ARNT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)8.32226014
2polyketide metabolic process (GO:0030638)8.32226014
3doxorubicin metabolic process (GO:0044598)8.32226014
4regulation of RIG-I signaling pathway (GO:0039535)6.65868222
5regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)5.65870259
6positive regulation of fibroblast migration (GO:0010763)5.61757702
7aminoglycoside antibiotic metabolic process (GO:0030647)5.11125113
8negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)5.09278414
9nerve growth factor signaling pathway (GO:0038180)4.97918131
10regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.38791854
11regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.36485825
12detection of molecule of bacterial origin (GO:0032490)4.01693522
13CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.94194104
14T-helper cell differentiation (GO:0042093)3.94194104
15peptidyl-lysine dimethylation (GO:0018027)3.93031337
16positive regulation of granulocyte differentiation (GO:0030854)3.92568186
17positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.89821109
18negative regulation of T cell mediated immunity (GO:0002710)3.88573028
19positive regulation of natural killer cell mediated immunity (GO:0002717)3.87415896
20mRNA cleavage (GO:0006379)3.80215972
21regulation of T cell chemotaxis (GO:0010819)3.66257811
22positive regulation of T cell chemotaxis (GO:0010820)3.66257811
23interkinetic nuclear migration (GO:0022027)3.59225436
24regulation of T cell cytokine production (GO:0002724)3.57226376
25positive regulation of gamma-delta T cell activation (GO:0046645)3.47276100
26positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.40441949
27regulation of natural killer cell mediated immunity (GO:0002715)3.39159944
28regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.39159944
29regulation of memory T cell differentiation (GO:0043380)3.38800590
30negative regulation of heart rate (GO:0010459)3.38237996
31alpha-beta T cell differentiation involved in immune response (GO:0002293)3.36972414
32alpha-beta T cell activation involved in immune response (GO:0002287)3.36972414
33T cell differentiation involved in immune response (GO:0002292)3.36972414
34positive regulation of T cell cytokine production (GO:0002726)3.36492561
35NIK/NF-kappaB signaling (GO:0038061)3.35148919
36positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.31993430
37negative regulation of interleukin-2 production (GO:0032703)3.28914917
38negative regulation of alpha-beta T cell activation (GO:0046636)3.27886015
39positive regulation of SMAD protein import into nucleus (GO:0060391)3.27460244
40response to nerve growth factor (GO:1990089)3.26442794
41cellular response to nerve growth factor stimulus (GO:1990090)3.26442794
42pyrimidine ribonucleoside catabolic process (GO:0046133)3.12265844
43cellular response to nicotine (GO:0071316)3.11913199
44positive regulation of p38MAPK cascade (GO:1900745)3.08839257
45negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.07085025
46negative regulation of T-helper cell differentiation (GO:0045623)3.07085025
47negative regulation of complement activation (GO:0045916)3.06916948
48regulation of lymphocyte chemotaxis (GO:1901623)3.06637901
49definitive hemopoiesis (GO:0060216)3.05479314
50regulation of glomerular filtration (GO:0003093)3.05194684
51regulation of gamma-delta T cell differentiation (GO:0045586)3.04655678
52regulation of T cell tolerance induction (GO:0002664)3.03885446
53positive regulation of histone deacetylation (GO:0031065)3.02649122
54apoptotic cell clearance (GO:0043277)3.01900239
55regulation of leukocyte mediated cytotoxicity (GO:0001910)3.01343944
56regulation of gamma-delta T cell activation (GO:0046643)2.97256088
57response to interleukin-15 (GO:0070672)2.96601266
58negative regulation of lymphocyte mediated immunity (GO:0002707)2.96398088
59embryonic retina morphogenesis in camera-type eye (GO:0060059)2.95822110
60negative regulation of protein activation cascade (GO:2000258)2.95395622
61negative regulation of cytokine production involved in immune response (GO:0002719)2.94041426
62positive regulation of cell killing (GO:0031343)2.92876102
63negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.92583993
64positive regulation of fatty acid beta-oxidation (GO:0032000)2.91862885
65insulin-like growth factor receptor signaling pathway (GO:0048009)2.87487386
66positive regulation of T cell mediated cytotoxicity (GO:0001916)2.84390049
67paraxial mesoderm development (GO:0048339)2.84188679
68radial glial cell differentiation (GO:0060019)2.82394267
69positive regulation of T-helper 1 type immune response (GO:0002827)2.80156616
70L-fucose catabolic process (GO:0042355)2.79649824
71fucose catabolic process (GO:0019317)2.79649824
72L-fucose metabolic process (GO:0042354)2.79649824
73negative regulation of macroautophagy (GO:0016242)2.79479088
74cytidine metabolic process (GO:0046087)2.78663630
75cytidine catabolic process (GO:0006216)2.78663630
76cytidine deamination (GO:0009972)2.78663630
77CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.78387105
78histone H3-K9 modification (GO:0061647)2.77509017
79regulation of p38MAPK cascade (GO:1900744)2.76227388
80regulation of SMAD protein import into nucleus (GO:0060390)2.76184195
81negative regulation of adaptive immune response (GO:0002820)2.75959430
82necroptotic process (GO:0070266)2.75869775
83negative regulation of glycoprotein biosynthetic process (GO:0010561)2.75785846
84imidazole-containing compound metabolic process (GO:0052803)2.75690978
85cellular response to interleukin-15 (GO:0071350)2.73359189
86lymphocyte chemotaxis (GO:0048247)2.72764512
87endothelium development (GO:0003158)2.72504518
88regulation of cholesterol homeostasis (GO:2000188)2.71764937
89regulation of cell killing (GO:0031341)2.70785922
90histone H3-K9 demethylation (GO:0033169)2.70524969
91NLS-bearing protein import into nucleus (GO:0006607)2.70199311
92positive regulation of transforming growth factor beta production (GO:0071636)2.69901239
93positive regulation of circadian rhythm (GO:0042753)2.69701988
94regulation of tolerance induction (GO:0002643)2.67888636
95regulation of T cell mediated cytotoxicity (GO:0001914)2.65404640
96pre-miRNA processing (GO:0031054)2.63731828
97post-embryonic morphogenesis (GO:0009886)2.63239464
98response to water (GO:0009415)2.60870834
99vascular endothelial growth factor signaling pathway (GO:0038084)2.59761464
100venous blood vessel morphogenesis (GO:0048845)2.59405906
101cytoplasmic mRNA processing body assembly (GO:0033962)2.58401027
102negative regulation of humoral immune response (GO:0002921)2.57917591
103regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.57707680
104regulation of B cell receptor signaling pathway (GO:0050855)2.57293860
105negative regulation of production of molecular mediator of immune response (GO:0002701)2.56831831
106positive regulation of vasculogenesis (GO:2001214)2.56283586
107histone H3-K36 demethylation (GO:0070544)2.56080648
108regulation of tight junction assembly (GO:2000810)2.55890164
109mitotic sister chromatid cohesion (GO:0007064)2.53827514
110growth hormone receptor signaling pathway (GO:0060396)2.52522964
111regulation of granulocyte differentiation (GO:0030852)2.47814917
112glandular epithelial cell development (GO:0002068)2.47703404
113protein hydroxylation (GO:0018126)2.45677870
114positive regulation of defense response to virus by host (GO:0002230)2.45446105
115activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.43860665
116regulation of necroptotic process (GO:0060544)2.43423763
117protein heterotrimerization (GO:0070208)2.43265420
118CD4-positive, alpha-beta T cell activation (GO:0035710)2.43187360
119regulation of fatty acid beta-oxidation (GO:0031998)2.42976799
120hippo signaling (GO:0035329)2.42150495
121positive regulation of natural killer cell differentiation (GO:0032825)2.42048117
122regulation of alpha-beta T cell proliferation (GO:0046640)2.38369688
123cellular response to interleukin-4 (GO:0071353)2.38262342
124positive regulation of alpha-beta T cell proliferation (GO:0046641)2.37697199
125positive regulation of type 2 immune response (GO:0002830)2.37183259
126collagen fibril organization (GO:0030199)2.36164858
127regulation of T-helper 1 type immune response (GO:0002825)2.34949567
128detection of external biotic stimulus (GO:0098581)2.34571386
129tooth mineralization (GO:0034505)2.34446439
130regulation of integrin activation (GO:0033623)2.34029567
131regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.33968618
132alpha-linolenic acid metabolic process (GO:0036109)2.33938509
133type B pancreatic cell development (GO:0003323)2.33670295
134cell migration involved in sprouting angiogenesis (GO:0002042)2.33169841
135macroautophagy (GO:0016236)2.33164587
136positive regulation of B cell differentiation (GO:0045579)2.33019124
137negative regulation of histone methylation (GO:0031061)2.32879050
138lateral ventricle development (GO:0021670)2.32441550
139positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.32345639
140positive regulation of nuclease activity (GO:0032075)2.31789850
141protein carboxylation (GO:0018214)2.29380456
142peptidyl-glutamic acid carboxylation (GO:0017187)2.29380456
143cytolysis (GO:0019835)2.29377785
144regulation of lymphocyte mediated immunity (GO:0002706)2.29114701
145glucocorticoid receptor signaling pathway (GO:0042921)2.28898449
146negative regulation of meiosis (GO:0045835)2.28248054
147plasma membrane repair (GO:0001778)2.28022711
148renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.27942852
149basement membrane organization (GO:0071711)2.27604803
150craniofacial suture morphogenesis (GO:0097094)2.26248761
151regulation of T cell mediated immunity (GO:0002709)2.26179315
152positive regulation of macroautophagy (GO:0016239)2.26083950
153renal system process involved in regulation of blood volume (GO:0001977)2.26053997
154blood circulation (GO:0008015)2.25643174
155germinal center formation (GO:0002467)2.25624335
156cell adhesion mediated by integrin (GO:0033627)2.25389498
157cell-substrate junction assembly (GO:0007044)2.24275557
158positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.23883350
159regulation of cholesterol storage (GO:0010885)2.23387380
160iron ion import (GO:0097286)2.22860635
161lysine metabolic process (GO:0006553)2.22497859
162lysine catabolic process (GO:0006554)2.22497859
163regulation of complement activation (GO:0030449)2.21882610
164planar cell polarity pathway involved in neural tube closure (GO:0090179)2.21072926
165phospholipid homeostasis (GO:0055091)2.20980683
166carnitine shuttle (GO:0006853)2.18980272
167regulation of protein polyubiquitination (GO:1902914)2.18944050
168fatty acid transmembrane transport (GO:1902001)2.17372826
1694-hydroxyproline metabolic process (GO:0019471)2.17253873
170cell proliferation involved in metanephros development (GO:0072203)2.17111096
171adherens junction assembly (GO:0034333)2.17080352
172Golgi transport vesicle coating (GO:0048200)2.16677974
173COPI coating of Golgi vesicle (GO:0048205)2.16677974
174* embryonic placenta development (GO:0001892)2.15781454
175epithelial cell fate commitment (GO:0072148)2.15560052
176regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.15512137
177endodermal cell differentiation (GO:0035987)2.15302537
178low-density lipoprotein particle clearance (GO:0034383)2.13645785
179positive regulation of fatty acid oxidation (GO:0046321)2.13599004
180heart morphogenesis (GO:0003007)2.12821969
181nuclear pore organization (GO:0006999)2.12744370
182negative regulation of cell size (GO:0045792)2.12681766
183embryonic camera-type eye morphogenesis (GO:0048596)2.12435831
184cellular response to growth hormone stimulus (GO:0071378)2.12377166
185regulation of translational fidelity (GO:0006450)2.12283899
186detection of biotic stimulus (GO:0009595)2.11459894
187focal adhesion assembly (GO:0048041)2.10721847
188cell-substrate adherens junction assembly (GO:0007045)2.10721847
189drug catabolic process (GO:0042737)2.09956550
190nuclear pore complex assembly (GO:0051292)2.09539267
191mRNA stabilization (GO:0048255)2.08911876
192RNA stabilization (GO:0043489)2.08911876
193regulation of nuclease activity (GO:0032069)2.08867475
194L-alpha-amino acid transmembrane transport (GO:1902475)2.08806432
195cranial suture morphogenesis (GO:0060363)2.08771006
196regulation of extracellular matrix disassembly (GO:0010715)2.07683406
197protein localization to cell surface (GO:0034394)2.07600723
198negative regulation of granulocyte differentiation (GO:0030853)2.07447189

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.19629270
2* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.94013848
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.13990047
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.13452947
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.99917502
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.80779435
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.74399587
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.65079663
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.60210094
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.58181401
11CLOCK_20551151_ChIP-Seq_293T_Human2.47716289
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.46299047
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.41619380
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.41244995
15E2F7_22180533_ChIP-Seq_HELA_Human2.39166250
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.38375599
17ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.34285582
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.27474543
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.21860688
20MYC_22102868_ChIP-Seq_BL_Human2.17792257
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.17052834
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.15406516
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.12272422
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.11981597
25SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.11913037
26MYB_26560356_Chip-Seq_TH2_Human2.10215382
27IRF8_21731497_ChIP-ChIP_J774_Mouse2.09611477
28* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.01895127
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.00024348
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.99483726
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.99018641
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97592124
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.94900117
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.94726326
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.88699584
36TCF7_22412390_ChIP-Seq_EML_Mouse1.86073141
37* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.83590537
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.79494069
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70131554
40CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.69734344
41DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.69171341
42RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.65382610
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65162170
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.64499710
45* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.63407278
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60362985
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.60167085
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58003468
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.57885128
50MYB_26560356_Chip-Seq_TH1_Human1.56278312
51* KDM2B_26808549_Chip-Seq_DND41_Human1.55085615
52* SPI1_23127762_ChIP-Seq_K562_Human1.53475072
53ZFP281_27345836_Chip-Seq_ESCs_Mouse1.52379319
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.52354915
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51409770
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.50732391
57HIF1A_21447827_ChIP-Seq_MCF-7_Human1.50478944
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49074251
59SPI1_23547873_ChIP-Seq_NB4_Human1.48829880
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48070357
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.47472345
62TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47457624
63TBX20_22080862_ChIP-Seq_HEART_Mouse1.47380052
64TBX20_22328084_ChIP-Seq_HEART_Mouse1.47380052
65SCL_19346495_ChIP-Seq_HPC-7_Human1.46455674
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45999190
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45041371
68GATA3_27048872_Chip-Seq_THYMUS_Human1.44465878
69SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44403395
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43108473
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.43063208
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43039411
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41887947
74FOXA2_19822575_ChIP-Seq_HepG2_Human1.41560109
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41438333
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41126400
77WT1_19549856_ChIP-ChIP_CCG9911_Human1.36390849
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36320017
79VDR_24787735_ChIP-Seq_THP-1_Human1.34194921
80GATA2_19941826_ChIP-Seq_K562_Human1.33203212
81STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32509025
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.32469430
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32188732
84* GATA3_26560356_Chip-Seq_TH2_Human1.32122734
85TRIM28_21343339_ChIP-Seq_HEK293_Human1.31943416
86BRD4_25478319_ChIP-Seq_HGPS_Human1.31917883
87* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31331260
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30615469
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28940357
90* NCOR1_26117541_ChIP-Seq_K562_Human1.28321936
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.28260728
92GATA2_21666600_ChIP-Seq_HMVEC_Human1.27608252
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.27475489
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.27475489
95KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.27475489
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26981567
97PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26692464
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24666651
99* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24652285
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.23467878
101GATA1_19941826_ChIP-Seq_K562_Human1.20606500
102* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.20595208
103LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20582619
104* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20539192
105EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19755346
106VDR_21846776_ChIP-Seq_THP-1_Human1.19495959
107SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19479530
108CRX_20693478_ChIP-Seq_RETINA_Mouse1.19454335
109PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19430346
110GATA1_22025678_ChIP-Seq_K562_Human1.19196928
111* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18598216
112FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.17520281
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17339850
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17297297
115RACK7_27058665_Chip-Seq_MCF-7_Human1.17268971
116* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17175215
117CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16901757
118PU_27001747_Chip-Seq_BMDM_Mouse1.15117260
119NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14944351
120* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.14444168
121* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14436733
122AHR_22903824_ChIP-Seq_MCF-7_Human1.13567024
123* GATA6_25053715_ChIP-Seq_YYC3_Human1.11871392
124KDM2B_26808549_Chip-Seq_K562_Human1.11603143
125FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.11490745
126POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11380777
127ISL1_27105846_Chip-Seq_CPCs_Mouse1.10712486
128* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10520005
129TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10383489
130KDM2B_26808549_Chip-Seq_JURKAT_Human1.10335828
131OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10066589
132TCF4_18268006_ChIP-ChIP_LS174T_Human1.10054983
133ATF3_27146783_Chip-Seq_COLON_Human1.09346215
134UBF1/2_26484160_Chip-Seq_HMECs_Human1.09337113
135RXR_22108803_ChIP-Seq_LS180_Human1.08995253
136TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08251839
137* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07814064
138NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07720690
139EP300_21415370_ChIP-Seq_HL-1_Mouse1.07527484
140UTX_26944678_Chip-Seq_JUKART_Human1.07236000
141SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06796918
142ESR1_20079471_ChIP-ChIP_T-47D_Human1.06318668
143RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05565369
144HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05042457
145SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04363154
146LXR_22292898_ChIP-Seq_THP-1_Human1.03898660
147EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03081533
148* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02762278
149RUNX_20019798_ChIP-Seq_JUKART_Human1.02205864
150Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01971532
151LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01903346
152MAF_26560356_Chip-Seq_TH1_Human1.00602652
153SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00583253
154IRF8_22096565_ChIP-ChIP_GC-B_Human0.99317131
155BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98743366
156ER_23166858_ChIP-Seq_MCF-7_Human0.98649888
157RUNX1_22412390_ChIP-Seq_EML_Mouse0.98610019
158E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98434937
159CDX2_22108803_ChIP-Seq_LS180_Human0.98266102
160SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96777681
161SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96777681
162SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95478189
163NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95151365
164* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95102924
165ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94102893
166RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92559129
167GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91678492
168SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91552867
169ARNT_22903824_ChIP-Seq_MCF-7_Human0.91133135
170OCT4_18555785_Chip-Seq_ESCs_Mouse0.89852157
171EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89776450
172* GATA6_21074721_ChIP-Seq_CACO-2_Human0.89496498
173VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88020172
174PU1_27457419_Chip-Seq_LIVER_Mouse0.86806761
175P53_22387025_ChIP-Seq_ESCs_Mouse0.86135782
176MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.86064968

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.75797534
2MP0008438_abnormal_cutaneous_collagen3.55328787
3MP0003303_peritoneal_inflammation2.91311349
4MP0003724_increased_susceptibility_to2.85698762
5MP0000372_irregular_coat_pigmentation2.63734489
6MP0004381_abnormal_hair_follicle2.37846795
7MP0003878_abnormal_ear_physiology2.37212206
8MP0005377_hearing/vestibular/ear_phenot2.37212206
9MP0005275_abnormal_skin_tensile2.34174775
10MP0006082_CNS_inflammation2.24113481
11MP0005503_abnormal_tendon_morphology2.21050007
12MP0003566_abnormal_cell_adhesion2.20439853
13MP0003252_abnormal_bile_duct2.20415368
14MP0005075_abnormal_melanosome_morpholog2.18618623
15MP0002877_abnormal_melanocyte_morpholog2.17470035
16MP0010352_gastrointestinal_tract_polyps2.16477373
17MP0003279_aneurysm2.14071439
18MP0003172_abnormal_lysosome_physiology2.13733050
19MP0003300_gastrointestinal_ulcer2.08857961
20MP0005076_abnormal_cell_differentiation2.06788809
21MP0002166_altered_tumor_susceptibility2.01975553
22MP0002254_reproductive_system_inflammat1.98707924
23MP0004185_abnormal_adipocyte_glucose1.97489297
24* MP0005387_immune_system_phenotype1.95804500
25* MP0001790_abnormal_immune_system1.95804500
26MP0001873_stomach_inflammation1.93991568
27MP0008004_abnormal_stomach_pH1.91415864
28MP0001835_abnormal_antigen_presentation1.88023753
29MP0000685_abnormal_immune_system1.87854080
30MP0008260_abnormal_autophagy1.87400362
31MP0000733_abnormal_muscle_development1.82793207
32MP0005257_abnormal_intraocular_pressure1.82471990
33MP0001800_abnormal_humoral_immune1.78332120
34MP0002009_preneoplasia1.78050662
35MP0005671_abnormal_response_to1.76323791
36MP0003763_abnormal_thymus_physiology1.75581920
37MP0003045_fibrosis1.73919027
38MP0003195_calcinosis1.71204917
39MP0002139_abnormal_hepatobiliary_system1.69661976
40MP0005365_abnormal_bile_salt1.69544722
41MP0005451_abnormal_body_composition1.65682978
42MP0004233_abnormal_muscle_weight1.65427394
43MP0005666_abnormal_adipose_tissue1.61938624
44MP0005670_abnormal_white_adipose1.60192178
45MP0003191_abnormal_cellular_cholesterol1.55629026
46MP0002723_abnormal_immune_serum1.54157599
47MP0002405_respiratory_system_inflammati1.53264729
48MP0005464_abnormal_platelet_physiology1.53193092
49MP0002148_abnormal_hypersensitivity_rea1.53177429
50MP0004510_myositis1.53110836
51MP0005000_abnormal_immune_tolerance1.52894522
52MP0010307_abnormal_tumor_latency1.47914561
53MP0002452_abnormal_antigen_presenting1.47659480
54MP0002419_abnormal_innate_immunity1.46319997
55MP0002420_abnormal_adaptive_immunity1.46215254
56MP0004272_abnormal_basement_membrane1.45952190
57MP0005023_abnormal_wound_healing1.44164041
58MP0004084_abnormal_cardiac_muscle1.43902345
59MP0005085_abnormal_gallbladder_physiolo1.43252326
60MP0010234_abnormal_vibrissa_follicle1.43234298
61MP0001819_abnormal_immune_cell1.42485513
62MP0010368_abnormal_lymphatic_system1.39776203
63MP0000003_abnormal_adipose_tissue1.38695809
64MP0005375_adipose_tissue_phenotype1.38154553
65MP0004484_altered_response_of1.32693493
66MP0010329_abnormal_lipoprotein_level1.32375521
67MP0001851_eye_inflammation1.30799633
68MP0009333_abnormal_splenocyte_physiolog1.29213434
69MP0003656_abnormal_erythrocyte_physiolo1.26904456
70MP0000689_abnormal_spleen_morphology1.24132270
71MP0001853_heart_inflammation1.24094670
72MP0005058_abnormal_lysosome_morphology1.23973375
73MP0002108_abnormal_muscle_morphology1.23116773
74MP0003436_decreased_susceptibility_to1.21722528
75MP0005360_urolithiasis1.21258565
76MP0005025_abnormal_response_to1.21113495
77MP0000678_abnormal_parathyroid_gland1.17751649
78MP0002398_abnormal_bone_marrow1.17214371
79MP0002933_joint_inflammation1.15868868
80MP0002060_abnormal_skin_morphology1.15519535
81MP0010630_abnormal_cardiac_muscle1.13778560
82MP0000716_abnormal_immune_system1.13715305
83MP0004130_abnormal_muscle_cell1.13047748
84MP0001849_ear_inflammation1.12750673
85MP0005083_abnormal_biliary_tract1.12490942
86MP0008775_abnormal_heart_ventricle1.11809868
87MP0004087_abnormal_muscle_fiber1.11235144
88MP0008961_abnormal_basal_metabolism1.10175249
89MP0001845_abnormal_inflammatory_respons1.10015967
90MP0005367_renal/urinary_system_phenotyp1.08136365
91MP0000516_abnormal_urinary_system1.08136365
92MP0005310_abnormal_salivary_gland1.07938160
93* MP0000609_abnormal_liver_physiology1.07016841
94MP0002006_tumorigenesis1.06815760
95MP0002722_abnormal_immune_system1.06458899
96MP0002132_abnormal_respiratory_system1.06368386
97MP0000465_gastrointestinal_hemorrhage1.05216970
98MP0002928_abnormal_bile_duct1.04791287
99MP0001533_abnormal_skeleton_physiology1.04217727
100MP0003828_pulmonary_edema1.01466966
101MP0008469_abnormal_protein_level1.01380740
102MP0004947_skin_inflammation1.00881208
103MP0009780_abnormal_chondrocyte_physiolo1.00514611
104MP0002970_abnormal_white_adipose1.00142121
105MP0009278_abnormal_bone_marrow0.99710979
106MP0009384_cardiac_valve_regurgitation0.99034696
107MP0009053_abnormal_anal_canal0.98731521
108MP0002269_muscular_atrophy0.98520382
109* MP0002925_abnormal_cardiovascular_devel0.97632226
110MP0000750_abnormal_muscle_regeneration0.97600043
111MP0004197_abnormal_fetal_growth/weight/0.97091193
112MP0000569_abnormal_digit_pigmentation0.95309078
113MP0003091_abnormal_cell_migration0.95090072
114MP0002168_other_aberrant_phenotype0.94726528
115MP0003935_abnormal_craniofacial_develop0.93727118
116MP0002837_dystrophic_cardiac_calcinosis0.93638695
117* MP0002429_abnormal_blood_cell0.93496172
118MP0003567_abnormal_fetal_cardiomyocyte0.93294347
119MP0005508_abnormal_skeleton_morphology0.93263791
120MP0009785_altered_susceptibility_to0.92111647
121MP0000767_abnormal_smooth_muscle0.91538687
122MP0000703_abnormal_thymus_morphology0.90767936
123MP0006054_spinal_hemorrhage0.89573300
124MP0001661_extended_life_span0.88967200
125MP0009763_increased_sensitivity_to0.88726683
126MP0000759_abnormal_skeletal_muscle0.87668845
127MP0000428_abnormal_craniofacial_morphol0.87200188
128MP0001293_anophthalmia0.87134445
129MP0002128_abnormal_blood_circulation0.86901149
130MP0005408_hypopigmentation0.86327623
131MP0010155_abnormal_intestine_physiology0.85095542
132MP0005332_abnormal_amino_acid0.84623723
133MP0000266_abnormal_heart_morphology0.84372980
134MP0002896_abnormal_bone_mineralization0.84183859
135MP0001958_emphysema0.82209456
136MP0004883_abnormal_blood_vessel0.81643272
137MP0005248_abnormal_Harderian_gland0.81324147
138MP0009672_abnormal_birth_weight0.80043686
139MP0006138_congestive_heart_failure0.79081584
140* MP0002088_abnormal_embryonic_growth/wei0.78620985
141MP0003221_abnormal_cardiomyocyte_apopto0.78461432
142MP0009115_abnormal_fat_cell0.78234245
143MP0003950_abnormal_plasma_membrane0.78125239
144MP0009697_abnormal_copulation0.77855874
145MP0005623_abnormal_meninges_morphology0.77848217
146MP0003941_abnormal_skin_development0.77433464
147MP0003115_abnormal_respiratory_system0.76915935
148MP0000579_abnormal_nail_morphology0.76784404
149* MP0002086_abnormal_extraembryonic_tissu0.76498762
150MP0005164_abnormal_response_to0.76223806
151MP0000249_abnormal_blood_vessel0.75872059
152MP0010030_abnormal_orbit_morphology0.75794578
153* MP0003984_embryonic_growth_retardation0.75518585
154* MP0001614_abnormal_blood_vessel0.74433645
155MP0001879_abnormal_lymphatic_vessel0.73406384
156MP0001175_abnormal_lung_morphology0.73010221
157MP0002697_abnormal_eye_size0.72688946
158MP0000749_muscle_degeneration0.72448798
159MP0002098_abnormal_vibrissa_morphology0.72089765
160MP0001243_abnormal_dermal_layer0.71851950
161MP0002971_abnormal_brown_adipose0.71431654
162MP0004808_abnormal_hematopoietic_stem0.71177913
163MP0004134_abnormal_chest_morphology0.71162368
164MP0003448_altered_tumor_morphology0.70752609
165* MP0003453_abnormal_keratinocyte_physiol0.70496214
166MP0009840_abnormal_foam_cell0.69991326
167MP0000371_diluted_coat_color0.69818857
168MP0002998_abnormal_bone_remodeling0.69571549
169MP0004036_abnormal_muscle_relaxation0.68737564
170MP0002138_abnormal_hepatobiliary_system0.68732056
171MP0003385_abnormal_body_wall0.68099957
172MP0000598_abnormal_liver_morphology0.67816691
173MP0005397_hematopoietic_system_phenotyp0.66437411

Predicted human phenotypes

RankGene SetZ-score
1Alopecia of scalp (HP:0002293)4.66916961
2Follicular hyperkeratosis (HP:0007502)4.39135215
3Arthropathy (HP:0003040)4.11202613
4Orthostatic hypotension (HP:0001278)3.98725412
5Protrusio acetabuli (HP:0003179)3.68974666
6Cerebral aneurysm (HP:0004944)3.51593130
7Anhidrosis (HP:0000970)3.44105877
8Unilateral renal agenesis (HP:0000122)3.43585825
9Episodic fever (HP:0001954)3.42279995
10Abnormality of T cell number (HP:0011839)3.34234921
11T lymphocytopenia (HP:0005403)3.33796844
12Chronic diarrhea (HP:0002028)3.22197099
13Bilateral sensorineural hearing impairment (HP:0008619)3.16466499
14Abnormality of polysaccharide metabolism (HP:0011012)3.11578121
15Abnormality of glycosaminoglycan metabolism (HP:0004371)3.11578121
16Abnormality of mucopolysaccharide metabolism (HP:0011020)3.11578121
17Shallow orbits (HP:0000586)3.09684049
18Lymphangioma (HP:0100764)3.07835235
19Increased connective tissue (HP:0009025)3.07552989
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.02156134
21Premature rupture of membranes (HP:0001788)3.00914232
22Broad metatarsal (HP:0001783)2.97927425
23Autoimmune hemolytic anemia (HP:0001890)2.97139753
24Abnormality of oral frenula (HP:0000190)2.96581717
25Gingival bleeding (HP:0000225)2.95883824
26Urinary glycosaminoglycan excretion (HP:0003541)2.90457567
27Mucopolysacchariduria (HP:0008155)2.90457567
28Increased CSF protein (HP:0002922)2.87793630
29Aortic aneurysm (HP:0004942)2.83148385
30Ankle contracture (HP:0006466)2.79635839
31Autoamputation (HP:0001218)2.77455939
32Spontaneous hematomas (HP:0007420)2.73337665
33Mitral stenosis (HP:0001718)2.73080724
34Slow saccadic eye movements (HP:0000514)2.71558772
35Exostoses (HP:0100777)2.70036135
36Type 1 muscle fiber predominance (HP:0003803)2.69652840
37Gastrointestinal infarctions (HP:0005244)2.68120799
38Aneurysm (HP:0002617)2.62089040
39Abnormality of macrophages (HP:0004311)2.58128869
40Aortic dissection (HP:0002647)2.57379149
41Prolonged bleeding time (HP:0003010)2.55503643
42Dysostosis multiplex (HP:0000943)2.54666603
43Ulnar bowing (HP:0003031)2.50938993
44Mitral valve prolapse (HP:0001634)2.45680458
45Cervical subluxation (HP:0003308)2.40138347
46Dysmetric saccades (HP:0000641)2.38057492
47Stomatitis (HP:0010280)2.37718377
48Recurrent cutaneous fungal infections (HP:0011370)2.35160699
49Chronic mucocutaneous candidiasis (HP:0002728)2.35160699
50Joint swelling (HP:0001386)2.34693620
51Rectal prolapse (HP:0002035)2.33744216
52Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.33464533
53Short 4th metacarpal (HP:0010044)2.33464533
54Absent eyelashes (HP:0000561)2.28582630
55Hematochezia (HP:0002573)2.27750501
56Dysautonomia (HP:0002459)2.27290378
57Abnormality of T cells (HP:0002843)2.26816524
58Deep venous thrombosis (HP:0002625)2.23009231
59Hypoplastic ischia (HP:0003175)2.22771209
60Dilatation of the ascending aorta (HP:0005111)2.22134923
61Widely spaced teeth (HP:0000687)2.21733218
62Abnormality of iron homeostasis (HP:0011031)2.21172406
63Abnormality of transition element cation homeostasis (HP:0011030)2.20993248
64Myocardial infarction (HP:0001658)2.20947369
65Long eyelashes (HP:0000527)2.20072905
66Abnormality of liposaccharide metabolism (HP:0010968)2.19809620
67Abnormality of glycosphingolipid metabolism (HP:0004343)2.19809620
68Abnormality of glycolipid metabolism (HP:0010969)2.19809620
69Genu recurvatum (HP:0002816)2.18926351
70Mediastinal lymphadenopathy (HP:0100721)2.18536504
71Narrow palate (HP:0000189)2.18519217
72Macroorchidism (HP:0000053)2.18098056
73Abnormality of T cell physiology (HP:0011840)2.17279710
74Thyroid carcinoma (HP:0002890)2.16934398
75Recurrent gram-negative bacterial infections (HP:0005420)2.15979022
76Epistaxis (HP:0000421)2.15393493
77Autoimmune thrombocytopenia (HP:0001973)2.14039574
78Osteomyelitis (HP:0002754)2.11801297
79J-shaped sella turcica (HP:0002680)2.11437029
80Thyroiditis (HP:0100646)2.09676735
81Cholecystitis (HP:0001082)2.09428793
82Abnormal gallbladder physiology (HP:0012438)2.09428793
83Pulmonary infiltrates (HP:0002113)2.08847923
84Hyperammonemia (HP:0001987)2.08157184
85Arterial thrombosis (HP:0004420)2.08116358
86Prolonged partial thromboplastin time (HP:0003645)2.06240507
87Right ventricular cardiomyopathy (HP:0011663)2.04580810
88Myositis (HP:0100614)2.04176958
89Abnormality of the ischium (HP:0003174)2.03625315
90Hypoalphalipoproteinemia (HP:0003233)2.03597752
91Abnormality of the 4th metacarpal (HP:0010012)2.03597174
92Bladder diverticulum (HP:0000015)2.03553910
93Recurrent fungal infections (HP:0002841)2.02434847
94Abnormality of the renal cortex (HP:0011035)2.02129822
95Hypoproteinemia (HP:0003075)2.01816719
96Long toe (HP:0010511)2.01414876
97Albinism (HP:0001022)2.00687597
98Hyporeflexia of lower limbs (HP:0002600)2.00686476
99Dislocated radial head (HP:0003083)2.00066363
100Enlarged penis (HP:0000040)1.97637743
101Blepharitis (HP:0000498)1.97486566
102Joint hemorrhage (HP:0005261)1.97307754
103Mildly elevated creatine phosphokinase (HP:0008180)1.96961189
104Hypoplasia of the odontoid process (HP:0003311)1.96663629
105Glomerulonephritis (HP:0000099)1.95319187
106Genetic anticipation (HP:0003743)1.94816117
107Atrophic scars (HP:0001075)1.94652955
108Recurrent viral infections (HP:0004429)1.94311898
109Testicular neoplasm (HP:0010788)1.92159919
110Chest pain (HP:0100749)1.91889203
111Nemaline bodies (HP:0003798)1.91751377
112Eczematoid dermatitis (HP:0000976)1.91413403
113Duplicated collecting system (HP:0000081)1.91179828
114Absent eyebrow (HP:0002223)1.90992421
115Recurrent skin infections (HP:0001581)1.90930204
116Wrist flexion contracture (HP:0001239)1.90109492
117Impaired proprioception (HP:0010831)1.89571265
118Orchitis (HP:0100796)1.89256312
119Disproportionate tall stature (HP:0001519)1.88993383
120Recurrent abscess formation (HP:0002722)1.88786532
121Keratitis (HP:0000491)1.88684566
122Osteolytic defects of the phalanges of the hand (HP:0009771)1.88464812
123Osteolytic defects of the hand bones (HP:0009699)1.88464812
124Blue sclerae (HP:0000592)1.88451247
125Potter facies (HP:0002009)1.87902088
126Facial shape deformation (HP:0011334)1.87902088
127Exercise-induced myalgia (HP:0003738)1.87725977
128Optic neuritis (HP:0100653)1.86413510
129Retrobulbar optic neuritis (HP:0100654)1.86413510
130Increased serum ferritin (HP:0003281)1.85050932
131Hypotension (HP:0002615)1.82966703
132Scapular winging (HP:0003691)1.82665783
133Asymmetry of the thorax (HP:0001555)1.81243747
134Soft skin (HP:0000977)1.81006693
135Abnormality of the radial head (HP:0003995)1.79319062
136Recurrent bacterial skin infections (HP:0005406)1.78236046
137Abnormality of complement system (HP:0005339)1.78109433
138Abnormality of the fingertips (HP:0001211)1.75732182
139Bowing of the arm (HP:0006488)1.73309243
140Bowed forearm bones (HP:0003956)1.73309243
141Peritonitis (HP:0002586)1.71458884
142Coarse hair (HP:0002208)1.71222688
143Systemic lupus erythematosus (HP:0002725)1.71072377
144Muscle fiber inclusion bodies (HP:0100299)1.70577025
145Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.69594335
146Hyperglycemia (HP:0003074)1.69289731
147Bowel diverticulosis (HP:0005222)1.68870953
148Turricephaly (HP:0000262)1.68761602
149Keratoconjunctivitis (HP:0001096)1.68642667
150Inflammation of the large intestine (HP:0002037)1.68589650
151Asymmetric septal hypertrophy (HP:0001670)1.67579095
152Vasculitis (HP:0002633)1.67200722
153Spinal rigidity (HP:0003306)1.66120067
154Pseudobulbar signs (HP:0002200)1.65427461
155Spondylolisthesis (HP:0003302)1.65422177
156Hepatitis (HP:0012115)1.64883458
157Bile duct proliferation (HP:0001408)1.64237481
158Abnormal biliary tract physiology (HP:0012439)1.64237481
159Complement deficiency (HP:0004431)1.62960791
160Ectopia lentis (HP:0001083)1.62242080
161Aortic regurgitation (HP:0001659)1.61914698
162Recurrent corneal erosions (HP:0000495)1.59163059
163Difficulty running (HP:0009046)1.59130754
164Camptodactyly of toe (HP:0001836)1.58877787
165Cheilitis (HP:0100825)1.58857272
166Ependymoma (HP:0002888)1.58685802
167Increased variability in muscle fiber diameter (HP:0003557)1.58544501
168Abnormality of dental color (HP:0011073)1.56502939
169Striae distensae (HP:0001065)1.56491481
170Abnormality of the astrocytes (HP:0100707)1.55721495
171Astrocytoma (HP:0009592)1.55721495
172Renovascular hypertension (HP:0100817)1.55621480
173Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.54923461
174Vertebral arch anomaly (HP:0008438)1.54852434
175Abnormality of the peritoneum (HP:0002585)1.54005003
176Neoplasm of the respiratory system (HP:0100606)1.52627176
177Thin bony cortex (HP:0002753)1.52358481
178Bell-shaped thorax (HP:0001591)1.51509953
179Neoplasm of the lung (HP:0100526)1.50851298
180Upper limb amyotrophy (HP:0009129)1.49705638
181Distal upper limb amyotrophy (HP:0007149)1.49705638
182Tibial bowing (HP:0002982)1.49493019
183Hydroxyprolinuria (HP:0003080)1.49137151
184Abnormality of proline metabolism (HP:0010907)1.49137151
185Joint laxity (HP:0001388)1.49035536
186Parakeratosis (HP:0001036)1.47198442
187Abnormality of the common coagulation pathway (HP:0010990)1.46956701
188Skin nodule (HP:0200036)1.46919311
189Ectropion (HP:0000656)1.46770029
190Atrioventricular block (HP:0001678)1.46695814
191Coronal craniosynostosis (HP:0004440)1.46271771
192Urethral obstruction (HP:0000796)1.45748176
193Slender build (HP:0001533)1.45404319
194Abnormality of skeletal muscle fiber size (HP:0012084)1.45398010
195Exercise-induced muscle cramps (HP:0003710)1.44664712

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK14.70954569
2LATS13.73581739
3FES3.62942995
4MAPKAPK33.55250571
5CDK123.50159085
6TAOK13.41281727
7NLK3.25641213
8MATK3.13475896
9SIK32.96581674
10NTRK12.63518945
11TAOK22.61124391
12TRIB32.52150003
13TTN2.45048929
14MAP3K32.41752924
15EEF2K2.40557420
16ERN12.34187778
17SIK22.30321433
18RIPK12.22592164
19EPHA22.19167765
20PKN22.17487781
21CAMK1D2.17480265
22MAP4K12.01287274
23MAP3K111.90480289
24PDGFRA1.77189671
25MARK31.73539575
26CAMK1G1.66876756
27PTK61.65969879
28PAK41.63054539
29MAP3K101.61829612
30TXK1.58509463
31RIPK41.56704874
32BRD41.54444932
33TGFBR21.50076300
34MAP3K11.44307375
35ACVR1B1.43892525
36MAP3K141.43872671
37FGFR41.38993040
38STK31.38878520
39FRK1.34517694
40MTOR1.30508245
41FGFR31.25105564
42DDR21.21612165
43PIK3CG1.16882187
44KIT1.16060810
45MAP4K21.15702858
46FLT31.14277158
47FGFR21.14178322
48STK101.13466047
49BLK1.13061588
50CDK61.12626868
51MAP3K71.12122951
52TRIM281.11847977
53EPHB11.11664013
54STK38L1.10595530
55OBSCN1.09602851
56MAP3K131.06138804
57LATS21.04508108
58EPHA31.02287376
59BRSK21.01812333
60SGK30.99742952
61JAK10.96963301
62BMX0.93377516
63STK380.92458842
64PRKD20.91881690
65WNK10.91712458
66IKBKB0.89703136
67SYK0.89529693
68PTK20.86286149
69TNK20.85779037
70DMPK0.85588051
71CDK40.85190733
72MAPKAPK20.82320298
73PDGFRB0.81945996
74PRKAA20.81588605
75GRK60.81137194
76MAP3K50.81131052
77TYK20.80846154
78RPS6KA40.79027829
79GRK70.78187762
80NEK20.77311934
81LCK0.77249503
82NEK90.76980037
83PINK10.76637501
84ALK0.75958557
85MAPK110.75663491
86BTK0.75021242
87LYN0.74591999
88TRPM70.74377558
89TEC0.73253298
90MARK20.72818522
91TBK10.72646737
92TAOK30.72269813
93ZAP700.70583831
94ICK0.70017522
95MET0.68003925
96JAK30.67309934
97PTK2B0.66800590
98PIK3CA0.64305865
99FGFR10.63970401
100RPS6KB20.63429161
101HIPK20.63242159
102IRAK30.63055051
103CAMK40.61677627
104PRKAA10.60815309
105CAMKK20.59849501
106PRKCQ0.59669575
107IKBKE0.59659517
108PHKG20.58863286
109PHKG10.58863286
110PAK20.57933022
111CDC42BPA0.57160324
112INSRR0.56764874
113FER0.55815383
114AKT30.55508132
115BCKDK0.54918048
116CHUK0.54205011
117CDK90.53583812
118NEK10.53493986
119MST40.52290836
120CDK70.51981217
121MAP2K30.51139640
122CSNK1D0.50917143
123CSNK1A1L0.48279869
124STK40.47578136
125RET0.46891456
126YES10.46533828
127PRKCH0.46465913
128IRAK10.45530898
129MAPK70.45224648
130MAPK120.44675937
131JAK20.44468247
132PDK10.44180898
133CDC70.43251687
134MAP3K20.42665946
135MAPK10.42329502
136SGK20.40646385
137ADRBK20.40160940
138CSNK1G30.39226649
139MAP3K80.38745209
140PRKD10.38165594
141CSK0.37177167
142TTK0.37021596
143PIM10.36610082
144BMPR20.36043151
145MELK0.35383437
146CSF1R0.34115144
147LRRK20.33910948
148INSR0.33259336
149EIF2AK20.32638413
150CHEK10.32497571
151AKT10.31293131
152ERBB20.31216935
153MST1R0.30974441
154HCK0.30032901
155ITK0.29590708
156TIE10.29522062
157DYRK1B0.29118374

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.64706885
2Nitrogen metabolism_Homo sapiens_hsa009102.43586566
3Arginine biosynthesis_Homo sapiens_hsa002202.06496606
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.96598268
5Graft-versus-host disease_Homo sapiens_hsa053321.84703474
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.79793597
7Other glycan degradation_Homo sapiens_hsa005111.76378424
8Primary immunodeficiency_Homo sapiens_hsa053401.75579650
9Allograft rejection_Homo sapiens_hsa053301.72194183
10T cell receptor signaling pathway_Homo sapiens_hsa046601.69744867
11Complement and coagulation cascades_Homo sapiens_hsa046101.66146455
12Adherens junction_Homo sapiens_hsa045201.63225724
13Thyroid cancer_Homo sapiens_hsa052161.62250758
14Insulin resistance_Homo sapiens_hsa049311.60448727
15Autoimmune thyroid disease_Homo sapiens_hsa053201.58244367
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.58071054
17ECM-receptor interaction_Homo sapiens_hsa045121.56627053
18Malaria_Homo sapiens_hsa051441.54371390
19mTOR signaling pathway_Homo sapiens_hsa041501.52217845
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.51147405
21Measles_Homo sapiens_hsa051621.48259983
22Type I diabetes mellitus_Homo sapiens_hsa049401.47095130
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.46797282
24Caffeine metabolism_Homo sapiens_hsa002321.46661779
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.44192015
26Focal adhesion_Homo sapiens_hsa045101.42827447
27B cell receptor signaling pathway_Homo sapiens_hsa046621.39740229
28PPAR signaling pathway_Homo sapiens_hsa033201.38738744
29Staphylococcus aureus infection_Homo sapiens_hsa051501.38518668
30Small cell lung cancer_Homo sapiens_hsa052221.38316690
31Fatty acid degradation_Homo sapiens_hsa000711.34761583
32Linoleic acid metabolism_Homo sapiens_hsa005911.33950854
33Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.33843906
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.30168028
35Tryptophan metabolism_Homo sapiens_hsa003801.27962762
36Chronic myeloid leukemia_Homo sapiens_hsa052201.22879294
37Proteoglycans in cancer_Homo sapiens_hsa052051.22306092
38MicroRNAs in cancer_Homo sapiens_hsa052061.22029100
39Dilated cardiomyopathy_Homo sapiens_hsa054141.21827205
40Type II diabetes mellitus_Homo sapiens_hsa049301.21219865
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.20964872
42Hematopoietic cell lineage_Homo sapiens_hsa046401.19879282
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19153450
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18035800
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.16757463
46Regulation of autophagy_Homo sapiens_hsa041401.15218340
47Histidine metabolism_Homo sapiens_hsa003401.11153176
48Chemokine signaling pathway_Homo sapiens_hsa040621.08628214
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08304603
50Notch signaling pathway_Homo sapiens_hsa043301.07066023
51NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05601838
52Selenocompound metabolism_Homo sapiens_hsa004501.04472972
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01501542
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00271920
55ABC transporters_Homo sapiens_hsa020100.97268099
56Amoebiasis_Homo sapiens_hsa051460.97188502
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.96440806
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95850760
59AMPK signaling pathway_Homo sapiens_hsa041520.94810098
60Bile secretion_Homo sapiens_hsa049760.94004544
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93770638
62Renin-angiotensin system_Homo sapiens_hsa046140.92534417
63Acute myeloid leukemia_Homo sapiens_hsa052210.89858530
64Antigen processing and presentation_Homo sapiens_hsa046120.89247548
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89180266
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.88307589
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87572346
68Retinol metabolism_Homo sapiens_hsa008300.87208769
69Bladder cancer_Homo sapiens_hsa052190.86681741
70Pancreatic cancer_Homo sapiens_hsa052120.86456792
71Prostate cancer_Homo sapiens_hsa052150.86300191
72Herpes simplex infection_Homo sapiens_hsa051680.85128554
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84865162
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84270708
75Glucagon signaling pathway_Homo sapiens_hsa049220.84138170
76Toxoplasmosis_Homo sapiens_hsa051450.83463579
77Arachidonic acid metabolism_Homo sapiens_hsa005900.83207904
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.83027907
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82813608
80Legionellosis_Homo sapiens_hsa051340.82601907
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81833000
82FoxO signaling pathway_Homo sapiens_hsa040680.81668297
83Dorso-ventral axis formation_Homo sapiens_hsa043200.81385530
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80117630
85Melanoma_Homo sapiens_hsa052180.79948837
86Insulin signaling pathway_Homo sapiens_hsa049100.79028383
87Ether lipid metabolism_Homo sapiens_hsa005650.78878407
88Fatty acid metabolism_Homo sapiens_hsa012120.78852044
89Non-small cell lung cancer_Homo sapiens_hsa052230.78333275
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77931570
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.77790376
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.76821323
93Osteoclast differentiation_Homo sapiens_hsa043800.76472030
94Circadian rhythm_Homo sapiens_hsa047100.76336062
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75278645
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75193774
97Ovarian steroidogenesis_Homo sapiens_hsa049130.75002289
98One carbon pool by folate_Homo sapiens_hsa006700.74858793
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74810174
100Protein digestion and absorption_Homo sapiens_hsa049740.73748991
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73456370
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73158110
103HTLV-I infection_Homo sapiens_hsa051660.72431823
104Starch and sucrose metabolism_Homo sapiens_hsa005000.72338217
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71887522
106Viral myocarditis_Homo sapiens_hsa054160.70963900
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.70946143
108Apoptosis_Homo sapiens_hsa042100.70437444
109Basal cell carcinoma_Homo sapiens_hsa052170.70402599
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70355963
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69227128
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.68253233
113Fat digestion and absorption_Homo sapiens_hsa049750.67359988
114Endometrial cancer_Homo sapiens_hsa052130.64268716
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63833772
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.63604708
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62966469
118Hippo signaling pathway_Homo sapiens_hsa043900.61895168
119Galactose metabolism_Homo sapiens_hsa000520.61366454
120Biosynthesis of amino acids_Homo sapiens_hsa012300.60655624
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.59203433
122Fatty acid biosynthesis_Homo sapiens_hsa000610.59079432
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57911546
124Tuberculosis_Homo sapiens_hsa051520.57795137
125Hepatitis B_Homo sapiens_hsa051610.56802337
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56718658
127Mineral absorption_Homo sapiens_hsa049780.56675387
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55444021
129* Renal cell carcinoma_Homo sapiens_hsa052110.54728815
130Influenza A_Homo sapiens_hsa051640.54717595
131Pertussis_Homo sapiens_hsa051330.54621653
132Asthma_Homo sapiens_hsa053100.53640317
133TGF-beta signaling pathway_Homo sapiens_hsa043500.53421845
134Platelet activation_Homo sapiens_hsa046110.53239487
135Glioma_Homo sapiens_hsa052140.52908471
136Peroxisome_Homo sapiens_hsa041460.52766755
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52445654
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.51914982
139Glycerolipid metabolism_Homo sapiens_hsa005610.51351504
140* Pathways in cancer_Homo sapiens_hsa052000.51232901
141Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50702042
142Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49956748
143Sphingolipid metabolism_Homo sapiens_hsa006000.49830978
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48815856
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48393518
146TNF signaling pathway_Homo sapiens_hsa046680.47587662
147Prolactin signaling pathway_Homo sapiens_hsa049170.47444825
148Leishmaniasis_Homo sapiens_hsa051400.46602604
149p53 signaling pathway_Homo sapiens_hsa041150.46415661
150Lysosome_Homo sapiens_hsa041420.45987828
151* HIF-1 signaling pathway_Homo sapiens_hsa040660.45028067
152Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44404651
153N-Glycan biosynthesis_Homo sapiens_hsa005100.44182225
154Butanoate metabolism_Homo sapiens_hsa006500.44170768
155Choline metabolism in cancer_Homo sapiens_hsa052310.43853609
156* Chemical carcinogenesis_Homo sapiens_hsa052040.43454573

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