ARMC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Armadillo/beta-catenin (CTNNB1; MIM 116806)-like (ARM) domains are imperfect 45-amino acid repeats involved in protein-protein interactions. ARM domain-containing proteins, such as ARMC3, function in signal transduction, development, cell adhesion and mobility, and tumor initiation and metastasis (Li et al., 2006 [PubMed 16915934]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.88863021
2sperm-egg recognition (GO:0035036)9.69200616
3acrosome assembly (GO:0001675)9.59564350
4cell wall macromolecule catabolic process (GO:0016998)9.48088215
5cell wall macromolecule metabolic process (GO:0044036)9.48088215
6plasma membrane fusion (GO:0045026)9.19362347
7binding of sperm to zona pellucida (GO:0007339)8.86297560
8cell-cell recognition (GO:0009988)8.70402517
9acrosome reaction (GO:0007340)8.67419950
10spermatid development (GO:0007286)8.28263734
11piRNA metabolic process (GO:0034587)8.18923232
12reproduction (GO:0000003)8.06595870
13ventricular system development (GO:0021591)7.99631798
14axoneme assembly (GO:0035082)7.79546651
15male meiosis (GO:0007140)7.34125393
16regulation of cilium movement (GO:0003352)7.24803038
17single fertilization (GO:0007338)7.02483959
18synaptonemal complex organization (GO:0070193)6.48927851
19GTP biosynthetic process (GO:0006183)6.04126720
20fertilization (GO:0009566)5.96362863
21negative regulation of inclusion body assembly (GO:0090084)5.90767199
22synaptonemal complex assembly (GO:0007130)5.85518190
23sperm capacitation (GO:0048240)5.74720768
24male meiosis I (GO:0007141)5.50041269
25nucleoside diphosphate phosphorylation (GO:0006165)5.47263570
26UTP biosynthetic process (GO:0006228)5.34689667
27left/right axis specification (GO:0070986)5.32574384
28spermatogenesis (GO:0007283)5.25586133
29male gamete generation (GO:0048232)5.23513045
30intraciliary transport (GO:0042073)5.18327105
31DNA methylation involved in gamete generation (GO:0043046)5.03382117
32UTP metabolic process (GO:0046051)4.97350962
33regulation of inclusion body assembly (GO:0090083)4.91735483
34gamete generation (GO:0007276)4.82904544
35protein localization to cilium (GO:0061512)4.73976263
36primary alcohol catabolic process (GO:0034310)4.67511349
37germ cell development (GO:0007281)4.61733651
38cilium organization (GO:0044782)4.59034746
39left/right pattern formation (GO:0060972)4.46388787
40cellular process involved in reproduction in multicellular organism (GO:0022412)4.45989822
41lung epithelium development (GO:0060428)4.41472682
42meiotic cell cycle (GO:0051321)4.41238113
43organic cation transport (GO:0015695)4.36869763
44meiosis I (GO:0007127)4.29462870
45CTP biosynthetic process (GO:0006241)4.28668781
46CTP metabolic process (GO:0046036)4.28668781
47chromosome organization involved in meiosis (GO:0070192)4.26147988
48meiotic nuclear division (GO:0007126)4.24193003
49cilium assembly (GO:0042384)4.24042076
50regulation of microtubule-based movement (GO:0060632)4.22559787
51seminiferous tubule development (GO:0072520)4.15549929
52guanosine-containing compound biosynthetic process (GO:1901070)4.14144614
53vitamin transmembrane transport (GO:0035461)4.11813888
54diterpenoid biosynthetic process (GO:0016102)4.11254527
55ethanol metabolic process (GO:0006067)4.05137953
56cell recognition (GO:0008037)4.01988635
57pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.89445471
58microtubule depolymerization (GO:0007019)3.86763788
59cilium morphogenesis (GO:0060271)3.84570058
60microtubule severing (GO:0051013)3.84015367
61spermatid nucleus differentiation (GO:0007289)3.81613204
62cellular component assembly involved in morphogenesis (GO:0010927)3.78904476
63multicellular organismal reproductive process (GO:0048609)3.78505736
64microtubule-based movement (GO:0007018)3.77815759
65pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.70519204
66one-carbon compound transport (GO:0019755)3.68395049
67glomerular epithelial cell development (GO:0072310)3.67981220
68smoothened signaling pathway (GO:0007224)3.66306437
69calcium ion-dependent exocytosis (GO:0017156)3.65238274
70microtubule polymerization or depolymerization (GO:0031109)3.63350462
71response to xenobiotic stimulus (GO:0009410)3.63209324
72determination of left/right symmetry (GO:0007368)3.57308043
73pyrimidine-containing compound transmembrane transport (GO:0072531)3.57232141
74tolerance induction (GO:0002507)3.56749134
75pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.55721102
76lateral ventricle development (GO:0021670)3.48962366
77negative regulation of T cell differentiation in thymus (GO:0033085)3.44274671
78determination of bilateral symmetry (GO:0009855)3.42901990
79negative regulation of immunoglobulin mediated immune response (GO:0002890)3.37083948
80negative regulation of B cell mediated immunity (GO:0002713)3.37083948
81specification of symmetry (GO:0009799)3.36381055
82protein refolding (GO:0042026)3.36107866
83chaperone-mediated protein complex assembly (GO:0051131)3.29716942
84microtubule bundle formation (GO:0001578)3.27581230
85establishment of planar polarity (GO:0001736)3.26145378
86establishment of tissue polarity (GO:0007164)3.26145378
87negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.22737508
88pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.21428911
89regulation of interleukin-5 production (GO:0032674)3.21202587
90cytoplasmic microtubule organization (GO:0031122)3.16228520
91genitalia morphogenesis (GO:0035112)3.15225765
92ethanol oxidation (GO:0006069)3.14196217
93phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.10015313
94regulation of interleukin-13 production (GO:0032656)3.08772743
95centriole assembly (GO:0098534)3.04947682
96centriole replication (GO:0007099)3.04243985
97protein polyglutamylation (GO:0018095)3.03501591
98negative regulation of humoral immune response (GO:0002921)3.01163524
99lateral sprouting from an epithelium (GO:0060601)2.98141126
100regulation of germinal center formation (GO:0002634)2.97135660
101positive regulation of smoothened signaling pathway (GO:0045880)2.96307116
102retinoic acid metabolic process (GO:0042573)2.95083086
103multicellular organismal development (GO:0007275)2.94336765
104establishment of apical/basal cell polarity (GO:0035089)2.92061666
105nonmotile primary cilium assembly (GO:0035058)2.91271436
106synapsis (GO:0007129)2.87802479
107nucleoside diphosphate metabolic process (GO:0009132)2.87101657
108terpenoid biosynthetic process (GO:0016114)2.87078254
109gene silencing by RNA (GO:0031047)2.83550564
110cell projection assembly (GO:0030031)2.81178649
111glutathione derivative biosynthetic process (GO:1901687)2.79141641
112glutathione derivative metabolic process (GO:1901685)2.79141641
113monoubiquitinated protein deubiquitination (GO:0035520)2.75855517
114retinal rod cell development (GO:0046548)2.71309598
115nucleotide phosphorylation (GO:0046939)2.70594471
116asymmetric protein localization (GO:0008105)2.69905549
117glycerol ether metabolic process (GO:0006662)2.69846191
118microtubule-based process (GO:0007017)2.69046815
119positive regulation of tolerance induction (GO:0002645)2.68215428
120photoreceptor cell maintenance (GO:0045494)2.67993566
121establishment of monopolar cell polarity (GO:0061162)2.67979525
122establishment or maintenance of monopolar cell polarity (GO:0061339)2.67979525
123regulation of meiosis I (GO:0060631)2.58238042
124regulation of secondary heart field cardioblast proliferation (GO:0003266)2.55267947
125regulation of cardioblast proliferation (GO:0003264)2.55267947
126retinol metabolic process (GO:0042572)2.54084403
127meiotic cell cycle process (GO:1903046)2.50808024
128regulation of response to osmotic stress (GO:0047484)2.50400765
129ether metabolic process (GO:0018904)2.48350853
130protein K11-linked deubiquitination (GO:0035871)2.47175338
131apical protein localization (GO:0045176)2.45724024
132amino-acid betaine transport (GO:0015838)2.42758722
133carnitine transport (GO:0015879)2.42758722
134carnitine transmembrane transport (GO:1902603)2.42479564
135neuron fate determination (GO:0048664)2.41390868
136spinal cord motor neuron differentiation (GO:0021522)2.41283730
137carnitine metabolic process (GO:0009437)2.40191361
138regulation of smoothened signaling pathway (GO:0008589)2.38408123
139renal system development (GO:0072001)2.38138880
140organelle assembly (GO:0070925)2.36164516
141exogenous drug catabolic process (GO:0042738)2.35351813
142pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.35336642
143regulation of collateral sprouting (GO:0048670)2.33506787
144negative regulation of skeletal muscle tissue development (GO:0048642)2.33288627
145neuronal stem cell maintenance (GO:0097150)2.31462402
146primary alcohol metabolic process (GO:0034308)2.30977985
147natural killer cell mediated immunity (GO:0002228)2.30360101
148natural killer cell mediated cytotoxicity (GO:0042267)2.30360101
149heart looping (GO:0001947)2.30194874
150embryonic heart tube morphogenesis (GO:0003143)2.30052668
151polyol catabolic process (GO:0046174)2.29957782
152neurotransmitter catabolic process (GO:0042135)2.27122486
153dorsal/ventral neural tube patterning (GO:0021904)2.26770538
154telencephalon development (GO:0021537)2.24603927
155photoreceptor cell differentiation (GO:0046530)2.23856539
156eye photoreceptor cell differentiation (GO:0001754)2.23856539
157hydrogen peroxide biosynthetic process (GO:0050665)2.23693709
158cilium or flagellum-dependent cell motility (GO:0001539)15.4741632
159axonemal dynein complex assembly (GO:0070286)13.8602915
160cilium movement (GO:0003341)12.6769563
161epithelial cilium movement (GO:0003351)12.2288217
162fusion of sperm to egg plasma membrane (GO:0007342)12.0860226
163sperm motility (GO:0030317)10.6908947
164motile cilium assembly (GO:0044458)10.3479082
165epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.0274113

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.72230059
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.22159525
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.07966942
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.70734417
5EZH2_22144423_ChIP-Seq_EOC_Human3.59335407
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.80553941
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.75851106
8DROSHA_22980978_ChIP-Seq_HELA_Human2.70819030
9PIAS1_25552417_ChIP-Seq_VCAP_Human2.39806985
10FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.37720551
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.35493602
12GBX2_23144817_ChIP-Seq_PC3_Human2.12450586
13EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.03778185
14GATA1_26923725_Chip-Seq_HPCs_Mouse1.90990338
15SCL_19346495_ChIP-Seq_HPC-7_Human1.86162390
16RBPJ_22232070_ChIP-Seq_NCS_Mouse1.85580313
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.82645817
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76734345
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76048258
20KAP1_22055183_ChIP-Seq_ESCs_Mouse1.71843701
21AHR_22903824_ChIP-Seq_MCF-7_Human1.71621455
22ARNT_22903824_ChIP-Seq_MCF-7_Human1.68571706
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.68016877
24TOP2B_26459242_ChIP-Seq_MCF-7_Human1.66440011
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.66393297
26* SMAD4_21799915_ChIP-Seq_A2780_Human1.66150617
27FOXM1_26456572_ChIP-Seq_MCF-7_Human1.64943318
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.63673867
29RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.63171297
30TAL1_26923725_Chip-Seq_HPCs_Mouse1.63008124
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62386735
32ELK4_26923725_Chip-Seq_MESODERM_Mouse1.61782340
33* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.61659925
34CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58765533
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58375160
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58303244
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56532651
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55530495
39STAT1_17558387_ChIP-Seq_HELA_Human1.54212659
40CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.52707374
41AR_21572438_ChIP-Seq_LNCaP_Human1.52321085
42TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.51882679
43TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.50125053
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.49346852
45SOX2_22085726_ChIP-Seq_NPCs_Mouse1.44493145
46* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43859557
47* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42843158
48ZNF274_21170338_ChIP-Seq_K562_Hela1.42316829
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40413411
50CBP_20019798_ChIP-Seq_JUKART_Human1.40413411
51TP53_18474530_ChIP-ChIP_U2OS_Human1.40211133
52* STAT3_23295773_ChIP-Seq_U87_Human1.37839708
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37486198
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.37420700
55* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37017889
56BCAT_22108803_ChIP-Seq_LS180_Human1.36914286
57FUS_26573619_Chip-Seq_HEK293_Human1.35736173
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34075897
59* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.33672891
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.33585810
61TAF15_26573619_Chip-Seq_HEK293_Human1.33555341
62GATA3_21867929_ChIP-Seq_CD8_Mouse1.32881398
63P300_19829295_ChIP-Seq_ESCs_Human1.31355701
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30845603
65TP63_23658742_ChIP-Seq_EP156T_Human1.30065956
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29616180
67WDR5_24793694_ChIP-Seq_LNCAP_Human1.28281873
68CRX_20693478_ChIP-Seq_RETINA_Mouse1.27460654
69KDM2B_26808549_Chip-Seq_REH_Human1.26506969
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26149996
71CTNNB1_20460455_ChIP-Seq_HCT116_Human1.25393096
72* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25169324
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24870058
74TCF4_22108803_ChIP-Seq_LS180_Human1.24832158
75VDR_22108803_ChIP-Seq_LS180_Human1.23417489
76IRF8_21731497_ChIP-ChIP_J774_Mouse1.22888129
77ETV1_20927104_ChIP-Seq_GIST48_Human1.22243184
78RNF2_27304074_Chip-Seq_NSC_Mouse1.21959521
79GATA3_21867929_ChIP-Seq_TH1_Mouse1.21692926
80GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.21399056
81ER_23166858_ChIP-Seq_MCF-7_Human1.21135870
82AR_25329375_ChIP-Seq_VCAP_Human1.20967474
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20129758
84* PHF8_20622853_ChIP-Seq_HELA_Human1.19763579
85IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18602333
86FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.18131107
87PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18020499
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.18012909
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17753404
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17733101
91TCF4_23295773_ChIP-Seq_U87_Human1.16617080
92SMRT_27268052_Chip-Seq_Bcells_Human1.16522180
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16092763
94ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15588310
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.14412429
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14208475
97P53_21459846_ChIP-Seq_SAOS-2_Human1.13474453
98EZH2_27294783_Chip-Seq_ESCs_Mouse1.13426679
99* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12201544
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11729514
101* HNFA_21074721_ChIP-Seq_CACO-2_Human1.11726448
102STAT1_20625510_ChIP-Seq_HELA_Human1.11459886
103PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.11049864
104TP53_16413492_ChIP-PET_HCT116_Human1.10292217
105* TBL1_22424771_ChIP-Seq_293T_Human1.09846840
106IRF8_27001747_Chip-Seq_BMDM_Mouse1.09476279
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08845390
108FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08300349
109GF1_26923725_Chip-Seq_HPCs_Mouse1.08214582
110ESR1_21235772_ChIP-Seq_MCF-7_Human1.07451121
111IRF8_22096565_ChIP-ChIP_GC-B_Human1.07199137
112RUNX2_22187159_ChIP-Seq_PCA_Human1.06846252
113ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06791889
114SMAD4_21741376_ChIP-Seq_EPCs_Human1.06646020
115NANOG_20526341_ChIP-Seq_ESCs_Human1.06573031
116ERG_20517297_ChIP-Seq_VCAP_Human1.06464607
117PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06364338
118OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06267676
119* OCT4_18555785_Chip-Seq_ESCs_Mouse1.05989807
120MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05439989
121CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05421957
122LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.04889154
123PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04347135
124* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.04258105
125SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.03836311
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02912315
127UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02528184
128PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02284597
129* NFYA_21822215_ChIP-Seq_K562_Human1.02205413
130RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02023386
131* STAT3_18555785_Chip-Seq_ESCs_Mouse1.01738891
132RBPJ_21746931_ChIP-Seq_IB4_Human1.01702681
133* P300_18555785_Chip-Seq_ESCs_Mouse1.01006123
134TRIM28_21343339_ChIP-Seq_HEK293_Human1.00986546
135CBX2_22325352_ChIP-Seq_293T-Rex_Human1.00836284
136* LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00319021
137MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00131823
138* NANOG_18555785_Chip-Seq_ESCs_Mouse1.00116369
139CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00015008
140* NFYB_21822215_ChIP-Seq_K562_Human0.99818458
141TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99804095
142SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99782936
143OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99750226
144PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99568202
145* P53_22387025_ChIP-Seq_ESCs_Mouse0.99490103
146GATA1_19941826_ChIP-Seq_K562_Human0.99270944
147ESRRB_18555785_Chip-Seq_ESCs_Mouse0.99233603
148NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99012565
149NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99012565
150SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98920900
151FOXA1_25552417_ChIP-Seq_VCAP_Human0.98728641
152RAD21_21589869_ChIP-Seq_MESCs_Mouse0.98525605
153FOXA1_25329375_ChIP-Seq_VCAP_Human0.98366881
154FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98366881
155BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98253417
156SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97527296
157EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96873578
158SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96316455
159* EWS_26573619_Chip-Seq_HEK293_Human0.95747582
160* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95503418
161POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95413601
162TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95413601
163GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94891570
164CDX2_20551321_ChIP-Seq_CACO-2_Human0.94629916
165AR_20517297_ChIP-Seq_VCAP_Human0.94576889
166NANOG_19829295_ChIP-Seq_ESCs_Human0.94292976
167SOX2_19829295_ChIP-Seq_ESCs_Human0.94292976
168SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94085897
169SOX2_21211035_ChIP-Seq_LN229_Gbm0.93914462
170SMAD4_21741376_ChIP-Seq_HESCs_Human0.93771003
171CMYC_18555785_Chip-Seq_ESCs_Mouse0.93711687
172AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93167961
173CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93127243
174* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91857841
175* KLF4_18555785_Chip-Seq_ESCs_Mouse0.91852906
176MYB_26560356_Chip-Seq_TH2_Human0.90757034
177EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90491008
178FLI1_21867929_ChIP-Seq_CD8_Mouse0.90283027
179* PU1_27457419_Chip-Seq_LIVER_Mouse0.88887437
180MYB_26560356_Chip-Seq_TH1_Human0.88325976

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.20058383
2MP0001929_abnormal_gametogenesis4.88285161
3MP0008875_abnormal_xenobiotic_pharmacok4.13090728
4MP0008877_abnormal_DNA_methylation3.90910733
5MP0002210_abnormal_sex_determination3.38632212
6MP0002653_abnormal_ependyma_morphology3.34218226
7MP0009780_abnormal_chondrocyte_physiolo3.06388050
8MP0000383_abnormal_hair_follicle2.77275615
9MP0001145_abnormal_male_reproductive2.76297557
10MP0002161_abnormal_fertility/fecundity2.72229375
11MP0002277_abnormal_respiratory_mucosa2.60849642
12MP0003136_yellow_coat_color2.56907880
13MP0000566_synostosis2.53970561
14MP0000653_abnormal_sex_gland2.43194135
15MP0005623_abnormal_meninges_morphology2.29273662
16MP0008789_abnormal_olfactory_epithelium2.25350819
17MP0004043_abnormal_pH_regulation2.16034675
18MP0010678_abnormal_skin_adnexa2.00565014
19MP0005410_abnormal_fertilization12.8998924
20MP0002160_abnormal_reproductive_system1.95284405
21MP0003283_abnormal_digestive_organ1.85767849
22MP0004808_abnormal_hematopoietic_stem1.75297308
23MP0001485_abnormal_pinna_reflex1.70171585
24MP0001835_abnormal_antigen_presentation1.67772518
25MP0002405_respiratory_system_inflammati1.67082180
26MP0004019_abnormal_vitamin_homeostasis1.58148462
27MP0002282_abnormal_trachea_morphology1.55651802
28MP0002132_abnormal_respiratory_system1.53564217
29MP0009785_altered_susceptibility_to1.52439539
30MP0000685_abnormal_immune_system1.50801910
31MP0000026_abnormal_inner_ear1.48033714
32MP0008995_early_reproductive_senescence1.41857623
33MP0005083_abnormal_biliary_tract1.40546574
34MP0001545_abnormal_hematopoietic_system1.39633279
35MP0005397_hematopoietic_system_phenotyp1.39633279
36MP0005499_abnormal_olfactory_system1.39120734
37MP0005394_taste/olfaction_phenotype1.39120734
38MP0002638_abnormal_pupillary_reflex1.38907251
39MP0001293_anophthalmia1.37581475
40MP0008057_abnormal_DNA_replication1.37516903
41MP0001984_abnormal_olfaction1.35216483
42MP0001851_eye_inflammation1.34559561
43MP0003880_abnormal_central_pattern1.33988940
44MP0008004_abnormal_stomach_pH1.33870410
45MP0002102_abnormal_ear_morphology1.33763092
46MP0003879_abnormal_hair_cell1.32701657
47MP0010030_abnormal_orbit_morphology1.31830965
48MP0005671_abnormal_response_to1.31268143
49MP0005171_absent_coat_pigmentation1.30634836
50MP0002233_abnormal_nose_morphology1.29496152
51MP0003011_delayed_dark_adaptation1.28371758
52MP0005389_reproductive_system_phenotype1.28263656
53MP0009053_abnormal_anal_canal1.27470597
54MP0003938_abnormal_ear_development1.26327751
55MP0002734_abnormal_mechanical_nocicepti1.26065065
56MP0002909_abnormal_adrenal_gland1.23566013
57MP0003763_abnormal_thymus_physiology1.22949093
58MP0005646_abnormal_pituitary_gland1.22813570
59MP0005084_abnormal_gallbladder_morpholo1.19456251
60MP0005647_abnormal_sex_gland1.18694349
61MP0005174_abnormal_tail_pigmentation1.18604966
62MP0006082_CNS_inflammation1.15521650
63MP0002928_abnormal_bile_duct1.12940283
64MP0000631_abnormal_neuroendocrine_gland1.12661284
65MP0008058_abnormal_DNA_repair1.08349961
66MP0001853_heart_inflammation1.04360769
67MP0005025_abnormal_response_to1.03017521
68MP0005075_abnormal_melanosome_morpholog1.02849927
69MP0000467_abnormal_esophagus_morphology1.00533476
70MP0002168_other_aberrant_phenotype1.00370036
71MP0005670_abnormal_white_adipose0.96614161
72MP0002723_abnormal_immune_serum0.95781989
73MP0005464_abnormal_platelet_physiology0.94274914
74MP0001346_abnormal_lacrimal_gland0.93733040
75MP0006276_abnormal_autonomic_nervous0.93045062
76MP0002735_abnormal_chemical_nociception0.90989130
77MP0001790_abnormal_immune_system0.90558765
78MP0005387_immune_system_phenotype0.90558765
79MP0002234_abnormal_pharynx_morphology0.90555052
80MP0001800_abnormal_humoral_immune0.90497194
81MP0003937_abnormal_limbs/digits/tail_de0.90493252
82MP0009046_muscle_twitch0.90279587
83MP0001970_abnormal_pain_threshold0.90094227
84MP0003646_muscle_fatigue0.89979102
85MP0003656_abnormal_erythrocyte_physiolo0.88763476
86MP0001324_abnormal_eye_pigmentation0.88618488
87MP0005248_abnormal_Harderian_gland0.88518893
88MP0002452_abnormal_antigen_presenting0.87971048
89MP0005187_abnormal_penis_morphology0.87345218
90MP0001963_abnormal_hearing_physiology0.87027318
91MP0002420_abnormal_adaptive_immunity0.86633588
92MP0001529_abnormal_vocalization0.85966949
93MP0003943_abnormal_hepatobiliary_system0.85147723
94MP0002419_abnormal_innate_immunity0.84228145
95MP0000372_irregular_coat_pigmentation0.84035183
96MP0001819_abnormal_immune_cell0.83876822
97MP0005000_abnormal_immune_tolerance0.83777394
98MP0000465_gastrointestinal_hemorrhage0.83439220
99MP0002148_abnormal_hypersensitivity_rea0.83255394
100MP0001873_stomach_inflammation0.82023324
101MP0009278_abnormal_bone_marrow0.81028952
102MP0004381_abnormal_hair_follicle0.79672600
103MP0002398_abnormal_bone_marrow0.79654900
104MP0000955_abnormal_spinal_cord0.79618169
105MP0001986_abnormal_taste_sensitivity0.79382204
106MP0001765_abnormal_ion_homeostasis0.79282723
107MP0003279_aneurysm0.78807594
108MP0004885_abnormal_endolymph0.77621156
109MP0010094_abnormal_chromosome_stability0.76448548
110MP0001486_abnormal_startle_reflex0.76147625
111MP0005195_abnormal_posterior_eye0.76020230
112MP0005408_hypopigmentation0.75467988
113MP0000049_abnormal_middle_ear0.74856162
114MP0002876_abnormal_thyroid_physiology0.72721700
115MP0008007_abnormal_cellular_replicative0.72719567
116MP0000716_abnormal_immune_system0.71689230
117MP0003786_premature_aging0.70851658
118MP0000534_abnormal_ureter_morphology0.69926944
119MP0003942_abnormal_urinary_system0.69708563
120MP0002822_catalepsy0.69466634
121MP0000689_abnormal_spleen_morphology0.68738448
122MP0003724_increased_susceptibility_to0.67650888
123MP0001879_abnormal_lymphatic_vessel0.67629182
124MP0008872_abnormal_physiological_respon0.67074677
125MP0000778_abnormal_nervous_system0.66603482
126MP0005395_other_phenotype0.66210902
127MP0009765_abnormal_xenobiotic_induced0.65166532
128MP0004133_heterotaxia0.65038894
129MP0001286_abnormal_eye_development0.63145599
130MP0002116_abnormal_craniofacial_bone0.61991063
131MP0005503_abnormal_tendon_morphology0.60997947
132MP0001845_abnormal_inflammatory_respons0.60749120
133MP0002572_abnormal_emotion/affect_behav0.60656985
134MP0002557_abnormal_social/conspecific_i0.59435057
135MP0002092_abnormal_eye_morphology0.59214403
136MP0005636_abnormal_mineral_homeostasis0.59026715
137MP0002133_abnormal_respiratory_system0.57094243
138MP0005388_respiratory_system_phenotype0.57094243
139MP0009745_abnormal_behavioral_response0.56945113
140MP0003638_abnormal_response/metabolism_0.56888113
141MP0002095_abnormal_skin_pigmentation0.56588745
142MP0002067_abnormal_sensory_capabilities0.56260550
143MP0001664_abnormal_digestion0.56145490
144MP0003119_abnormal_digestive_system0.55854889
145MP0002429_abnormal_blood_cell0.55773256
146MP0005377_hearing/vestibular/ear_phenot0.55596114
147MP0003878_abnormal_ear_physiology0.55596114
148MP0002722_abnormal_immune_system0.54970079
149MP0003075_altered_response_to0.54622623
150MP0002752_abnormal_somatic_nervous0.54377706
151MP0001968_abnormal_touch/_nociception0.53920751
152MP0003861_abnormal_nervous_system0.53671481
153MP0002736_abnormal_nociception_after0.53651511
154MP0000703_abnormal_thymus_morphology0.51923323
155MP0002396_abnormal_hematopoietic_system0.51739916
156MP0001919_abnormal_reproductive_system0.51519043
157MP0009115_abnormal_fat_cell0.51110853
158MP0003436_decreased_susceptibility_to0.50833372
159MP0009697_abnormal_copulation0.49919926
160MP0005409_darkened_coat_color0.49446545
161MP0001119_abnormal_female_reproductive0.49313259
162MP0003690_abnormal_glial_cell0.48992102
163MP0005391_vision/eye_phenotype0.48605096
164MP0001764_abnormal_homeostasis0.47690645
165MP0000358_abnormal_cell_content/0.44281796
166MP0005551_abnormal_eye_electrophysiolog0.44160765
167MP0001348_abnormal_lacrimal_gland0.44136778
168MP0008469_abnormal_protein_level0.43834007
169MP0005253_abnormal_eye_physiology0.43059190
170MP0002249_abnormal_larynx_morphology0.40990402
171MP0005167_abnormal_blood-brain_barrier0.40631914
172MP0003866_abnormal_defecation0.39729375
173MP0001440_abnormal_grooming_behavior0.39054955
174MP0004947_skin_inflammation0.36754377

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.36390689
2Abnormal ciliary motility (HP:0012262)9.24833804
3Abnormal respiratory epithelium morphology (HP:0012253)9.04443452
4Abnormal respiratory motile cilium morphology (HP:0005938)9.04443452
5Chronic bronchitis (HP:0004469)8.04610056
6Nasal polyposis (HP:0100582)6.67881133
7Abnormality of the nasal mucosa (HP:0000433)5.62752738
8Bronchiectasis (HP:0002110)5.55764596
9Bronchitis (HP:0012387)5.05177683
10Infertility (HP:0000789)4.78602676
11Recurrent sinusitis (HP:0011108)4.22905771
12Nephronophthisis (HP:0000090)4.08699192
13Recurrent otitis media (HP:0000403)3.50946749
14Tubulointerstitial nephritis (HP:0001970)3.19891420
15Chronic sinusitis (HP:0011109)3.17191770
16Abnormality of the renal medulla (HP:0100957)3.13237279
17Recurrent bronchitis (HP:0002837)3.05556101
18Pancreatic fibrosis (HP:0100732)3.01274540
19Molar tooth sign on MRI (HP:0002419)2.98272870
20Abnormality of midbrain morphology (HP:0002418)2.98272870
21True hermaphroditism (HP:0010459)2.94644217
22Atelectasis (HP:0100750)2.78102190
23Medial flaring of the eyebrow (HP:0010747)2.77873962
24Postaxial foot polydactyly (HP:0001830)2.65368814
25Tubular atrophy (HP:0000092)2.58659795
26Abnormal biliary tract physiology (HP:0012439)2.55900235
27Bile duct proliferation (HP:0001408)2.55900235
28Supernumerary spleens (HP:0009799)2.47794374
29Congenital hepatic fibrosis (HP:0002612)2.41505214
30Fibular hypoplasia (HP:0003038)2.32934890
31Cystic liver disease (HP:0006706)2.30978183
32Pancreatic cysts (HP:0001737)2.28485705
33Tubulointerstitial abnormality (HP:0001969)2.24810556
34Hyperactive renin-angiotensin system (HP:0000841)2.20886402
35Male infertility (HP:0003251)2.20756446
36Chronic hepatic failure (HP:0100626)2.16348516
37Gonadotropin excess (HP:0000837)2.15846111
38Median cleft lip (HP:0000161)2.08157130
39Abnormality of dentin (HP:0010299)2.08068784
40Aplasia/Hypoplasia of the tongue (HP:0010295)2.06836654
41Abnormal spermatogenesis (HP:0008669)2.05471986
42Abnormal drinking behavior (HP:0030082)2.02586476
43Polydipsia (HP:0001959)2.02586476
44Abnormality of the renal cortex (HP:0011035)2.01225234
45Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.2652452
46Absent/shortened dynein arms (HP:0200106)10.9871564
47Dynein arm defect of respiratory motile cilia (HP:0012255)10.9871564
48Abnormal respiratory motile cilium physiology (HP:0012261)10.8534452
49Stage 5 chronic kidney disease (HP:0003774)1.96897434
50Congenital primary aphakia (HP:0007707)1.90563104
51Gait imbalance (HP:0002141)1.88911008
5211 pairs of ribs (HP:0000878)1.88406637
53Occipital encephalocele (HP:0002085)1.87987816
54Abnormality of the dental root (HP:0006486)1.78604848
55Taurodontia (HP:0000679)1.78604848
56Abnormality of permanent molar morphology (HP:0011071)1.78604848
57Oculomotor apraxia (HP:0000657)1.77762015
58Postaxial hand polydactyly (HP:0001162)1.76114819
59Facial cleft (HP:0002006)1.75584348
60Nephrogenic diabetes insipidus (HP:0009806)1.69601465
61Renal dysplasia (HP:0000110)1.65574953
62Abnormality of molar (HP:0011077)1.65471750
63Abnormality of molar morphology (HP:0011070)1.65471750
64Anencephaly (HP:0002323)1.63670137
65Asplenia (HP:0001746)1.60320615
66Abnormality of the dental pulp (HP:0006479)1.57821273
67Aplasia/Hypoplasia of the spleen (HP:0010451)1.56603987
68Nephropathy (HP:0000112)1.54188356
69Chronic otitis media (HP:0000389)1.53816826
70Amyotrophic lateral sclerosis (HP:0007354)1.53363284
71Decreased circulating renin level (HP:0003351)1.48353753
72Azoospermia (HP:0000027)1.47861928
73Absent frontal sinuses (HP:0002688)1.47139190
74Tubulointerstitial fibrosis (HP:0005576)1.45510123
75Abdominal situs inversus (HP:0003363)1.40919640
76Abnormality of abdominal situs (HP:0011620)1.40919640
77Broad distal phalanx of finger (HP:0009836)1.39961411
78Preaxial hand polydactyly (HP:0001177)1.39245935
79Aplasia/Hypoplasia of the fibula (HP:0006492)1.38673885
80Male pseudohermaphroditism (HP:0000037)1.38180932
81Sclerocornea (HP:0000647)1.35039158
82Aplasia/Hypoplasia of the lens (HP:0008063)1.33362629
83Abnormality of renal excretion (HP:0011036)1.32862744
84Short ribs (HP:0000773)1.32690636
85Poor coordination (HP:0002370)1.32369551
86Genital tract atresia (HP:0001827)1.29339919
87Renal salt wasting (HP:0000127)1.29069702
88Hyperkalemia (HP:0002153)1.28964482
89Anophthalmia (HP:0000528)1.28914414
90Vaginal atresia (HP:0000148)1.23056919
91Dyschromatopsia (HP:0007641)1.22404934
92Polyuria (HP:0000103)1.19769565
93Short thorax (HP:0010306)1.19358148
94Cone-rod dystrophy (HP:0000548)1.18993251
95Abnormal urine output (HP:0012590)1.18663419
96Impaired proprioception (HP:0010831)1.18460144
97Microglossia (HP:0000171)1.18284241
98Narrow forehead (HP:0000341)1.17786033
99Impulsivity (HP:0100710)1.15703578
100Hyperaldosteronism (HP:0000859)1.15245979
101Large eyes (HP:0001090)1.14247889
102Prominent nasal bridge (HP:0000426)1.13570698
103Aganglionic megacolon (HP:0002251)1.13448935
104Bifid scrotum (HP:0000048)1.12444469
105Bell-shaped thorax (HP:0001591)1.11661656
106Abnormality of the lower motor neuron (HP:0002366)1.11352960
107Short nail (HP:0001799)1.10758174
108Holoprosencephaly (HP:0001360)1.10152500
109Intellectual disability, moderate (HP:0002342)1.10115962
110Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.09991674
111Abnormal rod and cone electroretinograms (HP:0008323)1.08967907
112Abnormality of macular pigmentation (HP:0008002)1.08774364
113Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.08049734
114Decreased central vision (HP:0007663)1.07366747
115Central scotoma (HP:0000603)1.07329109
116Retinitis pigmentosa (HP:0000510)1.07109832
117Abnormality of renin-angiotensin system (HP:0000847)1.06632238
118Constricted visual fields (HP:0001133)1.06485172
119Specific learning disability (HP:0001328)1.06280806
120J-shaped sella turcica (HP:0002680)1.06003415
121Absent rod-and cone-mediated responses on ERG (HP:0007688)1.05968483
122Upper motor neuron abnormality (HP:0002127)1.03549977
123Hypoplasia of the capital femoral epiphysis (HP:0003090)1.03149366
124Acute myeloid leukemia (HP:0004808)1.02378908
125Furrowed tongue (HP:0000221)1.01345381

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.83121247
2PDK47.83121247
3PDK25.40775792
4MAPK154.52559465
5PNCK4.31960006
6TESK13.36812621
7EPHA22.49070289
8PRKD32.33404118
9ICK2.32100140
10WEE12.21835613
11TSSK62.16952370
12PTK2B1.79011169
13STK241.63401990
14KIT1.47437525
15STK391.34528001
16MAP3K21.28355212
17WNK41.25420893
18TNIK1.24944868
19FRK1.22719985
20BMPR1B1.17216270
21MUSK1.16936959
22DYRK31.16390827
23IRAK11.16333166
24BCR1.15716162
25TEC1.14096670
26MAP4K11.12922845
27EPHA31.12900436
28EEF2K1.06885417
29VRK11.06131292
30NEK21.05509951
31ERBB20.97915508
32MAPKAPK50.96476573
33TGFBR10.96015906
34MAP3K40.95958855
35NME10.95190579
36BTK0.94699261
37DYRK1B0.92169314
38STK380.90624984
39LRRK20.88970457
40PLK20.87541155
41PDK10.86154049
42STK38L0.85207230
43MAP2K60.81185400
44TLK10.80536756
45TXK0.79636246
46ERBB30.78710822
47GRK10.77569847
48INSRR0.76309566
49NLK0.75221758
50MAPK130.74915825
51PASK0.74453041
52CSF1R0.73606178
53CCNB10.70862598
54STK100.70597442
55MAP3K70.67988129
56BMX0.65385473
57CASK0.64213932
58TGFBR20.63780504
59ADRBK20.63662949
60MAP2K70.63016861
61MYLK0.62508687
62ADRBK10.59907061
63ZAP700.57486095
64BRSK20.57455855
65ACVR1B0.56689009
66STK30.55633357
67MAP3K30.50441153
68BMPR20.50098363
69TIE10.49818983
70MARK20.49554761
71FLT30.48516849
72EPHB10.47319388
73PINK10.46445677
74ROCK10.46069475
75NTRK30.45429317
76RIPK40.45386729
77NTRK20.44653881
78SYK0.43747040
79WNK30.43649230
80IKBKE0.43066166
81CDK30.42402247
82CDC70.42160088
83RPS6KA40.41740067
84PAK20.41230218
85IRAK20.41020041
86FER0.40339147
87TBK10.40322686
88IRAK40.39869668
89PRKCI0.39553772
90MAP4K20.38868744
91WNK10.38610977
92NEK90.37566638
93MATK0.36900220
94AURKA0.35764398
95CLK10.35167580
96TESK20.34472958
97PRKCQ0.34173228
98JAK30.34172886
99LMTK20.33899573
100PRKD10.33738752
101DYRK1A0.33538341
102ILK0.33437231
103LATS10.33271865
104MST1R0.33192169
105ITK0.33141433
106NEK60.32943215
107EPHA40.32757433
108CAMKK10.31146695
109GRK60.31095327
110TTK0.30585371
111CSK0.30424858
112PRKACA0.29985707
113LCK0.29581078
114CAMK2A0.29318269
115MST40.28616963
116MAP2K40.28371514
117TRPM70.28168684
118PRKCD0.28009257
119GRK70.27923239
120CAMK2G0.27839582
121EPHB20.27704949
122FES0.27259735
123CDK80.27020806
124ATR0.26529539
125SGK20.26432489
126ROCK20.26257964
127SIK10.26241519
128HCK0.25692270
129RET0.25640739
130CAMK1G0.24691221
131LYN0.24486571
132PKN10.24129079
133PRKCE0.24123227
134RPS6KA50.23692720
135CDK190.23553347
136SGK10.23011403
137PIM20.22672749
138SGK4940.22376794
139SGK2230.22376794
140PRKG10.22369924
141OXSR10.22127487
142MAPKAPK30.22038458
143PRKCA0.22017151
144MAP3K120.21650292
145PIM10.21623056
146YES10.21224758
147CSNK1G20.20544946
148PRKG20.20466156
149CDK90.18245174
150CAMKK20.17776413
151CHEK20.17015853
152MAPK40.16445132
153MAP2K20.15519723
154TYK20.15326061
155ATM0.15106342
156PRKCG0.13931736
157CSNK2A10.11707903
158RPS6KA60.11556365
159STK160.11193813
160PAK10.11057196
161BLK0.10728535
162IKBKB0.10063209
163PDPK10.09538069
164RPS6KB10.09227492

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.25803412
2Phenylalanine metabolism_Homo sapiens_hsa003603.43026609
3Histidine metabolism_Homo sapiens_hsa003403.40478532
4Pyruvate metabolism_Homo sapiens_hsa006203.21577058
5Tyrosine metabolism_Homo sapiens_hsa003503.12269061
6Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.82323395
7Basal transcription factors_Homo sapiens_hsa030222.80341818
8beta-Alanine metabolism_Homo sapiens_hsa004102.40351515
9Antigen processing and presentation_Homo sapiens_hsa046122.38584444
10Fanconi anemia pathway_Homo sapiens_hsa034602.34597097
11Pentose phosphate pathway_Homo sapiens_hsa000302.27116441
12Huntingtons disease_Homo sapiens_hsa050162.23265389
13Glucagon signaling pathway_Homo sapiens_hsa049222.13549091
14Caffeine metabolism_Homo sapiens_hsa002321.97966996
15Propanoate metabolism_Homo sapiens_hsa006401.96657466
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.92684048
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.86368971
18B cell receptor signaling pathway_Homo sapiens_hsa046621.80529932
19Fatty acid biosynthesis_Homo sapiens_hsa000611.75499400
20Linoleic acid metabolism_Homo sapiens_hsa005911.73332229
21Purine metabolism_Homo sapiens_hsa002301.69040945
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.66603019
23Ether lipid metabolism_Homo sapiens_hsa005651.65525137
24Primary immunodeficiency_Homo sapiens_hsa053401.62975961
25Selenocompound metabolism_Homo sapiens_hsa004501.62359549
26Hedgehog signaling pathway_Homo sapiens_hsa043401.61402768
27Dorso-ventral axis formation_Homo sapiens_hsa043201.58781902
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.57726957
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.54093567
30Basal cell carcinoma_Homo sapiens_hsa052171.51850245
31Nitrogen metabolism_Homo sapiens_hsa009101.49513032
32Pyrimidine metabolism_Homo sapiens_hsa002401.41845870
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40742262
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.40263416
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37543905
36PPAR signaling pathway_Homo sapiens_hsa033201.36103482
37Glycerolipid metabolism_Homo sapiens_hsa005611.32661785
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30422940
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28565253
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.28019244
41Tight junction_Homo sapiens_hsa045301.26325881
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.25833342
43Salivary secretion_Homo sapiens_hsa049701.24513673
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.22560606
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22455863
46Phototransduction_Homo sapiens_hsa047441.21647720
47Measles_Homo sapiens_hsa051621.17564509
48Notch signaling pathway_Homo sapiens_hsa043301.16532442
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15977183
50Legionellosis_Homo sapiens_hsa051341.13810399
51Cocaine addiction_Homo sapiens_hsa050301.13544244
52Amphetamine addiction_Homo sapiens_hsa050311.12177623
53Nicotine addiction_Homo sapiens_hsa050331.09788835
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08849221
55Renin secretion_Homo sapiens_hsa049241.08729904
56Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08504519
57Chemical carcinogenesis_Homo sapiens_hsa052041.05970762
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03316272
59Peroxisome_Homo sapiens_hsa041461.02670751
60DNA replication_Homo sapiens_hsa030301.00623572
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.98768436
62Fatty acid degradation_Homo sapiens_hsa000710.97736706
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97625688
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.95872594
65Taste transduction_Homo sapiens_hsa047420.93893747
66Allograft rejection_Homo sapiens_hsa053300.93882898
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.93873257
68Herpes simplex infection_Homo sapiens_hsa051680.93064667
69Hematopoietic cell lineage_Homo sapiens_hsa046400.92191372
70Starch and sucrose metabolism_Homo sapiens_hsa005000.91710760
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90989215
72Mineral absorption_Homo sapiens_hsa049780.90488944
73ABC transporters_Homo sapiens_hsa020100.90337510
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90231053
75Arachidonic acid metabolism_Homo sapiens_hsa005900.89155289
76Oocyte meiosis_Homo sapiens_hsa041140.88986201
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88077171
78Osteoclast differentiation_Homo sapiens_hsa043800.86975423
79Salmonella infection_Homo sapiens_hsa051320.85788538
80T cell receptor signaling pathway_Homo sapiens_hsa046600.83524524
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82764890
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81815310
83Glutathione metabolism_Homo sapiens_hsa004800.81440753
84Serotonergic synapse_Homo sapiens_hsa047260.81410444
85N-Glycan biosynthesis_Homo sapiens_hsa005100.80509553
86Hippo signaling pathway_Homo sapiens_hsa043900.80138549
87Other glycan degradation_Homo sapiens_hsa005110.77773291
88Circadian rhythm_Homo sapiens_hsa047100.76238098
89Steroid biosynthesis_Homo sapiens_hsa001000.73867986
90Homologous recombination_Homo sapiens_hsa034400.72748931
91Systemic lupus erythematosus_Homo sapiens_hsa053220.72199458
92Choline metabolism in cancer_Homo sapiens_hsa052310.70313023
93Influenza A_Homo sapiens_hsa051640.69223083
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.67890097
95Tryptophan metabolism_Homo sapiens_hsa003800.67080792
96Butanoate metabolism_Homo sapiens_hsa006500.66237926
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.65925109
98Axon guidance_Homo sapiens_hsa043600.65130249
99Leishmaniasis_Homo sapiens_hsa051400.65009465
100Retinol metabolism_Homo sapiens_hsa008300.64708436
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64535976
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63093887
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62284544
104Collecting duct acid secretion_Homo sapiens_hsa049660.61896300
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58889556
106Gap junction_Homo sapiens_hsa045400.58494875
107Alcoholism_Homo sapiens_hsa050340.57206814
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.56559487
109ECM-receptor interaction_Homo sapiens_hsa045120.56204418
110Sphingolipid metabolism_Homo sapiens_hsa006000.55867867
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55836313
112Calcium signaling pathway_Homo sapiens_hsa040200.55254213
113Malaria_Homo sapiens_hsa051440.54508223
114Estrogen signaling pathway_Homo sapiens_hsa049150.53936398
115Circadian entrainment_Homo sapiens_hsa047130.52502002
116Fructose and mannose metabolism_Homo sapiens_hsa000510.51987069
117Pancreatic secretion_Homo sapiens_hsa049720.50934989
118Platelet activation_Homo sapiens_hsa046110.50375050
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50300628
120Toxoplasmosis_Homo sapiens_hsa051450.50007667
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49730117
122Adherens junction_Homo sapiens_hsa045200.48668340
123Gastric acid secretion_Homo sapiens_hsa049710.48156988
124Nucleotide excision repair_Homo sapiens_hsa034200.47582699
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46483424
126Asthma_Homo sapiens_hsa053100.45740602
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44757839
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44306555
129mRNA surveillance pathway_Homo sapiens_hsa030150.43816061
130Melanogenesis_Homo sapiens_hsa049160.42497092
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41565399
132Wnt signaling pathway_Homo sapiens_hsa043100.40954462
133Pertussis_Homo sapiens_hsa051330.40786626
134Arginine and proline metabolism_Homo sapiens_hsa003300.40129577
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.39621162
136Protein export_Homo sapiens_hsa030600.39372566
137Drug metabolism - other enzymes_Homo sapiens_hsa009830.39351114
138RNA transport_Homo sapiens_hsa030130.39038941
139cAMP signaling pathway_Homo sapiens_hsa040240.37922953
140Vascular smooth muscle contraction_Homo sapiens_hsa042700.37500852
141Glutamatergic synapse_Homo sapiens_hsa047240.37111105
142Cardiac muscle contraction_Homo sapiens_hsa042600.36215092
143RNA degradation_Homo sapiens_hsa030180.36120302
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.35628451
145Spliceosome_Homo sapiens_hsa030400.33926253
146Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33747979
147Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33501188
148cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32708531
149Leukocyte transendothelial migration_Homo sapiens_hsa046700.32025807
150Inositol phosphate metabolism_Homo sapiens_hsa005620.32001992
151Autoimmune thyroid disease_Homo sapiens_hsa053200.31042301
152Complement and coagulation cascades_Homo sapiens_hsa046100.31039532
153Olfactory transduction_Homo sapiens_hsa047400.31025019
154Viral carcinogenesis_Homo sapiens_hsa052030.30977849
155NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30791616
156Metabolic pathways_Homo sapiens_hsa011000.29703739
157Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28207133
158Rheumatoid arthritis_Homo sapiens_hsa053230.28180844
159Bile secretion_Homo sapiens_hsa049760.27644687
160Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.26557197
161Morphine addiction_Homo sapiens_hsa050320.25993382
162Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24592915
163GABAergic synapse_Homo sapiens_hsa047270.24568651
164Oxytocin signaling pathway_Homo sapiens_hsa049210.23762277

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