ARMC10P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral mRNA export from host cell nucleus (GO:0046784)5.74443525
2proteasome assembly (GO:0043248)5.53719152
3establishment of integrated proviral latency (GO:0075713)4.98090449
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.95888865
5maturation of 5.8S rRNA (GO:0000460)4.88214182
6protein maturation by protein folding (GO:0022417)4.72603283
7ribosomal large subunit biogenesis (GO:0042273)4.51102023
8peroxisome fission (GO:0016559)4.49957291
9ribonucleoprotein complex disassembly (GO:0032988)4.49653010
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.43636384
11organelle disassembly (GO:1903008)4.38805911
12ribosome assembly (GO:0042255)4.25000964
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.19189660
14ATP synthesis coupled proton transport (GO:0015986)4.19016099
15energy coupled proton transport, down electrochemical gradient (GO:0015985)4.19016099
16chaperone-mediated protein transport (GO:0072321)4.14383579
17establishment of viral latency (GO:0019043)4.10300453
18interferon-gamma production (GO:0032609)4.04390523
19cullin deneddylation (GO:0010388)3.95372296
20negative regulation of ligase activity (GO:0051352)3.91907791
21negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.91907791
22regulation of cellular amino acid metabolic process (GO:0006521)3.90290028
23cellular response to arsenic-containing substance (GO:0071243)3.89937614
24positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.83167082
25oxidative phosphorylation (GO:0006119)3.80243593
26DNA damage response, detection of DNA damage (GO:0042769)3.79920557
27regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.78782881
28protein deneddylation (GO:0000338)3.67597375
29DNA replication checkpoint (GO:0000076)3.66663187
30regulation of mitotic spindle checkpoint (GO:1903504)3.62130561
31regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.62130561
32DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.56941055
33mitochondrial RNA metabolic process (GO:0000959)3.56334824
34signal transduction involved in DNA damage checkpoint (GO:0072422)3.54600221
35signal transduction involved in DNA integrity checkpoint (GO:0072401)3.54600221
36intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.54000107
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.54000107
38signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.50684130
39signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.50684130
40signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.50684130
41anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.50143255
42intracellular protein transmembrane import (GO:0044743)3.50093022
43signal transduction involved in cell cycle checkpoint (GO:0072395)3.47431675
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.46865079
45termination of RNA polymerase III transcription (GO:0006386)3.46865079
46CENP-A containing nucleosome assembly (GO:0034080)3.45288139
47tRNA methylation (GO:0030488)3.44572070
48protein targeting to mitochondrion (GO:0006626)3.37535595
49DNA ligation (GO:0006266)3.37270590
50formation of translation preinitiation complex (GO:0001731)3.34213760
51protein localization to mitochondrion (GO:0070585)3.28757806
52establishment of protein localization to mitochondrion (GO:0072655)3.27976386
53deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.26638556
54histone mRNA metabolic process (GO:0008334)3.21624337
55spliceosomal snRNP assembly (GO:0000387)3.21605527
56tRNA aminoacylation (GO:0043039)3.21560291
57amino acid activation (GO:0043038)3.21560291
58positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.20567313
59chromatin remodeling at centromere (GO:0031055)3.20107449
60positive regulation of mitochondrial fission (GO:0090141)3.17407533
61tRNA aminoacylation for protein translation (GO:0006418)3.17060390
62positive regulation of ligase activity (GO:0051351)3.16215005
63antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.11841531
64mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.10463586
65AMP metabolic process (GO:0046033)3.07600118
66regulation of centriole replication (GO:0046599)3.04837474
67respiratory electron transport chain (GO:0022904)3.00308555
68DNA topological change (GO:0006265)2.99910688
69tRNA metabolic process (GO:0006399)2.94237061
70electron transport chain (GO:0022900)2.93586834
71de novo protein folding (GO:0006458)2.93298949
72mitochondrial transport (GO:0006839)2.92792976
73cellular component biogenesis (GO:0044085)2.92200365
74regulation of ubiquitin-protein transferase activity (GO:0051438)2.92069179
75antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.91347977
76ribosome biogenesis (GO:0042254)2.90208049
77regulation of ligase activity (GO:0051340)2.89699372
78inner mitochondrial membrane organization (GO:0007007)2.89421432
79cellular respiration (GO:0045333)2.87002751
80tRNA modification (GO:0006400)2.86673562
81mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86265314
82mitochondrial respiratory chain complex I assembly (GO:0032981)2.86265314
83NADH dehydrogenase complex assembly (GO:0010257)2.86265314
84tRNA processing (GO:0008033)2.84894678
85non-recombinational repair (GO:0000726)2.84321087
86double-strand break repair via nonhomologous end joining (GO:0006303)2.84321087
87ribonucleoprotein complex biogenesis (GO:0022613)2.81873902
88intracellular protein transmembrane transport (GO:0065002)2.81161200
89translation (GO:0006412)2.80065629
90mitochondrial fission (GO:0000266)2.78741608
91dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.77974483
92nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.77968818
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.74669595
94purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.74282578
95negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.73385474
96regulation of cellular amine metabolic process (GO:0033238)2.72762372
97transcription from mitochondrial promoter (GO:0006390)2.72135280
98polyamine biosynthetic process (GO:0006596)2.71718534
99regulation of helicase activity (GO:0051095)2.71390350
100establishment of protein localization to peroxisome (GO:0072663)2.71331932

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.78710021
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.13296448
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.96279748
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.91660913
5E2F7_22180533_ChIP-Seq_HELA_Human3.84794703
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.59726449
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.39577587
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.24683501
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.05027436
10VDR_23849224_ChIP-Seq_CD4+_Human2.97036297
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.95981937
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.89847323
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89642063
14PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.86091916
15ELK1_19687146_ChIP-ChIP_HELA_Human2.84658976
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.82409063
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72109480
18DCP1A_22483619_ChIP-Seq_HELA_Human2.67911743
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.64282487
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.62761791
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.60522311
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.45488759
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.40708901
24FOXP3_21729870_ChIP-Seq_TREG_Human2.39528477
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.36887137
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.35429406
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.24486697
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.24485076
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.09104911
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07269010
31MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04472621
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02314865
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94761336
34TTF2_22483619_ChIP-Seq_HELA_Human1.86896064
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.85504597
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81935709
37GABP_19822575_ChIP-Seq_HepG2_Human1.81339415
38EWS_26573619_Chip-Seq_HEK293_Human1.72301184
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.72079680
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65362464
41XRN2_22483619_ChIP-Seq_HELA_Human1.61937312
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61350535
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61205714
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55307515
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51042344
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47434889
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.46270364
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45740171
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.43003051
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39764283
51IGF1R_20145208_ChIP-Seq_DFB_Human1.36276289
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34783668
53TFEB_21752829_ChIP-Seq_HELA_Human1.34694922
54ELK1_22589737_ChIP-Seq_MCF10A_Human1.33458768
55KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32615207
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.32094680
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31893334
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.30979655
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28206994
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.27450362
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.22703598
62VDR_22108803_ChIP-Seq_LS180_Human1.21220364
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20510230
64CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.19055098
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17993761
66MYC_18940864_ChIP-ChIP_HL60_Human1.17800637
67SOX17_20123909_ChIP-Seq_XEN_Mouse1.17635990
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.17292143
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13664465
70IRF1_19129219_ChIP-ChIP_H3396_Human1.11838164
71NANOG_16153702_ChIP-ChIP_HESCs_Human1.10720921
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09899994
73AR_21909140_ChIP-Seq_LNCAP_Human1.09091557
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08962821
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07390780
76PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06783592
77PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.04782039
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04655139
79KDM5A_27292631_Chip-Seq_BREAST_Human1.04465957
80TAF15_26573619_Chip-Seq_HEK293_Human1.04265164
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03793878
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02617658
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01966161
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00902884
85SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94674814
86ELF5_23300383_ChIP-Seq_T47D_Human0.92479797
87CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90928646
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88042436
89ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87284741
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85505502
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85298010
92ZNF274_21170338_ChIP-Seq_K562_Hela0.84666165
93CIITA_25753668_ChIP-Seq_RAJI_Human0.82911229
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80623993
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80437471
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80117922
97FUS_26573619_Chip-Seq_HEK293_Human0.77367689
98POU3F2_20337985_ChIP-ChIP_501MEL_Human0.77115303
99TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.76544109
100SPI1_23547873_ChIP-Seq_NB4_Human0.75101038

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis6.40357343
2MP0004957_abnormal_blastocyst_morpholog4.10800481
3MP0008058_abnormal_DNA_repair3.87545772
4MP0010094_abnormal_chromosome_stability3.57934422
5MP0004147_increased_porphyrin_level3.41540433
6MP0010368_abnormal_lymphatic_system3.32122951
7MP0003693_abnormal_embryo_hatching3.16239898
8MP0006054_spinal_hemorrhage3.04340352
9MP0001529_abnormal_vocalization2.99723224
10MP0005167_abnormal_blood-brain_barrier2.95797097
11MP0003941_abnormal_skin_development2.42911853
12MP0003786_premature_aging2.32806152
13MP0003718_maternal_effect2.28909048
14MP0009697_abnormal_copulation2.21270071
15MP0006036_abnormal_mitochondrial_physio2.14088242
16MP0006035_abnormal_mitochondrial_morpho1.92951432
17MP0003077_abnormal_cell_cycle1.87820205
18MP0008007_abnormal_cellular_replicative1.86419103
19MP0004782_abnormal_surfactant_physiolog1.81427941
20MP0003656_abnormal_erythrocyte_physiolo1.81295573
21MP0008932_abnormal_embryonic_tissue1.80097886
22MP0002234_abnormal_pharynx_morphology1.79334800
23MP0008057_abnormal_DNA_replication1.73429573
24MP0003828_pulmonary_edema1.66946879
25MP0003111_abnormal_nucleus_morphology1.58421511
26MP0001542_abnormal_bone_strength1.56011052
27MP0003186_abnormal_redox_activity1.54826949
28MP0002332_abnormal_exercise_endurance1.52370099
29MP0003950_abnormal_plasma_membrane1.45350575
30MP0001730_embryonic_growth_arrest1.42743809
31MP0002160_abnormal_reproductive_system1.38159274
32MP0003221_abnormal_cardiomyocyte_apopto1.32361057
33MP0005266_abnormal_metabolism1.31175669
34MP0006072_abnormal_retinal_apoptosis1.29465709
35MP0000358_abnormal_cell_content/1.29317052
36MP0004084_abnormal_cardiac_muscle1.26724494
37MP0001835_abnormal_antigen_presentation1.25770730
38MP0004215_abnormal_myocardial_fiber1.24880197
39MP0002132_abnormal_respiratory_system1.23376656
40MP0002877_abnormal_melanocyte_morpholog1.22922174
41MP0002102_abnormal_ear_morphology1.21732594
42MP0005084_abnormal_gallbladder_morpholo1.21671647
43MP0003890_abnormal_embryonic-extraembry1.18825141
44MP0001727_abnormal_embryo_implantation1.15965594
45MP0001672_abnormal_embryogenesis/_devel1.15291440
46MP0005380_embryogenesis_phenotype1.15291440
47MP0003315_abnormal_perineum_morphology1.10273668
48MP0008775_abnormal_heart_ventricle1.09996248
49MP0008875_abnormal_xenobiotic_pharmacok1.09470235
50MP0000350_abnormal_cell_proliferation1.08699492
51MP0003868_abnormal_feces_composition1.04681981
52MP0000343_altered_response_to0.99475034
53MP0001697_abnormal_embryo_size0.99143752
54MP0005367_renal/urinary_system_phenotyp0.98405565
55MP0000516_abnormal_urinary_system0.98405565
56MP0001879_abnormal_lymphatic_vessel0.98056675
57MP0002006_tumorigenesis0.96776544
58MP0001756_abnormal_urination0.96645310
59MP0006138_congestive_heart_failure0.96536298
60MP0009764_decreased_sensitivity_to0.96191274
61MP0002080_prenatal_lethality0.94739077
62MP0003075_altered_response_to0.93984559
63MP0002084_abnormal_developmental_patter0.93030052
64MP0003123_paternal_imprinting0.92086055
65MP0003119_abnormal_digestive_system0.92039337
66MP0003984_embryonic_growth_retardation0.91683318
67MP0000490_abnormal_crypts_of0.91143608
68MP0003567_abnormal_fetal_cardiomyocyte0.91128091
69MP0005671_abnormal_response_to0.90090391
70MP0002090_abnormal_vision0.89295972
71MP0000747_muscle_weakness0.88655387
72MP0002088_abnormal_embryonic_growth/wei0.87917481
73MP0000313_abnormal_cell_death0.87696735
74MP0002060_abnormal_skin_morphology0.87468313
75MP0002166_altered_tumor_susceptibility0.85967780
76MP0008873_increased_physiological_sensi0.85073786
77MP0001915_intracranial_hemorrhage0.84829948
78MP0009672_abnormal_birth_weight0.83079201
79MP0004272_abnormal_basement_membrane0.75509291
80MP0002210_abnormal_sex_determination0.73321658
81MP0002295_abnormal_pulmonary_circulatio0.70519917
82MP0008872_abnormal_physiological_respon0.70032600
83MP0005332_abnormal_amino_acid0.69965525
84MP0005636_abnormal_mineral_homeostasis0.69137979
85MP0005075_abnormal_melanosome_morpholog0.68808907
86MP0000579_abnormal_nail_morphology0.68465492
87MP0001145_abnormal_male_reproductive0.68369350
88MP0005410_abnormal_fertilization0.65876455
89MP0009765_abnormal_xenobiotic_induced0.63462650
90MP0001661_extended_life_span0.63054560
91MP0002127_abnormal_cardiovascular_syste0.62690626
92MP0002086_abnormal_extraembryonic_tissu0.61733024
93MP0001293_anophthalmia0.61626458
94MP0001764_abnormal_homeostasis0.60880048
95MP0002085_abnormal_embryonic_tissue0.59203354
96MP0005376_homeostasis/metabolism_phenot0.58810314
97MP0003011_delayed_dark_adaptation0.57661717
98MP0001929_abnormal_gametogenesis0.56538003
99MP0001881_abnormal_mammary_gland0.55871179
100MP0004142_abnormal_muscle_tone0.55537535

Predicted human phenotypes

RankGene SetZ-score
1Decreased circulating renin level (HP:0003351)5.31473400
2Increased hepatocellular lipid droplets (HP:0006565)4.94051214
3Lipid accumulation in hepatocytes (HP:0006561)4.74613632
4Acute necrotizing encephalopathy (HP:0006965)3.78456463
5Renal Fanconi syndrome (HP:0001994)3.69693376
6Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.68184349
7Abnormality of alanine metabolism (HP:0010916)3.68184349
8Hyperalaninemia (HP:0003348)3.68184349
9Type I transferrin isoform profile (HP:0003642)3.67331557
10Abnormal mitochondria in muscle tissue (HP:0008316)3.61225642
11Mitochondrial inheritance (HP:0001427)3.60831961
12Hepatocellular necrosis (HP:0001404)3.59797493
13Increased intramyocellular lipid droplets (HP:0012240)3.51867698
14Increased serum lactate (HP:0002151)3.49918647
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.44689837
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.44689837
17Congenital, generalized hypertrichosis (HP:0004540)3.44238847
18Increased CSF lactate (HP:0002490)3.43977742
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.39661254
20Palpitations (HP:0001962)3.30629038
21Cerebral edema (HP:0002181)3.24071490
22Acute encephalopathy (HP:0006846)3.15136985
23Hepatic necrosis (HP:0002605)3.14678520
24Lactic acidosis (HP:0003128)3.08108565
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.01495231
26Neonatal onset (HP:0003623)2.98615783
27Exertional dyspnea (HP:0002875)2.98085809
28Increased muscle lipid content (HP:0009058)2.96347347
29Progressive macrocephaly (HP:0004481)2.93034946
30Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.91849720
31Polydipsia (HP:0001959)2.88914656
32Abnormal drinking behavior (HP:0030082)2.88914656
33Reduced antithrombin III activity (HP:0001976)2.86506498
34Abnormal protein glycosylation (HP:0012346)2.85343495
35Abnormal glycosylation (HP:0012345)2.85343495
36Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.85343495
37Abnormal protein N-linked glycosylation (HP:0012347)2.85343495
38Tongue fasciculations (HP:0001308)2.82596477
39Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.79627054
40Dry hair (HP:0011359)2.78696081
41Hyponatremia (HP:0002902)2.78548775
42Abnormality of renin-angiotensin system (HP:0000847)2.75395023
43Exercise intolerance (HP:0003546)2.74891457
44Abnormality of methionine metabolism (HP:0010901)2.64679225
45Brushfield spots (HP:0001088)2.62460803
46Onycholysis (HP:0001806)2.46965125
47Respiratory difficulties (HP:0002880)2.46538281
48Progressive muscle weakness (HP:0003323)2.46150866
49Abnormality of renal resorption (HP:0011038)2.43569539
50Vertebral compression fractures (HP:0002953)2.43561088
51Muscle fibrillation (HP:0010546)2.43021562
52Ketoacidosis (HP:0001993)2.36052206
53Multiple enchondromatosis (HP:0005701)2.31010988
54Microvesicular hepatic steatosis (HP:0001414)2.30747143
55Increased serum pyruvate (HP:0003542)2.30331158
56Upper limb muscle weakness (HP:0003484)2.27564965
57Bile duct proliferation (HP:0001408)2.20198293
58Abnormal biliary tract physiology (HP:0012439)2.20198293
59Sensory axonal neuropathy (HP:0003390)2.19980012
60Cortical visual impairment (HP:0100704)2.19149006
61Short tibia (HP:0005736)2.18890016
62Abnormality of serum amino acid levels (HP:0003112)2.17625599
63Rough bone trabeculation (HP:0100670)2.14757352
64Oral leukoplakia (HP:0002745)2.11850578
65Death in infancy (HP:0001522)2.11552482
66Lethargy (HP:0001254)2.07094373
67Leukodystrophy (HP:0002415)2.05177695
68Chronic bronchitis (HP:0004469)2.04736539
69CNS demyelination (HP:0007305)2.03385673
70Respiratory failure (HP:0002878)2.00368061
71Ragged-red muscle fibers (HP:0003200)1.93104150
72Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92223622
73Polyuria (HP:0000103)1.90917640
74Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.89839289
75Trismus (HP:0000211)1.89249797
76Opisthotonus (HP:0002179)1.89170604
77Abnormality of the pons (HP:0007361)1.88761243
78Abolished electroretinogram (ERG) (HP:0000550)1.88433146
79Abnormal respiratory motile cilium physiology (HP:0012261)1.85638658
80Female pseudohermaphroditism (HP:0010458)1.85383876
81Fasciculations (HP:0002380)1.84936023
82Primary adrenal insufficiency (HP:0008207)1.84853006
83Tetraparesis (HP:0002273)1.83121902
84Epiphyseal stippling (HP:0010655)1.80897140
85Abnormality of secondary sexual hair (HP:0009888)1.79525161
86Abnormality of the axillary hair (HP:0100134)1.79525161
87Sparse eyelashes (HP:0000653)1.78144863
88Abnormality of sodium homeostasis (HP:0010931)1.77393677
89Neoplasm of the rectum (HP:0100743)1.77174037
90Abnormality of the anterior horn cell (HP:0006802)1.75707418
91Degeneration of anterior horn cells (HP:0002398)1.75707418
92Aplasia/Hypoplasia of the tibia (HP:0005772)1.74178430
93Abnormal ciliary motility (HP:0012262)1.72384352
94Symptomatic seizures (HP:0011145)1.71145998
95Congenital ichthyosiform erythroderma (HP:0007431)1.70857622
96Abnormality of glycolysis (HP:0004366)1.70384961
97Hyperphosphaturia (HP:0003109)1.69265116
98Horseshoe kidney (HP:0000085)1.69264193
99Rhinitis (HP:0012384)1.69128639
100Abnormal number of erythroid precursors (HP:0012131)1.67257484

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.44965579
2MAP4K24.41569154
3EIF2AK33.78284177
4TSSK63.45481693
5STK163.31046992
6SRPK12.67926507
7MST42.48619136
8NEK12.46751696
9BUB12.42503986
10MAP3K122.40099804
11EIF2AK12.28424437
12TEC2.08840950
13LIMK11.97718968
14ARAF1.81714528
15TESK11.79937759
16SCYL21.73454013
17VRK21.67627856
18PASK1.62983306
19GRK11.61989792
20MOS1.57342474
21BMPR21.55635417
22STK241.53718213
23BCKDK1.50240161
24PLK41.49296722
25CDK191.43953642
26TGFBR21.42481940
27CDC71.37086808
28TRIM281.36516172
29MKNK11.36098073
30STK38L1.26634128
31WEE11.24202835
32EIF2AK21.17248740
33OXSR11.17198927
34ERBB31.16652533
35BRSK21.12487954
36BLK1.06504394
37MAPKAPK31.05894623
38ALK1.03720465
39CDK80.98406045
40ERBB40.95132451
41PLK30.94727567
42TGFBR10.91212903
43ZAK0.89524897
44STK390.88272494
45GRK70.85714150
46TESK20.84787422
47TRPM70.83882603
48MKNK20.83072513
49MYLK0.83072210
50PAK40.82725385
51TTK0.82371345
52VRK10.75674062
53RPS6KB20.74076620
54WNK40.69575180
55TLK10.67384845
56PIM20.65277844
57PBK0.63229519
58NUAK10.63198923
59CDK70.62680187
60BRAF0.61118464
61KDR0.60562023
62NME10.59938692
63YES10.59539255
64TAF10.57324626
65BMPR1B0.56650477
66NME20.55300712
67CSNK1A1L0.54307024
68MST1R0.51925348
69MAPKAPK50.51563133
70CCNB10.51494503
71AURKB0.50621875
72CSNK1G30.50182675
73DAPK10.48420503
74IRAK40.47639695
75ILK0.45664997
76TAOK20.44134119
77RPS6KA50.41087083
78CSNK1G10.40960199
79DYRK30.39006565
80PLK10.38545693
81EGFR0.37743674
82STK100.36779145
83CSNK2A10.36399803
84MAP3K40.36056987
85BRSK10.35992992
86MAP3K140.35964693
87CSNK2A20.34837498
88TNIK0.34727862
89CSNK1G20.33823986
90DAPK30.33751823
91ABL20.33351825
92MAP2K70.33090808
93TBK10.32453840
94ITK0.32278205
95AURKA0.31097862
96STK30.28748906
97MAP3K50.28650766
98EEF2K0.28088867
99IRAK30.25965546
100LATS20.25610049

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.17821893
2Protein export_Homo sapiens_hsa030604.13622996
3Oxidative phosphorylation_Homo sapiens_hsa001903.22508712
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.02802410
5RNA polymerase_Homo sapiens_hsa030203.00874577
6Non-homologous end-joining_Homo sapiens_hsa034502.81515136
7Parkinsons disease_Homo sapiens_hsa050122.78379076
8Ribosome_Homo sapiens_hsa030102.59257769
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.52567310
10DNA replication_Homo sapiens_hsa030302.39907549
11Spliceosome_Homo sapiens_hsa030402.25095468
12RNA transport_Homo sapiens_hsa030132.03775893
13One carbon pool by folate_Homo sapiens_hsa006701.92765089
14Mismatch repair_Homo sapiens_hsa034301.92093970
15Huntingtons disease_Homo sapiens_hsa050161.91308079
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.84877865
17Base excision repair_Homo sapiens_hsa034101.82638674
18Nucleotide excision repair_Homo sapiens_hsa034201.81820019
19Asthma_Homo sapiens_hsa053101.81724134
20Alzheimers disease_Homo sapiens_hsa050101.81612767
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73756498
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.73156017
23Pyrimidine metabolism_Homo sapiens_hsa002401.59583321
24Sulfur relay system_Homo sapiens_hsa041221.40187138
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.36838388
26RNA degradation_Homo sapiens_hsa030181.36402882
27Antigen processing and presentation_Homo sapiens_hsa046121.34414112
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.30271024
29Homologous recombination_Homo sapiens_hsa034401.27793318
30Cardiac muscle contraction_Homo sapiens_hsa042601.25080985
31Basal transcription factors_Homo sapiens_hsa030221.20895694
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19871685
33Purine metabolism_Homo sapiens_hsa002301.19307788
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18672415
35Cell cycle_Homo sapiens_hsa041101.16359500
36Glutathione metabolism_Homo sapiens_hsa004801.15202527
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08018243
38Allograft rejection_Homo sapiens_hsa053301.07038258
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05405794
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05389279
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02375391
42Graft-versus-host disease_Homo sapiens_hsa053321.01655326
43Rheumatoid arthritis_Homo sapiens_hsa053231.01584934
44Autoimmune thyroid disease_Homo sapiens_hsa053200.98005454
45Folate biosynthesis_Homo sapiens_hsa007900.97048939
46Systemic lupus erythematosus_Homo sapiens_hsa053220.95839066
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95817207
48Pyruvate metabolism_Homo sapiens_hsa006200.92264268
49N-Glycan biosynthesis_Homo sapiens_hsa005100.90518797
50Viral myocarditis_Homo sapiens_hsa054160.90370319
51Type I diabetes mellitus_Homo sapiens_hsa049400.90005568
52Fatty acid elongation_Homo sapiens_hsa000620.89937810
53Biosynthesis of amino acids_Homo sapiens_hsa012300.85973476
54Sulfur metabolism_Homo sapiens_hsa009200.83318873
55Collecting duct acid secretion_Homo sapiens_hsa049660.80967628
56Carbon metabolism_Homo sapiens_hsa012000.80448710
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78963869
58Fanconi anemia pathway_Homo sapiens_hsa034600.76325925
59Peroxisome_Homo sapiens_hsa041460.76097674
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75493255
61Legionellosis_Homo sapiens_hsa051340.75020153
62Caffeine metabolism_Homo sapiens_hsa002320.70085643
63Epstein-Barr virus infection_Homo sapiens_hsa051690.67916476
64mRNA surveillance pathway_Homo sapiens_hsa030150.64626477
65Metabolic pathways_Homo sapiens_hsa011000.64038716
66Vibrio cholerae infection_Homo sapiens_hsa051100.62412558
67p53 signaling pathway_Homo sapiens_hsa041150.61222089
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54454301
69Selenocompound metabolism_Homo sapiens_hsa004500.53393098
70Regulation of autophagy_Homo sapiens_hsa041400.48646632
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47537324
72Fatty acid metabolism_Homo sapiens_hsa012120.45302995
73Oocyte meiosis_Homo sapiens_hsa041140.44017167
74Propanoate metabolism_Homo sapiens_hsa006400.39971871
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39593138
76Chemical carcinogenesis_Homo sapiens_hsa052040.37718627
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36968966
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34391497
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34258228
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32790469
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31894432
82TGF-beta signaling pathway_Homo sapiens_hsa043500.31504805
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31223600
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.30701910
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24919043
86Steroid biosynthesis_Homo sapiens_hsa001000.24903113
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24868197
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.22651506
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22409896
90Linoleic acid metabolism_Homo sapiens_hsa005910.21777798
91Phototransduction_Homo sapiens_hsa047440.19932357
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19041397
93Phagosome_Homo sapiens_hsa041450.18515826
94Influenza A_Homo sapiens_hsa051640.17341199
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.17339771
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.17301381
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16397255
98Taste transduction_Homo sapiens_hsa047420.13899966
99Fatty acid degradation_Homo sapiens_hsa000710.13804936
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.12855490

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