ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	6.05603046
2	establishment of protein localization to mitochondrial membrane (GO:0090151)	6.00718675
3	translational termination (GO:0006415)	5.82225317
4	protein neddylation (GO:0045116)	5.52706537
5	ribosomal small subunit assembly (GO:0000028)	5.38452180
6	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	5.05539734
7	substrate-independent telencephalic tangential migration (GO:0021826)	5.05539734
8	chaperone-mediated protein transport (GO:0072321)	5.02970561
9	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.01080015
10	cotranslational protein targeting to membrane (GO:0006613)	4.98243043
11	ribosomal small subunit biogenesis (GO:0042274)	4.97918910
12	protein targeting to ER (GO:0045047)	4.90523444
13	ATP synthesis coupled proton transport (GO:0015986)	4.88218966
14	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.88218966
15	translational elongation (GO:0006414)	4.74940860
16	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.70460855
17	protein localization to endoplasmic reticulum (GO:0070972)	4.66294760
18	behavioral response to nicotine (GO:0035095)	4.65735593
19	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.51839753
20	protein complex biogenesis (GO:0070271)	4.49783461
21	maturation of SSU-rRNA (GO:0030490)	4.46257590
22	cellular protein complex disassembly (GO:0043624)	4.43218657
23	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.41296585
24	viral life cycle (GO:0019058)	4.32068780
25	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.31359268
26	NADH dehydrogenase complex assembly (GO:0010257)	4.31359268
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.31359268
28	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.23618570
29	cell proliferation in forebrain (GO:0021846)	4.10689363
30	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.08268999
31	mitochondrial respiratory chain complex assembly (GO:0033108)	4.00797002
32	translational initiation (GO:0006413)	3.78773741
33	protein complex disassembly (GO:0043241)	3.77286727
34	respiratory electron transport chain (GO:0022904)	3.73550743
35	pattern specification involved in kidney development (GO:0061004)	3.69983726
36	electron transport chain (GO:0022900)	3.68866189
37	macromolecular complex disassembly (GO:0032984)	3.61968796
38	epithelial cilium movement (GO:0003351)	3.55433105
39	neuron fate determination (GO:0048664)	3.51065315
40	pyrimidine nucleobase catabolic process (GO:0006208)	3.50270713
41	positive regulation of T cell apoptotic process (GO:0070234)	3.37125027
42	intraciliary transport (GO:0042073)	3.36671792
43	translation (GO:0006412)	3.31350344
44	GTP biosynthetic process (GO:0006183)	3.31011859
45	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.30060202
46	protein targeting to membrane (GO:0006612)	3.29210891
47	nonmotile primary cilium assembly (GO:0035058)	3.26151895
48	cerebral cortex radially oriented cell migration (GO:0021799)	3.23263152
49	ribosomal large subunit biogenesis (GO:0042273)	3.20334808
50	somite development (GO:0061053)	3.19241168
51	short-term memory (GO:0007614)	3.16291504
52	pyrimidine nucleotide catabolic process (GO:0006244)	3.02734825
53	protein polyglutamylation (GO:0018095)	2.99866750
54	regulation of cilium movement (GO:0003352)	2.95598768
55	response to pheromone (GO:0019236)	2.92962564
56	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.92900301
57	negative regulation of appetite (GO:0032099)	2.92099512
58	negative regulation of response to food (GO:0032096)	2.92099512
59	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.92085297
60	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.91070134
61	water-soluble vitamin biosynthetic process (GO:0042364)	2.89994819
62	intracellular protein transmembrane import (GO:0044743)	2.89699551
63	axonemal dynein complex assembly (GO:0070286)	2.89429747
64	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.88948697
65	sequestering of actin monomers (GO:0042989)	2.88052618
66	cellular component biogenesis (GO:0044085)	2.88011352
67	head development (GO:0060322)	2.81149189
68	ATP biosynthetic process (GO:0006754)	2.79792698
69	protein-cofactor linkage (GO:0018065)	2.79757846
70	retinal ganglion cell axon guidance (GO:0031290)	2.77075048
71	cilium movement (GO:0003341)	2.76427970
72	hypothalamus development (GO:0021854)	2.76311933
73	segment specification (GO:0007379)	2.74860311
74	hydrogen ion transmembrane transport (GO:1902600)	2.74133180
75	spinal cord association neuron differentiation (GO:0021527)	2.70959426
76	mRNA catabolic process (GO:0006402)	2.70875142
77	UTP biosynthetic process (GO:0006228)	2.70763170
78	parturition (GO:0007567)	2.69938216
79	transmission of nerve impulse (GO:0019226)	2.69656469
80	nucleobase catabolic process (GO:0046113)	2.69137237
81	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.68152137
82	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.63281974
83	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.63281974
84	behavioral response to ethanol (GO:0048149)	2.61501820
85	kinetochore assembly (GO:0051382)	2.61071935
86	cytochrome complex assembly (GO:0017004)	2.60821533
87	axon ensheathment in central nervous system (GO:0032291)	2.59652094
88	central nervous system myelination (GO:0022010)	2.59652094
89	establishment of protein localization to mitochondrion (GO:0072655)	2.59223118
90	UTP metabolic process (GO:0046051)	2.59096185
91	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.58827950
92	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.58827950
93	motile cilium assembly (GO:0044458)	2.58727633
94	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.57048685
95	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.56353281
96	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.53710659
97	synaptic transmission, dopaminergic (GO:0001963)	2.53578761
98	synaptic transmission, cholinergic (GO:0007271)	2.52389266
99	positive regulation of lymphocyte apoptotic process (GO:0070230)	2.52333235
100	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.50677773

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.61530994
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.20084300
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.19763351
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.12993525
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.76843523
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.75488552
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.58526810
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.55445528
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.50036082
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.26280049
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.21124708
12	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.16422793
13	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.08862253
14	VDR_22108803_ChIP-Seq_LS180_Human	2.00741585
15	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.97321876
16	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.92467663
17	ZNF274_21170338_ChIP-Seq_K562_Hela	1.92189710
18	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.89436293
19	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.88660621
20	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.84379749
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.83899448
22	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.80928952
23	REST_21632747_ChIP-Seq_MESCs_Mouse	1.75760106
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.74597967
25	RNF2_27304074_Chip-Seq_NSC_Mouse	1.68303339
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.62116431
27	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.61615141
28	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.56850236
29	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.53059335
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.52517846
31	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.51529059
32	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.49269815
33	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.49195260
34	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.48691366
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48446149
36	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.48386014
37	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.48197396
38	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.48027900
39	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.43153563
40	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.41579730
41	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.39254391
42	EWS_26573619_Chip-Seq_HEK293_Human	1.38705351
43	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.38566401
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.38144283
45	ELK1_19687146_ChIP-ChIP_HELA_Human	1.37032707
46	IGF1R_20145208_ChIP-Seq_DFB_Human	1.36233501
47	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.30428664
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30040555
49	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.29775266
50	VDR_23849224_ChIP-Seq_CD4+_Human	1.29178829
51	FUS_26573619_Chip-Seq_HEK293_Human	1.28026775
52	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.27965833
53	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.27582215
54	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.25799164
55	TTF2_22483619_ChIP-Seq_HELA_Human	1.25726114
56	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.23495173
57	TP53_22573176_ChIP-Seq_HFKS_Human	1.22953143
58	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.20296669
59	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.20006435
60	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.17931983
61	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.17931983
62	XRN2_22483619_ChIP-Seq_HELA_Human	1.17677352
63	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.17433391
64	GABP_19822575_ChIP-Seq_HepG2_Human	1.15783006
65	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.14582772
66	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.13667641
67	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.11700666
68	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.11319951
69	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.11118167
70	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.10858682
71	GBX2_23144817_ChIP-Seq_PC3_Human	1.09681531
72	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09473070
73	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.08906196
74	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.07660634
75	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06959099
76	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.06131820
77	P300_19829295_ChIP-Seq_ESCs_Human	1.05848195
78	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.05150829
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04765171
80	FOXP3_21729870_ChIP-Seq_TREG_Human	1.03672241
81	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.02914177
82	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.02635675
83	NCOR_22424771_ChIP-Seq_293T_Human	1.00836611
84	ERA_21632823_ChIP-Seq_H3396_Human	1.00592591
85	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.99403948
86	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.99286992
87	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.98302858
88	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.96856339
89	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.95779695
90	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93974878
91	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.93974878
92	CBP_20019798_ChIP-Seq_JUKART_Human	0.93378690
93	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.93378690
94	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.92382156
95	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.91607439
96	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.88267357
97	TAF2_19829295_ChIP-Seq_ESCs_Human	0.86648474
98	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.85964161
99	NANOG_20526341_ChIP-Seq_ESCs_Human	0.85462484
100	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	0.85287503

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.44889625
2	MP0006292_abnormal_olfactory_placode	4.34785413
3	MP0003880_abnormal_central_pattern	3.28837736
4	MP0003787_abnormal_imprinting	3.19264465
5	MP0002837_dystrophic_cardiac_calcinosis	3.09675401
6	MP0002653_abnormal_ependyma_morphology	2.81933444
7	MP0008789_abnormal_olfactory_epithelium	2.75904852
8	MP0003123_paternal_imprinting	2.48771704
9	MP0005499_abnormal_olfactory_system	2.45420269
10	MP0005394_taste/olfaction_phenotype	2.45420269
11	MP0003136_yellow_coat_color	2.44121275
12	MP0003646_muscle_fatigue	2.33485317
13	MP0003122_maternal_imprinting	2.18403760
14	MP0002163_abnormal_gland_morphology	2.17258245
15	MP0000778_abnormal_nervous_system	2.12217033
16	MP0006276_abnormal_autonomic_nervous	2.07467528
17	MP0003121_genomic_imprinting	2.00026557
18	MP0001293_anophthalmia	1.83565061
19	MP0008877_abnormal_DNA_methylation	1.82900985
20	MP0001529_abnormal_vocalization	1.81868511
21	MP0002638_abnormal_pupillary_reflex	1.80668345
22	MP0004142_abnormal_muscle_tone	1.76361400
23	MP0004885_abnormal_endolymph	1.75512040
24	MP0003878_abnormal_ear_physiology	1.72473531
25	MP0005377_hearing/vestibular/ear_phenot	1.72473531
26	MP0001485_abnormal_pinna_reflex	1.68897058
27	MP0000631_abnormal_neuroendocrine_gland	1.56377419
28	MP0005646_abnormal_pituitary_gland	1.55034257
29	MP0002272_abnormal_nervous_system	1.43681409
30	MP0001984_abnormal_olfaction	1.42287179
31	MP0004133_heterotaxia	1.41145338
32	MP0001188_hyperpigmentation	1.40444358
33	MP0000049_abnormal_middle_ear	1.39475554
34	MP0005551_abnormal_eye_electrophysiolog	1.38637850
35	MP0002938_white_spotting	1.38542226
36	MP0000372_irregular_coat_pigmentation	1.37776908
37	MP0002160_abnormal_reproductive_system	1.37712465
38	MP0003011_delayed_dark_adaptation	1.32741422
39	MP0002102_abnormal_ear_morphology	1.32372228
40	MP0005389_reproductive_system_phenotype	1.30556441
41	MP0002557_abnormal_social/conspecific_i	1.29798566
42	MP0004147_increased_porphyrin_level	1.29001689
43	MP0001905_abnormal_dopamine_level	1.28732513
44	MP0003879_abnormal_hair_cell	1.28655679
45	MP0004742_abnormal_vestibular_system	1.27061395
46	MP0000026_abnormal_inner_ear	1.26848471
47	MP0001919_abnormal_reproductive_system	1.26214695
48	MP0000955_abnormal_spinal_cord	1.25623362
49	MP0008995_early_reproductive_senescence	1.24668657
50	MP0005379_endocrine/exocrine_gland_phen	1.20997886
51	MP0003938_abnormal_ear_development	1.20650083
52	MP0005084_abnormal_gallbladder_morpholo	1.20099656
53	MP0008775_abnormal_heart_ventricle	1.20089853
54	MP0005423_abnormal_somatic_nervous	1.20004593
55	MP0002822_catalepsy	1.18908043
56	MP0002184_abnormal_innervation	1.18390914
57	MP0002733_abnormal_thermal_nociception	1.17892714
58	MP0002234_abnormal_pharynx_morphology	1.17826536
59	MP0006072_abnormal_retinal_apoptosis	1.16511139
60	MP0009745_abnormal_behavioral_response	1.15872185
61	MP0001968_abnormal_touch/_nociception	1.15582538
62	MP0005195_abnormal_posterior_eye	1.14922061
63	MP0002752_abnormal_somatic_nervous	1.11597017
64	MP0001970_abnormal_pain_threshold	1.10955890
65	MP0009046_muscle_twitch	1.07601796
66	MP0003942_abnormal_urinary_system	1.06139945
67	MP0002876_abnormal_thyroid_physiology	1.04168048
68	MP0002572_abnormal_emotion/affect_behav	1.02509269
69	MP0003635_abnormal_synaptic_transmissio	1.02459652
70	MP0010030_abnormal_orbit_morphology	1.02295057
71	MP0001486_abnormal_startle_reflex	1.01022332
72	MP0009053_abnormal_anal_canal	1.00739155
73	MP0002233_abnormal_nose_morphology	1.00727997
74	MP0002736_abnormal_nociception_after	0.97717781
75	MP0001963_abnormal_hearing_physiology	0.97051858
76	MP0001986_abnormal_taste_sensitivity	0.96699528
77	MP0001286_abnormal_eye_development	0.96561655
78	MP0002882_abnormal_neuron_morphology	0.95962621
79	MP0001440_abnormal_grooming_behavior	0.95429565
80	MP0002063_abnormal_learning/memory/cond	0.94981445
81	MP0003119_abnormal_digestive_system	0.93495248
82	MP0002210_abnormal_sex_determination	0.90971654
83	MP0003186_abnormal_redox_activity	0.90576972
84	MP0002735_abnormal_chemical_nociception	0.89379382
85	MP0002734_abnormal_mechanical_nocicepti	0.88950476
86	MP0002095_abnormal_skin_pigmentation	0.88021416
87	MP0004859_abnormal_synaptic_plasticity	0.87046888
88	MP0004145_abnormal_muscle_electrophysio	0.84663394
89	MP0002152_abnormal_brain_morphology	0.84299284
90	MP0008872_abnormal_physiological_respon	0.83933446
91	MP0002277_abnormal_respiratory_mucosa	0.82675327
92	MP0003861_abnormal_nervous_system	0.81629050
93	MP0008058_abnormal_DNA_repair	0.79872003
94	MP0003315_abnormal_perineum_morphology	0.79704712
95	MP0003890_abnormal_embryonic-extraembry	0.79380233
96	MP0002067_abnormal_sensory_capabilities	0.78208997
97	MP0002064_seizures	0.76312478
98	MP0009250_abnormal_appendicular_skeleto	0.73780772
99	MP0003755_abnormal_palate_morphology	0.73477841
100	MP0000230_abnormal_systemic_arterial	0.71443892

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.38157681
2	Acute necrotizing encephalopathy (HP:0006965)	4.34313978
3	Absent/shortened dynein arms (HP:0200106)	4.00797547
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.00797547
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.96496446
6	Molar tooth sign on MRI (HP:0002419)	3.74899357
7	Abnormality of midbrain morphology (HP:0002418)	3.74899357
8	Acute encephalopathy (HP:0006846)	3.70384545
9	Mitochondrial inheritance (HP:0001427)	3.62966179
10	Progressive macrocephaly (HP:0004481)	3.57627479
11	Abnormality of cells of the erythroid lineage (HP:0012130)	3.53083458
12	Medial flaring of the eyebrow (HP:0010747)	3.43509162
13	Septo-optic dysplasia (HP:0100842)	3.36755695
14	True hermaphroditism (HP:0010459)	3.33376243
15	Myokymia (HP:0002411)	3.32493506
16	Pancreatic fibrosis (HP:0100732)	3.32141840
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.29778932
18	Nephronophthisis (HP:0000090)	3.20175419
19	Macrocytic anemia (HP:0001972)	3.14259853
20	Increased CSF lactate (HP:0002490)	3.13530166
21	Abnormal number of erythroid precursors (HP:0012131)	3.06157902
22	Gait imbalance (HP:0002141)	3.05420288
23	Pancreatic cysts (HP:0001737)	3.04395729
24	Renal Fanconi syndrome (HP:0001994)	3.00820118
25	Lipid accumulation in hepatocytes (HP:0006561)	2.99560958
26	Increased hepatocellular lipid droplets (HP:0006565)	2.96844138
27	Colon cancer (HP:0003003)	2.92621268
28	Abnormal rod and cone electroretinograms (HP:0008323)	2.90442567
29	Nephrogenic diabetes insipidus (HP:0009806)	2.87704604
30	Congenital primary aphakia (HP:0007707)	2.84492882
31	Hepatocellular necrosis (HP:0001404)	2.83298715
32	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.82742868
33	Abnormal ciliary motility (HP:0012262)	2.77463317
34	Abnormal respiratory epithelium morphology (HP:0012253)	2.74956084
35	Abnormal respiratory motile cilium morphology (HP:0005938)	2.74956084
36	Sclerocornea (HP:0000647)	2.72021725
37	3-Methylglutaconic aciduria (HP:0003535)	2.70034017
38	Adrenal hypoplasia (HP:0000835)	2.65001291
39	Cerebral edema (HP:0002181)	2.62697862
40	Abnormality of the renal medulla (HP:0100957)	2.58506633
41	Hepatic necrosis (HP:0002605)	2.54292519
42	Hyperglycinemia (HP:0002154)	2.42724174
43	Increased intramyocellular lipid droplets (HP:0012240)	2.40229083
44	Absent thumb (HP:0009777)	2.40070596
45	Abnormality of renal resorption (HP:0011038)	2.39156665
46	Abnormal respiratory motile cilium physiology (HP:0012261)	2.37305575
47	Polyphagia (HP:0002591)	2.36586093
48	Optic nerve hypoplasia (HP:0000609)	2.35848511
49	Anencephaly (HP:0002323)	2.35461071
50	Pallor (HP:0000980)	2.34791654
51	Optic disc pallor (HP:0000543)	2.29601073
52	Vaginal atresia (HP:0000148)	2.24166296
53	Rib fusion (HP:0000902)	2.24144607
54	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.22945907
55	Genital tract atresia (HP:0001827)	2.22126703
56	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.20837360
57	Lissencephaly (HP:0001339)	2.20629385
58	Anophthalmia (HP:0000528)	2.19104833
59	Oligodactyly (hands) (HP:0001180)	2.19040373
60	Congenital stationary night blindness (HP:0007642)	2.13010272
61	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.11281925
62	Type II lissencephaly (HP:0007260)	2.10928097
63	Diastasis recti (HP:0001540)	2.10559910
64	Supernumerary spleens (HP:0009799)	2.09298466
65	Increased muscle lipid content (HP:0009058)	2.09283197
66	Poor coordination (HP:0002370)	2.07353092
67	Absent septum pellucidum (HP:0001331)	2.04397687
68	Maternal diabetes (HP:0009800)	2.03188756
69	Growth hormone deficiency (HP:0000824)	2.02666111
70	Asplenia (HP:0001746)	2.02501593
71	Cystic liver disease (HP:0006706)	2.01679147
72	Male pseudohermaphroditism (HP:0000037)	1.96912568
73	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.94207941
74	Lactic acidosis (HP:0003128)	1.93978319
75	Postaxial foot polydactyly (HP:0001830)	1.93264470
76	Oligodactyly (HP:0012165)	1.92860097
77	Chronic hepatic failure (HP:0100626)	1.90767554
78	Abolished electroretinogram (ERG) (HP:0000550)	1.89981286
79	Pachygyria (HP:0001302)	1.89889945
80	Hepatoblastoma (HP:0002884)	1.87340728
81	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.86404850
82	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.86404850
83	Exertional dyspnea (HP:0002875)	1.85578785
84	Abnormality of the labia minora (HP:0012880)	1.84355314
85	Decreased central vision (HP:0007663)	1.83291981
86	Depressed nasal ridge (HP:0000457)	1.82183846
87	Methylmalonic acidemia (HP:0002912)	1.81867581
88	Postaxial hand polydactyly (HP:0001162)	1.79833716
89	Methylmalonic aciduria (HP:0012120)	1.79594455
90	Glycosuria (HP:0003076)	1.79239861
91	Abnormality of urine glucose concentration (HP:0011016)	1.79239861
92	Abnormal pancreas size (HP:0012094)	1.78583092
93	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.77951233
94	Leukodystrophy (HP:0002415)	1.75724344
95	Agitation (HP:0000713)	1.74490899
96	Aganglionic megacolon (HP:0002251)	1.74415906
97	Stenosis of the external auditory canal (HP:0000402)	1.74128968
98	Hypoplastic pelvis (HP:0008839)	1.73836953
99	Tubular atrophy (HP:0000092)	1.73797876
100	Specific learning disability (HP:0001328)	1.72809944

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	4.07613817
2	TNIK	2.91984352
3	CASK	2.89948145
4	DYRK2	2.61135832
5	VRK2	2.49777205
6	TLK1	2.36729168
7	NUAK1	2.19594889
8	BCKDK	2.12187664
9	PINK1	1.99307633
10	CDK19	1.89890041
11	MARK1	1.86442142
12	CDC7	1.85904361
13	EPHB2	1.74438493
14	NTRK2	1.72954361
15	PIM2	1.69690428
16	WNK3	1.64209667
17	NME2	1.62337970
18	BMPR1B	1.59590647
19	GRK1	1.56427127
20	MAP2K7	1.50135228
21	MAP3K4	1.50071189
22	ADRBK2	1.48378409
23	WNK4	1.46872256
24	MAP3K11	1.46775349
25	TAF1	1.43947572
26	PIK3CA	1.43360043
27	VRK1	1.38714209
28	MAP4K2	1.35412123
29	FRK	1.34096535
30	ZAK	1.31813628
31	MINK1	1.31193268
32	ARAF	1.24920352
33	EPHA4	1.24242154
34	PRKCG	1.18426913
35	BCR	1.15103023
36	CSNK1G2	1.13156106
37	MAPK13	1.13038083
38	CAMK1	1.08899979
39	OXSR1	1.02421499
40	NTRK3	1.01368789
41	CSNK1G3	1.01204682
42	AURKA	1.00015864
43	CAMK1D	0.98688253
44	ABL2	0.97830314
45	STK11	0.94924872
46	MAP3K9	0.93565639
47	TAOK3	0.93143848
48	BRAF	0.90984782
49	DYRK1B	0.84226298
50	LIMK1	0.84190131
51	CAMK1G	0.82166870
52	NEK1	0.81774578
53	DYRK3	0.80748974
54	TYRO3	0.79034561
55	ADRBK1	0.76573918
56	CSNK1G1	0.74873104
57	DAPK3	0.74640581
58	STK39	0.72711637
59	PLK1	0.72654909
60	MAP2K4	0.71871375
61	CSNK1A1L	0.70684694
62	NME1	0.69401410
63	INSRR	0.69206432
64	PHKG1	0.69184677
65	PHKG2	0.69184677
66	PLK4	0.67825676
67	DYRK1A	0.65376918
68	MAPKAPK5	0.65248547
69	PNCK	0.63496932
70	WEE1	0.61968805
71	PAK3	0.61632479
72	CAMKK2	0.60229848
73	PRKCZ	0.59869582
74	TRIM28	0.58704540
75	PRKACA	0.58589794
76	CSNK2A2	0.56041629
77	CSNK1E	0.55344732
78	SGK223	0.54821026
79	SGK494	0.54821026
80	PRKCQ	0.54433556
81	BRSK2	0.52067425
82	PRKCI	0.51995648
83	GRK7	0.51920585
84	GRK5	0.51850177
85	MAP3K12	0.50957556
86	PLK3	0.50474713
87	TXK	0.49045540
88	CDK8	0.48891186
89	PRKCE	0.48611281
90	NEK2	0.48511681
91	TIE1	0.47838435
92	SIK2	0.47412630
93	RPS6KA5	0.46711580
94	CSNK1A1	0.45787820
95	BRSK1	0.45442571
96	MUSK	0.43441984
97	CDK5	0.43183836
98	RPS6KA2	0.42534288
99	STK24	0.42154230
100	PLK2	0.42124793

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.85160524
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.75946931
3	Parkinsons disease_Homo sapiens_hsa05012	4.11530336
4	Huntingtons disease_Homo sapiens_hsa05016	2.91478753
5	Cardiac muscle contraction_Homo sapiens_hsa04260	2.82934001
6	Alzheimers disease_Homo sapiens_hsa05010	2.76827496
7	Protein export_Homo sapiens_hsa03060	2.57227909
8	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.52323386
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.31502575
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.94798237
11	Nicotine addiction_Homo sapiens_hsa05033	1.83561290
12	RNA polymerase_Homo sapiens_hsa03020	1.78524611
13	Mismatch repair_Homo sapiens_hsa03430	1.77391077
14	Homologous recombination_Homo sapiens_hsa03440	1.76485709
15	Proteasome_Homo sapiens_hsa03050	1.75582753
16	Phototransduction_Homo sapiens_hsa04744	1.72734427
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.70708764
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.42457575
19	Sulfur relay system_Homo sapiens_hsa04122	1.42155890
20	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.35195580
21	Basal transcription factors_Homo sapiens_hsa03022	1.32451193
22	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.31662383
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.28093478
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.28078667
25	Collecting duct acid secretion_Homo sapiens_hsa04966	1.27050809
26	Basal cell carcinoma_Homo sapiens_hsa05217	1.22084954
27	Peroxisome_Homo sapiens_hsa04146	1.22056326
28	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.17505939
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.14220644
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.09137894
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.09067991
32	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.07063857
33	RNA degradation_Homo sapiens_hsa03018	1.06506966
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.05496317
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.04335790
36	Propanoate metabolism_Homo sapiens_hsa00640	1.02389126
37	Butanoate metabolism_Homo sapiens_hsa00650	1.01844163
38	Pyrimidine metabolism_Homo sapiens_hsa00240	0.97717428
39	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.93615387
40	One carbon pool by folate_Homo sapiens_hsa00670	0.92692105
41	Fatty acid elongation_Homo sapiens_hsa00062	0.91966673
42	Morphine addiction_Homo sapiens_hsa05032	0.91940948
43	GABAergic synapse_Homo sapiens_hsa04727	0.89667513
44	Regulation of autophagy_Homo sapiens_hsa04140	0.89064602
45	Steroid biosynthesis_Homo sapiens_hsa00100	0.87922021
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.87005433
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.81169286
48	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.77603265
49	Metabolic pathways_Homo sapiens_hsa01100	0.75461468
50	Purine metabolism_Homo sapiens_hsa00230	0.74109567
51	Axon guidance_Homo sapiens_hsa04360	0.72564048
52	Base excision repair_Homo sapiens_hsa03410	0.70078659
53	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.69716278
54	Ether lipid metabolism_Homo sapiens_hsa00565	0.69384091
55	Serotonergic synapse_Homo sapiens_hsa04726	0.67899329
56	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.66013421
57	Olfactory transduction_Homo sapiens_hsa04740	0.65978971
58	Glutamatergic synapse_Homo sapiens_hsa04724	0.64280907
59	DNA replication_Homo sapiens_hsa03030	0.62334066
60	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.60090319
61	Dopaminergic synapse_Homo sapiens_hsa04728	0.58476114
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.58423341
63	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.57829840
64	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.57582446
65	Cocaine addiction_Homo sapiens_hsa05030	0.56861341
66	Pyruvate metabolism_Homo sapiens_hsa00620	0.54582225
67	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.54252905
68	Folate biosynthesis_Homo sapiens_hsa00790	0.52898622
69	Retinol metabolism_Homo sapiens_hsa00830	0.52654078
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.52625904
71	Caffeine metabolism_Homo sapiens_hsa00232	0.52592651
72	Insulin secretion_Homo sapiens_hsa04911	0.51808149
73	RNA transport_Homo sapiens_hsa03013	0.51775672
74	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.51344629
75	Fatty acid degradation_Homo sapiens_hsa00071	0.50364150
76	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.50186740
77	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.49368319
78	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.48930024
79	p53 signaling pathway_Homo sapiens_hsa04115	0.46745594
80	Spliceosome_Homo sapiens_hsa03040	0.45875683
81	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.44521668
82	Notch signaling pathway_Homo sapiens_hsa04330	0.43851983
83	Selenocompound metabolism_Homo sapiens_hsa00450	0.43070483
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.42588243
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.41368433
86	Asthma_Homo sapiens_hsa05310	0.41298730
87	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.40864869
88	Circadian entrainment_Homo sapiens_hsa04713	0.40830530
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.40314590
90	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.40116110
91	Nitrogen metabolism_Homo sapiens_hsa00910	0.37688376
92	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.36072979
93	Taste transduction_Homo sapiens_hsa04742	0.35613834
94	Glutathione metabolism_Homo sapiens_hsa00480	0.35360480
95	Hippo signaling pathway_Homo sapiens_hsa04390	0.34610905
96	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.33574324
97	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.30893545
98	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.29555715
99	Cholinergic synapse_Homo sapiens_hsa04725	0.29425733
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.28716576

ARMCX7P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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