ARMC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The function of this gene's protein product has not been determined. A related protein in mouse suggests that this protein has a conserved function. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-arginine omega-N-methylation (GO:0035247)5.19363892
2negative regulation of microtubule polymerization (GO:0031115)5.13456227
3DNA strand elongation involved in DNA replication (GO:0006271)4.97221224
4histone arginine methylation (GO:0034969)4.84973054
5DNA strand elongation (GO:0022616)4.83443534
6proline biosynthetic process (GO:0006561)4.82863069
7peptidyl-arginine methylation (GO:0018216)4.42173034
8peptidyl-arginine N-methylation (GO:0035246)4.42173034
9telomere maintenance via semi-conservative replication (GO:0032201)4.28682633
10DNA replication initiation (GO:0006270)4.26600504
11pyrimidine nucleobase catabolic process (GO:0006208)4.14378280
12protein maturation by protein folding (GO:0022417)4.09840601
13cell migration in hindbrain (GO:0021535)3.95018178
14establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.93741512
15mitochondrion transport along microtubule (GO:0047497)3.93741512
16mitotic chromosome condensation (GO:0007076)3.92064172
17L-serine metabolic process (GO:0006563)3.90644476
18positive regulation of synapse maturation (GO:0090129)3.83263819
19establishment of mitochondrion localization (GO:0051654)3.82966391
20formation of translation preinitiation complex (GO:0001731)3.81868044
21deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.72287634
22negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.70632588
23IMP biosynthetic process (GO:0006188)3.68501330
24cullin deneddylation (GO:0010388)3.63730612
25ribosomal small subunit biogenesis (GO:0042274)3.61051494
26pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.57351455
27establishment of integrated proviral latency (GO:0075713)3.50176778
28rRNA transcription (GO:0009303)3.48208318
29nucleobase-containing small molecule interconversion (GO:0015949)3.45598569
30establishment of protein localization to mitochondrial membrane (GO:0090151)3.41858047
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.39800549
32protein complex localization (GO:0031503)3.38213076
33regulation of short-term neuronal synaptic plasticity (GO:0048172)3.37558315
34pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.37366419
35protein deneddylation (GO:0000338)3.37212545
36guanosine-containing compound biosynthetic process (GO:1901070)3.36853561
37de novo protein folding (GO:0006458)3.36494901
38synaptic vesicle maturation (GO:0016188)3.36201828
39pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.34489832
40tRNA methylation (GO:0030488)3.33246550
41telomere maintenance via recombination (GO:0000722)3.32439599
42mitotic sister chromatid segregation (GO:0000070)3.32096464
43ribosome biogenesis (GO:0042254)3.31506136
44pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.29561880
45mitotic metaphase plate congression (GO:0007080)3.29219746
46de novo posttranslational protein folding (GO:0051084)3.28636184
47negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.27422602
48ribosome assembly (GO:0042255)3.26752347
49IMP metabolic process (GO:0046040)3.26326632
50mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.24890531
51spliceosomal snRNP assembly (GO:0000387)3.24547041
52base-excision repair (GO:0006284)3.22299272
53layer formation in cerebral cortex (GO:0021819)3.20799990
54UTP biosynthetic process (GO:0006228)3.20668710
55regulation of mitochondrial translation (GO:0070129)3.20516546
56base-excision repair, AP site formation (GO:0006285)3.20149652
57Golgi transport vesicle coating (GO:0048200)3.19946682
58COPI coating of Golgi vesicle (GO:0048205)3.19946682
59synaptic vesicle exocytosis (GO:0016079)3.17204239
60heterochromatin organization (GO:0070828)3.16009579
61nucleobase biosynthetic process (GO:0046112)3.14530490
62ribosomal large subunit biogenesis (GO:0042273)3.13967640
63chaperone-mediated protein transport (GO:0072321)3.13356380
64mitotic recombination (GO:0006312)3.13120404
65mitochondrial RNA metabolic process (GO:0000959)3.13102367
66proline metabolic process (GO:0006560)3.12682640
67negative regulation of mRNA processing (GO:0050686)3.11049466
68nuclear envelope reassembly (GO:0031468)3.08917956
69mitotic nuclear envelope reassembly (GO:0007084)3.08917956
70pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.08451790
71pentose-phosphate shunt (GO:0006098)3.07669645
72purine nucleobase biosynthetic process (GO:0009113)3.06882282
73energy coupled proton transport, down electrochemical gradient (GO:0015985)3.05862442
74ATP synthesis coupled proton transport (GO:0015986)3.05862442
75negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05170136
76mitochondrial fusion (GO:0008053)3.03345475
77glutamate secretion (GO:0014047)3.03189953
78pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.02226135
79nucleobase catabolic process (GO:0046113)3.02130951
80protein localization to chromosome, centromeric region (GO:0071459)2.99543213
81CTP biosynthetic process (GO:0006241)2.96768603
82CTP metabolic process (GO:0046036)2.96768603
83regulation of translational termination (GO:0006449)2.96007689
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.95376419
85cellular protein complex localization (GO:0034629)2.95040785
86telomere maintenance via telomere lengthening (GO:0010833)2.94966737
87regulation of NFAT protein import into nucleus (GO:0051532)2.94872023
88nuclear pore complex assembly (GO:0051292)2.94157995
89folic acid metabolic process (GO:0046655)2.93203093
90anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.92593984
91DNA replication checkpoint (GO:0000076)2.92341524
92mitotic nuclear envelope disassembly (GO:0007077)2.91401490
93negative regulation of microtubule polymerization or depolymerization (GO:0031111)2.87803923
94protein localization to synapse (GO:0035418)2.87773738
95NADPH regeneration (GO:0006740)2.86813364
96negative regulation of mRNA metabolic process (GO:1903312)2.86511467
97sister chromatid segregation (GO:0000819)2.86243064
98tRNA aminoacylation for protein translation (GO:0006418)2.86112085
99regulation of mammary gland epithelial cell proliferation (GO:0033599)2.86069447
100maturation of SSU-rRNA (GO:0030490)2.85663271
101negative regulation of RNA splicing (GO:0033119)2.84501652
102pentose metabolic process (GO:0019321)2.82017703
103regulation of synaptic vesicle exocytosis (GO:2000300)2.81732892
104regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.81349121
105maturation of 5.8S rRNA (GO:0000460)2.79774209
106tRNA aminoacylation (GO:0043039)2.79070719
107amino acid activation (GO:0043038)2.79070719
108cellular component biogenesis (GO:0044085)2.78916643
109protein insertion into membrane (GO:0051205)2.78396744
110proteasome assembly (GO:0043248)2.78233592
111neuron cell-cell adhesion (GO:0007158)2.77755429
112negative regulation of ligase activity (GO:0051352)2.76889410
113negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.76889410
114regulation of synapse structural plasticity (GO:0051823)2.76517014
115establishment of viral latency (GO:0019043)2.71682163
116termination of RNA polymerase III transcription (GO:0006386)2.69264391
117transcription elongation from RNA polymerase III promoter (GO:0006385)2.69264391
118locomotory exploration behavior (GO:0035641)2.67519828
119cerebellar Purkinje cell layer development (GO:0021680)2.67407730
120exploration behavior (GO:0035640)2.66825572
121regulation of synapse maturation (GO:0090128)2.66646990
122transcription from mitochondrial promoter (GO:0006390)2.66163338
123establishment of protein localization to mitochondrion (GO:0072655)2.65470169
124regulation of microtubule polymerization (GO:0031113)2.64494335
125regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.64201794
126mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.63236365
127ribonucleoprotein complex biogenesis (GO:0022613)2.63187867
128positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.62289009
129RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.54844018
130tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.54844018
1317-methylguanosine mRNA capping (GO:0006370)2.53844048
132regulation of translational fidelity (GO:0006450)2.53194311
133response to pheromone (GO:0019236)2.53091924
134axonal fasciculation (GO:0007413)2.51264801
135peptidyl-arginine modification (GO:0018195)2.48038392
136positive regulation of ligase activity (GO:0051351)2.46908834
137protein targeting to mitochondrion (GO:0006626)2.46617346
138regulation of cellular amino acid metabolic process (GO:0006521)2.46570601
139neuron recognition (GO:0008038)2.45679193
140neurotransmitter secretion (GO:0007269)2.44834317
141RNA capping (GO:0036260)2.44440950
1427-methylguanosine RNA capping (GO:0009452)2.44440950
143rRNA processing (GO:0006364)2.44324052
144vocalization behavior (GO:0071625)2.43958227
145DNA replication-dependent nucleosome assembly (GO:0006335)2.43181690
146DNA replication-dependent nucleosome organization (GO:0034723)2.43181690
147folic acid-containing compound biosynthetic process (GO:0009396)2.42864892
148viral mRNA export from host cell nucleus (GO:0046784)2.42235237
149synaptic vesicle docking involved in exocytosis (GO:0016081)2.41337815
150DNA unwinding involved in DNA replication (GO:0006268)2.40950269
151spliceosomal complex assembly (GO:0000245)2.40791351
152regulation of synaptic vesicle transport (GO:1902803)2.40252146
153L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.40139061
154protein localization to mitochondrion (GO:0070585)2.39631725
155regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.39054627
156spliceosomal tri-snRNP complex assembly (GO:0000244)2.38672515
157histone H2A acetylation (GO:0043968)2.38241315
158neuromuscular process controlling posture (GO:0050884)2.37613956
159organelle transport along microtubule (GO:0072384)2.36994585
160pseudouridine synthesis (GO:0001522)2.36084488

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse4.01297164
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.83261416
3E2F7_22180533_ChIP-Seq_HELA_Human3.66358462
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.10888250
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.08362514
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.00497257
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.95464097
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.79583559
9* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.61895829
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54064307
11XRN2_22483619_ChIP-Seq_HELA_Human2.51905752
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.51468918
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.46628771
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.36998990
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.33405329
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.32043382
17YY1_21170310_ChIP-Seq_MESCs_Mouse2.20375870
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14655711
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.03465315
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.01453956
21* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.99651382
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.99547309
23* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.94377933
24GABP_19822575_ChIP-Seq_HepG2_Human1.91780853
25NELFA_20434984_ChIP-Seq_ESCs_Mouse1.88400152
26FOXM1_23109430_ChIP-Seq_U2OS_Human1.85485405
27EZH2_22144423_ChIP-Seq_EOC_Human1.85242692
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83430666
29VDR_21846776_ChIP-Seq_THP-1_Human1.83103124
30ZFP281_18757296_ChIP-ChIP_E14_Mouse1.81307229
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80440877
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.79988862
33TTF2_22483619_ChIP-Seq_HELA_Human1.79830319
34* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.77517109
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77388033
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.76393067
37ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.74372424
38DCP1A_22483619_ChIP-Seq_HELA_Human1.73037186
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70883785
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69912903
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69248329
42CIITA_25753668_ChIP-Seq_RAJI_Human1.68495806
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66991827
44CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.66164967
45CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.63421556
46* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58229221
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58099708
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57701553
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.57360157
50* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.56462708
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55297524
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54206550
53KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.53356347
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49738731
55VDR_23849224_ChIP-Seq_CD4+_Human1.47982901
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47599377
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45003592
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43901753
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.43712463
60ZNF263_19887448_ChIP-Seq_K562_Human1.42844871
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.42533110
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41492020
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38728054
64REST_21632747_ChIP-Seq_MESCs_Mouse1.37199240
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36908707
66* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36699155
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.36618200
68NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.36500984
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35422585
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34344780
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34080271
72FOXP3_21729870_ChIP-Seq_TREG_Human1.32309241
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32098308
74LXR_22292898_ChIP-Seq_THP-1_Human1.31417276
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31043939
76MYC_22102868_ChIP-Seq_BL_Human1.29248407
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.29181790
78* SRF_21415370_ChIP-Seq_HL-1_Mouse1.28747595
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28714103
80CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.28392126
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.27035041
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.25377585
83CTCF_18555785_ChIP-Seq_MESCs_Mouse1.24941063
84* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23552730
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23355924
86CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23034430
87FOXP1_21924763_ChIP-Seq_HESCs_Human1.21868156
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21082701
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20504175
90ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20435208
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20145973
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20142787
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19881221
94AR_21909140_ChIP-Seq_LNCAP_Human1.18581411
95YY1_22570637_ChIP-Seq_MALME-3M_Human1.17041258
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16981868
97* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14931066
98HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14817268
99* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.14255417
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13766090
101* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13108067
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12211215
103* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11147821
104KDM5A_27292631_Chip-Seq_BREAST_Human1.10815975
105TFEB_21752829_ChIP-Seq_HELA_Human1.09616760
106CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09080092
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07785895
108OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06824654
109* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06353084
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05746805
111RACK7_27058665_Chip-Seq_MCF-7_Human1.04489214
112RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02314738
113KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02199396
114ERG_21242973_ChIP-ChIP_JURKAT_Human1.01243423
115ELF1_20517297_ChIP-Seq_JURKAT_Human1.00578334
116SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00221652
117SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99426727
118TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99325277
119CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99009947
120TET1_21451524_ChIP-Seq_MESCs_Mouse0.98533731
121SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98179608
122NANOG_21062744_ChIP-ChIP_HESCs_Human0.97782349
123GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96665453
124ZNF274_21170338_ChIP-Seq_K562_Hela0.95762493
125ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95008356
126TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94365448
127SA1_27219007_Chip-Seq_ERYTHROID_Human0.92453532
128EGR1_19374776_ChIP-ChIP_THP-1_Human0.92151984
129MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90314584
130* P68_20966046_ChIP-Seq_HELA_Human0.89565825
131NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88063928
132ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87990908
133* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.86281002
134SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.85828350
135BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85080380

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.54047842
2MP0004270_analgesia2.88514936
3MP0003880_abnormal_central_pattern2.77485688
4MP0005423_abnormal_somatic_nervous2.68360553
5MP0003635_abnormal_synaptic_transmissio2.64581233
6MP0001968_abnormal_touch/_nociception2.58198694
7MP0003123_paternal_imprinting2.46305038
8MP0003122_maternal_imprinting2.43015008
9MP0005451_abnormal_body_composition2.39669033
10MP0006276_abnormal_autonomic_nervous2.27123562
11MP0002063_abnormal_learning/memory/cond2.22795513
12MP0003693_abnormal_embryo_hatching2.18807229
13MP0002735_abnormal_chemical_nociception2.18255521
14MP0002734_abnormal_mechanical_nocicepti2.17345662
15MP0004957_abnormal_blastocyst_morpholog2.16900322
16MP0004858_abnormal_nervous_system2.15499279
17MP0002877_abnormal_melanocyte_morpholog2.14529581
18MP0002733_abnormal_thermal_nociception2.14131514
19MP0003806_abnormal_nucleotide_metabolis2.12817789
20MP0000778_abnormal_nervous_system2.12119424
21MP0002184_abnormal_innervation2.10937642
22MP0003786_premature_aging2.01470820
23MP0003111_abnormal_nucleus_morphology1.99602297
24MP0001529_abnormal_vocalization1.99583748
25MP0003121_genomic_imprinting1.97316812
26MP0002736_abnormal_nociception_after1.94492205
27MP0004811_abnormal_neuron_physiology1.92367679
28MP0009745_abnormal_behavioral_response1.81120168
29MP0008260_abnormal_autophagy1.81116475
30MP0002064_seizures1.78591834
31MP0003705_abnormal_hypodermis_morpholog1.77573035
32MP0000313_abnormal_cell_death1.72513081
33MP0005058_abnormal_lysosome_morphology1.71408121
34MP0002572_abnormal_emotion/affect_behav1.70326183
35MP0004185_abnormal_adipocyte_glucose1.69323376
36MP0001970_abnormal_pain_threshold1.66176254
37MP0001730_embryonic_growth_arrest1.63920485
38MP0010094_abnormal_chromosome_stability1.62294238
39MP0000955_abnormal_spinal_cord1.62231122
40MP0008932_abnormal_embryonic_tissue1.60762752
41MP0006036_abnormal_mitochondrial_physio1.60003043
42MP0005501_abnormal_skin_physiology1.58875786
43MP0001440_abnormal_grooming_behavior1.54341743
44MP0000537_abnormal_urethra_morphology1.54311766
45MP0003077_abnormal_cell_cycle1.52246849
46MP0008058_abnormal_DNA_repair1.51443977
47MP0005394_taste/olfaction_phenotype1.51114351
48MP0005499_abnormal_olfactory_system1.51114351
49MP0004133_heterotaxia1.49986545
50MP0002751_abnormal_autonomic_nervous1.47398045
51MP0003283_abnormal_digestive_organ1.47098740
52MP0004233_abnormal_muscle_weight1.45553756
53MP0003984_embryonic_growth_retardation1.45436476
54MP0003329_amyloid_beta_deposits1.45129138
55MP0001849_ear_inflammation1.45085409
56MP0000490_abnormal_crypts_of1.43254121
57MP0003186_abnormal_redox_activity1.43005897
58MP0002272_abnormal_nervous_system1.41545531
59MP0003718_maternal_effect1.41464967
60MP0000751_myopathy1.41145989
61MP0001661_extended_life_span1.40475599
62MP0005386_behavior/neurological_phenoty1.40158735
63MP0004924_abnormal_behavior1.40158735
64MP0009046_muscle_twitch1.39548646
65MP0003119_abnormal_digestive_system1.38994066
66MP0002822_catalepsy1.38525367
67MP0001905_abnormal_dopamine_level1.35309767
68MP0002088_abnormal_embryonic_growth/wei1.35103719
69MP0008789_abnormal_olfactory_epithelium1.33772638
70MP0000678_abnormal_parathyroid_gland1.32997047
71MP0009333_abnormal_splenocyte_physiolog1.32335439
72MP0002653_abnormal_ependyma_morphology1.31489424
73MP0003861_abnormal_nervous_system1.30065752
74MP0002557_abnormal_social/conspecific_i1.27465784
75MP0006035_abnormal_mitochondrial_morpho1.25690486
76MP0002882_abnormal_neuron_morphology1.23875371
77MP0002152_abnormal_brain_morphology1.23779742
78MP0002396_abnormal_hematopoietic_system1.20513481
79MP0004142_abnormal_muscle_tone1.20108431
80MP0009697_abnormal_copulation1.19467625
81MP0005384_cellular_phenotype1.16070015
82MP0009278_abnormal_bone_marrow1.15082260
83MP0002066_abnormal_motor_capabilities/c1.15074586
84MP0002067_abnormal_sensory_capabilities1.14966922
85MP0008877_abnormal_DNA_methylation1.13530649
86MP0005076_abnormal_cell_differentiation1.12488229
87MP0002019_abnormal_tumor_incidence1.12083955
88MP0000747_muscle_weakness1.11779508
89MP0003221_abnormal_cardiomyocyte_apopto1.11028093
90MP0005621_abnormal_cell_physiology1.09697593
91MP0002638_abnormal_pupillary_reflex1.08397508
92MP0010030_abnormal_orbit_morphology1.07400487
93MP0000350_abnormal_cell_proliferation1.06636978
94MP0002909_abnormal_adrenal_gland1.05291759
95MP0000358_abnormal_cell_content/1.04800767
96MP0002796_impaired_skin_barrier1.04076952
97MP0004145_abnormal_muscle_electrophysio1.03051917
98MP0002086_abnormal_extraembryonic_tissu1.01647866
99MP0002084_abnormal_developmental_patter0.99069271
100MP0005645_abnormal_hypothalamus_physiol0.97923987
101MP0002080_prenatal_lethality0.97711684
102MP0002085_abnormal_embryonic_tissue0.96607693
103MP0004808_abnormal_hematopoietic_stem0.94642256
104MP0001697_abnormal_embryo_size0.94572411
105MP0002089_abnormal_postnatal_growth/wei0.93008577
106MP0002102_abnormal_ear_morphology0.92685462
107MP0003566_abnormal_cell_adhesion0.91986855
108MP0000049_abnormal_middle_ear0.90964939
109MP0002269_muscular_atrophy0.90489773
110MP0001486_abnormal_startle_reflex0.89627493
111MP0008770_decreased_survivor_rate0.87375380
112MP0000750_abnormal_muscle_regeneration0.85985696
113MP0001346_abnormal_lacrimal_gland0.85482525
114MP0010307_abnormal_tumor_latency0.84847464
115MP0002210_abnormal_sex_determination0.83767964
116MP0002752_abnormal_somatic_nervous0.82741551
117MP0000003_abnormal_adipose_tissue0.81583344
118MP0010352_gastrointestinal_tract_polyps0.81050547
119MP0004197_abnormal_fetal_growth/weight/0.80338043
120MP0002249_abnormal_larynx_morphology0.80033858
121MP0005670_abnormal_white_adipose0.79516100
122MP0005330_cardiomyopathy0.78929392
123MP0003787_abnormal_imprinting0.78560424
124MP0002697_abnormal_eye_size0.77723998
125MP0009840_abnormal_foam_cell0.77564554
126MP0000013_abnormal_adipose_tissue0.76342604
127MP0002081_perinatal_lethality0.75686529
128MP0003137_abnormal_impulse_conducting0.75609430
129MP0005380_embryogenesis_phenotype0.72611439
130MP0001672_abnormal_embryogenesis/_devel0.72611439
131MP0001853_heart_inflammation0.72239333
132MP0002111_abnormal_tail_morphology0.72132553
133MP0008007_abnormal_cellular_replicative0.71598563
134MP0002837_dystrophic_cardiac_calcinosis0.71036377
135MP0000759_abnormal_skeletal_muscle0.70539110
136MP0001293_anophthalmia0.70232137
137MP0000703_abnormal_thymus_morphology0.69844087
138MP0005666_abnormal_adipose_tissue0.69349546
139MP0001727_abnormal_embryo_implantation0.69036104
140MP0003938_abnormal_ear_development0.68899763
141MP0003942_abnormal_urinary_system0.68316338
142MP0001348_abnormal_lacrimal_gland0.67733734
143MP0002069_abnormal_eating/drinking_beha0.67689536
144MP0010769_abnormal_survival0.66759389
145MP0000858_altered_metastatic_potential0.66369256
146MP0008057_abnormal_DNA_replication0.66351911
147MP0009672_abnormal_birth_weight0.64912349
148MP0010768_mortality/aging0.64863228
149MP0003315_abnormal_perineum_morphology0.64535386
150MP0005623_abnormal_meninges_morphology0.64097260
151MP0001145_abnormal_male_reproductive0.63542403
152MP0003385_abnormal_body_wall0.63024921
153MP0010770_preweaning_lethality0.62931162
154MP0002092_abnormal_eye_morphology0.62870461
155MP0002060_abnormal_skin_morphology0.62126868
156MP0003656_abnormal_erythrocyte_physiolo0.61951829
157MP0001929_abnormal_gametogenesis0.61637770
158MP0001881_abnormal_mammary_gland0.58757993
159MP0009931_abnormal_skin_appearance0.58230896
160MP0002161_abnormal_fertility/fecundity0.57248763
161MP0000749_muscle_degeneration0.56653261
162MP0002970_abnormal_white_adipose0.56492233

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.09789702
2Cerebral hypomyelination (HP:0006808)4.49673325
3Microvesicular hepatic steatosis (HP:0001414)4.11292913
4Visual hallucinations (HP:0002367)3.86970115
5Progressive muscle weakness (HP:0003323)3.75851641
6Abnormality of the labia minora (HP:0012880)3.69551247
7Ragged-red muscle fibers (HP:0003200)3.58756881
8Multiple enchondromatosis (HP:0005701)3.37494618
9Limb dystonia (HP:0002451)3.22699922
10Delusions (HP:0000746)3.13773373
11Aplasia/Hypoplasia of the sacrum (HP:0008517)3.06811030
12Shoulder girdle muscle weakness (HP:0003547)3.01171368
13Broad distal phalanx of finger (HP:0009836)2.98931405
14Cholecystitis (HP:0001082)2.97463501
15Abnormal gallbladder physiology (HP:0012438)2.97463501
16Atrophy/Degeneration involving motor neurons (HP:0007373)2.92793655
17Mutism (HP:0002300)2.86285132
18Trismus (HP:0000211)2.83819246
19Reticulocytopenia (HP:0001896)2.81582847
20Amyotrophic lateral sclerosis (HP:0007354)2.79751734
21Focal motor seizures (HP:0011153)2.78874051
22Selective tooth agenesis (HP:0001592)2.77438563
23Focal seizures (HP:0007359)2.75913880
24Pheochromocytoma (HP:0002666)2.73469313
25Chromosomal breakage induced by crosslinking agents (HP:0003221)2.69688192
26CNS hypomyelination (HP:0003429)2.69685120
27Hypoplasia of the brainstem (HP:0002365)2.64617013
28Aplasia/Hypoplasia of the brainstem (HP:0007362)2.64617013
29Postnatal microcephaly (HP:0005484)2.61615877
30Abnormal number of erythroid precursors (HP:0012131)2.60230436
31Lissencephaly (HP:0001339)2.59090802
32Increased serum pyruvate (HP:0003542)2.59072877
33Abnormality of glycolysis (HP:0004366)2.59072877
34Abnormality of the anterior horn cell (HP:0006802)2.58963804
35Degeneration of anterior horn cells (HP:0002398)2.58963804
36Pelvic girdle muscle weakness (HP:0003749)2.58589632
37Abnormality of cells of the erythroid lineage (HP:0012130)2.57921209
38Achilles tendon contracture (HP:0001771)2.57410567
39Neuroendocrine neoplasm (HP:0100634)2.55159245
40Abnormality of the lower motor neuron (HP:0002366)2.55019836
41Birth length less than 3rd percentile (HP:0003561)2.52403209
42Urinary urgency (HP:0000012)2.49094019
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.48958919
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.48958919
45Ankle clonus (HP:0011448)2.46661863
46Neoplasm of the peripheral nervous system (HP:0100007)2.44676420
47Abnormality of the hip-girdle musculature (HP:0001445)2.41156563
48Abnormality of the musculature of the pelvis (HP:0001469)2.41156563
49Unsteady gait (HP:0002317)2.38695109
50Type I transferrin isoform profile (HP:0003642)2.37816683
51Abnormality of the umbilical cord (HP:0010881)2.37394801
52Cutaneous melanoma (HP:0012056)2.35189414
53Testicular atrophy (HP:0000029)2.31823865
54Abnormal trabecular bone morphology (HP:0100671)2.31559242
55Insomnia (HP:0100785)2.31454422
56Abnormality of reticulocytes (HP:0004312)2.31307098
57Spastic diplegia (HP:0001264)2.28536356
58Increased serum lactate (HP:0002151)2.28209717
59Polyphagia (HP:0002591)2.27403622
60Impaired pain sensation (HP:0007328)2.26047774
61Abnormality of pain sensation (HP:0010832)2.26047774
62Supranuclear gaze palsy (HP:0000605)2.23915328
63Proximal placement of thumb (HP:0009623)2.19435279
64Chromsome breakage (HP:0040012)2.19315894
65Upper limb muscle weakness (HP:0003484)2.18602299
66Truncus arteriosus (HP:0001660)2.17693993
67Pointed chin (HP:0000307)2.17638116
68Abnormality of the Achilles tendon (HP:0005109)2.16896344
69Hypsarrhythmia (HP:0002521)2.14508503
70Breast hypoplasia (HP:0003187)2.13269828
71Ependymoma (HP:0002888)2.13076238
72Poor suck (HP:0002033)2.12594049
73EEG with generalized epileptiform discharges (HP:0011198)2.12518106
74Secondary amenorrhea (HP:0000869)2.12409848
75Abnormal glycosylation (HP:0012345)2.12341927
76Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12341927
77Abnormal protein N-linked glycosylation (HP:0012347)2.12341927
78Abnormal protein glycosylation (HP:0012346)2.12341927
79Abnormal mitochondria in muscle tissue (HP:0008316)2.12271353
80Upper motor neuron abnormality (HP:0002127)2.12124445
81Poor eye contact (HP:0000817)2.11952968
82Entropion (HP:0000621)2.11553209
83Deviation of the thumb (HP:0009603)2.11511485
84Emotional lability (HP:0000712)2.10085033
85Hypokinesia (HP:0002375)2.09753699
86Cortical dysplasia (HP:0002539)2.09326761
87Upper limb amyotrophy (HP:0009129)2.09218406
88Distal upper limb amyotrophy (HP:0007149)2.09218406
89Astrocytoma (HP:0009592)2.08793158
90Abnormality of the astrocytes (HP:0100707)2.08793158
91Rough bone trabeculation (HP:0100670)2.08375142
92Reticulocytosis (HP:0001923)2.07492270
93Hepatocellular necrosis (HP:0001404)2.06241149
94Morphological abnormality of the pyramidal tract (HP:0002062)2.05971624
95Squamous cell carcinoma (HP:0002860)2.05733309
96Epileptiform EEG discharges (HP:0011182)2.05203717
97Abnormality of the motor neurons (HP:0002450)2.03872273
98Abnormal neuron morphology (HP:0012757)2.03872273
99Epileptic encephalopathy (HP:0200134)2.03790009
100Cholelithiasis (HP:0001081)2.03037627
101Pancytopenia (HP:0001876)2.00170202
102Horseshoe kidney (HP:0000085)1.99065368
103Hypergonadotropic hypogonadism (HP:0000815)1.99016642
104Personality changes (HP:0000751)1.98774281
105Glossoptosis (HP:0000162)1.98720333
106Vertebral compression fractures (HP:0002953)1.98709228
107Patellar aplasia (HP:0006443)1.97351240
108Acute encephalopathy (HP:0006846)1.96352605
109Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96045906
110Lactic acidosis (HP:0003128)1.95800482
111Ureteral duplication (HP:0000073)1.95657807
112Abnormality of the aortic arch (HP:0012303)1.95023130
113Reduced antithrombin III activity (HP:0001976)1.94526896
114Myotonia (HP:0002486)1.93887240
115Amblyopia (HP:0000646)1.93429209
116Distal lower limb amyotrophy (HP:0008944)1.91995324
117Absence seizures (HP:0002121)1.91450720
118Progressive external ophthalmoplegia (HP:0000590)1.90969383
119Failure to thrive in infancy (HP:0001531)1.90805270
120Wrist flexion contracture (HP:0001239)1.90389898
121Long palpebral fissure (HP:0000637)1.89448062
122Overriding aorta (HP:0002623)1.88428944
123Abnormal social behavior (HP:0012433)1.87314286
124Impaired social interactions (HP:0000735)1.87314286
125Abnormality of the preputium (HP:0100587)1.87148849
126Increased intramyocellular lipid droplets (HP:0012240)1.86847831
127Impaired vibration sensation in the lower limbs (HP:0002166)1.84901757
128Fetal akinesia sequence (HP:0001989)1.84696039
129Back pain (HP:0003418)1.82662323
130Exercise intolerance (HP:0003546)1.82481210
131Increased muscle lipid content (HP:0009058)1.81896657
132Aplasia/Hypoplasia of the patella (HP:0006498)1.81240395
133Generalized amyotrophy (HP:0003700)1.81044571
134Athetosis (HP:0002305)1.80803603
135Orthostatic hypotension (HP:0001278)1.80077320
136Centrally nucleated skeletal muscle fibers (HP:0003687)1.80072256
137Muscular hypotonia of the trunk (HP:0008936)1.80006514
138Increased nuchal translucency (HP:0010880)1.79372493
139Atonic seizures (HP:0010819)1.77213442
140Spastic paraparesis (HP:0002313)1.77095296
141Generalized hypotonia (HP:0001290)1.77028259
142Abnormal number of incisors (HP:0011064)1.77025802
143Insidious onset (HP:0003587)1.76274524
144Termporal pattern (HP:0011008)1.76274524
145Hypoventilation (HP:0002791)1.75317290
146Abnormality of the corticospinal tract (HP:0002492)1.74803115
147Adducted thumb (HP:0001181)1.73841484
148Opisthotonus (HP:0002179)1.73687811
149Abnormal umbilical cord blood vessels (HP:0011403)1.73247190
150Single umbilical artery (HP:0001195)1.73247190
151Abnormality of the fetal cardiovascular system (HP:0010948)1.73247190
152Abnormal gallbladder morphology (HP:0012437)1.72816612
153Abnormalities of placenta or umbilical cord (HP:0001194)1.72570148
154Increased CSF lactate (HP:0002490)1.70860522
155Hepatic necrosis (HP:0002605)1.70560672
156Facial cleft (HP:0002006)1.70453456
157External ophthalmoplegia (HP:0000544)1.70126357
158Death in infancy (HP:0001522)1.69722071
159Abnormality of the gallbladder (HP:0005264)1.69564836
160Hyperacusis (HP:0010780)1.69112986
161Hypertensive crisis (HP:0100735)1.68825972
162Hand muscle atrophy (HP:0009130)1.68712221
163Partial agenesis of the corpus callosum (HP:0001338)1.68402266
164Cerebral inclusion bodies (HP:0100314)1.68051252
165Dialeptic seizures (HP:0011146)1.67510000
166Akinesia (HP:0002304)1.66975795
167Acute necrotizing encephalopathy (HP:0006965)1.66674887
168Cerebellar hypoplasia (HP:0001321)1.66589350
169Myopathic facies (HP:0002058)1.66251658
170Cleft eyelid (HP:0000625)1.66225345
171Hypoplasia of the pons (HP:0012110)1.64809856
172Spinal muscular atrophy (HP:0007269)1.61145935
173Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.60698097
174Abnormal eating behavior (HP:0100738)1.60139729
175Sacral dimple (HP:0000960)1.59964194
176Torticollis (HP:0000473)1.59781100
177Glioma (HP:0009733)1.59024217
178Focal dystonia (HP:0004373)1.58948950
179Microretrognathia (HP:0000308)1.58933006
180Premature ovarian failure (HP:0008209)1.58280808
181Intellectual disability, profound (HP:0002187)1.58001033
182Renal duplication (HP:0000075)1.57970933

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.31040173
2SMG13.87829657
3BUB13.61903989
4VRK23.41519633
5MAP3K93.33302577
6MINK12.48822089
7LATS22.45999748
8IRAK32.44644044
9TESK22.32936858
10NEK12.25989258
11KSR12.16995218
12ICK1.96904677
13PAK61.96229999
14WEE11.94144258
15DYRK21.90793676
16CCNB11.90674171
17NTRK31.87078370
18BCKDK1.82904286
19KSR21.81940058
20PNCK1.80369548
21MAP3K41.75464910
22LIMK11.75316122
23SCYL21.75050187
24PASK1.74364081
25PIM21.73759196
26TSSK61.69595132
27ARAF1.67319305
28BRSK11.66188617
29UHMK11.61969483
30PRPF4B1.58454292
31TAOK21.43725573
32KDR1.41841869
33CDK71.40634855
34PBK1.40450859
35CAMKK11.38061786
36ALK1.36450343
37TESK11.31786162
38AURKA1.29758060
39TLK11.28917148
40STK161.27246860
41CDK181.27169248
42CDC71.25981737
43PHKG11.25270576
44PHKG21.25270576
45CDK141.24763655
46CDK151.23252512
47DAPK21.20404891
48MAPK131.19991612
49NME11.19766854
50DAPK11.18457189
51ERN11.17120471
52GRK51.17016345
53MAP3K81.13709644
54CDK11A1.11292239
55EIF2AK11.06173333
56AURKB1.05616758
57CDK191.04695217
58PLK21.03123175
59CDK41.02402886
60TAF11.01603279
61CDK121.00441849
62MAP2K71.00128997
63NTRK10.99813759
64PLK30.99473350
65EPHA40.96939874
66BRAF0.95910769
67MAP3K120.94822349
68ZAK0.93249547
69NME20.92893787
70PRKCG0.92355954
71RAF10.90439997
72CDK50.90078989
73TAOK10.89289195
74ABL20.89019192
75RPS6KA40.87470977
76ILK0.87141405
77RPS6KB20.87065183
78PLK10.86868230
79NTRK20.85693012
80PAK10.83576547
81TTN0.81189838
82CHEK20.80787500
83PRKCI0.80606088
84SIK10.80016954
85PDK20.79954123
86PRKD30.78758260
87PLK40.78204957
88MAP2K40.77884781
89CSNK1A1L0.77679131
90CSNK1G30.77574964
91MAP3K100.77443000
92CSNK1G20.75085864
93CDK80.74894502
94TRIB30.73745977
95STK40.70726715
96AKT20.69189765
97PAK30.68405582
98RPS6KA50.65261806
99DAPK30.64739940
100MAP3K110.62625669
101ACVR1B0.62557878
102ERBB30.61672549
103MAP2K10.61664309
104CSNK1G10.61262515
105PKN20.60721394
106MTOR0.59982005
107DYRK30.59793948
108DYRK1A0.58834179
109EPHA20.58599809
110IRAK20.58049183
111MAP2K30.57796326
112PAK40.56132078
113CSNK1E0.56119534
114WNK30.56055548
115MAPK110.55945321
116SRPK10.55770604
117CHEK10.55654616
118LMTK20.55279707
119PDK40.53789448
120PDK30.53789448
121EEF2K0.52939956
122BRSK20.51711846
123TYRO30.51096974
124RPS6KA20.48460365
125PRKCZ0.48380887
126ATR0.45301956
127CDK20.45220046
128MAP2K20.45056103
129MAPK90.44927420
130PTK20.44693725
131CLK10.43411146
132ATM0.42472157
133NEK20.42179967
134VRK10.42021614
135STK100.41716919
136CSNK2A10.41476377
137BMX0.40948137
138TTK0.39256961
139CSNK2A20.37070174
140CDK10.35702191
141MAPK120.34243919
142CAMKK20.33850830
143ROCK20.31419284

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.45389781
2RNA polymerase_Homo sapiens_hsa030202.92965951
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.82474018
4Synaptic vesicle cycle_Homo sapiens_hsa047212.77636764
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.64689774
6RNA transport_Homo sapiens_hsa030132.48709230
7Spliceosome_Homo sapiens_hsa030402.20020758
8Parkinsons disease_Homo sapiens_hsa050122.15280780
9Ribosome_Homo sapiens_hsa030102.05919776
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.03583215
11DNA replication_Homo sapiens_hsa030301.94090754
12Oxidative phosphorylation_Homo sapiens_hsa001901.89963310
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81735752
14Pentose phosphate pathway_Homo sapiens_hsa000301.80281009
15Oocyte meiosis_Homo sapiens_hsa041141.79788095
16Nicotine addiction_Homo sapiens_hsa050331.72561121
17Pyrimidine metabolism_Homo sapiens_hsa002401.68548516
18Huntingtons disease_Homo sapiens_hsa050161.65307761
19Mismatch repair_Homo sapiens_hsa034301.62318242
20Base excision repair_Homo sapiens_hsa034101.54925794
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51008961
22Folate biosynthesis_Homo sapiens_hsa007901.47758905
23mRNA surveillance pathway_Homo sapiens_hsa030151.47146054
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45979668
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45757267
26Dopaminergic synapse_Homo sapiens_hsa047281.44847571
27Long-term potentiation_Homo sapiens_hsa047201.39557449
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38753835
29Gap junction_Homo sapiens_hsa045401.35336632
30Cell cycle_Homo sapiens_hsa041101.33315995
31Fanconi anemia pathway_Homo sapiens_hsa034601.33272382
32Cardiac muscle contraction_Homo sapiens_hsa042601.30605488
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.29854881
34Alzheimers disease_Homo sapiens_hsa050101.29565557
35Fatty acid elongation_Homo sapiens_hsa000621.28622534
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26749140
37GABAergic synapse_Homo sapiens_hsa047271.24803048
38Olfactory transduction_Homo sapiens_hsa047401.21839386
39Collecting duct acid secretion_Homo sapiens_hsa049661.21395282
40Vitamin B6 metabolism_Homo sapiens_hsa007501.20193735
41Circadian entrainment_Homo sapiens_hsa047131.19608933
42Nucleotide excision repair_Homo sapiens_hsa034201.18933115
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18275404
44Amphetamine addiction_Homo sapiens_hsa050311.18032933
45Vibrio cholerae infection_Homo sapiens_hsa051101.16453609
46Pyruvate metabolism_Homo sapiens_hsa006201.15533124
47Fructose and mannose metabolism_Homo sapiens_hsa000511.14278952
48Galactose metabolism_Homo sapiens_hsa000521.13921963
49Alcoholism_Homo sapiens_hsa050341.13145117
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10428984
51One carbon pool by folate_Homo sapiens_hsa006701.06353008
52Axon guidance_Homo sapiens_hsa043601.05177056
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04479165
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02752593
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01416578
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99335563
57Biosynthesis of amino acids_Homo sapiens_hsa012300.96363896
58Cholinergic synapse_Homo sapiens_hsa047250.95616781
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93963451
60Colorectal cancer_Homo sapiens_hsa052100.91404862
61Purine metabolism_Homo sapiens_hsa002300.89185793
62Cocaine addiction_Homo sapiens_hsa050300.88522238
63Glutamatergic synapse_Homo sapiens_hsa047240.86483087
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84870291
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83470743
66Long-term depression_Homo sapiens_hsa047300.83470253
67Epstein-Barr virus infection_Homo sapiens_hsa051690.82245460
68Morphine addiction_Homo sapiens_hsa050320.80876287
69Non-homologous end-joining_Homo sapiens_hsa034500.79098758
70Systemic lupus erythematosus_Homo sapiens_hsa053220.77907441
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77424785
72Glutathione metabolism_Homo sapiens_hsa004800.77349184
73Glioma_Homo sapiens_hsa052140.77345599
74Selenocompound metabolism_Homo sapiens_hsa004500.77151980
75Oxytocin signaling pathway_Homo sapiens_hsa049210.76202275
76Basal transcription factors_Homo sapiens_hsa030220.75915779
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.71669780
78Insulin secretion_Homo sapiens_hsa049110.70697803
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69398981
80Estrogen signaling pathway_Homo sapiens_hsa049150.69164350
81Serotonergic synapse_Homo sapiens_hsa047260.68443335
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.68111567
83Arginine and proline metabolism_Homo sapiens_hsa003300.67212995
84mTOR signaling pathway_Homo sapiens_hsa041500.65968280
85p53 signaling pathway_Homo sapiens_hsa041150.65669585
86GnRH signaling pathway_Homo sapiens_hsa049120.65522204
87Melanogenesis_Homo sapiens_hsa049160.64957841
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.64509118
89Hedgehog signaling pathway_Homo sapiens_hsa043400.62928790
90Hippo signaling pathway_Homo sapiens_hsa043900.62300555
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61808456
92RNA degradation_Homo sapiens_hsa030180.61085721
93Chronic myeloid leukemia_Homo sapiens_hsa052200.59736536
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.59293326
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58784765
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57781910
97Carbon metabolism_Homo sapiens_hsa012000.56886718
98N-Glycan biosynthesis_Homo sapiens_hsa005100.56836755
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56077690
100Shigellosis_Homo sapiens_hsa051310.55302550
101Steroid biosynthesis_Homo sapiens_hsa001000.55001921
102Sulfur metabolism_Homo sapiens_hsa009200.54794864
103Metabolic pathways_Homo sapiens_hsa011000.54788717
104Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54232549
105ErbB signaling pathway_Homo sapiens_hsa040120.54103632
106Phenylalanine metabolism_Homo sapiens_hsa003600.53742015
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53107609
108Salivary secretion_Homo sapiens_hsa049700.52889906
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52206715
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52058981
111Renal cell carcinoma_Homo sapiens_hsa052110.50736575
112Homologous recombination_Homo sapiens_hsa034400.50701527
113Bladder cancer_Homo sapiens_hsa052190.50454453
114Taste transduction_Homo sapiens_hsa047420.49565776
115Endometrial cancer_Homo sapiens_hsa052130.47928753
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47907227
117Acute myeloid leukemia_Homo sapiens_hsa052210.45714969
118Prion diseases_Homo sapiens_hsa050200.45484583
119Wnt signaling pathway_Homo sapiens_hsa043100.44470533
120Thyroid cancer_Homo sapiens_hsa052160.43239796
121Other glycan degradation_Homo sapiens_hsa005110.43011136
122VEGF signaling pathway_Homo sapiens_hsa043700.42518960
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.42471889
124HTLV-I infection_Homo sapiens_hsa051660.41838951
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40342200
126Gastric acid secretion_Homo sapiens_hsa049710.40161310
127Lysine degradation_Homo sapiens_hsa003100.39879283
128Apoptosis_Homo sapiens_hsa042100.39075122
129Sulfur relay system_Homo sapiens_hsa041220.38347067
130Arginine biosynthesis_Homo sapiens_hsa002200.38194857
131Insulin signaling pathway_Homo sapiens_hsa049100.36078049
132Calcium signaling pathway_Homo sapiens_hsa040200.35421295
133Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35355351
134Viral carcinogenesis_Homo sapiens_hsa052030.35288145
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35087361
136Fatty acid metabolism_Homo sapiens_hsa012120.34685710
137Non-small cell lung cancer_Homo sapiens_hsa052230.33453897
138Basal cell carcinoma_Homo sapiens_hsa052170.33214182
139HIF-1 signaling pathway_Homo sapiens_hsa040660.33174486
140Pancreatic cancer_Homo sapiens_hsa052120.32315451
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29202978
142Herpes simplex infection_Homo sapiens_hsa051680.23258863
143Tyrosine metabolism_Homo sapiens_hsa003500.23027728
144Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22246370
145Small cell lung cancer_Homo sapiens_hsa052220.21694454
146Hepatitis B_Homo sapiens_hsa051610.18277838
147Glycosaminoglycan degradation_Homo sapiens_hsa005310.18260772
148AMPK signaling pathway_Homo sapiens_hsa041520.17625162

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