ARNTL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal rod cell development (GO:0046548)6.75717320
2retinal cone cell development (GO:0046549)5.83346431
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.41773122
4detection of light stimulus involved in sensory perception (GO:0050962)5.37191431
5detection of light stimulus involved in visual perception (GO:0050908)5.37191431
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.83114546
7regulation of B cell receptor signaling pathway (GO:0050855)4.82458102
8photoreceptor cell development (GO:0042461)4.80036993
9sodium ion export (GO:0071436)4.68942671
10eye photoreceptor cell development (GO:0042462)4.65089562
11antigen processing and presentation of endogenous antigen (GO:0019883)4.58847573
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.57207857
13cellular potassium ion homeostasis (GO:0030007)4.46964509
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.43015966
15response to interleukin-15 (GO:0070672)4.38173489
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.31741671
17rhodopsin mediated signaling pathway (GO:0016056)4.28307997
18cellular response to interleukin-15 (GO:0071350)4.25275547
19negative regulation of hormone biosynthetic process (GO:0032353)4.23934655
20negative regulation of hormone metabolic process (GO:0032351)4.23934655
21G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.23362806
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.18143405
23positive regulation by organism of defense response of other organism involved in symbiotic interact4.18143405
24modulation by symbiont of host immune response (GO:0052553)4.18143405
25positive regulation by symbiont of host defense response (GO:0052509)4.18143405
26modulation by symbiont of host defense response (GO:0052031)4.18143405
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.18143405
28regulation of rhodopsin mediated signaling pathway (GO:0022400)4.16539023
29synaptic vesicle docking involved in exocytosis (GO:0016081)4.15269230
30negative T cell selection (GO:0043383)4.06294465
31negative regulation of lymphocyte mediated immunity (GO:0002707)4.04676520
32detection of other organism (GO:0098543)4.01650668
33synaptic vesicle exocytosis (GO:0016079)3.96036122
34negative thymic T cell selection (GO:0045060)3.94288950
35regulation of histone H3-K27 methylation (GO:0061085)3.92192246
36neutrophil activation involved in immune response (GO:0002283)3.89045042
37macrophage activation involved in immune response (GO:0002281)3.88596638
38negative regulation of T cell mediated immunity (GO:0002710)3.88196607
39synaptic vesicle endocytosis (GO:0048488)3.86372099
40detection of molecule of bacterial origin (GO:0032490)3.85120942
41regulation of short-term neuronal synaptic plasticity (GO:0048172)3.84156473
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.81021971
43negative regulation of interleukin-12 production (GO:0032695)3.79791905
44leukocyte aggregation (GO:0070486)3.78181995
45regulation of synaptic vesicle exocytosis (GO:2000300)3.77469933
46detection of bacterium (GO:0016045)3.73910678
47cellular extravasation (GO:0045123)3.69842247
48photoreceptor cell maintenance (GO:0045494)3.69442515
49regulation of clathrin-mediated endocytosis (GO:2000369)3.69046959
50regulation of transforming growth factor beta2 production (GO:0032909)3.68285441
51regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.65558408
52detection of external biotic stimulus (GO:0098581)3.64472013
53positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.62740373
54protein-chromophore linkage (GO:0018298)3.62421741
55regulation of synaptic vesicle transport (GO:1902803)3.58538341
56negative regulation of leukocyte mediated immunity (GO:0002704)3.58337008
57positive regulation of vesicle fusion (GO:0031340)3.57347971
58response to pheromone (GO:0019236)3.55633812
59response to peptidoglycan (GO:0032494)3.54189497
60positive T cell selection (GO:0043368)3.46082623
61neutrophil activation (GO:0042119)3.44699870
62positive regulation of synapse maturation (GO:0090129)3.41803671
63cellular sodium ion homeostasis (GO:0006883)3.40092178
64positive thymic T cell selection (GO:0045059)3.39746983
65positive regulation of gamma-delta T cell activation (GO:0046645)3.37254728
66response to muramyl dipeptide (GO:0032495)3.32487184
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.31749622
68T cell migration (GO:0072678)3.29424151
69granulocyte activation (GO:0036230)3.28624854
70regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.27468961
71regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.27468961
72V(D)J recombination (GO:0033151)3.26900704
73positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.26295923
74neutrophil mediated immunity (GO:0002446)3.24566790
75vocalization behavior (GO:0071625)3.23380794
76tolerance induction (GO:0002507)3.21584773
77T cell selection (GO:0045058)3.21558322
78regulation of ARF protein signal transduction (GO:0032012)3.21331612
79regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.20573315
80myeloid cell activation involved in immune response (GO:0002275)3.20373977
81potassium ion homeostasis (GO:0055075)3.19023829
82regulation of T cell tolerance induction (GO:0002664)3.18923510
83germinal center formation (GO:0002467)3.16809171
84negative regulation of cytosolic calcium ion concentration (GO:0051481)3.16631100
85positive regulation of granulocyte differentiation (GO:0030854)3.16038588
86regulation of meiosis (GO:0040020)3.15363897
87detection of biotic stimulus (GO:0009595)3.14511888
88cellular response to type I interferon (GO:0071357)3.12332728
89type I interferon signaling pathway (GO:0060337)3.12332728
90regulation of interferon-beta biosynthetic process (GO:0045357)3.09947799
91response to type I interferon (GO:0034340)3.08952235
92positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.08369683
93microglial cell activation (GO:0001774)3.07532744
94regulation of tolerance induction (GO:0002643)3.06731766
95positive regulation of sodium ion transmembrane transport (GO:1902307)3.05495931
96regulation of T cell mediated cytotoxicity (GO:0001914)3.05071311
97macrophage activation (GO:0042116)3.03273121
98negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.03189220
99negative regulation of circadian rhythm (GO:0042754)3.01157698
100synaptic vesicle maturation (GO:0016188)3.00573754
101regulation of alpha-beta T cell proliferation (GO:0046640)3.00278798
102antigen processing and presentation via MHC class Ib (GO:0002475)2.99980110
103activated T cell proliferation (GO:0050798)2.99473128
104glutamate receptor signaling pathway (GO:0007215)2.97483881
105leukocyte degranulation (GO:0043299)2.96812774
106innervation (GO:0060384)2.96412257
107thymic T cell selection (GO:0045061)2.95915933
108glutamate secretion (GO:0014047)2.95326747
109respiratory burst (GO:0045730)2.95103152
110myeloid leukocyte mediated immunity (GO:0002444)2.94921047
111negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.94554137
112behavioral response to ethanol (GO:0048149)2.93406240
113response to histamine (GO:0034776)2.92041487
114regulation of meiosis I (GO:0060631)2.91574621
115negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.91533928
116negative regulation of meiosis (GO:0045835)2.90874334
117long term synaptic depression (GO:0060292)2.90593188
118long-term synaptic potentiation (GO:0060291)2.90315660
119mast cell activation (GO:0045576)2.90041476
120response to host immune response (GO:0052572)2.89416373
121response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.89416373
122positive regulation of tolerance induction (GO:0002645)2.89238718
123striatum development (GO:0021756)2.88744189
124interferon-gamma-mediated signaling pathway (GO:0060333)2.87064962
125cerebellar Purkinje cell differentiation (GO:0021702)2.85098389
126regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.84440085
127regulation of natural killer cell mediated immunity (GO:0002715)2.84440085
128positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.83740299
129immunoglobulin mediated immune response (GO:0016064)2.81623149
130negative regulation of type 2 immune response (GO:0002829)2.81005990
131interferon-gamma production (GO:0032609)2.80040820
132mitotic sister chromatid cohesion (GO:0007064)2.79819907
133production of molecular mediator involved in inflammatory response (GO:0002532)2.79786684
134positive regulation of T cell mediated cytotoxicity (GO:0001916)2.78698757
135regulation of mast cell degranulation (GO:0043304)2.77542352
136negative regulation of glycoprotein biosynthetic process (GO:0010561)2.77031954
137positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.76461583
138negative regulation of adaptive immune response (GO:0002820)2.75703881
139response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.75606310
140response to host (GO:0075136)2.75606310
141response to host defenses (GO:0052200)2.75606310
142regulation of mast cell activation (GO:0033003)2.74611451
143visual perception (GO:0007601)2.73554888
144regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.72736287
145regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.72196816
146regulation of gamma-delta T cell differentiation (GO:0045586)2.72177078
147sensory perception of light stimulus (GO:0050953)2.71883096
148negative regulation of cell killing (GO:0031342)2.71467247
149negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.71467247
150negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.69730329
151regulation of B cell differentiation (GO:0045577)2.69592097
152regulation of vesicle fusion (GO:0031338)2.69461145
153positive regulation of cellular amide metabolic process (GO:0034250)2.68950158
154dendritic cell migration (GO:0036336)2.68705819
155B cell receptor signaling pathway (GO:0050853)2.67391392
156negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.67346946
157negative regulation of T-helper cell differentiation (GO:0045623)2.67346946
158regulation of mast cell activation involved in immune response (GO:0033006)2.66511894
159lipopolysaccharide-mediated signaling pathway (GO:0031663)2.66339862
160positive regulation of mast cell activation (GO:0033005)2.66300944
161myeloid leukocyte activation (GO:0002274)2.65934842
162negative regulation of thymocyte apoptotic process (GO:0070244)2.64825474
163regulation of Rap GTPase activity (GO:0032317)2.63445803
164regulation of myeloid leukocyte mediated immunity (GO:0002886)2.63285831
165negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.62701341
166positive regulation of neurotransmitter secretion (GO:0001956)2.62180363
167protein localization to synapse (GO:0035418)2.61881920
168regulation of gamma-delta T cell activation (GO:0046643)2.61605703
169regulation of RIG-I signaling pathway (GO:0039535)2.60214514
170positive regulation of histone deacetylation (GO:0031065)2.59256929
171locomotory exploration behavior (GO:0035641)2.58458791
172regulation of corticosteroid hormone secretion (GO:2000846)2.57392539
173regulation of glucocorticoid metabolic process (GO:0031943)2.56971068
174positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.56612924
175regulation of glucocorticoid secretion (GO:2000849)2.52524385
176regulation of retinoic acid receptor signaling pathway (GO:0048385)2.52054980
177cellular response to light stimulus (GO:0071482)2.51909027
178neurotransmitter-gated ion channel clustering (GO:0072578)2.51207851
179retina development in camera-type eye (GO:0060041)2.49282889
180detection of light stimulus (GO:0009583)2.48369612
181regulation of neurotransmitter secretion (GO:0046928)2.48000224
182regulation of calcium ion-dependent exocytosis (GO:0017158)2.46449659
183histone H3-K4 methylation (GO:0051568)2.45631270
184neurotransmitter secretion (GO:0007269)2.44117597
185positive regulation of Rap GTPase activity (GO:0032854)2.43377072
186oocyte maturation (GO:0001556)2.42972100
187positive regulation of neurotransmitter transport (GO:0051590)2.42437296
188histone H2A monoubiquitination (GO:0035518)2.41016462
189neuron-neuron synaptic transmission (GO:0007270)2.39968400
190positive regulation of membrane potential (GO:0045838)2.39770124
191cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.38761036
192detection of visible light (GO:0009584)2.37291072
193positive regulation of fibroblast migration (GO:0010763)2.36929505
194mitotic chromosome condensation (GO:0007076)2.36245740

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.97921690
2SMAD_19615063_ChIP-ChIP_OVARY_Human4.36227905
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.11346131
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.84677213
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.50541075
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.35007803
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.18781385
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.16944947
9EZH2_22144423_ChIP-Seq_EOC_Human3.15018471
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.12431346
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.03399976
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.98405281
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.92874037
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.89519289
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.80360895
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.80326311
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.76615731
18* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.72031927
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45543262
20MYC_22102868_ChIP-Seq_BL_Human2.41918174
21* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.35025167
22MYB_26560356_Chip-Seq_TH2_Human2.34386242
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.33263218
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.21874920
25RUNX_20019798_ChIP-Seq_JUKART_Human2.17537102
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13310164
27* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.05789769
28AR_21572438_ChIP-Seq_LNCaP_Human2.05457518
29STAT4_19710469_ChIP-ChIP_TH1__Mouse2.04065518
30RARB_27405468_Chip-Seq_BRAIN_Mouse2.03755299
31SCL_19346495_ChIP-Seq_HPC-7_Human1.97750802
32* SPI1_23127762_ChIP-Seq_K562_Human1.97425249
33GBX2_23144817_ChIP-Seq_PC3_Human1.96883316
34DROSHA_22980978_ChIP-Seq_HELA_Human1.95840703
35VDR_24787735_ChIP-Seq_THP-1_Human1.91965555
36SPI1_23547873_ChIP-Seq_NB4_Human1.89839991
37MAF_26560356_Chip-Seq_TH1_Human1.88382029
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87116657
39MYB_26560356_Chip-Seq_TH1_Human1.85774444
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83424223
41IGF1R_20145208_ChIP-Seq_DFB_Human1.80043517
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.77950591
43VDR_24763502_ChIP-Seq_THP-1_Human1.77899931
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.74770951
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73702572
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.71681748
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69801571
48* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.66196491
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65130574
50* REST_21632747_ChIP-Seq_MESCs_Mouse1.63378463
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.61569132
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57839325
53* STAT3_23295773_ChIP-Seq_U87_Human1.56768378
54SMAD4_21799915_ChIP-Seq_A2780_Human1.56762874
55E2F7_22180533_ChIP-Seq_HELA_Human1.53186492
56FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.50390894
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47997469
58P53_22127205_ChIP-Seq_FIBROBLAST_Human1.46329859
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45264195
60NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.43974062
61GATA3_26560356_Chip-Seq_TH2_Human1.43203251
62PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42522155
63FUS_26573619_Chip-Seq_HEK293_Human1.42118554
64PU_27001747_Chip-Seq_BMDM_Mouse1.38615844
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38170837
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.36673276
67* AR_25329375_ChIP-Seq_VCAP_Human1.35789383
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35701797
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33775820
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.32589471
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.32528293
72MAF_26560356_Chip-Seq_TH2_Human1.30871307
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30246695
74DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30216655
75VDR_21846776_ChIP-Seq_THP-1_Human1.30176693
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29999929
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29865435
78BCAT_22108803_ChIP-Seq_LS180_Human1.28544848
79TP53_16413492_ChIP-PET_HCT116_Human1.28249237
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.25907687
81* REST_18959480_ChIP-ChIP_MESCs_Mouse1.25117249
82YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23445690
83AR_19668381_ChIP-Seq_PC3_Human1.23424907
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23424177
85* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23406946
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22649371
87LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21474372
88* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20123311
89LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19485042
90ESR1_20079471_ChIP-ChIP_T-47D_Human1.18782181
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16966598
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.16921535
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16782543
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.16246936
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16020906
96CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15601765
97TCF4_23295773_ChIP-Seq_U87_Human1.13809165
98LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12557604
99KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09902479
100* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09653580
101* PIAS1_25552417_ChIP-Seq_VCAP_Human1.09278144
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09185943
103TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09044377
104TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08930603
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.07125237
106GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04797249
107ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04769954
108TCF7_22412390_ChIP-Seq_EML_Mouse1.04504226
109FOXO3_23340844_ChIP-Seq_DLD1_Human1.03332422
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03263978
111P300_19829295_ChIP-Seq_ESCs_Human1.03115379
112CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02584965
113CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02357807
114* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02238432
115TAF15_26573619_Chip-Seq_HEK293_Human1.02148489
116SMAD3_21741376_ChIP-Seq_HESCs_Human1.01982712
117WDR5_24793694_ChIP-Seq_LNCAP_Human1.01791206
118FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01362928
119GATA3_27048872_Chip-Seq_THYMUS_Human1.00624078
120CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97360885
121GATA1_19941826_ChIP-Seq_K562_Human0.96563199
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95219143
123GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94635328
124STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94224640
125* TBL1_22424771_ChIP-Seq_293T_Human0.93147808
126CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92707494
127GATA1_22025678_ChIP-Seq_K562_Human0.92280389
128FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92218259
129KDM2B_26808549_Chip-Seq_K562_Human0.91982599
130GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91574838
131UTX_26944678_Chip-Seq_JUKART_Human0.90816146
132CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90245559
133PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90056093
134ELK4_26923725_Chip-Seq_MESODERM_Mouse0.89823847
135KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89088945
136SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88810579
137* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.88106222
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87747299
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87747299
140* KDM2B_26808549_Chip-Seq_JURKAT_Human0.87678523
141SMRT_27268052_Chip-Seq_Bcells_Human0.86539374
142CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.85504035
143GATA2_19941826_ChIP-Seq_K562_Human0.84673826
144CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84204931
145PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83506024
146* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.83210068
147* KDM2B_26808549_Chip-Seq_DND41_Human0.83144646
148WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82519834
149ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.82316225
150NANOG_18555785_Chip-Seq_ESCs_Mouse0.82057405
151RNF2_27304074_Chip-Seq_ESCs_Mouse0.81422509
152IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.79271750
153KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.79192321
154TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.79176662
155KDM2B_26808549_Chip-Seq_REH_Human0.78866391
156GATA1_19941827_ChIP-Seq_MEL86_Mouse0.77476296
157CBP_20019798_ChIP-Seq_JUKART_Human0.77248438
158IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.77248438
159* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.76465666
160CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75969039
161SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.75403912
162SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.75403912
163BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73290188
164TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71618220
165* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71362476
166JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71266795
167ELK3_25401928_ChIP-Seq_HUVEC_Human0.70406487
168LXR_22158963_ChIP-Seq_LIVER_Mouse0.70244518
169THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.70176090
170CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68996427
171* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.67725154
172ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.66916412
173RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66513152
174SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.66326553
175NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.65547744
176CDX2_19796622_ChIP-Seq_MESCs_Mouse0.64620765
177GATA1_22383799_ChIP-Seq_G1ME_Mouse0.63811400

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog5.36678106
2MP0003724_increased_susceptibility_to4.12589714
3MP0006072_abnormal_retinal_apoptosis4.06611713
4MP0003436_decreased_susceptibility_to3.72573643
5MP0004859_abnormal_synaptic_plasticity3.51816945
6MP0003787_abnormal_imprinting3.44839569
7MP0001835_abnormal_antigen_presentation3.24382859
8MP0003303_peritoneal_inflammation3.07908997
9MP0005253_abnormal_eye_physiology2.81441423
10MP0005000_abnormal_immune_tolerance2.78371138
11MP0002419_abnormal_innate_immunity2.73870519
12MP0002090_abnormal_vision2.63578912
13MP0009785_altered_susceptibility_to2.62081531
14MP0006082_CNS_inflammation2.57986625
15MP0002653_abnormal_ependyma_morphology2.55874175
16MP0005025_abnormal_response_to2.52948204
17MP0003191_abnormal_cellular_cholesterol2.48145690
18MP0003300_gastrointestinal_ulcer2.42685984
19MP0003011_delayed_dark_adaptation2.40405348
20MP0000569_abnormal_digit_pigmentation2.35985456
21* MP0001502_abnormal_circadian_rhythm2.33540977
22* MP0001819_abnormal_immune_cell2.29760324
23MP0003635_abnormal_synaptic_transmissio2.28711512
24MP0010234_abnormal_vibrissa_follicle2.26910724
25MP0002638_abnormal_pupillary_reflex2.22923111
26MP0002148_abnormal_hypersensitivity_rea2.21421264
27MP0010386_abnormal_urinary_bladder2.18284181
28MP0003646_muscle_fatigue2.16044286
29MP0008260_abnormal_autophagy2.14582866
30MP0006292_abnormal_olfactory_placode2.12381835
31MP0008877_abnormal_DNA_methylation2.10950750
32MP0002405_respiratory_system_inflammati1.97025885
33MP0004145_abnormal_muscle_electrophysio1.96852313
34MP0005195_abnormal_posterior_eye1.96807201
35MP0000013_abnormal_adipose_tissue1.96114613
36MP0003879_abnormal_hair_cell1.93057811
37MP0003172_abnormal_lysosome_physiology1.89248447
38MP0002063_abnormal_learning/memory/cond1.86466223
39MP0003880_abnormal_central_pattern1.82348009
40MP0003045_fibrosis1.81353317
41MP0004381_abnormal_hair_follicle1.79997506
42* MP0001533_abnormal_skeleton_physiology1.79681906
43MP0005464_abnormal_platelet_physiology1.73193687
44MP0001845_abnormal_inflammatory_respons1.66099178
45MP0000465_gastrointestinal_hemorrhage1.64607625
46MP0003763_abnormal_thymus_physiology1.60483781
47MP0010155_abnormal_intestine_physiology1.59607212
48MP0003828_pulmonary_edema1.58726464
49MP0009333_abnormal_splenocyte_physiolog1.57491865
50MP0003866_abnormal_defecation1.55191809
51MP0009745_abnormal_behavioral_response1.55096535
52MP0001984_abnormal_olfaction1.51334717
53MP0008961_abnormal_basal_metabolism1.48959013
54MP0005451_abnormal_body_composition1.47563084
55MP0003183_abnormal_peptide_metabolism1.46946000
56MP0009780_abnormal_chondrocyte_physiolo1.44177032
57MP0010094_abnormal_chromosome_stability1.42578319
58* MP0001851_eye_inflammation1.40239594
59MP0003690_abnormal_glial_cell1.38581139
60* MP0002998_abnormal_bone_remodeling1.37293072
61MP0002229_neurodegeneration1.36759037
62MP0004270_analgesia1.36496415
63MP0009764_decreased_sensitivity_to1.36239227
64MP0002572_abnormal_emotion/affect_behav1.34829378
65MP0003075_altered_response_to1.34342457
66MP0004264_abnormal_extraembryonic_tissu1.34189267
67* MP0002429_abnormal_blood_cell1.31604550
68MP0004883_abnormal_blood_vessel1.30783490
69MP0000604_amyloidosis1.28877908
70* MP0008469_abnormal_protein_level1.28124917
71MP0004510_myositis1.27477497
72MP0000858_altered_metastatic_potential1.26554779
73MP0009840_abnormal_foam_cell1.24473084
74MP0002064_seizures1.24472480
75MP0000703_abnormal_thymus_morphology1.23727000
76* MP0001800_abnormal_humoral_immune1.22954814
77MP0001968_abnormal_touch/_nociception1.21532023
78MP0000015_abnormal_ear_pigmentation1.20874746
79MP0005310_abnormal_salivary_gland1.20213526
80MP0005646_abnormal_pituitary_gland1.18855471
81MP0002909_abnormal_adrenal_gland1.16677337
82MP0005058_abnormal_lysosome_morphology1.15355995
83MP0010368_abnormal_lymphatic_system1.14770526
84MP0002736_abnormal_nociception_after1.14672774
85MP0004808_abnormal_hematopoietic_stem1.12662284
86MP0000685_abnormal_immune_system1.11364849
87* MP0004233_abnormal_muscle_weight1.09494009
88MP0005391_vision/eye_phenotype1.09221260
89* MP0005164_abnormal_response_to1.06813954
90MP0009278_abnormal_bone_marrow1.06555856
91MP0005166_decreased_susceptibility_to1.06541569
92MP0002396_abnormal_hematopoietic_system1.06303368
93* MP0002398_abnormal_bone_marrow1.04573590
94* MP0002067_abnormal_sensory_capabilities1.03197190
95MP0008569_lethality_at_weaning1.03109112
96* MP0003699_abnormal_female_reproductive1.02567606
97MP0001919_abnormal_reproductive_system1.02051958
98MP0004947_skin_inflammation1.01219048
99MP0005075_abnormal_melanosome_morpholog1.01127869
100MP0002734_abnormal_mechanical_nocicepti1.00901802
101MP0000920_abnormal_myelination1.00490531
102MP0003448_altered_tumor_morphology1.00106343
103MP0005174_abnormal_tail_pigmentation0.99288321
104MP0001853_heart_inflammation0.99112731
105MP0009763_increased_sensitivity_to0.99038473
106MP0003656_abnormal_erythrocyte_physiolo0.98142997
107MP0001944_abnormal_pancreas_morphology0.98078660
108MP0005671_abnormal_response_to0.97416746
109MP0002006_tumorigenesis0.96984441
110MP0002184_abnormal_innervation0.96604427
111MP0002272_abnormal_nervous_system0.96498152
112MP0005621_abnormal_cell_physiology0.95139340
113MP0008007_abnormal_cellular_replicative0.95057119
114MP0001545_abnormal_hematopoietic_system0.94371816
115MP0005397_hematopoietic_system_phenotyp0.94371816
116MP0005499_abnormal_olfactory_system0.94286986
117MP0005394_taste/olfaction_phenotype0.94286986
118MP0003718_maternal_effect0.93327695
119MP0001324_abnormal_eye_pigmentation0.92319335
120MP0002277_abnormal_respiratory_mucosa0.90977287
121MP0002102_abnormal_ear_morphology0.90685157
122MP0003091_abnormal_cell_migration0.90634002
123MP0001440_abnormal_grooming_behavior0.88834699
124MP0002332_abnormal_exercise_endurance0.88376645
125MP0002019_abnormal_tumor_incidence0.87505310
126MP0003693_abnormal_embryo_hatching0.86830289
127MP0000003_abnormal_adipose_tissue0.86520039
128MP0006054_spinal_hemorrhage0.84839412
129MP0000343_altered_response_to0.84559990
130MP0003950_abnormal_plasma_membrane0.84210949
131MP0005220_abnormal_exocrine_pancreas0.83331017
132MP0002928_abnormal_bile_duct0.83275293
133MP0001486_abnormal_startle_reflex0.82304710
134MP0001958_emphysema0.81952615
135MP0001346_abnormal_lacrimal_gland0.81442985
136MP0002882_abnormal_neuron_morphology0.81357947
137MP0000249_abnormal_blood_vessel0.81301964
138MP0008004_abnormal_stomach_pH0.80531747
139* MP0000689_abnormal_spleen_morphology0.80498544
140* MP0001119_abnormal_female_reproductive0.80325377
141MP0010307_abnormal_tumor_latency0.78738345
142MP0000631_abnormal_neuroendocrine_gland0.78340669
143MP0002752_abnormal_somatic_nervous0.77559993
144MP0000371_diluted_coat_color0.77077208
145MP0005387_immune_system_phenotype0.77060122
146MP0001790_abnormal_immune_system0.77060122
147* MP0001501_abnormal_sleep_pattern0.76982888
148MP0001177_atelectasis0.76916713
149* MP0002723_abnormal_immune_serum0.76700304
150MP0003329_amyloid_beta_deposits0.76131548
151* MP0002722_abnormal_immune_system0.76064334
152MP0004130_abnormal_muscle_cell0.75278711
153MP0008874_decreased_physiological_sensi0.75247033
154MP0004782_abnormal_surfactant_physiolog0.75169900
155* MP0002452_abnormal_antigen_presenting0.75066855
156MP0005187_abnormal_penis_morphology0.73653794
157MP0005076_abnormal_cell_differentiation0.73618568
158MP0005395_other_phenotype0.73113946
159MP0003453_abnormal_keratinocyte_physiol0.73096515
160MP0002166_altered_tumor_susceptibility0.72619014
161MP0001873_stomach_inflammation0.72319497
162MP0009765_abnormal_xenobiotic_induced0.72206150
163MP0002877_abnormal_melanocyte_morpholog0.71245315
164* MP0002420_abnormal_adaptive_immunity0.71035104
165* MP0000716_abnormal_immune_system0.70679843
166MP0003252_abnormal_bile_duct0.70323847
167MP0002933_joint_inflammation0.63650176
168MP0005388_respiratory_system_phenotype0.62874614
169MP0002133_abnormal_respiratory_system0.62874614
170MP0003221_abnormal_cardiomyocyte_apopto0.62035216
171MP0002138_abnormal_hepatobiliary_system0.61493326
172MP0003566_abnormal_cell_adhesion0.60867815
173MP0004484_altered_response_of0.59144478

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)9.32780583
2Abnormal rod and cone electroretinograms (HP:0008323)6.34464497
3Bony spicule pigmentary retinopathy (HP:0007737)6.02259331
4Eczematoid dermatitis (HP:0000976)5.69563004
5Abnormality of macular pigmentation (HP:0008002)5.55098718
6Central scotoma (HP:0000603)5.26161307
7Absent rod-and cone-mediated responses on ERG (HP:0007688)5.07808627
8Myositis (HP:0100614)4.93320805
9Retrobulbar optic neuritis (HP:0100654)4.88244431
10Optic neuritis (HP:0100653)4.88244431
11Orchitis (HP:0100796)4.86663169
12Recurrent bacterial skin infections (HP:0005406)4.81660685
13Recurrent abscess formation (HP:0002722)4.61570047
14Chorioretinal atrophy (HP:0000533)4.34733704
15Abnormality of macrophages (HP:0004311)4.26226575
16Stomatitis (HP:0010280)4.23600238
17Scotoma (HP:0000575)4.19832670
18B lymphocytopenia (HP:0010976)4.08801632
19Abnormality of B cell number (HP:0010975)4.08801632
20Severe visual impairment (HP:0001141)3.92701880
21Elevated erythrocyte sedimentation rate (HP:0003565)3.80805870
22Recurrent gram-negative bacterial infections (HP:0005420)3.73555256
23Recurrent fungal infections (HP:0002841)3.72457288
24Thyroiditis (HP:0100646)3.69803785
25Posterior subcapsular cataract (HP:0007787)3.64544500
26Agammaglobulinemia (HP:0004432)3.56219469
27Gastrointestinal infarctions (HP:0005244)3.53170167
28Keratoconjunctivitis sicca (HP:0001097)3.52036794
29Febrile seizures (HP:0002373)3.45666850
30Pendular nystagmus (HP:0012043)3.44949864
31Pigmentary retinal degeneration (HP:0001146)3.44584319
32Focal motor seizures (HP:0011153)3.42382633
33Epileptic encephalopathy (HP:0200134)3.40639854
34Recurrent skin infections (HP:0001581)3.36451170
35Mediastinal lymphadenopathy (HP:0100721)3.34305468
36Abolished electroretinogram (ERG) (HP:0000550)3.30759094
37Keratoconjunctivitis (HP:0001096)3.24284124
38Papilledema (HP:0001085)3.21518940
39Panhypogammaglobulinemia (HP:0003139)3.17225732
40Chronic mucocutaneous candidiasis (HP:0002728)3.16517341
41Recurrent cutaneous fungal infections (HP:0011370)3.16517341
42Attenuation of retinal blood vessels (HP:0007843)3.15728384
43Type II diabetes mellitus (HP:0005978)3.13334668
44Vasculitis (HP:0002633)3.12488965
45Pulmonary infiltrates (HP:0002113)3.09553083
46Decreased central vision (HP:0007663)3.07877675
47Gingivitis (HP:0000230)3.00483924
48Encephalitis (HP:0002383)2.94164611
49Spontaneous hematomas (HP:0007420)2.93621050
50Gingival bleeding (HP:0000225)2.92062264
51Abnormality of the fingertips (HP:0001211)2.90988662
52Photophobia (HP:0000613)2.89746106
53Pustule (HP:0200039)2.86357865
54Chest pain (HP:0100749)2.83314992
55Hemoptysis (HP:0002105)2.82284394
56Leukocytosis (HP:0001974)2.81214072
57Hypoplasia of the fovea (HP:0007750)2.81201788
58Aplasia/Hypoplasia of the fovea (HP:0008060)2.81201788
59T lymphocytopenia (HP:0005403)2.79268728
60Obstructive lung disease (HP:0006536)2.77191000
61Chronic obstructive pulmonary disease (HP:0006510)2.77191000
62Arterial thrombosis (HP:0004420)2.75935082
63Increased IgE level (HP:0003212)2.75931774
64Slow saccadic eye movements (HP:0000514)2.74165493
65Severe combined immunodeficiency (HP:0004430)2.71803789
66Arterial tortuosity (HP:0005116)2.68008605
67Visual hallucinations (HP:0002367)2.67793762
68Abnormality of eosinophils (HP:0001879)2.65221226
69Volvulus (HP:0002580)2.62975742
70Urticaria (HP:0001025)2.60105084
71Keratoconus (HP:0000563)2.59658710
72Increased corneal curvature (HP:0100692)2.59658710
73Amyloidosis (HP:0011034)2.58817177
74Abnormality of T cell number (HP:0011839)2.56922955
75Pulmonary embolism (HP:0002204)2.56829371
76Abnormality of the fovea (HP:0000493)2.56235377
77Abnormality of liposaccharide metabolism (HP:0010968)2.54400125
78Abnormality of glycosphingolipid metabolism (HP:0004343)2.54400125
79Abnormality of glycolipid metabolism (HP:0010969)2.54400125
80Hypoplasia of the thymus (HP:0000778)2.51310739
81Gangrene (HP:0100758)2.50476888
82Subacute progressive viral hepatitis (HP:0006572)2.49335118
83Loss of speech (HP:0002371)2.47619046
84Verrucae (HP:0200043)2.46129298
85Papilloma (HP:0012740)2.46129298
86Autoimmune hemolytic anemia (HP:0001890)2.46019500
87Constricted visual fields (HP:0001133)2.45531271
88Macular degeneration (HP:0000608)2.45195627
89Enlarged penis (HP:0000040)2.43491935
90Eosinophilia (HP:0001880)2.43102150
91Epistaxis (HP:0000421)2.38433319
92Absence seizures (HP:0002121)2.37860163
93Vascular tortuosity (HP:0004948)2.35621284
94Episodic fever (HP:0001954)2.34085825
95Combined immunodeficiency (HP:0005387)2.34025202
96Granulocytopenia (HP:0001913)2.33639958
97Inflammation of the large intestine (HP:0002037)2.33453035
98Spondylolisthesis (HP:0003302)2.30448021
99Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.29755344
100Chronic diarrhea (HP:0002028)2.28718959
101Oligodactyly (hands) (HP:0001180)2.28582162
102Retinitis pigmentosa (HP:0000510)2.28525424
103Recurrent viral infections (HP:0004429)2.27195030
104Joint swelling (HP:0001386)2.24161853
105Interstitial pulmonary disease (HP:0006530)2.21429536
106Focal seizures (HP:0007359)2.20595721
107Gastrointestinal inflammation (HP:0004386)2.18372549
108Anorexia (HP:0002039)2.17347221
109Prolonged bleeding time (HP:0003010)2.17259091
110Hypochromic microcytic anemia (HP:0004840)2.15756486
111Dysostosis multiplex (HP:0000943)2.11455820
112Fatigue (HP:0012378)2.09291630
113Peritonitis (HP:0002586)2.09256239
114Periodontitis (HP:0000704)2.06828759
115Glomerulopathy (HP:0100820)2.05464808
116Hemiplegia (HP:0002301)2.05437946
117Cone-rod dystrophy (HP:0000548)2.05254120
118Dysmetric saccades (HP:0000641)2.04700701
119Molar tooth sign on MRI (HP:0002419)2.04661871
120Abnormality of midbrain morphology (HP:0002418)2.04661871
121Increased CSF protein (HP:0002922)2.04332524
122Genetic anticipation (HP:0003743)2.03912331
123Congenital sensorineural hearing impairment (HP:0008527)2.02185846
124Abnormal delayed hypersensitivity skin test (HP:0002963)2.01970978
125Increased cerebral lipofuscin (HP:0011813)2.00551387
126Osteomyelitis (HP:0002754)1.97128163
127Cellulitis (HP:0100658)1.96388717
128Dyschromatopsia (HP:0007641)1.96224043
129Choroideremia (HP:0001139)1.95728674
130Abnormality of the pleura (HP:0002103)1.95070713
131Lymphopenia (HP:0001888)1.94547525
132Dialeptic seizures (HP:0011146)1.94042505
133Increased IgM level (HP:0003496)1.93770064
134Keratitis (HP:0000491)1.93354531
135Abnormality of the endocardium (HP:0004306)1.93159869
136Hypochromic anemia (HP:0001931)1.92169049
137Premature loss of primary teeth (HP:0006323)1.91751609
138Atonic seizures (HP:0010819)1.91312350
139Ocular albinism (HP:0001107)1.91171141
140Aplasia/Hypoplasia of the macula (HP:0008059)1.89774758
141Sepsis (HP:0100806)1.89174502
142Vertigo (HP:0002321)1.88917286
143Impaired smooth pursuit (HP:0007772)1.81919128
144Autoimmune thrombocytopenia (HP:0001973)1.81407409
145Abnormality of cells of the lymphoid lineage (HP:0012140)1.81089498
146Petechiae (HP:0000967)1.80301372
147Diplopia (HP:0000651)1.80086380
148Abnormality of binocular vision (HP:0011514)1.80086380
149Hypergammaglobulinemia (HP:0010702)1.79946673
150Abnormality of T cell physiology (HP:0011840)1.79861851
151Truncal obesity (HP:0001956)1.79492897
152Acute hepatic failure (HP:0006554)1.79335987
153Abnormality of the pericardium (HP:0001697)1.79194359
154Cheilitis (HP:0100825)1.77995923
155Pancreatic fibrosis (HP:0100732)1.77329483
156Progressive cerebellar ataxia (HP:0002073)1.76882249
157Abnormality of the intervertebral disk (HP:0005108)1.74763020
158Recurrent bronchitis (HP:0002837)1.73577745
159Urinary bladder sphincter dysfunction (HP:0002839)1.72137567
160Acute lymphatic leukemia (HP:0006721)1.70994994
161Aplasia/Hypoplasia affecting the retina (HP:0008061)1.70112497
162Hypoproteinemia (HP:0003075)1.69406304
163Aplasia/Hypoplasia of the tongue (HP:0010295)1.68104264
164Long eyelashes (HP:0000527)1.67926758
165Chorioretinal coloboma (HP:0000567)1.65918524
166Cystic liver disease (HP:0006706)1.65787173
167Abnormality of ocular smooth pursuit (HP:0000617)1.63837101
168Truncal ataxia (HP:0002078)1.63494965
169Abnormality of T cells (HP:0002843)1.61619062
170Papillary thyroid carcinoma (HP:0002895)1.59654549
171Vertebral arch anomaly (HP:0008438)1.58089552
172Albinism (HP:0001022)1.57439903
173Neoplasm of the heart (HP:0100544)1.57232525
174Progressive visual loss (HP:0000529)1.56602443
175True hermaphroditism (HP:0010459)1.55695144
176Generalized tonic-clonic seizures (HP:0002069)1.55672888
177Meningitis (HP:0001287)1.54460529
178Mutism (HP:0002300)1.54152810
179Male infertility (HP:0003251)1.54035437
180IgG deficiency (HP:0004315)1.53993887
181Emphysema (HP:0002097)1.53865855
182Widely spaced teeth (HP:0000687)1.53697320
183Subcapsular cataract (HP:0000523)1.52573501
184Facial hemangioma (HP:0000329)1.51895764
185Colitis (HP:0002583)1.51576911
186Pancreatic cysts (HP:0001737)1.51415847
187Oligodactyly (HP:0012165)1.49346228

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K134.07112399
2EEF2K3.59384572
3MAP3K93.43701277
4TAOK33.21990368
5KSR23.08483314
6TYK22.60588239
7PRPF4B2.56482646
8IRAK42.49894310
9MAP3K42.45714208
10MAP3K62.44545954
11CSK2.42629145
12MOS2.38731118
13MAP3K102.34511899
14MAP3K142.30312454
15MUSK2.26843581
16BMPR22.24477831
17EPHA42.22260347
18BLK2.16373776
19RAF12.15927458
20KSR12.13982177
21PAK62.06842282
22EPHB12.03355163
23PRKD32.02459791
24LATS11.93466731
25MAPKAPK31.93140343
26MAP2K31.84026166
27IKBKE1.78924043
28CDK91.67574686
29TAOK11.56323053
30HCK1.54223622
31RIPK41.54014731
32ARAF1.51995104
33ERN11.50279005
34BRAF1.45501906
35BTK1.38751283
36STK381.37590287
37JAK21.36905089
38NTRK31.35958787
39CDK31.35924968
40TBK11.35488560
41MARK31.33874693
42FGR1.29886302
43LCK1.27462791
44TNK21.27257575
45CDK81.26764760
46MAP3K31.26163865
47ITK1.25267761
48SIK21.24815488
49CAMKK21.22525652
50PRKD21.20482979
51PRKCH1.12474709
52LYN1.10553865
53TGFBR21.07007040
54NEK11.03018490
55MAP4K11.01455864
56GRK61.01399924
57PIK3CG1.01297368
58MATK1.00990092
59STK38L1.00303597
60FGFR30.98914925
61ACVR1B0.98203270
62NLK0.97972208
63MAPK70.97754551
64YES10.96981746
65NEK20.96547610
66IRAK10.95846392
67FRK0.95623059
68KIT0.94346035
69MAP2K70.94001248
70PKN20.93590074
71IKBKB0.91249333
72MAPK130.91242155
73CAMKK10.90307409
74IRAK20.88285188
75LATS20.86996675
76TTK0.85785694
77EPHA30.84118308
78MAP3K70.82694125
79RPS6KB20.82386901
80SGK20.82090826
81FGFR40.81953969
82ERBB40.81603788
83DYRK1A0.81043518
84MINK10.80330313
85MAP3K20.79637793
86MAP2K40.78803491
87RET0.78370385
88FES0.78264441
89MELK0.76200047
90CSF1R0.74338024
91TEC0.74113820
92RPS6KA40.73596145
93DAPK10.73420134
94SGK30.73383741
95PINK10.72201226
96RIPK10.71267451
97CDC42BPA0.70053652
98HIPK20.69081928
99MAPKAPK50.68394202
100CDC70.68072102
101PDPK10.67366521
102GRK70.67057340
103PRKCQ0.66577295
104MAP3K10.66399412
105FYN0.65818107
106CCNB10.65485176
107MAPK110.62317523
108NEK60.62098392
109PDGFRB0.61747193
110PTK2B0.61742224
111MAPK120.61456137
112PRKAA10.61380291
113SYK0.58281853
114MAP3K110.57419517
115ZAP700.56935952
116STK100.56873771
117PIM10.54926148
118CDK40.53944042
119CDK150.52641820
120CDK180.51920359
121PLK20.51770900
122MAP3K50.50794867
123STK30.50165761
124CHEK20.50027213
125SIK30.49585246
126MARK20.47491573
127MAP2K10.46962765
128STK240.46773212
129CDK120.45725797
130PLK30.45324037
131WNK10.44606852
132DAPK20.43903193
133IRAK30.43808790
134TXK0.43510602
135JAK10.41189221
136CDK11A0.41066375
137MAP2K60.40536326
138RPS6KB10.38658328
139JAK30.38555546
140SGK2230.37081989
141SGK4940.37081989
142PDK10.36875262
143CDK140.35765215
144AKT30.35613409
145TRIB30.35599868
146STK110.34677277
147TESK20.34171747
148CHUK0.33485869
149TAOK20.33470124
150MAP3K80.33402242
151PLK40.32115120
152MAP3K120.32056832
153BRD40.31712697
154CAMK40.31664110
155NTRK20.31434620
156GRK50.31217218
157DMPK0.31206819
158VRK10.27903202

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.33360920
2Nicotine addiction_Homo sapiens_hsa050332.68204848
3Leishmaniasis_Homo sapiens_hsa051402.29858564
4* Circadian rhythm_Homo sapiens_hsa047102.26119130
5Primary immunodeficiency_Homo sapiens_hsa053402.17242417
6Synaptic vesicle cycle_Homo sapiens_hsa047212.14690945
7Graft-versus-host disease_Homo sapiens_hsa053321.98593257
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.97320055
9Morphine addiction_Homo sapiens_hsa050321.94287892
10Olfactory transduction_Homo sapiens_hsa047401.92786495
11Staphylococcus aureus infection_Homo sapiens_hsa051501.91338171
12Aldosterone synthesis and secretion_Homo sapiens_hsa049251.91174353
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89432417
14Long-term potentiation_Homo sapiens_hsa047201.87056538
15GABAergic synapse_Homo sapiens_hsa047271.86268427
16Measles_Homo sapiens_hsa051621.83554405
17Allograft rejection_Homo sapiens_hsa053301.80221627
18Tuberculosis_Homo sapiens_hsa051521.79344825
19Autoimmune thyroid disease_Homo sapiens_hsa053201.78790150
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.77972181
21Circadian entrainment_Homo sapiens_hsa047131.77706175
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74119412
23Insulin secretion_Homo sapiens_hsa049111.72140375
24Glutamatergic synapse_Homo sapiens_hsa047241.70884517
25GnRH signaling pathway_Homo sapiens_hsa049121.62308768
26Acute myeloid leukemia_Homo sapiens_hsa052211.57554453
27Hematopoietic cell lineage_Homo sapiens_hsa046401.55800633
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.53064687
29Amphetamine addiction_Homo sapiens_hsa050311.49994735
30Cholinergic synapse_Homo sapiens_hsa047251.49265431
31Oxytocin signaling pathway_Homo sapiens_hsa049211.48586056
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.47913788
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.44433468
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44191490
35Toxoplasmosis_Homo sapiens_hsa051451.41166318
36Influenza A_Homo sapiens_hsa051641.37340552
37Malaria_Homo sapiens_hsa051441.37162670
38Long-term depression_Homo sapiens_hsa047301.34196077
39* Dopaminergic synapse_Homo sapiens_hsa047281.33429752
40Type I diabetes mellitus_Homo sapiens_hsa049401.31035831
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28526135
42Salivary secretion_Homo sapiens_hsa049701.28487334
43Serotonergic synapse_Homo sapiens_hsa047261.21633926
44Ovarian steroidogenesis_Homo sapiens_hsa049131.20558989
45Legionellosis_Homo sapiens_hsa051341.20263861
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19973810
47Viral myocarditis_Homo sapiens_hsa054161.17405935
48B cell receptor signaling pathway_Homo sapiens_hsa046621.17371243
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.16547723
50Antigen processing and presentation_Homo sapiens_hsa046121.16262117
51Pancreatic cancer_Homo sapiens_hsa052121.15690700
52VEGF signaling pathway_Homo sapiens_hsa043701.15284184
53mTOR signaling pathway_Homo sapiens_hsa041501.15009252
54Pancreatic secretion_Homo sapiens_hsa049721.14179698
55Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13271083
56Inositol phosphate metabolism_Homo sapiens_hsa005621.13242997
57Renin secretion_Homo sapiens_hsa049241.13139521
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09652235
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09436760
60Choline metabolism in cancer_Homo sapiens_hsa052311.08911837
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08389456
62Hepatitis C_Homo sapiens_hsa051601.07606159
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06048565
64African trypanosomiasis_Homo sapiens_hsa051431.05959267
65Calcium signaling pathway_Homo sapiens_hsa040201.04578163
66Glioma_Homo sapiens_hsa052141.02241326
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02057863
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01613977
69Pertussis_Homo sapiens_hsa051331.00497763
70* Herpes simplex infection_Homo sapiens_hsa051681.00413037
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.98363393
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97940696
73cAMP signaling pathway_Homo sapiens_hsa040240.97400408
74Phagosome_Homo sapiens_hsa041450.97120229
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95715299
76MAPK signaling pathway_Homo sapiens_hsa040100.94375980
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.94309437
78Apoptosis_Homo sapiens_hsa042100.93221503
79Type II diabetes mellitus_Homo sapiens_hsa049300.93193736
80Rheumatoid arthritis_Homo sapiens_hsa053230.92035660
81Endocytosis_Homo sapiens_hsa041440.91577178
82Colorectal cancer_Homo sapiens_hsa052100.91462350
83Non-homologous end-joining_Homo sapiens_hsa034500.91205516
84Other glycan degradation_Homo sapiens_hsa005110.90999935
85Cell cycle_Homo sapiens_hsa041100.90987071
86RNA degradation_Homo sapiens_hsa030180.90750621
87Lysosome_Homo sapiens_hsa041420.89368936
88Estrogen signaling pathway_Homo sapiens_hsa049150.87876879
89Salmonella infection_Homo sapiens_hsa051320.86454627
90Non-small cell lung cancer_Homo sapiens_hsa052230.86438071
91Cocaine addiction_Homo sapiens_hsa050300.86259130
92Prolactin signaling pathway_Homo sapiens_hsa049170.86247907
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86088289
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.85866009
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83848051
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83242061
97Gastric acid secretion_Homo sapiens_hsa049710.82563092
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.81272804
99Oocyte meiosis_Homo sapiens_hsa041140.79496799
100Alcoholism_Homo sapiens_hsa050340.78076106
101FoxO signaling pathway_Homo sapiens_hsa040680.76339735
102ErbB signaling pathway_Homo sapiens_hsa040120.75547323
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74344711
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73395525
105T cell receptor signaling pathway_Homo sapiens_hsa046600.73066687
106Chronic myeloid leukemia_Homo sapiens_hsa052200.72488046
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69098665
108Amoebiasis_Homo sapiens_hsa051460.67887106
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67882960
110Endometrial cancer_Homo sapiens_hsa052130.66325335
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65745808
112Chemokine signaling pathway_Homo sapiens_hsa040620.63648887
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.63549101
114Renal cell carcinoma_Homo sapiens_hsa052110.63161420
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62843980
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.62826548
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61158875
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61060070
119Glucagon signaling pathway_Homo sapiens_hsa049220.60752351
120Osteoclast differentiation_Homo sapiens_hsa043800.60524641
121Insulin resistance_Homo sapiens_hsa049310.60303052
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59982215
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57755213
124Asthma_Homo sapiens_hsa053100.57625664
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.57396308
126Hepatitis B_Homo sapiens_hsa051610.57304160
127Ras signaling pathway_Homo sapiens_hsa040140.56527922
128Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56210211
129Gap junction_Homo sapiens_hsa045400.55005575
130Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54837669
131Taste transduction_Homo sapiens_hsa047420.53824949
132TNF signaling pathway_Homo sapiens_hsa046680.50285373
133Dilated cardiomyopathy_Homo sapiens_hsa054140.50122449
134Thyroid hormone synthesis_Homo sapiens_hsa049180.49891693
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49644477
136Platelet activation_Homo sapiens_hsa046110.49181354
137Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48050739
138Complement and coagulation cascades_Homo sapiens_hsa046100.47823189
139Rap1 signaling pathway_Homo sapiens_hsa040150.45716917
140Dorso-ventral axis formation_Homo sapiens_hsa043200.45604611
141Central carbon metabolism in cancer_Homo sapiens_hsa052300.44219750
142Bladder cancer_Homo sapiens_hsa052190.43150369
143HTLV-I infection_Homo sapiens_hsa051660.43144833
144HIF-1 signaling pathway_Homo sapiens_hsa040660.42459558
145Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41304222
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40544622
147Epstein-Barr virus infection_Homo sapiens_hsa051690.40202095
148Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39712051
149Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39680914
150Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39650870
151p53 signaling pathway_Homo sapiens_hsa041150.38735180
152Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37556371
153AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37036160
154Viral carcinogenesis_Homo sapiens_hsa052030.36260310
155Shigellosis_Homo sapiens_hsa051310.36252655

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