ARL8B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.40521437
2regulation of vitamin D biosynthetic process (GO:0060556)5.07297899
3presynaptic membrane organization (GO:0097090)4.87777675
4synaptic vesicle docking involved in exocytosis (GO:0016081)4.71726742
5regulation of synaptic vesicle exocytosis (GO:2000300)4.69138969
6glutamate secretion (GO:0014047)4.58715876
7negative regulation of dendrite morphogenesis (GO:0050774)4.48332515
8transferrin transport (GO:0033572)4.46133470
9regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.35673482
10neuron cell-cell adhesion (GO:0007158)4.27783280
11synaptic vesicle endocytosis (GO:0048488)4.26430711
12response to peptidoglycan (GO:0032494)4.23993154
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.19407470
14presynaptic membrane assembly (GO:0097105)4.18829286
15energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.18755146
16ATP hydrolysis coupled proton transport (GO:0015991)4.18755146
17regulation of synaptic vesicle transport (GO:1902803)4.18307563
18ferric iron transport (GO:0015682)4.17546078
19trivalent inorganic cation transport (GO:0072512)4.17546078
20neuronal action potential propagation (GO:0019227)4.17443929
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.17007052
22vocalization behavior (GO:0071625)4.16585422
23glycosphingolipid catabolic process (GO:0046479)4.01521351
24negative regulation of interleukin-12 production (GO:0032695)3.99620592
25neutrophil activation involved in immune response (GO:0002283)3.96659005
26regulation of vitamin metabolic process (GO:0030656)3.96394067
27negative regulation of synaptic transmission, GABAergic (GO:0032229)3.90425584
28regulation of glutamate receptor signaling pathway (GO:1900449)3.89893574
29lipopolysaccharide-mediated signaling pathway (GO:0031663)3.88198219
30long-term synaptic potentiation (GO:0060291)3.84623339
31positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.83869133
32cellular response to thyroid hormone stimulus (GO:0097067)3.83649558
33startle response (GO:0001964)3.75460976
34phagosome maturation (GO:0090382)3.73391710
35synaptic vesicle maturation (GO:0016188)3.73098620
36regulation of neuronal synaptic plasticity (GO:0048168)3.72990758
37neuron-neuron synaptic transmission (GO:0007270)3.70630059
38protein localization to synapse (GO:0035418)3.70127442
39neurotransmitter-gated ion channel clustering (GO:0072578)3.69315873
40neurotransmitter secretion (GO:0007269)3.66370399
41oligosaccharide catabolic process (GO:0009313)3.64146103
42regulation of chronic inflammatory response (GO:0002676)3.61611242
43regulation of fever generation (GO:0031620)3.61143014
44glycolipid catabolic process (GO:0019377)3.59662670
45gamma-aminobutyric acid signaling pathway (GO:0007214)3.54898221
46positive regulation of heat generation (GO:0031652)3.53095185
47ionotropic glutamate receptor signaling pathway (GO:0035235)3.50106022
48regulation of long-term neuronal synaptic plasticity (GO:0048169)3.48814164
49synaptic transmission, glutamatergic (GO:0035249)3.48617415
50regulation of mononuclear cell migration (GO:0071675)3.47739857
51positive regulation of chemokine biosynthetic process (GO:0045080)3.44858214
52regulation of T-helper 1 cell differentiation (GO:0045625)3.40926870
53ceramide catabolic process (GO:0046514)3.34114451
54negative regulation of dendrite development (GO:2000171)3.32556285
55positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.30463041
56regulation of synaptic plasticity (GO:0048167)3.30277615
57postsynaptic membrane organization (GO:0001941)3.27903199
58regulation of podosome assembly (GO:0071801)3.27607475
59locomotory exploration behavior (GO:0035641)3.26280242
60macrophage activation involved in immune response (GO:0002281)3.24384053
61glutamate receptor signaling pathway (GO:0007215)3.23331149
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.21061175
63cellular response to arsenic-containing substance (GO:0071243)3.19453975
64establishment of synaptic vesicle localization (GO:0097480)3.19428562
65synaptic vesicle transport (GO:0048489)3.19428562
66regulation of cytokine secretion involved in immune response (GO:0002739)3.18672772
67germinal center formation (GO:0002467)3.16119166
68negative regulation of neurotransmitter transport (GO:0051589)3.15887179
69regulation of excitatory postsynaptic membrane potential (GO:0060079)3.14313228
70regulation of chemokine biosynthetic process (GO:0045073)3.13929583
71neuron recognition (GO:0008038)3.13251902
72axonal fasciculation (GO:0007413)3.13007436
73protein localization to endosome (GO:0036010)3.12931121
74inositol phosphate catabolic process (GO:0071545)3.12495948
75regulation of cAMP-dependent protein kinase activity (GO:2000479)3.11775971
76positive regulation of synapse maturation (GO:0090129)3.11495939
77negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.09466105
78positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.07224593
79cerebellar granule cell differentiation (GO:0021707)3.06973665
80negative regulation of interleukin-17 production (GO:0032700)3.02694386
81regulation of early endosome to late endosome transport (GO:2000641)3.01650019
82positive regulation of cellular amide metabolic process (GO:0034250)3.01147514
83response to thyroid hormone (GO:0097066)2.99774624
84sphingosine metabolic process (GO:0006670)2.99709866
85regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.99187706
86regulation of neurotransmitter secretion (GO:0046928)2.96613918
87regulation of membrane protein ectodomain proteolysis (GO:0051043)2.95503790
88response to histamine (GO:0034776)2.95460498
89membrane lipid catabolic process (GO:0046466)2.95419595
90ER overload response (GO:0006983)2.94989337
91exploration behavior (GO:0035640)2.93556822
92positive regulation of type 2 immune response (GO:0002830)2.93179636
93negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.92225961
94regulation of synapse structural plasticity (GO:0051823)2.90925451
95regulation of postsynaptic membrane potential (GO:0060078)2.90174558
96regulation of synaptic transmission, glutamatergic (GO:0051966)2.87068382
97myeloid dendritic cell differentiation (GO:0043011)2.87035533
98neurotransmitter transport (GO:0006836)2.86028737
99proline transport (GO:0015824)2.84765839
100T-helper 1 type immune response (GO:0042088)2.83301799
101sphingolipid catabolic process (GO:0030149)2.82911401
102cellular response to lipopolysaccharide (GO:0071222)2.82328579
103cullin deneddylation (GO:0010388)2.82088202
104calcium ion-dependent exocytosis (GO:0017156)2.81820766
105negative regulation of neurotransmitter secretion (GO:0046929)2.81729033
106granulocyte activation (GO:0036230)2.80906925
107regulation of T-helper 2 cell differentiation (GO:0045628)2.80246290
108learning (GO:0007612)2.80181374
109positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.79223496
110gamma-aminobutyric acid transport (GO:0015812)2.78571380
111positive regulation of membrane potential (GO:0045838)2.77881625
112positive regulation of neurotransmitter secretion (GO:0001956)2.77758848
113positive regulation of interleukin-6 production (GO:0032755)2.77350139
114regulation of neurotransmitter transport (GO:0051588)2.76115233
115establishment of vesicle localization (GO:0051650)2.74975256
116cerebellar Purkinje cell differentiation (GO:0021702)2.73566336
117regulation of heat generation (GO:0031650)2.71620683
118cellular response to molecule of bacterial origin (GO:0071219)2.71236936
119serotonin receptor signaling pathway (GO:0007210)2.68813879
120response to manganese ion (GO:0010042)2.67945808
121negative regulation of nitric oxide biosynthetic process (GO:0045019)2.67711590
122regulation of nitric oxide biosynthetic process (GO:0045428)2.67492023
123neuromuscular process controlling posture (GO:0050884)2.66774823
124negative regulation of lipid storage (GO:0010888)2.65857352
125synaptic transmission (GO:0007268)2.65664137
126positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.65561733
127transmission of nerve impulse (GO:0019226)2.65071566
128adenosine receptor signaling pathway (GO:0001973)2.64709679
129regulation of neurotransmitter levels (GO:0001505)2.64524533
130diol metabolic process (GO:0034311)2.64366081
131regulation of synaptic transmission (GO:0050804)2.63813517
132positive regulation of nitric oxide biosynthetic process (GO:0045429)2.63618375
133regulation of synapse maturation (GO:0090128)2.63450181
134long term synaptic depression (GO:0060292)2.63330532
135regulation of vesicle fusion (GO:0031338)2.62845932
136behavioral response to cocaine (GO:0048148)2.62834209
137iron ion transport (GO:0006826)2.62563349
138neuromuscular process (GO:0050905)2.62284393
139regulation of synaptic transmission, GABAergic (GO:0032228)2.62204631
140mechanosensory behavior (GO:0007638)2.62139029
141interferon-gamma-mediated signaling pathway (GO:0060333)2.61210080
142positive regulation of synaptic transmission (GO:0050806)2.60858378
143cellular response to nerve growth factor stimulus (GO:1990090)2.60822657
144response to nerve growth factor (GO:1990089)2.60822657
145negative regulation of growth of symbiont in host (GO:0044130)2.60398877
146negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.60398877
147modulation of growth of symbiont involved in interaction with host (GO:0044144)2.60398877
148regulation of growth of symbiont in host (GO:0044126)2.60398877
149nerve growth factor signaling pathway (GO:0038180)2.60153169
150positive regulation of leukocyte degranulation (GO:0043302)2.60069149
151positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.59959673
152dendritic cell differentiation (GO:0097028)2.59612540
153regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.57629129
154positive regulation of T-helper cell differentiation (GO:0045624)2.57538859
155regulation of glutamate secretion (GO:0014048)2.56362594
156long-chain fatty acid biosynthetic process (GO:0042759)2.55946757
157detection of calcium ion (GO:0005513)2.55186375
158positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.54332122
159positive regulation of synapse assembly (GO:0051965)2.54189946
160female mating behavior (GO:0060180)2.53943525
161positive regulation of mitochondrial fission (GO:0090141)2.53324654
162positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.53129246
163positive regulation of NF-kappaB import into nucleus (GO:0042346)2.51990705
164G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.51962446
165adult walking behavior (GO:0007628)2.51625663
166regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.51282258
167neuronal ion channel clustering (GO:0045161)2.50798007
168regulation of interferon-alpha production (GO:0032647)2.50648865
169protein deneddylation (GO:0000338)2.49738589
170negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.49575288
171regulation of immunoglobulin secretion (GO:0051023)2.48154330
172negative regulation of protein localization to plasma membrane (GO:1903077)2.47308488
173regulation of type 2 immune response (GO:0002828)2.46223639
174positive regulation of natural killer cell activation (GO:0032816)2.45697617
175positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.43553125
176response to protozoan (GO:0001562)2.43300198
177negative regulation of cytokine production involved in immune response (GO:0002719)2.39522045
178regulation of interleukin-12 production (GO:0032655)2.39369298
179regulation of NF-kappaB import into nucleus (GO:0042345)2.39346563
180regulation of interleukin-8 biosynthetic process (GO:0045414)2.38749530
181defense response to protozoan (GO:0042832)2.36869882
182regulation of interleukin-17 production (GO:0032660)2.36814989
183macrophage activation (GO:0042116)2.36670038
184positive regulation of monocyte chemotaxis (GO:0090026)2.36019383
185positive regulation of gamma-delta T cell activation (GO:0046645)2.35855650
186eosinophil chemotaxis (GO:0048245)2.34622371
187cellular response to biotic stimulus (GO:0071216)2.34176141
188regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.33696944
189myeloid dendritic cell activation (GO:0001773)2.32600917
190myeloid cell activation involved in immune response (GO:0002275)2.32519011
191negative regulation of erythrocyte differentiation (GO:0045647)2.32203460
192monocyte chemotaxis (GO:0002548)2.30768413
193positive regulation of toll-like receptor signaling pathway (GO:0034123)2.30743912
194NIK/NF-kappaB signaling (GO:0038061)2.29893646
195regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.29145907
196negative regulation of myeloid cell apoptotic process (GO:0033033)2.28492563

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.82089646
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.94811598
3* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.86160179
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.79693096
5EZH2_22144423_ChIP-Seq_EOC_Human3.69497642
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.61175588
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.53186685
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.49984136
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.48305327
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.41360913
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.36040996
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.00361043
13TAF15_26573619_Chip-Seq_HEK293_Human2.92398503
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.89009014
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.84834414
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.76474388
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.72217440
18GATA1_22025678_ChIP-Seq_K562_Human2.65659235
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.62704497
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.52648902
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.52038134
22REST_21632747_ChIP-Seq_MESCs_Mouse2.51692143
23* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.48586735
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48309674
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41427897
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.33310115
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.25339979
28JARID2_20064375_ChIP-Seq_MESCs_Mouse2.25181736
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.22950231
30AR_21572438_ChIP-Seq_LNCaP_Human2.21492774
31REST_18959480_ChIP-ChIP_MESCs_Mouse2.17735559
32VDR_24787735_ChIP-Seq_THP-1_Human2.16886458
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.15705872
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.12576275
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.10247139
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.07712551
37GATA2_21666600_ChIP-Seq_HMVEC_Human2.06270708
38P300_19829295_ChIP-Seq_ESCs_Human2.03594433
39SMAD4_21799915_ChIP-Seq_A2780_Human2.03217046
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02607076
41TFEB_21752829_ChIP-Seq_HELA_Human2.02214214
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99575347
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98159003
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.97323881
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96618049
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95868264
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95868264
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.95218469
49SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.92187001
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91868779
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.91629999
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.91618158
53IGF1R_20145208_ChIP-Seq_DFB_Human1.89975898
54STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.88333599
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86922288
56RARB_27405468_Chip-Seq_BRAIN_Mouse1.85871675
57SPI1_23127762_ChIP-Seq_K562_Human1.81465992
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.79670440
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.78075327
60FUS_26573619_Chip-Seq_HEK293_Human1.72482582
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70220922
62* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69130506
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.69102500
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.68899818
65RNF2_27304074_Chip-Seq_NSC_Mouse1.66122676
66SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.64979394
67* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64925335
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.59036557
69PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57463598
70AR_25329375_ChIP-Seq_VCAP_Human1.54719774
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.53787429
72SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52781033
73PU_27001747_Chip-Seq_BMDM_Mouse1.52554732
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52165518
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51812792
76SPI1_23547873_ChIP-Seq_NB4_Human1.50870734
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.49923584
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45544477
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44746823
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44735388
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.44266806
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43866417
83SCL_19346495_ChIP-Seq_HPC-7_Human1.43750113
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43202485
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.41051465
86* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.40826040
87VDR_22108803_ChIP-Seq_LS180_Human1.40587733
88STAT3_23295773_ChIP-Seq_U87_Human1.38805394
89* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.37828937
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37222911
91CLOCK_20551151_ChIP-Seq_293T_Human1.35325427
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.34969741
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34394328
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34394328
95* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33503239
96ER_23166858_ChIP-Seq_MCF-7_Human1.33411323
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33182317
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31997010
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31918865
100SOX2_20726797_ChIP-Seq_SW620_Human1.31626609
101SOX2_21211035_ChIP-Seq_LN229_Gbm1.29797684
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29587885
103SMAD_19615063_ChIP-ChIP_OVARY_Human1.29516233
104* TCF4_23295773_ChIP-Seq_U87_Human1.29119870
105NANOG_18555785_Chip-Seq_ESCs_Mouse1.27797391
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27636699
107PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26802647
108GATA1_19941826_ChIP-Seq_K562_Human1.26133688
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25784146
110LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25291358
111JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24761714
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.23969720
113TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23760405
114NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23694032
115ESR1_21235772_ChIP-Seq_MCF-7_Human1.23446708
116JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23167500
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20617910
118NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20617910
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20354520
120E2F1_18555785_Chip-Seq_ESCs_Mouse1.19874071
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18619278
122EWS_26573619_Chip-Seq_HEK293_Human1.18585957
123JUN_21703547_ChIP-Seq_K562_Human1.18249371
124SOX2_18555785_Chip-Seq_ESCs_Mouse1.17129871
125ARNT_22903824_ChIP-Seq_MCF-7_Human1.16704814
126RUNX2_22187159_ChIP-Seq_PCA_Human1.16473763
127FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16107090
128* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16043950
129* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15685697
130STAT3_18555785_Chip-Seq_ESCs_Mouse1.15319927
131CMYC_18555785_Chip-Seq_ESCs_Mouse1.15272336
132ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14792383
133P53_22387025_ChIP-Seq_ESCs_Mouse1.13395468
134RXR_22108803_ChIP-Seq_LS180_Human1.13010848
135CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12671533
136RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10576003
137RUNX1_22412390_ChIP-Seq_EML_Mouse1.10454311
138MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09368727
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08924376
140* GATA2_19941826_ChIP-Seq_K562_Human1.08884164
141ESR2_21235772_ChIP-Seq_MCF-7_Human1.08839611
142MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08822948
143* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08087359
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07818728
145CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07803300
146P300_18555785_Chip-Seq_ESCs_Mouse1.07258182
147CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07213906
148WT1_19549856_ChIP-ChIP_CCG9911_Human1.06070673
149SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05720325
150SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05066780
151VDR_24763502_ChIP-Seq_THP-1_Human1.04660294
152SOX9_26525672_Chip-Seq_HEART_Mouse1.04531004
153RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03058308
154ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02919254
155MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00988991
156FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00862680
157RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00323670
158CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99186474
159DROSHA_22980978_ChIP-Seq_HELA_Human0.99065767
160ERG_21242973_ChIP-ChIP_JURKAT_Human0.97770236
161VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97533483
162TP53_18474530_ChIP-ChIP_U2OS_Human0.97238180
163AHR_22903824_ChIP-Seq_MCF-7_Human0.97020416
164MYB_26560356_Chip-Seq_TH2_Human0.96986426
165* CJUN_26792858_Chip-Seq_BT549_Human0.96853412
166* AR_19668381_ChIP-Seq_PC3_Human0.95968197
167SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95860547
168PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95335672
169NMYC_18555785_Chip-Seq_ESCs_Mouse0.94826299
170ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94108259
171EGR1_19032775_ChIP-ChIP_M12_Human0.93967758
172BRD4_25478319_ChIP-Seq_HGPS_Human0.93411173
173GATA3_26560356_Chip-Seq_TH2_Human0.91605032
174GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89489954
175* TP63_23658742_ChIP-Seq_EP156T_Human0.87041986
176RUNX_20019798_ChIP-Seq_JUKART_Human0.84849518
177* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84799942
178GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83895849
179PU1_27457419_Chip-Seq_LIVER_Mouse0.83407634
180GATA1_19941827_ChIP-Seq_MEL_Mouse0.81933312
181PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80767893
182PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.80439355
183FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.79955459
184* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79337220
185ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.77960876
186GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.77930223
187EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.77765285
188GATA2_22383799_ChIP-Seq_G1ME_Mouse0.77652280

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.87332586
2MP0003303_peritoneal_inflammation4.80020083
3MP0003880_abnormal_central_pattern4.41179825
4MP0003635_abnormal_synaptic_transmissio3.54226500
5MP0009046_muscle_twitch3.40928922
6MP0006082_CNS_inflammation3.36118076
7MP0002064_seizures3.22014250
8MP0004270_analgesia3.18188841
9MP0002063_abnormal_learning/memory/cond3.17655471
10MP0009745_abnormal_behavioral_response3.17482775
11MP0002148_abnormal_hypersensitivity_rea2.98771144
12MP0001968_abnormal_touch/_nociception2.84641530
13MP0002572_abnormal_emotion/affect_behav2.84480950
14MP0004510_myositis2.80298920
15MP0002735_abnormal_chemical_nociception2.71938478
16MP0002877_abnormal_melanocyte_morpholog2.71118324
17MP0003300_gastrointestinal_ulcer2.61418110
18MP0002736_abnormal_nociception_after2.60911627
19MP0003724_increased_susceptibility_to2.60035049
20MP0002734_abnormal_mechanical_nocicepti2.54494344
21MP0009785_altered_susceptibility_to2.49017988
22MP0005646_abnormal_pituitary_gland2.48414860
23MP0002272_abnormal_nervous_system2.47720973
24MP0005171_absent_coat_pigmentation2.47143594
25MP0009840_abnormal_foam_cell2.42460801
26MP0000343_altered_response_to2.36265736
27MP0003436_decreased_susceptibility_to2.27880858
28MP0001486_abnormal_startle_reflex2.24154262
29MP0001501_abnormal_sleep_pattern2.22932272
30MP0003656_abnormal_erythrocyte_physiolo2.20827112
31MP0005645_abnormal_hypothalamus_physiol2.19796009
32MP0002733_abnormal_thermal_nociception2.19068177
33MP0005423_abnormal_somatic_nervous2.15184148
34MP0001835_abnormal_antigen_presentation2.14965317
35MP0001970_abnormal_pain_threshold2.14812616
36MP0005167_abnormal_blood-brain_barrier2.09900840
37MP0002139_abnormal_hepatobiliary_system2.07060542
38MP0005000_abnormal_immune_tolerance2.03260555
39MP0003183_abnormal_peptide_metabolism2.01876644
40MP0010234_abnormal_vibrissa_follicle2.01524554
41MP0002419_abnormal_innate_immunity1.99352008
42MP0001440_abnormal_grooming_behavior1.97593470
43MP0002067_abnormal_sensory_capabilities1.96520752
44MP0001984_abnormal_olfaction1.96053405
45MP0005464_abnormal_platelet_physiology1.96017128
46MP0006054_spinal_hemorrhage1.94321309
47MP0003122_maternal_imprinting1.84989594
48MP0008004_abnormal_stomach_pH1.82590866
49MP0009780_abnormal_chondrocyte_physiolo1.82395048
50MP0003453_abnormal_keratinocyte_physiol1.81566174
51MP0001790_abnormal_immune_system1.79262367
52MP0005387_immune_system_phenotype1.79262367
53MP0003191_abnormal_cellular_cholesterol1.79124796
54MP0003787_abnormal_imprinting1.78842623
55MP0003806_abnormal_nucleotide_metabolis1.78379384
56MP0009764_decreased_sensitivity_to1.77091603
57MP0003172_abnormal_lysosome_physiology1.75599166
58MP0004947_skin_inflammation1.74962393
59MP0000778_abnormal_nervous_system1.74457894
60MP0005025_abnormal_response_to1.67959735
61MP0010386_abnormal_urinary_bladder1.67556944
62MP0008569_lethality_at_weaning1.62302594
63MP0004811_abnormal_neuron_physiology1.61581595
64MP0005386_behavior/neurological_phenoty1.60951152
65MP0004924_abnormal_behavior1.60951152
66MP0005451_abnormal_body_composition1.60690947
67MP0005671_abnormal_response_to1.57098118
68MP0005166_decreased_susceptibility_to1.55858279
69MP0006276_abnormal_autonomic_nervous1.55330496
70MP0003879_abnormal_hair_cell1.55072891
71MP0001853_heart_inflammation1.53665075
72MP0002184_abnormal_innervation1.48839530
73MP0002452_abnormal_antigen_presenting1.47188050
74MP0003448_altered_tumor_morphology1.46852436
75MP0002723_abnormal_immune_serum1.45785933
76MP0001905_abnormal_dopamine_level1.45226760
77MP0001529_abnormal_vocalization1.44314063
78MP0002557_abnormal_social/conspecific_i1.43404478
79MP0000955_abnormal_spinal_cord1.42377135
80MP0002909_abnormal_adrenal_gland1.41680062
81MP0004142_abnormal_muscle_tone1.40186834
82MP0001845_abnormal_inflammatory_respons1.39290055
83MP0001533_abnormal_skeleton_physiology1.38909162
84MP0002822_catalepsy1.38595987
85MP0002066_abnormal_motor_capabilities/c1.37948397
86MP0001188_hyperpigmentation1.35580673
87MP0001502_abnormal_circadian_rhythm1.31840307
88MP0002998_abnormal_bone_remodeling1.31639335
89MP0002876_abnormal_thyroid_physiology1.29868234
90MP0003633_abnormal_nervous_system1.28400174
91MP0008469_abnormal_protein_level1.25097662
92MP0005397_hematopoietic_system_phenotyp1.23334843
93MP0001545_abnormal_hematopoietic_system1.23334843
94MP0005058_abnormal_lysosome_morphology1.22466842
95MP0002882_abnormal_neuron_morphology1.22029588
96MP0001986_abnormal_taste_sensitivity1.21531453
97MP0010155_abnormal_intestine_physiology1.21117360
98MP0000685_abnormal_immune_system1.18037075
99MP0003329_amyloid_beta_deposits1.17132742
100MP0001800_abnormal_humoral_immune1.16771356
101MP0005165_increased_susceptibility_to1.16564486
102MP0002254_reproductive_system_inflammat1.15449586
103MP0000858_altered_metastatic_potential1.15131337
104MP0000013_abnormal_adipose_tissue1.15008009
105MP0001819_abnormal_immune_cell1.13614308
106MP0002420_abnormal_adaptive_immunity1.13462266
107MP0003631_nervous_system_phenotype1.11969240
108MP0008877_abnormal_DNA_methylation1.09354921
109MP0002090_abnormal_vision1.06788973
110MP0010352_gastrointestinal_tract_polyps1.05887861
111MP0005164_abnormal_response_to1.04852504
112MP0008874_decreased_physiological_sensi1.04049332
113MP0001177_atelectasis1.03770014
114MP0003634_abnormal_glial_cell1.02993050
115MP0003828_pulmonary_edema1.02866917
116MP0001963_abnormal_hearing_physiology1.01056094
117MP0002405_respiratory_system_inflammati1.00811386
118MP0000516_abnormal_urinary_system0.99401714
119MP0005367_renal/urinary_system_phenotyp0.99401714
120MP0003091_abnormal_cell_migration0.97902225
121MP0001851_eye_inflammation0.97805262
122MP0003221_abnormal_cardiomyocyte_apopto0.97698048
123MP0008260_abnormal_autophagy0.93639606
124MP0003690_abnormal_glial_cell0.92051818
125MP0000569_abnormal_digit_pigmentation0.89462988
126MP0004233_abnormal_muscle_weight0.88330447
127MP0000681_abnormal_thyroid_gland0.87736246
128MP0005535_abnormal_body_temperature0.87454408
129MP0001542_abnormal_bone_strength0.87045372
130MP0002229_neurodegeneration0.87003797
131MP0004484_altered_response_of0.86058779
132MP0000920_abnormal_myelination0.86008829
133MP0009763_increased_sensitivity_to0.85078449
134MP0004742_abnormal_vestibular_system0.84611990
135MP0001191_abnormal_skin_condition0.84190811
136MP0002069_abnormal_eating/drinking_beha0.84019643
137MP0003632_abnormal_nervous_system0.83325464
138MP0009333_abnormal_splenocyte_physiolog0.82989032
139MP0004858_abnormal_nervous_system0.80996760
140MP0002152_abnormal_brain_morphology0.79654261
141MP0004885_abnormal_endolymph0.79549497
142MP0000015_abnormal_ear_pigmentation0.78955553
143MP0000465_gastrointestinal_hemorrhage0.78051005
144MP0000372_irregular_coat_pigmentation0.78021186
145MP0002796_impaired_skin_barrier0.77766406
146MP0000371_diluted_coat_color0.77670474
147MP0000631_abnormal_neuroendocrine_gland0.76276583
148MP0002837_dystrophic_cardiac_calcinosis0.75169216
149MP0001216_abnormal_epidermal_layer0.74305367
150MP0000716_abnormal_immune_system0.73190378
151MP0009278_abnormal_bone_marrow0.71924364
152MP0003075_altered_response_to0.71211462
153MP0003186_abnormal_redox_activity0.70473073
154MP0010678_abnormal_skin_adnexa0.70159358
155MP0000604_amyloidosis0.69548759
156MP0004147_increased_porphyrin_level0.68880598
157MP0004043_abnormal_pH_regulation0.68225963
158MP0008995_early_reproductive_senescence0.66958192
159MP0003950_abnormal_plasma_membrane0.66948047
160MP0002653_abnormal_ependyma_morphology0.66521728
161MP0004145_abnormal_muscle_electrophysio0.65942152
162MP0009765_abnormal_xenobiotic_induced0.64471267
163MP0003121_genomic_imprinting0.63678200
164MP0004883_abnormal_blood_vessel0.62863031
165MP0005388_respiratory_system_phenotype0.62769032
166MP0002133_abnormal_respiratory_system0.62769032
167MP0004808_abnormal_hematopoietic_stem0.62678188
168MP0005310_abnormal_salivary_gland0.61836002
169MP0003279_aneurysm0.59881223
170MP0000249_abnormal_blood_vessel0.59726387
171MP0001943_abnormal_respiration0.59284497
172MP0002398_abnormal_bone_marrow0.58248840
173MP0002332_abnormal_exercise_endurance0.53984140
174MP0000026_abnormal_inner_ear0.53835716
175MP0002009_preneoplasia0.53574027
176MP0000751_myopathy0.53300794
177MP0009697_abnormal_copulation0.52962912
178MP0005499_abnormal_olfactory_system0.51827877
179MP0005394_taste/olfaction_phenotype0.51827877

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.91178215
2Atonic seizures (HP:0010819)5.77169378
3Epileptic encephalopathy (HP:0200134)5.45514931
4Febrile seizures (HP:0002373)4.96066711
5Loss of speech (HP:0002371)4.32546255
6Vacuolated lymphocytes (HP:0001922)4.24537840
7Disinhibition (HP:0000734)4.22032939
8Neurofibrillary tangles (HP:0002185)4.15079777
9Hyperventilation (HP:0002883)4.07824629
10Pheochromocytoma (HP:0002666)4.06710131
11Focal seizures (HP:0007359)4.05642856
12Absence seizures (HP:0002121)3.97902923
13Neuroendocrine neoplasm (HP:0100634)3.87418126
14Dialeptic seizures (HP:0011146)3.76844153
15Visual hallucinations (HP:0002367)3.72202324
16Apathy (HP:0000741)3.63932225
17Abnormality of macrophages (HP:0004311)3.60249086
18Diminished motivation (HP:0000745)3.57198452
19Myokymia (HP:0002411)3.55285768
20Abnormal hair whorl (HP:0010721)3.36017777
21Fetal akinesia sequence (HP:0001989)3.33853099
22Generalized tonic-clonic seizures (HP:0002069)3.31486317
23Cerebral inclusion bodies (HP:0100314)3.27738965
24Gait imbalance (HP:0002141)3.18007028
25Medial flaring of the eyebrow (HP:0010747)3.17275335
26Abnormal eating behavior (HP:0100738)3.13850763
27Failure to thrive in infancy (HP:0001531)3.10070951
28Abnormality of mucopolysaccharide metabolism (HP:0011020)3.05576448
29Abnormality of polysaccharide metabolism (HP:0011012)3.05576448
30Broad-based gait (HP:0002136)3.04418564
31Nuclear cataract (HP:0100018)3.01926582
32Neuronal loss in central nervous system (HP:0002529)3.00644718
33Congenital primary aphakia (HP:0007707)3.00322860
34Tetraparesis (HP:0002273)2.93894122
35Recurrent bacterial skin infections (HP:0005406)2.92730733
36Systemic lupus erythematosus (HP:0002725)2.87185882
37Nephrogenic diabetes insipidus (HP:0009806)2.85155359
38Axonal loss (HP:0003447)2.80984808
39Progressive cerebellar ataxia (HP:0002073)2.75763365
40Polyphagia (HP:0002591)2.66899020
41Stomatitis (HP:0010280)2.58672497
42Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.58671830
43Poor coordination (HP:0002370)2.56281547
44Progressive neurologic deterioration (HP:0002344)2.55807159
45Recurrent abscess formation (HP:0002722)2.55015654
46Poor suck (HP:0002033)2.54954008
47Neoplasm of the peripheral nervous system (HP:0100007)2.50392994
48Clumsiness (HP:0002312)2.49619810
49Akinesia (HP:0002304)2.49134509
50Autoimmune thrombocytopenia (HP:0001973)2.47965955
51Eczematoid dermatitis (HP:0000976)2.45598635
52Optic neuritis (HP:0100653)2.40131004
53Retrobulbar optic neuritis (HP:0100654)2.40131004
54Gaze-evoked nystagmus (HP:0000640)2.39175678
55Protruding tongue (HP:0010808)2.38068699
56Epileptiform EEG discharges (HP:0011182)2.37997915
57Interstitial pulmonary disease (HP:0006530)2.35538006
58Dysautonomia (HP:0002459)2.34571451
59Orchitis (HP:0100796)2.33358253
60Poor eye contact (HP:0000817)2.33308773
61Genital tract atresia (HP:0001827)2.30861253
62Personality changes (HP:0000751)2.29900065
63Vaginal atresia (HP:0000148)2.28780957
64Abnormality of the vasculature of the conjunctiva (HP:0008054)2.25710829
65Amblyopia (HP:0000646)2.24861290
66Increased CSF protein (HP:0002922)2.22777090
67Increased cerebral lipofuscin (HP:0011813)2.22452385
68Sleep apnea (HP:0010535)2.21921021
69Hematochezia (HP:0002573)2.20506232
70Agnosia (HP:0010524)2.20138532
71Increased neuronal autofluorescent lipopigment (HP:0002074)2.19062678
72Drooling (HP:0002307)2.19024203
73Excessive salivation (HP:0003781)2.19024203
74Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.17625308
75Delusions (HP:0000746)2.17029426
76Petechiae (HP:0000967)2.16407008
77Abnormality of binocular vision (HP:0011514)2.15941703
78Diplopia (HP:0000651)2.15941703
79Termporal pattern (HP:0011008)2.14894059
80Insidious onset (HP:0003587)2.14894059
81Acute necrotizing encephalopathy (HP:0006965)2.14019235
82Dysdiadochokinesis (HP:0002075)2.13593049
83Hepatosplenomegaly (HP:0001433)2.12870275
84Abnormality of the labia minora (HP:0012880)2.12749577
85Specific learning disability (HP:0001328)2.12393476
86Amyloidosis (HP:0011034)2.11785736
87Prolonged neonatal jaundice (HP:0006579)2.11438632
88Myocardial infarction (HP:0001658)2.11258365
89EEG with generalized epileptiform discharges (HP:0011198)2.10512974
90Dementia (HP:0000726)2.09128795
91Diminished movement (HP:0002374)2.07393500
92Abnormal mitochondria in muscle tissue (HP:0008316)2.06713721
93Papilledema (HP:0001085)2.06389490
94Action tremor (HP:0002345)2.05580361
95Supranuclear gaze palsy (HP:0000605)2.04208328
96Purpura (HP:0000979)2.03532903
97Resting tremor (HP:0002322)2.02588458
98Impaired social interactions (HP:0000735)2.02422434
99Abnormal social behavior (HP:0012433)2.02422434
100Esotropia (HP:0000565)2.01699677
101Progressive macrocephaly (HP:0004481)2.01095977
102Anxiety (HP:0000739)2.00919526
103Truncal ataxia (HP:0002078)2.00117134
104Dysostosis multiplex (HP:0000943)1.99884435
105Myositis (HP:0100614)1.99539148
106Global brain atrophy (HP:0002283)1.99093919
107Asymmetric septal hypertrophy (HP:0001670)1.98615486
108Generalized myoclonic seizures (HP:0002123)1.98146543
109Mediastinal lymphadenopathy (HP:0100721)1.97840742
110Hypsarrhythmia (HP:0002521)1.95112517
111Papillary thyroid carcinoma (HP:0002895)1.95000937
112Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.94793646
113Degeneration of the lateral corticospinal tracts (HP:0002314)1.94793646
114Upper motor neuron abnormality (HP:0002127)1.94766843
115Memory impairment (HP:0002354)1.92875010
116Sensorimotor neuropathy (HP:0007141)1.92476323
117Progressive inability to walk (HP:0002505)1.90664023
118Ankle clonus (HP:0011448)1.90105863
119Inability to walk (HP:0002540)1.90032677
120Increased serum ferritin (HP:0003281)1.88292622
121Blue irides (HP:0000635)1.88000687
122Hypothermia (HP:0002045)1.87717895
123Urinary incontinence (HP:0000020)1.87020351
124Basal ganglia calcification (HP:0002135)1.86950136
125Tongue fasciculations (HP:0001308)1.86943415
126Depression (HP:0000716)1.86932542
127Gangrene (HP:0100758)1.86578413
128Polyneuropathy (HP:0001271)1.86207881
129Oligomenorrhea (HP:0000876)1.84649658
130Cerebral hemorrhage (HP:0001342)1.84643864
131Abnormality of aromatic amino acid family metabolism (HP:0004338)1.84388338
132Dysmetria (HP:0001310)1.83623366
133Thick nail (HP:0001805)1.83178701
134Narrow nasal bridge (HP:0000446)1.82090191
135Autoimmune hemolytic anemia (HP:0001890)1.81641163
136Pulmonary infiltrates (HP:0002113)1.80961724
137Absent speech (HP:0001344)1.80732465
138Postural tremor (HP:0002174)1.79484271
139Urinary glycosaminoglycan excretion (HP:0003541)1.79366053
140Mucopolysacchariduria (HP:0008155)1.79366053
141Mutism (HP:0002300)1.78582157
142Abnormality of the periventricular white matter (HP:0002518)1.78186640
143Hypokinesia (HP:0002375)1.77775588
144Abnormality of glycolipid metabolism (HP:0010969)1.74852303
145Abnormality of liposaccharide metabolism (HP:0010968)1.74852303
146Abnormality of glycosphingolipid metabolism (HP:0004343)1.74852303
147Bradykinesia (HP:0002067)1.73924609
148Thickened helices (HP:0000391)1.73690483
149Vertebral compression fractures (HP:0002953)1.73636763
150Abnormality of the basal ganglia (HP:0002134)1.73191821
151Inappropriate behavior (HP:0000719)1.72691327
152Hip dysplasia (HP:0001385)1.70501319
153Absent eyebrow (HP:0002223)1.68921312
154Joint swelling (HP:0001386)1.68693360
155Abnormal autonomic nervous system physiology (HP:0012332)1.68392855
156Episodic fever (HP:0001954)1.68070533
157Mitochondrial inheritance (HP:0001427)1.67894557
158Slow saccadic eye movements (HP:0000514)1.67478913
159Keratoconjunctivitis sicca (HP:0001097)1.65270288
160Glomerulonephritis (HP:0000099)1.65077641
161Abnormality of the corticospinal tract (HP:0002492)1.64110767
162Autoamputation (HP:0001218)1.63546280
163Tetraplegia (HP:0002445)1.63178091
164Aplasia/Hypoplasia of the lens (HP:0008063)1.63076554
165Postural instability (HP:0002172)1.62364537
166Abnormality of salivation (HP:0100755)1.61649739
167Increased serum pyruvate (HP:0003542)1.61455158
168Abnormality of glycolysis (HP:0004366)1.61455158
169Submucous cleft hard palate (HP:0000176)1.61264480
170Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.61254075
171Abnormality of glycosaminoglycan metabolism (HP:0004371)1.61045553
172Cardiomegaly (HP:0001640)1.61045472
173Parakeratosis (HP:0001036)1.58778957
174Spastic gait (HP:0002064)1.58199789
175Conjunctival hamartoma (HP:0100780)1.57957732
176Nausea (HP:0002018)1.56485893
177Recurrent gram-negative bacterial infections (HP:0005420)1.54956653
178Rapidly progressive (HP:0003678)1.54852003
179Bone pain (HP:0002653)1.54321008
180Conjunctival telangiectasia (HP:0000524)1.53287238
181Cholecystitis (HP:0001082)1.52449746
182Abnormal gallbladder physiology (HP:0012438)1.52449746
183Albinism (HP:0001022)1.52156282

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.29812389
2IRAK35.10171865
3AKT33.10931808
4NTRK32.97336318
5MAP2K72.92189667
6MAP3K122.89045915
7PRPF4B2.75375830
8PLK22.70325010
9EPHA42.65860681
10MAP3K42.46818363
11RIPK42.30242566
12DAPK12.28126254
13GRK72.23914938
14SIK32.23499877
15NME22.10059648
16TBK12.02742271
17MINK11.89394067
18CCNB11.83995174
19CDK191.83270759
20MAP3K131.73084964
21DAPK21.72322823
22SGK21.70896081
23ERBB31.67627462
24RIPK11.62733652
25MOS1.55632782
26BMPR21.55294989
27LATS21.49407441
28IKBKB1.45399073
29SCYL21.44819633
30SGK4941.44041379
31SGK2231.44041379
32TGFBR21.42933049
33TESK11.36424950
34TYK21.36276499
35PINK11.34406601
36CAMKK21.34386628
37EIF2AK31.33687585
38MAPK131.32140400
39MAP3K51.31448778
40MAP2K41.31309595
41MAP3K11.30919842
42OXSR11.29127909
43MAP3K61.24238093
44MAP3K91.21534542
45BLK1.20606581
46JAK11.19727864
47UHMK11.16729285
48SGK31.16647140
49TSSK61.15855718
50EPHA31.14257405
51MARK11.13726557
52PDK31.12563679
53PDK41.12563679
54ABL21.12282883
55FRK1.11684220
56TRIM281.11048188
57IKBKE1.10338788
58YES11.10168432
59PRKCG1.09308764
60BCR1.05643034
61GRK51.04784236
62CDK51.00764270
63IRAK20.98031295
64BMPR1B0.97258612
65NEK60.97229594
66MST40.97004341
67CAMK2A0.96126324
68ARAF0.94475957
69JAK20.93866302
70CAMK2B0.92868721
71MAP3K20.90945425
72TNIK0.90758187
73PRKCE0.90222975
74PDK20.87990330
75CSK0.87487638
76MAPK150.87351181
77MKNK20.87240968
78TAOK10.86561611
79MAP2K30.86202966
80PAK60.86048540
81PRKD30.85693547
82CDK60.85601573
83DDR20.84740893
84KSR10.82926040
85FGR0.82486612
86NME10.82389762
87JAK30.81154266
88BRAF0.80865020
89CDK80.80212586
90TAOK30.79556212
91CAMKK10.75434331
92BRSK10.71708494
93NTRK20.71523532
94PDGFRA0.71253399
95TAOK20.68198685
96ADRBK20.66802884
97NTRK10.65922871
98CDK180.64917387
99ACVR1B0.63215497
100ZAP700.63109516
101SGK10.62285173
102CDK140.59621596
103SYK0.58504925
104CHUK0.57755923
105MATK0.57277096
106IRAK10.56845390
107CLK10.56833866
108PLK30.55906828
109MARK30.55304191
110FES0.55265483
111STK240.54349165
112PKN10.52911023
113MAPK40.52315335
114MAP3K110.51685670
115CAMK2D0.51478975
116TXK0.50866616
117CDK150.50197419
118NEK90.49953229
119RPS6KA20.49003383
120PHKG20.48465134
121PHKG10.48465134
122IRAK40.47457328
123NEK10.46817767
124DAPK30.46756750
125PIM20.46456638
126ABL10.46322006
127PAK40.44989413
128RPS6KL10.44855680
129RPS6KC10.44855680
130LYN0.44517491
131CAMK2G0.44455226
132EIF2AK10.44440495
133TRPM70.44096236
134MAP3K30.43758864
135MAP2K60.43232698
136RPS6KB10.43220818
137ALK0.42394397
138LIMK10.39949053
139FER0.39503183
140PRKCH0.38505941
141DYRK1A0.38418997
142FGFR30.38315100
143RAF10.37609255
144RPS6KA60.37334100
145TYRO30.35784201
146PDPK10.35279988
147MKNK10.35085171
148CDK11A0.34997251
149MAP2K10.34744912
150HCK0.34482964
151PDK10.34429610
152KSR20.34003732
153GSK3A0.33604937
154MAP3K140.33500685
155TEC0.33061256

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.25167923
2Collecting duct acid secretion_Homo sapiens_hsa049663.82613952
3Nicotine addiction_Homo sapiens_hsa050333.55722465
4Other glycan degradation_Homo sapiens_hsa005112.85261870
5Vibrio cholerae infection_Homo sapiens_hsa051102.69965717
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.61619580
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.52063028
8GABAergic synapse_Homo sapiens_hsa047272.40909438
9Long-term potentiation_Homo sapiens_hsa047202.36067586
10Circadian entrainment_Homo sapiens_hsa047132.28758036
11Osteoclast differentiation_Homo sapiens_hsa043802.28605532
12Amphetamine addiction_Homo sapiens_hsa050312.21253585
13Olfactory transduction_Homo sapiens_hsa047402.21176069
14Morphine addiction_Homo sapiens_hsa050322.20037547
15NOD-like receptor signaling pathway_Homo sapiens_hsa046212.08639043
16Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051202.02723457
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.96259722
18TNF signaling pathway_Homo sapiens_hsa046681.95795899
19Dopaminergic synapse_Homo sapiens_hsa047281.94940235
20Rheumatoid arthritis_Homo sapiens_hsa053231.92326894
21Glutamatergic synapse_Homo sapiens_hsa047241.84530816
22Leishmaniasis_Homo sapiens_hsa051401.83361294
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.77558964
24Phagosome_Homo sapiens_hsa041451.74645779
25Serotonergic synapse_Homo sapiens_hsa047261.74638146
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73648470
27Malaria_Homo sapiens_hsa051441.72923623
28Taste transduction_Homo sapiens_hsa047421.71417310
29Long-term depression_Homo sapiens_hsa047301.66397500
30Insulin secretion_Homo sapiens_hsa049111.64147598
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.58840541
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56775220
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54583879
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.52468693
35Staphylococcus aureus infection_Homo sapiens_hsa051501.48807101
36Oxidative phosphorylation_Homo sapiens_hsa001901.47016942
37Salivary secretion_Homo sapiens_hsa049701.45280916
38Allograft rejection_Homo sapiens_hsa053301.44071548
39Type I diabetes mellitus_Homo sapiens_hsa049401.43661775
40Asthma_Homo sapiens_hsa053101.42798400
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41971967
42Renin secretion_Homo sapiens_hsa049241.35334056
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35274013
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34832016
45Toxoplasmosis_Homo sapiens_hsa051451.29245700
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27708270
47Influenza A_Homo sapiens_hsa051641.27535950
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27023163
49Graft-versus-host disease_Homo sapiens_hsa053321.25730235
50Cholinergic synapse_Homo sapiens_hsa047251.25329178
51Sphingolipid metabolism_Homo sapiens_hsa006001.22651365
52Gastric acid secretion_Homo sapiens_hsa049711.21539387
53Calcium signaling pathway_Homo sapiens_hsa040201.21029102
54Cocaine addiction_Homo sapiens_hsa050301.13947670
55Lysosome_Homo sapiens_hsa041421.12792626
56Chemokine signaling pathway_Homo sapiens_hsa040621.12752632
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10164883
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.07266410
59Oxytocin signaling pathway_Homo sapiens_hsa049211.06786328
60Gap junction_Homo sapiens_hsa045401.06245929
61Hepatitis C_Homo sapiens_hsa051601.04580810
62Amoebiasis_Homo sapiens_hsa051461.01649582
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97632397
64Measles_Homo sapiens_hsa051620.96684154
65B cell receptor signaling pathway_Homo sapiens_hsa046620.95366669
66Hepatitis B_Homo sapiens_hsa051610.94486872
67Autoimmune thyroid disease_Homo sapiens_hsa053200.92499477
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92194833
69Regulation of autophagy_Homo sapiens_hsa041400.92106421
70Circadian rhythm_Homo sapiens_hsa047100.91981284
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.91755249
72Alzheimers disease_Homo sapiens_hsa050100.91722809
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89640710
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.88280622
75ErbB signaling pathway_Homo sapiens_hsa040120.88090861
76Oocyte meiosis_Homo sapiens_hsa041140.87885059
77GnRH signaling pathway_Homo sapiens_hsa049120.87371084
78Bladder cancer_Homo sapiens_hsa052190.87204099
79Prolactin signaling pathway_Homo sapiens_hsa049170.87114581
80VEGF signaling pathway_Homo sapiens_hsa043700.87034044
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87024776
82Hematopoietic cell lineage_Homo sapiens_hsa046400.84639140
83Dorso-ventral axis formation_Homo sapiens_hsa043200.83767257
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81337547
85Axon guidance_Homo sapiens_hsa043600.80705878
86Protein export_Homo sapiens_hsa030600.78047099
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77815567
88Sulfur metabolism_Homo sapiens_hsa009200.77575465
89cAMP signaling pathway_Homo sapiens_hsa040240.77368025
90Renal cell carcinoma_Homo sapiens_hsa052110.77125230
91Parkinsons disease_Homo sapiens_hsa050120.76679361
92Acute myeloid leukemia_Homo sapiens_hsa052210.75260558
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73267602
94Herpes simplex infection_Homo sapiens_hsa051680.71460474
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71387695
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69050286
97Estrogen signaling pathway_Homo sapiens_hsa049150.65102472
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64606982
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63622926
100Cardiac muscle contraction_Homo sapiens_hsa042600.63590752
101MAPK signaling pathway_Homo sapiens_hsa040100.62970600
102Tuberculosis_Homo sapiens_hsa051520.62810816
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61950592
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.61834005
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61547029
106Type II diabetes mellitus_Homo sapiens_hsa049300.61022040
107Apoptosis_Homo sapiens_hsa042100.60252419
108Huntingtons disease_Homo sapiens_hsa050160.59968504
109Antigen processing and presentation_Homo sapiens_hsa046120.58757311
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58637991
111Glioma_Homo sapiens_hsa052140.57728419
112Platelet activation_Homo sapiens_hsa046110.57616285
113Pancreatic secretion_Homo sapiens_hsa049720.56909560
114T cell receptor signaling pathway_Homo sapiens_hsa046600.56834535
115Legionellosis_Homo sapiens_hsa051340.56454084
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56314227
117N-Glycan biosynthesis_Homo sapiens_hsa005100.55142563
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.54979765
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.54170620
120HIF-1 signaling pathway_Homo sapiens_hsa040660.53269789
121Pancreatic cancer_Homo sapiens_hsa052120.51868937
122Fatty acid biosynthesis_Homo sapiens_hsa000610.50096065
123Melanogenesis_Homo sapiens_hsa049160.49639642
124Viral myocarditis_Homo sapiens_hsa054160.48594591
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47868195
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47860161
127Chronic myeloid leukemia_Homo sapiens_hsa052200.46532762
128Salmonella infection_Homo sapiens_hsa051320.44748657
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44477663
130Ras signaling pathway_Homo sapiens_hsa040140.43291525
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.39499678
132Epstein-Barr virus infection_Homo sapiens_hsa051690.39374039
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38216929
134African trypanosomiasis_Homo sapiens_hsa051430.37340492
135Fatty acid elongation_Homo sapiens_hsa000620.36044094
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35653577
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35624775
138Thyroid hormone synthesis_Homo sapiens_hsa049180.35232461
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.34696095
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.34689459
141Endocytosis_Homo sapiens_hsa041440.34058497
142Inositol phosphate metabolism_Homo sapiens_hsa005620.31865225
143Phototransduction_Homo sapiens_hsa047440.31076241
144Melanoma_Homo sapiens_hsa052180.30894914
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30259220
1462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30154964
147Dilated cardiomyopathy_Homo sapiens_hsa054140.30003021
148Mineral absorption_Homo sapiens_hsa049780.29569863
149Steroid biosynthesis_Homo sapiens_hsa001000.29167064
150Shigellosis_Homo sapiens_hsa051310.28786550
151Prion diseases_Homo sapiens_hsa050200.28336159
152Choline metabolism in cancer_Homo sapiens_hsa052310.26993945
153Rap1 signaling pathway_Homo sapiens_hsa040150.24050502
154Glucagon signaling pathway_Homo sapiens_hsa049220.23650932
155Proteasome_Homo sapiens_hsa030500.22593867
156Endometrial cancer_Homo sapiens_hsa052130.19475547
157Pertussis_Homo sapiens_hsa051330.19372045
158mTOR signaling pathway_Homo sapiens_hsa041500.19042740

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