ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	* ventricular system development (GO:0021591)	8.35191143
2	fusion of sperm to egg plasma membrane (GO:0007342)	8.21783676
3	sperm motility (GO:0030317)	7.91995292
4	GTP biosynthetic process (GO:0006183)	7.71166034
5	nucleoside diphosphate phosphorylation (GO:0006165)	7.55568253
6	regulation of cilium movement (GO:0003352)	7.50141905
7	intraciliary transport (GO:0042073)	7.22434463
8	multicellular organism reproduction (GO:0032504)	7.14351053
9	acrosome assembly (GO:0001675)	6.87702553
10	UTP biosynthetic process (GO:0006228)	6.82298918
11	sperm-egg recognition (GO:0035036)	6.54224547
12	UTP metabolic process (GO:0046051)	6.34360281
13	cell wall macromolecule metabolic process (GO:0044036)	6.33844871
14	cell wall macromolecule catabolic process (GO:0016998)	6.33844871
15	spermatid development (GO:0007286)	6.20992458
16	plasma membrane fusion (GO:0045026)	6.18574512
17	negative regulation of inclusion body assembly (GO:0090084)	6.12601154
18	binding of sperm to zona pellucida (GO:0007339)	5.96354183
19	cilium organization (GO:0044782)	5.93937198
20	microtubule depolymerization (GO:0007019)	5.90047597
21	single fertilization (GO:0007338)	5.85039047
22	cell-cell recognition (GO:0009988)	5.79593691
23	acrosome reaction (GO:0007340)	5.74430382
24	reproduction (GO:0000003)	5.73849603
25	* left/right axis specification (GO:0070986)	5.63470187
26	cilium assembly (GO:0042384)	5.61669106
27	primary alcohol catabolic process (GO:0034310)	5.58195931
28	protein localization to cilium (GO:0061512)	5.55050262
29	microtubule polymerization or depolymerization (GO:0031109)	5.51469336
30	microtubule bundle formation (GO:0001578)	5.50516839
31	guanosine-containing compound biosynthetic process (GO:1901070)	5.48802768
32	cilium morphogenesis (GO:0060271)	5.40120218
33	male meiosis (GO:0007140)	5.35233001
34	piRNA metabolic process (GO:0034587)	5.26907309
35	CTP biosynthetic process (GO:0006241)	5.23406775
36	CTP metabolic process (GO:0046036)	5.23406775
37	microtubule severing (GO:0051013)	4.99352896
38	sensory perception of smell (GO:0007608)	4.94698798
39	cellular component assembly involved in morphogenesis (GO:0010927)	4.90285911
40	fertilization (GO:0009566)	4.83596120
41	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	4.74754841
42	synaptonemal complex organization (GO:0070193)	4.72776250
43	ethanol metabolic process (GO:0006067)	4.63114645
44	* microtubule-based movement (GO:0007018)	4.60653667
45	vitamin transmembrane transport (GO:0035461)	4.59057461
46	regulation of inclusion body assembly (GO:0090083)	4.54330498
47	diterpenoid biosynthetic process (GO:0016102)	4.53956407
48	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	4.51772367
49	glomerular epithelial cell development (GO:0072310)	4.49909848
50	regulation of microtubule-based movement (GO:0060632)	4.48246820
51	protein polyglutamylation (GO:0018095)	4.47514909
52	centriole assembly (GO:0098534)	4.45689322
53	establishment of apical/basal cell polarity (GO:0035089)	4.45252054
54	centriole replication (GO:0007099)	4.31883771
55	sperm capacitation (GO:0048240)	4.30809354
56	left/right pattern formation (GO:0060972)	4.19999326
57	nucleotide phosphorylation (GO:0046939)	4.10931966
58	spermatogenesis (GO:0007283)	4.10726937
59	male gamete generation (GO:0048232)	4.08514714
60	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	4.07067773
61	regulation of interleukin-5 production (GO:0032674)	3.99003080
62	establishment of monopolar cell polarity (GO:0061162)	3.94509762
63	establishment or maintenance of monopolar cell polarity (GO:0061339)	3.94509762
64	one-carbon compound transport (GO:0019755)	3.90400374
65	male meiosis I (GO:0007141)	3.87936672
66	response to xenobiotic stimulus (GO:0009410)	3.85411744
67	nucleoside diphosphate metabolic process (GO:0009132)	3.85259625
68	gamete generation (GO:0007276)	3.82647834
69	cell projection assembly (GO:0030031)	3.81820914
70	synaptonemal complex assembly (GO:0007130)	3.77002138
71	negative regulation of T cell differentiation in thymus (GO:0033085)	3.72311695
72	retinal rod cell development (GO:0046548)	3.67976091
73	regulation of interleukin-13 production (GO:0032656)	3.63579780
74	lung epithelium development (GO:0060428)	3.62506645
75	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.62343521
76	meiotic cell cycle (GO:0051321)	3.61768000
77	terpenoid biosynthetic process (GO:0016114)	3.48466989
78	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.44657622
79	germ cell development (GO:0007281)	3.42307252
80	ethanol oxidation (GO:0006069)	3.42298819
81	retinoic acid metabolic process (GO:0042573)	3.37556092
82	positive regulation of smoothened signaling pathway (GO:0045880)	3.34912402
83	protein refolding (GO:0042026)	3.32974751
84	establishment of tissue polarity (GO:0007164)	3.27631785
85	establishment of planar polarity (GO:0001736)	3.27631785
86	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.27159911
87	DNA methylation involved in gamete generation (GO:0043046)	3.26740805
88	cytoplasmic microtubule organization (GO:0031122)	3.23156304
89	calcium ion-dependent exocytosis (GO:0017156)	3.21165807
90	spermatid nucleus differentiation (GO:0007289)	3.11811980
91	photoreceptor cell maintenance (GO:0045494)	3.07655131
92	multicellular organismal reproductive process (GO:0048609)	3.06431231
93	meiosis I (GO:0007127)	3.04726330
94	sensory perception of chemical stimulus (GO:0007606)	3.03134262
95	cell recognition (GO:0008037)	2.91885964
96	aldehyde catabolic process (GO:0046185)	2.90560326
97	intra-S DNA damage checkpoint (GO:0031573)	2.89187837
98	lateral ventricle development (GO:0021670)	2.88114816
99	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.87244397
100	determination of left/right symmetry (GO:0007368)	2.85344564
101	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.82551494
102	organic cation transport (GO:0015695)	2.82239261
103	glutathione derivative biosynthetic process (GO:1901687)	2.81972750
104	glutathione derivative metabolic process (GO:1901685)	2.81972750
105	organelle assembly (GO:0070925)	2.80908778
106	smoothened signaling pathway (GO:0007224)	2.79345002
107	regulation of microtubule depolymerization (GO:0031114)	2.78207049
108	meiotic nuclear division (GO:0007126)	2.75384541
109	negative regulation of humoral immune response (GO:0002921)	2.74946113
110	negative regulation of immunoglobulin mediated immune response (GO:0002890)	2.74514441
111	negative regulation of B cell mediated immunity (GO:0002713)	2.74514441
112	determination of bilateral symmetry (GO:0009855)	2.73766977
113	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	2.72912928
114	brain morphogenesis (GO:0048854)	2.72363685
115	specification of symmetry (GO:0009799)	2.68640122
116	lateral sprouting from an epithelium (GO:0060601)	2.67767559
117	phosphatidylethanolamine metabolic process (GO:0046337)	2.59160234
118	heart looping (GO:0001947)	2.58205154
119	* microtubule-based process (GO:0007017)	2.57736363
120	pyrimidine ribonucleotide metabolic process (GO:0009218)	2.55590484
121	embryonic camera-type eye development (GO:0031076)	2.54892391
122	regulation of macrophage chemotaxis (GO:0010758)	2.49216346
123	exogenous drug catabolic process (GO:0042738)	2.47496196
124	regulation of smoothened signaling pathway (GO:0008589)	2.46213572
125	chromosome organization involved in meiosis (GO:0070192)	2.44310262
126	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.43531779
127	O-glycan processing (GO:0016266)	2.41155724
128	retinal cone cell development (GO:0046549)	2.40699764
129	regulation of mononuclear cell migration (GO:0071675)	2.40471929
130	nucleoside triphosphate biosynthetic process (GO:0009142)	2.40254038
131	C21-steroid hormone biosynthetic process (GO:0006700)	2.39806293
132	multicellular organismal aging (GO:0010259)	2.39798721
133	tolerance induction (GO:0002507)	2.39582310
134	CDP-diacylglycerol biosynthetic process (GO:0016024)	2.39511399
135	regulation of meiosis I (GO:0060631)	2.39381089
136	regulation of collateral sprouting (GO:0048670)	2.39279486
137	primary alcohol metabolic process (GO:0034308)	2.38533439
138	muscle organ morphogenesis (GO:0048644)	2.38188915
139	negative regulation of microtubule depolymerization (GO:0007026)	2.38115454
140	carnitine metabolic process (GO:0009437)	2.37565540
141	retinol metabolic process (GO:0042572)	2.37096530
142	embryonic heart tube morphogenesis (GO:0003143)	2.36536165
143	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.35575454
144	apical protein localization (GO:0045176)	2.34782006
145	chromosome condensation (GO:0030261)	2.34525598
146	nonmotile primary cilium assembly (GO:0035058)	2.34312115
147	cilium or flagellum-dependent cell motility (GO:0001539)	15.8156083
148	* cilium movement (GO:0003341)	15.1730978
149	* axonemal dynein complex assembly (GO:0070286)	13.6862985
150	epithelial cilium movement (GO:0003351)	13.4033660
151	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	11.4663887
152	axoneme assembly (GO:0035082)	11.1262103
153	motile cilium assembly (GO:0044458)	10.5834290

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	4.71248888
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.45275822
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.42535301
4	EZH2_22144423_ChIP-Seq_EOC_Human	4.03600657
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.74309161
6	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.79389077
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.64108569
8	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.55391726
9	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.46388153
10	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.28986039
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.28731082
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.11216045
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.08628449
14	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.04896565
15	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.98638033
16	VDR_22108803_ChIP-Seq_LS180_Human	1.95158171
17	* FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.94540816
18	TP53_18474530_ChIP-ChIP_U2OS_Human	1.92822571
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.87482448
20	RNF2_27304074_Chip-Seq_NSC_Mouse	1.86242701
21	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.81138613
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.81107241
23	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.79962133
24	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.78399040
25	ETV1_20927104_ChIP-Seq_GIST48_Human	1.76446154
26	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.76287162
27	* PHF8_20622853_ChIP-Seq_HELA_Human	1.76017504
28	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.74076642
29	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.72164529
30	* CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.66448918
31	* HNFA_21074721_ChIP-Seq_CACO-2_Human	1.64685306
32	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.64034632
33	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.62335925
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.60053520
35	RBPJ_21746931_ChIP-Seq_IB4_Human	1.59403728
36	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57810541
37	TP63_23658742_ChIP-Seq_EP156T_Human	1.57051199
38	AHR_22903824_ChIP-Seq_MCF-7_Human	1.54836241
39	* NFYB_21822215_ChIP-Seq_K562_Human	1.54779357
40	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.53128924
41	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.49728819
42	EWS_26573619_Chip-Seq_HEK293_Human	1.48340922
43	* NFYA_21822215_ChIP-Seq_K562_Human	1.46734027
44	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.46235380
45	* KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.46092184
46	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.44658544
47	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.44479495
48	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.43221258
49	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.40847948
50	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.39850912
51	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.38708372
52	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38708372
53	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.38659095
54	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.37830897
55	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.37238964
56	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.37056241
57	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.37053022
58	DROSHA_22980978_ChIP-Seq_HELA_Human	1.36820705
59	BCAT_22108803_ChIP-Seq_LS180_Human	1.34593501
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.32709111
61	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.30856126
62	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.30037334
63	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.29882011
64	REST_21632747_ChIP-Seq_MESCs_Mouse	1.28971106
65	STAT1_17558387_ChIP-Seq_HELA_Human	1.27924107
66	P300_19829295_ChIP-Seq_ESCs_Human	1.27654392
67	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.27593675
68	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.26975205
69	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26831318
70	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.26762055
71	* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26371135
72	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.26094729
73	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.26046873
74	P53_22387025_ChIP-Seq_ESCs_Mouse	1.25383977
75	AR_21572438_ChIP-Seq_LNCaP_Human	1.25260993
76	* GATA6_21074721_ChIP-Seq_CACO-2_Human	1.25145227
77	RUNX2_22187159_ChIP-Seq_PCA_Human	1.25048847
78	SMRT_27268052_Chip-Seq_Bcells_Human	1.24483515
79	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.23959618
80	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.23641207
81	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23573884
82	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23573884
83	STAT1_20625510_ChIP-Seq_HELA_Human	1.23182948
84	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.23142162
85	KDM2B_26808549_Chip-Seq_REH_Human	1.23012805
86	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.22835695
87	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22576176
88	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.22431728
89	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22396572
90	GF1_26923725_Chip-Seq_HPCs_Mouse	1.22342657
91	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.21652885
92	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.21579392
93	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.21273804
94	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20926332
95	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.20081544
96	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.19229640
97	CDX2_22108803_ChIP-Seq_LS180_Human	1.19207063
98	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.18757583
99	* SMAD4_21741376_ChIP-Seq_HESCs_Human	1.18607233
100	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.18564660
101	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.18154516
102	* GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.17800177
103	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.17727134
104	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.17608280
105	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.17552889
106	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.17233625
107	STAT3_23295773_ChIP-Seq_U87_Human	1.17201898
108	GBX2_23144817_ChIP-Seq_PC3_Human	1.16937093
109	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.16599815
110	* CBP_20019798_ChIP-Seq_JUKART_Human	1.16356964
111	* IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.16356964
112	* AR_25329375_ChIP-Seq_VCAP_Human	1.16265661
113	ZNF274_21170338_ChIP-Seq_K562_Hela	1.15780582
114	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15676141
115	TAF15_26573619_Chip-Seq_HEK293_Human	1.15391180
116	ER_23166858_ChIP-Seq_MCF-7_Human	1.14818079
117	* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.14463001
118	* CBP_21632823_ChIP-Seq_H3396_Human	1.14450591
119	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.14250091
120	* SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14146505
121	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.14143119
122	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.13881148
123	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.13627104
124	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.12931388
125	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.12930014
126	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.11576650
127	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.11288276
128	P300_18555785_Chip-Seq_ESCs_Mouse	1.11193572
129	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10625241
130	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.10375117
131	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09407636
132	TCF4_23295773_ChIP-Seq_U87_Human	1.09125431
133	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.09060492
134	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.08848856
135	ESRRB_18555785_Chip-Seq_ESCs_Mouse	1.08457725
136	FUS_26573619_Chip-Seq_HEK293_Human	1.08295747
137	ZFX_18555785_Chip-Seq_ESCs_Mouse	1.07593333
138	KLF4_18555785_Chip-Seq_ESCs_Mouse	1.07386006
139	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.06501166
140	LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.06074236
141	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.05498855
142	PU1_27457419_Chip-Seq_LIVER_Mouse	1.05302857
143	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.04927248
144	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03421421
145	AR_20517297_ChIP-Seq_VCAP_Human	1.03254502
146	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.02590972
147	* TBL1_22424771_ChIP-Seq_293T_Human	1.02330736
148	* ARNT_22903824_ChIP-Seq_MCF-7_Human	1.01889676
149	GF1B_26923725_Chip-Seq_HPCs_Mouse	1.01175892
150	ERG_20517297_ChIP-Seq_VCAP_Human	1.01129035
151	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.00358399
152	CEBPB_22108803_ChIP-Seq_LS180_Human	0.98002578
153	KLF5_25053715_ChIP-Seq_YYC3_Human	0.97563059
154	* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.96968623
155	NANOG_19829295_ChIP-Seq_ESCs_Human	0.96352371
156	SOX2_19829295_ChIP-Seq_ESCs_Human	0.96352371
157	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.96244703
158	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.95685683
159	GATA4_25053715_ChIP-Seq_YYC3_Human	0.93896038

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	8.98018384
2	MP0001984_abnormal_olfaction	6.76716135
3	MP0008004_abnormal_stomach_pH	5.87351430
4	MP0008875_abnormal_xenobiotic_pharmacok	4.43590631
5	MP0002653_abnormal_ependyma_morphology	4.38922640
6	MP0002132_abnormal_respiratory_system	4.05430307
7	MP0003698_abnormal_male_reproductive	3.83706644
8	MP0001929_abnormal_gametogenesis	3.50949602
9	MP0003136_yellow_coat_color	3.47755693
10	MP0005646_abnormal_pituitary_gland	3.00848901
11	MP0005623_abnormal_meninges_morphology	2.74031013
12	MP0002210_abnormal_sex_determination	2.62259303
13	MP0010030_abnormal_orbit_morphology	2.61743498
14	MP0002277_abnormal_respiratory_mucosa	2.43557790
15	MP0004043_abnormal_pH_regulation	2.38073560
16	MP0004133_heterotaxia	2.32549331
17	MP0002928_abnormal_bile_duct	2.21942604
18	MP0008877_abnormal_DNA_methylation	2.11545863
19	MP0002160_abnormal_reproductive_system	2.10684841
20	MP0002161_abnormal_fertility/fecundity	2.07204771
21	MP0000383_abnormal_hair_follicle	2.04660702
22	MP0001145_abnormal_male_reproductive	2.03611760
23	MP0001293_anophthalmia	1.99912267
24	MP0000566_synostosis	1.91623972
25	MP0001485_abnormal_pinna_reflex	1.91477981
26	MP0000653_abnormal_sex_gland	1.90191464
27	MP0005248_abnormal_Harderian_gland	1.85066539
28	MP0003890_abnormal_embryonic-extraembry	1.73272153
29	MP0010678_abnormal_skin_adnexa	1.70956290
30	MP0001440_abnormal_grooming_behavior	1.56407409
31	MP0003718_maternal_effect	1.53645366
32	MP0001346_abnormal_lacrimal_gland	1.52150190
33	MP0005647_abnormal_sex_gland	1.48643743
34	MP0005389_reproductive_system_phenotype	1.45136083
35	MP0005395_other_phenotype	1.42351183
36	MP0005503_abnormal_tendon_morphology	1.41878536
37	MP0009046_muscle_twitch	1.38605367
38	MP0002282_abnormal_trachea_morphology	1.37760375
39	MP0003011_delayed_dark_adaptation	1.32934448
40	MP0005551_abnormal_eye_electrophysiolog	1.30992792
41	MP0000678_abnormal_parathyroid_gland	1.29838165
42	MP0002102_abnormal_ear_morphology	1.28460189
43	MP0002084_abnormal_developmental_patter	1.23274036
44	MP0002734_abnormal_mechanical_nocicepti	1.17492762
45	MP0003119_abnormal_digestive_system	1.16687488
46	MP0002249_abnormal_larynx_morphology	1.14032698
47	MP0005377_hearing/vestibular/ear_phenot	1.12449254
48	MP0003878_abnormal_ear_physiology	1.12449254
49	MP0005379_endocrine/exocrine_gland_phen	1.11021320
50	MP0003941_abnormal_skin_development	1.08336482
51	MP0000631_abnormal_neuroendocrine_gland	1.07143145
52	MP0002638_abnormal_pupillary_reflex	1.06279607
53	MP0008995_early_reproductive_senescence	1.02171464
54	MP0001765_abnormal_ion_homeostasis	1.02126685
55	MP0000613_abnormal_salivary_gland	1.01627411
56	MP0001958_emphysema	1.00517552
57	MP0005083_abnormal_biliary_tract	0.99717900
58	MP0001299_abnormal_eye_distance/	0.97542043
59	MP0005408_hypopigmentation	0.95863251
60	MP0008789_abnormal_olfactory_epithelium	0.95710932
61	MP0002736_abnormal_nociception_after	0.94543751
62	MP0000049_abnormal_middle_ear	0.93857955
63	MP0002557_abnormal_social/conspecific_i	0.93482519
64	MP0004381_abnormal_hair_follicle	0.93189942
65	MP0009697_abnormal_copulation	0.93177928
66	MP0002133_abnormal_respiratory_system	0.90163468
67	MP0005388_respiratory_system_phenotype	0.90163468
68	MP0002085_abnormal_embryonic_tissue	0.89138862
69	MP0001851_eye_inflammation	0.88238816
70	MP0003879_abnormal_hair_cell	0.86963534
71	MP0009053_abnormal_anal_canal	0.85574748
72	MP0003937_abnormal_limbs/digits/tail_de	0.85105886
73	MP0004270_analgesia	0.84564502
74	MP0001968_abnormal_touch/_nociception	0.83393841
75	MP0001944_abnormal_pancreas_morphology	0.83093606
76	MP0002234_abnormal_pharynx_morphology	0.82835175
77	MP0005636_abnormal_mineral_homeostasis	0.82631040
78	MP0002111_abnormal_tail_morphology	0.82554679
79	MP0003634_abnormal_glial_cell	0.82438529
80	MP0002109_abnormal_limb_morphology	0.82303020
81	MP0003646_muscle_fatigue	0.82166194
82	MP0000778_abnormal_nervous_system	0.82072621
83	MP0001286_abnormal_eye_development	0.81737713
84	MP0006276_abnormal_autonomic_nervous	0.81355462
85	MP0001879_abnormal_lymphatic_vessel	0.81212472
86	MP0003938_abnormal_ear_development	0.80149092
87	MP0000470_abnormal_stomach_morphology	0.79350047
88	MP0000534_abnormal_ureter_morphology	0.78747965
89	MP0004019_abnormal_vitamin_homeostasis	0.78038998
90	MP0003943_abnormal_hepatobiliary_system	0.77567867
91	MP0004145_abnormal_muscle_electrophysio	0.77423683
92	MP0010368_abnormal_lymphatic_system	0.77014269
93	MP0010386_abnormal_urinary_bladder	0.76553741
94	MP0005394_taste/olfaction_phenotype	0.74781783
95	MP0005499_abnormal_olfactory_system	0.74781783
96	MP0000516_abnormal_urinary_system	0.74764051
97	MP0005367_renal/urinary_system_phenotyp	0.74764051
98	MP0002752_abnormal_somatic_nervous	0.74577063
99	MP0001324_abnormal_eye_pigmentation	0.74440575
100	MP0004782_abnormal_surfactant_physiolog	0.74150675
101	MP0005391_vision/eye_phenotype	0.73931440
102	MP0005253_abnormal_eye_physiology	0.73804595
103	MP0006072_abnormal_retinal_apoptosis	0.73003397
104	MP0009703_decreased_birth_body	0.72195619
105	MP0000026_abnormal_inner_ear	0.72180492
106	MP0002152_abnormal_brain_morphology	0.71367733
107	MP0002272_abnormal_nervous_system	0.71093558
108	MP0000432_abnormal_head_morphology	0.68480268
109	MP0003935_abnormal_craniofacial_develop	0.68184284
110	MP0009780_abnormal_chondrocyte_physiolo	0.67711791
111	MP0003252_abnormal_bile_duct	0.67624496
112	MP0003755_abnormal_palate_morphology	0.67468971
113	MP0001486_abnormal_startle_reflex	0.66142906
114	MP0004742_abnormal_vestibular_system	0.66060618
115	MP0002168_other_aberrant_phenotype	0.65352496
116	MP0002572_abnormal_emotion/affect_behav	0.65011259
117	MP0004957_abnormal_blastocyst_morpholog	0.64855131
118	MP0002233_abnormal_nose_morphology	0.64754198
119	MP0003861_abnormal_nervous_system	0.64245609
120	MP0001919_abnormal_reproductive_system	0.62572119
121	MP0000681_abnormal_thyroid_gland	0.62434291
122	MP0002909_abnormal_adrenal_gland	0.62181012
123	MP0002932_abnormal_joint_morphology	0.61595370
124	MP0000358_abnormal_cell_content/	0.60713555
125	MP0001963_abnormal_hearing_physiology	0.60627224
126	MP0000462_abnormal_digestive_system	0.60215272
127	MP0002184_abnormal_innervation	0.59888945
128	MP0002693_abnormal_pancreas_physiology	0.59516659
129	MP0003950_abnormal_plasma_membrane	0.59426706
130	MP0000762_abnormal_tongue_morphology	0.59391204
131	MP0003656_abnormal_erythrocyte_physiolo	0.58941945
132	MP0001501_abnormal_sleep_pattern	0.58815301
133	MP0002092_abnormal_eye_morphology	0.56468398
134	MP0003942_abnormal_urinary_system	0.56286815
135	MP0002116_abnormal_craniofacial_bone	0.56029332
136	MP0001849_ear_inflammation	0.55497494
137	MP0010094_abnormal_chromosome_stability	0.55203228
138	MP0002882_abnormal_neuron_morphology	0.54999173
139	MP0000955_abnormal_spinal_cord	0.54991378
140	MP0005645_abnormal_hypothalamus_physiol	0.54562316
141	MP0001119_abnormal_female_reproductive	0.53995033
142	MP0006292_abnormal_olfactory_placode	0.52670661
143	MP0005195_abnormal_posterior_eye	0.52121101
144	MP0000428_abnormal_craniofacial_morphol	0.51571801
145	MP0002971_abnormal_brown_adipose	0.51002336
146	MP0002295_abnormal_pulmonary_circulatio	0.50797755
147	MP0005670_abnormal_white_adipose	0.50166172
148	MP0001177_atelectasis	0.50002278
149	MP0008058_abnormal_DNA_repair	0.49469398
150	MP0001270_distended_abdomen	0.48935435
151	MP0002735_abnormal_chemical_nociception	0.47537643

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dynein arm defect of respiratory motile cilia (HP:0012255)	9.85409607
2	Absent/shortened dynein arms (HP:0200106)	9.85409607
3	Abnormal respiratory motile cilium morphology (HP:0005938)	9.53886648
4	Abnormal respiratory epithelium morphology (HP:0012253)	9.53886648
5	* Rhinitis (HP:0012384)	9.10004677
6	* Chronic bronchitis (HP:0004469)	6.46062091
7	Nasal polyposis (HP:0100582)	5.19338711
8	* Bronchiectasis (HP:0002110)	5.18902965
9	Pancreatic fibrosis (HP:0100732)	4.45219004
10	Abnormality of the nasal mucosa (HP:0000433)	4.23861534
11	True hermaphroditism (HP:0010459)	4.13927542
12	Infertility (HP:0000789)	4.08338191
13	Nephronophthisis (HP:0000090)	4.04442342
14	Abnormality of midbrain morphology (HP:0002418)	3.97546948
15	Molar tooth sign on MRI (HP:0002419)	3.97546948
16	Tubulointerstitial nephritis (HP:0001970)	3.91365856
17	Recurrent sinusitis (HP:0011108)	3.82144459
18	Pancreatic cysts (HP:0001737)	3.36390357
19	Abnormality of dentin (HP:0010299)	3.35441549
20	Occipital encephalocele (HP:0002085)	3.30832778
21	Cystic liver disease (HP:0006706)	3.28033579
22	* Bronchitis (HP:0012387)	3.23924572
23	Medial flaring of the eyebrow (HP:0010747)	3.23721439
24	Chronic hepatic failure (HP:0100626)	3.20116420
25	Male infertility (HP:0003251)	3.16901657
26	Abnormality of the renal medulla (HP:0100957)	3.10809241
27	Abnormal biliary tract physiology (HP:0012439)	3.09656038
28	Bile duct proliferation (HP:0001408)	3.09656038
29	Supernumerary spleens (HP:0009799)	3.02618010
30	Postaxial foot polydactyly (HP:0001830)	2.94187273
31	Median cleft lip (HP:0000161)	2.91588480
32	Congenital hepatic fibrosis (HP:0002612)	2.86847097
33	Chronic sinusitis (HP:0011109)	2.86310855
34	Gait imbalance (HP:0002141)	2.75280564
35	Congenital primary aphakia (HP:0007707)	2.74233374
36	Abnormality of the dental root (HP:0006486)	2.69151196
37	Taurodontia (HP:0000679)	2.69151196
38	Abnormality of permanent molar morphology (HP:0011071)	2.69151196
39	Tubular atrophy (HP:0000092)	2.66415592
40	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.61420975
41	Abnormality of molar morphology (HP:0011070)	2.56028591
42	Abnormality of molar (HP:0011077)	2.56028591
43	Abnormality of the dental pulp (HP:0006479)	2.54393259
44	Tubulointerstitial abnormality (HP:0001969)	2.44165252
45	Nephrogenic diabetes insipidus (HP:0009806)	2.43327961
46	* Recurrent otitis media (HP:0000403)	2.37911129
47	Hyperactive renin-angiotensin system (HP:0000841)	2.35778224
48	Postaxial hand polydactyly (HP:0001162)	2.26765749
49	Anencephaly (HP:0002323)	2.26708571
50	Chronic otitis media (HP:0000389)	2.20619136
51	Genital tract atresia (HP:0001827)	2.19063227
52	Stage 5 chronic kidney disease (HP:0003774)	2.16297388
53	Male pseudohermaphroditism (HP:0000037)	2.13853121
54	Facial cleft (HP:0002006)	2.12972553
55	Oculomotor apraxia (HP:0000657)	2.11123724
56	Vaginal atresia (HP:0000148)	2.09387208
57	Poor coordination (HP:0002370)	2.01928591
58	* Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	12.5423050
59	* Abnormal respiratory motile cilium physiology (HP:0012261)	11.1818472
60	Abnormal ciliary motility (HP:0012262)	10.8065443
61	Bifid tongue (HP:0010297)	1.99327759
62	Sclerocornea (HP:0000647)	1.97444653
63	Fibular hypoplasia (HP:0003038)	1.96949969
64	Abnormal drinking behavior (HP:0030082)	1.96861705
65	Polydipsia (HP:0001959)	1.96861705
66	Preaxial hand polydactyly (HP:0001177)	1.95847512
67	Broad distal phalanx of finger (HP:0009836)	1.93215464
68	Abnormality of the renal cortex (HP:0011035)	1.91405089
69	Furrowed tongue (HP:0000221)	1.83542267
70	Aplasia/Hypoplasia of the lens (HP:0008063)	1.76599471
71	Asplenia (HP:0001746)	1.76516237
72	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.75475920
73	Absent frontal sinuses (HP:0002688)	1.65986710
74	Abnormality of macular pigmentation (HP:0008002)	1.62231408
75	Nephropathy (HP:0000112)	1.61641150
76	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.60776416
77	Short nail (HP:0001799)	1.56069803
78	Retinal dysplasia (HP:0007973)	1.53821401
79	Hyperkalemia (HP:0002153)	1.50369566
80	Cone-rod dystrophy (HP:0000548)	1.49760737
81	Abnormality of renal excretion (HP:0011036)	1.47338142
82	Abdominal situs inversus (HP:0003363)	1.43167148
83	Abnormality of abdominal situs (HP:0011620)	1.43167148
84	Renal salt wasting (HP:0000127)	1.42504164
85	Hypotelorism (HP:0000601)	1.42122806
86	Bony spicule pigmentary retinopathy (HP:0007737)	1.40893250
87	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.39888769
88	Atelectasis (HP:0100750)	1.38794767
89	Tubulointerstitial fibrosis (HP:0005576)	1.35262290
90	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.33417614
91	Back pain (HP:0003418)	1.32554437
92	Polycystic kidney dysplasia (HP:0000113)	1.31813237
93	Abnormal rod and cone electroretinograms (HP:0008323)	1.31445313
94	Recurrent bronchitis (HP:0002837)	1.30642060
95	Decreased central vision (HP:0007663)	1.29355971
96	Short ribs (HP:0000773)	1.29218464
97	Dyschromatopsia (HP:0007641)	1.28759359
98	Short thorax (HP:0010306)	1.27627138
99	Retinitis pigmentosa (HP:0000510)	1.26821998
100	Decreased circulating renin level (HP:0003351)	1.25516106
101	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.24970934
102	Aganglionic megacolon (HP:0002251)	1.22945149
103	Central scotoma (HP:0000603)	1.22204945
104	Renal dysplasia (HP:0000110)	1.22136993
105	Abnormal urine output (HP:0012590)	1.20125187
106	Anophthalmia (HP:0000528)	1.19951689
107	Broad foot (HP:0001769)	1.18881351
108	Constricted visual fields (HP:0001133)	1.18180472
109	Polyuria (HP:0000103)	1.17229735
110	Prominent nasal bridge (HP:0000426)	1.17224935
111	Bell-shaped thorax (HP:0001591)	1.17101282
112	Hypodontia (HP:0000668)	1.17052816
113	Abnormality of the hepatic vasculature (HP:0006707)	1.14800390
114	Severe visual impairment (HP:0001141)	1.14786823
115	Polycystic ovaries (HP:0000147)	1.14354128
116	Narrow forehead (HP:0000341)	1.14353826
117	Hyperaldosteronism (HP:0000859)	1.13098310
118	Ectopic anus (HP:0004397)	1.12575074
119	Abnormality of the distal phalanges of the toes (HP:0010182)	1.12528107
120	Multicystic kidney dysplasia (HP:0000003)	1.11690414
121	Holoprosencephaly (HP:0001360)	1.11144982
122	Portal hypertension (HP:0001409)	1.10560009
123	Intellectual disability, moderate (HP:0002342)	1.08344995
124	Optic nerve coloboma (HP:0000588)	1.08105261
125	Glucose intolerance (HP:0000833)	1.07535389
126	Bifid scrotum (HP:0000048)	1.05777810

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	7.87491616
2	PNCK	6.45499513
3	PDK4	5.44319771
4	PDK3	5.44319771
5	PDK2	3.41341154
6	EPHA2	3.15056220
7	PRKD3	3.01535434
8	PLK4	2.86117017
9	GRK1	2.43251899
10	TESK1	2.30790787
11	STK39	2.13103674
12	PBK	2.01687250
13	WNK4	2.00187841
14	PTK2B	1.85467109
15	FRK	1.79801383
16	INSRR	1.79772190
17	MST1R	1.75319473
18	STK38L	1.72140007
19	BCR	1.69224835
20	NME1	1.68198810
21	ACVR1B	1.67331465
22	WEE1	1.57677710
23	BRSK2	1.48354095
24	VRK1	1.46899420
25	ERBB4	1.42251189
26	MST4	1.39994273
27	ICK	1.39201848
28	MKNK2	1.33546601
29	MUSK	1.32800707
30	TSSK6	1.31693368
31	STK38	1.28240888
32	PLK1	1.16009937
33	MAPKAPK5	1.10896711
34	PLK2	1.05761936
35	MET	1.05464687
36	IRAK1	1.05099709
37	BRD4	1.03389303
38	TNIK	0.98559999
39	MAP4K2	0.98285534
40	CDK3	0.96380717
41	ERBB3	0.96191793
42	LATS1	0.95970729
43	MAP2K7	0.95756757
44	MKNK1	0.95222382
45	LMTK2	0.92447869
46	TRIM28	0.91080050
47	BMPR2	0.88763231
48	PRKCG	0.82430540
49	ZAK	0.81400106
50	SMG1	0.79682079
51	LRRK2	0.78490133
52	BUB1	0.76204362
53	STK24	0.74922845
54	WNK1	0.74412861
55	OXSR1	0.71145936
56	MAP3K2	0.69238315
57	NEK6	0.68304100
58	NTRK2	0.67704885
59	MYLK	0.66666721
60	BMPR1B	0.66556089
61	MAPKAPK3	0.66316144
62	RPS6KA2	0.65919650
63	PLK3	0.65241312
64	MAP2K2	0.65051054
65	NEK1	0.64422061
66	IRAK2	0.64056280
67	DYRK1B	0.63950209
68	PAK2	0.63652235
69	EEF2K	0.63420574
70	CDK19	0.62940000
71	SIK1	0.62776770
72	CAMK1G	0.61941049
73	STK10	0.61258248
74	CAMK2D	0.60538472
75	VRK2	0.60470919
76	DYRK3	0.60308625
77	NEK9	0.60202616
78	CDC42BPA	0.59915775
79	EIF2AK1	0.59650439
80	CDK8	0.59083888
81	PRKCI	0.56395056
82	CAMK2B	0.56349470
83	SRPK1	0.54534970
84	PAK3	0.54103120
85	PHKG2	0.52577416
86	PHKG1	0.52577416
87	MAP3K12	0.52362418
88	FER	0.52091626
89	TLK1	0.50797035
90	ADRBK1	0.49709598
91	AURKB	0.49351041
92	CAMK2G	0.48907188
93	PRKG2	0.48478249
94	TTK	0.47941092
95	STK3	0.46948857
96	PDK1	0.46849788
97	CDC7	0.45372538
98	HIPK2	0.45234670
99	MAP3K7	0.44880293
100	CDK9	0.44641376
101	PASK	0.42120667
102	CHEK2	0.41378854
103	TGFBR1	0.41040090
104	PRKCQ	0.40760453
105	CAMK2A	0.40589427
106	CHEK1	0.40034719
107	ATR	0.39181242
108	CCNB1	0.39152646
109	PRKD2	0.36613308
110	GSK3A	0.35745342
111	PINK1	0.35325538
112	ERBB2	0.32796872
113	MAPK13	0.31928563
114	AKT3	0.31802343
115	NLK	0.31296527
116	PRKCE	0.31183206
117	TRPM7	0.30724550
118	AKT2	0.29914182
119	BRSK1	0.28362021
120	AURKA	0.28274196
121	PRKG1	0.28263515
122	ADRBK2	0.27367728
123	MAP3K4	0.26988553
124	TEC	0.26646380
125	PRKACA	0.26560744
126	PRKAA1	0.26017541
127	PKN1	0.25542642
128	PRKAA2	0.25095343
129	DMPK	0.24509462
130	TYRO3	0.23277468
131	NEK2	0.22815422
132	WNK3	0.22384272
133	CDK1	0.22204726
134	CDK7	0.21846240
135	PAK4	0.21730535
136	MELK	0.21555471
137	CSNK1A1L	0.21242959
138	ATM	0.21159130
139	PRKACG	0.20781542
140	PRKDC	0.20734804
141	ROCK2	0.19642968
142	CSNK1G1	0.19439630
143	GRK5	0.19348002
144	BRAF	0.18187386
145	ROCK1	0.17988897
146	PIK3CG	0.17884414
147	DYRK1A	0.17195289
148	CASK	0.16779427
149	DAPK2	0.16532318
150	TRIB3	0.16102829
151	MAPKAPK2	0.16076385
152	CAMKK1	0.15931986
153	STK16	0.15729089
154	NUAK1	0.15717628
155	CSNK1E	0.14775802
156	TNK2	0.13710011
157	PDPK1	0.13675728
158	PRKCA	0.13508410

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Olfactory transduction_Homo sapiens_hsa04740	6.01861562
2	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.58395588
3	Phenylalanine metabolism_Homo sapiens_hsa00360	3.53263101
4	Tyrosine metabolism_Homo sapiens_hsa00350	2.93979690
5	beta-Alanine metabolism_Homo sapiens_hsa00410	2.67755252
6	Huntingtons disease_Homo sapiens_hsa05016	2.59867107
7	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	2.21802745
8	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.13799240
9	Insulin secretion_Homo sapiens_hsa04911	2.01846302
10	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.99735031
11	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.95277356
12	Amphetamine addiction_Homo sapiens_hsa05031	1.85637088
13	Pyruvate metabolism_Homo sapiens_hsa00620	1.85132810
14	Gastric acid secretion_Homo sapiens_hsa04971	1.84951197
15	Propanoate metabolism_Homo sapiens_hsa00640	1.79245077
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.68212648
17	Glucagon signaling pathway_Homo sapiens_hsa04922	1.63554632
18	Phototransduction_Homo sapiens_hsa04744	1.62058980
19	Estrogen signaling pathway_Homo sapiens_hsa04915	1.60345636
20	Caffeine metabolism_Homo sapiens_hsa00232	1.59500846
21	Non-homologous end-joining_Homo sapiens_hsa03450	1.56459078
22	PPAR signaling pathway_Homo sapiens_hsa03320	1.55032405
23	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.51027159
24	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.46804060
25	Basal cell carcinoma_Homo sapiens_hsa05217	1.44346461
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.43660215
27	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.43454470
28	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.39097145
29	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.35346819
30	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.35332828
31	cAMP signaling pathway_Homo sapiens_hsa04024	1.33584036
32	Purine metabolism_Homo sapiens_hsa00230	1.33266736
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.32494557
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.32389124
35	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.29983817
36	Mismatch repair_Homo sapiens_hsa03430	1.29237785
37	Butanoate metabolism_Homo sapiens_hsa00650	1.28968183
38	Mineral absorption_Homo sapiens_hsa04978	1.28271845
39	Circadian entrainment_Homo sapiens_hsa04713	1.27034343
40	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.26027871
41	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.24569413
42	Taste transduction_Homo sapiens_hsa04742	1.23844293
43	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.20721432
44	Thyroid hormone synthesis_Homo sapiens_hsa04918	1.20399785
45	Ether lipid metabolism_Homo sapiens_hsa00565	1.20249082
46	Protein export_Homo sapiens_hsa03060	1.17678603
47	Sphingolipid metabolism_Homo sapiens_hsa00600	1.17392663
48	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.14583019
49	Renin secretion_Homo sapiens_hsa04924	1.13472491
50	Cocaine addiction_Homo sapiens_hsa05030	1.09347384
51	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.09118968
52	Fanconi anemia pathway_Homo sapiens_hsa03460	1.08233003
53	Glycerolipid metabolism_Homo sapiens_hsa00561	1.08057887
54	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.07880573
55	Calcium signaling pathway_Homo sapiens_hsa04020	1.04638005
56	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.02566654
57	Hippo signaling pathway_Homo sapiens_hsa04390	1.00558112
58	Retinol metabolism_Homo sapiens_hsa00830	0.98773391
59	Salivary secretion_Homo sapiens_hsa04970	0.97313662
60	Basal transcription factors_Homo sapiens_hsa03022	0.95679694
61	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.95066644
62	Glutamatergic synapse_Homo sapiens_hsa04724	0.95047158
63	Homologous recombination_Homo sapiens_hsa03440	0.93982211
64	Morphine addiction_Homo sapiens_hsa05032	0.93976040
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.93395291
66	Base excision repair_Homo sapiens_hsa03410	0.92398136
67	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.90889251
68	Oocyte meiosis_Homo sapiens_hsa04114	0.90561664
69	Vibrio cholerae infection_Homo sapiens_hsa05110	0.89721990
70	Bile secretion_Homo sapiens_hsa04976	0.89515385
71	Pyrimidine metabolism_Homo sapiens_hsa00240	0.88313918
72	RNA polymerase_Homo sapiens_hsa03020	0.87074832
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.84436944
74	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.83993425
75	Histidine metabolism_Homo sapiens_hsa00340	0.83885522
76	Adherens junction_Homo sapiens_hsa04520	0.81700633
77	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.79988619
78	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.79119314
79	RNA transport_Homo sapiens_hsa03013	0.78064466
80	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.77465606
81	Glutathione metabolism_Homo sapiens_hsa00480	0.75617616
82	Sulfur metabolism_Homo sapiens_hsa00920	0.75513153
83	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.74611667
84	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.73769639
85	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.73510515
86	Selenocompound metabolism_Homo sapiens_hsa00450	0.73273338
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.72758915
88	GABAergic synapse_Homo sapiens_hsa04727	0.72630129
89	Dopaminergic synapse_Homo sapiens_hsa04728	0.71548331
90	Collecting duct acid secretion_Homo sapiens_hsa04966	0.71547624
91	Chemical carcinogenesis_Homo sapiens_hsa05204	0.68394028
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.67489813
93	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.67241166
94	Pancreatic secretion_Homo sapiens_hsa04972	0.66808606
95	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.66460222
96	Circadian rhythm_Homo sapiens_hsa04710	0.65720097
97	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.65162464
98	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.64524056
99	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.63320739
100	Cell cycle_Homo sapiens_hsa04110	0.63103875
101	p53 signaling pathway_Homo sapiens_hsa04115	0.63086717
102	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.62105427
103	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.61855747
104	Cardiac muscle contraction_Homo sapiens_hsa04260	0.61840352
105	Tryptophan metabolism_Homo sapiens_hsa00380	0.61223827
106	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.61054034
107	DNA replication_Homo sapiens_hsa03030	0.60887936
108	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.59584831
109	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.58949935
110	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.58849383
111	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.57708484
112	Nitrogen metabolism_Homo sapiens_hsa00910	0.57104534
113	GnRH signaling pathway_Homo sapiens_hsa04912	0.55164587
114	Cholinergic synapse_Homo sapiens_hsa04725	0.54684718
115	Antigen processing and presentation_Homo sapiens_hsa04612	0.52114739
116	Melanogenesis_Homo sapiens_hsa04916	0.51605465
117	One carbon pool by folate_Homo sapiens_hsa00670	0.51274687
118	Wnt signaling pathway_Homo sapiens_hsa04310	0.50138245
119	Pentose phosphate pathway_Homo sapiens_hsa00030	0.49121894
120	Fatty acid degradation_Homo sapiens_hsa00071	0.48053617
121	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.46405393
122	Fatty acid metabolism_Homo sapiens_hsa01212	0.46332158
123	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.45835312
124	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.45579513
125	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.44942280
126	Spliceosome_Homo sapiens_hsa03040	0.44737352
127	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.44247313
128	Alcoholism_Homo sapiens_hsa05034	0.44023309
129	ABC transporters_Homo sapiens_hsa02010	0.42528756
130	Long-term potentiation_Homo sapiens_hsa04720	0.41926433
131	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40715420
132	Peroxisome_Homo sapiens_hsa04146	0.40490444
133	Steroid biosynthesis_Homo sapiens_hsa00100	0.39720797
134	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.39304611
135	Tight junction_Homo sapiens_hsa04530	0.38794051
136	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.37665294
137	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.36708542
138	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.36220604
139	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.36184336
140	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.35500578
141	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.35467992
142	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.34309162
143	Protein digestion and absorption_Homo sapiens_hsa04974	0.34139955
144	Nicotine addiction_Homo sapiens_hsa05033	0.34009010
145	Metabolic pathways_Homo sapiens_hsa01100	0.33581998
146	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.33492215
147	Gap junction_Homo sapiens_hsa04540	0.31891749
148	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.31519468
149	RNA degradation_Homo sapiens_hsa03018	0.28013743
150	mRNA surveillance pathway_Homo sapiens_hsa03015	0.27105326
151	Oxidative phosphorylation_Homo sapiens_hsa00190	0.26175937
152	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.22305216
153	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.21789621

ARMC4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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