ARMCX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ALEX family of proteins and may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and two Armadillo (arm) repeats. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members, including ALEX2 and ALEX3, on the X chromosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.22298414
2pyrimidine nucleobase catabolic process (GO:0006208)5.02856200
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.91486745
4neuron cell-cell adhesion (GO:0007158)4.73578368
5regulation of synaptic vesicle exocytosis (GO:2000300)4.69451680
6neuronal action potential propagation (GO:0019227)4.67383263
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.60042964
8vocalization behavior (GO:0071625)4.58964272
9glutamate secretion (GO:0014047)4.57638872
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.29247862
11protein localization to synapse (GO:0035418)4.24180727
12synaptic vesicle maturation (GO:0016188)4.17574211
13neurotransmitter secretion (GO:0007269)4.09299160
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.08028441
15regulation of synaptic vesicle transport (GO:1902803)4.03882555
16nucleobase catabolic process (GO:0046113)4.00656051
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.00131404
18regulation of glutamate receptor signaling pathway (GO:1900449)3.87295425
19negative regulation of synaptic transmission, GABAergic (GO:0032229)3.82369988
20neuron-neuron synaptic transmission (GO:0007270)3.81247718
21negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.81211565
22proline transport (GO:0015824)3.80371548
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.68859141
24synaptic transmission, glutamatergic (GO:0035249)3.62350791
25synaptic vesicle endocytosis (GO:0048488)3.60793898
26ionotropic glutamate receptor signaling pathway (GO:0035235)3.58040472
27gamma-aminobutyric acid signaling pathway (GO:0007214)3.57680573
28cell migration in hindbrain (GO:0021535)3.57513846
29locomotory exploration behavior (GO:0035641)3.56742733
30neuron recognition (GO:0008038)3.53488395
31presynaptic membrane assembly (GO:0097105)3.52652217
32neurotransmitter transport (GO:0006836)3.51109995
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.50224380
34glutamate receptor signaling pathway (GO:0007215)3.37254148
35exploration behavior (GO:0035640)3.34457674
36postsynaptic membrane organization (GO:0001941)3.31984816
37presynaptic membrane organization (GO:0097090)3.31470658
38regulation of neuronal synaptic plasticity (GO:0048168)3.30367041
39regulation of synapse structural plasticity (GO:0051823)3.28237954
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.27971950
41innervation (GO:0060384)3.27897989
42positive regulation of synaptic transmission, GABAergic (GO:0032230)3.27542700
43regulation of long-term neuronal synaptic plasticity (GO:0048169)3.27491171
44negative regulation of microtubule polymerization (GO:0031115)3.27284233
45regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.26246599
46axon extension involved in axon guidance (GO:0048846)3.23478915
47neuron projection extension involved in neuron projection guidance (GO:1902284)3.23478915
48regulation of neurotransmitter secretion (GO:0046928)3.22939913
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.22146371
50negative regulation of dendrite morphogenesis (GO:0050774)3.18278624
51cerebellar Purkinje cell differentiation (GO:0021702)3.17424736
52calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.17107090
53positive regulation of mitochondrial fission (GO:0090141)3.15914460
54gamma-aminobutyric acid transport (GO:0015812)3.15832033
55regulation of synaptic transmission, glutamatergic (GO:0051966)3.13741429
56epithelial cell differentiation involved in kidney development (GO:0035850)3.13740126
57regulation of neurotransmitter levels (GO:0001505)3.13449670
58membrane depolarization during action potential (GO:0086010)3.12977417
59transmission of nerve impulse (GO:0019226)3.12876271
60axonal fasciculation (GO:0007413)3.09260821
61regulation of excitatory postsynaptic membrane potential (GO:0060079)3.09045409
62layer formation in cerebral cortex (GO:0021819)3.08138311
63behavioral response to ethanol (GO:0048149)3.08002436
64positive regulation of synapse assembly (GO:0051965)3.07983995
65neurotransmitter-gated ion channel clustering (GO:0072578)3.07037621
66synaptic vesicle transport (GO:0048489)3.06333190
67establishment of synaptic vesicle localization (GO:0097480)3.06333190
68response to histamine (GO:0034776)3.02831815
69regulation of neurotransmitter transport (GO:0051588)3.02464514
70regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.02304619
71ATP hydrolysis coupled proton transport (GO:0015991)3.01950717
72energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.01950717
73regulation of synaptic transmission, GABAergic (GO:0032228)3.00705632
74axon extension (GO:0048675)3.00563579
75retinal ganglion cell axon guidance (GO:0031290)3.00041369
76regulation of postsynaptic membrane potential (GO:0060078)2.99780925
77positive regulation of synapse maturation (GO:0090129)2.96201992
78neuromuscular process controlling posture (GO:0050884)2.95633584
79long-term synaptic potentiation (GO:0060291)2.94969491
80neuromuscular synaptic transmission (GO:0007274)2.94394542
81synapse assembly (GO:0007416)2.91420859
82activation of protein kinase A activity (GO:0034199)2.90007468
83positive regulation of membrane potential (GO:0045838)2.89658975
84synaptic transmission (GO:0007268)2.89520842
85regulation of vesicle fusion (GO:0031338)2.89328929
86neuronal action potential (GO:0019228)2.88468732
87negative regulation of axon guidance (GO:1902668)2.87603884
88negative regulation of dendrite development (GO:2000171)2.87185955
89dendritic spine morphogenesis (GO:0060997)2.86270709
90behavioral response to nicotine (GO:0035095)2.86168057
91auditory behavior (GO:0031223)2.85922966
92membrane depolarization (GO:0051899)2.85717581
93dendrite development (GO:0016358)2.85300229
94mating behavior (GO:0007617)2.85224728
95mechanosensory behavior (GO:0007638)2.85133843
96startle response (GO:0001964)2.84765548
97establishment of vesicle localization (GO:0051650)2.83159843
98growth hormone secretion (GO:0030252)2.82971010
99central nervous system projection neuron axonogenesis (GO:0021952)2.82549069
100membrane hyperpolarization (GO:0060081)2.82278030
101detection of calcium ion (GO:0005513)2.81851866
102behavioral response to cocaine (GO:0048148)2.81828059
103G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.79536169
104calcium-mediated signaling using intracellular calcium source (GO:0035584)2.79464232
105transferrin transport (GO:0033572)2.79299274
106neurotransmitter uptake (GO:0001504)2.79265107
107striatum development (GO:0021756)2.78148092
108short-term memory (GO:0007614)2.76338016
109regulation of synaptic plasticity (GO:0048167)2.75489661
110regulation of feeding behavior (GO:0060259)2.74767960
111calcium ion-dependent exocytosis (GO:0017156)2.74206425
112regulation of respiratory system process (GO:0044065)2.73635058
113negative regulation of neurotransmitter transport (GO:0051589)2.72878569
114regulation of cAMP-dependent protein kinase activity (GO:2000479)2.72750525
115regulation of protein kinase A signaling (GO:0010738)2.71869016
116negative regulation of cytosolic calcium ion concentration (GO:0051481)2.71253813
117somite development (GO:0061053)2.70776453
118adult walking behavior (GO:0007628)2.68298303
119protein localization to cilium (GO:0061512)2.68035189
120sequestering of actin monomers (GO:0042989)2.67571235
121synaptic transmission, cholinergic (GO:0007271)2.60801262
122nonmotile primary cilium assembly (GO:0035058)2.59600682
123muscle filament sliding (GO:0030049)2.56347119
124actin-myosin filament sliding (GO:0033275)2.56347119
125adult feeding behavior (GO:0008343)2.55790545
126ganglion development (GO:0061548)2.55181455
127regulation of axon guidance (GO:1902667)2.55154009
128positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.54405898
129dendrite morphogenesis (GO:0048813)2.54052473
130establishment of mitochondrion localization (GO:0051654)2.53557720
131lens morphogenesis in camera-type eye (GO:0002089)2.52788824
132protein polyglutamylation (GO:0018095)2.48675649
133regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.42632450
134limb bud formation (GO:0060174)2.39200932
135neuron projection extension (GO:1990138)2.37823279
136spinal cord development (GO:0021510)2.37784652
137regulation of cell communication by electrical coupling (GO:0010649)2.36684662
138response to auditory stimulus (GO:0010996)2.36054762
139regulation of synapse assembly (GO:0051963)2.35784102
140central nervous system neuron axonogenesis (GO:0021955)2.35156575
141neurofilament cytoskeleton organization (GO:0060052)2.33585070
142righting reflex (GO:0060013)2.30894064
143synapse organization (GO:0050808)2.29792816
144membrane assembly (GO:0071709)2.28424788
145homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.27911999
146neuronal ion channel clustering (GO:0045161)2.27346780
147substrate-independent telencephalic tangential migration (GO:0021826)2.27027588
148substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.27027588
149actin-mediated cell contraction (GO:0070252)2.26911776
150heart contraction (GO:0060047)2.26892333
151heart process (GO:0003015)2.26892333
152metanephric mesenchyme development (GO:0072075)2.26297808
153cardiac ventricle formation (GO:0003211)2.25930074
154negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.25746501
155regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.24748442
156behavioral fear response (GO:0001662)2.24347587
157behavioral defense response (GO:0002209)2.24347587
158cerebral cortex radially oriented cell migration (GO:0021799)2.21811931

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.62048373
2GBX2_23144817_ChIP-Seq_PC3_Human4.21373027
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13446100
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98979029
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97886250
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.69818998
7TAF15_26573619_Chip-Seq_HEK293_Human2.67429225
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65507017
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59158188
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59158188
11REST_21632747_ChIP-Seq_MESCs_Mouse2.56514915
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54558353
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54116726
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.51315289
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.50559993
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49325549
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.41359427
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30413674
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26545139
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.24808651
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.23707178
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.15665276
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.12114930
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.06850746
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05873293
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.02196292
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99711886
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97192793
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91928998
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.86866061
31P300_19829295_ChIP-Seq_ESCs_Human1.79544970
32IGF1R_20145208_ChIP-Seq_DFB_Human1.74797844
33DROSHA_22980978_ChIP-Seq_HELA_Human1.70515523
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.70196104
35SMAD4_21799915_ChIP-Seq_A2780_Human1.70072382
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68891099
37RNF2_27304074_Chip-Seq_NSC_Mouse1.66768001
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66171810
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64443243
40FUS_26573619_Chip-Seq_HEK293_Human1.61814044
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59710728
42ZNF274_21170338_ChIP-Seq_K562_Hela1.59533774
43VDR_22108803_ChIP-Seq_LS180_Human1.56674928
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.54667521
45AR_21572438_ChIP-Seq_LNCaP_Human1.53697277
46* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53469340
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49504685
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49461036
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48813410
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.42425509
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.37944815
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37766825
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.36780078
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36379150
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35878561
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34811134
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34393438
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.31561719
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.28911035
60AR_25329375_ChIP-Seq_VCAP_Human1.28525901
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28298966
62KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.26138809
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24345732
64EP300_21415370_ChIP-Seq_HL-1_Mouse1.23908073
65STAT3_23295773_ChIP-Seq_U87_Human1.22788883
66WT1_19549856_ChIP-ChIP_CCG9911_Human1.20730878
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.19046675
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.16578482
69ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16386644
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15001864
71CBP_20019798_ChIP-Seq_JUKART_Human1.15001864
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14570201
73NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14570201
74JUN_21703547_ChIP-Seq_K562_Human1.11775559
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11515156
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10898724
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10258484
78RUNX2_22187159_ChIP-Seq_PCA_Human1.09140021
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08890702
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08589219
81RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08274706
82ER_23166858_ChIP-Seq_MCF-7_Human1.06815752
83CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.05983431
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05785318
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05438814
86HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05259855
87TP53_18474530_ChIP-ChIP_U2OS_Human1.05006234
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04989469
89AR_19668381_ChIP-Seq_PC3_Human1.03738717
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03083793
91TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02996849
92PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02850061
93YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02707460
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.02658001
95TCF4_23295773_ChIP-Seq_U87_Human1.01410940
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01399740
97RING1B_27294783_Chip-Seq_NPCs_Mouse1.00968078
98LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00882766
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00281546
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00061815
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99511134
102EWS_26573619_Chip-Seq_HEK293_Human0.98672230
103RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98515744
104P53_22387025_ChIP-Seq_ESCs_Mouse0.98230728
105AHR_22903824_ChIP-Seq_MCF-7_Human0.97564565
106SOX2_16153702_ChIP-ChIP_HESCs_Human0.97440911
107FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97144570
108SMAD3_21741376_ChIP-Seq_ESCs_Human0.96583162
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96004979
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94445315
111PRDM14_20953172_ChIP-Seq_ESCs_Human0.94118834
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92688496
113SOX9_26525672_Chip-Seq_HEART_Mouse0.92019310
114CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90427903
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89998113
116STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89594924
117NANOG_18555785_Chip-Seq_ESCs_Mouse0.89519191
118CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87594109
119TP53_20018659_ChIP-ChIP_R1E_Mouse0.86791108
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85866191
121SMAD_19615063_ChIP-ChIP_OVARY_Human0.85598399
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85367054
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85367054
124* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84458656

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.38443441
2MP0003880_abnormal_central_pattern4.30462985
3MP0004270_analgesia3.46571416
4MP0003635_abnormal_synaptic_transmissio3.40725899
5MP0001968_abnormal_touch/_nociception3.25450305
6MP0009046_muscle_twitch2.96170056
7MP0002735_abnormal_chemical_nociception2.87580440
8MP0009745_abnormal_behavioral_response2.87524228
9MP0002734_abnormal_mechanical_nocicepti2.79627335
10MP0002064_seizures2.76152325
11MP0002736_abnormal_nociception_after2.74593454
12MP0002063_abnormal_learning/memory/cond2.70941235
13MP0003122_maternal_imprinting2.63350301
14MP0006276_abnormal_autonomic_nervous2.58326838
15MP0002272_abnormal_nervous_system2.55302075
16MP0002572_abnormal_emotion/affect_behav2.52410448
17MP0002733_abnormal_thermal_nociception2.32936346
18MP0005423_abnormal_somatic_nervous2.30653836
19MP0001486_abnormal_startle_reflex2.10736791
20MP0001970_abnormal_pain_threshold2.10227605
21MP0002184_abnormal_innervation2.05407497
22MP0002067_abnormal_sensory_capabilities1.99540259
23MP0001440_abnormal_grooming_behavior1.93869224
24MP0001501_abnormal_sleep_pattern1.92096366
25MP0003787_abnormal_imprinting1.84683972
26MP0000778_abnormal_nervous_system1.77715841
27MP0001986_abnormal_taste_sensitivity1.76879119
28MP0002557_abnormal_social/conspecific_i1.66961123
29MP0001529_abnormal_vocalization1.66747659
30MP0002102_abnormal_ear_morphology1.66584449
31MP0002822_catalepsy1.65355382
32MP0004858_abnormal_nervous_system1.63898310
33MP0009780_abnormal_chondrocyte_physiolo1.63877922
34MP0001188_hyperpigmentation1.63123587
35MP0005646_abnormal_pituitary_gland1.63113730
36MP0004924_abnormal_behavior1.61923899
37MP0005386_behavior/neurological_phenoty1.61923899
38MP0001905_abnormal_dopamine_level1.57879192
39MP0000955_abnormal_spinal_cord1.56399789
40MP0004811_abnormal_neuron_physiology1.54542745
41MP0010030_abnormal_orbit_morphology1.54192680
42MP0004142_abnormal_muscle_tone1.52919727
43MP0001984_abnormal_olfaction1.50023933
44MP0000749_muscle_degeneration1.49218680
45MP0008438_abnormal_cutaneous_collagen1.46375809
46MP0008569_lethality_at_weaning1.45352006
47MP0010386_abnormal_urinary_bladder1.44600285
48MP0005645_abnormal_hypothalamus_physiol1.43695853
49MP0002882_abnormal_neuron_morphology1.41828248
50MP0002909_abnormal_adrenal_gland1.32968617
51MP0002066_abnormal_motor_capabilities/c1.30072966
52MP0001542_abnormal_bone_strength1.29669645
53MP0002837_dystrophic_cardiac_calcinosis1.28300936
54MP0003121_genomic_imprinting1.25793842
55MP0003283_abnormal_digestive_organ1.23265368
56MP0000013_abnormal_adipose_tissue1.23167436
57MP0000049_abnormal_middle_ear1.21414038
58MP0003879_abnormal_hair_cell1.18199613
59MP0005620_abnormal_muscle_contractility1.16000977
60MP0004272_abnormal_basement_membrane1.14801088
61MP0000750_abnormal_muscle_regeneration1.12637228
62MP0005499_abnormal_olfactory_system1.12157166
63MP0005394_taste/olfaction_phenotype1.12157166
64MP0006072_abnormal_retinal_apoptosis1.10855388
65MP0005257_abnormal_intraocular_pressure1.10808595
66MP0003385_abnormal_body_wall1.10705260
67MP0002751_abnormal_autonomic_nervous1.08780920
68MP0000751_myopathy1.07508373
69MP0003329_amyloid_beta_deposits1.07280102
70MP0002152_abnormal_brain_morphology1.04068687
71MP0008877_abnormal_DNA_methylation1.03690743
72MP0004084_abnormal_cardiac_muscle1.03536255
73MP0001502_abnormal_circadian_rhythm1.03086756
74MP0002332_abnormal_exercise_endurance1.02179181
75MP0010368_abnormal_lymphatic_system1.01935245
76MP0000631_abnormal_neuroendocrine_gland1.01824447
77MP0005551_abnormal_eye_electrophysiolog1.01639742
78MP0000516_abnormal_urinary_system0.99518235
79MP0005367_renal/urinary_system_phenotyp0.99518235
80MP0005275_abnormal_skin_tensile0.99504505
81MP0002752_abnormal_somatic_nervous0.99318045
82MP0002638_abnormal_pupillary_reflex0.98571240
83MP0004885_abnormal_endolymph0.97960184
84MP0003011_delayed_dark_adaptation0.97776077
85MP0004145_abnormal_muscle_electrophysio0.96843572
86MP0003633_abnormal_nervous_system0.96686152
87MP0003123_paternal_imprinting0.96173148
88MP0002938_white_spotting0.96075092
89MP0002229_neurodegeneration0.95772772
90MP0009384_cardiac_valve_regurgitation0.94053596
91MP0002234_abnormal_pharynx_morphology0.92774380
92MP0002106_abnormal_muscle_physiology0.92693111
93MP0003942_abnormal_urinary_system0.92104149
94MP0005503_abnormal_tendon_morphology0.91142505
95MP0001963_abnormal_hearing_physiology0.89532137
96MP0002295_abnormal_pulmonary_circulatio0.89289011
97MP0000569_abnormal_digit_pigmentation0.88817220
98MP0005248_abnormal_Harderian_gland0.87836354
99MP0002972_abnormal_cardiac_muscle0.87157575
100MP0006054_spinal_hemorrhage0.86920126
101MP0003631_nervous_system_phenotype0.86609288
102MP0003279_aneurysm0.86067011
103MP0005623_abnormal_meninges_morphology0.85915804
104MP0003567_abnormal_fetal_cardiomyocyte0.84886290
105MP0004233_abnormal_muscle_weight0.83586295
106MP0002233_abnormal_nose_morphology0.83155780
107MP0001879_abnormal_lymphatic_vessel0.82385405
108MP0003634_abnormal_glial_cell0.81341254
109MP0004085_abnormal_heartbeat0.80971749
110MP0004742_abnormal_vestibular_system0.80481554
111MP0008789_abnormal_olfactory_epithelium0.80066305
112MP0005171_absent_coat_pigmentation0.79334967
113MP0003183_abnormal_peptide_metabolism0.78007165
114MP0001664_abnormal_digestion0.77542451
115MP0002069_abnormal_eating/drinking_beha0.77341652
116MP0004215_abnormal_myocardial_fiber0.75780070
117MP0006292_abnormal_olfactory_placode0.75024403
118MP0001485_abnormal_pinna_reflex0.73260065
119MP0002653_abnormal_ependyma_morphology0.73208417
120MP0004043_abnormal_pH_regulation0.70033497
121MP0000026_abnormal_inner_ear0.69160067
122MP0002876_abnormal_thyroid_physiology0.68852173
123MP0008872_abnormal_physiological_respon0.68705519
124MP0003861_abnormal_nervous_system0.67229233
125MP0005379_endocrine/exocrine_gland_phen0.66648598
126MP0001943_abnormal_respiration0.66586540
127MP0003632_abnormal_nervous_system0.64894031
128MP0005253_abnormal_eye_physiology0.63762924
129MP0005409_darkened_coat_color0.60404518
130MP0001299_abnormal_eye_distance/0.58496208
131MP0000534_abnormal_ureter_morphology0.58334947
132MP0004133_heterotaxia0.58118208
133MP0005535_abnormal_body_temperature0.57571877
134MP0003137_abnormal_impulse_conducting0.56164317

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.41216987
2Atonic seizures (HP:0010819)5.13818364
3Myokymia (HP:0002411)5.10243776
4Focal seizures (HP:0007359)4.76990655
5Visual hallucinations (HP:0002367)4.72112341
6Febrile seizures (HP:0002373)4.44729155
7Epileptic encephalopathy (HP:0200134)4.30839659
8Absence seizures (HP:0002121)3.87549171
9Pheochromocytoma (HP:0002666)3.79439976
10Dialeptic seizures (HP:0011146)3.66349562
11Progressive cerebellar ataxia (HP:0002073)3.61158064
12Neuroendocrine neoplasm (HP:0100634)3.49899273
13Limb dystonia (HP:0002451)3.36405147
14Generalized tonic-clonic seizures (HP:0002069)3.22607302
15Exercise-induced muscle cramps (HP:0003710)3.13589971
16Hypothermia (HP:0002045)2.89822449
17Hyperventilation (HP:0002883)2.88401052
18Action tremor (HP:0002345)2.87557478
19Amblyopia (HP:0000646)2.77867308
20Gait imbalance (HP:0002141)2.76705534
21Abnormality of the hip-girdle musculature (HP:0001445)2.74551514
22Abnormality of the musculature of the pelvis (HP:0001469)2.74551514
23Broad-based gait (HP:0002136)2.72326433
24Shoulder girdle muscle weakness (HP:0003547)2.71294903
25Rimmed vacuoles (HP:0003805)2.68719497
26Delayed gross motor development (HP:0002194)2.65580661
27Failure to thrive in infancy (HP:0001531)2.62674162
28Abnormal hair whorl (HP:0010721)2.60634496
29Supranuclear gaze palsy (HP:0000605)2.58396686
30Termporal pattern (HP:0011008)2.56941350
31Insidious onset (HP:0003587)2.56941350
32Ankle clonus (HP:0011448)2.53020968
33Truncal ataxia (HP:0002078)2.52280944
34Type 1 muscle fiber predominance (HP:0003803)2.48684857
35Decreased muscle mass (HP:0003199)2.45124513
36Congenital primary aphakia (HP:0007707)2.45036468
37Abnormality of the calf musculature (HP:0001430)2.42800718
38Gaze-evoked nystagmus (HP:0000640)2.42499532
39Poor suck (HP:0002033)2.41777526
40Medial flaring of the eyebrow (HP:0010747)2.41761107
41Hemiparesis (HP:0001269)2.40577896
42Acute necrotizing encephalopathy (HP:0006965)2.39575824
43Abnormality of the lower motor neuron (HP:0002366)2.38960199
44Anxiety (HP:0000739)2.38769437
45Epileptiform EEG discharges (HP:0011182)2.32393739
46Progressive inability to walk (HP:0002505)2.32036547
47Genital tract atresia (HP:0001827)2.31863477
48Impaired vibration sensation in the lower limbs (HP:0002166)2.31831955
49Distal arthrogryposis (HP:0005684)2.30934885
50Vaginal atresia (HP:0000148)2.29378321
51Depression (HP:0000716)2.28890789
52Abnormal eating behavior (HP:0100738)2.28216856
53Limb-girdle muscle weakness (HP:0003325)2.26160667
54Abnormal mitochondria in muscle tissue (HP:0008316)2.24595852
55Nephrogenic diabetes insipidus (HP:0009806)2.24171681
56Limb-girdle muscle atrophy (HP:0003797)2.24162266
57Specific learning disability (HP:0001328)2.24038289
58EEG with generalized epileptiform discharges (HP:0011198)2.23834354
59Dysdiadochokinesis (HP:0002075)2.22893502
60Neoplasm of the peripheral nervous system (HP:0100007)2.21112169
61Cortical dysplasia (HP:0002539)2.21093218
62Hypoventilation (HP:0002791)2.19077434
63Retinal dysplasia (HP:0007973)2.17673501
64Polyphagia (HP:0002591)2.17092750
65Myotonia (HP:0002486)2.17007679
66Poor eye contact (HP:0000817)2.14595847
67Progressive macrocephaly (HP:0004481)2.14568505
68Broad foot (HP:0001769)2.14528033
69Scanning speech (HP:0002168)2.12614044
70Impaired pain sensation (HP:0007328)2.11130906
71Abnormality of pain sensation (HP:0010832)2.11130906
72Abnormality of the corticospinal tract (HP:0002492)2.10216373
73Hypoplasia of the brainstem (HP:0002365)2.09830563
74Aplasia/Hypoplasia of the brainstem (HP:0007362)2.09830563
75Impaired smooth pursuit (HP:0007772)2.09677571
76Spastic gait (HP:0002064)2.09628680
77Agitation (HP:0000713)2.09384815
78Nephronophthisis (HP:0000090)2.09370245
79Hypsarrhythmia (HP:0002521)2.08388833
80Menstrual irregularities (HP:0000858)2.08086749
81Sleep apnea (HP:0010535)2.07611619
82Calf muscle hypertrophy (HP:0008981)2.07412148
83Left ventricular hypertrophy (HP:0001712)2.07061766
84Prominent supraorbital ridges (HP:0000336)2.04679719
85Diplopia (HP:0000651)2.04141175
86Abnormality of binocular vision (HP:0011514)2.04141175
87Dysmetria (HP:0001310)2.03856563
88Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.03515536
89Narrow nasal bridge (HP:0000446)2.03362860
90True hermaphroditism (HP:0010459)2.02125546
91Nemaline bodies (HP:0003798)2.02036885
92Muscle fiber inclusion bodies (HP:0100299)2.01549408
93Excessive salivation (HP:0003781)2.01256606
94Drooling (HP:0002307)2.01256606
95Protruding tongue (HP:0010808)1.99383151
96Atrophy/Degeneration involving motor neurons (HP:0007373)1.98138190
97Impaired social interactions (HP:0000735)1.97734749
98Abnormal social behavior (HP:0012433)1.97734749
99Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.94694348
100Pancreatic fibrosis (HP:0100732)1.94671512
101Molar tooth sign on MRI (HP:0002419)1.93779671
102Abnormality of midbrain morphology (HP:0002418)1.93779671
103Pelvic girdle muscle weakness (HP:0003749)1.93618507
104Urinary urgency (HP:0000012)1.92327985
105Pachygyria (HP:0001302)1.91529774
106Mitochondrial inheritance (HP:0001427)1.88667873
107Methylmalonic acidemia (HP:0002912)1.87794618
108Urinary bladder sphincter dysfunction (HP:0002839)1.87337854
109Muscle hypertrophy of the lower extremities (HP:0008968)1.87184128
110Aplasia/Hypoplasia of the lens (HP:0008063)1.86430396
111Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86353070
112Postural tremor (HP:0002174)1.85596281
113Decreased testicular size (HP:0008734)1.85056083
114Ulnar claw (HP:0001178)1.84987777
115Generalized hypotonia (HP:0001290)1.84375344
116Bradykinesia (HP:0002067)1.83465777
117Bifid tongue (HP:0010297)1.82849582
118Dysautonomia (HP:0002459)1.81526412
119Sudden death (HP:0001699)1.80209160
120Fetal akinesia sequence (HP:0001989)1.80068620
121Inability to walk (HP:0002540)1.79401107
122Spastic tetraplegia (HP:0002510)1.79233514
123Round ear (HP:0100830)1.79079217
124Esotropia (HP:0000565)1.78409476
125Delusions (HP:0000746)1.78180343
126Oligomenorrhea (HP:0000876)1.78030758
127Amyotrophic lateral sclerosis (HP:0007354)1.77728261
128Hyperthyroidism (HP:0000836)1.76588118
129Abnormality of the labia minora (HP:0012880)1.75638981
130Abnormality of ocular smooth pursuit (HP:0000617)1.75459711
131Degeneration of the lateral corticospinal tracts (HP:0002314)1.75353953
132Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.75353953
133Postural instability (HP:0002172)1.74793220
134Hepatoblastoma (HP:0002884)1.74126402
135Lissencephaly (HP:0001339)1.73221865
136Peripheral hypomyelination (HP:0007182)1.72756959
137Cerebral inclusion bodies (HP:0100314)1.69168473
138Aplasia/Hypoplasia of the tongue (HP:0010295)1.69074430
139Respiratory insufficiency due to muscle weakness (HP:0002747)1.68899230
140Mutism (HP:0002300)1.68442724
141Muscle fiber splitting (HP:0003555)1.67895637
142Lower limb muscle weakness (HP:0007340)1.67775486
143Slender build (HP:0001533)1.67642736
144Psychosis (HP:0000709)1.67053155
145Focal dystonia (HP:0004373)1.65677745
146Poor coordination (HP:0002370)1.64986668
147Abnormality of the shoulder girdle musculature (HP:0001435)1.63941888
148Short tibia (HP:0005736)1.63023602
149Upper limb muscle weakness (HP:0003484)1.60732573
150Muscular hypotonia of the trunk (HP:0008936)1.60250890
151Postaxial hand polydactyly (HP:0001162)1.60024137
152Optic nerve hypoplasia (HP:0000609)1.59917308
153Wrist flexion contracture (HP:0001239)1.59836978
154Gowers sign (HP:0003391)1.58522027
155Septo-optic dysplasia (HP:0100842)1.57936243
156Anterior segment dysgenesis (HP:0007700)1.57762575
157Abnormality of the renal medulla (HP:0100957)1.57062142

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.16279603
2CASK3.74190682
3MAP3K43.47037354
4MAP2K73.15059728
5MAP3K122.93632540
6MAP3K92.89449991
7MARK12.84286090
8TRIM282.82930738
9MINK12.58753261
10EPHA42.39422795
11TIE12.39409059
12MAP4K22.28339375
13GRK52.09441782
14MAP2K42.08324538
15NTRK11.91059218
16CDK191.90750872
17PLK21.84910575
18BCKDK1.83359726
19MAPK131.77067082
20DAPK21.76619417
21PINK11.74240617
22UHMK11.71996520
23DYRK1B1.67234152
24OBSCN1.63972912
25PAK61.61358304
26PNCK1.58625503
27NTRK21.57883016
28DAPK11.56228906
29DYRK31.51374863
30EPHB21.42111234
31KSR21.41266486
32ARAF1.35579922
33AKT31.34806745
34TNIK1.30854267
35CDK51.30587290
36TSSK61.28995040
37CSNK1G11.27837763
38WNK31.27384588
39DDR21.26357144
40PRKCG1.22312153
41TESK11.21482893
42FRK1.20126206
43PRKD31.17862637
44OXSR11.15914486
45MYLK1.15569768
46KSR11.13509960
47PRPF4B1.13498926
48CSNK1A1L1.13415938
49MAP3K21.13166730
50LIMK11.12840766
51CAMKK21.12697326
52PIM21.09481040
53CAMK2A1.08797763
54EPHA31.07677763
55LATS21.07068580
56PHKG21.02888529
57PHKG11.02888529
58CDK141.01650364
59CSNK1G21.01100413
60RPS6KA41.00961535
61CDK180.98786484
62STK160.97393201
63MAP3K60.97298005
64BCR0.95633633
65GRK70.93561795
66CDK150.93282991
67SGK2230.93179299
68SGK4940.93179299
69CAMK2B0.93028561
70NME10.90790376
71CCNB10.90412576
72PRKCE0.87277182
73RIPK40.86856216
74CDK11A0.82887760
75ADRBK10.82413007
76DYRK1A0.81476882
77PAK30.76413416
78STK390.75007991
79CSNK1G30.74894817
80CAMKK10.74889468
81WNK40.73566649
82ADRBK20.73373210
83RET0.68320232
84PTK2B0.67869704
85GRK10.66857907
86FGFR20.66038429
87SGK20.64491458
88INSRR0.63992128
89FER0.62710474
90CAMK2D0.62638342
91PKN10.60683521
92WNK10.60241300
93PDK40.58597384
94PDK30.58597384
95PDGFRA0.58181090
96DYRK20.56639130
97CAMK2G0.56628104
98MAPKAPK50.56596655
99SIK30.56488264
100BRAF0.56414840
101DAPK30.56299280
102ABL20.56092640
103MAP3K50.55651882
104FGR0.54159369
105CDK30.54046768
106CDK80.51911344
107ROCK10.51101726
108ROCK20.50585452
109MOS0.50226659
110BMPR1B0.49456973
111CAMK10.47357518
112ERBB40.45359017
113NEK10.44018399
114STK38L0.43884148
115BMPR20.43820977
116STK110.43679479
117MAP2K10.42895037
118PRKACA0.42540149
119TYRO30.42145029
120ERBB30.41665579
121LMTK20.40583749
122PLK30.40442391
123STK380.39440691
124PRKG10.39336894
125PRKACB0.38456620
126SIK20.38236488
127CAMK40.37945128
128TGFBR20.37816711
129MKNK10.37222463
130NUAK10.37135913
131CSNK1A10.36956091
132PRKAA10.36817126
133PRKCH0.36603617
134YES10.36258192
135TGFBR10.35499123
136CDC42BPA0.35451348
137RPS6KA30.35413521
138NEK60.35327722
139MAPK100.34957025
140RPS6KA20.34902747
141MUSK0.34878083
142FLT30.31790972
143RPS6KA50.29129440
144MAPK40.28768157

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.82273191
2Nicotine addiction_Homo sapiens_hsa050333.76606465
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.70393216
4GABAergic synapse_Homo sapiens_hsa047272.68823957
5Collecting duct acid secretion_Homo sapiens_hsa049662.55128881
6Olfactory transduction_Homo sapiens_hsa047402.42508485
7Circadian entrainment_Homo sapiens_hsa047132.40361279
8Morphine addiction_Homo sapiens_hsa050322.39459558
9Taste transduction_Homo sapiens_hsa047422.28504585
10Amphetamine addiction_Homo sapiens_hsa050312.28255145
11Dopaminergic synapse_Homo sapiens_hsa047282.23380324
12Oxidative phosphorylation_Homo sapiens_hsa001902.19441973
13Glutamatergic synapse_Homo sapiens_hsa047242.18466019
14Long-term potentiation_Homo sapiens_hsa047202.18278991
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15236412
16Insulin secretion_Homo sapiens_hsa049112.11349473
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.10247576
18Serotonergic synapse_Homo sapiens_hsa047262.06258615
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.96262735
20Steroid biosynthesis_Homo sapiens_hsa001001.94274115
21Vibrio cholerae infection_Homo sapiens_hsa051101.88733464
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.84230296
23Parkinsons disease_Homo sapiens_hsa050121.83154260
24Salivary secretion_Homo sapiens_hsa049701.80214958
25Cocaine addiction_Homo sapiens_hsa050301.76584182
26Cholinergic synapse_Homo sapiens_hsa047251.71639550
27Long-term depression_Homo sapiens_hsa047301.66978185
28Renin secretion_Homo sapiens_hsa049241.58083746
29Fatty acid elongation_Homo sapiens_hsa000621.57869814
30Alzheimers disease_Homo sapiens_hsa050101.52218961
31Cardiac muscle contraction_Homo sapiens_hsa042601.47738804
32Gastric acid secretion_Homo sapiens_hsa049711.43561165
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41337997
34Calcium signaling pathway_Homo sapiens_hsa040201.39897518
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39703443
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37605640
37Gap junction_Homo sapiens_hsa045401.32355432
38Oxytocin signaling pathway_Homo sapiens_hsa049211.26341856
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24446518
40Propanoate metabolism_Homo sapiens_hsa006401.20123876
41Huntingtons disease_Homo sapiens_hsa050161.17336779
42Butanoate metabolism_Homo sapiens_hsa006501.13393017
43GnRH signaling pathway_Homo sapiens_hsa049121.10742556
44Phototransduction_Homo sapiens_hsa047441.10055270
45Axon guidance_Homo sapiens_hsa043601.07567748
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05482172
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05210920
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02795933
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01871456
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98164217
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98110060
52Estrogen signaling pathway_Homo sapiens_hsa049150.96716686
53cAMP signaling pathway_Homo sapiens_hsa040240.96473921
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96253748
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94466817
56Melanogenesis_Homo sapiens_hsa049160.93416906
57Type II diabetes mellitus_Homo sapiens_hsa049300.90864090
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90454396
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88983693
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84459420
61Regulation of autophagy_Homo sapiens_hsa041400.84413582
62ErbB signaling pathway_Homo sapiens_hsa040120.84016237
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.83284692
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83144855
65Oocyte meiosis_Homo sapiens_hsa041140.82421063
66Basal transcription factors_Homo sapiens_hsa030220.81865775
67ECM-receptor interaction_Homo sapiens_hsa045120.79651053
68Hippo signaling pathway_Homo sapiens_hsa043900.78570769
69Alcoholism_Homo sapiens_hsa050340.73835176
70Basal cell carcinoma_Homo sapiens_hsa052170.73816104
71Glioma_Homo sapiens_hsa052140.73039113
72Peroxisome_Homo sapiens_hsa041460.71881493
73Ether lipid metabolism_Homo sapiens_hsa005650.71679680
74Tryptophan metabolism_Homo sapiens_hsa003800.71032038
75Thyroid hormone synthesis_Homo sapiens_hsa049180.70587435
76Sulfur metabolism_Homo sapiens_hsa009200.70504365
77Folate biosynthesis_Homo sapiens_hsa007900.69946721
78Protein digestion and absorption_Homo sapiens_hsa049740.69454926
79Pancreatic secretion_Homo sapiens_hsa049720.66487728
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65728611
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63326976
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.61242972
83beta-Alanine metabolism_Homo sapiens_hsa004100.59308730
84Ras signaling pathway_Homo sapiens_hsa040140.57966942
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57399051
86Hedgehog signaling pathway_Homo sapiens_hsa043400.55397942
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54725140
88Tight junction_Homo sapiens_hsa045300.54711524
89Dorso-ventral axis formation_Homo sapiens_hsa043200.54334879
90Selenocompound metabolism_Homo sapiens_hsa004500.52984147
91MAPK signaling pathway_Homo sapiens_hsa040100.52513365
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52280262
93Circadian rhythm_Homo sapiens_hsa047100.52209060
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52191102
95Rheumatoid arthritis_Homo sapiens_hsa053230.52076034
96Type I diabetes mellitus_Homo sapiens_hsa049400.51679829
97Wnt signaling pathway_Homo sapiens_hsa043100.51223373
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50977136
99Dilated cardiomyopathy_Homo sapiens_hsa054140.50091934
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.48688901
101Glucagon signaling pathway_Homo sapiens_hsa049220.47257006
102Phagosome_Homo sapiens_hsa041450.46334970
103Melanoma_Homo sapiens_hsa052180.45411431
104Choline metabolism in cancer_Homo sapiens_hsa052310.45282298
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45046731
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44841597
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44577319
108Rap1 signaling pathway_Homo sapiens_hsa040150.42450695
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41816110
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41325258
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39481062
112Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38478633
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37590140
114Arginine and proline metabolism_Homo sapiens_hsa003300.37529466
115TGF-beta signaling pathway_Homo sapiens_hsa043500.36720366
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.36344409
117Ovarian steroidogenesis_Homo sapiens_hsa049130.34713915
118Inositol phosphate metabolism_Homo sapiens_hsa005620.34036381
119Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33166078
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33012687
121Metabolic pathways_Homo sapiens_hsa011000.32667341
122Focal adhesion_Homo sapiens_hsa045100.32473188
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32409385
124Colorectal cancer_Homo sapiens_hsa052100.31479276
125Protein export_Homo sapiens_hsa030600.30857179
126Endocytosis_Homo sapiens_hsa041440.30835981
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.30422435
128Insulin signaling pathway_Homo sapiens_hsa049100.29709683
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29001259
130Renal cell carcinoma_Homo sapiens_hsa052110.28921076
131mTOR signaling pathway_Homo sapiens_hsa041500.28733221
132Pyruvate metabolism_Homo sapiens_hsa006200.27075316
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25544711
134Endometrial cancer_Homo sapiens_hsa052130.24129613

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