ARL8A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.81207346
2locomotory exploration behavior (GO:0035641)5.04077944
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.93471429
4layer formation in cerebral cortex (GO:0021819)4.85785992
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.81889414
6synaptic vesicle exocytosis (GO:0016079)4.74182459
7glutamate secretion (GO:0014047)4.50476934
8vocalization behavior (GO:0071625)4.46724502
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.45069206
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.44498554
11neuron cell-cell adhesion (GO:0007158)4.38650917
12regulation of synaptic vesicle exocytosis (GO:2000300)4.34746093
13regulation of synapse structural plasticity (GO:0051823)4.22842381
14protein localization to synapse (GO:0035418)4.12929891
15exploration behavior (GO:0035640)4.03668409
16regulation of glutamate receptor signaling pathway (GO:1900449)3.99423302
17proline transport (GO:0015824)3.95913225
18negative regulation of erythrocyte differentiation (GO:0045647)3.88654185
19dendrite morphogenesis (GO:0048813)3.84034914
20dendritic spine morphogenesis (GO:0060997)3.79039099
21synaptic vesicle docking involved in exocytosis (GO:0016081)3.73128498
22cell migration in hindbrain (GO:0021535)3.72714824
23regulation of synaptic vesicle transport (GO:1902803)3.71070034
24response to peptidoglycan (GO:0032494)3.68690717
25neurotransmitter secretion (GO:0007269)3.62198491
26regulation of neuronal synaptic plasticity (GO:0048168)3.57590152
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.56431745
28regulation of long-term neuronal synaptic plasticity (GO:0048169)3.53563251
29neuron recognition (GO:0008038)3.48782391
30clathrin coat assembly (GO:0048268)3.38864046
31gamma-aminobutyric acid transport (GO:0015812)3.38565055
32negative regulation of microtubule polymerization (GO:0031115)3.33390022
33protein localization to endosome (GO:0036010)3.31769647
34macrophage activation involved in immune response (GO:0002281)3.30560360
35axonal fasciculation (GO:0007413)3.30313937
36sodium ion export (GO:0071436)3.23542933
37postsynaptic membrane organization (GO:0001941)3.22493723
38pyrimidine nucleobase catabolic process (GO:0006208)3.21719969
39neuronal action potential propagation (GO:0019227)3.21710393
40cellular potassium ion homeostasis (GO:0030007)3.20552462
41activation of protein kinase A activity (GO:0034199)3.20168873
42neuromuscular process controlling balance (GO:0050885)3.19316910
43negative regulation of interleukin-12 production (GO:0032695)3.18091634
44negative regulation of cell killing (GO:0031342)3.16352370
45negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.16352370
46modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.10006624
47modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.10006624
48positive regulation by organism of defense response of other organism involved in symbiotic interact3.10006624
49modulation by symbiont of host immune response (GO:0052553)3.10006624
50positive regulation by symbiont of host defense response (GO:0052509)3.10006624
51modulation by symbiont of host defense response (GO:0052031)3.10006624
52synaptic transmission, glutamatergic (GO:0035249)3.09616058
53regulation of T-helper 2 cell differentiation (GO:0045628)3.08915990
54synaptic vesicle endocytosis (GO:0048488)3.08450222
55glutamate receptor signaling pathway (GO:0007215)3.07287360
56glycine transport (GO:0015816)3.04969158
57establishment of mitochondrion localization (GO:0051654)3.03869300
58response to auditory stimulus (GO:0010996)3.02845687
59response to muramyl dipeptide (GO:0032495)3.02371119
60positive regulation of synapse maturation (GO:0090129)2.98653320
61barbed-end actin filament capping (GO:0051016)2.97635747
62regulation of dendritic spine morphogenesis (GO:0061001)2.97311775
63positive regulation of membrane potential (GO:0045838)2.97276916
64positive regulation of cellular amide metabolic process (GO:0034250)2.97251135
65neurotransmitter-gated ion channel clustering (GO:0072578)2.97203935
66organelle transport along microtubule (GO:0072384)2.96784399
67long-term memory (GO:0007616)2.96264690
68neurotransmitter transport (GO:0006836)2.94058699
69axon cargo transport (GO:0008088)2.93122474
70nerve growth factor signaling pathway (GO:0038180)2.92622148
71positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.92239600
72regulation of excitatory postsynaptic membrane potential (GO:0060079)2.90131636
73neuron-neuron synaptic transmission (GO:0007270)2.89508569
74negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.89413085
75lipopolysaccharide-mediated signaling pathway (GO:0031663)2.89362000
76regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.88450254
77neutrophil activation involved in immune response (GO:0002283)2.88273041
78cerebellar Purkinje cell layer development (GO:0021680)2.88041299
79regulation of neurotransmitter secretion (GO:0046928)2.87926885
80central nervous system projection neuron axonogenesis (GO:0021952)2.87575022
81positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.87236191
82establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.86302733
83mitochondrion transport along microtubule (GO:0047497)2.86302733
84positive regulation of synaptic transmission, GABAergic (GO:0032230)2.85710295
85vesicle transport along microtubule (GO:0047496)2.85361130
86regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.84275354
87auditory behavior (GO:0031223)2.84264487
88regulation of synaptic plasticity (GO:0048167)2.82925080
89positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.82195650
90regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.81185954
91nucleobase catabolic process (GO:0046113)2.80799292
92transmission of nerve impulse (GO:0019226)2.80692214
93regulation of vesicle fusion (GO:0031338)2.79756426
94regulation of ARF protein signal transduction (GO:0032012)2.79472552
95mating behavior (GO:0007617)2.77669888
96axon extension (GO:0048675)2.76647066
97positive regulation of axon extension (GO:0045773)2.76041655
98activation of MAPKKK activity (GO:0000185)2.75983609
99regulation of postsynaptic membrane potential (GO:0060078)2.75342656
100cerebellar granule cell differentiation (GO:0021707)2.74993272
101synapse assembly (GO:0007416)2.73207133
102membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.72602094
103regulation of leukocyte degranulation (GO:0043300)2.71082407
104adenosine receptor signaling pathway (GO:0001973)2.70476380
105germinal center formation (GO:0002467)2.69921036
106G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.69872667
107regulation of dendritic spine development (GO:0060998)2.69215847
108positive regulation of dendritic spine development (GO:0060999)2.69202996
109regulation of early endosome to late endosome transport (GO:2000641)2.69181584
110negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.68699863
111regulation of regulated secretory pathway (GO:1903305)2.68494477
112cell communication by electrical coupling (GO:0010644)2.66391706
113negative regulation of axonogenesis (GO:0050771)2.65941266
114innervation (GO:0060384)2.65658791
115regulation of neurotransmitter levels (GO:0001505)2.65228512
116regulation of neurotransmitter transport (GO:0051588)2.62668658
117dopamine receptor signaling pathway (GO:0007212)2.62118755
118adult walking behavior (GO:0007628)2.61683534
119regulation of synaptic transmission, glutamatergic (GO:0051966)2.61665656
120L-amino acid import (GO:0043092)2.61533591
121cytoskeletal anchoring at plasma membrane (GO:0007016)2.60806553
122cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.59480020
123neuromuscular process (GO:0050905)2.59331847
124cerebellar Purkinje cell differentiation (GO:0021702)2.58790860
125cellular response to thyroid hormone stimulus (GO:0097067)2.58216538
126synapse organization (GO:0050808)2.58002763
127regulation of mast cell degranulation (GO:0043304)2.56703831
128detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.56632457
129positive regulation of gamma-delta T cell activation (GO:0046645)2.56416172
130detection of molecule of bacterial origin (GO:0032490)2.50659415
131regulation of myeloid leukocyte mediated immunity (GO:0002886)2.49812121
132NIK/NF-kappaB signaling (GO:0038061)2.48936777
133mannose metabolic process (GO:0006013)2.48758596
134stress fiber assembly (GO:0043149)2.46073111
135amino acid import (GO:0043090)2.45262531
136detection of other organism (GO:0098543)2.44608737
137positive regulation of type 2 immune response (GO:0002830)2.42876373
138positive regulation of protein dephosphorylation (GO:0035307)2.38581892
139positive regulation of Rap GTPase activity (GO:0032854)2.38158821
140regulation of type 2 immune response (GO:0002828)2.36203817
141positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.35533353
142positive regulation of macrophage cytokine production (GO:0060907)2.34087452
143regulation of ARF GTPase activity (GO:0032312)2.33907195
144macrophage activation (GO:0042116)2.33895706
145response to nerve growth factor (GO:1990089)2.32617607
146cellular response to nerve growth factor stimulus (GO:1990090)2.32617607
147regulation of macrophage cytokine production (GO:0010935)2.32097302
148signal complex assembly (GO:0007172)2.31952200
149modulation by symbiont of host cellular process (GO:0044068)2.29815892
150positive regulation of neurotransmitter secretion (GO:0001956)2.29274017
151cell-cell junction maintenance (GO:0045217)2.28909051
152negative regulation of cytokine production involved in immune response (GO:0002719)2.28086213
153detection of bacterium (GO:0016045)2.27474831
154glycosphingolipid catabolic process (GO:0046479)2.26782104
155positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.25410608
156detection of external biotic stimulus (GO:0098581)2.25275904
157positive regulation of regulated secretory pathway (GO:1903307)2.24265286
158regulation of mast cell activation involved in immune response (GO:0033006)2.24118982
159cellular extravasation (GO:0045123)2.23030843
160negative regulation of type 2 immune response (GO:0002829)2.19536851
161epithelial cell differentiation involved in prostate gland development (GO:0060742)2.18102666
162regulation of interferon-beta biosynthetic process (GO:0045357)2.15584442
163positive regulation of leukocyte degranulation (GO:0043302)2.15288024
164immunoglobulin mediated immune response (GO:0016064)2.13171992
165granulocyte activation (GO:0036230)2.12925457
166positive regulation of mast cell activation involved in immune response (GO:0033008)2.11528891
167positive regulation of mast cell degranulation (GO:0043306)2.11528891
168response to acidic pH (GO:0010447)2.11448735
169phagosome maturation (GO:0090382)2.10633861
170leukocyte aggregation (GO:0070486)2.10110298
171myeloid dendritic cell differentiation (GO:0043011)2.09757265
172negative regulation of toll-like receptor signaling pathway (GO:0034122)2.08961149
173myeloid cell activation involved in immune response (GO:0002275)2.08043412
174response to manganese ion (GO:0010042)2.07541414
175response to laminar fluid shear stress (GO:0034616)2.06481304
176negative regulation of leukocyte mediated immunity (GO:0002704)2.05857067
177positive regulation of receptor recycling (GO:0001921)2.05321809
178response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.05151736
179response to host immune response (GO:0052572)2.05151736
180amino sugar catabolic process (GO:0046348)2.04631341

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.76643001
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89585238
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.80537724
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79443660
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.78057827
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63661911
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63661911
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.54645989
9GBX2_23144817_ChIP-Seq_PC3_Human2.49284828
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48463533
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46576970
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44529268
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43761203
14VDR_21846776_ChIP-Seq_THP-1_Human2.42339491
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41623886
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36270860
17REST_21632747_ChIP-Seq_MESCs_Mouse2.34406020
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.29899894
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.29267304
20DROSHA_22980978_ChIP-Seq_HELA_Human2.27979298
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.20679885
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19581862
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.18002401
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.13351414
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13033824
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.09535287
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.04738928
28* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.04693665
29RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03248398
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02643336
31* ELK3_25401928_ChIP-Seq_HUVEC_Human2.02145531
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.97800484
33TP63_17297297_ChIP-ChIP_HaCaT_Human1.95844080
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.94652038
35* TCF7_22412390_ChIP-Seq_EML_Mouse1.93857036
36AR_21572438_ChIP-Seq_LNCaP_Human1.89761767
37VDR_24763502_ChIP-Seq_THP-1_Human1.83640843
38* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81401611
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79250565
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77353231
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.67785741
42* RACK7_27058665_Chip-Seq_MCF-7_Human1.67059772
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61931059
44* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60442132
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59300607
46KDM2B_26808549_Chip-Seq_K562_Human1.59161056
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58964612
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.57732866
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.54104822
50MYC_22102868_ChIP-Seq_BL_Human1.53695977
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.53668232
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.53269855
53IRF8_22096565_ChIP-ChIP_GC-B_Human1.52656334
54* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.50770039
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48205430
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45555214
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42115861
58SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42029578
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41492140
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41093367
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39791945
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38998731
63SPI1_23127762_ChIP-Seq_K562_Human1.37980633
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37972732
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37556516
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.36715922
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.35583844
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35456432
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33847527
70TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33810340
71MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33199592
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31822415
73* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31161596
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30861616
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.30737977
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.30579827
77WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29960375
78RUNX1_22412390_ChIP-Seq_EML_Mouse1.29705745
79RING1B_27294783_Chip-Seq_NPCs_Mouse1.29225810
80EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28130794
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27323212
82* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26563402
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26257853
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25201257
85SMC4_20622854_ChIP-Seq_HELA_Human1.23756269
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23354929
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22494049
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21857126
89TRIM28_21343339_ChIP-Seq_HEK293_Human1.19631567
90* MAF_26560356_Chip-Seq_TH1_Human1.19473329
91P68_20966046_ChIP-Seq_HELA_Human1.18431862
92SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18064979
93RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16784997
94CREB1_26743006_Chip-Seq_LNCaP_Human1.16111068
95ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15015205
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14777130
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14564388
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.14003459
99PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13911478
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13907261
101TET1_21451524_ChIP-Seq_MESCs_Mouse1.13559259
102SMAD_19615063_ChIP-ChIP_OVARY_Human1.13454104
103SMAD4_21799915_ChIP-Seq_A2780_Human1.12990369
104* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12238748
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12196925
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11806755
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11230693
108RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11164926
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10731088
110AHR_22903824_ChIP-Seq_MCF-7_Human1.10099217
111SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09630946
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08289871
113* UTX_26944678_Chip-Seq_JUKART_Human1.07103562
114AR_19668381_ChIP-Seq_PC3_Human1.06993589
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06955652
116CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06205385
117CLOCK_20551151_ChIP-Seq_293T_Human1.05441181
118ZNF274_21170338_ChIP-Seq_K562_Hela1.05215534
119STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03719936
120* MAF_26560356_Chip-Seq_TH2_Human1.03565691
121P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02230983
122ARNT_22903824_ChIP-Seq_MCF-7_Human1.01888262
123ESR1_21235772_ChIP-Seq_MCF-7_Human1.01840491
124CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01215386
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00624342
126OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99970343
127CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99078068
128SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98285385
129ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97874379
130VDR_24787735_ChIP-Seq_THP-1_Human0.97707003
131YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97144542
132STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96878599
133NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96730401
134BCOR_27268052_Chip-Seq_Bcells_Human0.95950191
135* TET1_21490601_ChIP-Seq_MESCs_Mouse0.95770416
136SMAD4_21741376_ChIP-Seq_HESCs_Human0.95618437
137GATA1_19941826_ChIP-Seq_K562_Human0.95588353
138* TP53_20018659_ChIP-ChIP_R1E_Mouse0.93856950
139SMAD3_21741376_ChIP-Seq_ESCs_Human0.93763371
140SMAD3_21741376_ChIP-Seq_EPCs_Human0.93674095
141THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93375309
142KDM2B_26808549_Chip-Seq_JURKAT_Human0.92292222
143* KDM2B_26808549_Chip-Seq_DND41_Human0.91404422
144LXR_22292898_ChIP-Seq_THP-1_Human0.91098097
145STAT3_23295773_ChIP-Seq_U87_Human0.90991009
146SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89470036
147AR_25329375_ChIP-Seq_VCAP_Human0.89341218
148TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87577767
149* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87155300
150CBX2_27304074_Chip-Seq_ESCs_Mouse0.86531891
151ESR2_21235772_ChIP-Seq_MCF-7_Human0.86426953
152SMAD3_21741376_ChIP-Seq_HESCs_Human0.86240149
153SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85466381
154TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84463612
155CTCF_27219007_Chip-Seq_Bcells_Human0.83154564
156DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82087509
157RXR_22108803_ChIP-Seq_LS180_Human0.81648189
158P300_19829295_ChIP-Seq_ESCs_Human0.81146818
159CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.81128470
160TP53_16413492_ChIP-PET_HCT116_Human0.80667424
161PIAS1_25552417_ChIP-Seq_VCAP_Human0.79863849
162RNF2_27304074_Chip-Seq_NSC_Mouse0.79761242
163MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79544432

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.20197446
2MP0004270_analgesia4.12092817
3MP0003635_abnormal_synaptic_transmissio3.77445565
4MP0003880_abnormal_central_pattern3.69386357
5MP0004858_abnormal_nervous_system3.22290041
6MP0002063_abnormal_learning/memory/cond3.06231143
7MP0003436_decreased_susceptibility_to2.96456624
8MP0002064_seizures2.88937730
9MP0009745_abnormal_behavioral_response2.86513377
10MP0002734_abnormal_mechanical_nocicepti2.80501812
11MP0001968_abnormal_touch/_nociception2.78230136
12MP0005423_abnormal_somatic_nervous2.71020287
13MP0009046_muscle_twitch2.62091442
14MP0003329_amyloid_beta_deposits2.52462433
15MP0002733_abnormal_thermal_nociception2.50812848
16MP0009840_abnormal_foam_cell2.48705263
17MP0002572_abnormal_emotion/affect_behav2.48579637
18MP0002735_abnormal_chemical_nociception2.45189236
19MP0000778_abnormal_nervous_system2.44707573
20MP0006082_CNS_inflammation2.32341795
21MP0003300_gastrointestinal_ulcer2.23939603
22MP0001970_abnormal_pain_threshold2.22654919
23MP0003191_abnormal_cellular_cholesterol2.22390682
24MP0009278_abnormal_bone_marrow2.22020990
25MP0001486_abnormal_startle_reflex2.17924892
26MP0009780_abnormal_chondrocyte_physiolo2.13874395
27MP0001440_abnormal_grooming_behavior2.13779105
28MP0002272_abnormal_nervous_system2.11968909
29MP0002736_abnormal_nociception_after2.09353972
30MP0003724_increased_susceptibility_to2.09077790
31MP0002419_abnormal_innate_immunity2.06216331
32MP0003705_abnormal_hypodermis_morpholog1.98650565
33MP0004811_abnormal_neuron_physiology1.97694984
34MP0002148_abnormal_hypersensitivity_rea1.92757531
35MP0002184_abnormal_innervation1.86635647
36MP0000955_abnormal_spinal_cord1.83840343
37MP0004885_abnormal_endolymph1.81075526
38MP0001501_abnormal_sleep_pattern1.80083030
39MP0005025_abnormal_response_to1.79322871
40MP0005000_abnormal_immune_tolerance1.78410628
41MP0008569_lethality_at_weaning1.75770024
42MP0009785_altered_susceptibility_to1.74558613
43MP0002067_abnormal_sensory_capabilities1.73706421
44MP0005451_abnormal_body_composition1.72150988
45MP0002909_abnormal_adrenal_gland1.71928428
46MP0002822_catalepsy1.70312195
47MP0001533_abnormal_skeleton_physiology1.65149870
48MP0000920_abnormal_myelination1.65122708
49MP0008260_abnormal_autophagy1.65080110
50MP0000343_altered_response_to1.62910554
51MP0003634_abnormal_glial_cell1.60588496
52MP0004947_skin_inflammation1.59499256
53MP0002557_abnormal_social/conspecific_i1.58674188
54MP0006276_abnormal_autonomic_nervous1.58467138
55MP0004924_abnormal_behavior1.58428081
56MP0005386_behavior/neurological_phenoty1.58428081
57MP0005387_immune_system_phenotype1.57962182
58MP0001790_abnormal_immune_system1.57962182
59MP0002998_abnormal_bone_remodeling1.54410409
60MP0002882_abnormal_neuron_morphology1.53441582
61MP0005623_abnormal_meninges_morphology1.52067672
62MP0000604_amyloidosis1.49161919
63MP0000569_abnormal_digit_pigmentation1.48002051
64MP0003303_peritoneal_inflammation1.47349497
65MP0001835_abnormal_antigen_presentation1.45204095
66MP0003453_abnormal_keratinocyte_physiol1.43401191
67MP0003172_abnormal_lysosome_physiology1.43145894
68MP0001348_abnormal_lacrimal_gland1.42916475
69MP0002066_abnormal_motor_capabilities/c1.42862839
70MP0005166_decreased_susceptibility_to1.42007164
71MP0003633_abnormal_nervous_system1.39670217
72MP0003690_abnormal_glial_cell1.37856623
73MP0003879_abnormal_hair_cell1.34225597
74MP0002723_abnormal_immune_serum1.29772469
75MP0002452_abnormal_antigen_presenting1.28089040
76MP0009764_decreased_sensitivity_to1.25188702
77MP0003631_nervous_system_phenotype1.22865789
78MP0002152_abnormal_brain_morphology1.21847596
79MP0005671_abnormal_response_to1.21272161
80MP0001849_ear_inflammation1.20973781
81MP0000685_abnormal_immune_system1.19742133
82MP0002420_abnormal_adaptive_immunity1.18360925
83MP0001905_abnormal_dopamine_level1.17942649
84MP0005397_hematopoietic_system_phenotyp1.17588598
85MP0001545_abnormal_hematopoietic_system1.17588598
86MP0001819_abnormal_immune_cell1.17366283
87MP0001800_abnormal_humoral_immune1.11829371
88MP0004142_abnormal_muscle_tone1.10941772
89MP0003828_pulmonary_edema1.10778239
90MP0003448_altered_tumor_morphology1.10101846
91MP0000858_altered_metastatic_potential1.09984898
92MP0003075_altered_response_to1.08444799
93MP0003279_aneurysm1.08232943
94MP0005464_abnormal_platelet_physiology1.08035090
95MP0003632_abnormal_nervous_system1.06718027
96MP0004510_myositis1.04341398
97MP0001502_abnormal_circadian_rhythm1.03910427
98MP0005409_darkened_coat_color1.03373209
99MP0004742_abnormal_vestibular_system1.02386050
100MP0002229_neurodegeneration1.01117541
101MP0001984_abnormal_olfaction1.00544109
102MP0001299_abnormal_eye_distance/0.98474745
103MP0001845_abnormal_inflammatory_respons0.95214482
104MP0005645_abnormal_hypothalamus_physiol0.94958860
105MP0001853_heart_inflammation0.94611647
106MP0002332_abnormal_exercise_endurance0.93712991
107MP0010386_abnormal_urinary_bladder0.92972346
108MP0008961_abnormal_basal_metabolism0.90965846
109MP0005076_abnormal_cell_differentiation0.89737654
110MP0001958_emphysema0.89262748
111MP0005310_abnormal_salivary_gland0.89057305
112MP0010155_abnormal_intestine_physiology0.88238193
113MP0002405_respiratory_system_inflammati0.87477148
114MP0002877_abnormal_melanocyte_morpholog0.87004572
115MP0008469_abnormal_protein_level0.85380221
116MP0003122_maternal_imprinting0.85284733
117MP0002090_abnormal_vision0.84399480
118MP0005390_skeleton_phenotype0.84227340
119MP0002069_abnormal_eating/drinking_beha0.82675184
120MP0003283_abnormal_digestive_organ0.80989011
121MP0000751_myopathy0.80347024
122MP0008874_decreased_physiological_sensi0.79465610
123MP0002752_abnormal_somatic_nervous0.78662625
124MP0003787_abnormal_imprinting0.77429032
125MP0001529_abnormal_vocalization0.75309979
126MP0000716_abnormal_immune_system0.75251806
127MP0001851_eye_inflammation0.74781491
128MP0001177_atelectasis0.74604366
129MP0003861_abnormal_nervous_system0.74272053
130MP0005666_abnormal_adipose_tissue0.73287298
131MP0003123_paternal_imprinting0.72865746
132MP0003566_abnormal_cell_adhesion0.69053714
133MP0008004_abnormal_stomach_pH0.69017221
134MP0005165_increased_susceptibility_to0.68838364
135MP0005646_abnormal_pituitary_gland0.68288011
136MP0001963_abnormal_hearing_physiology0.67001215
137MP0005499_abnormal_olfactory_system0.66152226
138MP0005394_taste/olfaction_phenotype0.66152226
139MP0005167_abnormal_blood-brain_barrier0.65526488
140MP0000534_abnormal_ureter_morphology0.62682512
141MP0005535_abnormal_body_temperature0.59701555
142MP0000013_abnormal_adipose_tissue0.59400533
143MP0003091_abnormal_cell_migration0.58902527
144MP0002653_abnormal_ependyma_morphology0.58662959
145MP0000631_abnormal_neuroendocrine_gland0.58191287
146MP0001943_abnormal_respiration0.56844004
147MP0004085_abnormal_heartbeat0.56401647
148MP0002089_abnormal_postnatal_growth/wei0.55511933
149MP0000747_muscle_weakness0.55340430
150MP0004233_abnormal_muscle_weight0.55015979
151MP0005058_abnormal_lysosome_morphology0.54882302
152MP0004130_abnormal_muscle_cell0.54848193
153MP0002751_abnormal_autonomic_nervous0.52097815
154MP0010769_abnormal_survival0.51670372
155MP0004145_abnormal_muscle_electrophysio0.51235184
156MP0003183_abnormal_peptide_metabolism0.50727551
157MP0010770_preweaning_lethality0.48573451
158MP0002082_postnatal_lethality0.48573451
159MP0008872_abnormal_physiological_respon0.48312879

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.89345535
2Supranuclear gaze palsy (HP:0000605)4.86289118
3Abnormality of glycolipid metabolism (HP:0010969)4.61044306
4Abnormality of liposaccharide metabolism (HP:0010968)4.61044306
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.61044306
6Focal motor seizures (HP:0011153)4.41491954
7Visual hallucinations (HP:0002367)4.31449671
8Focal seizures (HP:0007359)4.21382065
9Mutism (HP:0002300)4.15493784
10Neurofibrillary tangles (HP:0002185)4.08480239
11Action tremor (HP:0002345)3.81883920
12Cerebral inclusion bodies (HP:0100314)3.78288703
13Ankle clonus (HP:0011448)3.67435520
14Epileptic encephalopathy (HP:0200134)3.56205590
15Termporal pattern (HP:0011008)3.50566030
16Insidious onset (HP:0003587)3.50566030
17Abnormality of macrophages (HP:0004311)3.39752216
18Eczematoid dermatitis (HP:0000976)3.37879229
19Progressive cerebellar ataxia (HP:0002073)3.35041177
20Abnormality of the corticospinal tract (HP:0002492)3.34403876
21Dysostosis multiplex (HP:0000943)3.30469186
22Papilledema (HP:0001085)3.25213676
23Atonic seizures (HP:0010819)3.14160449
24Loss of speech (HP:0002371)3.11224510
25Limb dystonia (HP:0002451)3.03500312
26Megalencephaly (HP:0001355)2.99775963
27Axonal loss (HP:0003447)2.91288608
28Diplopia (HP:0000651)2.87350138
29Abnormality of binocular vision (HP:0011514)2.87350138
30Nuclear cataract (HP:0100018)2.84068622
31Absence seizures (HP:0002121)2.83859215
32Systemic lupus erythematosus (HP:0002725)2.83112315
33Urinary bladder sphincter dysfunction (HP:0002839)2.82687510
34Increased neuronal autofluorescent lipopigment (HP:0002074)2.81684737
35Recurrent bacterial skin infections (HP:0005406)2.81659004
36Recurrent abscess formation (HP:0002722)2.81490393
37Abnormal eating behavior (HP:0100738)2.81162807
38Apathy (HP:0000741)2.79687347
39Akinesia (HP:0002304)2.79491999
40Amyotrophic lateral sclerosis (HP:0007354)2.78022041
41Generalized tonic-clonic seizures (HP:0002069)2.77027967
42Urinary urgency (HP:0000012)2.76604335
43Spastic gait (HP:0002064)2.68852176
44Depression (HP:0000716)2.65937355
45Polyphagia (HP:0002591)2.64542530
46Genetic anticipation (HP:0003743)2.63916024
47Dialeptic seizures (HP:0011146)2.63403766
48Amyloidosis (HP:0011034)2.60018984
49Dysmetria (HP:0001310)2.57492263
50Abnormality of polysaccharide metabolism (HP:0011012)2.55936023
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.55936023
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.55936023
53Neuronal loss in central nervous system (HP:0002529)2.55671996
54Broad-based gait (HP:0002136)2.55191272
55Orchitis (HP:0100796)2.54149476
56Poor eye contact (HP:0000817)2.51736194
57Obstructive sleep apnea (HP:0002870)2.50996364
58Diminished motivation (HP:0000745)2.50944436
59Myositis (HP:0100614)2.48182906
60Torticollis (HP:0000473)2.47890085
61Impaired vibration sensation in the lower limbs (HP:0002166)2.47351359
62Inappropriate behavior (HP:0000719)2.46905255
63Febrile seizures (HP:0002373)2.45875483
64Drooling (HP:0002307)2.45240407
65Excessive salivation (HP:0003781)2.45240407
66Amblyopia (HP:0000646)2.44667090
67Postural instability (HP:0002172)2.43781865
68Urinary glycosaminoglycan excretion (HP:0003541)2.43257589
69Mucopolysacchariduria (HP:0008155)2.43257589
70Lower limb muscle weakness (HP:0007340)2.41205811
71Mediastinal lymphadenopathy (HP:0100721)2.40179946
72Agitation (HP:0000713)2.38300632
73Impaired social interactions (HP:0000735)2.37260080
74Abnormal social behavior (HP:0012433)2.37260080
75Hemiparesis (HP:0001269)2.35805683
76Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.35657983
77Pheochromocytoma (HP:0002666)2.33502674
78Recurrent gram-negative bacterial infections (HP:0005420)2.32424426
79Intention tremor (HP:0002080)2.32245030
80Progressive inability to walk (HP:0002505)2.29921825
81Dysdiadochokinesis (HP:0002075)2.29884138
82Hyperacusis (HP:0010780)2.27352117
83Truncal ataxia (HP:0002078)2.24867373
84Degeneration of the lateral corticospinal tracts (HP:0002314)2.24664773
85Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.24664773
86Rapidly progressive (HP:0003678)2.24494872
87Dementia (HP:0000726)2.21182909
88Cellulitis (HP:0100658)2.20561597
89Retrobulbar optic neuritis (HP:0100654)2.19621772
90Optic neuritis (HP:0100653)2.19621772
91Vacuolated lymphocytes (HP:0001922)2.17766311
92Stereotypic behavior (HP:0000733)2.17450216
93Anxiety (HP:0000739)2.17402899
94Increased cerebral lipofuscin (HP:0011813)2.15360508
95Segmental peripheral demyelination/remyelination (HP:0003481)2.14830681
96Lower limb amyotrophy (HP:0007210)2.14727101
97Focal dystonia (HP:0004373)2.14001399
98Disinhibition (HP:0000734)2.10422299
99Interstitial pulmonary disease (HP:0006530)2.09784812
100Hyperparathyroidism (HP:0000843)2.09227767
101Insomnia (HP:0100785)2.08247170
102Cerebral aneurysm (HP:0004944)2.07785788
103Peripheral hypomyelination (HP:0007182)2.02796599
104Vertebral compression fractures (HP:0002953)2.02470036
105Morphological abnormality of the pyramidal tract (HP:0002062)2.02002088
106Abnormality of the lower motor neuron (HP:0002366)2.01261703
107Hypercortisolism (HP:0001578)1.97455593
108Slow saccadic eye movements (HP:0000514)1.97235788
109Craniofacial dystonia (HP:0012179)1.96922215
110Gingivitis (HP:0000230)1.96914707
111Obstructive lung disease (HP:0006536)1.96331254
112Chronic obstructive pulmonary disease (HP:0006510)1.96331254
113Purpura (HP:0000979)1.95792634
114Polygenic inheritance (HP:0010982)1.94152221
115Achilles tendon contracture (HP:0001771)1.93323649
116Onion bulb formation (HP:0003383)1.93307942
117Neuroendocrine neoplasm (HP:0100634)1.93121767
118Personality changes (HP:0000751)1.91736718
119Distal lower limb muscle weakness (HP:0009053)1.91702624
120Bradykinesia (HP:0002067)1.91155135
121Ulnar claw (HP:0001178)1.91030304
122Macroorchidism (HP:0000053)1.90866511
123Hammertoe (HP:0001765)1.90697966
124Increased IgE level (HP:0003212)1.90436304
125Hypoplasia of the brainstem (HP:0002365)1.89572713
126Aplasia/Hypoplasia of the brainstem (HP:0007362)1.89572713
127EEG with generalized epileptiform discharges (HP:0011198)1.88123803
128Hypsarrhythmia (HP:0002521)1.88060444
129Aqueductal stenosis (HP:0002410)1.87900970
130Abnormality of the periventricular white matter (HP:0002518)1.86133729
131Gaze-evoked nystagmus (HP:0000640)1.86020554
132Postural tremor (HP:0002174)1.85269415
133Epileptiform EEG discharges (HP:0011182)1.85178612
134Absent speech (HP:0001344)1.84858354
135Hemiplegia (HP:0002301)1.83746738
136Asymmetric septal hypertrophy (HP:0001670)1.82786972
137Upper limb amyotrophy (HP:0009129)1.81731697
138Distal upper limb amyotrophy (HP:0007149)1.81731697
139Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.81231471
140Clonus (HP:0002169)1.81211140
141Stomatitis (HP:0010280)1.81059307
142Rigidity (HP:0002063)1.79664687
143Generalized myoclonic seizures (HP:0002123)1.79005030
144Fetal akinesia sequence (HP:0001989)1.78852426
145Spontaneous hematomas (HP:0007420)1.78406423
146Distal lower limb amyotrophy (HP:0008944)1.78042471
147Failure to thrive in infancy (HP:0001531)1.77939503
148J-shaped sella turcica (HP:0002680)1.77182754
149Bronchomalacia (HP:0002780)1.76980624
150Hyperventilation (HP:0002883)1.75939691
151Progressive neurologic deterioration (HP:0002344)1.75637105
152Hypoventilation (HP:0002791)1.75375034
153Pointed chin (HP:0000307)1.74978002
154Memory impairment (HP:0002354)1.72921496
155Pathologic fracture (HP:0002756)1.72673021
156Foot dorsiflexor weakness (HP:0009027)1.72493539
157Decreased motor nerve conduction velocity (HP:0003431)1.70297542
158Centrally nucleated skeletal muscle fibers (HP:0003687)1.70055955
159Thin bony cortex (HP:0002753)1.69729154
160Urinary incontinence (HP:0000020)1.68750839
161Upper motor neuron abnormality (HP:0002127)1.68162696
162Annular pancreas (HP:0001734)1.67227085
163Abnormality of the Achilles tendon (HP:0005109)1.64313745
164Glomerulonephritis (HP:0000099)1.62487747
165Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.62019422
166Global brain atrophy (HP:0002283)1.60924182
167Increased serum ferritin (HP:0003281)1.60512534

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.06826337
2MAP3K93.99174253
3NTRK32.98523645
4MINK12.58506701
5NTRK12.51582662
6PAK62.45305013
7ERN12.40589872
8KSR22.39507446
9IRAK32.21553254
10EPHA42.16599065
11NTRK22.14998062
12MAP3K112.10966694
13MAP3K42.10313884
14DAPK21.96750723
15CAMKK11.93623581
16LATS21.82543482
17TAOK21.80361854
18PHKG11.77529087
19PHKG21.77529087
20PRKD31.62871967
21MAP2K31.59008443
22LIMK11.56802802
23SIK11.55628064
24SIK21.51590227
25TYRO31.51383515
26MAP2K71.50642367
27CDK51.48993713
28GRK51.48228271
29MAP3K21.45166788
30TBK11.44303898
31NME21.42955255
32KSR11.39477588
33MAP3K31.34859714
34RIPK41.34238327
35BLK1.32834990
36UHMK11.32632081
37MAP2K41.30763889
38MAPK131.29263518
39MAP3K141.29069496
40CAMKK21.29061493
41CSK1.21990285
42PLK21.20313284
43MOS1.18517579
44RET1.16456240
45TAOK11.15820986
46MAP4K11.15532110
47TYK21.15359980
48IRAK41.14545377
49DYRK21.14066814
50PRPF4B1.12172013
51ARAF1.10954628
52CSNK1G21.09371321
53ICK1.08864878
54MAP3K121.08058210
55PIM21.07837056
56CDK141.05663975
57CAMK1G1.03830838
58PAK31.03435505
59SIK31.03209791
60ZAP700.99947209
61CDK150.98720260
62TNK20.98509814
63CDK180.97646873
64TRIB30.96035568
65ALK0.95200540
66SMG10.89714981
67CDK190.88810127
68MARK20.87287102
69SCYL20.86764477
70CDK11A0.85759265
71CASK0.85385707
72PRKCG0.85104232
73STK110.84490536
74FGR0.82068901
75PRKCH0.81899394
76GRK70.81827255
77DDR20.80546364
78IRAK20.80497121
79TTN0.79869862
80PKN10.79579802
81PNCK0.79564507
82RIPK10.78806948
83ABL20.78435895
84FES0.77946060
85DAPK10.77299077
86PRKD20.75967795
87STK380.74245219
88LMTK20.72787310
89WNK10.71806961
90CAMK2A0.71478527
91OXSR10.68893377
92ERBB30.68735515
93STK390.67644517
94PRKCZ0.67092516
95SGK30.66972683
96TESK20.66728431
97MAP3K60.66591004
98JAK20.66522141
99CSNK1G30.65417330
100DYRK1B0.65086295
101SGK4940.64485997
102SGK2230.64485997
103RPS6KA20.63864014
104FYN0.63509316
105BMX0.63374548
106TESK10.62485008
107CSNK1A1L0.62391130
108IKBKE0.62378583
109MAP3K130.61870256
110PKN20.61658127
111JAK10.61633691
112HIPK20.61382684
113RPS6KL10.61218095
114RPS6KC10.61218095
115MAPK40.61148085
116HCK0.60556523
117FGFR40.59701104
118CAMK2B0.59397922
119PDPK10.56668974
120PTK60.56587191
121JAK30.56335262
122TGFBR20.55969440
123MAP3K10.55895976
124ROCK20.54711165
125DYRK1A0.54411353
126PDGFRA0.54242991
127DAPK30.52854331
128DMPK0.51545746
129TNIK0.51394770
130PRKCE0.50065857
131SYK0.49475707
132PRKG20.49052556
133MAP2K10.48614674
134EPHB20.47420819
135CAMK2G0.47364958
136PTK2B0.46824436
137PDK10.46715707
138EPHB10.45933829
139MATK0.45922389
140CAMK1D0.45792687
141CAMK10.45469152
142CSF1R0.45300366
143PTK20.44852082
144SGK10.44490279
145CDC42BPA0.42978410
146RAF10.39968950
147MAPK120.38613221

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.89815520
2Nicotine addiction_Homo sapiens_hsa050332.27169091
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.25875805
4Other glycan degradation_Homo sapiens_hsa005112.10400424
5GABAergic synapse_Homo sapiens_hsa047272.10112516
6Osteoclast differentiation_Homo sapiens_hsa043802.09218741
7Olfactory transduction_Homo sapiens_hsa047402.07983937
8Circadian entrainment_Homo sapiens_hsa047132.04018042
9Glutamatergic synapse_Homo sapiens_hsa047242.00853472
10Long-term potentiation_Homo sapiens_hsa047201.95784549
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.90795853
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.86081256
13Dopaminergic synapse_Homo sapiens_hsa047281.84646337
14Morphine addiction_Homo sapiens_hsa050321.84237144
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.82546298
16Cholinergic synapse_Homo sapiens_hsa047251.76913505
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.76429057
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.65887105
19Salivary secretion_Homo sapiens_hsa049701.64638483
20Amphetamine addiction_Homo sapiens_hsa050311.63824331
21Leishmaniasis_Homo sapiens_hsa051401.60415540
22Gastric acid secretion_Homo sapiens_hsa049711.57729448
23Axon guidance_Homo sapiens_hsa043601.56903361
24Long-term depression_Homo sapiens_hsa047301.50680450
25Insulin secretion_Homo sapiens_hsa049111.44878457
26Cocaine addiction_Homo sapiens_hsa050301.44734173
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44531157
28Serotonergic synapse_Homo sapiens_hsa047261.40747762
29Gap junction_Homo sapiens_hsa045401.40472917
30Glioma_Homo sapiens_hsa052141.37566087
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.36098220
32GnRH signaling pathway_Homo sapiens_hsa049121.35425483
33Oxytocin signaling pathway_Homo sapiens_hsa049211.35153605
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33943132
35Renin secretion_Homo sapiens_hsa049241.30466335
36Staphylococcus aureus infection_Homo sapiens_hsa051501.29571265
37Acute myeloid leukemia_Homo sapiens_hsa052211.29402258
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27642670
39Collecting duct acid secretion_Homo sapiens_hsa049661.26669125
40ErbB signaling pathway_Homo sapiens_hsa040121.25882882
41TNF signaling pathway_Homo sapiens_hsa046681.23845678
42Estrogen signaling pathway_Homo sapiens_hsa049151.23527391
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.22661842
44Malaria_Homo sapiens_hsa051441.22630461
45Dorso-ventral axis formation_Homo sapiens_hsa043201.21174485
46Pertussis_Homo sapiens_hsa051331.18875626
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17629788
48Type II diabetes mellitus_Homo sapiens_hsa049301.15642826
49Taste transduction_Homo sapiens_hsa047421.12178169
50Neurotrophin signaling pathway_Homo sapiens_hsa047221.09329622
51Toxoplasmosis_Homo sapiens_hsa051451.06420550
52Notch signaling pathway_Homo sapiens_hsa043301.05699415
53Phospholipase D signaling pathway_Homo sapiens_hsa040721.04828403
54Renal cell carcinoma_Homo sapiens_hsa052111.01189264
55cAMP signaling pathway_Homo sapiens_hsa040240.98332546
56VEGF signaling pathway_Homo sapiens_hsa043700.98080379
57Melanogenesis_Homo sapiens_hsa049160.97968489
58Vibrio cholerae infection_Homo sapiens_hsa051100.97820602
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97367430
60Calcium signaling pathway_Homo sapiens_hsa040200.96895573
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.96262755
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95493727
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93960552
64Endometrial cancer_Homo sapiens_hsa052130.93442222
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91739504
66Endocytosis_Homo sapiens_hsa041440.89848435
67Hepatitis C_Homo sapiens_hsa051600.89438958
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.87795201
69Bladder cancer_Homo sapiens_hsa052190.87772510
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87684002
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86938300
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86637080
73Influenza A_Homo sapiens_hsa051640.83899444
74Choline metabolism in cancer_Homo sapiens_hsa052310.82761386
75African trypanosomiasis_Homo sapiens_hsa051430.82296324
76Shigellosis_Homo sapiens_hsa051310.81937069
77MAPK signaling pathway_Homo sapiens_hsa040100.81553010
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80435319
79Prion diseases_Homo sapiens_hsa050200.80025103
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79830891
81Legionellosis_Homo sapiens_hsa051340.79811833
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.79707733
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78733509
84Ras signaling pathway_Homo sapiens_hsa040140.77559022
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.76909177
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76616087
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76489718
88mTOR signaling pathway_Homo sapiens_hsa041500.75851677
89Hepatitis B_Homo sapiens_hsa051610.74047664
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73901720
91T cell receptor signaling pathway_Homo sapiens_hsa046600.73785456
92Colorectal cancer_Homo sapiens_hsa052100.73336496
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.73218798
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72780230
95Chemokine signaling pathway_Homo sapiens_hsa040620.72337133
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72071825
97Allograft rejection_Homo sapiens_hsa053300.71708712
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71130247
99Rap1 signaling pathway_Homo sapiens_hsa040150.70524925
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69125740
101Dilated cardiomyopathy_Homo sapiens_hsa054140.68638744
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68321597
103Lysosome_Homo sapiens_hsa041420.65831664
104Salmonella infection_Homo sapiens_hsa051320.64759620
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64300866
106Phagosome_Homo sapiens_hsa041450.64050596
107Apoptosis_Homo sapiens_hsa042100.63785223
108Nitrogen metabolism_Homo sapiens_hsa009100.63686530
109Non-small cell lung cancer_Homo sapiens_hsa052230.63310300
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62768840
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61877011
112Graft-versus-host disease_Homo sapiens_hsa053320.61221915
113Platelet activation_Homo sapiens_hsa046110.59171588
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58085500
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56608604
116Thyroid hormone synthesis_Homo sapiens_hsa049180.56311967
117Pancreatic secretion_Homo sapiens_hsa049720.55444638
118Oocyte meiosis_Homo sapiens_hsa041140.54876823
119Insulin signaling pathway_Homo sapiens_hsa049100.53965726
120Prolactin signaling pathway_Homo sapiens_hsa049170.53650905
121Tuberculosis_Homo sapiens_hsa051520.52099234
122Amoebiasis_Homo sapiens_hsa051460.51753836
123Pancreatic cancer_Homo sapiens_hsa052120.51131945
124Cardiac muscle contraction_Homo sapiens_hsa042600.49795269
125Rheumatoid arthritis_Homo sapiens_hsa053230.49160541
126Chronic myeloid leukemia_Homo sapiens_hsa052200.48503082
127Wnt signaling pathway_Homo sapiens_hsa043100.47819829
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46960167
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46780090
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45911400
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45891156
132B cell receptor signaling pathway_Homo sapiens_hsa046620.45801094
133Proteoglycans in cancer_Homo sapiens_hsa052050.45139326

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