ARMC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ARM (armadillo/beta-catenin-like repeat) superfamily. The ARM repeat is a tandemly repeated sequence motif with approximately 40 amino acid long. This repeat is implicated in mediating protein-protein interactions. The encoded protein contains seven ARM repeats. Mutations in this gene are associated with primary bilateral macronodular adrenal hyperplasia, which is also known as ACTH-independent macronodular adrenal hyperplasia 2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.91327045
2negative regulation of erythrocyte differentiation (GO:0045647)6.02420311
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.81835948
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.81835948
5regulation of gamma-delta T cell differentiation (GO:0045586)5.65155106
6negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.61498674
7regulation of gamma-delta T cell activation (GO:0046643)5.40743512
8antigen processing and presentation of endogenous antigen (GO:0019883)5.36125878
9valine metabolic process (GO:0006573)4.79558368
10positive regulation of B cell differentiation (GO:0045579)4.47612323
11positive regulation of natural killer cell differentiation (GO:0032825)4.42870587
12response to peptidoglycan (GO:0032494)4.38685356
13JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)4.34672356
14natural killer cell differentiation (GO:0001779)4.32861868
15COPI coating of Golgi vesicle (GO:0048205)4.29590973
16Golgi transport vesicle coating (GO:0048200)4.29590973
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.00425434
18mannose metabolic process (GO:0006013)3.90324776
19positive thymic T cell selection (GO:0045059)3.87861692
20epithelial cell differentiation involved in prostate gland development (GO:0060742)3.83179976
21regulation of B cell differentiation (GO:0045577)3.57217884
223-UTR-mediated mRNA stabilization (GO:0070935)3.52877729
23positive regulation of histone deacetylation (GO:0031065)3.52200952
24regulation of interleukin-12 biosynthetic process (GO:0045075)3.51373587
25mucosal-associated lymphoid tissue development (GO:0048537)3.44591562
26Peyers patch development (GO:0048541)3.44591562
27pentose-phosphate shunt (GO:0006098)3.40553685
28Arp2/3 complex-mediated actin nucleation (GO:0034314)3.31228466
29activation of MAPKKK activity (GO:0000185)3.30749628
30mature B cell differentiation involved in immune response (GO:0002313)3.27452813
31negative regulation of glycoprotein biosynthetic process (GO:0010561)3.24243111
32B cell mediated immunity (GO:0019724)3.19399868
33tricarboxylic acid metabolic process (GO:0072350)3.16897827
34negative regulation of cell size (GO:0045792)3.16756206
35modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.08532536
36positive regulation by organism of defense response of other organism involved in symbiotic interact3.08532536
37modulation by symbiont of host immune response (GO:0052553)3.08532536
38positive regulation by symbiont of host defense response (GO:0052509)3.08532536
39modulation by symbiont of host defense response (GO:0052031)3.08532536
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.08532536
41lipopolysaccharide-mediated signaling pathway (GO:0031663)3.08237982
42regulation of interferon-beta biosynthetic process (GO:0045357)3.06134384
43regulation of erythrocyte differentiation (GO:0045646)3.02154439
44germinal center formation (GO:0002467)3.01459457
45embryonic process involved in female pregnancy (GO:0060136)2.99500530
46positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.98055623
47NIK/NF-kappaB signaling (GO:0038061)2.96475674
48activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.96150564
49positive regulation of nuclease activity (GO:0032075)2.92959959
50regulation of natural killer cell differentiation (GO:0032823)2.92954480
51regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.88410845
52regulation of T-helper 2 cell differentiation (GO:0045628)2.87419791
53positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.85930935
54establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.84954189
55mitochondrion transport along microtubule (GO:0047497)2.84954189
56pinocytosis (GO:0006907)2.84350766
57creatine metabolic process (GO:0006600)2.84027506
58negative regulation of bone resorption (GO:0045779)2.82219180
59regulation of NFAT protein import into nucleus (GO:0051532)2.80996264
60histone H3 deacetylation (GO:0070932)2.80983456
61NADPH regeneration (GO:0006740)2.80841887
62maternal placenta development (GO:0001893)2.78944143
63maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.78798739
64positive regulation of interferon-alpha production (GO:0032727)2.77971113
65regulation of leukocyte degranulation (GO:0043300)2.77200596
66regulation of type I interferon-mediated signaling pathway (GO:0060338)2.76382089
67oxaloacetate metabolic process (GO:0006107)2.74820377
68GDP-mannose metabolic process (GO:0019673)2.74610415
69regulation of ARF GTPase activity (GO:0032312)2.74078731
70angiogenesis involved in wound healing (GO:0060055)2.72411898
71macrophage activation involved in immune response (GO:0002281)2.71594849
72thymic T cell selection (GO:0045061)2.70921225
73response to laminar fluid shear stress (GO:0034616)2.69927743
74L-alpha-amino acid transmembrane transport (GO:1902475)2.68880868
75B cell receptor signaling pathway (GO:0050853)2.67840916
76regulation of nuclease activity (GO:0032069)2.67175052
77neutrophil activation involved in immune response (GO:0002283)2.66696922
78regulation of myeloid leukocyte mediated immunity (GO:0002886)2.66694019
79cellular response to virus (GO:0098586)2.65622320
80positive regulation of lamellipodium assembly (GO:0010592)2.65205566
81negative regulation of myeloid cell apoptotic process (GO:0033033)2.63192673
82negative regulation of B cell apoptotic process (GO:0002903)2.62744474
83regulation of chemokine biosynthetic process (GO:0045073)2.62718084
84phosphatidylglycerol biosynthetic process (GO:0006655)2.62528150
85apoptotic process involved in morphogenesis (GO:0060561)2.61671365
86regulation of mast cell degranulation (GO:0043304)2.60931417
87response to muramyl dipeptide (GO:0032495)2.60634661
88regulation of interferon-alpha production (GO:0032647)2.60195724
89positive T cell selection (GO:0043368)2.59892246
90response to type I interferon (GO:0034340)2.59737120
91barbed-end actin filament capping (GO:0051016)2.59649639
92establishment of mitochondrion localization (GO:0051654)2.59217027
93mature B cell differentiation (GO:0002335)2.59115118
94RNA destabilization (GO:0050779)2.57751251
95UV protection (GO:0009650)2.56871900
96intracellular estrogen receptor signaling pathway (GO:0030520)2.55469877
97histone H4 deacetylation (GO:0070933)2.55294505
98positive regulation of lipoprotein lipase activity (GO:0051006)2.55239284
99positive regulation of triglyceride lipase activity (GO:0061365)2.55239284
100protein retention in ER lumen (GO:0006621)2.54100392
101endoplasmic reticulum unfolded protein response (GO:0030968)2.53305141
102negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.52969905
103regulation of mammary gland epithelial cell proliferation (GO:0033599)2.52879063
104cellular response to type I interferon (GO:0071357)2.52823752
105type I interferon signaling pathway (GO:0060337)2.52823752
106stress fiber assembly (GO:0043149)2.51831098
107modulation by symbiont of host cellular process (GO:0044068)2.51809617
108modulation by virus of host process (GO:0019054)2.51794090
109actin nucleation (GO:0045010)2.50127099
110regulation of monocyte differentiation (GO:0045655)2.49897378
111peptidyl-arginine omega-N-methylation (GO:0035247)2.49844792
112immunoglobulin mediated immune response (GO:0016064)2.49386327
113regulation of natural killer cell mediated immunity (GO:0002715)2.49126015
114regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.49126015
115tolerance induction (GO:0002507)2.48137948
116T cell apoptotic process (GO:0070231)2.47850463
117myeloid dendritic cell differentiation (GO:0043011)2.47425238
118negative regulation of glycoprotein metabolic process (GO:1903019)2.46870115
119positive regulation of protein deacetylation (GO:0090312)2.46810577
120antigen processing and presentation via MHC class Ib (GO:0002475)2.45638858
121positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.44351624
122ganglioside metabolic process (GO:0001573)2.44318507
123retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.42506534
124positive regulation of fatty acid biosynthetic process (GO:0045723)2.41900152
125natural killer cell activation (GO:0030101)2.41873283
126spliceosomal tri-snRNP complex assembly (GO:0000244)2.41383912
127growth hormone receptor signaling pathway (GO:0060396)2.40363958
128dosage compensation (GO:0007549)2.39890916
129detection of bacterium (GO:0016045)2.39662574
130snRNA metabolic process (GO:0016073)2.39642805
131cellular response to unfolded protein (GO:0034620)2.39269174
132positive regulation of triglyceride biosynthetic process (GO:0010867)2.38857341
133protein insertion into membrane (GO:0051205)2.37703509
134pentose metabolic process (GO:0019321)2.37198959
135glucose catabolic process (GO:0006007)2.36979648
136negative regulation of tumor necrosis factor production (GO:0032720)2.36603551
137positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.36596600
138positive regulation of natural killer cell mediated immunity (GO:0002717)2.36596600
139negative regulation of interleukin-8 production (GO:0032717)2.36465195
140negative regulation of phagocytosis (GO:0050765)2.36201698
141regulation of interleukin-2 biosynthetic process (GO:0045076)2.36151345
142T cell migration (GO:0072678)2.35598750
143negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.34338655
144positive regulation of macrophage differentiation (GO:0045651)2.33719604
145keratan sulfate catabolic process (GO:0042340)2.33405860
146T cell homeostasis (GO:0043029)2.33314541
147positive regulation of interferon-beta production (GO:0032728)2.32433671
148negative regulation of viral release from host cell (GO:1902187)2.32222530
149regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.31283106
150regulation of B cell receptor signaling pathway (GO:0050855)2.30971762
151regulation of B cell apoptotic process (GO:0002902)2.30736377
152regulation of vitamin D biosynthetic process (GO:0060556)2.29422613
153oligosaccharide catabolic process (GO:0009313)2.29304437
154regulation of tumor necrosis factor production (GO:0032680)2.28571170
155negative regulation of granulocyte differentiation (GO:0030853)2.28541049
156post-embryonic morphogenesis (GO:0009886)2.28514722
157positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.27019040
158detection of other organism (GO:0098543)2.26489816
159regulation of mast cell activation involved in immune response (GO:0033006)2.23942673
160retrograde transport, endosome to Golgi (GO:0042147)2.23530820
161response to protozoan (GO:0001562)2.20996402
162regulation of necrotic cell death (GO:0010939)2.20258770
163mitochondrion localization (GO:0051646)2.19901756
164toll-like receptor 3 signaling pathway (GO:0034138)2.19254961
165regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.18470363
166protein kinase C signaling (GO:0070528)2.18036963
167regulation of regulated secretory pathway (GO:1903305)2.17136587
168regulation of T-helper 1 cell differentiation (GO:0045625)2.17037460
169positive regulation of transcription factor import into nucleus (GO:0042993)2.16870069
170negative regulation of cytokine production involved in immune response (GO:0002719)2.16838750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.56912206
2GATA1_22025678_ChIP-Seq_K562_Human3.35643599
3MYC_22102868_ChIP-Seq_BL_Human3.18477234
4* VDR_21846776_ChIP-Seq_THP-1_Human2.97404219
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.81561684
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.78235542
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.65386387
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.59502560
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.44364604
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.42823071
11TCF7_22412390_ChIP-Seq_EML_Mouse2.20706037
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.19977142
13SCL_19346495_ChIP-Seq_HPC-7_Human2.18957638
14* ELK3_25401928_ChIP-Seq_HUVEC_Human2.11961800
15MAF_26560356_Chip-Seq_TH1_Human2.08275084
16VDR_24763502_ChIP-Seq_THP-1_Human2.03046326
17P68_20966046_ChIP-Seq_HELA_Human2.00642552
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.00151707
19IRF8_21731497_ChIP-ChIP_J774_Mouse1.99213061
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96871323
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96037329
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95860999
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.95846822
24* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.94350164
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.90053522
26KDM2B_26808549_Chip-Seq_DND41_Human1.89937339
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.89038971
28UTX_26944678_Chip-Seq_JUKART_Human1.88593394
29* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.87673465
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.87337838
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79108593
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.78357051
33LXR_22292898_ChIP-Seq_THP-1_Human1.78255215
34TET1_21451524_ChIP-Seq_MESCs_Mouse1.76879784
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.75393461
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74987429
37CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.70979433
38* SPI1_23127762_ChIP-Seq_K562_Human1.70745702
39KDM2B_26808549_Chip-Seq_K562_Human1.70558445
40BCL6_27268052_Chip-Seq_Bcells_Human1.69109063
41* MYB_26560356_Chip-Seq_TH2_Human1.68800698
42* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66426863
43* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63387269
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.62401627
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61657589
46* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.60816430
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58803204
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58098048
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.57292371
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56924407
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.55632110
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.53518792
53MYB_26560356_Chip-Seq_TH1_Human1.52833612
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.51830270
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51350596
56E2F7_22180533_ChIP-Seq_HELA_Human1.50846535
57* SPI1_23547873_ChIP-Seq_NB4_Human1.50473586
58SMC4_20622854_ChIP-Seq_HELA_Human1.49404508
59* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48499917
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.47834464
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45086143
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45044113
63* MAF_26560356_Chip-Seq_TH2_Human1.43940153
64* CREB1_26743006_Chip-Seq_LNCaP_Human1.41010187
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40904380
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.40775240
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.38398382
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38056204
69RACK7_27058665_Chip-Seq_MCF-7_Human1.36859302
70SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36728215
71RUNX_20019798_ChIP-Seq_JUKART_Human1.36173586
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35164252
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34901273
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.32692341
75* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30432965
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.30347614
77* NCOR1_26117541_ChIP-Seq_K562_Human1.29832754
78PHF8_20622854_ChIP-Seq_HELA_Human1.29649444
79PU.1_20513432_ChIP-Seq_Bcells_Mouse1.27626982
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26138974
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26018263
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25353936
83FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.25315537
84* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.25155409
85CIITA_25753668_ChIP-Seq_RAJI_Human1.25033676
86PPARA_22158963_ChIP-Seq_LIVER_Mouse1.24667226
87* CTCF_21964334_Chip-Seq_Bcells_Human1.23276212
88* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21389675
89SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20655302
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19890565
91CLOCK_20551151_ChIP-Seq_293T_Human1.19882378
92* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19454357
93GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18658305
94GATA1_19941826_ChIP-Seq_K562_Human1.17851792
95GATA1_19941827_ChIP-Seq_MEL_Mouse1.17471636
96CTCF_26484167_Chip-Seq_Bcells_Mouse1.17132633
97E2F1_20622854_ChIP-Seq_HELA_Human1.16038387
98CTCF_27219007_Chip-Seq_Bcells_Human1.15676619
99ELF1_20517297_ChIP-Seq_JURKAT_Human1.15562528
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14865234
101TP53_22127205_ChIP-Seq_IMR90_Human1.14364007
102MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14358194
103RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14252050
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13420723
105SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13293884
106FOXM1_23109430_ChIP-Seq_U2OS_Human1.12755939
107GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12514855
108FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11626722
109CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11624384
110KDM2B_26808549_Chip-Seq_JURKAT_Human1.11532904
111ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11361397
112* ATF3_27146783_Chip-Seq_COLON_Human1.10082444
113RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09763367
114ESR2_21235772_ChIP-Seq_MCF-7_Human1.09416768
115ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08072402
116* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07814582
117RXR_22158963_ChIP-Seq_LIVER_Mouse1.07570424
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07471093
119KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06796642
120YY1_22570637_ChIP-Seq_MALME-3M_Human1.06779200
121TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06525109
122* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05577552
123TFEB_21752829_ChIP-Seq_HELA_Human1.05309133
124ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04458788
125P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03236611
126CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02849891
127* GATA3_27048872_Chip-Seq_THYMUS_Human1.02179421
128PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01914857
129GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98773755
130RARB_24833708_ChIP-Seq_LIVER_Mouse0.98689080
131ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98140624
132STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97682321
133SA1_27219007_Chip-Seq_ERYTHROID_Human0.97153741
134ETS1_21867929_ChIP-Seq_TH2_Mouse0.97125260
135CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96673098
136PU_27001747_Chip-Seq_BMDM_Mouse0.96267263
137ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96239399
138SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96029007
139BCOR_27268052_Chip-Seq_Bcells_Human0.95722563
140PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95465009
141SA1_27219007_Chip-Seq_Bcells_Human0.95103418
142ZNF263_19887448_ChIP-Seq_K562_Human0.94259803
143NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93160197
144HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92832341
145* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92185680

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.16294352
2MP0005451_abnormal_body_composition3.08918781
3MP0003303_peritoneal_inflammation2.72425849
4MP0000685_abnormal_immune_system2.61966024
5MP0001835_abnormal_antigen_presentation2.57692469
6MP0003436_decreased_susceptibility_to2.34082974
7MP0004510_myositis2.28579400
8MP0009840_abnormal_foam_cell2.27047656
9MP0008260_abnormal_autophagy2.20671646
10MP0009333_abnormal_splenocyte_physiolog2.13029424
11MP0005387_immune_system_phenotype2.08056651
12MP0001790_abnormal_immune_system2.08056651
13MP0003566_abnormal_cell_adhesion2.07588854
14MP0002877_abnormal_melanocyte_morpholog2.06302012
15MP0009278_abnormal_bone_marrow1.96341574
16MP0000604_amyloidosis1.96025324
17MP0003329_amyloid_beta_deposits1.94132113
18MP0003705_abnormal_hypodermis_morpholog1.89544487
19MP0005000_abnormal_immune_tolerance1.88115625
20MP0001800_abnormal_humoral_immune1.84662354
21MP0006054_spinal_hemorrhage1.83593009
22MP0002452_abnormal_antigen_presenting1.82289230
23MP0002254_reproductive_system_inflammat1.81307096
24MP0005464_abnormal_platelet_physiology1.80714458
25MP0005025_abnormal_response_to1.79561555
26MP0005058_abnormal_lysosome_morphology1.77923361
27MP0002138_abnormal_hepatobiliary_system1.76573913
28MP0002723_abnormal_immune_serum1.76002964
29MP0001819_abnormal_immune_cell1.68620253
30MP0002419_abnormal_innate_immunity1.67479724
31MP0002420_abnormal_adaptive_immunity1.65877039
32MP0005671_abnormal_response_to1.64878321
33MP0004947_skin_inflammation1.64270630
34MP0002405_respiratory_system_inflammati1.63615450
35MP0010155_abnormal_intestine_physiology1.63490338
36MP0003763_abnormal_thymus_physiology1.62825345
37MP0003075_altered_response_to1.62495307
38MP0002398_abnormal_bone_marrow1.62284388
39MP0006082_CNS_inflammation1.59828379
40MP0010352_gastrointestinal_tract_polyps1.59574598
41MP0009785_altered_susceptibility_to1.52661629
42MP0000678_abnormal_parathyroid_gland1.51031221
43MP0000681_abnormal_thyroid_gland1.49876581
44MP0001845_abnormal_inflammatory_respons1.49643743
45MP0000465_gastrointestinal_hemorrhage1.46686024
46MP0003191_abnormal_cellular_cholesterol1.45881198
47MP0003866_abnormal_defecation1.45280239
48MP0000716_abnormal_immune_system1.44390238
49MP0001533_abnormal_skeleton_physiology1.44008428
50MP0005310_abnormal_salivary_gland1.43980425
51MP0001853_heart_inflammation1.43721240
52MP0001348_abnormal_lacrimal_gland1.43010217
53MP0005397_hematopoietic_system_phenotyp1.42929508
54MP0001545_abnormal_hematopoietic_system1.42929508
55MP0003724_increased_susceptibility_to1.42853138
56MP0000689_abnormal_spleen_morphology1.42464280
57MP0002396_abnormal_hematopoietic_system1.41551167
58MP0002722_abnormal_immune_system1.41528406
59MP0008438_abnormal_cutaneous_collagen1.40264297
60MP0003183_abnormal_peptide_metabolism1.38987090
61MP0004808_abnormal_hematopoietic_stem1.36595529
62MP0002693_abnormal_pancreas_physiology1.35750854
63MP0003172_abnormal_lysosome_physiology1.35461420
64MP0000703_abnormal_thymus_morphology1.32257937
65MP0005023_abnormal_wound_healing1.31950655
66MP0002429_abnormal_blood_cell1.31317641
67MP0002148_abnormal_hypersensitivity_rea1.30680493
68MP0002166_altered_tumor_susceptibility1.29658967
69MP0002249_abnormal_larynx_morphology1.28489624
70MP0004858_abnormal_nervous_system1.26673307
71MP0008961_abnormal_basal_metabolism1.21009537
72MP0003283_abnormal_digestive_organ1.20492529
73MP0008469_abnormal_protein_level1.19314648
74MP0009764_decreased_sensitivity_to1.19185855
75MP0002933_joint_inflammation1.19149679
76MP0004185_abnormal_adipocyte_glucose1.18271751
77MP0001873_stomach_inflammation1.18223345
78MP0000015_abnormal_ear_pigmentation1.14917010
79MP0002139_abnormal_hepatobiliary_system1.13833179
80MP0005076_abnormal_cell_differentiation1.11273944
81MP0005360_urolithiasis1.10363166
82MP0003279_aneurysm1.09670415
83MP0001944_abnormal_pancreas_morphology1.05757192
84MP0000003_abnormal_adipose_tissue1.04816289
85MP0001849_ear_inflammation1.04560083
86MP0005166_decreased_susceptibility_to1.04320623
87MP0009643_abnormal_urine_homeostasis1.02360327
88MP0000858_altered_metastatic_potential1.01585676
89MP0003448_altered_tumor_morphology1.01371883
90MP0000490_abnormal_crypts_of0.99981470
91MP0000609_abnormal_liver_physiology0.99199907
92MP0002822_catalepsy0.97945036
93MP0005375_adipose_tissue_phenotype0.95991343
94MP0002998_abnormal_bone_remodeling0.95866119
95MP0003091_abnormal_cell_migration0.94582528
96MP0005083_abnormal_biliary_tract0.89524650
97MP0002132_abnormal_respiratory_system0.88430412
98MP0002332_abnormal_exercise_endurance0.88394172
99MP0003656_abnormal_erythrocyte_physiolo0.88122905
100MP0003828_pulmonary_edema0.87485051
101MP0001243_abnormal_dermal_layer0.86924017
102MP0002653_abnormal_ependyma_morphology0.86870636
103MP0010307_abnormal_tumor_latency0.84847996
104MP0003795_abnormal_bone_structure0.84582357
105MP0002019_abnormal_tumor_incidence0.83840177
106MP0000598_abnormal_liver_morphology0.83106070
107MP0005666_abnormal_adipose_tissue0.82413693
108MP0000733_abnormal_muscle_development0.81863843
109MP0000249_abnormal_blood_vessel0.80047213
110MP0000343_altered_response_to0.79791671
111MP0004859_abnormal_synaptic_plasticity0.79552916
112MP0002928_abnormal_bile_duct0.79029662
113MP0004233_abnormal_muscle_weight0.78224440
114MP0003045_fibrosis0.77394934
115MP0000767_abnormal_smooth_muscle0.76800544
116MP0008995_early_reproductive_senescence0.76701367
117MP0005390_skeleton_phenotype0.76289226
118MP0002136_abnormal_kidney_physiology0.74981367
119MP0005220_abnormal_exocrine_pancreas0.74916942
120MP0002006_tumorigenesis0.74506187
121MP0001663_abnormal_digestive_system0.73325092
122MP0001915_intracranial_hemorrhage0.73077776
123MP0003453_abnormal_keratinocyte_physiol0.71030612
124MP0009931_abnormal_skin_appearance0.70655696
125MP0009384_cardiac_valve_regurgitation0.70269500
126MP0005670_abnormal_white_adipose0.68882404
127MP0008874_decreased_physiological_sensi0.68061671
128MP0005257_abnormal_intraocular_pressure0.66652557
129MP0008004_abnormal_stomach_pH0.66454389
130MP0005423_abnormal_somatic_nervous0.65449518
131MP0000759_abnormal_skeletal_muscle0.64990473
132MP0001764_abnormal_homeostasis0.63974154
133MP0005334_abnormal_fat_pad0.63838074

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.79505743
2Interstitial pulmonary disease (HP:0006530)3.35335436
3Mucopolysacchariduria (HP:0008155)3.33807282
4Urinary glycosaminoglycan excretion (HP:0003541)3.33807282
5Mediastinal lymphadenopathy (HP:0100721)3.13391666
6Dysostosis multiplex (HP:0000943)3.08275110
7Chronic otitis media (HP:0000389)3.07112770
8Recurrent abscess formation (HP:0002722)3.02914819
9Abnormality of polysaccharide metabolism (HP:0011012)3.02110199
10Abnormality of glycosaminoglycan metabolism (HP:0004371)3.02110199
11Abnormality of mucopolysaccharide metabolism (HP:0011020)3.02110199
12J-shaped sella turcica (HP:0002680)2.99846527
13Cellulitis (HP:0100658)2.95545119
14Chronic obstructive pulmonary disease (HP:0006510)2.89100650
15Obstructive lung disease (HP:0006536)2.89100650
16Loss of speech (HP:0002371)2.89006383
17Cerebral aneurysm (HP:0004944)2.87359917
18Abnormality of the nasal mucosa (HP:0000433)2.84472730
19Nasal polyposis (HP:0100582)2.83590041
20Increased cerebral lipofuscin (HP:0011813)2.82719495
21Agammaglobulinemia (HP:0004432)2.80122437
22Elevated erythrocyte sedimentation rate (HP:0003565)2.79238421
23Hypertensive crisis (HP:0100735)2.69607931
24Pustule (HP:0200039)2.69013232
25Cervical subluxation (HP:0003308)2.67361646
26Neurofibrillary tangles (HP:0002185)2.67213088
27Colitis (HP:0002583)2.67184935
28Truncus arteriosus (HP:0001660)2.66758754
29Gastrointestinal inflammation (HP:0004386)2.64133390
30Vacuolated lymphocytes (HP:0001922)2.61143503
31Petechiae (HP:0000967)2.57872317
32Inflammation of the large intestine (HP:0002037)2.56855989
33Abnormality of the thoracic spine (HP:0100711)2.56033015
34Recurrent viral infections (HP:0004429)2.55422065
35Recurrent fungal infections (HP:0002841)2.54981182
36Increased neuronal autofluorescent lipopigment (HP:0002074)2.53938713
37Polygenic inheritance (HP:0010982)2.53100478
38Neuronal loss in central nervous system (HP:0002529)2.51985915
39Acute lymphatic leukemia (HP:0006721)2.50771911
40Recurrent bacterial skin infections (HP:0005406)2.49554382
41Myositis (HP:0100614)2.48294587
42Supranuclear gaze palsy (HP:0000605)2.46607782
43Protrusio acetabuli (HP:0003179)2.44106262
44Broad face (HP:0000283)2.42960606
45Thrombocytosis (HP:0001894)2.42801203
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.42753777
47IgM deficiency (HP:0002850)2.42681998
48Hemorrhage of the eye (HP:0011885)2.42441986
49Abnormality of the columella (HP:0009929)2.41967390
50Abnormal platelet function (HP:0011869)2.39518568
51Impaired platelet aggregation (HP:0003540)2.39518568
52Exercise-induced myalgia (HP:0003738)2.38686138
53Diminished motivation (HP:0000745)2.38391068
54Increased IgE level (HP:0003212)2.37278192
55Hypoglycemic seizures (HP:0002173)2.32661880
56Autoimmune thrombocytopenia (HP:0001973)2.30954993
57Apathy (HP:0000741)2.29299933
58Asymmetric septal hypertrophy (HP:0001670)2.27422163
59Spontaneous hematomas (HP:0007420)2.26387559
60Hypoglycemic coma (HP:0001325)2.26018522
61Achilles tendon contracture (HP:0001771)2.25972317
62Hyperinsulinemic hypoglycemia (HP:0000825)2.25771605
63Cerebral inclusion bodies (HP:0100314)2.24190223
64Polycythemia (HP:0001901)2.23192852
65Abnormality of macrophages (HP:0004311)2.22988154
66Late onset (HP:0003584)2.22272845
67Ulnar bowing (HP:0003031)2.21424491
68Hyperacusis (HP:0010780)2.18781278
69Centrally nucleated skeletal muscle fibers (HP:0003687)2.17820441
70Emphysema (HP:0002097)2.17222933
71Increased serum ferritin (HP:0003281)2.16868036
72Recurrent bronchitis (HP:0002837)2.16519940
73Purpura (HP:0000979)2.14420865
74Bulbar palsy (HP:0001283)2.13618706
75Thin bony cortex (HP:0002753)2.13072818
76Abnormality of the Achilles tendon (HP:0005109)2.11195260
77Reticulocytosis (HP:0001923)2.10904838
78Stridor (HP:0010307)2.08972424
79Obstructive sleep apnea (HP:0002870)2.08630290
80Systemic lupus erythematosus (HP:0002725)2.06305827
81Gingivitis (HP:0000230)2.03384306
82Deep venous thrombosis (HP:0002625)2.01236893
83Distal lower limb amyotrophy (HP:0008944)1.99846031
84Joint stiffness (HP:0001387)1.97879808
85Abnormality of complement system (HP:0005339)1.95777533
86Premature rupture of membranes (HP:0001788)1.95253442
87Peritonitis (HP:0002586)1.95118983
88Vertebral compression fractures (HP:0002953)1.94963292
89Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.93445102
90Orchitis (HP:0100796)1.91875030
91Complement deficiency (HP:0004431)1.90929503
92Deformed sella turcica (HP:0002681)1.89412292
93Seborrheic dermatitis (HP:0001051)1.88293992
94Abnormality of the lumbar spine (HP:0100712)1.88220347
95Viral hepatitis (HP:0006562)1.87120173
96Disproportionate tall stature (HP:0001519)1.86959511
97Gastrointestinal stroma tumor (HP:0100723)1.86771541
98Verrucae (HP:0200043)1.86654768
99Papilloma (HP:0012740)1.86654768
100Ulnar deviation of the wrist (HP:0003049)1.86250690
101Severe short stature (HP:0003510)1.86012431
102Hyperthyroidism (HP:0000836)1.85869896
103Abnormality of T cell physiology (HP:0011840)1.85466170
104Supernumerary nipples (HP:0002558)1.85163798
105Abnormality of iron homeostasis (HP:0011031)1.84483803
106Self-mutilation (HP:0000742)1.83902362
107Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.83046024
108Abnormality of transition element cation homeostasis (HP:0011030)1.82948727
109Nonimmune hydrops fetalis (HP:0001790)1.82477149
110Recurrent skin infections (HP:0001581)1.82340032
111Abnormality of glycolipid metabolism (HP:0010969)1.81357658
112Abnormality of liposaccharide metabolism (HP:0010968)1.81357658
113Abnormality of glycosphingolipid metabolism (HP:0004343)1.81357658
114Broad distal phalanx of finger (HP:0009836)1.80484012
115Myopathic facies (HP:0002058)1.80175690
116Chronic mucocutaneous candidiasis (HP:0002728)1.79845319
117Recurrent cutaneous fungal infections (HP:0011370)1.79845319
118Thoracolumbar scoliosis (HP:0002944)1.79546669
119Hypertriglyceridemia (HP:0002155)1.79226222
120Abnormality of the fingertips (HP:0001211)1.79035260
121Easy fatigability (HP:0003388)1.78941449
122Prolonged neonatal jaundice (HP:0006579)1.78826419
123Abnormality of endocrine pancreas physiology (HP:0012093)1.78607122
124Abnormality of the pancreatic islet cells (HP:0006476)1.78607122
125Myocardial infarction (HP:0001658)1.77902826
126Increased variability in muscle fiber diameter (HP:0003557)1.77318426
127Abnormal large intestine physiology (HP:0012700)1.76000352
128Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.75982561
129Meningitis (HP:0001287)1.75891890
130Arterial thrombosis (HP:0004420)1.75717846
131Ragged-red muscle fibers (HP:0003200)1.75428356
132Abnormality of T cells (HP:0002843)1.74900902
133Restrictive lung disease (HP:0002091)1.74765434
134Amyloidosis (HP:0011034)1.74253174
135Aneurysm (HP:0002617)1.73784155
136Symptomatic seizures (HP:0011145)1.73676735
137Aortic aneurysm (HP:0004942)1.72552752
138Insulin resistance (HP:0000855)1.71702176
139Thoracic kyphosis (HP:0002942)1.70271596
140Hand muscle atrophy (HP:0009130)1.68693706
141Recurrent gram-negative bacterial infections (HP:0005420)1.68624303
142Pili torti (HP:0003777)1.68106408
143Periodontitis (HP:0000704)1.67483632
144Prolonged bleeding time (HP:0003010)1.67404250
145Dilatation of the ascending aorta (HP:0005111)1.67390539
146Panhypogammaglobulinemia (HP:0003139)1.67284914
147Progressive neurologic deterioration (HP:0002344)1.67284188
148Mitral valve prolapse (HP:0001634)1.67145250
149Hematochezia (HP:0002573)1.66983040
150Chest pain (HP:0100749)1.66303068
151Osteolytic defects of the phalanges of the hand (HP:0009771)1.66054730
152Osteolytic defects of the hand bones (HP:0009699)1.66054730
153Epistaxis (HP:0000421)1.65694568

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.31378574
2TRIB33.74705548
3ICK3.42485150
4ERN13.40241182
5MAP4K13.17998243
6MAP3K103.11786275
7SMG12.78897832
8TAOK22.77950636
9JAK32.76645428
10PKN22.64407403
11EEF2K2.47551444
12NME22.05893236
13TYK22.03144596
14BTK1.98537634
15ZAP701.92711798
16FLT31.91365302
17FGFR41.87520282
18TBK11.84068506
19PASK1.82349604
20KIT1.71587386
21EPHB11.64811309
22RIPK11.59533314
23CSF1R1.49576930
24JAK11.48703091
25INSRR1.47892293
26TTN1.40934987
27IRAK31.40703378
28MAP3K31.40556593
29TAOK31.39814165
30HIPK21.37763639
31PRKD31.37702466
32MST1R1.36278615
33EPHA31.36185405
34MAPK151.35116007
35SYK1.33546581
36RPS6KA41.32577435
37PTK61.30886916
38TGFBR21.27588348
39BMX1.25275129
40BLK1.23852675
41STK101.22707588
42SIK11.20101511
43MARK21.18815021
44LRRK21.17643143
45TNK21.15525272
46JAK21.14600590
47MAP2K31.13853668
48ITK1.07348206
49IKBKE1.06077910
50MAPK121.04937047
51MAPK111.04119672
52MAP3K111.03890109
53PDGFRA1.01377497
54MET1.01133383
55MAPK71.00412154
56KDR0.97414882
57GRK60.95917590
58RIPK40.95530602
59CDK120.95031542
60CHUK0.94371714
61PIM10.93497069
62IKBKB0.92181797
63CSK0.91705744
64MARK30.90770737
65HCK0.90750083
66IRAK20.89197003
67LCK0.88803574
68SCYL20.86707372
69MAP3K80.86010964
70PIM20.82562995
71IRAK40.81988836
72TEC0.80856426
73MAP3K10.80471902
74MOS0.78732501
75DAPK30.77234445
76DYRK1B0.77119933
77DDR20.75555785
78MAP3K140.75148172
79MAP3K60.71867975
80MATK0.71335733
81NLK0.68199806
82ABL20.68091555
83TGFBR10.67889168
84MAPK40.67591804
85MAPKAPK30.67159371
86RPS6KA20.66402495
87TESK20.65765223
88PTK20.65761288
89PKN10.65251493
90TAOK10.65182405
91RPS6KA60.63096222
92FES0.62085756
93MTOR0.61831923
94LYN0.61255370
95SIK20.58816835
96PAK40.57990994
97ALK0.57643410
98FGFR30.57313812
99CDC42BPA0.56482127
100PAK20.56131981
101MAPKAPK20.55995540
102PDK10.55972641
103GRK70.55741284
104MAP2K20.54863808
105PRKCH0.53643502
106PRKD20.52556989
107PDPK10.52314182
108RPS6KA50.52270960
109DMPK0.51433194
110RPS6KA10.51198622
111RPS6KC10.50843483
112RPS6KL10.50843483
113TESK10.49277436
114NEK20.49223413
115PDGFRB0.49052913
116CDK60.48620884
117BCKDK0.48530146
118CDK190.48280945
119CDK40.48102691
120STK40.47789135
121CSNK1A1L0.46766003
122MAP3K70.46714930
123LMTK20.45171712
124DAPK10.44256878
125MAP2K60.43245045
126PRKG20.42814990
127AURKA0.42649683
128EGFR0.42118541
129CSNK1G30.41124796
130CDK70.40429759
131DYRK30.39768534
132PRKAA10.39161229
133ARAF0.39073050
134MAPK30.39024136
135CDK90.38344166
136TLK10.36322695

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.01705762
2Other glycan degradation_Homo sapiens_hsa005112.65856120
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.58983382
4Leishmaniasis_Homo sapiens_hsa051402.28440184
5B cell receptor signaling pathway_Homo sapiens_hsa046622.26726417
6Osteoclast differentiation_Homo sapiens_hsa043802.18975951
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.16182000
8Primary immunodeficiency_Homo sapiens_hsa053402.01044984
9Antigen processing and presentation_Homo sapiens_hsa046122.00694155
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.98553862
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.86421732
12Lysosome_Homo sapiens_hsa041421.85439978
13Acute myeloid leukemia_Homo sapiens_hsa052211.84704890
14Chronic myeloid leukemia_Homo sapiens_hsa052201.78406698
15Measles_Homo sapiens_hsa051621.75179421
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.67274351
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.58828398
18Prion diseases_Homo sapiens_hsa050201.58827801
19Systemic lupus erythematosus_Homo sapiens_hsa053221.55047515
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47407862
21Staphylococcus aureus infection_Homo sapiens_hsa051501.44066754
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.43441383
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.41575836
24Apoptosis_Homo sapiens_hsa042101.41525724
25Toxoplasmosis_Homo sapiens_hsa051451.40153779
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.40017444
27Prolactin signaling pathway_Homo sapiens_hsa049171.39342431
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.37231280
29Legionellosis_Homo sapiens_hsa051341.36549043
30Insulin resistance_Homo sapiens_hsa049311.33288032
31T cell receptor signaling pathway_Homo sapiens_hsa046601.32601276
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31537586
33Shigellosis_Homo sapiens_hsa051311.31211262
34Selenocompound metabolism_Homo sapiens_hsa004501.29998576
35Hepatitis B_Homo sapiens_hsa051611.28602545
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.26651896
37Hematopoietic cell lineage_Homo sapiens_hsa046401.25315176
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24765167
39Fructose and mannose metabolism_Homo sapiens_hsa000511.23383639
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20711896
41Tuberculosis_Homo sapiens_hsa051521.15803261
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15214714
43TNF signaling pathway_Homo sapiens_hsa046681.12075924
44Pertussis_Homo sapiens_hsa051331.09953178
45Neurotrophin signaling pathway_Homo sapiens_hsa047221.08730102
46Notch signaling pathway_Homo sapiens_hsa043301.06941909
47Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.04595647
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02033423
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00707837
50Influenza A_Homo sapiens_hsa051641.00128077
51Lysine degradation_Homo sapiens_hsa003100.98975631
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97627107
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96041976
54Rheumatoid arthritis_Homo sapiens_hsa053230.95827612
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.95823616
56HTLV-I infection_Homo sapiens_hsa051660.95191936
57Platelet activation_Homo sapiens_hsa046110.94699754
58Type II diabetes mellitus_Homo sapiens_hsa049300.94614351
59Viral carcinogenesis_Homo sapiens_hsa052030.94478494
60Alcoholism_Homo sapiens_hsa050340.94054815
61Non-small cell lung cancer_Homo sapiens_hsa052230.93848628
62Amoebiasis_Homo sapiens_hsa051460.92854549
63Salmonella infection_Homo sapiens_hsa051320.91710839
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91232034
65Herpes simplex infection_Homo sapiens_hsa051680.90517108
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.90513587
67VEGF signaling pathway_Homo sapiens_hsa043700.90132742
68Viral myocarditis_Homo sapiens_hsa054160.89698818
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.89170568
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88189348
71Asthma_Homo sapiens_hsa053100.87349791
72Malaria_Homo sapiens_hsa051440.86760635
73N-Glycan biosynthesis_Homo sapiens_hsa005100.86560575
74Small cell lung cancer_Homo sapiens_hsa052220.84520615
75Galactose metabolism_Homo sapiens_hsa000520.83971320
76mTOR signaling pathway_Homo sapiens_hsa041500.82790751
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77371270
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.75693972
79Pancreatic cancer_Homo sapiens_hsa052120.75470511
80GnRH signaling pathway_Homo sapiens_hsa049120.75000414
81Proteoglycans in cancer_Homo sapiens_hsa052050.74696844
82Allograft rejection_Homo sapiens_hsa053300.74532883
83Chemokine signaling pathway_Homo sapiens_hsa040620.73487231
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73137399
85Protein digestion and absorption_Homo sapiens_hsa049740.72265231
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71047424
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.70840331
88Focal adhesion_Homo sapiens_hsa045100.70625474
89AMPK signaling pathway_Homo sapiens_hsa041520.70317892
90Thyroid cancer_Homo sapiens_hsa052160.69557702
91ErbB signaling pathway_Homo sapiens_hsa040120.68520681
92Epstein-Barr virus infection_Homo sapiens_hsa051690.68487894
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.67508367
94MAPK signaling pathway_Homo sapiens_hsa040100.67093801
95Bladder cancer_Homo sapiens_hsa052190.66234942
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66096755
97African trypanosomiasis_Homo sapiens_hsa051430.65950803
98Phagosome_Homo sapiens_hsa041450.64675053
99Renin-angiotensin system_Homo sapiens_hsa046140.64229666
100Biosynthesis of amino acids_Homo sapiens_hsa012300.62420161
101ABC transporters_Homo sapiens_hsa020100.62417467
102Endometrial cancer_Homo sapiens_hsa052130.61657306
103Graft-versus-host disease_Homo sapiens_hsa053320.61570153
104Sphingolipid metabolism_Homo sapiens_hsa006000.60553551
105Pentose phosphate pathway_Homo sapiens_hsa000300.60471699
106HIF-1 signaling pathway_Homo sapiens_hsa040660.60158761
107Hepatitis C_Homo sapiens_hsa051600.59801883
108Choline metabolism in cancer_Homo sapiens_hsa052310.59290462
109Sulfur relay system_Homo sapiens_hsa041220.58351132
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57908352
111Base excision repair_Homo sapiens_hsa034100.53449077
112Inositol phosphate metabolism_Homo sapiens_hsa005620.52906885
113MicroRNAs in cancer_Homo sapiens_hsa052060.52503132
114Glioma_Homo sapiens_hsa052140.50793908
115One carbon pool by folate_Homo sapiens_hsa006700.50419215
116Sulfur metabolism_Homo sapiens_hsa009200.49083341
117Autoimmune thyroid disease_Homo sapiens_hsa053200.48662588
118Insulin signaling pathway_Homo sapiens_hsa049100.47747292
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47530739
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46865570
121Complement and coagulation cascades_Homo sapiens_hsa046100.46716547
122Protein export_Homo sapiens_hsa030600.46249701
123Endocytosis_Homo sapiens_hsa041440.45807611
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43488389
125ECM-receptor interaction_Homo sapiens_hsa045120.41584783
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41043000
127Renal cell carcinoma_Homo sapiens_hsa052110.39528279
128Caffeine metabolism_Homo sapiens_hsa002320.38411900
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37243438
130DNA replication_Homo sapiens_hsa030300.35571416
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34809626
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31279829
133Ribosome_Homo sapiens_hsa030100.31265283

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