ARMCX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the armadillo repeat-containing family of proteins, which interact with other proteins in a variety of cellular processes. The function of this family member is currently unknown. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)5.13238491
2presynaptic membrane assembly (GO:0097105)5.00872154
3pyrimidine nucleobase catabolic process (GO:0006208)4.82321289
4synaptic vesicle maturation (GO:0016188)4.60910346
5presynaptic membrane organization (GO:0097090)4.53691978
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.48570012
7locomotory exploration behavior (GO:0035641)4.43731419
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.41250810
9dendritic spine morphogenesis (GO:0060997)4.06882916
10nucleobase catabolic process (GO:0046113)4.03317887
11axonal fasciculation (GO:0007413)3.76685831
12negative regulation of cytosolic calcium ion concentration (GO:0051481)3.75779022
13vocalization behavior (GO:0071625)3.69490294
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.64884880
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.64073460
16establishment of nucleus localization (GO:0040023)3.63056436
17proline transport (GO:0015824)3.61190342
18cell migration in hindbrain (GO:0021535)3.59432544
19neuron recognition (GO:0008038)3.59080723
20exploration behavior (GO:0035640)3.52934624
21synaptic vesicle docking involved in exocytosis (GO:0016081)3.49520389
22glutamate secretion (GO:0014047)3.46185311
23regulation of glutamate receptor signaling pathway (GO:1900449)3.44821061
24pre-miRNA processing (GO:0031054)3.40334849
25synaptic vesicle exocytosis (GO:0016079)3.38908345
26protein localization to synapse (GO:0035418)3.38814350
27dendrite morphogenesis (GO:0048813)3.38199990
28positive regulation of synapse maturation (GO:0090129)3.32756207
29regulation of synaptic vesicle exocytosis (GO:2000300)3.32590866
30cell communication by electrical coupling (GO:0010644)3.22849294
31central nervous system projection neuron axonogenesis (GO:0021952)3.19971658
32neuron cell-cell adhesion (GO:0007158)3.17640710
33activation of protein kinase A activity (GO:0034199)3.11482329
34response to auditory stimulus (GO:0010996)3.08487148
35neuronal action potential propagation (GO:0019227)3.05372253
36cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05272669
37nonmotile primary cilium assembly (GO:0035058)3.04233362
38cerebellar Purkinje cell layer development (GO:0021680)3.02251528
39calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.01215452
40neurotransmitter secretion (GO:0007269)3.00022655
41behavioral response to nicotine (GO:0035095)2.99357652
42innervation (GO:0060384)2.95797901
43regulation of synapse structural plasticity (GO:0051823)2.95144922
44regulation of long-term neuronal synaptic plasticity (GO:0048169)2.95121715
45positive regulation of dendritic spine morphogenesis (GO:0061003)2.93191812
46regulation of neuronal synaptic plasticity (GO:0048168)2.92509827
47positive regulation of action potential (GO:0045760)2.92253848
48behavioral response to ethanol (GO:0048149)2.89728625
49transmission of nerve impulse (GO:0019226)2.85476327
50membrane depolarization during action potential (GO:0086010)2.81980417
51retinal ganglion cell axon guidance (GO:0031290)2.80731285
52neuromuscular process controlling balance (GO:0050885)2.79864687
53ionotropic glutamate receptor signaling pathway (GO:0035235)2.79862734
54limb development (GO:0060173)2.77663872
55appendage development (GO:0048736)2.77663872
56regulation of synaptic vesicle transport (GO:1902803)2.77035278
57regulation of dendritic spine morphogenesis (GO:0061001)2.75776676
58cerebellar Purkinje cell differentiation (GO:0021702)2.75215183
59regulation of action potential (GO:0098900)2.73542796
60dendritic spine organization (GO:0097061)2.72997969
61epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71836401
62cytoskeletal anchoring at plasma membrane (GO:0007016)2.71769649
63urinary tract smooth muscle contraction (GO:0014848)2.68960532
64plasma membrane repair (GO:0001778)2.68285729
65startle response (GO:0001964)2.67828553
66axon extension (GO:0048675)2.66240666
67sodium ion export (GO:0071436)2.66065231
68mechanosensory behavior (GO:0007638)2.66015355
69regulation of respiratory system process (GO:0044065)2.65357015
70regulation of axon extension involved in axon guidance (GO:0048841)2.62603801
71negative regulation of dendrite development (GO:2000171)2.61112747
72regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.61090293
73neurofilament cytoskeleton organization (GO:0060052)2.60728098
74vesicle transport along microtubule (GO:0047496)2.60509294
75cerebellum development (GO:0021549)2.60193711
76negative regulation of axon guidance (GO:1902668)2.59625976
77head development (GO:0060322)2.59521731
78neuronal action potential (GO:0019228)2.56426803
79retinal cone cell development (GO:0046549)2.56242488
80organelle transport along microtubule (GO:0072384)2.54264742
81insulin-like growth factor receptor signaling pathway (GO:0048009)2.53308645
82regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.53118276
83negative regulation of catenin import into nucleus (GO:0035414)2.52639016
84negative regulation of microtubule polymerization (GO:0031115)2.52590217
85synapse organization (GO:0050808)2.52065735
86olfactory bulb development (GO:0021772)2.51967993
87nucleus localization (GO:0051647)2.51018192
88synaptic transmission, glutamatergic (GO:0035249)2.50990211
89clathrin coat assembly (GO:0048268)2.50390939
90positive regulation of dendrite morphogenesis (GO:0050775)2.50324401
91neuromuscular synaptic transmission (GO:0007274)2.49197798
92brain morphogenesis (GO:0048854)2.48956831
93spinal cord development (GO:0021510)2.48944334
94regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.47151217
95negative regulation of synaptic transmission, GABAergic (GO:0032229)2.46808738
96positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.46759626
97negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.46201749
98negative regulation of translation, ncRNA-mediated (GO:0040033)2.46201749
99regulation of translation, ncRNA-mediated (GO:0045974)2.46201749
100membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.46086692
101G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.46080564
102glutamate receptor signaling pathway (GO:0007215)2.45902451
103synaptic vesicle endocytosis (GO:0048488)2.45895120
104body morphogenesis (GO:0010171)2.45576568
105gamma-aminobutyric acid transport (GO:0015812)2.45472818
106regulation of axon guidance (GO:1902667)2.44953147
107membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.44547884
108polarized epithelial cell differentiation (GO:0030859)2.44444753
109inner ear receptor cell development (GO:0060119)2.44375962
110gastrulation with mouth forming second (GO:0001702)2.43871800
111postsynaptic membrane organization (GO:0001941)2.43580216
112righting reflex (GO:0060013)2.42593054
113positive regulation of synapse assembly (GO:0051965)2.42369871
114kidney morphogenesis (GO:0060993)2.42332669
115hippo signaling (GO:0035329)2.42320479
116protein localization to cilium (GO:0061512)2.41502495
117neuronal ion channel clustering (GO:0045161)2.40173264
118apical protein localization (GO:0045176)2.40100489
119regulation of synapse maturation (GO:0090128)2.40054694
120planar cell polarity pathway involved in neural tube closure (GO:0090179)2.39424233
121mating behavior (GO:0007617)2.39260060
122auditory behavior (GO:0031223)2.39145011
123glycosphingolipid biosynthetic process (GO:0006688)2.39108949
124establishment of mitochondrion localization (GO:0051654)2.38981574
125central nervous system neuron axonogenesis (GO:0021955)2.38809443
126regulation of synaptic transmission, GABAergic (GO:0032228)2.37563103
127positive regulation of axon extension (GO:0045773)2.37389945
128long-term memory (GO:0007616)2.37264381
129protein polyglutamylation (GO:0018095)2.37030709
130regulation of NFAT protein import into nucleus (GO:0051532)2.36672295
131glucocorticoid receptor signaling pathway (GO:0042921)2.36318542
132reflex (GO:0060004)2.35909359
133adult walking behavior (GO:0007628)2.35838458
134homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.35581669
135hindbrain development (GO:0030902)2.35200543
136glial cell proliferation (GO:0014009)2.35078800
137regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.34928472
138cellular potassium ion homeostasis (GO:0030007)2.34909585
139neurotransmitter-gated ion channel clustering (GO:0072578)2.34705712
140regulation of cilium movement (GO:0003352)2.32629215
141synapse assembly (GO:0007416)2.32354433
142cochlea development (GO:0090102)2.32165237
143regulation of sarcomere organization (GO:0060297)2.31944362
144stress granule assembly (GO:0034063)2.31886402
145peptidyl-lysine dimethylation (GO:0018027)2.31712042
146positive regulation of dendritic spine development (GO:0060999)2.31361294
147regulation of postsynaptic membrane potential (GO:0060078)2.30306860
148cilium morphogenesis (GO:0060271)2.30258373
149neuron projection extension (GO:1990138)2.30244469
150regulation of glycogen (starch) synthase activity (GO:2000465)2.29812625
151peptidyl-arginine N-methylation (GO:0035246)2.29791475
152peptidyl-arginine methylation (GO:0018216)2.29791475
153negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.29465378
154neuron-neuron synaptic transmission (GO:0007270)2.29433570
155regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.28563205
156negative regulation of sodium ion transport (GO:0010766)2.28552885
157epithelial cilium movement (GO:0003351)2.28521987
158limb bud formation (GO:0060174)2.27904148

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.13440753
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.90643928
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66412834
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64458601
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.54329738
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52328460
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52328460
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.50314226
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45846852
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33021310
11IGF1R_20145208_ChIP-Seq_DFB_Human2.31990906
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31540764
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.31143238
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.24190148
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23651417
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.21415292
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18795852
18TAF15_26573619_Chip-Seq_HEK293_Human2.17642037
19ZFP281_18757296_ChIP-ChIP_E14_Mouse2.15220340
20DROSHA_22980978_ChIP-Seq_HELA_Human2.14085569
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12325093
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11873048
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.10678482
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.10470841
25GBX2_23144817_ChIP-Seq_PC3_Human2.08144763
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05655848
27RARB_27405468_Chip-Seq_BRAIN_Mouse2.05104725
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.04698995
29TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.04336274
30REST_21632747_ChIP-Seq_MESCs_Mouse2.01284163
31MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00561454
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.97101283
33P300_19829295_ChIP-Seq_ESCs_Human1.96234272
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.90855861
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.86898908
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85656529
37VDR_22108803_ChIP-Seq_LS180_Human1.85598840
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84400572
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.82832115
40ZNF274_21170338_ChIP-Seq_K562_Hela1.82072005
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.80613619
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78288805
43ZFP281_27345836_Chip-Seq_ESCs_Mouse1.77238685
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.73631821
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.64779040
46DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.63849629
47RING1B_27294783_Chip-Seq_NPCs_Mouse1.62923311
48SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.61996714
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61913797
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.59791158
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.59031399
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.58903080
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58557174
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.56418064
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.52485888
56KDM2B_26808549_Chip-Seq_K562_Human1.51618320
57AR_25329375_ChIP-Seq_VCAP_Human1.47028286
58AR_21572438_ChIP-Seq_LNCaP_Human1.46442246
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45707431
60EWS_26573619_Chip-Seq_HEK293_Human1.44837927
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43687667
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43576593
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43255226
64HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42627466
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42181936
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40749804
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40611504
68TCF4_23295773_ChIP-Seq_U87_Human1.39492727
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37458382
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36933356
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35439093
72BCAT_22108803_ChIP-Seq_LS180_Human1.34320157
73ISL1_27105846_Chip-Seq_CPCs_Mouse1.32207346
74AR_19668381_ChIP-Seq_PC3_Human1.31677766
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.31458587
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29701486
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29405719
78YAP1_20516196_ChIP-Seq_MESCs_Mouse1.29392496
79RUNX2_22187159_ChIP-Seq_PCA_Human1.28900149
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28584196
81CBP_20019798_ChIP-Seq_JUKART_Human1.28584196
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28557834
83ER_23166858_ChIP-Seq_MCF-7_Human1.27597463
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.26318261
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25924742
86SOX2_21211035_ChIP-Seq_LN229_Gbm1.25846899
87EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25374347
88OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22216722
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20612341
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19550626
91TP53_20018659_ChIP-ChIP_R1E_Mouse1.19121100
92SMAD4_21799915_ChIP-Seq_A2780_Human1.19084327
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18452220
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16852555
95KDM2B_26808549_Chip-Seq_REH_Human1.14432062
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13815494
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13710203
98LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13399335
99FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.13357600
100CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12760928
101KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12645101
102HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10316793
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.09962465
104RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09899547
105TCF4_22108803_ChIP-Seq_LS180_Human1.08749809
106POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08739171
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08479307
108KDM2B_26808549_Chip-Seq_JURKAT_Human1.08242690
109MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08056485
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07497028
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.07053573
112ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06824601
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06723513
114WT1_19549856_ChIP-ChIP_CCG9911_Human1.06354723
115NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05421297
116SMAD3_21741376_ChIP-Seq_EPCs_Human1.05302076
117ARNT_22903824_ChIP-Seq_MCF-7_Human1.04821104
118SMAD4_21741376_ChIP-Seq_EPCs_Human1.04666460
119DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03896441
120NFE2_27457419_Chip-Seq_LIVER_Mouse1.03745829
121P53_22387025_ChIP-Seq_ESCs_Mouse1.03386149
122TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02502279
123KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02356698
124EP300_21415370_ChIP-Seq_HL-1_Mouse1.02006260
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01921003
126IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01619827
127AHR_22903824_ChIP-Seq_MCF-7_Human1.01209293
128KDM2B_26808549_Chip-Seq_DND41_Human0.98160450
129SMAD3_21741376_ChIP-Seq_ESCs_Human0.97971132
130RNF2_27304074_Chip-Seq_NSC_Mouse0.97516959
131STAT3_23295773_ChIP-Seq_U87_Human0.96664199
132TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95403439
133SMAD4_21741376_ChIP-Seq_HESCs_Human0.93931377
134TBX3_20139965_ChIP-Seq_MESCs_Mouse0.93553883
135* FUS_26573619_Chip-Seq_HEK293_Human0.93329011
136TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93195560
137CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93153959
138OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93152031
139TRIM28_21343339_ChIP-Seq_HEK293_Human0.92490735
140PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92387971
141KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91753086
142TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89946524
143BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89814657
144TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89788981
145POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89470907
146TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89470907

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.32615788
2MP0003122_maternal_imprinting3.44095409
3MP0004270_analgesia2.63980152
4MP0003635_abnormal_synaptic_transmissio2.63905861
5MP0003283_abnormal_digestive_organ2.36603485
6MP0001984_abnormal_olfaction2.35926100
7MP0003880_abnormal_central_pattern2.35093274
8MP0003123_paternal_imprinting2.31545197
9MP0001529_abnormal_vocalization2.30463378
10MP0003121_genomic_imprinting2.24168461
11MP0009780_abnormal_chondrocyte_physiolo2.18990696
12MP0000778_abnormal_nervous_system2.14148736
13MP0002063_abnormal_learning/memory/cond2.12193030
14MP0000537_abnormal_urethra_morphology2.02929414
15MP0005423_abnormal_somatic_nervous2.00938137
16MP0002736_abnormal_nociception_after1.99471517
17MP0003787_abnormal_imprinting1.96107515
18MP0005187_abnormal_penis_morphology1.88424573
19MP0004858_abnormal_nervous_system1.77714182
20MP0005623_abnormal_meninges_morphology1.76956140
21MP0009745_abnormal_behavioral_response1.76395711
22MP0004133_heterotaxia1.72509622
23MP0002734_abnormal_mechanical_nocicepti1.67449804
24MP0008877_abnormal_DNA_methylation1.66087103
25MP0002102_abnormal_ear_morphology1.64290128
26MP0002184_abnormal_innervation1.61600579
27MP0002064_seizures1.60562169
28MP0010030_abnormal_orbit_morphology1.56938774
29MP0003119_abnormal_digestive_system1.55527776
30MP0002572_abnormal_emotion/affect_behav1.54725727
31MP0003385_abnormal_body_wall1.54152036
32MP0002638_abnormal_pupillary_reflex1.53946332
33MP0000569_abnormal_digit_pigmentation1.52217278
34MP0005551_abnormal_eye_electrophysiolog1.51529060
35MP0004811_abnormal_neuron_physiology1.50700523
36MP0005253_abnormal_eye_physiology1.48712896
37MP0000955_abnormal_spinal_cord1.47098968
38MP0002822_catalepsy1.47022238
39MP0009046_muscle_twitch1.46493404
40MP0004233_abnormal_muscle_weight1.45750652
41MP0001299_abnormal_eye_distance/1.44149501
42MP0004145_abnormal_muscle_electrophysio1.42178125
43MP0003136_yellow_coat_color1.41404141
44MP0001486_abnormal_startle_reflex1.41384553
45MP0002909_abnormal_adrenal_gland1.40885253
46MP0000751_myopathy1.40430393
47MP0003861_abnormal_nervous_system1.33318417
48MP0005646_abnormal_pituitary_gland1.33078815
49MP0004142_abnormal_muscle_tone1.33016175
50MP0003890_abnormal_embryonic-extraembry1.31889944
51MP0001968_abnormal_touch/_nociception1.30558513
52MP0000534_abnormal_ureter_morphology1.29304616
53MP0004885_abnormal_endolymph1.29076382
54MP0002234_abnormal_pharynx_morphology1.27837128
55MP0003195_calcinosis1.27397293
56MP0002152_abnormal_brain_morphology1.27000608
57MP0005076_abnormal_cell_differentiation1.26390919
58MP0002751_abnormal_autonomic_nervous1.26097349
59MP0002557_abnormal_social/conspecific_i1.26047576
60MP0003942_abnormal_urinary_system1.24060313
61MP0003705_abnormal_hypodermis_morpholog1.23859034
62MP0000631_abnormal_neuroendocrine_gland1.21963672
63MP0002882_abnormal_neuron_morphology1.19463048
64MP0002733_abnormal_thermal_nociception1.18900565
65MP0009053_abnormal_anal_canal1.18083412
66MP0001485_abnormal_pinna_reflex1.17263221
67MP0010386_abnormal_urinary_bladder1.15300719
68MP0004272_abnormal_basement_membrane1.15071077
69MP0000428_abnormal_craniofacial_morphol1.11912470
70MP0005248_abnormal_Harderian_gland1.11906612
71MP0002272_abnormal_nervous_system1.11869849
72MP0002837_dystrophic_cardiac_calcinosis1.11644319
73MP0003633_abnormal_nervous_system1.11113593
74MP0002752_abnormal_somatic_nervous1.10907857
75MP0002067_abnormal_sensory_capabilities1.10295525
76MP0000049_abnormal_middle_ear1.07168366
77MP0003115_abnormal_respiratory_system1.05806387
78MP0003935_abnormal_craniofacial_develop1.05582390
79MP0001905_abnormal_dopamine_level1.05409389
80MP0001440_abnormal_grooming_behavior1.04496589
81MP0002653_abnormal_ependyma_morphology1.04026028
82MP0004924_abnormal_behavior1.03735075
83MP0005386_behavior/neurological_phenoty1.03735075
84MP0005394_taste/olfaction_phenotype1.02927366
85MP0005499_abnormal_olfactory_system1.02927366
86MP0006276_abnormal_autonomic_nervous0.99455769
87MP0008569_lethality_at_weaning0.97605398
88MP0008961_abnormal_basal_metabolism0.97584643
89MP0003755_abnormal_palate_morphology0.96713780
90MP0010234_abnormal_vibrissa_follicle0.96550433
91MP0002081_perinatal_lethality0.96266461
92MP0000026_abnormal_inner_ear0.94178098
93MP0001970_abnormal_pain_threshold0.93737474
94MP0002116_abnormal_craniofacial_bone0.93564950
95MP0001502_abnormal_circadian_rhythm0.93412580
96MP0002066_abnormal_motor_capabilities/c0.93257203
97MP0002084_abnormal_developmental_patter0.93087272
98MP0000013_abnormal_adipose_tissue0.92592745
99MP0004085_abnormal_heartbeat0.91681660
100MP0003137_abnormal_impulse_conducting0.91656397
101MP0004742_abnormal_vestibular_system0.91565899
102MP0003937_abnormal_limbs/digits/tail_de0.90346476
103MP0002735_abnormal_chemical_nociception0.89725322
104MP0001963_abnormal_hearing_physiology0.87719591
105MP0002938_white_spotting0.87372957
106MP0001348_abnormal_lacrimal_gland0.86638988
107MP0001188_hyperpigmentation0.86106979
108MP0003631_nervous_system_phenotype0.85106758
109MP0001177_atelectasis0.84979373
110MP0002233_abnormal_nose_morphology0.84480978
111MP0002932_abnormal_joint_morphology0.84234886
112MP0009250_abnormal_appendicular_skeleto0.84077591
113MP0009672_abnormal_birth_weight0.83738999
114MP0004197_abnormal_fetal_growth/weight/0.82946353
115MP0004215_abnormal_myocardial_fiber0.82917263
116MP0009703_decreased_birth_body0.82192627
117MP0005195_abnormal_posterior_eye0.81749128
118MP0003938_abnormal_ear_development0.81582257
119MP0010368_abnormal_lymphatic_system0.81222293
120MP0002069_abnormal_eating/drinking_beha0.80818566
121MP0002089_abnormal_postnatal_growth/wei0.79863129
122MP0008789_abnormal_olfactory_epithelium0.79669424
123MP0006072_abnormal_retinal_apoptosis0.79181496
124MP0004084_abnormal_cardiac_muscle0.79031480
125MP0003567_abnormal_fetal_cardiomyocyte0.79005404
126MP0002229_neurodegeneration0.78696415
127MP0000733_abnormal_muscle_development0.78262176
128MP0001501_abnormal_sleep_pattern0.77649866
129MP0005645_abnormal_hypothalamus_physiol0.76665776
130MP0001943_abnormal_respiration0.76260295
131MP0003011_delayed_dark_adaptation0.75747909
132MP0002085_abnormal_embryonic_tissue0.74424063
133MP0006292_abnormal_olfactory_placode0.74264517
134MP0001986_abnormal_taste_sensitivity0.73967903
135MP0001849_ear_inflammation0.72404579
136MP0005391_vision/eye_phenotype0.72207689
137MP0005503_abnormal_tendon_morphology0.71329096
138MP0002928_abnormal_bile_duct0.70651448
139MP0003632_abnormal_nervous_system0.70114568

Predicted human phenotypes

RankGene SetZ-score
1Intestinal atresia (HP:0011100)3.42707771
2Gait imbalance (HP:0002141)3.24580911
3Hyperventilation (HP:0002883)3.18002405
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.15791574
5Short 4th metacarpal (HP:0010044)3.15791574
6Renal duplication (HP:0000075)3.11554646
7Medial flaring of the eyebrow (HP:0010747)3.10866402
8Pancreatic fibrosis (HP:0100732)3.10202099
9True hermaphroditism (HP:0010459)3.04356819
10Pancreatic cysts (HP:0001737)3.02729465
11Nephronophthisis (HP:0000090)2.98450121
12Congenital primary aphakia (HP:0007707)2.88182583
13Visual hallucinations (HP:0002367)2.86689965
14Myokymia (HP:0002411)2.86026711
15Gaze-evoked nystagmus (HP:0000640)2.83029818
16Hyperacusis (HP:0010780)2.80062564
17Abnormality of midbrain morphology (HP:0002418)2.78106629
18Molar tooth sign on MRI (HP:0002419)2.78106629
19Polyphagia (HP:0002591)2.70317621
20Insomnia (HP:0100785)2.69247983
21Genital tract atresia (HP:0001827)2.68744235
22Nephrogenic diabetes insipidus (HP:0009806)2.67832066
23Focal seizures (HP:0007359)2.65859937
24Hepatoblastoma (HP:0002884)2.64755414
25Elfin facies (HP:0004428)2.64392660
26Vaginal atresia (HP:0000148)2.62049546
27Abnormality of the lower motor neuron (HP:0002366)2.56713768
28Abnormality of the 4th metacarpal (HP:0010012)2.55276181
29Focal motor seizures (HP:0011153)2.53027242
30Shallow orbits (HP:0000586)2.51853620
31Chronic hepatic failure (HP:0100626)2.50994214
32Abnormality of the renal medulla (HP:0100957)2.45745267
33Renovascular hypertension (HP:0100817)2.43977366
34Macroorchidism (HP:0000053)2.41515256
35Pointed chin (HP:0000307)2.41243637
36Overriding aorta (HP:0002623)2.40151662
37Absent speech (HP:0001344)2.35709436
38Termporal pattern (HP:0011008)2.33114986
39Insidious onset (HP:0003587)2.33114986
40Thyroid-stimulating hormone excess (HP:0002925)2.30951433
41Papilledema (HP:0001085)2.24535389
42Neoplasm of the heart (HP:0100544)2.23873436
43Limb dystonia (HP:0002451)2.23477524
44Action tremor (HP:0002345)2.23291511
45Specific learning disability (HP:0001328)2.22754959
46Poor coordination (HP:0002370)2.20344725
47Protruding tongue (HP:0010808)2.20272312
48Epileptiform EEG discharges (HP:0011182)2.18262040
49Genetic anticipation (HP:0003743)2.17746281
50Cystic liver disease (HP:0006706)2.14956191
51Sacral dimple (HP:0000960)2.14632313
52Hypothermia (HP:0002045)2.13776583
53Postaxial hand polydactyly (HP:0001162)2.13520421
54Progressive cerebellar ataxia (HP:0002073)2.13286049
55Abnormality of the astrocytes (HP:0100707)2.12124552
56Astrocytoma (HP:0009592)2.12124552
57Epileptic encephalopathy (HP:0200134)2.08436430
58Flat cornea (HP:0007720)2.08425449
59Amyotrophic lateral sclerosis (HP:0007354)2.07779169
60Pachygyria (HP:0001302)2.06827399
61Lissencephaly (HP:0001339)2.05039742
62Drooling (HP:0002307)2.04747968
63Excessive salivation (HP:0003781)2.04747968
64Short foot (HP:0001773)2.04676035
65Bowel diverticulosis (HP:0005222)2.04497448
66Ankyloglossia (HP:0010296)2.04188189
67Impaired vibration sensation in the lower limbs (HP:0002166)2.00724550
68Abnormal eating behavior (HP:0100738)1.99641057
69Abnormality of the diencephalon (HP:0010662)1.99455395
70Subacute progressive viral hepatitis (HP:0006572)1.98988459
71Ankle clonus (HP:0011448)1.98973649
72Occipital encephalocele (HP:0002085)1.97903174
73Shoulder girdle muscle weakness (HP:0003547)1.97821379
74Inability to walk (HP:0002540)1.95328483
75Aqueductal stenosis (HP:0002410)1.94394810
76Optic nerve hypoplasia (HP:0000609)1.94342362
77Cutaneous finger syndactyly (HP:0010554)1.94230974
78Abnormal drinking behavior (HP:0030082)1.93017585
79Polydipsia (HP:0001959)1.93017585
80Broad foot (HP:0001769)1.92261476
81Depression (HP:0000716)1.92124874
82Urinary bladder sphincter dysfunction (HP:0002839)1.91516969
83Increased nuchal translucency (HP:0010880)1.91455392
84Obsessive-compulsive behavior (HP:0000722)1.91198463
85Bladder diverticulum (HP:0000015)1.90882799
86Buphthalmos (HP:0000557)1.90669450
87Anencephaly (HP:0002323)1.88618265
88Aplasia/Hypoplasia of the tibia (HP:0005772)1.87461839
89Asymmetry of the thorax (HP:0001555)1.87049219
90Lymphangioma (HP:0100764)1.85708608
91Volvulus (HP:0002580)1.85399119
92Postaxial foot polydactyly (HP:0001830)1.85310894
93Absence seizures (HP:0002121)1.84591857
94Increased corneal curvature (HP:0100692)1.84125178
95Keratoconus (HP:0000563)1.84125178
96Megalencephaly (HP:0001355)1.83945961
97Abnormality of the aortic arch (HP:0012303)1.83934383
98Gastrointestinal atresia (HP:0002589)1.83092604
99Enlarged penis (HP:0000040)1.83088587
100Exotropia (HP:0000577)1.82727077
101Atonic seizures (HP:0010819)1.80600312
102Narrow forehead (HP:0000341)1.80205757
103Agitation (HP:0000713)1.79899731
104Urinary urgency (HP:0000012)1.77593920
105Cutaneous syndactyly (HP:0012725)1.77499365
106Broad-based gait (HP:0002136)1.76927073
107Abnormality of the ischium (HP:0003174)1.76374012
108Oligodactyly (hands) (HP:0001180)1.76255000
109Aplasia/Hypoplasia of the lens (HP:0008063)1.75445900
110Poor eye contact (HP:0000817)1.74979173
111Abnormal hair whorl (HP:0010721)1.73294937
112Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72628200
113Midline defect of the nose (HP:0004122)1.72442156
114Sclerocornea (HP:0000647)1.72350444
115Amblyopia (HP:0000646)1.71733112
116Distal arthrogryposis (HP:0005684)1.70497967
117Abnormality of the renal cortex (HP:0011035)1.69803947
118Renal hypoplasia (HP:0000089)1.69232035
119Type II lissencephaly (HP:0007260)1.69209089
120Broad thumb (HP:0011304)1.68974134
121Supranuclear gaze palsy (HP:0000605)1.68730249
122Tubular atrophy (HP:0000092)1.68640536
123Hemiparesis (HP:0001269)1.68118574
124Shawl scrotum (HP:0000049)1.67843231
125Inappropriate behavior (HP:0000719)1.67425839
126Hypoventilation (HP:0002791)1.66882393
127Trigonocephaly (HP:0000243)1.66108350
128Abnormality of the corticospinal tract (HP:0002492)1.64132594
129Megalocornea (HP:0000485)1.63949379
130Lower limb muscle weakness (HP:0007340)1.63853475
131Cerebral aneurysm (HP:0004944)1.62988586
132Impaired social interactions (HP:0000735)1.62791285
133Abnormal social behavior (HP:0012433)1.62791285
134Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.62722049
135Labial hypoplasia (HP:0000066)1.62634099
136Overgrowth (HP:0001548)1.62230051
137Aplasia/Hypoplasia of the tongue (HP:0010295)1.61613882
138Deviation of the hallux (HP:0010051)1.60540738
139Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.59891216
140Generalized tonic-clonic seizures (HP:0002069)1.59729529
141Bronchomalacia (HP:0002780)1.58774638
142Hypoplastic ischia (HP:0003175)1.58641600
143Abnormality of the labia minora (HP:0012880)1.58583606
144Spastic gait (HP:0002064)1.58325189
145Congenital stationary night blindness (HP:0007642)1.57796753
146Hypoplasia of the brainstem (HP:0002365)1.57395084
147Aplasia/Hypoplasia of the brainstem (HP:0007362)1.57395084
148Impaired smooth pursuit (HP:0007772)1.56562425
149Papillary thyroid carcinoma (HP:0002895)1.56312358
150Glioma (HP:0009733)1.56282957
151Febrile seizures (HP:0002373)1.55380268
152Pelvic girdle muscle weakness (HP:0003749)1.54460818
153Hallux valgus (HP:0001822)1.54183014
154Ependymoma (HP:0002888)1.53300715
155Apathy (HP:0000741)1.52981282
156Abnormality of oral frenula (HP:0000190)1.52951769
157Hemiplegia (HP:0002301)1.52930036
158Omphalocele (HP:0001539)1.52527856
159Truncal ataxia (HP:0002078)1.52206724
160Turricephaly (HP:0000262)1.51796107
161Annular pancreas (HP:0001734)1.51685773
162Intellectual disability, profound (HP:0002187)1.49518455
163Dialeptic seizures (HP:0011146)1.48254411
164EEG with generalized epileptiform discharges (HP:0011198)1.47639129
165Short 1st metacarpal (HP:0010034)1.47361288
166Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.47361288
167Dysdiadochokinesis (HP:0002075)1.47069483
168Hypsarrhythmia (HP:0002521)1.46317978

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.56206503
2MARK14.40444266
3CASK3.87912402
4NTRK33.07836571
5MAP3K93.05017913
6MAP3K42.52557048
7TNIK2.48680664
8PINK12.36611189
9LATS22.25737074
10PRKD32.23492145
11MINK12.18441293
12PAK62.17852843
13BMPR1B2.02906121
14NTRK22.01447102
15MAP4K21.98580557
16KSR11.90254649
17EPHA41.83984262
18PKN21.80056386
19BCR1.78145206
20PNCK1.70926771
21PDGFRA1.68724558
22TYRO31.66377966
23UHMK11.62770446
24SIK21.62759569
25ERBB31.56392850
26KSR21.54157093
27TRIB31.52007981
28TIE11.50445449
29DAPK21.49669639
30NTRK11.48963242
31RIPK11.45632117
32ADRBK21.45547962
33EPHB21.43060520
34DDR21.41638863
35MAP2K41.38922602
36SGK21.33775286
37MKNK21.33365764
38ALK1.32742002
39PHKG21.30975533
40PHKG11.30975533
41SCYL21.30652042
42SGK2231.28724571
43SGK4941.28724571
44CAMKK11.28541201
45MAPK131.26940932
46AKT31.26176187
47INSRR1.24063912
48MAP2K71.23149606
49ICK1.22802996
50STK38L1.22507110
51CAMK1G1.21592912
52LATS11.20883114
53GRK11.15537233
54PLK21.12809568
55MAP3K101.12790303
56RET1.10424621
57NEK11.10042563
58TRIM281.08835113
59FGFR21.08826306
60CDK51.08582248
61CDK191.05623777
62PAK31.04720873
63CDC42BPA1.04208998
64PRKCE1.02184647
65STK381.01078330
66FGFR10.96363652
67NUAK10.96351419
68CSNK1G20.95231241
69EPHA30.95183914
70OXSR10.94201493
71CDK140.92374956
72CDK120.91427990
73CDK150.91403161
74MAP3K20.90001049
75CDK180.89540368
76PRKCH0.86769059
77CDC70.83938513
78STK110.82125079
79EEF2K0.80328567
80CDK11A0.79859458
81CAMK10.77798230
82DMPK0.76722475
83DAPK10.76320146
84ACVR1B0.76104064
85PTK60.74547389
86TAOK10.72004221
87CSNK1A1L0.70231724
88CDK30.68497565
89PKN10.68301289
90PRKCG0.68290520
91OBSCN0.67420190
92FER0.66836222
93MTOR0.63326540
94ERBB20.63124158
95LIMK10.62029997
96DYRK1A0.61532034
97ADRBK10.61248192
98RPS6KA20.60892831
99DYRK30.60315820
100MARK20.59311862
101GRK50.59284831
102MAPK150.56995205
103PAK20.56943357
104CSNK1G30.56671556
105MAPK100.54800571
106PLK30.54001238
107PDGFRB0.53996588
108NLK0.53803779
109DYRK20.53444298
110PTK20.53146920
111LMTK20.52844427
112PRKG10.51923978
113PRKAA10.51213183
114RPS6KA30.50667679
115CSNK1E0.50502935
116CSNK1A10.50170355
117CAMK1D0.49954031
118MAP3K70.49216113
119ROCK10.48724026
120PRPF4B0.47013820
121STK390.46352750
122CSNK1D0.46031659
123PRKDC0.45914692
124BRD40.45493323
125SGK10.45315212
126CAMK2A0.45029030
127WNK30.45021201
128MAPK90.44805502
129CAMK40.43620345
130MKNK10.42989565
131PASK0.42963699
132PRKACA0.42893397
133PRKCZ0.42639165
134GSK3B0.42459301
135TGFBR10.41142675
136PRKACB0.41130283
137MAPK80.39646482
138PTK2B0.39577780
139WNK10.39574625
140SGK30.38697581
141CSNK1G10.37685032
142MAP3K60.37152480
143HIPK20.36755769
144CAMK2B0.34973565
145ROCK20.34371470
146WNK40.33744435
147MYLK0.28825933
148CAMKK20.25702256

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.42063874
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.39145046
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.26138894
4Circadian entrainment_Homo sapiens_hsa047132.12293612
5Long-term potentiation_Homo sapiens_hsa047202.07942724
6Butanoate metabolism_Homo sapiens_hsa006502.06473169
7GABAergic synapse_Homo sapiens_hsa047272.06287335
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.05968722
9Synaptic vesicle cycle_Homo sapiens_hsa047212.05510791
10Phototransduction_Homo sapiens_hsa047442.00630206
11Dopaminergic synapse_Homo sapiens_hsa047281.91178347
12Glutamatergic synapse_Homo sapiens_hsa047241.88026960
13Amphetamine addiction_Homo sapiens_hsa050311.86001083
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.82661006
15Insulin secretion_Homo sapiens_hsa049111.81829505
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.80292145
17Olfactory transduction_Homo sapiens_hsa047401.76108972
18Morphine addiction_Homo sapiens_hsa050321.73737183
19Axon guidance_Homo sapiens_hsa043601.73359061
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.62363923
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60691978
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60626969
23Cholinergic synapse_Homo sapiens_hsa047251.59342824
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56557066
25Type II diabetes mellitus_Homo sapiens_hsa049301.54505470
26Gap junction_Homo sapiens_hsa045401.49871320
27Cocaine addiction_Homo sapiens_hsa050301.49299566
28Basal cell carcinoma_Homo sapiens_hsa052171.45928900
29Gastric acid secretion_Homo sapiens_hsa049711.45146856
30Estrogen signaling pathway_Homo sapiens_hsa049151.44198940
31Oxytocin signaling pathway_Homo sapiens_hsa049211.44117796
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.43810823
33Glioma_Homo sapiens_hsa052141.43606481
34Melanogenesis_Homo sapiens_hsa049161.43228811
35Hedgehog signaling pathway_Homo sapiens_hsa043401.42375951
36Long-term depression_Homo sapiens_hsa047301.38809024
37Renin secretion_Homo sapiens_hsa049241.38543839
38Salivary secretion_Homo sapiens_hsa049701.38201302
39GnRH signaling pathway_Homo sapiens_hsa049121.36931213
40Oocyte meiosis_Homo sapiens_hsa041141.33842694
41Hippo signaling pathway_Homo sapiens_hsa043901.33348434
42Dilated cardiomyopathy_Homo sapiens_hsa054141.30594084
43mTOR signaling pathway_Homo sapiens_hsa041501.24335969
44Endometrial cancer_Homo sapiens_hsa052131.23006279
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21637865
46Taste transduction_Homo sapiens_hsa047421.21163112
47Wnt signaling pathway_Homo sapiens_hsa043101.21150190
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19439769
49ErbB signaling pathway_Homo sapiens_hsa040121.18420260
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.16463711
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16280679
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15466718
53Dorso-ventral axis formation_Homo sapiens_hsa043201.15346626
54Serotonergic synapse_Homo sapiens_hsa047261.14962265
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12889767
56Colorectal cancer_Homo sapiens_hsa052101.12808165
57Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09661467
58cAMP signaling pathway_Homo sapiens_hsa040241.08283888
59Protein export_Homo sapiens_hsa030601.04035606
60Calcium signaling pathway_Homo sapiens_hsa040201.03938625
61Ether lipid metabolism_Homo sapiens_hsa005651.03931011
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02412218
63Neurotrophin signaling pathway_Homo sapiens_hsa047221.00587446
64Propanoate metabolism_Homo sapiens_hsa006401.00085139
65Linoleic acid metabolism_Homo sapiens_hsa005910.97136817
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97026841
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95523972
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.94462890
69Tight junction_Homo sapiens_hsa045300.93954073
70Renal cell carcinoma_Homo sapiens_hsa052110.93619238
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92245599
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91833529
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90794134
74Selenocompound metabolism_Homo sapiens_hsa004500.90733781
75Regulation of autophagy_Homo sapiens_hsa041400.90682527
76Ovarian steroidogenesis_Homo sapiens_hsa049130.90375213
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88533121
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87743681
79ABC transporters_Homo sapiens_hsa020100.87095570
80beta-Alanine metabolism_Homo sapiens_hsa004100.86538316
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.86411963
82Proteoglycans in cancer_Homo sapiens_hsa052050.86198073
83Glucagon signaling pathway_Homo sapiens_hsa049220.85365195
84Adherens junction_Homo sapiens_hsa045200.85343620
85Focal adhesion_Homo sapiens_hsa045100.85131350
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84525458
87Nitrogen metabolism_Homo sapiens_hsa009100.84057958
88Tryptophan metabolism_Homo sapiens_hsa003800.82108535
89MAPK signaling pathway_Homo sapiens_hsa040100.82102318
90Rap1 signaling pathway_Homo sapiens_hsa040150.81458969
91Thyroid hormone synthesis_Homo sapiens_hsa049180.81220733
92Insulin signaling pathway_Homo sapiens_hsa049100.81007835
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80318047
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.80063991
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78335717
96mRNA surveillance pathway_Homo sapiens_hsa030150.78092367
97VEGF signaling pathway_Homo sapiens_hsa043700.77648239
98Alcoholism_Homo sapiens_hsa050340.77251460
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76890929
100Non-small cell lung cancer_Homo sapiens_hsa052230.76771573
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.76134920
102MicroRNAs in cancer_Homo sapiens_hsa052060.75718100
103Chronic myeloid leukemia_Homo sapiens_hsa052200.75111185
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74263130
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73309311
106Collecting duct acid secretion_Homo sapiens_hsa049660.72472706
107Cardiac muscle contraction_Homo sapiens_hsa042600.70681379
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68925554
109Choline metabolism in cancer_Homo sapiens_hsa052310.67619142
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67040704
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65366465
112Lysine degradation_Homo sapiens_hsa003100.64935011
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64555495
114Ras signaling pathway_Homo sapiens_hsa040140.62705876
115AMPK signaling pathway_Homo sapiens_hsa041520.61728171
116Notch signaling pathway_Homo sapiens_hsa043300.59582182
117Protein digestion and absorption_Homo sapiens_hsa049740.59349939
118Steroid biosynthesis_Homo sapiens_hsa001000.59278742
119Caffeine metabolism_Homo sapiens_hsa002320.58887280
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58873931
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58658799
122TGF-beta signaling pathway_Homo sapiens_hsa043500.57121540
123Bladder cancer_Homo sapiens_hsa052190.56334380
124Melanoma_Homo sapiens_hsa052180.55734088
125Viral myocarditis_Homo sapiens_hsa054160.54866698
126Pancreatic secretion_Homo sapiens_hsa049720.53730255
127Pathways in cancer_Homo sapiens_hsa052000.52023782
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51283999
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50500350
130Prion diseases_Homo sapiens_hsa050200.49992668
131Endocytosis_Homo sapiens_hsa041440.49959741
132Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49444214
133Prolactin signaling pathway_Homo sapiens_hsa049170.48712605
134Circadian rhythm_Homo sapiens_hsa047100.47414444
135Peroxisome_Homo sapiens_hsa041460.47383376
136Retinol metabolism_Homo sapiens_hsa008300.43615183
137Steroid hormone biosynthesis_Homo sapiens_hsa001400.38329018
138ECM-receptor interaction_Homo sapiens_hsa045120.37172760
139Bile secretion_Homo sapiens_hsa049760.35512938

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