ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	6.78670188
2	cellular ketone body metabolic process (GO:0046950)	5.64981887
3	negative regulation of cytosolic calcium ion concentration (GO:0051481)	5.57507443
4	ketone body metabolic process (GO:1902224)	4.95212620
5	protein localization to Golgi apparatus (GO:0034067)	4.94420608
6	protein targeting to Golgi (GO:0000042)	4.92091706
7	establishment of protein localization to Golgi (GO:0072600)	4.84819631
8	sperm motility (GO:0030317)	4.49662807
9	acrosome reaction (GO:0007340)	4.44418125
10	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.43725128
11	ventricular system development (GO:0021591)	4.43082866
12	regulation of cilium movement (GO:0003352)	4.42425207
13	axonemal dynein complex assembly (GO:0070286)	4.34346328
14	neuron cell-cell adhesion (GO:0007158)	4.26365476
15	single strand break repair (GO:0000012)	4.25398116
16	epithelial cell fate commitment (GO:0072148)	4.18595531
17	epithelial cilium movement (GO:0003351)	4.17838901
18	protein polyglutamylation (GO:0018095)	4.17810581
19	photoreceptor cell differentiation (GO:0046530)	4.07648986
20	eye photoreceptor cell differentiation (GO:0001754)	4.07648986
21	cilium movement (GO:0003341)	3.95566766
22	protein K11-linked deubiquitination (GO:0035871)	3.89847670
23	spermatid development (GO:0007286)	3.89787984
24	regulation of transmission of nerve impulse (GO:0051969)	3.81012707
25	auditory behavior (GO:0031223)	3.74373087
26	locomotory exploration behavior (GO:0035641)	3.73919503
27	alanine transport (GO:0032328)	3.61742673
28	intraciliary transport (GO:0042073)	3.56832331
29	mechanosensory behavior (GO:0007638)	3.53615480
30	cochlea development (GO:0090102)	3.52796978
31	nonmotile primary cilium assembly (GO:0035058)	3.48436004
32	C4-dicarboxylate transport (GO:0015740)	3.45342444
33	peristalsis (GO:0030432)	3.44407129
34	regulation of type B pancreatic cell apoptotic process (GO:2000674)	3.39202460
35	fusion of sperm to egg plasma membrane (GO:0007342)	3.34217390
36	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.29680023
37	positive regulation of glycolytic process (GO:0045821)	3.29413398
38	microtubule severing (GO:0051013)	3.26678167
39	lactate metabolic process (GO:0006089)	3.25259243
40	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.22059009
41	multicellular organism reproduction (GO:0032504)	3.18915538
42	presynaptic membrane assembly (GO:0097105)	3.17294318
43	cilium organization (GO:0044782)	3.17131210
44	RNA destabilization (GO:0050779)	3.14690573
45	astrocyte differentiation (GO:0048708)	3.12887791
46	cell wall macromolecule metabolic process (GO:0044036)	3.12754978
47	cilium assembly (GO:0042384)	3.12342487
48	calcium ion-dependent exocytosis (GO:0017156)	3.08812931
49	sperm-egg recognition (GO:0035036)	3.07883883
50	cilium or flagellum-dependent cell motility (GO:0001539)	3.07099443
51	startle response (GO:0001964)	3.05087888
52	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.99762685
53	proline transport (GO:0015824)	2.99727968
54	cullin deneddylation (GO:0010388)	2.94332154
55	fucose catabolic process (GO:0019317)	2.92828068
56	L-fucose metabolic process (GO:0042354)	2.92828068
57	L-fucose catabolic process (GO:0042355)	2.92828068
58	cilium morphogenesis (GO:0060271)	2.90142732
59	snRNA transcription (GO:0009301)	2.89065799
60	ribonucleoprotein complex disassembly (GO:0032988)	2.87826230
61	metanephric tubule development (GO:0072170)	2.87531842
62	metanephric nephron tubule development (GO:0072234)	2.87531842
63	microtubule depolymerization (GO:0007019)	2.86703151
64	Golgi to endosome transport (GO:0006895)	2.85737129
65	detection of calcium ion (GO:0005513)	2.84517869
66	motile cilium assembly (GO:0044458)	2.83596396
67	positive regulation of meiosis (GO:0045836)	2.82632568
68	inner mitochondrial membrane organization (GO:0007007)	2.82558005
69	toxin metabolic process (GO:0009404)	2.81930300
70	cell wall macromolecule catabolic process (GO:0016998)	2.81066439
71	spermatid nucleus differentiation (GO:0007289)	2.80572232
72	signal peptide processing (GO:0006465)	2.79297664
73	phosphatidylethanolamine metabolic process (GO:0046337)	2.76100900
74	L-alpha-amino acid transmembrane transport (GO:1902475)	2.75454620
75	inositol metabolic process (GO:0006020)	2.74969504
76	transmission of nerve impulse (GO:0019226)	2.74930549
77	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.73886584
78	dorsal/ventral axis specification (GO:0009950)	2.73843138
79	intra-Golgi vesicle-mediated transport (GO:0006891)	2.71278980
80	seminiferous tubule development (GO:0072520)	2.70919680
81	sperm capacitation (GO:0048240)	2.68721738
82	neurotransmitter-gated ion channel clustering (GO:0072578)	2.68292794
83	dendritic spine morphogenesis (GO:0060997)	2.68183830
84	cell-cell recognition (GO:0009988)	2.68091165
85	postsynaptic membrane organization (GO:0001941)	2.66367751
86	histone H3-K9 demethylation (GO:0033169)	2.66212857
87	vesicle transport along microtubule (GO:0047496)	2.65209847
88	spinal cord motor neuron differentiation (GO:0021522)	2.63992102
89	peptidyl-cysteine modification (GO:0018198)	2.63358083
90	regulation of axon regeneration (GO:0048679)	2.62988741
91	regulation of neuron projection regeneration (GO:0070570)	2.62988741
92	binding of sperm to zona pellucida (GO:0007339)	2.62977215
93	positive regulation of meiotic cell cycle (GO:0051446)	2.62399327
94	single fertilization (GO:0007338)	2.61269985
95	somite rostral/caudal axis specification (GO:0032525)	2.60433630
96	plasma membrane fusion (GO:0045026)	2.60038864
97	neuronal action potential (GO:0019228)	2.59987316
98	renal tubule development (GO:0061326)	2.59708036
99	spermatogenesis (GO:0007283)	2.58498743
100	reproduction (GO:0000003)	2.58040841

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.36151594
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.24854422
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.23210885
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.09984675
5	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.85477709
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.79906482
7	FUS_26573619_Chip-Seq_HEK293_Human	2.74021484
8	VDR_22108803_ChIP-Seq_LS180_Human	2.54507362
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.47540682
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.44710857
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.44527897
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.41058235
13	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.29045757
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.26239206
15	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.22668406
16	CBP_20019798_ChIP-Seq_JUKART_Human	2.22668406
17	P300_19829295_ChIP-Seq_ESCs_Human	2.12360102
18	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.10381671
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.92237853
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.90049450
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.85875980
22	SMAD4_21799915_ChIP-Seq_A2780_Human	1.80308269
23	AR_25329375_ChIP-Seq_VCAP_Human	1.76779910
24	EZH2_22144423_ChIP-Seq_EOC_Human	1.73942768
25	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.68527709
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.67848249
27	EWS_26573619_Chip-Seq_HEK293_Human	1.66656356
28	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.66408071
29	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.64595929
30	STAT3_23295773_ChIP-Seq_U87_Human	1.63586100
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63477663
32	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.61614115
33	BCAT_22108803_ChIP-Seq_LS180_Human	1.59356669
34	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.57425320
35	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.55935231
36	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.54342594
37	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.47873465
38	TCF4_23295773_ChIP-Seq_U87_Human	1.44281147
39	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.41201297
40	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.40945768
41	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.40582122
42	RUNX2_22187159_ChIP-Seq_PCA_Human	1.40557113
43	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.40163573
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39551144
45	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.38752092
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.34725185
47	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.34619524
48	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.33073454
49	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.32673443
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31425847
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31425847
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31269865
53	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.31262940
54	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30768004
55	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.30768004
56	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.30195926
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.30140094
58	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28262796
59	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28231764
60	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.27251605
61	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.27044780
62	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.26213222
63	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.25984728
64	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.21970056
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20205115
66	CDX2_22108803_ChIP-Seq_LS180_Human	1.18921840
67	KDM2B_26808549_Chip-Seq_REH_Human	1.18886844
68	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.18280928
69	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.18197834
70	TP53_22573176_ChIP-Seq_HFKS_Human	1.17970236
71	RNF2_27304074_Chip-Seq_NSC_Mouse	1.17747607
72	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.15949402
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13446718
74	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13446718
75	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.12461440
76	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.11822199
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.11734953
78	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10306880
79	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.08700518
80	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.07313598
81	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.07112839
82	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.06474372
83	REST_21632747_ChIP-Seq_MESCs_Mouse	1.04519069
84	TBL1_22424771_ChIP-Seq_293T_Human	1.02957242
85	CBP_21632823_ChIP-Seq_H3396_Human	1.00667095
86	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00592250
87	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.00233797
88	NCOR_22424771_ChIP-Seq_293T_Human	0.99317109
89	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.98774852
90	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98592607
91	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.96755209
92	NFYB_21822215_ChIP-Seq_K562_Human	0.96292257
93	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.96285912
94	IRF1_19129219_ChIP-ChIP_H3396_Human	0.96098115
95	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.95819951
96	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.95384160
97	MYC_19829295_ChIP-Seq_ESCs_Human	0.95326091
98	JUN_21703547_ChIP-Seq_K562_Human	0.94960914
99	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.94865079
100	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94549671

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005379_endocrine/exocrine_gland_phen	3.67976193
2	MP0005410_abnormal_fertilization	3.34365551
3	MP0002837_dystrophic_cardiac_calcinosis	3.04141391
4	MP0002163_abnormal_gland_morphology	2.97109897
5	MP0003122_maternal_imprinting	2.83791957
6	MP0003787_abnormal_imprinting	2.71667578
7	MP0002638_abnormal_pupillary_reflex	2.40258866
8	MP0005645_abnormal_hypothalamus_physiol	2.28999684
9	MP0001984_abnormal_olfaction	2.27806506
10	MP0006072_abnormal_retinal_apoptosis	2.27793947
11	MP0009046_muscle_twitch	2.20989390
12	MP0001986_abnormal_taste_sensitivity	2.16746926
13	MP0002909_abnormal_adrenal_gland	2.15394904
14	MP0000013_abnormal_adipose_tissue	2.13616081
15	MP0001529_abnormal_vocalization	2.09891667
16	MP0003121_genomic_imprinting	2.06088863
17	MP0000427_abnormal_hair_cycle	2.04160855
18	MP0008877_abnormal_DNA_methylation	1.98284674
19	MP0010234_abnormal_vibrissa_follicle	1.96741126
20	MP0010678_abnormal_skin_adnexa	1.83171312
21	MP0001501_abnormal_sleep_pattern	1.72945589
22	MP0000383_abnormal_hair_follicle	1.72854036
23	MP0006276_abnormal_autonomic_nervous	1.70627553
24	MP0006292_abnormal_olfactory_placode	1.70235514
25	MP0008995_early_reproductive_senescence	1.68487527
26	MP0003698_abnormal_male_reproductive	1.66199521
27	MP0001929_abnormal_gametogenesis	1.65531794
28	MP0002272_abnormal_nervous_system	1.64172401
29	MP0005253_abnormal_eye_physiology	1.58388012
30	MP0009745_abnormal_behavioral_response	1.54214027
31	MP0002736_abnormal_nociception_after	1.52298286
32	MP0002735_abnormal_chemical_nociception	1.50964751
33	MP0004885_abnormal_endolymph	1.50578562
34	MP0004270_analgesia	1.49789917
35	MP0004859_abnormal_synaptic_plasticity	1.49311180
36	MP0003718_maternal_effect	1.48664753
37	MP0001485_abnormal_pinna_reflex	1.47217624
38	MP0001968_abnormal_touch/_nociception	1.46179376
39	MP0000516_abnormal_urinary_system	1.42958817
40	MP0005367_renal/urinary_system_phenotyp	1.42958817
41	MP0005551_abnormal_eye_electrophysiolog	1.40668913
42	MP0001764_abnormal_homeostasis	1.39258471
43	MP0000631_abnormal_neuroendocrine_gland	1.36172530
44	MP0004782_abnormal_surfactant_physiolog	1.34954807
45	MP0001486_abnormal_startle_reflex	1.34476566
46	MP0002693_abnormal_pancreas_physiology	1.32641242
47	MP0002064_seizures	1.29955250
48	MP0003283_abnormal_digestive_organ	1.29312531
49	MP0001944_abnormal_pancreas_morphology	1.25039634
50	MP0002557_abnormal_social/conspecific_i	1.22649965
51	MP0003011_delayed_dark_adaptation	1.20694290
52	MP0003635_abnormal_synaptic_transmissio	1.19701470
53	MP0002234_abnormal_pharynx_morphology	1.16995207
54	MP0005646_abnormal_pituitary_gland	1.15522990
55	MP0002572_abnormal_emotion/affect_behav	1.12983313
56	MP0004085_abnormal_heartbeat	1.10991370
57	MP0005535_abnormal_body_temperature	1.09679309
58	MP0008961_abnormal_basal_metabolism	1.09640052
59	MP0000647_abnormal_sebaceous_gland	1.07402445
60	MP0003786_premature_aging	1.06833734
61	MP0004742_abnormal_vestibular_system	1.05790850
62	MP0002210_abnormal_sex_determination	1.01838817
63	MP0001440_abnormal_grooming_behavior	1.00443007
64	MP0003195_calcinosis	1.00062686
65	MP0003880_abnormal_central_pattern	0.97998044
66	MP0002184_abnormal_innervation	0.97750249
67	MP0004134_abnormal_chest_morphology	0.97684111
68	MP0002127_abnormal_cardiovascular_syste	0.97294417
69	MP0001765_abnormal_ion_homeostasis	0.94963411
70	MP0000653_abnormal_sex_gland	0.94394613
71	MP0002078_abnormal_glucose_homeostasis	0.92567815
72	MP0008789_abnormal_olfactory_epithelium	0.91970744
73	MP0000026_abnormal_inner_ear	0.91771460
74	MP0003878_abnormal_ear_physiology	0.91427942
75	MP0005377_hearing/vestibular/ear_phenot	0.91427942
76	MP0008058_abnormal_DNA_repair	0.91305970
77	MP0005408_hypopigmentation	0.91181587
78	MP0001970_abnormal_pain_threshold	0.89442871
79	MP0001963_abnormal_hearing_physiology	0.89398772
80	MP0002733_abnormal_thermal_nociception	0.87853581
81	MP0002160_abnormal_reproductive_system	0.87392415
82	MP0003633_abnormal_nervous_system	0.87357091
83	MP0005085_abnormal_gallbladder_physiolo	0.87233758
84	MP0005220_abnormal_exocrine_pancreas	0.87192778
85	MP0004215_abnormal_myocardial_fiber	0.86306536
86	MP0005423_abnormal_somatic_nervous	0.86302450
87	MP0004133_heterotaxia	0.85230899
88	MP0000955_abnormal_spinal_cord	0.84806850
89	MP0001145_abnormal_male_reproductive	0.82861490
90	MP0005084_abnormal_gallbladder_morpholo	0.81601034
91	MP0002067_abnormal_sensory_capabilities	0.80466450
92	MP0002229_neurodegeneration	0.80400836
93	MP0002063_abnormal_learning/memory/cond	0.80322240
94	MP0005386_behavior/neurological_phenoty	0.79904969
95	MP0004924_abnormal_behavior	0.79904969
96	MP0002161_abnormal_fertility/fecundity	0.79184070
97	MP0005394_taste/olfaction_phenotype	0.77855370
98	MP0005499_abnormal_olfactory_system	0.77855370
99	MP0000003_abnormal_adipose_tissue	0.77723610
100	MP0004019_abnormal_vitamin_homeostasis	0.77516196

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperinsulinemic hypoglycemia (HP:0000825)	4.91309097
2	Hypoglycemic seizures (HP:0002173)	4.46966927
3	Medial flaring of the eyebrow (HP:0010747)	4.13897144
4	Hepatoblastoma (HP:0002884)	4.11115315
5	Hypoglycemic coma (HP:0001325)	3.69724681
6	Pancreatic fibrosis (HP:0100732)	3.64871508
7	Chronic hepatic failure (HP:0100626)	3.63126227
8	Ketoacidosis (HP:0001993)	3.62393543
9	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.60832054
10	Pancreatic cysts (HP:0001737)	3.52909858
11	Abnormality of endocrine pancreas physiology (HP:0012093)	3.49928456
12	Abnormality of the pancreatic islet cells (HP:0006476)	3.49928456
13	Gaze-evoked nystagmus (HP:0000640)	3.31446283
14	Ketosis (HP:0001946)	3.21526967
15	True hermaphroditism (HP:0010459)	3.21300189
16	Hypomagnesemia (HP:0002917)	3.18999935
17	Attenuation of retinal blood vessels (HP:0007843)	3.17793538
18	Gait imbalance (HP:0002141)	3.16828534
19	Nephronophthisis (HP:0000090)	3.15774601
20	Congenital primary aphakia (HP:0007707)	3.15688454
21	Occipital encephalocele (HP:0002085)	3.13989847
22	Abnormal rod and cone electroretinograms (HP:0008323)	3.11653347
23	Late onset (HP:0003584)	3.11480632
24	Gout (HP:0001997)	3.05177620
25	Renal Fanconi syndrome (HP:0001994)	3.05151241
26	Abnormal drinking behavior (HP:0030082)	2.93192646
27	Polydipsia (HP:0001959)	2.93192646
28	Abnormality of the renal cortex (HP:0011035)	2.92738260
29	Hyperglycemia (HP:0003074)	2.82775105
30	Symptomatic seizures (HP:0011145)	2.80067628
31	Abnormal respiratory motile cilium physiology (HP:0012261)	2.73446986
32	Bony spicule pigmentary retinopathy (HP:0007737)	2.72893760
33	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.71851786
34	Absent/shortened dynein arms (HP:0200106)	2.71851786
35	Abnormality of midbrain morphology (HP:0002418)	2.70022509
36	Molar tooth sign on MRI (HP:0002419)	2.70022509
37	Tubular atrophy (HP:0000092)	2.64103889
38	Prominent metopic ridge (HP:0005487)	2.63986534
39	Nephrogenic diabetes insipidus (HP:0009806)	2.60996926
40	Abnormality of the metopic suture (HP:0005556)	2.60572747
41	Abnormality of the renal medulla (HP:0100957)	2.56384284
42	Bile duct proliferation (HP:0001408)	2.56136585
43	Abnormal biliary tract physiology (HP:0012439)	2.56136585
44	Hydroureter (HP:0000072)	2.46882752
45	Large for gestational age (HP:0001520)	2.42563432
46	Male infertility (HP:0003251)	2.33753486
47	Abnormal ciliary motility (HP:0012262)	2.32537720
48	Polyuria (HP:0000103)	2.31808038
49	Abnormality of magnesium homeostasis (HP:0004921)	2.31201150
50	Hypsarrhythmia (HP:0002521)	2.30560780
51	Postaxial hand polydactyly (HP:0001162)	2.28940350
52	Genital tract atresia (HP:0001827)	2.28939401
53	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.28376877
54	EEG with generalized epileptiform discharges (HP:0011198)	2.27770753
55	Congenital hepatic fibrosis (HP:0002612)	2.27724797
56	Enlarged kidneys (HP:0000105)	2.27293764
57	Urethral obstruction (HP:0000796)	2.25081853
58	Epileptiform EEG discharges (HP:0011182)	2.24391044
59	Optic nerve hypoplasia (HP:0000609)	2.24192817
60	Vaginal atresia (HP:0000148)	2.21246620
61	Poor coordination (HP:0002370)	2.21199808
62	Furrowed tongue (HP:0000221)	2.20837675
63	Abnormality of macular pigmentation (HP:0008002)	2.19822195
64	Postaxial foot polydactyly (HP:0001830)	2.18984920
65	Rhinitis (HP:0012384)	2.18393225
66	Supernumerary spleens (HP:0009799)	2.15630835
67	Polyphagia (HP:0002591)	2.15117128
68	Hyperventilation (HP:0002883)	2.14382813
69	Glycosuria (HP:0003076)	2.14368662
70	Abnormality of urine glucose concentration (HP:0011016)	2.14368662
71	Abnormal urine output (HP:0012590)	2.13085802
72	Pancreatic islet-cell hyperplasia (HP:0004510)	2.11911445
73	Severe visual impairment (HP:0001141)	2.11531229
74	Drooling (HP:0002307)	2.10455399
75	Abnormal respiratory epithelium morphology (HP:0012253)	2.05478688
76	Abnormal respiratory motile cilium morphology (HP:0005938)	2.05478688
77	Abnormality of the parathyroid morphology (HP:0011766)	2.04733601
78	Increased intramyocellular lipid droplets (HP:0012240)	2.04189168
79	Median cleft lip (HP:0000161)	2.01554875
80	Aplasia/Hypoplasia of the lens (HP:0008063)	1.99711488
81	Atonic seizures (HP:0010819)	1.98938955
82	Cystic liver disease (HP:0006706)	1.98113936
83	Abnormality of renal resorption (HP:0011038)	1.98096539
84	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.95346415
85	Hemiparesis (HP:0001269)	1.95237990
86	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.91380071
87	Oculomotor apraxia (HP:0000657)	1.89524257
88	Unilateral renal agenesis (HP:0000122)	1.88934338
89	Sclerocornea (HP:0000647)	1.88430745
90	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.88265216
91	Abolished electroretinogram (ERG) (HP:0000550)	1.87892242
92	Excessive salivation (HP:0003781)	1.87867902
93	Increased hepatocellular lipid droplets (HP:0006565)	1.87845043
94	Amblyopia (HP:0000646)	1.87557943
95	Insulin-resistant diabetes mellitus (HP:0000831)	1.85525109
96	Hyperuricemia (HP:0002149)	1.84776278
97	Increased purine levels (HP:0004368)	1.84776278
98	Short foot (HP:0001773)	1.82626413
99	Abnormality of renal excretion (HP:0011036)	1.81391545
100	Congenital sensorineural hearing impairment (HP:0008527)	1.80616663

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.70120296
2	TAF1	3.28392557
3	MAP4K2	2.96503188
4	CASK	2.79340251
5	MAP3K4	2.77012762
6	PLK4	2.71813914
7	MAP3K9	2.58291071
8	FGFR2	2.53545216
9	STK38L	2.21300771
10	ERBB3	2.17218339
11	PLK2	2.15900232
12	WNK3	2.09378315
13	ACVR1B	1.91138388
14	DAPK2	1.74408186
15	MAP2K7	1.69787884
16	BCKDK	1.65433909
17	STK38	1.54961183
18	PTK2B	1.44002563
19	MARK1	1.41524627
20	BMPR2	1.38495371
21	INSRR	1.32693517
22	DDR2	1.28393159
23	ARAF	1.22221018
24	PNCK	1.21938883
25	TESK1	1.21564357
26	NTRK3	1.17913688
27	TAOK3	1.11259857
28	TNIK	1.10325857
29	ADRBK2	1.09564678
30	BMPR1B	1.04828476
31	STK39	0.99023008
32	CAMK2D	0.96043880
33	BRD4	0.95679919
34	CSNK1G1	0.95372303
35	MAPK7	0.95325245
36	PRKCE	0.89163643
37	FER	0.86131881
38	MAPK13	0.85877510
39	NTRK2	0.85031240
40	DYRK2	0.83281624
41	ERBB4	0.80609369
42	OXSR1	0.72570826
43	TIE1	0.72251550
44	UHMK1	0.72218718
45	STK16	0.71491543
46	MUSK	0.71352780
47	SGK2	0.70673508
48	NLK	0.69005417
49	TAOK1	0.68905801
50	PINK1	0.68539636
51	EIF2AK3	0.68112567
52	CAMK1G	0.66354083
53	FGFR3	0.65056908
54	MKNK2	0.62678313
55	PRKCG	0.60850849
56	CSNK1G2	0.59639717
57	GRK1	0.58868571
58	TEC	0.58561044
59	BCR	0.57886223
60	CAMK2A	0.56790540
61	PHKG2	0.56578505
62	PHKG1	0.56578505
63	CSNK1G3	0.53816571
64	FGR	0.53684631
65	MAP3K13	0.53665650
66	SGK494	0.50837257
67	SGK223	0.50837257
68	NME1	0.50250296
69	EPHA4	0.47733688
70	SGK3	0.47527548
71	WNK4	0.46657308
72	PRKG1	0.43467985
73	PKN1	0.43304243
74	PAK3	0.43263652
75	CDK3	0.43213380
76	NEK6	0.43108472
77	CSNK1A1L	0.42874839
78	PRKACA	0.42850121
79	CAMK2B	0.42079462
80	DAPK1	0.42044372
81	SGK1	0.41723366
82	PLK3	0.41170855
83	MOS	0.40185427
84	PRKACB	0.40033609
85	CAMK4	0.39321115
86	PDK2	0.39298391
87	EPHA3	0.37851145
88	CAMK1	0.36380246
89	PDK1	0.34902951
90	PDPK1	0.34813479
91	CDK9	0.34535992
92	BRAF	0.34341168
93	MAP2K6	0.34031268
94	GSK3A	0.33808045
95	GRK7	0.32373158
96	PIK3CG	0.29791052
97	SRPK1	0.29480727
98	CSNK1A1	0.29471860
99	PRKCZ	0.29262923
100	TRIM28	0.29074620

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.87440018
2	Butanoate metabolism_Homo sapiens_hsa00650	4.34104162
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	4.22919933
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.85154254
5	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.65131728
6	Protein export_Homo sapiens_hsa03060	2.48070512
7	Insulin secretion_Homo sapiens_hsa04911	2.13890103
8	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.12897376
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.98875404
10	Selenocompound metabolism_Homo sapiens_hsa00450	1.81187724
11	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.71059270
12	Taste transduction_Homo sapiens_hsa04742	1.63652326
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.60912394
14	Nicotine addiction_Homo sapiens_hsa05033	1.57004122
15	Propanoate metabolism_Homo sapiens_hsa00640	1.51372923
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.49714329
17	Collecting duct acid secretion_Homo sapiens_hsa04966	1.48711082
18	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.46143203
19	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.43405459
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.39704081
21	beta-Alanine metabolism_Homo sapiens_hsa00410	1.36725308
22	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.32586543
23	Olfactory transduction_Homo sapiens_hsa04740	1.31491593
24	GABAergic synapse_Homo sapiens_hsa04727	1.30482240
25	Phototransduction_Homo sapiens_hsa04744	1.28715761
26	Sulfur metabolism_Homo sapiens_hsa00920	1.27800148
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.24544342
28	Basal transcription factors_Homo sapiens_hsa03022	1.23887596
29	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.19821679
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.17492396
31	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.13762958
32	Type II diabetes mellitus_Homo sapiens_hsa04930	1.13476886
33	ABC transporters_Homo sapiens_hsa02010	1.12892532
34	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.11871001
35	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.11108179
36	Fatty acid degradation_Homo sapiens_hsa00071	1.09780486
37	Peroxisome_Homo sapiens_hsa04146	1.09612281
38	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.05776490
39	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.04391893
40	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.95635610
41	Glutamatergic synapse_Homo sapiens_hsa04724	0.95174323
42	Mineral absorption_Homo sapiens_hsa04978	0.93179909
43	Sphingolipid metabolism_Homo sapiens_hsa00600	0.92474302
44	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.91414521
45	Circadian entrainment_Homo sapiens_hsa04713	0.91171005
46	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.89930692
47	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.86196791
48	Type I diabetes mellitus_Homo sapiens_hsa04940	0.84005330
49	Regulation of autophagy_Homo sapiens_hsa04140	0.82597254
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.81770048
51	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.81669848
52	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.80816584
53	Cardiac muscle contraction_Homo sapiens_hsa04260	0.80549612
54	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.76547912
55	Circadian rhythm_Homo sapiens_hsa04710	0.74562498
56	Salivary secretion_Homo sapiens_hsa04970	0.73984442
57	Oxidative phosphorylation_Homo sapiens_hsa00190	0.73569709
58	Renin-angiotensin system_Homo sapiens_hsa04614	0.72619751
59	Vibrio cholerae infection_Homo sapiens_hsa05110	0.71985656
60	Linoleic acid metabolism_Homo sapiens_hsa00591	0.70486331
61	Serotonergic synapse_Homo sapiens_hsa04726	0.66012854
62	Fatty acid metabolism_Homo sapiens_hsa01212	0.64776373
63	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.64591237
64	Oocyte meiosis_Homo sapiens_hsa04114	0.61910863
65	Retinol metabolism_Homo sapiens_hsa00830	0.60739310
66	Renin secretion_Homo sapiens_hsa04924	0.60601419
67	Metabolic pathways_Homo sapiens_hsa01100	0.60029204
68	Homologous recombination_Homo sapiens_hsa03440	0.59651745
69	Bile secretion_Homo sapiens_hsa04976	0.58816166
70	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.58281631
71	Purine metabolism_Homo sapiens_hsa00230	0.57266610
72	Huntingtons disease_Homo sapiens_hsa05016	0.56920742
73	Long-term depression_Homo sapiens_hsa04730	0.54947312
74	Dopaminergic synapse_Homo sapiens_hsa04728	0.52722581
75	Cocaine addiction_Homo sapiens_hsa05030	0.51936258
76	Morphine addiction_Homo sapiens_hsa05032	0.51337079
77	cAMP signaling pathway_Homo sapiens_hsa04024	0.49679189
78	Amphetamine addiction_Homo sapiens_hsa05031	0.49540981
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49345906
80	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.48874552
81	Steroid biosynthesis_Homo sapiens_hsa00100	0.48715286
82	Pyruvate metabolism_Homo sapiens_hsa00620	0.48640197
83	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.47550060
84	Caffeine metabolism_Homo sapiens_hsa00232	0.44592367
85	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.44424052
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44208813
87	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.43865940
88	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.43023709
89	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.42624830
90	Lysine degradation_Homo sapiens_hsa00310	0.42101651
91	Glutathione metabolism_Homo sapiens_hsa00480	0.41564848
92	Chemical carcinogenesis_Homo sapiens_hsa05204	0.41196839
93	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.40128902
94	RNA transport_Homo sapiens_hsa03013	0.39370862
95	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.39066596
96	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.38540867
97	Pyrimidine metabolism_Homo sapiens_hsa00240	0.37523434
98	Non-homologous end-joining_Homo sapiens_hsa03450	0.35135302
99	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.34971700
100	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.33141811

ARMC4P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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