ARMS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is thought to play a role in diseases in the elderly. Mutations in this gene have been associated with age-related macular degeneration. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.32733786
2plasma membrane fusion (GO:0045026)8.60819795
3multicellular organism reproduction (GO:0032504)7.52656391
4microtubule depolymerization (GO:0007019)7.07099784
5sperm capacitation (GO:0048240)6.50038145
6reproduction (GO:0000003)6.28610950
7sperm-egg recognition (GO:0035036)6.23323314
8calcium ion-dependent exocytosis (GO:0017156)6.07191906
9spermatid development (GO:0007286)6.06936453
10chromosome condensation (GO:0030261)5.93287486
11spermatid nucleus differentiation (GO:0007289)5.83068753
12DNA packaging (GO:0006323)5.78643840
13response to pheromone (GO:0019236)5.78287024
14protein polyglutamylation (GO:0018095)5.74289253
15binding of sperm to zona pellucida (GO:0007339)5.71520595
16protein targeting to Golgi (GO:0000042)5.69415335
17single strand break repair (GO:0000012)5.55207618
18establishment of protein localization to Golgi (GO:0072600)5.53265293
19microtubule polymerization or depolymerization (GO:0031109)5.52758211
20RNA destabilization (GO:0050779)5.33037949
21regulation of cilium movement (GO:0003352)5.31171024
22centriole replication (GO:0007099)5.27557867
23retrograde transport, vesicle recycling within Golgi (GO:0000301)5.19537927
24cellular ketone body metabolic process (GO:0046950)5.11946731
25cell-cell recognition (GO:0009988)5.03422654
26phosphatidylethanolamine biosynthetic process (GO:0006646)4.99062243
27RNA localization (GO:0006403)4.98302247
28spermatogenesis (GO:0007283)4.79292846
29rRNA methylation (GO:0031167)4.79282962
30male gamete generation (GO:0048232)4.77306086
31gamete generation (GO:0007276)4.58396155
32phosphatidylethanolamine metabolic process (GO:0046337)4.50510312
33ketone body metabolic process (GO:1902224)4.48817163
34negative regulation of inclusion body assembly (GO:0090084)4.29754995
35centriole assembly (GO:0098534)4.28322112
36single fertilization (GO:0007338)4.21063896
37axonemal dynein complex assembly (GO:0070286)4.07620573
38coenzyme catabolic process (GO:0009109)4.06587036
39protein localization to Golgi apparatus (GO:0034067)4.00278741
40rRNA modification (GO:0000154)3.93770471
41sexual reproduction (GO:0019953)3.86283402
42cilium or flagellum-dependent cell motility (GO:0001539)3.82111311
43germ cell development (GO:0007281)3.76757336
44multicellular organismal reproductive process (GO:0048609)3.76081124
45seminiferous tubule development (GO:0072520)3.73884329
46estrogen biosynthetic process (GO:0006703)3.69674380
47glomerular visceral epithelial cell development (GO:0072015)3.63306281
48cellular process involved in reproduction in multicellular organism (GO:0022412)3.57475655
49microtubule severing (GO:0051013)3.55029095
50regulation of microtubule-based movement (GO:0060632)3.54296118
51artery development (GO:0060840)3.45448282
52regulation of Rab GTPase activity (GO:0032313)3.40965781
53positive regulation of Rab GTPase activity (GO:0032851)3.40965781
54negative regulation of astrocyte differentiation (GO:0048712)3.37829407
55fertilization (GO:0009566)3.36694248
56glomerular epithelial cell development (GO:0072310)3.35765813
57regulation of transcription involved in cell fate commitment (GO:0060850)3.33565087
58positive regulation of dendritic spine morphogenesis (GO:0061003)3.32459188
59regulation of inclusion body assembly (GO:0090083)3.32411184
60motile cilium assembly (GO:0044458)3.26134663
61glycerol ether metabolic process (GO:0006662)3.23994559
62cell wall macromolecule catabolic process (GO:0016998)3.16949586
63cell recognition (GO:0008037)3.15231459
64cerebral cortex radially oriented cell migration (GO:0021799)3.12115333
65epithelial cilium movement (GO:0003351)3.11637225
66ether metabolic process (GO:0018904)3.02820920
67fat-soluble vitamin biosynthetic process (GO:0042362)2.99873483
68nucleus organization (GO:0006997)2.98035917
69musculoskeletal movement (GO:0050881)2.96599789
70multicellular organismal movement (GO:0050879)2.96599789
71cofactor catabolic process (GO:0051187)2.92952423
72cell wall macromolecule metabolic process (GO:0044036)2.87525624
73NLS-bearing protein import into nucleus (GO:0006607)2.86756907
74neurotransmitter-gated ion channel clustering (GO:0072578)2.85351202
75cranial nerve morphogenesis (GO:0021602)2.85263390
76microtubule nucleation (GO:0007020)2.85239311
77mitochondrial fission (GO:0000266)2.83730141
78phagocytosis, recognition (GO:0006910)2.78531681
79oogenesis (GO:0048477)2.78315176
80peptidyl-glutamic acid modification (GO:0018200)2.78123691
81regulation of phosphoprotein phosphatase activity (GO:0043666)2.73980808
82axoneme assembly (GO:0035082)2.71933051
83short-term memory (GO:0007614)2.71883116
84cilium movement (GO:0003341)2.70510929
85secretory granule organization (GO:0033363)2.68162124
86negative regulation of neurotransmitter secretion (GO:0046929)2.67895545
87spliceosomal tri-snRNP complex assembly (GO:0000244)2.67186099
88positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.66667345
89negative regulation of oligodendrocyte differentiation (GO:0048715)2.66428387
90centrosome duplication (GO:0051298)2.63287005
91forebrain morphogenesis (GO:0048853)2.62252377
92regulation of centriole replication (GO:0046599)2.58857206
93positive regulation of adenylate cyclase activity (GO:0045762)2.58533369
94sympathetic nervous system development (GO:0048485)2.58417832
95epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.58101035
96peptidyl-threonine dephosphorylation (GO:0035970)2.56991254
97estrogen metabolic process (GO:0008210)2.56636671
98lateral ventricle development (GO:0021670)2.48090796
99acrosome reaction (GO:0007340)11.6676324
100fusion of sperm to egg plasma membrane (GO:0007342)11.1177873

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.18012858
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.33750221
3CTBP2_25329375_ChIP-Seq_LNCAP_Human2.42330583
4CTBP1_25329375_ChIP-Seq_LNCAP_Human2.40088599
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.35348985
6VDR_22108803_ChIP-Seq_LS180_Human2.22767711
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.18268219
8POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.14696476
9TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14696476
10FUS_26573619_Chip-Seq_HEK293_Human2.12532720
11CBP_20019798_ChIP-Seq_JUKART_Human2.02490239
12IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.02490239
13TAF15_26573619_Chip-Seq_HEK293_Human1.88126105
14SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.86786331
15UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.84799766
16P300_19829295_ChIP-Seq_ESCs_Human1.82610631
17TP53_18474530_ChIP-ChIP_U2OS_Human1.81036339
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.76585234
19SMAD4_21741376_ChIP-Seq_EPCs_Human1.76345876
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69924446
21SMAD3_21741376_ChIP-Seq_EPCs_Human1.69741483
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66232498
23AR_25329375_ChIP-Seq_VCAP_Human1.65661938
24GBX2_23144817_ChIP-Seq_PC3_Human1.60574179
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59458712
26ER_23166858_ChIP-Seq_MCF-7_Human1.58273813
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58117210
28DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.56630520
29TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55941678
30SMAD4_21799915_ChIP-Seq_A2780_Human1.55801626
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.54606438
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54154276
33SMAD3_21741376_ChIP-Seq_ESCs_Human1.46434501
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.44494270
35* ERA_21632823_ChIP-Seq_H3396_Human1.43618189
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.42237397
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41029500
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40080724
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40006121
40RUNX2_22187159_ChIP-Seq_PCA_Human1.39709550
41CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37293883
42TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37192318
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36447193
44DROSHA_22980978_ChIP-Seq_HELA_Human1.35685969
45MYC_19829295_ChIP-Seq_ESCs_Human1.34114007
46STAT3_23295773_ChIP-Seq_U87_Human1.30698711
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.30434679
48ZNF274_21170338_ChIP-Seq_K562_Hela1.25646894
49SOX2_19829295_ChIP-Seq_ESCs_Human1.25039958
50NANOG_19829295_ChIP-Seq_ESCs_Human1.25039958
51KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23987824
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.23314715
53TBL1_22424771_ChIP-Seq_293T_Human1.23304063
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23001358
55WDR5_24793694_ChIP-Seq_LNCAP_Human1.22510101
56CBX2_22325352_ChIP-Seq_293T-Rex_Human1.22328265
57FOXH1_21741376_ChIP-Seq_EPCs_Human1.22317251
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22268224
59TCF4_23295773_ChIP-Seq_U87_Human1.22161192
60EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22018692
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21722445
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21364320
63CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.21082381
64TCF4_18268006_ChIP-ChIP_LS174T_Human1.21021887
65LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20793301
66ETV1_20927104_ChIP-Seq_GIST48_Human1.20063055
67NFYB_21822215_ChIP-Seq_K562_Human1.19944133
68AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19285417
69CJUN_26792858_Chip-Seq_BT549_Human1.18807694
70HNFA_21074721_ChIP-Seq_CACO-2_Human1.18617378
71NANOG_20526341_ChIP-Seq_ESCs_Human1.17749784
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.16870010
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16678059
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.16454489
75CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.15526802
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14777978
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14737370
78RAC3_21632823_ChIP-Seq_H3396_Human1.14345332
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12407219
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11916093
81EZH2_27294783_Chip-Seq_ESCs_Mouse1.11204741
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10994160
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.10863614
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10149938
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10090915
86TDRD3_21172665_ChIP-Seq_MCF-7_Human1.08646209
87RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.08597151
88P53_21459846_ChIP-Seq_SAOS-2_Human1.08557976
89SMAD4_21741376_ChIP-Seq_HESCs_Human1.07201747
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06578531
91RBPJ_21746931_ChIP-Seq_IB4_Human1.06372867
92KLF4_19829295_ChIP-Seq_ESCs_Human1.05981359
93AR_21572438_ChIP-Seq_LNCaP_Human1.05973639
94TAF2_19829295_ChIP-Seq_ESCs_Human1.05895759
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.05779486
96PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05767918
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05481087
98ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05451991
99IRF1_19129219_ChIP-ChIP_H3396_Human1.04217306
100VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04096799

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.79930557
2MP0006054_spinal_hemorrhage4.01919102
3MP0005670_abnormal_white_adipose3.71790762
4MP0003698_abnormal_male_reproductive3.45543537
5MP0001929_abnormal_gametogenesis2.98908383
6MP0003011_delayed_dark_adaptation2.87020621
7MP0005377_hearing/vestibular/ear_phenot2.64386850
8MP0003878_abnormal_ear_physiology2.64386850
9MP0001879_abnormal_lymphatic_vessel2.33889335
10MP0004510_myositis2.30084779
11MP0009697_abnormal_copulation2.23684440
12MP0003880_abnormal_central_pattern2.08310078
13MP0002234_abnormal_pharynx_morphology1.93457274
14MP0005645_abnormal_hypothalamus_physiol1.92672714
15MP0002653_abnormal_ependyma_morphology1.86983882
16MP0002161_abnormal_fertility/fecundity1.85270659
17MP0005423_abnormal_somatic_nervous1.84461940
18MP0005666_abnormal_adipose_tissue1.81026370
19MP0001968_abnormal_touch/_nociception1.80883314
20MP0005379_endocrine/exocrine_gland_phen1.73932235
21MP0003045_fibrosis1.72207304
22MP0002735_abnormal_chemical_nociception1.62551962
23MP0004742_abnormal_vestibular_system1.60072154
24MP0005646_abnormal_pituitary_gland1.58980933
25MP0003718_maternal_effect1.56890310
26MP0002210_abnormal_sex_determination1.53455303
27MP0001486_abnormal_startle_reflex1.51308983
28MP0003941_abnormal_skin_development1.45898846
29MP0002736_abnormal_nociception_after1.45764379
30MP0002249_abnormal_larynx_morphology1.45727375
31MP0005551_abnormal_eye_electrophysiolog1.39375124
32MP0001348_abnormal_lacrimal_gland1.38473834
33MP0010307_abnormal_tumor_latency1.34794507
34MP0000534_abnormal_ureter_morphology1.30501912
35MP0008877_abnormal_DNA_methylation1.30499064
36MP0005395_other_phenotype1.28853349
37MP0008872_abnormal_physiological_respon1.26967418
38MP0004134_abnormal_chest_morphology1.25966088
39MP0005375_adipose_tissue_phenotype1.24408281
40MP0001984_abnormal_olfaction1.24221318
41MP0004270_analgesia1.21545515
42MP0002168_other_aberrant_phenotype1.18972676
43MP0006276_abnormal_autonomic_nervous1.18634456
44MP0008789_abnormal_olfactory_epithelium1.18390985
45MP0002163_abnormal_gland_morphology1.14527443
46MP0000230_abnormal_systemic_arterial1.09888552
47MP0001145_abnormal_male_reproductive1.09104674
48MP0002108_abnormal_muscle_morphology1.08756901
49MP0003943_abnormal_hepatobiliary_system1.06884592
50MP0002733_abnormal_thermal_nociception1.05870557
51MP0000653_abnormal_sex_gland1.04506856
52MP0004085_abnormal_heartbeat1.03605482
53MP0001440_abnormal_grooming_behavior1.02601370
54MP0002734_abnormal_mechanical_nocicepti1.02498286
55MP0002067_abnormal_sensory_capabilities0.96947770
56MP0009115_abnormal_fat_cell0.96689987
57MP0000249_abnormal_blood_vessel0.93966860
58MP0002557_abnormal_social/conspecific_i0.92113514
59MP0004484_altered_response_of0.91519764
60MP0000613_abnormal_salivary_gland0.90605162
61MP0005310_abnormal_salivary_gland0.90175472
62MP0002132_abnormal_respiratory_system0.89875321
63MP0005394_taste/olfaction_phenotype0.89571879
64MP0005499_abnormal_olfactory_system0.89571879
65MP0003633_abnormal_nervous_system0.88822690
66MP0009745_abnormal_behavioral_response0.86909792
67MP0002233_abnormal_nose_morphology0.86617761
68MP0001529_abnormal_vocalization0.85450300
69MP0002272_abnormal_nervous_system0.85213820
70MP0002229_neurodegeneration0.83145527
71MP0004084_abnormal_cardiac_muscle0.82970738
72MP0005386_behavior/neurological_phenoty0.80996684
73MP0004924_abnormal_behavior0.80996684
74MP0001963_abnormal_hearing_physiology0.77438572
75MP0003942_abnormal_urinary_system0.77417599
76MP0005408_hypopigmentation0.77055756
77MP0001485_abnormal_pinna_reflex0.74165358
78MP0009053_abnormal_anal_canal0.74153408
79MP0000733_abnormal_muscle_development0.72083584
80MP0005647_abnormal_sex_gland0.71920341
81MP0003935_abnormal_craniofacial_develop0.71325802
82MP0000678_abnormal_parathyroid_gland0.70193866
83MP0001970_abnormal_pain_threshold0.69149772
84MP0000639_abnormal_adrenal_gland0.68438494
85MP0003385_abnormal_body_wall0.66337801
86MP0003631_nervous_system_phenotype0.66235503
87MP0000955_abnormal_spinal_cord0.66154602
88MP0005253_abnormal_eye_physiology0.66085163
89MP0004883_abnormal_blood_vessel0.65788070
90MP0001765_abnormal_ion_homeostasis0.65720803
91MP0005164_abnormal_response_to0.65483164
92MP0002127_abnormal_cardiovascular_syste0.65346934
93MP0002572_abnormal_emotion/affect_behav0.64860880
94MP0000026_abnormal_inner_ear0.64590914
95MP0004859_abnormal_synaptic_plasticity0.62852237
96MP0002064_seizures0.62711791
97MP0010368_abnormal_lymphatic_system0.60193845
98MP0001958_emphysema0.59292154
99MP0002822_catalepsy0.58313371
100MP0003635_abnormal_synaptic_transmissio0.57640822

Predicted human phenotypes

RankGene SetZ-score
1Cone-rod dystrophy (HP:0000548)5.03489820
2Joint hemorrhage (HP:0005261)4.58619897
3Severe visual impairment (HP:0001141)4.54809773
4Abnormality of the intrinsic pathway (HP:0010989)4.53180994
5Abnormality of the parathyroid morphology (HP:0011766)4.46733194
6Prolonged partial thromboplastin time (HP:0003645)4.37606862
7Absent/shortened dynein arms (HP:0200106)4.29123489
8Dynein arm defect of respiratory motile cilia (HP:0012255)4.29123489
9Abnormality of macular pigmentation (HP:0008002)4.00479918
10Midline defect of the nose (HP:0004122)3.95294306
11Meningioma (HP:0002858)3.92861531
12Attenuation of retinal blood vessels (HP:0007843)3.92616361
13Bony spicule pigmentary retinopathy (HP:0007737)3.90502502
14Abnormal ciliary motility (HP:0012262)3.54778012
15Chronic hepatic failure (HP:0100626)3.49023038
16Abnormal respiratory motile cilium physiology (HP:0012261)3.43800343
17Aqueductal stenosis (HP:0002410)3.34066724
18Ulnar claw (HP:0001178)3.31573379
19Abnormality of the astrocytes (HP:0100707)3.29377755
20Astrocytoma (HP:0009592)3.29377755
21Abnormal respiratory epithelium morphology (HP:0012253)3.25133023
22Abnormal respiratory motile cilium morphology (HP:0005938)3.25133023
23Male infertility (HP:0003251)3.21142605
24Rhabdomyosarcoma (HP:0002859)3.12638263
25Resting tremor (HP:0002322)3.09355514
26Abnormality of the nasal septum (HP:0000419)3.06625974
27Action tremor (HP:0002345)3.04457671
28Decreased central vision (HP:0007663)3.02965404
29Tubulointerstitial nephritis (HP:0001970)3.02038549
30Portal hypertension (HP:0001409)3.01216761
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.98973648
32Potter facies (HP:0002009)2.92956109
33Facial shape deformation (HP:0011334)2.92956109
34Asymmetric septal hypertrophy (HP:0001670)2.88834995
35Glioma (HP:0009733)2.88718003
36Rhinitis (HP:0012384)2.80602420
37Neoplasm of striated muscle (HP:0009728)2.72112804
38Abnormality of the hepatic vasculature (HP:0006707)2.71700265
39Infertility (HP:0000789)2.52149871
40Enlarged epiphyses (HP:0010580)2.42141867
41Bulbous nose (HP:0000414)2.42137983
42Hyperkalemia (HP:0002153)2.39991710
43Oligodontia (HP:0000677)2.38292356
44Pendular nystagmus (HP:0012043)2.34593201
45Neoplasm of the peripheral nervous system (HP:0100007)2.33795523
46Abnormal rod and cone electroretinograms (HP:0008323)2.31931742
47Esophageal varix (HP:0002040)2.31370334
48Aplasia/Hypoplasia of the earlobes (HP:0009906)2.30645811
49Neuroendocrine neoplasm (HP:0100634)2.30205110
50Benign neoplasm of the central nervous system (HP:0100835)2.28888103
51Hypoplastic ischia (HP:0003175)2.23139284
52Scotoma (HP:0000575)2.20504388
53Pheochromocytoma (HP:0002666)2.18990627
54Abnormality of the nasal mucosa (HP:0000433)2.17751043
55Overgrowth (HP:0001548)2.13733767
56Progressive cerebellar ataxia (HP:0002073)2.13295845
57Abnormal spermatogenesis (HP:0008669)2.12810023
58Hyperglycinuria (HP:0003108)2.10162183
59Abnormality of the ischium (HP:0003174)2.09949046
60Conical tooth (HP:0000698)2.08121826
61Nuclear cataract (HP:0100018)2.08036395
62Nephronophthisis (HP:0000090)2.07548176
63Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.07372333
64Azoospermia (HP:0000027)2.05993914
65Nasal polyposis (HP:0100582)2.03313113
66Generalized aminoaciduria (HP:0002909)1.94715434
67Progressive sensorineural hearing impairment (HP:0000408)1.94011049
68Abnormality of the renal medulla (HP:0100957)1.93502184
69Insidious onset (HP:0003587)1.93210149
70Termporal pattern (HP:0011008)1.93210149
71Volvulus (HP:0002580)1.91086565
72Postural instability (HP:0002172)1.90849993
73Abnormal albumin level (HP:0012116)1.90813375
74Hypoalbuminemia (HP:0003073)1.90813375
75Abnormal urine output (HP:0012590)1.89208687
76Atonic seizures (HP:0010819)1.89114212
77Congenital malformation of the right heart (HP:0011723)1.87255957
78Double outlet right ventricle (HP:0001719)1.87255957
79Abnormality of chromosome segregation (HP:0002916)1.86952983
80Congenital stationary night blindness (HP:0007642)1.86154746
81Medial flaring of the eyebrow (HP:0010747)1.85520198
82Polydipsia (HP:0001959)1.84630653
83Abnormal drinking behavior (HP:0030082)1.84630653
84Impulsivity (HP:0100710)1.83929084
85Genital tract atresia (HP:0001827)1.83924449
86Paraparesis (HP:0002385)1.82074920
87Osteomalacia (HP:0002749)1.80618247
88Retinal dysplasia (HP:0007973)1.79969630
89Intellectual disability, moderate (HP:0002342)1.78766539
90Hypoplasia of the thymus (HP:0000778)1.78281638
91Chronic sinusitis (HP:0011109)1.77674115
92Fibrous tissue neoplasm (HP:0012316)1.77430910
93Neoplasm of the oral cavity (HP:0100649)1.76908549
94Stage 5 chronic kidney disease (HP:0003774)1.75686446
95Congenital sensorineural hearing impairment (HP:0008527)1.75225138
96Increased purine levels (HP:0004368)1.75223964
97Hyperuricemia (HP:0002149)1.75223964
98Pancreatic cysts (HP:0001737)1.74231787
99Curly hair (HP:0002212)1.73208709
100Sensory axonal neuropathy (HP:0003390)1.72799108

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK36.11545329
2PLK45.26884863
3PNCK4.32145461
4STK383.16998364
5TESK12.95006417
6INSRR2.64917568
7STK38L2.54431292
8PINK12.42910647
9FRK2.39266744
10CAMK1G2.31777494
11DDR22.31397391
12PRKD32.26798517
13TNIK2.19061682
14BRD42.10222410
15MARK12.04253991
16NUAK12.00680763
17PDGFRA1.97083678
18NTRK31.96792414
19PLK21.93877541
20MAP4K21.83316711
21PIK3CG1.82266276
22TIE11.68693174
23MAPK131.52769941
24MAP3K131.42592293
25SIK21.38335264
26MAP3K41.29670229
27PTK2B1.25459895
28CAMK11.23575646
29MYLK1.22685596
30CASK1.17785013
31PKN11.15811892
32MAP2K71.14792470
33KSR21.13953015
34MAP3K61.11381186
35ROCK11.02356245
36MAPK151.00229471
37MKNK20.90658745
38PRKAA20.89714201
39MAP3K120.88661029
40BRSK20.87038984
41YES10.81784110
42NEK60.78309195
43SGK20.76707835
44RPS6KA40.75274286
45TYRO30.75027958
46PDGFRB0.71620665
47MAP3K20.71492975
48DYRK20.64559291
49SGK4940.63767425
50SGK2230.63767425
51CAMK40.62151936
52WNK10.62044269
53BMPR1B0.60969951
54WNK40.60079372
55TRIM280.57673531
56STK390.52853069
57FES0.52518683
58DAPK20.49206680
59NLK0.48647240
60TRPM70.47970576
61PRKG10.47638085
62WEE10.45825464
63PDK10.42691516
64KIT0.40969596
65UHMK10.40631833
66ROCK20.40607591
67GSK3B0.40121233
68BRSK10.38405409
69PRKCG0.38245537
70PDPK10.37274691
71STK110.36926012
72RPS6KA20.35429746
73ADRBK20.33588574
74CDK40.33240349
75GRK10.31591646
76ADRBK10.31043616
77NTRK10.30626941
78MAPK140.30620538
79CCNB10.30303763
80DYRK30.29923454
81CDK70.28836192
82SGK10.28220306
83CAMK2A0.27188095
84PRKCE0.26896225
85SGK30.26631066
86PRKCB0.26576102
87NEK20.26534897
88PRKG20.26099640
89VRK10.24799550
90PRKD20.24655422
91CDK10.23867748
92KSR10.22118412
93MAPK80.22074945
94CAMK1D0.21754707
95CDK50.21406061
96MINK10.21316019
97MAP3K90.20489126
98MAPK10.19843079
99PRKD10.18452117
100MST1R0.17729346

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.94983848
2Fatty acid biosynthesis_Homo sapiens_hsa000614.95707549
3Butanoate metabolism_Homo sapiens_hsa006502.88631050
4Olfactory transduction_Homo sapiens_hsa047402.60179296
5Fatty acid metabolism_Homo sapiens_hsa012122.37547490
6Taste transduction_Homo sapiens_hsa047422.21168519
7PPAR signaling pathway_Homo sapiens_hsa033202.21007276
8Glycerophospholipid metabolism_Homo sapiens_hsa005641.80525655
9Glutamatergic synapse_Homo sapiens_hsa047241.77706618
10Morphine addiction_Homo sapiens_hsa050321.73364164
11Fatty acid degradation_Homo sapiens_hsa000711.70174635
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62357571
13Circadian entrainment_Homo sapiens_hsa047131.50846275
14Complement and coagulation cascades_Homo sapiens_hsa046101.48897745
15Circadian rhythm_Homo sapiens_hsa047101.47732422
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46585608
17Phototransduction_Homo sapiens_hsa047441.44035300
18Nicotine addiction_Homo sapiens_hsa050331.42782335
19RNA transport_Homo sapiens_hsa030131.42420959
20Dorso-ventral axis formation_Homo sapiens_hsa043201.41373944
21Selenocompound metabolism_Homo sapiens_hsa004501.37104270
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36492338
23Fanconi anemia pathway_Homo sapiens_hsa034601.27571940
24Renin secretion_Homo sapiens_hsa049241.16564238
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16141590
26GABAergic synapse_Homo sapiens_hsa047271.13289601
27Serotonergic synapse_Homo sapiens_hsa047261.08859701
28Long-term depression_Homo sapiens_hsa047301.07856431
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.04660752
30Non-homologous end-joining_Homo sapiens_hsa034501.04458579
31Adipocytokine signaling pathway_Homo sapiens_hsa049201.01425488
32cAMP signaling pathway_Homo sapiens_hsa040241.01299928
33Vascular smooth muscle contraction_Homo sapiens_hsa042700.98694454
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93758272
35Cocaine addiction_Homo sapiens_hsa050300.91340828
36Calcium signaling pathway_Homo sapiens_hsa040200.90960913
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90185143
38Amphetamine addiction_Homo sapiens_hsa050310.89388567
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89291162
40Gap junction_Homo sapiens_hsa045400.89185050
41Tryptophan metabolism_Homo sapiens_hsa003800.86655887
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86266574
43ABC transporters_Homo sapiens_hsa020100.86170840
44Chemical carcinogenesis_Homo sapiens_hsa052040.81578318
45Glycerolipid metabolism_Homo sapiens_hsa005610.81210791
46Oocyte meiosis_Homo sapiens_hsa041140.77248503
47Propanoate metabolism_Homo sapiens_hsa006400.76556073
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74867544
49Fat digestion and absorption_Homo sapiens_hsa049750.74118041
50Dopaminergic synapse_Homo sapiens_hsa047280.74107468
51Ovarian steroidogenesis_Homo sapiens_hsa049130.72991422
52Glutathione metabolism_Homo sapiens_hsa004800.71840453
53Platelet activation_Homo sapiens_hsa046110.71087000
54Type II diabetes mellitus_Homo sapiens_hsa049300.71076329
55Salivary secretion_Homo sapiens_hsa049700.70769916
56Linoleic acid metabolism_Homo sapiens_hsa005910.69981107
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68148445
58Gastric acid secretion_Homo sapiens_hsa049710.67557367
59Axon guidance_Homo sapiens_hsa043600.66911256
60Oxytocin signaling pathway_Homo sapiens_hsa049210.65571361
61Tight junction_Homo sapiens_hsa045300.64483397
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61857467
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60341658
64RNA degradation_Homo sapiens_hsa030180.60247679
65Endocytosis_Homo sapiens_hsa041440.59163898
66Estrogen signaling pathway_Homo sapiens_hsa049150.58670329
67Synaptic vesicle cycle_Homo sapiens_hsa047210.57731086
68Inositol phosphate metabolism_Homo sapiens_hsa005620.57668073
69Focal adhesion_Homo sapiens_hsa045100.56605716
70Phenylalanine metabolism_Homo sapiens_hsa003600.56597135
71Protein digestion and absorption_Homo sapiens_hsa049740.55190803
72ECM-receptor interaction_Homo sapiens_hsa045120.52705346
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50757493
74Mismatch repair_Homo sapiens_hsa034300.50609665
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48129583
76Cholinergic synapse_Homo sapiens_hsa047250.47392409
77Ether lipid metabolism_Homo sapiens_hsa005650.47364489
78Caffeine metabolism_Homo sapiens_hsa002320.46134596
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46028646
80Long-term potentiation_Homo sapiens_hsa047200.45209213
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.41986789
82Insulin secretion_Homo sapiens_hsa049110.41377765
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41088912
84Ras signaling pathway_Homo sapiens_hsa040140.40504087
85Homologous recombination_Homo sapiens_hsa034400.38762550
86Alcoholism_Homo sapiens_hsa050340.38420811
87MAPK signaling pathway_Homo sapiens_hsa040100.38081289
88Arginine and proline metabolism_Homo sapiens_hsa003300.37580142
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37152680
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36884212
91Basal transcription factors_Homo sapiens_hsa030220.36620911
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36557218
93Choline metabolism in cancer_Homo sapiens_hsa052310.36528812
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36080445
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35477040
96Type I diabetes mellitus_Homo sapiens_hsa049400.33388640
97Thyroid hormone synthesis_Homo sapiens_hsa049180.33189360
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32916706
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31477289
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29412756

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