31879040
65MP0003045_fibrosis1.30977888
66MP0003091_abnormal_cell_migration1.25858213
67MP0003806_abnormal_nucleotide_metabolis1.20424604
68MP0002735_abnormal_chemical_nociception1.20147285
69MP0003436_decreased_susceptibility_to1.19755068
70MP0002877_abnormal_melanocyte_morpholog1.19541298
71MP0000689_abnormal_spleen_morphology1.19379390
72MP0004484_altered_response_of1.18228766
73MP0009764_decreased_sensitivity_to1.18135509
74MP0008469_abnormal_protein_level1.17585383
75MP0008569_lethality_at_weaning1.17177557
76MP0010386_abnormal_urinary_bladder1.16413754
77MP0003828_pulmonary_edema1.14029305
78MP0000343_altered_response_to1.13504191
79MP0001533_abnormal_skeleton_physiology1.10278074
80MP0003879_abnormal_hair_cell1.09870332
81MP0005075_abnormal_melanosome_morpholog1.08062321
82MP0005310_abnormal_salivary_gland1.07862740
83MP0000685_abnormal_immune_system1.06883857
84MP0003183_abnormal_peptide_metabolism1.06176095
85MP0009763_increased_sensitivity_to1.05550115
86MP0006054_spinal_hemorrhage1.05317861
87MP0002722_abnormal_immune_system1.02611503
88MP0003195_calcinosis1.01915698
89MP0002429_abnormal_blood_cell1.01439683
90MP0002734_abnormal_mechanical_nocicepti1.00924780
91MP0002064_seizures1.00200100
92MP0002933_joint_inflammation0.98897431
93MP0002006_tumorigenesis0.98728072
94MP0001348_abnormal_lacrimal_gland0.97380911
95MP0002876_abnormal_thyroid_physiology0.95650913
96MP0001542_abnormal_bone_strength0.95553704
97MP0005166_decreased_susceptibility_to0.95288657
98MP0005464_abnormal_platelet_physiology0.93813996
99MP0008775_abnormal_heart_ventricle0.93214032
100MP0005023_abnormal_wound_healing0.93143616
101MP0002138_abnormal_hepatobiliary_system0.92926670
102MP0000858_altered_metastatic_potential0.92707674
103MP0002063_abnormal_learning/memory/cond0.92647157
104MP0001544_abnormal_cardiovascular_syste0.91992217
105MP0005385_cardiovascular_system_phenoty0.91992217
106MP0002108_abnormal_muscle_morphology0.91703401
107MP0001853_heart_inflammation0.91660238
108MP0005084_abnormal_gallbladder_morpholo0.91608143
109MP0001986_abnormal_taste_sensitivity0.91156995
110MP0004947_skin_inflammation0.90976249
111MP0003448_altered_tumor_morphology0.90719591
112MP0009745_abnormal_behavioral_response0.90664148
113MP0000230_abnormal_systemic_arterial0.90152252
114MP0005000_abnormal_immune_tolerance0.89941135
115MP0005535_abnormal_body_temperature0.89194481
116MP0003011_delayed_dark_adaptation0.88365573
117MP0001835_abnormal_antigen_presentation0.87929690
118MP0010630_abnormal_cardiac_muscle0.87921717
119MP0001851_eye_inflammation0.87643534
120MP0002998_abnormal_bone_remodeling0.87385657
121MP0004811_abnormal_neuron_physiology0.87339152
122MP0001501_abnormal_sleep_pattern0.87249045
123MP0006036_abnormal_mitochondrial_physio0.86924232
124MP0005671_abnormal_response_to0.86822519
125MP0005503_abnormal_tendon_morphology0.86782138
126MP0000003_abnormal_adipose_tissue0.86685924
127MP0001299_abnormal_eye_distance/0.86161220
128MP0006082_CNS_inflammation0.86030193
129MP0001790_abnormal_immune_system0.85694455
130MP0005387_immune_system_phenotype0.85694455
131MP0000920_abnormal_myelination0.85573001
132MP0008874_decreased_physiological_sensi0.83089488
133MP0000249_abnormal_blood_vessel0.83008281
134MP0005167_abnormal_blood-brain_barrier0.82024600
135MP0003633_abnormal_nervous_system0.81844951
136MP0001970_abnormal_pain_threshold0.81127075
137MP0002089_abnormal_postnatal_growth/wei0.80963729
138MP0002733_abnormal_thermal_nociception0.80606715
139MP0005165_increased_susceptibility_to0.80605544
140MP0005164_abnormal_response_to0.79856151
141MP0005390_skeleton_phenotype0.78339723
142MP0010352_gastrointestinal_tract_polyps0.78325206
143MP0000703_abnormal_thymus_morphology0.77627207
144MP0003656_abnormal_erythrocyte_physiolo0.77589502
145MP0000372_irregular_coat_pigmentation0.76708306
146MP0003690_abnormal_glial_cell0.74902386
147MP0002419_abnormal_innate_immunity0.74531674
148MP0004883_abnormal_blood_vessel0.74371470
149MP0000569_abnormal_digit_pigmentation0.73923319
150MP0001765_abnormal_ion_homeostasis0.73019860
151MP0001905_abnormal_dopamine_level0.72974911
152MP0003221_abnormal_cardiomyocyte_apopto0.72213865
153MP0002896_abnormal_bone_mineralization0.72188327
154MP0003763_abnormal_thymus_physiology0.72093884
155MP0008004_abnormal_stomach_pH0.71726056
156MP0002420_abnormal_adaptive_immunity0.71380298
157MP0001873_stomach_inflammation0.71191753
158MP0000015_abnormal_ear_pigmentation0.70686579
159MP0005397_hematopoietic_system_phenotyp0.69607362
160MP0001545_abnormal_hematopoietic_system0.69607362

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.60414408
2Type 1 muscle fiber predominance (HP:0003803)4.55912607
3Muscle fiber inclusion bodies (HP:0100299)4.53319771
4Nemaline bodies (HP:0003798)4.18905368
5Distal arthrogryposis (HP:0005684)4.08767459
6Petechiae (HP:0000967)3.92802251
7Prolonged bleeding time (HP:0003010)3.85087248
8Stomatitis (HP:0010280)3.82345018
9Abnormality of T cell number (HP:0011839)3.74804691
10T lymphocytopenia (HP:0005403)3.73040208
11Elevated erythrocyte sedimentation rate (HP:0003565)3.58797900
12Exercise-induced myalgia (HP:0003738)3.58195578
13Ulnar deviation of the wrist (HP:0003049)3.54668477
14Round ear (HP:0100830)3.51670418
15Fetal akinesia sequence (HP:0001989)3.48513532
16Exercise-induced muscle cramps (HP:0003710)3.48152515
17Purpura (HP:0000979)3.47746521
18Myositis (HP:0100614)3.34754651
19Difficulty running (HP:0009046)3.32935137
20Hyporeflexia of lower limbs (HP:0002600)3.32351964
21Abnormality of skeletal muscle fiber size (HP:0012084)3.28280169
22Difficulty climbing stairs (HP:0003551)3.24277748
23Abnormality of liposaccharide metabolism (HP:0010968)3.20876754
24Abnormality of glycosphingolipid metabolism (HP:0004343)3.20876754
25Abnormality of glycolipid metabolism (HP:0010969)3.20876754
26EMG: myopathic abnormalities (HP:0003458)3.16608195
27Abnormality of macrophages (HP:0004311)3.15707386
28Increased connective tissue (HP:0009025)3.14108198
29Epistaxis (HP:0000421)3.13081680
30Increased variability in muscle fiber diameter (HP:0003557)3.12176411
31Protrusio acetabuli (HP:0003179)3.09065216
32Myopathic facies (HP:0002058)3.02695865
33Optic neuritis (HP:0100653)3.02299123
34Retrobulbar optic neuritis (HP:0100654)3.02299123
35Muscle fiber splitting (HP:0003555)2.99670977
36Increased IgM level (HP:0003496)2.98933250
37Myotonia (HP:0002486)2.97610538
38Frequent falls (HP:0002359)2.96153142
39Orchitis (HP:0100796)2.95472849
40Gingival bleeding (HP:0000225)2.94098140
41Malignant hyperthermia (HP:0002047)2.90232860
42Autoimmune hemolytic anemia (HP:0001890)2.87909899
43IgG deficiency (HP:0004315)2.85335556
44Abnormality of T cells (HP:0002843)2.81856783
45Eczematoid dermatitis (HP:0000976)2.81154600
46Abnormality of the calf musculature (HP:0001430)2.80697864
47Recurrent abscess formation (HP:0002722)2.78436385
48Pulmonary infiltrates (HP:0002113)2.75034989
49Asymmetric septal hypertrophy (HP:0001670)2.72991021
50Abnormality of the prostate (HP:0008775)2.69677204
51Cerebral aneurysm (HP:0004944)2.66816890
52Hepatosplenomegaly (HP:0001433)2.66330098
53Recurrent bacterial skin infections (HP:0005406)2.65810640
54Joint swelling (HP:0001386)2.65747625
55Calf muscle hypertrophy (HP:0008981)2.65685869
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.62280115
57Encephalitis (HP:0002383)2.61231335
58Fatigable weakness (HP:0003473)2.57363058
59Abnormality of the neuromuscular junction (HP:0003398)2.57363058
60Vasculitis (HP:0002633)2.55838266
61Increased density of long bones (HP:0006392)2.54120925
62Recurrent fungal infections (HP:0002841)2.53571460
63Akinesia (HP:0002304)2.49841255
64Recurrent cutaneous fungal infections (HP:0011370)2.48331298
65Chronic mucocutaneous candidiasis (HP:0002728)2.48331298
66Mildly elevated creatine phosphokinase (HP:0008180)2.48086553
67Distal lower limb amyotrophy (HP:0008944)2.47573180
68Premature rupture of membranes (HP:0001788)2.46464957
69Abnormality of eosinophils (HP:0001879)2.46253069
70Vacuolated lymphocytes (HP:0001922)2.45602300
71Spontaneous hematomas (HP:0007420)2.44879446
72Chronic obstructive pulmonary disease (HP:0006510)2.44486141
73Obstructive lung disease (HP:0006536)2.44486141
74Hemoptysis (HP:0002105)2.44168076
75Muscle hypertrophy of the lower extremities (HP:0008968)2.43642926
76Abnormal platelet volume (HP:0011876)2.42360606
77Eosinophilia (HP:0001880)2.41842004
78Limb-girdle muscle atrophy (HP:0003797)2.41662381
79Menorrhagia (HP:0000132)2.39013713
80Chronic diarrhea (HP:0002028)2.38489365
81Leukocytosis (HP:0001974)2.38253840
82Pustule (HP:0200039)2.38050135
83Gastrointestinal infarctions (HP:0005244)2.37766939
84Centrally nucleated skeletal muscle fibers (HP:0003687)2.35712413
85Scapular winging (HP:0003691)2.35558862
86Meningitis (HP:0001287)2.35491570
87Aortic aneurysm (HP:0004942)2.34762990
88Upper limb amyotrophy (HP:0009129)2.34445380
89Distal upper limb amyotrophy (HP:0007149)2.34445380
90Popliteal pterygium (HP:0009756)2.34034531
91Sudden death (HP:0001699)2.33808223
92Gowers sign (HP:0003391)2.33179225
93Striae distensae (HP:0001065)2.32712564
94Lower limb amyotrophy (HP:0007210)2.32318698
95Chest pain (HP:0100749)2.32144717
96Increased cerebral lipofuscin (HP:0011813)2.31187376
97Increased mean platelet volume (HP:0011877)2.25752315
98Myoglobinuria (HP:0002913)2.25457681
99Recurrent skin infections (HP:0001581)2.24618645
100Calcaneovalgus deformity (HP:0001848)2.22020766
101Facial diplegia (HP:0001349)2.21381162
102Mediastinal lymphadenopathy (HP:0100721)2.20898684
103Hypergammaglobulinemia (HP:0010702)2.18730481
104Dilatation of the ascending aorta (HP:0005111)2.18425216
105Spinal rigidity (HP:0003306)2.17779773
106Pulmonary embolism (HP:0002204)2.16206090
107Pulmonary fibrosis (HP:0002206)2.15515851
108Slender build (HP:0001533)2.14858439
109Abnormality of T cell physiology (HP:0011840)2.10469813
110Granulocytopenia (HP:0001913)2.09685666
111Absent phalangeal crease (HP:0006109)2.08988711
112Achilles tendon contracture (HP:0001771)2.08672569
113Aortic dissection (HP:0002647)2.08572840
114Muscle stiffness (HP:0003552)2.08215175
115Hypercortisolism (HP:0001578)2.07083154
116Bulbar palsy (HP:0001283)2.06618446
117Keratoconjunctivitis sicca (HP:0001097)2.06305420
1183-Methylglutaconic aciduria (HP:0003535)2.05763430
119Easy fatigability (HP:0003388)2.05467468
120Neck muscle weakness (HP:0000467)2.05086657
121Keratoconjunctivitis (HP:0001096)2.04966333
122Hypoproteinemia (HP:0003075)2.04093367
123Deformed tarsal bones (HP:0008119)2.04063719
124Hyperlipoproteinemia (HP:0010980)2.03119051
125Thyroiditis (HP:0100646)2.02076954
126Urticaria (HP:0001025)2.01930245
127Gangrene (HP:0100758)1.99755718
128Metaphyseal dysplasia (HP:0100255)1.97426463
129Abnormality of binocular vision (HP:0011514)1.97243105
130Diplopia (HP:0000651)1.97243105
131Recurrent bronchitis (HP:0002837)1.97141294
132Type 2 muscle fiber atrophy (HP:0003554)1.96412836
133Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.96243096
134Decreased activity of mitochondrial respiratory chain (HP:0008972)1.96243096
135Polyneuropathy (HP:0001271)1.96215294
136Arterial thrombosis (HP:0004420)1.96097359
137Muscle fiber atrophy (HP:0100295)1.95997513
138Severe combined immunodeficiency (HP:0004430)1.94797758
139Hematochezia (HP:0002573)1.93598862
140Weak cry (HP:0001612)1.92728849
141Vertebral compression fractures (HP:0002953)1.91018814
142Broad metatarsal (HP:0001783)1.90304318
143Pheochromocytoma (HP:0002666)1.89859191
144Vertigo (HP:0002321)1.89766198
145Rapidly progressive (HP:0003678)1.89057280
146Myokymia (HP:0002411)1.87974076
147Abnormality of the Achilles tendon (HP:0005109)1.86934074
148Palpitations (HP:0001962)1.86550621
149Bundle branch block (HP:0011710)1.85612091
150Renal cortical cysts (HP:0000803)1.85048049
151Acute hepatic failure (HP:0006554)1.84842164
152Autoimmune thrombocytopenia (HP:0001973)1.83738068
153Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83605519
154Abnormality of polysaccharide metabolism (HP:0011012)1.83605519
155Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83605519
156Agammaglobulinemia (HP:0004432)1.83306149
157Dysmetric saccades (HP:0000641)1.82770389
158Thin ribs (HP:0000883)1.82319222
159Visual hallucinations (HP:0002367)1.81975918
160Generalized muscle weakness (HP:0003324)1.81260088
161Abnormality of the calcaneus (HP:0008364)1.80332801
162Increased intramyocellular lipid droplets (HP:0012240)1.80052445
163Abnormal platelet function (HP:0011869)1.79191406
164Impaired platelet aggregation (HP:0003540)1.79191406
165Rhabdomyolysis (HP:0003201)1.78774620
166Abnormality of placental membranes (HP:0011409)1.78237819
167Amniotic constriction ring (HP:0009775)1.78237819
168Distal lower limb muscle weakness (HP:0009053)1.77531226
169Amyotrophic lateral sclerosis (HP:0007354)1.75977438
170Glomerulopathy (HP:0100820)1.75913620
171Right ventricular cardiomyopathy (HP:0011663)1.75641305
172Premature loss of primary teeth (HP:0006323)1.75092663
173Anorexia (HP:0002039)1.74896727
174Urinary glycosaminoglycan excretion (HP:0003541)1.74419330
175Mucopolysacchariduria (HP:0008155)1.74419330
176Papilledema (HP:0001085)1.73694834
177EMG: neuropathic changes (HP:0003445)1.72956827
178Spinal canal stenosis (HP:0003416)1.72397276
179Progressive neurologic deterioration (HP:0002344)1.71501753
180Neuroendocrine neoplasm (HP:0100634)1.71294315
181Systemic lupus erythematosus (HP:0002725)1.71077081
182Episodic fever (HP:0001954)1.70626273
183Cervical subluxation (HP:0003308)1.67683495
184Long toe (HP:0010511)1.67591140
185Dysostosis multiplex (HP:0000943)1.67521109
186Vascular tortuosity (HP:0004948)1.66920968
187Joint stiffness (HP:0001387)1.66042046
188Abnormality of the nasal mucosa (HP:0000433)1.64462963
189Increased neuronal autofluorescent lipopigment (HP:0002074)1.64015150
190Resting tremor (HP:0002322)1.62681472
191Arterial tortuosity (HP:0005116)1.61018841
192Atonic seizures (HP:0010819)1.60873401
193Ankle contracture (HP:0006466)1.59504143
194Respiratory insufficiency due to muscle weakness (HP:0002747)1.59334956
195Subaortic stenosis (HP:0001682)1.59242238
196Abnormality of the left ventricular outflow tract (HP:0011103)1.59242238
197Shallow orbits (HP:0000586)1.59069525

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.58297718
2PKN23.42348707
3TTN3.37696703
4RIPK42.57519893
5TAOK32.36023575
6TESK22.14014047
7MST42.10543843
8KSR21.95062646
9MAP3K91.88366272
10BMPR21.86409657
11EEF2K1.79907226
12ERN11.78889950
13MAP3K141.78038022
14ADRBK21.75732425
15TEC1.74141171
16GRK61.73656478
17CAMKK11.69716979
18RIPK11.64023445
19DAPK21.59413803
20MOS1.55847864
21MAP4K11.53182100
22NEK11.52487746
23IKBKE1.51399539
24CSK1.51060421
25LRRK21.50583371
26CSF1R1.49006399
27IKBKB1.47871186
28TAOK11.46856842
29MAP4K21.46378420
30PRKCH1.46374792
31BCKDK1.46102126
32GRK71.44471917
33MAP3K121.42104156
34BTK1.40748166
35PAK61.38170581
36CAMKK21.38018708
37PHKG11.37874837
38PHKG21.37874837
39RET1.36632432
40PIK3CG1.35157927
41FGFR41.33593331
42JAK11.31316598
43OBSCN1.28424952
44LMTK21.26240349
45MAPKAPK31.25112644
46FRK1.24180637
47MAP2K31.20966141
48GRK51.19789380
49TNK21.18333849
50NTRK31.18330702
51SIK31.17779591
52BLK1.17715465
53TBK11.17128122
54LYN1.16724901
55LIMK11.12563533
56MINK11.12452347
57LCK1.11894355
58ILK1.10280920
59MUSK1.09480729
60ERBB31.08040775
61PTK61.06259959
62SCYL21.03690980
63MAP2K11.03601346
64PDGFRA1.02222513
65PRKCQ1.01330951
66ZAP701.00841290
67NTRK11.00756871
68MAP3K20.97363370
69JAK30.97300109
70MAP3K70.95981144
71DMPK0.95515354
72TESK10.94628877
73EPHB10.93694128
74TYK20.93415922
75ITK0.93124923
76DAPK30.92006096
77MAP3K130.91978157
78PRKD30.91100065
79TGFBR20.90091358
80PIM20.88057537
81MAPK120.86822125
82PINK10.86264191
83ARAF0.85397777
84PDK30.84409737
85PDK40.84409737
86BCR0.83536641
87MYLK0.83419649
88TXK0.83146338
89PTK2B0.81992645
90DAPK10.81986634
91ALK0.81852624
92MAP3K10.81826313
93DDR20.81822930
94PDK10.79957853
95FES0.79658222
96KIT0.79277657
97GRK10.78700049
98BMPR1B0.77469252
99MAP3K30.76635540
100SIK10.74912027
101FGFR30.74360719
102MAP2K40.69965709
103MAPK70.69962766
104PDPK10.68237824
105CDK190.67979184
106JAK20.67178050
107PLK20.67168112
108PAK40.67125943
109ADRBK10.66928094
110PRKCE0.66381724
111PTK20.65916819
112HCK0.65641598
113CDK50.65090058
114IGF1R0.65089747
115CDK140.64978803
116BMX0.63817423
117EIF2AK30.63809233
118PAK30.63447414
119CDK150.62677481
120MAP3K40.62647763
121FYN0.62604812
122SIK20.62598153
123CDK180.59763224
124FLT30.58420131
125LATS20.58149500
126FGR0.58133918
127MATK0.57769833
128TRPM70.56197790
129ACVR1B0.55481486
130RAF10.54888472
131NEK90.54427522
132CDK11A0.53987851
133ABL10.53769437
134MAP3K50.53618430
135ROCK20.53229937
136STK380.50886862
137ROCK10.50028794
138SYK0.48480506
139MAP3K110.48453482
140FER0.48019069
141EPHA30.47742013
142OXSR10.47367254
143KDR0.45922701
144NUAK10.45029709
145PRKCD0.44450362
146MAPK130.44060494
147TRIM280.42723959
148PRKD10.41871182
149IRAK40.40405894
150TLK10.40311596
151IRAK10.38570056
152STK160.37897768
153MARK30.37282773
154CAMK2A0.36823134

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.52632734
2Allograft rejection_Homo sapiens_hsa053303.31435491
3Autoimmune thyroid disease_Homo sapiens_hsa053203.23517890
4Type I diabetes mellitus_Homo sapiens_hsa049402.84678352
5Primary immunodeficiency_Homo sapiens_hsa053402.78691991
6Asthma_Homo sapiens_hsa053102.55101144
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.39230025
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.37842255
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.32617754
10Hematopoietic cell lineage_Homo sapiens_hsa046402.25871597
11Synaptic vesicle cycle_Homo sapiens_hsa047212.16522819
12Staphylococcus aureus infection_Homo sapiens_hsa051502.07650390
13Dilated cardiomyopathy_Homo sapiens_hsa054142.00850719
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.85876651
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.69274539
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63381290
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.62299572
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.53284948
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48866640
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.47395651
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46030527
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45214352
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.38244815
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.33714522
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.32019870
26Malaria_Homo sapiens_hsa051441.31413895
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30822587
28Sulfur metabolism_Homo sapiens_hsa009201.28980244
29Olfactory transduction_Homo sapiens_hsa047401.28744147
30Oxytocin signaling pathway_Homo sapiens_hsa049211.28593376
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26691749
32Long-term potentiation_Homo sapiens_hsa047201.21411556
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.21038026
34Focal adhesion_Homo sapiens_hsa045101.20656998
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19967358
36Viral myocarditis_Homo sapiens_hsa054161.19635147
37Gastric acid secretion_Homo sapiens_hsa049711.18376276
38Neurotrophin signaling pathway_Homo sapiens_hsa047221.18278889
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.17975977
40Lysosome_Homo sapiens_hsa041421.17373250
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.17129673
42Fatty acid elongation_Homo sapiens_hsa000621.15002074
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14128901
44Collecting duct acid secretion_Homo sapiens_hsa049661.13635269
45VEGF signaling pathway_Homo sapiens_hsa043701.13603463
46Vibrio cholerae infection_Homo sapiens_hsa051101.13172276
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11348244
48Measles_Homo sapiens_hsa051621.11292305
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10821553
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09122771
51Circadian entrainment_Homo sapiens_hsa047131.07622517
52Osteoclast differentiation_Homo sapiens_hsa043801.07597707
53Glioma_Homo sapiens_hsa052141.06577757
54Legionellosis_Homo sapiens_hsa051341.06403577
55Regulation of autophagy_Homo sapiens_hsa041401.03816116
56Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03254047
57Shigellosis_Homo sapiens_hsa051311.03051867
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02393307
59Platelet activation_Homo sapiens_hsa046111.01365437
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01347563
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99302820
62Insulin secretion_Homo sapiens_hsa049110.99241614
63Insulin signaling pathway_Homo sapiens_hsa049100.98987505
64Endocytosis_Homo sapiens_hsa041440.97205656
65Leishmaniasis_Homo sapiens_hsa051400.96716120
66Salmonella infection_Homo sapiens_hsa051320.96174809
67Cholinergic synapse_Homo sapiens_hsa047250.96026486
68Oxidative phosphorylation_Homo sapiens_hsa001900.95691799
69T cell receptor signaling pathway_Homo sapiens_hsa046600.95590425
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95022448
71Salivary secretion_Homo sapiens_hsa049700.93209109
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93111818
73Phagosome_Homo sapiens_hsa041450.92866381
74GnRH signaling pathway_Homo sapiens_hsa049120.91795884
75Chronic myeloid leukemia_Homo sapiens_hsa052200.91559773
76Proteoglycans in cancer_Homo sapiens_hsa052050.90979404
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.90890228
78Amoebiasis_Homo sapiens_hsa051460.90097671
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89697388
80mTOR signaling pathway_Homo sapiens_hsa041500.88713620
81Tuberculosis_Homo sapiens_hsa051520.87972988
82Dopaminergic synapse_Homo sapiens_hsa047280.87929276
83GABAergic synapse_Homo sapiens_hsa047270.87468591
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.86795762
85Type II diabetes mellitus_Homo sapiens_hsa049300.86406134
86Toxoplasmosis_Homo sapiens_hsa051450.84676480
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.84412422
88Estrogen signaling pathway_Homo sapiens_hsa049150.84409365
89Cardiac muscle contraction_Homo sapiens_hsa042600.84193008
90Renin secretion_Homo sapiens_hsa049240.84090065
91HIF-1 signaling pathway_Homo sapiens_hsa040660.84068748
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.83697814
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83384566
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82888323
95B cell receptor signaling pathway_Homo sapiens_hsa046620.82167689
96Nitrogen metabolism_Homo sapiens_hsa009100.82082391
97Insulin resistance_Homo sapiens_hsa049310.81869150
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81691903
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81343119
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81029742
101Morphine addiction_Homo sapiens_hsa050320.80383369
102Rheumatoid arthritis_Homo sapiens_hsa053230.78809019
103Pancreatic cancer_Homo sapiens_hsa052120.78719209
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78517708
105Arachidonic acid metabolism_Homo sapiens_hsa005900.77364429
106Chemokine signaling pathway_Homo sapiens_hsa040620.77262200
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77230162
108Amphetamine addiction_Homo sapiens_hsa050310.74869717
109Gap junction_Homo sapiens_hsa045400.73058033
110Calcium signaling pathway_Homo sapiens_hsa040200.72529467
111Antigen processing and presentation_Homo sapiens_hsa046120.72297960
112Glucagon signaling pathway_Homo sapiens_hsa049220.72046327
113Prolactin signaling pathway_Homo sapiens_hsa049170.71238113
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69989839
115Proteasome_Homo sapiens_hsa030500.69490707
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69262807
117Protein export_Homo sapiens_hsa030600.69058041
118Renal cell carcinoma_Homo sapiens_hsa052110.68527853
119Pertussis_Homo sapiens_hsa051330.68410909
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.68356522
121MAPK signaling pathway_Homo sapiens_hsa040100.68193222
122Parkinsons disease_Homo sapiens_hsa050120.67903953
123Non-small cell lung cancer_Homo sapiens_hsa052230.67379829
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66460531
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.64880871
126Rap1 signaling pathway_Homo sapiens_hsa040150.64519827
127Endometrial cancer_Homo sapiens_hsa052130.63870064
128ECM-receptor interaction_Homo sapiens_hsa045120.63763791
129African trypanosomiasis_Homo sapiens_hsa051430.62854981
130Acute myeloid leukemia_Homo sapiens_hsa052210.62671495
131Herpes simplex infection_Homo sapiens_hsa051680.61950472
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61896780
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61739972
134Colorectal cancer_Homo sapiens_hsa052100.59210306
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.58922259
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58756730
137TNF signaling pathway_Homo sapiens_hsa046680.57852792
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57445200
139cAMP signaling pathway_Homo sapiens_hsa040240.57112598
140Peroxisome_Homo sapiens_hsa041460.55987788
141Alzheimers disease_Homo sapiens_hsa050100.53646271
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49790092
143Phototransduction_Homo sapiens_hsa047440.48088894
144Pancreatic secretion_Homo sapiens_hsa049720.47395318
145Glycerolipid metabolism_Homo sapiens_hsa005610.46951667
146Influenza A_Homo sapiens_hsa051640.45775423
147Other glycan degradation_Homo sapiens_hsa005110.45114697
148Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45108976
149Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45065064
150Mineral absorption_Homo sapiens_hsa049780.43875534
151Linoleic acid metabolism_Homo sapiens_hsa005910.42183648
152Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39750549
153PPAR signaling pathway_Homo sapiens_hsa033200.38152091
154Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37822711
155Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37759304
156Serotonergic synapse_Homo sapiens_hsa047260.35352868
157Circadian rhythm_Homo sapiens_hsa047100.32315615
158Apoptosis_Homo sapiens_hsa042100.31285441
159Caffeine metabolism_Homo sapiens_hsa002320.29567725
160beta-Alanine metabolism_Homo sapiens_hsa004100.29113319
161Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28922134

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