ARMC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)4.55872224
2CENP-A containing nucleosome assembly (GO:0034080)4.49857914
3chromatin remodeling at centromere (GO:0031055)4.44888044
4mitotic metaphase plate congression (GO:0007080)4.29497213
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.18114935
6synaptic vesicle exocytosis (GO:0016079)4.16287907
7protein localization to chromosome, centromeric region (GO:0071459)4.15321717
8neuronal action potential propagation (GO:0019227)4.13205941
9metaphase plate congression (GO:0051310)4.07547889
10glutamate secretion (GO:0014047)4.07497218
11chaperone-mediated protein transport (GO:0072321)4.06638267
12neuron cell-cell adhesion (GO:0007158)4.01658841
13regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.01174219
14ATP synthesis coupled proton transport (GO:0015986)3.84433881
15energy coupled proton transport, down electrochemical gradient (GO:0015985)3.84433881
16vocalization behavior (GO:0071625)3.79036526
17protein localization to synapse (GO:0035418)3.78193969
18histone exchange (GO:0043486)3.76294062
19DNA double-strand break processing (GO:0000729)3.71998682
20kinetochore organization (GO:0051383)3.69406610
21regulation of synaptic vesicle exocytosis (GO:2000300)3.68828174
22establishment of chromosome localization (GO:0051303)3.68567016
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.65508906
24DNA replication-independent nucleosome assembly (GO:0006336)3.63193021
25DNA replication-independent nucleosome organization (GO:0034724)3.63193021
26mitotic sister chromatid cohesion (GO:0007064)3.61872812
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.60815753
28establishment of integrated proviral latency (GO:0075713)3.60715301
29DNA damage response, detection of DNA damage (GO:0042769)3.55009213
30regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.55008354
31regulation of short-term neuronal synaptic plasticity (GO:0048172)3.54515302
32DNA replication-dependent nucleosome organization (GO:0034723)3.51615324
33DNA replication-dependent nucleosome assembly (GO:0006335)3.51615324
34spindle checkpoint (GO:0031577)3.50583370
35nuclear pore organization (GO:0006999)3.48829058
36positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.46403591
37DNA ligation (GO:0006266)3.45792956
38respiratory electron transport chain (GO:0022904)3.36647542
39mitotic chromosome condensation (GO:0007076)3.36326657
40negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35945792
41mitotic spindle checkpoint (GO:0071174)3.34257527
42cullin deneddylation (GO:0010388)3.33498870
43protein localization to chromosome (GO:0034502)3.32648341
44sister chromatid segregation (GO:0000819)3.32580552
45attachment of spindle microtubules to kinetochore (GO:0008608)3.32561047
46regulation of meiosis I (GO:0060631)3.32469836
47presynaptic membrane assembly (GO:0097105)3.32361715
48nuclear pore complex assembly (GO:0051292)3.31657048
49regulation of glutamate receptor signaling pathway (GO:1900449)3.30582684
50establishment of protein localization to mitochondrial membrane (GO:0090151)3.28004999
51regulation of synaptic vesicle transport (GO:1902803)3.27948950
52proteasome assembly (GO:0043248)3.27678193
53electron transport chain (GO:0022900)3.27071567
54DNA strand elongation involved in DNA replication (GO:0006271)3.26397881
55ribosome assembly (GO:0042255)3.24956154
56mitotic sister chromatid segregation (GO:0000070)3.24139188
57regulation of centriole replication (GO:0046599)3.22718058
58synaptic vesicle maturation (GO:0016188)3.21834327
59double-strand break repair via nonhomologous end joining (GO:0006303)3.20651014
60non-recombinational repair (GO:0000726)3.20651014
61protein deneddylation (GO:0000338)3.20626674
62negative regulation of mitotic sister chromatid separation (GO:2000816)3.19626329
63negative regulation of sister chromatid segregation (GO:0033046)3.19626329
64negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.19626329
65negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.19626329
66negative regulation of mitotic sister chromatid segregation (GO:0033048)3.19626329
67regulation of long-term neuronal synaptic plasticity (GO:0048169)3.19392693
68response to pheromone (GO:0019236)3.19261197
69telomere maintenance via semi-conservative replication (GO:0032201)3.19119234
70regulation of acyl-CoA biosynthetic process (GO:0050812)3.18763642
71regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.18646452
72regulation of mitotic metaphase/anaphase transition (GO:0030071)3.18646452
73resolution of meiotic recombination intermediates (GO:0000712)3.18298725
74kinetochore assembly (GO:0051382)3.17000238
75synaptic vesicle docking involved in exocytosis (GO:0016081)3.16839552
76DNA strand elongation (GO:0022616)3.15886449
77regulation of mitotic sister chromatid separation (GO:0010965)3.14929943
78regulation of mitotic sister chromatid segregation (GO:0033047)3.14929943
79regulation of sister chromatid segregation (GO:0033045)3.14929943
80negative regulation of chromosome segregation (GO:0051985)3.14912731
81positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.14324628
82positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.14324628
83positive regulation of mitotic sister chromatid separation (GO:1901970)3.14324628
84regulation of cofactor metabolic process (GO:0051193)3.13903053
85regulation of coenzyme metabolic process (GO:0051196)3.13903053
86DNA replication checkpoint (GO:0000076)3.11616824
87regulation of chromosome segregation (GO:0051983)3.11225295
88positive regulation of chromosome segregation (GO:0051984)3.10896588
89neuron recognition (GO:0008038)3.09997324
90regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.09777204
91regulation of mitotic spindle checkpoint (GO:1903504)3.09777204
92neuron-neuron synaptic transmission (GO:0007270)3.09581369
93presynaptic membrane organization (GO:0097090)3.09367906
94gamma-aminobutyric acid signaling pathway (GO:0007214)3.08737510
95spindle assembly checkpoint (GO:0071173)3.05995512
96regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.05925658
97mitotic spindle assembly checkpoint (GO:0007094)3.05884880
98neurotransmitter secretion (GO:0007269)3.04719942
99mitotic recombination (GO:0006312)3.01756648
100neurotransmitter-gated ion channel clustering (GO:0072578)3.01337347
101glutamate receptor signaling pathway (GO:0007215)3.01283807
102establishment of mitochondrion localization (GO:0051654)3.00856495
103negative regulation of DNA-dependent DNA replication (GO:2000104)2.99187441
104locomotory exploration behavior (GO:0035641)2.98522491
105synaptic transmission, glutamatergic (GO:0035249)2.96292593
106ionotropic glutamate receptor signaling pathway (GO:0035235)2.95627808
107cerebellar granule cell differentiation (GO:0021707)2.94848741
108transmission of nerve impulse (GO:0019226)2.94792215
109synapsis (GO:0007129)2.93299272
110mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.91389465
111mitochondrial respiratory chain complex I assembly (GO:0032981)2.91389465
112NADH dehydrogenase complex assembly (GO:0010257)2.91389465
113negative regulation of DNA recombination (GO:0045910)2.90294733
114somatic diversification of immune receptors via somatic mutation (GO:0002566)2.89563499
115somatic hypermutation of immunoglobulin genes (GO:0016446)2.89563499
116regulation of neuronal synaptic plasticity (GO:0048168)2.89242209
117negative regulation of neurotransmitter transport (GO:0051589)2.87971472
118anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.85678219
119mitotic nuclear envelope disassembly (GO:0007077)2.82826248
120behavioral response to cocaine (GO:0048148)2.82717820
121regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.81330907
122neurotransmitter uptake (GO:0001504)2.81317652
123mitotic spindle organization (GO:0007052)2.81251925
124replication fork processing (GO:0031297)2.80722411
125telomere maintenance via recombination (GO:0000722)2.79749320
126substantia nigra development (GO:0021762)2.78238080
127regulation of spindle organization (GO:0090224)2.78202090
128DNA unwinding involved in DNA replication (GO:0006268)2.77085211
129negative regulation of microtubule polymerization (GO:0031115)2.76465605
130regulation of glutamate secretion (GO:0014048)2.76021446
131regulation of DNA endoreduplication (GO:0032875)2.75659380
132exploration behavior (GO:0035640)2.75126606
133histone H2A acetylation (GO:0043968)2.74645336
134nucleotide-excision repair, DNA gap filling (GO:0006297)2.74403758
135DNA topological change (GO:0006265)2.74345826
136regulation of centrosome cycle (GO:0046605)2.72539218
137protein K6-linked ubiquitination (GO:0085020)2.72436794
138chromosome segregation (GO:0007059)2.71838323
139behavioral defense response (GO:0002209)2.71720855
140behavioral fear response (GO:0001662)2.71720855
141centriole replication (GO:0007099)2.71169460
142mitotic G2/M transition checkpoint (GO:0044818)2.69795759
143microtubule depolymerization (GO:0007019)2.69600357
144regulation of dendritic spine morphogenesis (GO:0061001)2.69092158
145postreplication repair (GO:0006301)2.68776350
146neurotransmitter transport (GO:0006836)2.68522378
147positive regulation of membrane potential (GO:0045838)2.67647641
148mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.67551690
149protein complex biogenesis (GO:0070271)2.67383402
150nuclear envelope disassembly (GO:0051081)2.66570916
151membrane disassembly (GO:0030397)2.66570916
152regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.66530863
153transcription from mitochondrial promoter (GO:0006390)2.65967254
154telomere maintenance via telomere lengthening (GO:0010833)2.64186470
155regulation of excitatory postsynaptic membrane potential (GO:0060079)2.63132697
156regulation of helicase activity (GO:0051095)2.62386726
157regulation of DNA methylation (GO:0044030)2.62325491
158calcium-mediated signaling using intracellular calcium source (GO:0035584)2.62278214
159regulation of synaptic plasticity (GO:0048167)2.61989858
160long-term memory (GO:0007616)2.61764444
161long-term synaptic potentiation (GO:0060291)2.60551830
162ATP-dependent chromatin remodeling (GO:0043044)2.59937406
163positive regulation of synapse maturation (GO:0090129)2.59862083
164tricarboxylic acid cycle (GO:0006099)2.58731613
165DNA catabolic process, exonucleolytic (GO:0000738)2.57163273
166fear response (GO:0042596)2.57013316
167regulation of mitotic spindle organization (GO:0060236)2.55602772
168regulation of neurotransmitter levels (GO:0001505)2.54555204
169isotype switching (GO:0045190)2.53996472
170somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.53996472
171somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.53996472
172negative regulation of dendrite morphogenesis (GO:0050774)2.53624420
173organelle transport along microtubule (GO:0072384)2.52637772
174axonal fasciculation (GO:0007413)2.52608640
175ATP hydrolysis coupled proton transport (GO:0015991)2.52491234
176energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.52491234
177regulation of postsynaptic membrane potential (GO:0060078)2.51735482
178mitochondrial respiratory chain complex assembly (GO:0033108)2.51588366
179G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.51108137
180mitochondrion transport along microtubule (GO:0047497)2.50518536
181establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.50518536
182negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.48775208
183regulation of sulfur metabolic process (GO:0042762)2.46447918
184positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.46422136
185vesicle transport along microtubule (GO:0047496)2.45014750
186protein neddylation (GO:0045116)2.44422514
187gamma-aminobutyric acid transport (GO:0015812)2.43299810
188dendritic spine morphogenesis (GO:0060997)2.43012477
189central nervous system myelination (GO:0022010)2.42158462
190axon ensheathment in central nervous system (GO:0032291)2.42158462
191adult walking behavior (GO:0007628)2.41798431
192deoxyribose phosphate biosynthetic process (GO:0046385)2.40454899
1932-deoxyribonucleotide biosynthetic process (GO:0009265)2.40454899
194layer formation in cerebral cortex (GO:0021819)2.39065555
195establishment of protein localization to mitochondrion (GO:0072655)2.39025628
196protein localization to mitochondrion (GO:0070585)2.38953200
197protein targeting to mitochondrion (GO:0006626)2.38090370
198positive regulation of dendritic spine development (GO:0060999)2.37741765

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.89806206
2E2F7_22180533_ChIP-Seq_HELA_Human4.83528440
3GBX2_23144817_ChIP-Seq_PC3_Human3.46088643
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.38101116
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.24380187
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.98927689
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.86349119
8TAF15_26573619_Chip-Seq_HEK293_Human2.82650280
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.69556340
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.44495108
11ELK1_19687146_ChIP-ChIP_HELA_Human2.36174726
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.35047081
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19043727
14AR_21909140_ChIP-Seq_LNCAP_Human2.18598394
15* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.17758760
16FUS_26573619_Chip-Seq_HEK293_Human2.16922689
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.08317156
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04865714
19REST_21632747_ChIP-Seq_MESCs_Mouse2.04281116
20JARID2_20064375_ChIP-Seq_MESCs_Mouse2.03176725
21* PADI4_21655091_ChIP-ChIP_MCF-7_Human2.00642003
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.97189071
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.96882210
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94194643
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92426006
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88551183
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.86537046
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85698446
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80768924
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80232814
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.80011615
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79890470
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75375033
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.75143838
35* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.73547517
36P300_19829295_ChIP-Seq_ESCs_Human1.72133336
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70941450
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70615803
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69225227
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69098956
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63953522
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61740371
43VDR_22108803_ChIP-Seq_LS180_Human1.61496895
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.61169121
45* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60300197
46ZNF274_21170338_ChIP-Seq_K562_Hela1.60215381
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59849058
48* VDR_23849224_ChIP-Seq_CD4+_Human1.58158985
49PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.57251927
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55682805
51AR_21572438_ChIP-Seq_LNCaP_Human1.55563448
52EZH2_27304074_Chip-Seq_ESCs_Mouse1.55540725
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52851683
54* ETS1_20019798_ChIP-Seq_JURKAT_Human1.52007086
55EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49802967
56RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49802967
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.48120928
58EED_16625203_ChIP-ChIP_MESCs_Mouse1.45350222
59SMAD4_21799915_ChIP-Seq_A2780_Human1.44774120
60EWS_26573619_Chip-Seq_HEK293_Human1.44436685
61* FOXP3_21729870_ChIP-Seq_TREG_Human1.44298880
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.44192986
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43710549
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.42158805
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41026337
66MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40732231
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40383380
68CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40101006
69SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38282400
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36756916
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35424516
72JUN_21703547_ChIP-Seq_K562_Human1.35266987
73MYC_19079543_ChIP-ChIP_MESCs_Mouse1.34416406
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34059739
75* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.33974716
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33422537
77CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.32846585
78MYC_18555785_ChIP-Seq_MESCs_Mouse1.30071870
79SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.28997203
80* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27100235
81REST_19997604_ChIP-ChIP_NEURONS_Mouse1.25212652
82ER_23166858_ChIP-Seq_MCF-7_Human1.24907734
83IGF1R_20145208_ChIP-Seq_DFB_Human1.23773904
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21884866
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.19837522
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19263946
87GABP_19822575_ChIP-Seq_HepG2_Human1.19228411
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18755601
89BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18180259
90POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18084452
91POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18074363
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13949726
93HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13921024
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13626627
95PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12033373
96WT1_19549856_ChIP-ChIP_CCG9911_Human1.11821842
97TTF2_22483619_ChIP-Seq_HELA_Human1.10006422
98SOX9_26525672_Chip-Seq_HEART_Mouse1.08794356
99SOX2_21211035_ChIP-Seq_LN229_Gbm1.08180189
100* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08035522
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07323968
102NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07154607
103ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07035472
104NANOG_16153702_ChIP-ChIP_HESCs_Human1.06888889
105MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06100506
106STAT3_23295773_ChIP-Seq_U87_Human1.05490489
107CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04697211
108ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04400431
109* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04361251
110DCP1A_22483619_ChIP-Seq_HELA_Human1.02868626
111* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01739916
112IRF1_19129219_ChIP-ChIP_H3396_Human1.00020519
113RNF2_27304074_Chip-Seq_ESCs_Mouse0.98006473
114E2F4_17652178_ChIP-ChIP_JURKAT_Human0.97941774
115* AR_25329375_ChIP-Seq_VCAP_Human0.97532487
116* RNF2_27304074_Chip-Seq_NSC_Mouse0.97465201
117IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96765997
118CBP_20019798_ChIP-Seq_JUKART_Human0.96765997
119MYC_19030024_ChIP-ChIP_MESCs_Mouse0.96347787
120EZH2_27294783_Chip-Seq_NPCs_Mouse0.95373109
121EZH2_27294783_Chip-Seq_ESCs_Mouse0.94851407
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94648217
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94499440
124CBX2_27304074_Chip-Seq_ESCs_Mouse0.93992159
125SOX2_16153702_ChIP-ChIP_HESCs_Human0.93198777
126ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92991705
127NOTCH1_21737748_ChIP-Seq_TLL_Human0.92945970
128PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92586853
129* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92149675
130GATA1_26923725_Chip-Seq_HPCs_Mouse0.92140739
131PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91785260
132* PIAS1_25552417_ChIP-Seq_VCAP_Human0.91392340
133SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91147344
134KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90624629
135SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90275790
136E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90250242
137FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90117199
138SOX17_20123909_ChIP-Seq_XEN_Mouse0.90049748
139* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89370741
140MYC_18940864_ChIP-ChIP_HL60_Human0.89132451
141NANOG_18555785_Chip-Seq_ESCs_Mouse0.88255653
142MYCN_18555785_ChIP-Seq_MESCs_Mouse0.87546337
143RUNX2_22187159_ChIP-Seq_PCA_Human0.87327669
144ERG_21242973_ChIP-ChIP_JURKAT_Human0.87203263

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.33102257
2MP0004859_abnormal_synaptic_plasticity4.67151591
3MP0010094_abnormal_chromosome_stability3.51126658
4MP0008057_abnormal_DNA_replication3.32668481
5MP0004270_analgesia3.29908502
6MP0003635_abnormal_synaptic_transmissio3.29049026
7MP0008058_abnormal_DNA_repair3.15520304
8MP0003890_abnormal_embryonic-extraembry2.85700794
9MP0009745_abnormal_behavioral_response2.85561888
10MP0003693_abnormal_embryo_hatching2.81922977
11MP0002063_abnormal_learning/memory/cond2.69143187
12MP0001968_abnormal_touch/_nociception2.66895275
13MP0001529_abnormal_vocalization2.66699200
14MP0003111_abnormal_nucleus_morphology2.65271766
15MP0002064_seizures2.62685531
16MP0009046_muscle_twitch2.59683249
17MP0003077_abnormal_cell_cycle2.41064989
18MP0002272_abnormal_nervous_system2.38977382
19MP0006292_abnormal_olfactory_placode2.29288771
20MP0002734_abnormal_mechanical_nocicepti2.28451337
21MP0002572_abnormal_emotion/affect_behav2.28043174
22MP0002736_abnormal_nociception_after2.25606250
23MP0006276_abnormal_autonomic_nervous2.17937068
24MP0002735_abnormal_chemical_nociception2.09670839
25MP0008789_abnormal_olfactory_epithelium2.07504018
26MP0003329_amyloid_beta_deposits2.02389114
27MP0001440_abnormal_grooming_behavior2.01592183
28MP0010234_abnormal_vibrissa_follicle1.95520760
29MP0001486_abnormal_startle_reflex1.90392373
30MP0003941_abnormal_skin_development1.88164641
31MP0002234_abnormal_pharynx_morphology1.88100711
32MP0002067_abnormal_sensory_capabilities1.86676149
33MP0001905_abnormal_dopamine_level1.85964805
34MP0005423_abnormal_somatic_nervous1.84559192
35MP0004924_abnormal_behavior1.82081643
36MP0005386_behavior/neurological_phenoty1.82081643
37MP0005394_taste/olfaction_phenotype1.81637806
38MP0005499_abnormal_olfactory_system1.81637806
39MP0003122_maternal_imprinting1.78439664
40MP0000778_abnormal_nervous_system1.74088938
41MP0003123_paternal_imprinting1.70073090
42MP0004142_abnormal_muscle_tone1.66069205
43MP0001293_anophthalmia1.64107318
44MP0002733_abnormal_thermal_nociception1.61185611
45MP0002184_abnormal_innervation1.58567399
46MP0002822_catalepsy1.56797228
47MP0001970_abnormal_pain_threshold1.55627478
48MP0004147_increased_porphyrin_level1.51996985
49MP0003806_abnormal_nucleotide_metabolis1.50913381
50MP0010352_gastrointestinal_tract_polyps1.49373107
51MP0001501_abnormal_sleep_pattern1.46473576
52MP0001730_embryonic_growth_arrest1.43180589
53MP0005646_abnormal_pituitary_gland1.38876468
54MP0008007_abnormal_cellular_replicative1.37907550
55MP0001984_abnormal_olfaction1.37625267
56MP0000955_abnormal_spinal_cord1.37473755
57MP0006072_abnormal_retinal_apoptosis1.37163652
58MP0002751_abnormal_autonomic_nervous1.35486452
59MP0002066_abnormal_motor_capabilities/c1.35335081
60MP0002557_abnormal_social/conspecific_i1.34328542
61MP0003119_abnormal_digestive_system1.33514572
62MP0001188_hyperpigmentation1.31446034
63MP0006036_abnormal_mitochondrial_physio1.29662003
64MP0004811_abnormal_neuron_physiology1.29004826
65MP0008877_abnormal_DNA_methylation1.28378663
66MP0002210_abnormal_sex_determination1.27998051
67MP0003121_genomic_imprinting1.27421328
68MP0002837_dystrophic_cardiac_calcinosis1.27283121
69MP0002882_abnormal_neuron_morphology1.26135359
70MP0006035_abnormal_mitochondrial_morpho1.25542133
71MP0002233_abnormal_nose_morphology1.25424137
72MP0001929_abnormal_gametogenesis1.24898326
73MP0010030_abnormal_orbit_morphology1.22679876
74MP0001672_abnormal_embryogenesis/_devel1.20770894
75MP0005380_embryogenesis_phenotype1.20770894
76MP0001697_abnormal_embryo_size1.19992869
77MP0002084_abnormal_developmental_patter1.17750138
78MP0003937_abnormal_limbs/digits/tail_de1.17718365
79MP0003786_premature_aging1.16990021
80MP0001485_abnormal_pinna_reflex1.15766631
81MP0003755_abnormal_palate_morphology1.15536942
82MP0004145_abnormal_muscle_electrophysio1.13236727
83MP0003567_abnormal_fetal_cardiomyocyte1.12778030
84MP0008569_lethality_at_weaning1.11385213
85MP0002229_neurodegeneration1.11356981
86MP0000350_abnormal_cell_proliferation1.09450417
87MP0009697_abnormal_copulation1.09188239
88MP0003787_abnormal_imprinting1.09136709
89MP0004215_abnormal_myocardial_fiber1.09099411
90MP0010307_abnormal_tumor_latency1.08961707
91MP0002938_white_spotting1.08775463
92MP0002152_abnormal_brain_morphology1.07756340
93MP0002085_abnormal_embryonic_tissue1.07188897
94MP0001299_abnormal_eye_distance/1.05561719
95MP0004043_abnormal_pH_regulation1.05478753
96MP0003632_abnormal_nervous_system1.05473713
97MP0000653_abnormal_sex_gland1.04805135
98MP0000920_abnormal_myelination1.03867223
99MP0001145_abnormal_male_reproductive1.03558194
100MP0003631_nervous_system_phenotype1.02400223
101MP0005248_abnormal_Harderian_gland1.00497955
102MP0004885_abnormal_endolymph0.99672023
103MP0003718_maternal_effect0.99089119
104MP0002160_abnormal_reproductive_system0.98972608
105MP0003646_muscle_fatigue0.97995384
106MP0001286_abnormal_eye_development0.97669584
107MP0000647_abnormal_sebaceous_gland0.97595416
108MP0000427_abnormal_hair_cycle0.96657368
109MP0005551_abnormal_eye_electrophysiolog0.94932263
110MP0005395_other_phenotype0.94822665
111MP0004197_abnormal_fetal_growth/weight/0.93973773
112MP0005253_abnormal_eye_physiology0.93033311
113MP0003984_embryonic_growth_retardation0.92781517
114MP0001963_abnormal_hearing_physiology0.92411198
115MP0004233_abnormal_muscle_weight0.91085280
116MP0002088_abnormal_embryonic_growth/wei0.91068312
117MP0004133_heterotaxia0.90300979
118MP0005171_absent_coat_pigmentation0.89366689
119MP0002697_abnormal_eye_size0.89012034
120MP0002752_abnormal_somatic_nervous0.88040460
121MP0003879_abnormal_hair_cell0.87867256
122MP0004957_abnormal_blastocyst_morpholog0.87429858
123MP0005187_abnormal_penis_morphology0.87427707
124MP0003698_abnormal_male_reproductive0.86632634
125MP0009780_abnormal_chondrocyte_physiolo0.86606809
126MP0003633_abnormal_nervous_system0.86465041
127MP0002080_prenatal_lethality0.86407200
128MP0002090_abnormal_vision0.84287009
129MP0000049_abnormal_middle_ear0.84125952
130MP0002139_abnormal_hepatobiliary_system0.83924884
131MP0004085_abnormal_heartbeat0.83448812
132MP0001177_atelectasis0.82941345
133MP0008872_abnormal_physiological_respon0.81802695
134MP0000569_abnormal_digit_pigmentation0.81331371
135MP0005367_renal/urinary_system_phenotyp0.80359944
136MP0000516_abnormal_urinary_system0.80359944
137MP0005085_abnormal_gallbladder_physiolo0.79467574
138MP0000013_abnormal_adipose_tissue0.79435873
139MP0000604_amyloidosis0.78742406
140MP0002161_abnormal_fertility/fecundity0.78328704
141MP0005535_abnormal_body_temperature0.78125293
142MP0000358_abnormal_cell_content/0.77172905
143MP0004742_abnormal_vestibular_system0.75667490
144MP0005645_abnormal_hypothalamus_physiol0.75087793
145MP0003699_abnormal_female_reproductive0.75077078
146MP0008932_abnormal_embryonic_tissue0.75024010
147MP0003221_abnormal_cardiomyocyte_apopto0.74146259
148MP0003935_abnormal_craniofacial_develop0.73050253
149MP0000751_myopathy0.73003882
150MP0005391_vision/eye_phenotype0.72541108
151MP0002069_abnormal_eating/drinking_beha0.72404707
152MP0005332_abnormal_amino_acid0.72240201
153MP0010678_abnormal_skin_adnexa0.71934549
154MP0001119_abnormal_female_reproductive0.71637195
155MP0003385_abnormal_body_wall0.71615971
156MP0003634_abnormal_glial_cell0.71465217
157MP0003861_abnormal_nervous_system0.71118701
158MP0000631_abnormal_neuroendocrine_gland0.70882464
159MP0009703_decreased_birth_body0.68224991
160MP0005389_reproductive_system_phenotype0.67778202
161MP0002102_abnormal_ear_morphology0.64481219
162MP0005409_darkened_coat_color0.64228894
163MP0002638_abnormal_pupillary_reflex0.63917924
164MP0004858_abnormal_nervous_system0.63554925
165MP0004484_altered_response_of0.62515163
166MP0003195_calcinosis0.62035014
167MP0008875_abnormal_xenobiotic_pharmacok0.60746962
168MP0009379_abnormal_foot_pigmentation0.59844368
169MP0000747_muscle_weakness0.58380689
170MP0001502_abnormal_circadian_rhythm0.58244617

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.02487013
2Myokymia (HP:0002411)4.35869683
3Increased serum pyruvate (HP:0003542)4.31058475
4Abnormality of glycolysis (HP:0004366)4.31058475
5Acute necrotizing encephalopathy (HP:0006965)4.24141734
6Abnormal mitochondria in muscle tissue (HP:0008316)4.01704720
7Acute encephalopathy (HP:0006846)3.79718459
8Progressive macrocephaly (HP:0004481)3.70272965
9Atonic seizures (HP:0010819)3.60803565
10Pheochromocytoma (HP:0002666)3.59663643
11Hyperventilation (HP:0002883)3.57240082
12Epileptic encephalopathy (HP:0200134)3.44486116
13Neuroendocrine neoplasm (HP:0100634)3.42712788
14Mitochondrial inheritance (HP:0001427)3.38496320
15Volvulus (HP:0002580)3.33145231
16Focal seizures (HP:0007359)3.31655127
17Increased CSF lactate (HP:0002490)3.23068920
18Median cleft lip (HP:0000161)3.19252780
19Abnormality of chromosome stability (HP:0003220)3.15122242
20Chromsome breakage (HP:0040012)3.12776686
21Chromosomal breakage induced by crosslinking agents (HP:0003221)3.05219987
22Supernumerary spleens (HP:0009799)2.99453741
23Absence seizures (HP:0002121)2.95182237
24Hepatocellular necrosis (HP:0001404)2.94918130
25Papillary thyroid carcinoma (HP:0002895)2.94346723
26Meckel diverticulum (HP:0002245)2.92110508
27Degeneration of the lateral corticospinal tracts (HP:0002314)2.89602088
28Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.89602088
29Cerebral hypomyelination (HP:0006808)2.87327934
30Dialeptic seizures (HP:0011146)2.86131511
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.85996179
32Leukodystrophy (HP:0002415)2.84576291
33Visual hallucinations (HP:0002367)2.80423079
34Abnormality of the ileum (HP:0001549)2.79661688
35Cerebral edema (HP:0002181)2.79505694
36Abnormal lung lobation (HP:0002101)2.76755520
37Medulloblastoma (HP:0002885)2.73145375
38Colon cancer (HP:0003003)2.72018944
39Abnormality of the labia minora (HP:0012880)2.70885496
40Abnormality of the corticospinal tract (HP:0002492)2.68039258
41Termporal pattern (HP:0011008)2.66432256
42Insidious onset (HP:0003587)2.66432256
43Generalized tonic-clonic seizures (HP:0002069)2.64429901
44Broad-based gait (HP:0002136)2.64261139
45Cortical dysplasia (HP:0002539)2.60942273
46Increased hepatocellular lipid droplets (HP:0006565)2.60040167
47Septo-optic dysplasia (HP:0100842)2.59803552
48Nephroblastoma (Wilms tumor) (HP:0002667)2.54424443
49Abnormality of the preputium (HP:0100587)2.54333828
50Spastic gait (HP:0002064)2.53866811
51Abnormality of methionine metabolism (HP:0010901)2.52018450
52Delusions (HP:0000746)2.51507716
53Impaired vibration sensation in the lower limbs (HP:0002166)2.51433852
54Neoplasm of the peripheral nervous system (HP:0100007)2.50698576
55Ependymoma (HP:0002888)2.49504831
56Glioma (HP:0009733)2.48509676
57Hepatic necrosis (HP:0002605)2.48217514
58Lipid accumulation in hepatocytes (HP:0006561)2.44938290
59Embryonal renal neoplasm (HP:0011794)2.43820604
60Thyroid carcinoma (HP:0002890)2.39877724
61Abnormality of alanine metabolism (HP:0010916)2.39819965
62Hyperalaninemia (HP:0003348)2.39819965
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.39819965
64Anxiety (HP:0000739)2.39573714
65Short tibia (HP:0005736)2.38202801
66Lactic acidosis (HP:0003128)2.37149601
67Epileptiform EEG discharges (HP:0011182)2.35340482
68Drooling (HP:0002307)2.35139886
69Excessive salivation (HP:0003781)2.35139886
70Small intestinal stenosis (HP:0012848)2.30823129
71Duodenal stenosis (HP:0100867)2.30823129
72Abnormality of the astrocytes (HP:0100707)2.30174253
73Astrocytoma (HP:0009592)2.30174253
74Rhabdomyosarcoma (HP:0002859)2.28077023
75Exercise-induced muscle cramps (HP:0003710)2.26185088
76Facial cleft (HP:0002006)2.22936781
77Increased serum lactate (HP:0002151)2.22027545
78Dysdiadochokinesis (HP:0002075)2.21681298
79Aplasia/Hypoplasia of the tibia (HP:0005772)2.21389516
80Postnatal microcephaly (HP:0005484)2.21100233
81Gaze-evoked nystagmus (HP:0000640)2.19549678
82Urinary urgency (HP:0000012)2.18931765
83Respiratory failure (HP:0002878)2.18721851
84EEG with generalized epileptiform discharges (HP:0011198)2.18607584
85Progressive inability to walk (HP:0002505)2.18485378
86Abnormality of the septum pellucidum (HP:0007375)2.18319327
87Progressive cerebellar ataxia (HP:0002073)2.16280556
88X-linked dominant inheritance (HP:0001423)2.15842702
89Abnormality of aspartate family amino acid metabolism (HP:0010899)2.14672113
90Truncal ataxia (HP:0002078)2.13397578
91Hypsarrhythmia (HP:0002521)2.13031053
92Dysmetria (HP:0001310)2.11678861
93CNS hypomyelination (HP:0003429)2.09911752
94Absent septum pellucidum (HP:0001331)2.08824402
95Emotional lability (HP:0000712)2.08356442
96Sensory axonal neuropathy (HP:0003390)2.08259988
97Birth length less than 3rd percentile (HP:0003561)2.07072194
98Neoplasm of the adrenal gland (HP:0100631)2.06577924
99Abnormality of the duodenum (HP:0002246)2.05509016
100Optic disc pallor (HP:0000543)2.04561602
101Poor eye contact (HP:0000817)2.04444881
102Sloping forehead (HP:0000340)2.04227413
103Increased nuchal translucency (HP:0010880)2.03078592
104Limb dystonia (HP:0002451)2.01111972
105CNS demyelination (HP:0007305)2.00210886
106Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.99881556
107Exercise intolerance (HP:0003546)1.99018752
108Febrile seizures (HP:0002373)1.98823960
109Generalized myoclonic seizures (HP:0002123)1.97667543
110Ovarian neoplasm (HP:0100615)1.97202998
111Cerebral inclusion bodies (HP:0100314)1.96882331
112Retinal dysplasia (HP:0007973)1.96683724
113Urinary bladder sphincter dysfunction (HP:0002839)1.95752035
114Biliary tract neoplasm (HP:0100574)1.95209240
115Athetosis (HP:0002305)1.94584169
116Ankle clonus (HP:0011448)1.94452185
117Increased intramyocellular lipid droplets (HP:0012240)1.93015138
118Inability to walk (HP:0002540)1.92927557
119Facial hemangioma (HP:0000329)1.92816144
120Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91515420
121Progressive external ophthalmoplegia (HP:0000590)1.91315456
122Neoplasm of the colon (HP:0100273)1.90546333
123Breast carcinoma (HP:0003002)1.90140836
124Methylmalonic acidemia (HP:0002912)1.88980973
125Poor suck (HP:0002033)1.88610252
126Congenital primary aphakia (HP:0007707)1.88460504
127Abnormal eating behavior (HP:0100738)1.87464089
128Hyperglycinemia (HP:0002154)1.87175583
129Action tremor (HP:0002345)1.86717569
130Papilledema (HP:0001085)1.86523850
131Neoplasm of the adrenal cortex (HP:0100641)1.86204340
132Medial flaring of the eyebrow (HP:0010747)1.85738778
133Oligodactyly (hands) (HP:0001180)1.85577451
134Gait imbalance (HP:0002141)1.85182553
135Adrenal hypoplasia (HP:0000835)1.85150132
136Neurofibrillary tangles (HP:0002185)1.84783074
137Abnormal auditory evoked potentials (HP:0006958)1.84724858
138Absent speech (HP:0001344)1.84673366
139Hypoplastic pelvis (HP:0008839)1.84312483
140Wrist flexion contracture (HP:0001239)1.83011261
141Mesomelia (HP:0003027)1.82401139
142Delayed myelination (HP:0012448)1.82026014
143Scanning speech (HP:0002168)1.81693292
144Genital tract atresia (HP:0001827)1.81511856
145Optic nerve hypoplasia (HP:0000609)1.81244149
146Bifid tongue (HP:0010297)1.80886739
147Status epilepticus (HP:0002133)1.80560677
148Depression (HP:0000716)1.80008046
149Morphological abnormality of the pyramidal tract (HP:0002062)1.79752370
150Neoplasm of the small intestine (HP:0100833)1.79689009
151Nephrogenic diabetes insipidus (HP:0009806)1.79684525
152Abnormal hair whorl (HP:0010721)1.79115795
153Neoplasm of the oral cavity (HP:0100649)1.79077083
154Fetal akinesia sequence (HP:0001989)1.78469452
155Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.77290660
156Decreased activity of mitochondrial respiratory chain (HP:0008972)1.77290660
157Abnormal social behavior (HP:0012433)1.76928824
158Impaired social interactions (HP:0000735)1.76928824
159Small hand (HP:0200055)1.74570865
160Preaxial hand polydactyly (HP:0001177)1.74431700
161Microvesicular hepatic steatosis (HP:0001414)1.73461161
162Intestinal atresia (HP:0011100)1.73004102
163Degeneration of anterior horn cells (HP:0002398)1.71247848
164Abnormality of the anterior horn cell (HP:0006802)1.71247848
165Shoulder girdle muscle weakness (HP:0003547)1.69855449
166Embryonal neoplasm (HP:0002898)1.69719469
167Triphalangeal thumb (HP:0001199)1.69279643
168Hypoglycemic coma (HP:0001325)1.68891911
169Hepatoblastoma (HP:0002884)1.67595409
170Gonadotropin excess (HP:0000837)1.67414689
171Vaginal atresia (HP:0000148)1.66976351
172Aplasia/Hypoplasia of the sternum (HP:0006714)1.64373327
173Abnormality of the carotid arteries (HP:0005344)1.63686580
174Impulsivity (HP:0100710)1.63656397
175Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63000750
176Abnormality of serum amino acid levels (HP:0003112)1.62628172
177Abnormal sex determination (HP:0012244)1.60131647
178Sex reversal (HP:0012245)1.60131647
179Myelodysplasia (HP:0002863)1.58776551
180Type I transferrin isoform profile (HP:0003642)1.58717635
181Hypoglycemic seizures (HP:0002173)1.57925481
182Postaxial hand polydactyly (HP:0001162)1.56220066
183Absent radius (HP:0003974)1.56173757
184Multiple enchondromatosis (HP:0005701)1.54907556
185Overlapping toe (HP:0001845)1.54888554
186Tubulointerstitial nephritis (HP:0001970)1.54434239
187Hypoplastic labia majora (HP:0000059)1.52839545
188Cafe-au-lait spot (HP:0000957)1.52370418
189Clubbing of toes (HP:0100760)1.52049236
190Megaloblastic anemia (HP:0001889)1.49808006
191Postaxial foot polydactyly (HP:0001830)1.49532835

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.74546501
2EPHA43.57827038
3NTRK33.29274474
4CASK2.86413069
5MAP3K42.67232569
6SRPK12.62976370
7MINK12.55097673
8MAP2K72.50190533
9MAP3K92.31707369
10PNCK2.27054267
11MAP3K122.23973358
12BUB12.16163371
13MARK12.12158910
14MST42.05454858
15PLK21.97602423
16MAP2K41.90193942
17OXSR11.89439832
18ARAF1.88408286
19ERBB31.87810125
20BCR1.86605148
21CDK191.79921228
22EIF2AK11.74904685
23PLK41.63417181
24TAF11.59590423
25KSR11.59472537
26NUAK11.59234229
27KSR21.50959157
28LATS21.49106873
29ZAK1.46264236
30STK391.43677355
31BRAF1.43541032
32NEK11.34600554
33MAPK131.32250193
34DAPK21.31329859
35FRK1.30462411
36CDC71.29592011
37NTRK11.29429652
38DAPK11.27392962
39PAK61.25191336
40CCNB11.24467737
41PRPF4B1.22311236
42CDK141.18036701
43CAMK2B1.17062839
44WEE11.14530778
45PLK31.11438373
46TSSK61.10644955
47PRKD31.10130135
48UHMK11.08483414
49NME11.08130303
50PRKCG1.07770146
51MAP4K21.07724407
52BMPR21.07167243
53CDK181.05167328
54PDK41.04836973
55PDK31.04836973
56LIMK11.04448933
57CDK51.04351141
58CAMK2A1.03701282
59CSNK1G21.00365668
60CDK150.99117882
61TNIK0.96660447
62VRK10.95302221
63ATR0.93641602
64DYRK20.93186669
65RAF10.93070587
66BRSK10.92191234
67CSNK1G30.91527562
68PBK0.89567028
69SGK4940.86652996
70SGK2230.86652996
71TESK20.86192535
72CDK11A0.84397694
73EIF2AK20.83655194
74GRK50.82688982
75AURKB0.80455052
76CHEK20.80110091
77AKT30.79867625
78ATM0.77851140
79STK160.77735720
80MAP3K130.77286593
81PAK30.74009534
82AURKA0.73573977
83NTRK20.72824275
84STK30.70746529
85CAMK2D0.68290423
86ERBB40.65579076
87NEK90.64511668
88SCYL20.64301855
89MET0.63488141
90VRK20.63444700
91DYRK30.63258792
92CAMK2G0.62567633
93BCKDK0.61243557
94CDK90.60770052
95CHEK10.59016320
96CAMKK20.57216274
97STK240.57212380
98PHKG10.56644392
99PHKG20.56644392
100PRKCE0.56578763
101FGFR10.56234122
102ACVR1B0.55051881
103ABL20.53872546
104MKNK20.53362385
105WNK30.52428124
106CSNK1G10.51267257
107ROCK20.51018680
108STK38L0.50554494
109CDK80.49617896
110PTK2B0.48779772
111MKNK10.47794488
112CDK70.47121730
113CSNK1A1L0.46744412
114MAP3K60.46285539
115BMPR1B0.45955537
116CDK10.45620841
117FGR0.45185091
118TTK0.44878184
119SIK30.44654348
120PLK10.44579050
121NEK20.43237739
122DYRK1A0.43208012
123CAMKK10.42501088
124TGFBR10.41732331
125CDK20.41321066
126MOS0.41161428
127BRSK20.40974074
128FES0.40644570
129RPS6KA40.40267858
130CSNK1E0.40195952
131EIF2AK30.40185347
132RIPK40.40004032
133WNK40.39941751
134NEK60.39336920
135PINK10.39282245
136PASK0.39267604
137CDK30.37777412
138FER0.37544413
139PRKCI0.36853168
140FGFR20.34856998

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.05824800
2Non-homologous end-joining_Homo sapiens_hsa034503.05648786
3Nicotine addiction_Homo sapiens_hsa050333.04918672
4Parkinsons disease_Homo sapiens_hsa050122.69309866
5Synaptic vesicle cycle_Homo sapiens_hsa047212.53155107
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.33582370
7Homologous recombination_Homo sapiens_hsa034402.28461106
8Long-term potentiation_Homo sapiens_hsa047202.23588639
9Fanconi anemia pathway_Homo sapiens_hsa034602.20933586
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.11374846
11Proteasome_Homo sapiens_hsa030502.10183472
12GABAergic synapse_Homo sapiens_hsa047272.08164864
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05152356
14Alzheimers disease_Homo sapiens_hsa050102.01767715
15Amphetamine addiction_Homo sapiens_hsa050311.96194534
16Huntingtons disease_Homo sapiens_hsa050161.90412053
17RNA degradation_Homo sapiens_hsa030181.83655061
18Base excision repair_Homo sapiens_hsa034101.83150019
19Olfactory transduction_Homo sapiens_hsa047401.82814186
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.77837167
21Glutamatergic synapse_Homo sapiens_hsa047241.74788675
22Dopaminergic synapse_Homo sapiens_hsa047281.74757648
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.72678319
24Circadian entrainment_Homo sapiens_hsa047131.72601273
25Spliceosome_Homo sapiens_hsa030401.72013406
26Morphine addiction_Homo sapiens_hsa050321.71456082
27Collecting duct acid secretion_Homo sapiens_hsa049661.69598798
28Cardiac muscle contraction_Homo sapiens_hsa042601.67581288
29Oocyte meiosis_Homo sapiens_hsa041141.57932222
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47668902
31One carbon pool by folate_Homo sapiens_hsa006701.46684447
32Vitamin B6 metabolism_Homo sapiens_hsa007501.36716602
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35276858
34Pyruvate metabolism_Homo sapiens_hsa006201.34758668
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.34609529
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.33868714
37Serotonergic synapse_Homo sapiens_hsa047261.30863336
38Butanoate metabolism_Homo sapiens_hsa006501.29635057
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.29529881
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29087119
41Fatty acid elongation_Homo sapiens_hsa000621.27913331
42mRNA surveillance pathway_Homo sapiens_hsa030151.26436323
43Vibrio cholerae infection_Homo sapiens_hsa051101.25835992
44Long-term depression_Homo sapiens_hsa047301.24063120
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19881340
46Taste transduction_Homo sapiens_hsa047421.19231505
47Propanoate metabolism_Homo sapiens_hsa006401.17895929
48RNA polymerase_Homo sapiens_hsa030201.15115345
49p53 signaling pathway_Homo sapiens_hsa041151.13851222
50Protein export_Homo sapiens_hsa030601.12244976
51Salivary secretion_Homo sapiens_hsa049701.10649076
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.09637858
53Phototransduction_Homo sapiens_hsa047441.09545221
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08683079
55Insulin secretion_Homo sapiens_hsa049111.08682586
56Sulfur metabolism_Homo sapiens_hsa009201.06330298
57Selenocompound metabolism_Homo sapiens_hsa004501.05653015
58Cholinergic synapse_Homo sapiens_hsa047251.04615695
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03006337
60Carbon metabolism_Homo sapiens_hsa012001.02783717
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00576434
62Cocaine addiction_Homo sapiens_hsa050301.00482744
63Nitrogen metabolism_Homo sapiens_hsa009100.99728885
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99608433
65Biosynthesis of amino acids_Homo sapiens_hsa012300.95279660
66Gastric acid secretion_Homo sapiens_hsa049710.95115431
67Gap junction_Homo sapiens_hsa045400.93941876
68Renin secretion_Homo sapiens_hsa049240.93382549
69Calcium signaling pathway_Homo sapiens_hsa040200.89116926
70Oxytocin signaling pathway_Homo sapiens_hsa049210.85635389
71Folate biosynthesis_Homo sapiens_hsa007900.82429792
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77668631
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77033157
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76253454
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73645793
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72547041
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71354315
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71267123
79N-Glycan biosynthesis_Homo sapiens_hsa005100.70513193
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70455021
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67926067
82Axon guidance_Homo sapiens_hsa043600.66088446
83Melanogenesis_Homo sapiens_hsa049160.65247266
84Steroid biosynthesis_Homo sapiens_hsa001000.63906161
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63252425
86Mismatch repair_Homo sapiens_hsa034300.63023162
87Arginine biosynthesis_Homo sapiens_hsa002200.60615184
88Circadian rhythm_Homo sapiens_hsa047100.60037973
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.59858274
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59592896
91Glutathione metabolism_Homo sapiens_hsa004800.58966778
92GnRH signaling pathway_Homo sapiens_hsa049120.58886412
93Hippo signaling pathway_Homo sapiens_hsa043900.58623019
94Basal transcription factors_Homo sapiens_hsa030220.57535789
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57174256
96RNA transport_Homo sapiens_hsa030130.56995223
97TGF-beta signaling pathway_Homo sapiens_hsa043500.55907996
98Alcoholism_Homo sapiens_hsa050340.55276886
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53577497
100Purine metabolism_Homo sapiens_hsa002300.51240289
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50779033
102Glioma_Homo sapiens_hsa052140.50696741
103cAMP signaling pathway_Homo sapiens_hsa040240.49961226
104Thyroid hormone synthesis_Homo sapiens_hsa049180.47649446
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.47634900
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47465236
107DNA replication_Homo sapiens_hsa030300.47424850
108Estrogen signaling pathway_Homo sapiens_hsa049150.47342867
109Wnt signaling pathway_Homo sapiens_hsa043100.45045692
110Fatty acid metabolism_Homo sapiens_hsa012120.45044595
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43742909
112Hedgehog signaling pathway_Homo sapiens_hsa043400.43526536
113Metabolic pathways_Homo sapiens_hsa011000.43025081
114Glucagon signaling pathway_Homo sapiens_hsa049220.42658395
115Cell cycle_Homo sapiens_hsa041100.42205975
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41298344
117ErbB signaling pathway_Homo sapiens_hsa040120.41243168
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40612533
119Peroxisome_Homo sapiens_hsa041460.37014274
120Pyrimidine metabolism_Homo sapiens_hsa002400.36201728
121Regulation of autophagy_Homo sapiens_hsa041400.35307961
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34993721
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34646461
124Nucleotide excision repair_Homo sapiens_hsa034200.34110948
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.33103127
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30855048
127Caffeine metabolism_Homo sapiens_hsa002320.30621424
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30456703
129beta-Alanine metabolism_Homo sapiens_hsa004100.30361386
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30043146
131Arginine and proline metabolism_Homo sapiens_hsa003300.29248370
132Colorectal cancer_Homo sapiens_hsa052100.28882334
133Adherens junction_Homo sapiens_hsa045200.26586236
134Thyroid cancer_Homo sapiens_hsa052160.24512854
135Pentose phosphate pathway_Homo sapiens_hsa000300.24189871
136Tight junction_Homo sapiens_hsa045300.22785032
137AMPK signaling pathway_Homo sapiens_hsa041520.21049393
138MicroRNAs in cancer_Homo sapiens_hsa052060.21047296
139Fatty acid degradation_Homo sapiens_hsa000710.19363776

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