ARMC8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)6.19258274
2vocalization behavior (GO:0071625)5.37385612
3synaptic vesicle exocytosis (GO:0016079)5.25937065
4neuron cell-cell adhesion (GO:0007158)5.24175846
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.22627663
6DNA double-strand break processing (GO:0000729)5.09972108
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.06797915
8piRNA metabolic process (GO:0034587)5.05081165
9protein K11-linked deubiquitination (GO:0035871)5.02134853
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.96678580
11protein localization to synapse (GO:0035418)4.84434451
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.84152435
13regulation of synaptic vesicle exocytosis (GO:2000300)4.79463990
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.75503531
15regulation of glutamate receptor signaling pathway (GO:1900449)4.70504735
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.67303364
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.58157256
18retinal cone cell development (GO:0046549)4.55546380
19glutamate secretion (GO:0014047)4.53648350
20glutamate receptor signaling pathway (GO:0007215)4.36441118
21regulation of synaptic vesicle transport (GO:1902803)4.33058109
22DNA methylation involved in gamete generation (GO:0043046)4.26567221
23neurotransmitter-gated ion channel clustering (GO:0072578)4.26164547
24neuron-neuron synaptic transmission (GO:0007270)4.21548408
25synaptic transmission, glutamatergic (GO:0035249)4.18511931
26male meiosis (GO:0007140)4.12175449
27male meiosis I (GO:0007141)4.08595288
28synaptic vesicle maturation (GO:0016188)4.06156191
29presynaptic membrane assembly (GO:0097105)4.05059742
30positive regulation of synapse maturation (GO:0090129)3.98192726
31neurotransmitter secretion (GO:0007269)3.97050030
32neuronal action potential propagation (GO:0019227)3.95271173
33locomotory exploration behavior (GO:0035641)3.94577195
34resolution of meiotic recombination intermediates (GO:0000712)3.93254656
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.85566759
36gamma-aminobutyric acid signaling pathway (GO:0007214)3.81607116
37regulation of meiosis I (GO:0060631)3.80857930
38postsynaptic membrane organization (GO:0001941)3.79760142
39negative regulation of synaptic transmission, GABAergic (GO:0032229)3.77767278
40chromosome organization involved in meiosis (GO:0070192)3.75648903
41response to histamine (GO:0034776)3.74673327
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.74186995
43protein neddylation (GO:0045116)3.73624594
44long-term synaptic potentiation (GO:0060291)3.71304842
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.66460210
46centriole replication (GO:0007099)3.65627399
47presynaptic membrane organization (GO:0097090)3.61193523
48regulation of long-term neuronal synaptic plasticity (GO:0048169)3.61082317
49meiosis I (GO:0007127)3.59660215
50negative regulation of DNA-dependent DNA replication (GO:2000104)3.59434762
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.58432656
52exploration behavior (GO:0035640)3.57824320
53neuron recognition (GO:0008038)3.57542195
54replication fork processing (GO:0031297)3.54718077
55regulation of postsynaptic membrane potential (GO:0060078)3.53928854
56synaptic vesicle endocytosis (GO:0048488)3.48059903
57negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.47624128
58regulation of synaptic transmission, glutamatergic (GO:0051966)3.46115094
59reciprocal DNA recombination (GO:0035825)3.44862657
60reciprocal meiotic recombination (GO:0007131)3.44862657
61RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.43714327
62regulation of neuronal synaptic plasticity (GO:0048168)3.39445988
63regulation of synapse structural plasticity (GO:0051823)3.37896463
64regulation of synapse maturation (GO:0090128)3.36244333
65positive regulation of membrane potential (GO:0045838)3.35494359
66CENP-A containing nucleosome assembly (GO:0034080)3.35213752
67chromatin remodeling at centromere (GO:0031055)3.32534321
68DNA catabolic process, exonucleolytic (GO:0000738)3.31718763
69long-term memory (GO:0007616)3.30798541
70vesicle transport along microtubule (GO:0047496)3.25803447
71positive regulation of neurotransmitter secretion (GO:0001956)3.24133185
72histone exchange (GO:0043486)3.23573515
73neurotransmitter transport (GO:0006836)3.23450286
74regulation of neurotransmitter secretion (GO:0046928)3.23149914
75positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.22792528
76regulation of synaptic plasticity (GO:0048167)3.21622705
77axonal fasciculation (GO:0007413)3.17483567
78regulation of vesicle fusion (GO:0031338)3.16641309
79regulation of mitotic spindle checkpoint (GO:1903504)3.16621410
80regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.16621410
81striatum development (GO:0021756)3.16554473
82synapse assembly (GO:0007416)3.15913880
83cerebellar Purkinje cell differentiation (GO:0021702)3.15527722
84membrane depolarization during action potential (GO:0086010)3.13943124
85response to pheromone (GO:0019236)3.13862443
86neural tube formation (GO:0001841)3.13624958
87attachment of spindle microtubules to kinetochore (GO:0008608)3.12701226
88positive regulation of synapse assembly (GO:0051965)3.10618639
89positive regulation of neurotransmitter transport (GO:0051590)3.09941289
90transmission of nerve impulse (GO:0019226)3.09591750
91negative regulation of dendrite morphogenesis (GO:0050774)3.08696507
92meiotic nuclear division (GO:0007126)3.07805620
93membrane depolarization (GO:0051899)3.05527638
94layer formation in cerebral cortex (GO:0021819)3.04663774
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.03585846
96cerebellar granule cell differentiation (GO:0021707)3.03084812
97startle response (GO:0001964)3.02277442
98behavioral defense response (GO:0002209)3.01237344
99behavioral fear response (GO:0001662)3.01237344
100negative regulation of DNA recombination (GO:0045910)3.00861972
101regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.00105449
102gamma-aminobutyric acid transport (GO:0015812)2.99290252
103regulation of neurotransmitter transport (GO:0051588)2.99179284
104positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.98794991
105regulation of neurotransmitter levels (GO:0001505)2.97173197
106synaptic vesicle transport (GO:0048489)2.96727213
107establishment of synaptic vesicle localization (GO:0097480)2.96727213
108negative regulation of dendrite development (GO:2000171)2.96547987
109innervation (GO:0060384)2.96525839
110positive regulation of synaptic transmission, GABAergic (GO:0032230)2.95971829
111detection of calcium ion (GO:0005513)2.94945769
112regulation of DNA endoreduplication (GO:0032875)2.94422903
113synaptic transmission (GO:0007268)2.94136932
114double-strand break repair via homologous recombination (GO:0000724)2.93105685
115recombinational repair (GO:0000725)2.92863395
116membrane hyperpolarization (GO:0060081)2.92747760
117meiotic chromosome segregation (GO:0045132)2.91304445
118establishment of vesicle localization (GO:0051650)2.90660240
119cullin deneddylation (GO:0010388)2.89988241
120learning (GO:0007612)2.89820014
121mitotic spindle checkpoint (GO:0071174)2.89649667
122histone mRNA catabolic process (GO:0071044)2.89325007
123dendrite development (GO:0016358)2.89272241
124organelle transport along microtubule (GO:0072384)2.88531479
125gene silencing by RNA (GO:0031047)2.88518703
126regulation of cilium movement (GO:0003352)2.88443942
127microtubule depolymerization (GO:0007019)2.88188171
128histone H2A acetylation (GO:0043968)2.88012077
129serotonin receptor signaling pathway (GO:0007210)2.87238392
130protein K6-linked ubiquitination (GO:0085020)2.86928297
131adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.86891514
132neuromuscular synaptic transmission (GO:0007274)2.86856059
133protein K63-linked deubiquitination (GO:0070536)2.86095801
134meiotic cell cycle process (GO:1903046)2.85328368
135behavioral response to cocaine (GO:0048148)2.84857319
136microtubule anchoring (GO:0034453)2.84836716
137fear response (GO:0042596)2.84442843
138intraspecies interaction between organisms (GO:0051703)2.84147543
139social behavior (GO:0035176)2.84147543
140spindle checkpoint (GO:0031577)2.83102966
141regulation of respiratory system process (GO:0044065)2.82553182
142cellular potassium ion homeostasis (GO:0030007)2.81009702
143positive regulation of synaptic transmission (GO:0050806)2.80948180
144proteasome assembly (GO:0043248)2.76938970
145regulation of histone H3-K9 methylation (GO:0051570)2.76267560
146non-recombinational repair (GO:0000726)2.76154229
147double-strand break repair via nonhomologous end joining (GO:0006303)2.76154229
148regulation of synapse assembly (GO:0051963)2.75541570
149regulation of dendritic spine morphogenesis (GO:0061001)2.75196171
150mechanosensory behavior (GO:0007638)2.74861055
151detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.72010220
152negative regulation of mitotic sister chromatid separation (GO:2000816)2.69587502
153negative regulation of sister chromatid segregation (GO:0033046)2.69587502
154negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.69587502
155negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.69587502
156negative regulation of mitotic sister chromatid segregation (GO:0033048)2.69587502
157protein deneddylation (GO:0000338)2.68844256
158histone mRNA metabolic process (GO:0008334)2.63637509
159regulation of centriole replication (GO:0046599)2.62089065
160regulation of double-strand break repair via homologous recombination (GO:0010569)2.61534614
161retinal rod cell development (GO:0046548)2.60466723
162mitotic spindle assembly checkpoint (GO:0007094)2.60089604
163regulation of sarcomere organization (GO:0060297)2.60026587
164somatic hypermutation of immunoglobulin genes (GO:0016446)2.59358113
165somatic diversification of immune receptors via somatic mutation (GO:0002566)2.59358113
166negative regulation of chromosome segregation (GO:0051985)2.57559666
167somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.57513616
168somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.57513616
169isotype switching (GO:0045190)2.57513616
170regulation of acyl-CoA biosynthetic process (GO:0050812)2.56918192
171spindle assembly checkpoint (GO:0071173)2.54668661
172regulation of mitotic sister chromatid separation (GO:0010965)2.54455080
173regulation of mitotic sister chromatid segregation (GO:0033047)2.54455080
174regulation of sister chromatid segregation (GO:0033045)2.54455080
175maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.53856809
176nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.52769547
177DNA replication-dependent nucleosome organization (GO:0034723)2.52318755
178DNA replication-dependent nucleosome assembly (GO:0006335)2.52318755
179kinetochore organization (GO:0051383)2.51857608
180sister chromatid cohesion (GO:0007062)2.51067183
181regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.50586888
182regulation of mitotic metaphase/anaphase transition (GO:0030071)2.50586888
183DNA deamination (GO:0045006)2.50070200
184establishment of protein localization to Golgi (GO:0072600)2.49191999
185rRNA catabolic process (GO:0016075)2.48426959
186meiotic cell cycle (GO:0051321)2.46812005
187DNA synthesis involved in DNA repair (GO:0000731)2.44963985
188exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.43878492
189adenosine metabolic process (GO:0046085)2.43738484
190protein K11-linked ubiquitination (GO:0070979)2.43191419
191double-strand break repair (GO:0006302)2.42843478
192negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.41959483
193postreplication repair (GO:0006301)2.39613689
194protein sumoylation (GO:0016925)2.38289676
195protein polyglutamylation (GO:0018095)2.37810586
196mitotic sister chromatid cohesion (GO:0007064)2.37614344
197DNA replication-independent nucleosome assembly (GO:0006336)2.36487726
198DNA replication-independent nucleosome organization (GO:0034724)2.36487726
199microtubule polymerization or depolymerization (GO:0031109)2.36473953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.92014954
2GBX2_23144817_ChIP-Seq_PC3_Human4.49606728
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.83184805
4REST_21632747_ChIP-Seq_MESCs_Mouse2.82820583
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.69565383
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63751741
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.61781744
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.48018643
9TAF15_26573619_Chip-Seq_HEK293_Human2.41662964
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36393765
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.35155592
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.29113197
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29056764
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.24912935
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.23187434
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.23058376
17* REST_18959480_ChIP-ChIP_MESCs_Mouse2.22144100
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21893181
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.21307444
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.20649340
21FUS_26573619_Chip-Seq_HEK293_Human2.18874419
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.18072581
23P300_19829295_ChIP-Seq_ESCs_Human2.10209186
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09881894
25* SMAD_19615063_ChIP-ChIP_OVARY_Human2.08792201
26SMAD4_21799915_ChIP-Seq_A2780_Human2.06253014
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03360017
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.02124843
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.95703530
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.95423448
31ELK1_19687146_ChIP-ChIP_HELA_Human1.92798806
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.91378622
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.90722952
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88801365
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87780676
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86010449
37DROSHA_22980978_ChIP-Seq_HELA_Human1.83093905
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81361164
39ZNF274_21170338_ChIP-Seq_K562_Hela1.80923835
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79967390
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78987309
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78293923
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77886374
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.76173917
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.76173917
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.73986707
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.73788096
48IGF1R_20145208_ChIP-Seq_DFB_Human1.69227739
49VDR_22108803_ChIP-Seq_LS180_Human1.64400584
50* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63916689
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.63052531
52AR_21572438_ChIP-Seq_LNCaP_Human1.62162245
53* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58400346
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57277131
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56725431
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.56328495
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.56245158
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53893357
59VDR_23849224_ChIP-Seq_CD4+_Human1.51316278
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.50811126
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.50588166
62AR_25329375_ChIP-Seq_VCAP_Human1.49431908
63STAT3_23295773_ChIP-Seq_U87_Human1.48811151
64EZH2_27294783_Chip-Seq_ESCs_Mouse1.48377959
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47258010
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46845063
67EWS_26573619_Chip-Seq_HEK293_Human1.45713853
68* RNF2_27304074_Chip-Seq_NSC_Mouse1.44223169
69SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43917845
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.42470911
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40979494
72TCF4_23295773_ChIP-Seq_U87_Human1.39554792
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38816726
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.38249533
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37610961
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.35143745
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35111545
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.34204383
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33504041
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32492286
81IRF1_19129219_ChIP-ChIP_H3396_Human1.32383150
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32122037
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.30869909
84TP53_22573176_ChIP-Seq_HFKS_Human1.30331551
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.29944967
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29834638
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29633213
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29090215
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.28562842
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28041554
91FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27637492
92ER_23166858_ChIP-Seq_MCF-7_Human1.27050299
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25870424
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.25427749
95E2F7_22180533_ChIP-Seq_HELA_Human1.25309894
96* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24319425
97POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24128455
98FLI1_21867929_ChIP-Seq_TH2_Mouse1.23465178
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23206265
100IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22798335
101JUN_21703547_ChIP-Seq_K562_Human1.21652710
102SOX2_19829295_ChIP-Seq_ESCs_Human1.21046957
103NANOG_19829295_ChIP-Seq_ESCs_Human1.21046957
104* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20008883
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.19531154
106OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19413885
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18469104
108FOXP3_21729870_ChIP-Seq_TREG_Human1.18069016
109MYC_18940864_ChIP-ChIP_HL60_Human1.17809269
110NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.17606865
111RUNX2_22187159_ChIP-Seq_PCA_Human1.17160171
112YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17145138
113SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.15803144
114NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14983232
115BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14185448
116E2F1_18555785_Chip-Seq_ESCs_Mouse1.13186146
117FLI1_27457419_Chip-Seq_LIVER_Mouse1.13056488
118SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12770319
119SOX9_26525672_Chip-Seq_HEART_Mouse1.11725067
120TCF4_22108803_ChIP-Seq_LS180_Human1.11255943
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10510812
122FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10124780
123STAT3_18555785_Chip-Seq_ESCs_Mouse1.09850760
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09767151
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09767151
126P300_18555785_Chip-Seq_ESCs_Mouse1.09399764
127AR_19668381_ChIP-Seq_PC3_Human1.08882887
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08546924
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08394926
130FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07943532
131EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07460359
132TAL1_26923725_Chip-Seq_HPCs_Mouse1.05632035
133CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05430719
134RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05297578
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04449491
136CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03992701
137OCT4_18555785_Chip-Seq_ESCs_Mouse1.03180231
138BCAT_22108803_ChIP-Seq_LS180_Human1.03092577
139CBP_20019798_ChIP-Seq_JUKART_Human1.02164800
140IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02164800
141CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01841193
142CMYC_18555785_Chip-Seq_ESCs_Mouse1.01498996
143RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01485261
144* SMAD3_21741376_ChIP-Seq_ESCs_Human0.99597064
145GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98574728
146* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97159980
147RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96938020
148MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96674729
149P53_22387025_ChIP-Seq_ESCs_Mouse0.96376044

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.08910246
2MP0003880_abnormal_central_pattern5.04979154
3MP0003635_abnormal_synaptic_transmissio3.71701235
4MP0001968_abnormal_touch/_nociception3.48580630
5MP0008058_abnormal_DNA_repair3.26770642
6MP0004270_analgesia3.18313334
7MP0009745_abnormal_behavioral_response3.15692471
8MP0002063_abnormal_learning/memory/cond3.09167353
9MP0008057_abnormal_DNA_replication3.01367965
10MP0002736_abnormal_nociception_after2.99870125
11MP0009046_muscle_twitch2.82115778
12MP0002064_seizures2.82001581
13MP0002102_abnormal_ear_morphology2.78002956
14MP0003718_maternal_effect2.71373589
15MP0002572_abnormal_emotion/affect_behav2.70304476
16MP0005423_abnormal_somatic_nervous2.61357265
17MP0002735_abnormal_chemical_nociception2.56111890
18MP0002734_abnormal_mechanical_nocicepti2.47508232
19MP0002272_abnormal_nervous_system2.45473020
20MP0001984_abnormal_olfaction2.39933141
21MP0001501_abnormal_sleep_pattern2.37698033
22MP0010094_abnormal_chromosome_stability2.30255706
23MP0001188_hyperpigmentation2.27443043
24MP0006276_abnormal_autonomic_nervous2.20754184
25MP0002067_abnormal_sensory_capabilities2.16661388
26MP0001486_abnormal_startle_reflex2.15398769
27MP0002822_catalepsy2.13519338
28MP0004147_increased_porphyrin_level2.08367708
29MP0001440_abnormal_grooming_behavior2.03619725
30MP0000372_irregular_coat_pigmentation1.98334263
31MP0002184_abnormal_innervation1.94754802
32MP0005646_abnormal_pituitary_gland1.94269485
33MP0001529_abnormal_vocalization1.93256794
34MP0003787_abnormal_imprinting1.85740479
35MP0004924_abnormal_behavior1.85622372
36MP0005386_behavior/neurological_phenoty1.85622372
37MP0002733_abnormal_thermal_nociception1.83058217
38MP0008877_abnormal_DNA_methylation1.78264703
39MP0001970_abnormal_pain_threshold1.75049693
40MP0002557_abnormal_social/conspecific_i1.74319471
41MP0000778_abnormal_nervous_system1.72335490
42MP0000569_abnormal_digit_pigmentation1.72143968
43MP0003786_premature_aging1.67160839
44MP0004811_abnormal_neuron_physiology1.61738287
45MP0002638_abnormal_pupillary_reflex1.60296145
46MP0009697_abnormal_copulation1.58936122
47MP0001929_abnormal_gametogenesis1.57050951
48MP0005645_abnormal_hypothalamus_physiol1.56969862
49MP0008569_lethality_at_weaning1.56911932
50MP0000465_gastrointestinal_hemorrhage1.56041036
51MP0002234_abnormal_pharynx_morphology1.55912629
52MP0005075_abnormal_melanosome_morpholog1.52241564
53MP0008995_early_reproductive_senescence1.51669568
54MP0002909_abnormal_adrenal_gland1.48974351
55MP0002210_abnormal_sex_determination1.48710908
56MP0006292_abnormal_olfactory_placode1.44334069
57MP0005187_abnormal_penis_morphology1.44302477
58MP0003122_maternal_imprinting1.43358167
59MP0003879_abnormal_hair_cell1.42512909
60MP0009780_abnormal_chondrocyte_physiolo1.42317705
61MP0002837_dystrophic_cardiac_calcinosis1.41737359
62MP0001986_abnormal_taste_sensitivity1.41717101
63MP0000427_abnormal_hair_cycle1.40999648
64MP0002160_abnormal_reproductive_system1.40496096
65MP0005389_reproductive_system_phenotype1.39104913
66MP0005084_abnormal_gallbladder_morpholo1.36323987
67MP0001502_abnormal_circadian_rhythm1.36098587
68MP0005551_abnormal_eye_electrophysiolog1.36064946
69MP0001905_abnormal_dopamine_level1.33688364
70MP0000653_abnormal_sex_gland1.32871054
71MP0003698_abnormal_male_reproductive1.31058579
72MP0002882_abnormal_neuron_morphology1.30880626
73MP0003646_muscle_fatigue1.30004217
74MP0005499_abnormal_olfactory_system1.29645566
75MP0005394_taste/olfaction_phenotype1.29645566
76MP0006036_abnormal_mitochondrial_physio1.29425891
77MP0003111_abnormal_nucleus_morphology1.29286330
78MP0000955_abnormal_spinal_cord1.28505402
79MP0002066_abnormal_motor_capabilities/c1.27268329
80MP0003693_abnormal_embryo_hatching1.26834813
81MP0000383_abnormal_hair_follicle1.25417346
82MP0010386_abnormal_urinary_bladder1.21655928
83MP0004142_abnormal_muscle_tone1.21517455
84MP0003183_abnormal_peptide_metabolism1.20605069
85MP0001145_abnormal_male_reproductive1.17993167
86MP0004957_abnormal_blastocyst_morpholog1.17061584
87MP0003950_abnormal_plasma_membrane1.13748481
88MP0003121_genomic_imprinting1.13292298
89MP0008007_abnormal_cellular_replicative1.12750996
90MP0005464_abnormal_platelet_physiology1.12410517
91MP0000647_abnormal_sebaceous_gland1.11663399
92MP0002095_abnormal_skin_pigmentation1.11599875
93MP0003656_abnormal_erythrocyte_physiolo1.09237927
94MP0003077_abnormal_cell_cycle1.09204818
95MP0002152_abnormal_brain_morphology1.05707116
96MP0004215_abnormal_myocardial_fiber1.04555679
97MP0001919_abnormal_reproductive_system1.03308210
98MP0003806_abnormal_nucleotide_metabolis1.03255687
99MP0003633_abnormal_nervous_system1.03038099
100MP0003724_increased_susceptibility_to0.99330841
101MP0000631_abnormal_neuroendocrine_gland0.99234225
102MP0004858_abnormal_nervous_system0.98079046
103MP0001119_abnormal_female_reproductive0.97793052
104MP0003136_yellow_coat_color0.95256011
105MP0003329_amyloid_beta_deposits0.93711499
106MP0003631_nervous_system_phenotype0.93061353
107MP0004742_abnormal_vestibular_system0.92672375
108MP0003567_abnormal_fetal_cardiomyocyte0.92350620
109MP0002229_neurodegeneration0.91613802
110MP0004145_abnormal_muscle_electrophysio0.90357888
111MP0005395_other_phenotype0.88905992
112MP0003195_calcinosis0.88244444
113MP0006072_abnormal_retinal_apoptosis0.87836409
114MP0008872_abnormal_physiological_respon0.87636298
115MP0005310_abnormal_salivary_gland0.85848245
116MP0004233_abnormal_muscle_weight0.85745598
117MP0004885_abnormal_endolymph0.83752687
118MP0004084_abnormal_cardiac_muscle0.83629854
119MP0000013_abnormal_adipose_tissue0.82842814
120MP0005409_darkened_coat_color0.82562272
121MP0000751_myopathy0.82119329
122MP0000015_abnormal_ear_pigmentation0.81852543
123MP0002069_abnormal_eating/drinking_beha0.80640023
124MP0002752_abnormal_somatic_nervous0.79901151
125MP0001963_abnormal_hearing_physiology0.79181419
126MP0005253_abnormal_eye_physiology0.78537433
127MP0004085_abnormal_heartbeat0.78082869
128MP0005410_abnormal_fertilization0.76782119
129MP0009703_decreased_birth_body0.75685742
130MP0003123_paternal_imprinting0.74531609
131MP0004484_altered_response_of0.69801842
132MP0002751_abnormal_autonomic_nervous0.67819409
133MP0008789_abnormal_olfactory_epithelium0.67787240
134MP0002876_abnormal_thyroid_physiology0.67394470
135MP0008004_abnormal_stomach_pH0.65847310
136MP0001485_abnormal_pinna_reflex0.65700863
137MP0008775_abnormal_heart_ventricle0.64779441
138MP0003861_abnormal_nervous_system0.64498430
139MP0003632_abnormal_nervous_system0.63671045
140MP0000230_abnormal_systemic_arterial0.63312700
141MP0004036_abnormal_muscle_relaxation0.63115778
142MP0005535_abnormal_body_temperature0.62002497
143MP0003890_abnormal_embryonic-extraembry0.61849794
144MP0005379_endocrine/exocrine_gland_phen0.59438861
145MP0001664_abnormal_digestion0.57063043
146MP0008874_decreased_physiological_sensi0.56664612
147MP0006035_abnormal_mitochondrial_morpho0.55776275
148MP0002090_abnormal_vision0.54579095
149MP0010770_preweaning_lethality0.54287925
150MP0002082_postnatal_lethality0.54287925
151MP0004043_abnormal_pH_regulation0.54092024

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.59798366
2Epileptic encephalopathy (HP:0200134)5.14071348
3Focal seizures (HP:0007359)4.95256954
4Febrile seizures (HP:0002373)4.80404114
5Atonic seizures (HP:0010819)4.74236534
6Visual hallucinations (HP:0002367)4.65658747
7Hyperventilation (HP:0002883)4.12638719
8Absence seizures (HP:0002121)4.12586896
9Myokymia (HP:0002411)3.99313188
10Abnormal hair whorl (HP:0010721)3.93670014
11Broad-based gait (HP:0002136)3.78192830
12Dialeptic seizures (HP:0011146)3.73735375
13Generalized tonic-clonic seizures (HP:0002069)3.38374712
14Progressive cerebellar ataxia (HP:0002073)3.36844649
15Protruding tongue (HP:0010808)3.22542055
16Pancreatic cysts (HP:0001737)3.22139485
17Gaze-evoked nystagmus (HP:0000640)3.12694056
18Poor eye contact (HP:0000817)2.97708588
19Pancreatic fibrosis (HP:0100732)2.94809096
20True hermaphroditism (HP:0010459)2.88984844
21Absent speech (HP:0001344)2.77963549
22Truncal ataxia (HP:0002078)2.73578846
23Excessive salivation (HP:0003781)2.71910792
24Drooling (HP:0002307)2.71910792
25Renal cortical cysts (HP:0000803)2.69929323
26Gonadotropin excess (HP:0000837)2.66431719
27Gait imbalance (HP:0002141)2.64881105
28Epileptiform EEG discharges (HP:0011182)2.64204160
29Impaired vibration sensation in the lower limbs (HP:0002166)2.63520438
30Abnormality of the renal cortex (HP:0011035)2.62144069
31Impaired social interactions (HP:0000735)2.61273970
32Abnormal social behavior (HP:0012433)2.61273970
33Nephronophthisis (HP:0000090)2.58134901
34Fair hair (HP:0002286)2.53673863
35Oligodactyly (hands) (HP:0001180)2.53083205
36Intestinal atresia (HP:0011100)2.51109002
37Impaired smooth pursuit (HP:0007772)2.49527382
38Progressive inability to walk (HP:0002505)2.49247587
39Pheochromocytoma (HP:0002666)2.47331580
40Amblyopia (HP:0000646)2.45981871
41Colon cancer (HP:0003003)2.44702214
42Limb dystonia (HP:0002451)2.44695175
43EEG with generalized epileptiform discharges (HP:0011198)2.42794133
44Abnormality of chromosome stability (HP:0003220)2.42128192
45Inability to walk (HP:0002540)2.41093334
46Medial flaring of the eyebrow (HP:0010747)2.38375762
47Generalized hypopigmentation of hair (HP:0011358)2.36213536
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.35759104
49Congenital primary aphakia (HP:0007707)2.31956410
50Hyperglycinemia (HP:0002154)2.30459681
51Shoulder girdle muscle weakness (HP:0003547)2.26012724
52Nephrogenic diabetes insipidus (HP:0009806)2.25253560
53Abnormality of the renal medulla (HP:0100957)2.25056691
54Methylmalonic acidemia (HP:0002912)2.24158971
55Stereotypic behavior (HP:0000733)2.24096582
56Action tremor (HP:0002345)2.23836237
57Abolished electroretinogram (ERG) (HP:0000550)2.23593797
58Depression (HP:0000716)2.22767942
59Hypsarrhythmia (HP:0002521)2.21631322
60Dysdiadochokinesis (HP:0002075)2.20580903
61Abnormality of ocular smooth pursuit (HP:0000617)2.19217418
62Neuroendocrine neoplasm (HP:0100634)2.19058411
63Stomach cancer (HP:0012126)2.18552365
64Polyphagia (HP:0002591)2.17827648
65Papillary thyroid carcinoma (HP:0002895)2.16328165
66Aplasia/Hypoplasia of the tibia (HP:0005772)2.16023594
67Abnormal eating behavior (HP:0100738)2.15844744
68Abnormality of the labia minora (HP:0012880)2.15536299
69Attenuation of retinal blood vessels (HP:0007843)2.15227540
70Anxiety (HP:0000739)2.14231351
71Gastroesophageal reflux (HP:0002020)2.13586120
72Small intestinal stenosis (HP:0012848)2.12136388
73Duodenal stenosis (HP:0100867)2.12136388
74Dyschromatopsia (HP:0007641)2.11053299
75Blue irides (HP:0000635)2.10052567
76Abnormal biliary tract physiology (HP:0012439)2.09100127
77Bile duct proliferation (HP:0001408)2.09100127
78Abnormality of the ileum (HP:0001549)2.08786104
79Fetal akinesia sequence (HP:0001989)2.07964146
80Abnormality of the heme biosynthetic pathway (HP:0010472)2.07528812
81Acute encephalopathy (HP:0006846)2.05421254
82Progressive macrocephaly (HP:0004481)2.05151007
83Mutism (HP:0002300)2.04513473
84Poor coordination (HP:0002370)2.04107225
85Nephroblastoma (Wilms tumor) (HP:0002667)2.03173668
86Insidious onset (HP:0003587)2.02029977
87Termporal pattern (HP:0011008)2.02029977
88Inappropriate behavior (HP:0000719)2.00315198
89Central scotoma (HP:0000603)2.00045718
90Specific learning disability (HP:0001328)1.99831240
91Hemiparesis (HP:0001269)1.99705736
92Embryonal renal neoplasm (HP:0011794)1.99581176
93Bradykinesia (HP:0002067)1.98990544
94Urinary bladder sphincter dysfunction (HP:0002839)1.98914336
95Atrophy/Degeneration involving motor neurons (HP:0007373)1.98406438
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.98113148
97Retinal dysplasia (HP:0007973)1.97721235
98Type II lissencephaly (HP:0007260)1.97002059
99Acute necrotizing encephalopathy (HP:0006965)1.96991803
100Unsteady gait (HP:0002317)1.96938470
101Meckel diverticulum (HP:0002245)1.96369739
102Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.95452508
103Myelodysplasia (HP:0002863)1.93976087
104Abnormal lung lobation (HP:0002101)1.92988815
105Poor suck (HP:0002033)1.91562372
106Abnormality of the duodenum (HP:0002246)1.90967975
107Abnormal spermatogenesis (HP:0008669)1.89931152
108Optic nerve hypoplasia (HP:0000609)1.89000375
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87937592
110Abnormality of alanine metabolism (HP:0010916)1.87937592
111Chromsome breakage (HP:0040012)1.87614073
112Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87377317
113Abnormal protein N-linked glycosylation (HP:0012347)1.87377317
114Abnormal protein glycosylation (HP:0012346)1.87377317
115Abnormal glycosylation (HP:0012345)1.87377317
116Supernumerary spleens (HP:0009799)1.86978828
117Hypoplasia of the brainstem (HP:0002365)1.86707004
118Aplasia/Hypoplasia of the brainstem (HP:0007362)1.86707004
119Rimmed vacuoles (HP:0003805)1.85891703
120Amyotrophic lateral sclerosis (HP:0007354)1.85560504
121Sloping forehead (HP:0000340)1.85347010
122Failure to thrive in infancy (HP:0001531)1.85023807
123Gait ataxia (HP:0002066)1.84787344
124Thyroid carcinoma (HP:0002890)1.84701050
125Dysmetria (HP:0001310)1.84314495
126Short tibia (HP:0005736)1.84186719
127Prolonged bleeding time (HP:0003010)1.81878779
128Increased CSF lactate (HP:0002490)1.81094329
129Abnormality of serum amino acid levels (HP:0003112)1.81067706
130Genetic anticipation (HP:0003743)1.79657511
131Hepatic necrosis (HP:0002605)1.79452013
132Ankle clonus (HP:0011448)1.78981910
133Biliary tract neoplasm (HP:0100574)1.77808137
134Mitochondrial inheritance (HP:0001427)1.76915584
135Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.76498607
136Degeneration of the lateral corticospinal tracts (HP:0002314)1.76498607
137Congenital stationary night blindness (HP:0007642)1.76249934
138Diplopia (HP:0000651)1.75714758
139Abnormality of binocular vision (HP:0011514)1.75714758
140Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75084185
141Decreased central vision (HP:0007663)1.74252251
142Genital tract atresia (HP:0001827)1.73103141
143Lissencephaly (HP:0001339)1.72472366
144Small hand (HP:0200055)1.72470152
145Azoospermia (HP:0000027)1.71750742
146Absent eyebrow (HP:0002223)1.71306095
147Gastrointestinal atresia (HP:0002589)1.71281851
148Abnormality of salivation (HP:0100755)1.70323087
149Volvulus (HP:0002580)1.70046839
150Supranuclear gaze palsy (HP:0000605)1.69533160
151Clubbing of toes (HP:0100760)1.68399695
152Vaginal atresia (HP:0000148)1.68163137
153Exotropia (HP:0000577)1.68038373
154Molar tooth sign on MRI (HP:0002419)1.68032402
155Abnormality of midbrain morphology (HP:0002418)1.68032402
156Abnormality of the fovea (HP:0000493)1.67850934
157Spastic gait (HP:0002064)1.67704099
158Abnormality of the corticospinal tract (HP:0002492)1.67400825
159Widely spaced teeth (HP:0000687)1.67070888
160Labial hypoplasia (HP:0000066)1.67004088
161Abnormality of the preputium (HP:0100587)1.66944942
162Male pseudohermaphroditism (HP:0000037)1.66603768
163Abnormality of glycine metabolism (HP:0010895)1.66422135
164Abnormality of serine family amino acid metabolism (HP:0010894)1.66422135
165Chromosomal breakage induced by crosslinking agents (HP:0003221)1.66275016
166Neoplasm of the colon (HP:0100273)1.66123259
167Anencephaly (HP:0002323)1.66031553
168Dyskinesia (HP:0100660)1.65906775
169Hyperthyroidism (HP:0000836)1.64279890
170Abnormal rod and cone electroretinograms (HP:0008323)1.63882279
171Impaired vibratory sensation (HP:0002495)1.63680365
172Delusions (HP:0000746)1.63424870
173Urinary urgency (HP:0000012)1.62754401
174Hyperalaninemia (HP:0003348)1.62682657

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.16078418
2CASK4.07072835
3FRK3.54162290
4EPHA43.23007451
5MAP3K123.14645528
6MAP3K43.13180340
7MARK13.01184719
8MAP2K72.90846301
9NUAK12.88618200
10MAP3K92.72691628
11MAP4K22.68942024
12RIPK42.57814351
13MINK12.49899186
14ACVR1B2.47884096
15TRIM282.45199336
16ZAK2.42751489
17MST42.41310085
18AKT32.32315475
19EIF2AK32.29986468
20PLK22.16025351
21MAP2K42.10130319
22PNCK1.96716460
23PLK41.92318354
24NTRK21.90053426
25CDK191.86578784
26TNIK1.85291578
27BMPR1B1.83658571
28DAPK21.78532841
29MAPK131.71624149
30SIK31.64195310
31DAPK11.60921339
32MKNK21.59864851
33KSR11.59747311
34CCNB11.59523875
35STK38L1.57709825
36BRSK21.51104512
37SGK21.48461159
38CAMKK21.47657131
39VRK11.38301932
40OBSCN1.35681152
41PRPF4B1.29428001
42MKNK11.29324726
43PAK61.28908702
44GRK51.27126882
45TAOK31.26564618
46WEE11.24320091
47CDK51.23250208
48PRKCG1.20298797
49KSR21.17008841
50TEC1.16593405
51ARAF1.15285576
52BRAF1.14167600
53TXK1.14071091
54TSSK61.13640908
55NME11.10671112
56SGK2231.08887933
57SGK4941.08887933
58BMPR21.05003316
59SIK21.04736589
60CAMK2A1.02851503
61DYRK1A1.01877338
62CSNK1G31.00634007
63CSNK1G11.00096753
64TTK0.97847003
65PLK10.95176632
66PDK20.93758493
67SGK30.92581103
68GRK10.92363398
69CAMK2B0.89209793
70EIF2AK10.89072675
71CSNK1A1L0.88436254
72NTRK10.87503431
73PBK0.86008591
74PTK2B0.84603181
75PHKG10.81632056
76PHKG20.81632056
77CAMKK10.81457888
78WNK30.79422059
79PIK3CG0.79139648
80BRD40.78929489
81EIF2AK20.78819987
82UHMK10.78264045
83GRK70.77601400
84YES10.75807522
85MAP3K130.73438942
86PDK30.72975510
87PDK40.72975510
88PLK30.72025959
89CDC70.70466137
90SGK10.69922235
91CDK180.68914462
92TYRO30.68634619
93ATR0.68055570
94STK30.64677116
95ADRBK10.63897145
96FES0.63387984
97CDK140.61780652
98NEK10.61330889
99PRKCE0.61260268
100ATM0.60842352
101CDK150.59684473
102CAMK10.59324253
103CDK11A0.59165301
104STK390.59061172
105ERBB30.58038098
106STK380.55985740
107NLK0.55025782
108OXSR10.52754899
109IRAK10.52145283
110BCR0.52136998
111STK160.51412744
112CDK30.51039009
113CAMK2D0.50784070
114LATS10.50412703
115DYRK20.49866134
116ADRBK20.49816779
117MAP3K20.47281225
118RAF10.46583347
119VRK20.46217209
120FER0.46008851
121RPS6KA40.43732213
122CSNK1G20.42863374
123TLK10.41631577
124FGFR20.41470595
125CAMK40.41015424
126TAOK20.40810377
127CDC42BPA0.39844357
128PINK10.39651979
129PRKG10.38751173
130GRK60.38334840
131PRKCQ0.38201105
132CSNK1D0.37247998
133RPS6KA30.36967796
134NEK60.36847524
135PAK30.36234258
136INSRR0.35510804
137CHEK20.35454076
138CSF1R0.35407172
139PRKCB0.35395115
140RET0.34761636
141CAMK2G0.34148437
142MUSK0.32902153
143MAPK100.32513455
144PIM10.31611168
145BUB10.31461629
146TAF10.30974350
147BCKDK0.30832608
148MAP3K50.30757251
149PRKACA0.30444744
150RPS6KA50.30078032
151TNK20.30055174
152ITK0.29988609
153SRPK10.29886338
154FGR0.29819156
155FLT30.29670346
156RPS6KB10.29419291
157MAPK80.28398174
158FYN0.28248888

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.26144586
2Non-homologous end-joining_Homo sapiens_hsa034503.65534509
3Synaptic vesicle cycle_Homo sapiens_hsa047213.37321358
4Proteasome_Homo sapiens_hsa030503.27023299
5Fanconi anemia pathway_Homo sapiens_hsa034602.94312838
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.93890686
7Homologous recombination_Homo sapiens_hsa034402.93180887
8Long-term potentiation_Homo sapiens_hsa047202.92433985
9Mismatch repair_Homo sapiens_hsa034302.77734332
10Propanoate metabolism_Homo sapiens_hsa006402.73257878
11Circadian entrainment_Homo sapiens_hsa047132.70303243
12Basal transcription factors_Homo sapiens_hsa030222.65884662
13GABAergic synapse_Homo sapiens_hsa047272.63113854
14Morphine addiction_Homo sapiens_hsa050322.57531119
15Olfactory transduction_Homo sapiens_hsa047402.55410253
16Glutamatergic synapse_Homo sapiens_hsa047242.47073173
17Amphetamine addiction_Homo sapiens_hsa050312.46387433
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.36925296
19Dopaminergic synapse_Homo sapiens_hsa047282.29319572
20Protein export_Homo sapiens_hsa030602.26283406
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.16194406
22Collecting duct acid secretion_Homo sapiens_hsa049662.16071310
23Taste transduction_Homo sapiens_hsa047422.13280124
24RNA polymerase_Homo sapiens_hsa030202.07074246
25RNA degradation_Homo sapiens_hsa030182.00198408
26Serotonergic synapse_Homo sapiens_hsa047261.94497314
27Insulin secretion_Homo sapiens_hsa049111.94335104
28Long-term depression_Homo sapiens_hsa047301.91156058
29Salivary secretion_Homo sapiens_hsa049701.85163922
30Phototransduction_Homo sapiens_hsa047441.82165634
31Cholinergic synapse_Homo sapiens_hsa047251.76670663
32Butanoate metabolism_Homo sapiens_hsa006501.73045273
33Nucleotide excision repair_Homo sapiens_hsa034201.72883371
34Renin secretion_Homo sapiens_hsa049241.72226778
35RNA transport_Homo sapiens_hsa030131.69405735
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.68193724
37Cocaine addiction_Homo sapiens_hsa050301.67209718
38Calcium signaling pathway_Homo sapiens_hsa040201.63673053
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59339907
40Fatty acid elongation_Homo sapiens_hsa000621.57881632
41Nitrogen metabolism_Homo sapiens_hsa009101.56532368
42Base excision repair_Homo sapiens_hsa034101.56376687
43Selenocompound metabolism_Homo sapiens_hsa004501.56365286
44Vibrio cholerae infection_Homo sapiens_hsa051101.54857275
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54818819
46Oxytocin signaling pathway_Homo sapiens_hsa049211.53934648
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53198372
48Cell cycle_Homo sapiens_hsa041101.52721069
49Gastric acid secretion_Homo sapiens_hsa049711.48516785
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46311803
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40968992
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38639958
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.35365887
54DNA replication_Homo sapiens_hsa030301.35161231
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31683474
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.24536767
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21827784
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20826365
59Oocyte meiosis_Homo sapiens_hsa041141.19533491
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18934879
61Gap junction_Homo sapiens_hsa045401.16524700
62GnRH signaling pathway_Homo sapiens_hsa049121.14170702
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11638258
64Spliceosome_Homo sapiens_hsa030401.06804447
65Type II diabetes mellitus_Homo sapiens_hsa049301.06179924
66cAMP signaling pathway_Homo sapiens_hsa040241.06157344
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04955217
68Peroxisome_Homo sapiens_hsa041461.03429665
69Type I diabetes mellitus_Homo sapiens_hsa049401.02194258
70Estrogen signaling pathway_Homo sapiens_hsa049150.98880369
71Purine metabolism_Homo sapiens_hsa002300.96852379
72ErbB signaling pathway_Homo sapiens_hsa040120.96378066
73Cardiac muscle contraction_Homo sapiens_hsa042600.95810113
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95454161
75Circadian rhythm_Homo sapiens_hsa047100.95215717
76Oxidative phosphorylation_Homo sapiens_hsa001900.92809606
77One carbon pool by folate_Homo sapiens_hsa006700.92620981
78Axon guidance_Homo sapiens_hsa043600.91291121
79p53 signaling pathway_Homo sapiens_hsa041150.90765480
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90565552
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89107349
82Pyrimidine metabolism_Homo sapiens_hsa002400.87836131
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86180668
84Alzheimers disease_Homo sapiens_hsa050100.83517739
85Alcoholism_Homo sapiens_hsa050340.83335216
86Glioma_Homo sapiens_hsa052140.82285665
87Inositol phosphate metabolism_Homo sapiens_hsa005620.81392333
88Melanogenesis_Homo sapiens_hsa049160.81159232
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79920125
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79657153
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79516503
92Parkinsons disease_Homo sapiens_hsa050120.77855062
93Linoleic acid metabolism_Homo sapiens_hsa005910.77634495
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.77112105
95Ether lipid metabolism_Homo sapiens_hsa005650.75623715
96Tryptophan metabolism_Homo sapiens_hsa003800.75213329
97beta-Alanine metabolism_Homo sapiens_hsa004100.74457570
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74238608
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.74165483
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72275944
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70465803
102MAPK signaling pathway_Homo sapiens_hsa040100.66584720
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66506665
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.65900882
105Fatty acid metabolism_Homo sapiens_hsa012120.65524771
106Pancreatic secretion_Homo sapiens_hsa049720.65238936
107Platelet activation_Homo sapiens_hsa046110.65119762
108Primary immunodeficiency_Homo sapiens_hsa053400.63361634
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62585814
110Asthma_Homo sapiens_hsa053100.61437071
111Steroid biosynthesis_Homo sapiens_hsa001000.58925497
112Glucagon signaling pathway_Homo sapiens_hsa049220.58591490
113Huntingtons disease_Homo sapiens_hsa050160.58469881
114Glycerolipid metabolism_Homo sapiens_hsa005610.58218026
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56939684
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56257843
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53955860
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53074472
119African trypanosomiasis_Homo sapiens_hsa051430.51484454
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.51229337
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49904575
122Sulfur metabolism_Homo sapiens_hsa009200.49039692
123Thyroid hormone synthesis_Homo sapiens_hsa049180.48532392
124Metabolic pathways_Homo sapiens_hsa011000.46512643
125Ras signaling pathway_Homo sapiens_hsa040140.45747535
126Rheumatoid arthritis_Homo sapiens_hsa053230.45569266
127Choline metabolism in cancer_Homo sapiens_hsa052310.45566698
128Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45551924
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44548877
130Hematopoietic cell lineage_Homo sapiens_hsa046400.44492349
131Phagosome_Homo sapiens_hsa041450.43751647
132Dilated cardiomyopathy_Homo sapiens_hsa054140.42865793
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41856645
134VEGF signaling pathway_Homo sapiens_hsa043700.41810234
135Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41101038
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.40228084
137Regulation of autophagy_Homo sapiens_hsa041400.39601911
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.38983436
139mTOR signaling pathway_Homo sapiens_hsa041500.38958642
140TGF-beta signaling pathway_Homo sapiens_hsa043500.37310008
141Pyruvate metabolism_Homo sapiens_hsa006200.36829485
142Insulin signaling pathway_Homo sapiens_hsa049100.36394027
143Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36040051
144Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35985096
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34811343
146Dorso-ventral axis formation_Homo sapiens_hsa043200.34712843
147Arachidonic acid metabolism_Homo sapiens_hsa005900.34451901
148Wnt signaling pathway_Homo sapiens_hsa043100.33996723
149Rap1 signaling pathway_Homo sapiens_hsa040150.33970778
150Jak-STAT signaling pathway_Homo sapiens_hsa046300.33581533
151Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31901772
152Colorectal cancer_Homo sapiens_hsa052100.31183310
153Fatty acid degradation_Homo sapiens_hsa000710.31007808
154Glutathione metabolism_Homo sapiens_hsa004800.30795300
155Caffeine metabolism_Homo sapiens_hsa002320.27826103
156Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25325978
157Chemokine signaling pathway_Homo sapiens_hsa040620.25186158
158Endometrial cancer_Homo sapiens_hsa052130.24661723
159Maturity onset diabetes of the young_Homo sapiens_hsa049500.23631969
160Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.22598782
161Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22462109
162Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.22095233
163mRNA surveillance pathway_Homo sapiens_hsa030150.20528930
164Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.19733465
165Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18503022
166Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18461221
167Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18192299

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