ARPC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.22564017
2* Arp2/3 complex-mediated actin nucleation (GO:0034314)5.01479503
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.73241356
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.73241356
5antigen processing and presentation of endogenous antigen (GO:0019883)4.46794311
6leukocyte aggregation (GO:0070486)4.29824938
7regulation of B cell receptor signaling pathway (GO:0050855)4.27408125
8positive regulation of gamma-delta T cell activation (GO:0046645)4.19433397
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.03246402
10immunoglobulin mediated immune response (GO:0016064)3.96217339
11neutrophil activation involved in immune response (GO:0002283)3.95966974
12respiratory burst (GO:0045730)3.85619733
13cytidine deamination (GO:0009972)3.84308226
14cytidine metabolic process (GO:0046087)3.84308226
15cytidine catabolic process (GO:0006216)3.84308226
16* actin nucleation (GO:0045010)3.63271953
17regulation of T cell tolerance induction (GO:0002664)3.60334194
18pyrimidine ribonucleoside catabolic process (GO:0046133)3.49343580
19B cell mediated immunity (GO:0019724)3.48783976
20antigen processing and presentation via MHC class Ib (GO:0002475)3.46792507
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.38868593
22positive regulation by symbiont of host defense response (GO:0052509)3.37327876
23modulation by symbiont of host defense response (GO:0052031)3.37327876
24modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.37327876
25modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.37327876
26positive regulation by organism of defense response of other organism involved in symbiotic interact3.37327876
27modulation by symbiont of host immune response (GO:0052553)3.37327876
28regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.34651899
29T cell costimulation (GO:0031295)3.33736952
30regulation of tolerance induction (GO:0002643)3.32100225
31lymphocyte costimulation (GO:0031294)3.29111157
32positive T cell selection (GO:0043368)3.28798131
33detection of other organism (GO:0098543)3.25325992
34sequestering of actin monomers (GO:0042989)3.24671189
35negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.24258629
36negative regulation of cell killing (GO:0031342)3.24258629
37detection of bacterium (GO:0016045)3.23392097
38positive regulation of interferon-alpha production (GO:0032727)3.22239136
39response to peptidoglycan (GO:0032494)3.19975184
40regulation of interferon-beta biosynthetic process (GO:0045357)3.18855989
41negative regulation of phagocytosis (GO:0050765)3.18377540
42ribosomal small subunit assembly (GO:0000028)3.17083323
43cellular extravasation (GO:0045123)3.16052262
44negative thymic T cell selection (GO:0045060)3.13728815
45* positive regulation of lamellipodium assembly (GO:0010592)3.11218170
46pinocytosis (GO:0006907)3.11043927
47B cell receptor signaling pathway (GO:0050853)3.10839426
48regulation of B cell differentiation (GO:0045577)3.09454504
49regulation of interferon-alpha production (GO:0032647)3.09394766
50positive regulation of macrophage differentiation (GO:0045651)3.08246293
51positive regulation of monocyte chemotaxis (GO:0090026)3.07697133
52positive regulation of interleukin-8 secretion (GO:2000484)3.07190424
53positive thymic T cell selection (GO:0045059)3.06269060
54interferon-gamma-mediated signaling pathway (GO:0060333)3.05545048
55T cell migration (GO:0072678)3.02433122
56regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.00711252
57negative T cell selection (GO:0043383)3.00121079
58regulation of gamma-delta T cell differentiation (GO:0045586)2.98573210
59antigen receptor-mediated signaling pathway (GO:0050851)2.98571531
60positive regulation of tolerance induction (GO:0002645)2.95650537
61response to type I interferon (GO:0034340)2.94957594
62type I interferon signaling pathway (GO:0060337)2.93516736
63cellular response to type I interferon (GO:0071357)2.93516736
64regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.93449522
65T cell selection (GO:0045058)2.93355081
66positive regulation of B cell differentiation (GO:0045579)2.92379221
67T cell receptor signaling pathway (GO:0050852)2.91414272
68hepatocyte apoptotic process (GO:0097284)2.90763539
69regulation of dendritic cell antigen processing and presentation (GO:0002604)2.90421606
70regulation of mast cell degranulation (GO:0043304)2.89190063
71myeloid dendritic cell activation (GO:0001773)2.89086828
72neutrophil activation (GO:0042119)2.89061157
73response to protozoan (GO:0001562)2.88921348
74defense response to protozoan (GO:0042832)2.87218467
75positive regulation of T cell mediated cytotoxicity (GO:0001916)2.87148231
76NIK/NF-kappaB signaling (GO:0038061)2.86520478
77regulation of natural killer cell mediated immunity (GO:0002715)2.86217579
78regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.86217579
79regulation of interleukin-12 biosynthetic process (GO:0045075)2.85646535
80regulation of gamma-delta T cell activation (GO:0046643)2.84872660
81regulation of T cell mediated cytotoxicity (GO:0001914)2.84843956
82leukocyte cell-cell adhesion (GO:0007159)2.84155186
83production of molecular mediator involved in inflammatory response (GO:0002532)2.80714351
84regulation of interleukin-2 biosynthetic process (GO:0045076)2.80547234
85cellular response to interferon-gamma (GO:0071346)2.79228857
86barbed-end actin filament capping (GO:0051016)2.78470636
87granulocyte activation (GO:0036230)2.78403261
88regulation of mast cell activation (GO:0033003)2.77931996
89leukocyte degranulation (GO:0043299)2.77790929
90cellular response to zinc ion (GO:0071294)2.77729838
91mast cell activation (GO:0045576)2.77515829
92lymphocyte chemotaxis (GO:0048247)2.76653452
93regulation of regulatory T cell differentiation (GO:0045589)2.76639792
94positive regulation of lymphocyte migration (GO:2000403)2.76265368
95cellular response to interferon-beta (GO:0035458)2.75906370
96negative regulation of T cell mediated immunity (GO:0002710)2.74062716
97response to interferon-beta (GO:0035456)2.73044971
98natural killer cell mediated cytotoxicity (GO:0042267)2.72999218
99natural killer cell mediated immunity (GO:0002228)2.72999218
100regulation of necroptotic process (GO:0060544)2.72202203
101positive regulation of antigen processing and presentation (GO:0002579)2.71605800
102interferon-gamma production (GO:0032609)2.71212613
103regulation of lymphocyte migration (GO:2000401)2.70969209
104myeloid cell activation involved in immune response (GO:0002275)2.70528339
105mature B cell differentiation involved in immune response (GO:0002313)2.67884418
106positive regulation of mast cell activation involved in immune response (GO:0033008)2.67806408
107positive regulation of mast cell degranulation (GO:0043306)2.67806408
108detection of external biotic stimulus (GO:0098581)2.66354097
109regulation of type I interferon-mediated signaling pathway (GO:0060338)2.63894421
110myeloid dendritic cell differentiation (GO:0043011)2.63576464
111regulation of T cell receptor signaling pathway (GO:0050856)2.63393940
112* positive regulation of lamellipodium organization (GO:1902745)2.63345784
113positive regulation of mast cell activation (GO:0033005)2.63099170
114viral transcription (GO:0019083)2.62706255
115negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.62417961
116regulation of response to interferon-gamma (GO:0060330)2.60718826
117thymic T cell selection (GO:0045061)2.60470573
118regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.58948025
119response to interleukin-15 (GO:0070672)2.58916168
120regulation of protein heterodimerization activity (GO:0043497)2.58865329
121positive regulation of isotype switching (GO:0045830)2.57633344
122tolerance induction (GO:0002507)2.56547603
123T cell apoptotic process (GO:0070231)2.54286561
124translational termination (GO:0006415)2.53995510
125negative regulation of interleukin-12 production (GO:0032695)2.53537838
126regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.52951324
127antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.52887583
128JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.52452804
129regulation of alpha-beta T cell proliferation (GO:0046640)2.52165179
130cellular response to interleukin-15 (GO:0071350)2.48997795
131positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.48810934
132regulation of antigen processing and presentation (GO:0002577)2.45950470
133response to muramyl dipeptide (GO:0032495)2.45824456
134positive regulation of alpha-beta T cell proliferation (GO:0046641)2.44675933
135macrophage activation involved in immune response (GO:0002281)2.44106038
136leukocyte mediated cytotoxicity (GO:0001909)2.42913725
137lymphocyte mediated immunity (GO:0002449)2.41914118
138DNA deamination (GO:0045006)2.41753063

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.17341116
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.06404863
3E2F7_22180533_ChIP-Seq_HELA_Human3.88278999
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.34744103
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.22839263
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.22391195
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.07262573
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.03208720
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.00507021
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.94255006
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.84352309
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.76600449
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.69787647
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.65261991
15* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.57326054
16* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56426098
17* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.54364934
18MYC_22102868_ChIP-Seq_BL_Human2.44317874
19* SPI1_23547873_ChIP-Seq_NB4_Human2.38412676
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.37970061
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.27993085
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.26406382
23VDR_21846776_ChIP-Seq_THP-1_Human2.25589057
24* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.24310311
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.22669709
26* MYB_26560356_Chip-Seq_TH2_Human2.17309774
27MAF_26560356_Chip-Seq_TH1_Human2.12393028
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.09751814
29* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.06686089
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.03626408
31* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.00514714
32ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00463781
33* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.91443117
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.91262621
35MYB_26560356_Chip-Seq_TH1_Human1.86341780
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.81305145
37* VDR_24763502_ChIP-Seq_THP-1_Human1.80720035
38SCL_19346495_ChIP-Seq_HPC-7_Human1.77005820
39* UTX_26944678_Chip-Seq_JUKART_Human1.76032692
40* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.75023869
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74769394
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.73527320
43* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.68334331
44RUNX_20019798_ChIP-Seq_JUKART_Human1.55385648
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.54420512
46* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52591197
47TCF7_22412390_ChIP-Seq_EML_Mouse1.51330442
48* SPI1_23127762_ChIP-Seq_K562_Human1.50922792
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37578541
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.37567666
51* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37141503
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36489096
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.36472986
54* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36366996
55* PU_27001747_Chip-Seq_BMDM_Mouse1.35296597
56* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35155821
57E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35143649
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.32782981
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.32320275
60MAF_26560356_Chip-Seq_TH2_Human1.31293865
61CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28685721
62* VDR_23849224_ChIP-Seq_CD4+_Human1.27832808
63* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27776759
64VDR_24787735_ChIP-Seq_THP-1_Human1.26244016
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.25177940
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23830813
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22599302
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22438850
69TFEB_21752829_ChIP-Seq_HELA_Human1.22230267
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21675592
71* GATA3_27048872_Chip-Seq_THYMUS_Human1.17055204
72NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15692914
73BCL6_27268052_Chip-Seq_Bcells_Human1.15186320
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14339077
75ELK1_19687146_ChIP-ChIP_HELA_Human1.13220849
76MYC_18358816_ChIP-ChIP_MESCs_Mouse1.12045035
77XRN2_22483619_ChIP-Seq_HELA_Human1.09072579
78* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09030655
79EST1_17652178_ChIP-ChIP_JURKAT_Human1.07418925
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07180710
81FOXP3_21729870_ChIP-Seq_TREG_Human1.05380283
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03127611
83GATA2_21666600_ChIP-Seq_HMVEC_Human1.02589087
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02416530
85* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01914765
86DCP1A_22483619_ChIP-Seq_HELA_Human1.01764707
87MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01482940
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00762683
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00756992
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00655479
91KDM2B_26808549_Chip-Seq_DND41_Human1.00618464
92* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00496154
93E2F1_21310950_ChIP-Seq_MCF-7_Human1.00323196
94MYC_19030024_ChIP-ChIP_MESCs_Mouse1.00181118
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99611861
96* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99344158
97ETS1_20019798_ChIP-Seq_JURKAT_Human0.99027622
98PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97314735
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97059984
100* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95978862
101RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95853076
102CIITA_25753668_ChIP-Seq_RAJI_Human0.95193681
103LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95101022
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95019068
105CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92740915
106ELF1_20517297_ChIP-Seq_JURKAT_Human0.92651023
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91653521
108JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.88721285
109* GATA3_26560356_Chip-Seq_TH2_Human0.88380187
110PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88303046
111SRF_21415370_ChIP-Seq_HL-1_Mouse0.87883778
112GATA1_22025678_ChIP-Seq_K562_Human0.87756494
113CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86953787
114BCOR_27268052_Chip-Seq_Bcells_Human0.84834889
115SPI1_20517297_ChIP-Seq_HL60_Human0.84785318
116* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84079813
117KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.83623934
118CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83569795
119VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81296359
120P300_27268052_Chip-Seq_Bcells_Human0.78453539
121TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77892440
122GATA1_19941827_ChIP-Seq_MEL_Mouse0.76886278
123STAT1_20625510_ChIP-Seq_HELA_Human0.74442641
124ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.73865703
125VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.73072090

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.03716325
2MP0003436_decreased_susceptibility_to3.40148540
3MP0003303_peritoneal_inflammation3.35275865
4MP0000685_abnormal_immune_system3.06785318
5MP0009785_altered_susceptibility_to3.00569074
6MP0005671_abnormal_response_to2.96490983
7MP0005000_abnormal_immune_tolerance2.79938959
8MP0002148_abnormal_hypersensitivity_rea2.69189880
9MP0005025_abnormal_response_to2.62952402
10MP0001800_abnormal_humoral_immune2.62704174
11MP0002452_abnormal_antigen_presenting2.60317124
12MP0002419_abnormal_innate_immunity2.55005879
13MP0001790_abnormal_immune_system2.54459720
14MP0005387_immune_system_phenotype2.54459720
15MP0001819_abnormal_immune_cell2.41834276
16MP0002420_abnormal_adaptive_immunity2.41806857
17MP0002723_abnormal_immune_serum2.41019031
18MP0003763_abnormal_thymus_physiology2.38324604
19MP0003724_increased_susceptibility_to2.33746796
20MP0006082_CNS_inflammation2.32002587
21MP0002396_abnormal_hematopoietic_system2.17558796
22MP0002398_abnormal_bone_marrow2.11687287
23MP0003300_gastrointestinal_ulcer2.10421695
24MP0002405_respiratory_system_inflammati2.10177797
25MP0005464_abnormal_platelet_physiology2.09109986
26MP0009333_abnormal_splenocyte_physiolog2.07818453
27MP0002166_altered_tumor_susceptibility2.07042827
28MP0003806_abnormal_nucleotide_metabolis1.98619016
29MP0000716_abnormal_immune_system1.94776164
30MP0005058_abnormal_lysosome_morphology1.90401301
31MP0010155_abnormal_intestine_physiology1.90309918
32MP0001853_heart_inflammation1.90153671
33MP0005397_hematopoietic_system_phenotyp1.81055733
34MP0001545_abnormal_hematopoietic_system1.81055733
35MP0001533_abnormal_skeleton_physiology1.80920686
36MP0002006_tumorigenesis1.80001248
37MP0010352_gastrointestinal_tract_polyps1.78298891
38MP0000689_abnormal_spleen_morphology1.77759136
39MP0000858_altered_metastatic_potential1.75554345
40MP0002722_abnormal_immune_system1.74207177
41MP0001845_abnormal_inflammatory_respons1.72766307
42MP0004510_myositis1.72468265
43MP0004808_abnormal_hematopoietic_stem1.71378504
44MP0004947_skin_inflammation1.70528024
45MP0002429_abnormal_blood_cell1.68141604
46MP0000490_abnormal_crypts_of1.63002392
47MP0003448_altered_tumor_morphology1.51134508
48MP0003693_abnormal_embryo_hatching1.49768838
49MP0009278_abnormal_bone_marrow1.47587162
50MP0000343_altered_response_to1.45354319
51MP0001873_stomach_inflammation1.41457564
52MP0000703_abnormal_thymus_morphology1.38105874
53MP0003866_abnormal_defecation1.37365957
54MP0000465_gastrointestinal_hemorrhage1.37140684
55MP0002933_joint_inflammation1.35446689
56MP0008469_abnormal_protein_level1.32766231
57MP0003566_abnormal_cell_adhesion1.32294320
58MP0008260_abnormal_autophagy1.31657923
59MP0003172_abnormal_lysosome_physiology1.20949893
60MP0005451_abnormal_body_composition1.20537257
61MP0006054_spinal_hemorrhage1.17886393
62MP0005310_abnormal_salivary_gland1.16646707
63MP0003828_pulmonary_edema1.12076644
64MP0005023_abnormal_wound_healing1.10943732
65MP0002138_abnormal_hepatobiliary_system1.09018301
66MP0009764_decreased_sensitivity_to1.08628654
67MP0005174_abnormal_tail_pigmentation1.08094466
68MP0005076_abnormal_cell_differentiation1.08021280
69MP0010307_abnormal_tumor_latency1.07614702
70MP0004957_abnormal_blastocyst_morpholog1.06377664
71MP0002019_abnormal_tumor_incidence1.04341709
72MP0005166_decreased_susceptibility_to1.03463051
73MP0001542_abnormal_bone_strength1.01319714
74MP0001851_eye_inflammation1.01153999
75MP0005075_abnormal_melanosome_morpholog1.00462301
76MP0002998_abnormal_bone_remodeling0.96303357
77MP0003075_altered_response_to0.95747268
78MP0008007_abnormal_cellular_replicative0.95724129
79MP0003191_abnormal_cellular_cholesterol0.91335428
80MP0002877_abnormal_melanocyte_morpholog0.90582374
81MP0005390_skeleton_phenotype0.88067866
82MP0004883_abnormal_blood_vessel0.84758661
83MP0003183_abnormal_peptide_metabolism0.84688213
84MP0003077_abnormal_cell_cycle0.82965317
85MP0009840_abnormal_foam_cell0.80923672
86MP0003045_fibrosis0.80722574
87MP0000015_abnormal_ear_pigmentation0.78493187
88MP0003705_abnormal_hypodermis_morpholog0.76456578
89MP0003453_abnormal_keratinocyte_physiol0.74703923
90MP0005165_increased_susceptibility_to0.74474397
91MP0009763_increased_sensitivity_to0.74341941
92MP0003795_abnormal_bone_structure0.72921332
93MP0009765_abnormal_xenobiotic_induced0.72867760
94MP0002277_abnormal_respiratory_mucosa0.72809021
95MP0000249_abnormal_blood_vessel0.72772391
96MP0001663_abnormal_digestive_system0.70610430
97MP0010234_abnormal_vibrissa_follicle0.69394186
98MP0000604_amyloidosis0.68189499
99MP0003111_abnormal_nucleus_morphology0.67099202
100MP0003279_aneurysm0.67008307
101MP0003091_abnormal_cell_migration0.66499638
102MP0000313_abnormal_cell_death0.65807008
103MP0010094_abnormal_chromosome_stability0.65525043
104MP0003186_abnormal_redox_activity0.64872386
105MP0001958_emphysema0.64519454
106MP0000477_abnormal_intestine_morphology0.64065875
107MP0005084_abnormal_gallbladder_morpholo0.63192546
108MP0004381_abnormal_hair_follicle0.60798916
109MP0008004_abnormal_stomach_pH0.60370120
110MP0005164_abnormal_response_to0.59928770
111MP0002136_abnormal_kidney_physiology0.59163605
112MP0002132_abnormal_respiratory_system0.58845483
113MP0001243_abnormal_dermal_layer0.54306368
114MP0003950_abnormal_plasma_membrane0.53676421
115MP0005319_abnormal_enzyme/_coenzyme0.53593745
116MP0008873_increased_physiological_sensi0.52618646
117MP0006036_abnormal_mitochondrial_physio0.52348894
118MP0005584_abnormal_enzyme/coenzyme_acti0.51772734
119MP0003786_premature_aging0.51228186

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.41989562
2Recurrent abscess formation (HP:0002722)5.74070623
3Recurrent bacterial skin infections (HP:0005406)5.05330969
4Elevated erythrocyte sedimentation rate (HP:0003565)4.59077791
5Recurrent gram-negative bacterial infections (HP:0005420)4.22944760
6Myositis (HP:0100614)4.16137451
7Abnormality of macrophages (HP:0004311)4.02858318
8Chronic obstructive pulmonary disease (HP:0006510)3.92364698
9Obstructive lung disease (HP:0006536)3.92364698
10Recurrent fungal infections (HP:0002841)3.92004126
11Vacuolated lymphocytes (HP:0001922)3.89330687
12Mediastinal lymphadenopathy (HP:0100721)3.72755579
13IgM deficiency (HP:0002850)3.54540879
14Chronic otitis media (HP:0000389)3.48933744
15Autoimmune hemolytic anemia (HP:0001890)3.41167370
16Thrombocytosis (HP:0001894)3.33130897
17Recurrent skin infections (HP:0001581)3.31197146
18Recurrent viral infections (HP:0004429)3.29362832
19Stomatitis (HP:0010280)3.26379472
20Cellulitis (HP:0100658)3.23996686
21Recurrent bronchitis (HP:0002837)3.13110061
22Abnormality of glycolipid metabolism (HP:0010969)3.09268183
23Abnormality of liposaccharide metabolism (HP:0010968)3.09268183
24Abnormality of glycosphingolipid metabolism (HP:0004343)3.09268183
25Gingivitis (HP:0000230)3.07524771
26Orchitis (HP:0100796)3.06615553
27Increased cerebral lipofuscin (HP:0011813)3.04654002
28Meningitis (HP:0001287)3.03073083
29Petechiae (HP:0000967)3.01631504
30Spontaneous hematomas (HP:0007420)2.99159998
31Abnormality of T cell physiology (HP:0011840)2.98197027
32Abnormality of T cells (HP:0002843)2.95919520
33Pustule (HP:0200039)2.95717863
34Increased neuronal autofluorescent lipopigment (HP:0002074)2.91280834
35Interstitial pulmonary disease (HP:0006530)2.85271719
36Autoimmune thrombocytopenia (HP:0001973)2.84364893
37Vasculitis (HP:0002633)2.81526777
38Recurrent cutaneous fungal infections (HP:0011370)2.79018098
39Chronic mucocutaneous candidiasis (HP:0002728)2.79018098
40Chronic diarrhea (HP:0002028)2.75840908
41Retrobulbar optic neuritis (HP:0100654)2.65813172
42Optic neuritis (HP:0100653)2.65813172
43Abnormality of T cell number (HP:0011839)2.64944030
44Abnormality of the nasal mucosa (HP:0000433)2.61201251
45Nasal polyposis (HP:0100582)2.61177307
46T lymphocytopenia (HP:0005403)2.58829414
47Panhypogammaglobulinemia (HP:0003139)2.55233877
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.54413104
49Dysostosis multiplex (HP:0000943)2.53856195
50Lymphopenia (HP:0001888)2.53220496
51Abnormality of cells of the lymphoid lineage (HP:0012140)2.53014792
52Urticaria (HP:0001025)2.52540290
53Increased IgM level (HP:0003496)2.51488598
54Skin rash (HP:0000988)2.49070723
55Hypergammaglobulinemia (HP:0010702)2.47050782
56IgG deficiency (HP:0004315)2.45909628
57Gangrene (HP:0100758)2.45472275
58Basal ganglia calcification (HP:0002135)2.44663697
59Hepatosplenomegaly (HP:0001433)2.42925524
60Severe combined immunodeficiency (HP:0004430)2.42671753
61Leukocytosis (HP:0001974)2.40421685
62Periodontitis (HP:0000704)2.36783107
63Arterial thrombosis (HP:0004420)2.36621497
64Keratoconjunctivitis (HP:0001096)2.35343853
65Abnormality of the pleura (HP:0002103)2.34635805
66Prolonged bleeding time (HP:0003010)2.33220170
67Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.33035544
68Gingival bleeding (HP:0000225)2.32537650
69Disinhibition (HP:0000734)2.32367549
70Combined immunodeficiency (HP:0005387)2.31725742
71Glomerulopathy (HP:0100820)2.31145092
72Inflammation of the large intestine (HP:0002037)2.28589528
73Osteomyelitis (HP:0002754)2.28426278
74Increased IgE level (HP:0003212)2.28172582
75Gastrointestinal inflammation (HP:0004386)2.26690211
76Pulmonary fibrosis (HP:0002206)2.22757591
77Chest pain (HP:0100749)2.22507624
78Hemoptysis (HP:0002105)2.21846319
79Purpura (HP:0000979)2.21659495
80Hematochezia (HP:0002573)2.20005897
81Acute hepatic failure (HP:0006554)2.18852822
82Poor head control (HP:0002421)2.18257402
83Pulmonary infiltrates (HP:0002113)2.17455412
84Hypoproteinemia (HP:0003075)2.14383808
85Recurrent pneumonia (HP:0006532)2.13879964
86Anorexia (HP:0002039)2.13834425
87Skin ulcer (HP:0200042)2.13322443
88Agammaglobulinemia (HP:0004432)2.12418521
89Joint swelling (HP:0001386)2.11395881
90Encephalitis (HP:0002383)2.11153670
91Recurrent lower respiratory tract infections (HP:0002783)2.10313743
92Pulmonary embolism (HP:0002204)2.09616762
93Abnormal platelet volume (HP:0011876)2.07835294
94Mucopolysacchariduria (HP:0008155)2.07352143
95Urinary glycosaminoglycan excretion (HP:0003541)2.07352143
96Epistaxis (HP:0000421)2.06574770
97Amaurosis fugax (HP:0100576)2.06378451
98Eosinophilia (HP:0001880)2.05978146
99Granulocytopenia (HP:0001913)2.05864204
100Impaired platelet aggregation (HP:0003540)2.05225916
101Abnormal platelet function (HP:0011869)2.05225916
102Papilloma (HP:0012740)2.05150945
103Verrucae (HP:0200043)2.05150945
104Systemic lupus erythematosus (HP:0002725)2.05067116
105Abnormality of the prostate (HP:0008775)2.02060463
106Polyneuropathy (HP:0001271)2.01144763
107Increased density of long bones (HP:0006392)2.00200127
108Abnormality of eosinophils (HP:0001879)1.98389950
109Agnosia (HP:0010524)1.96523315
110Lymphoma (HP:0002665)1.96501324
111Abnormality of the pericardium (HP:0001697)1.96343197
112Aplastic anemia (HP:0001915)1.95395568
113Increased serum ferritin (HP:0003281)1.94379780
114Sepsis (HP:0100806)1.94007534
115IgA deficiency (HP:0002720)1.93320165
116Vertebral compression fractures (HP:0002953)1.93209814
117Premature loss of primary teeth (HP:0006323)1.92128305
118Hypertensive crisis (HP:0100735)1.91969322
119Abnormality of cells of the erythroid lineage (HP:0012130)1.90841821
120Gastrointestinal infarctions (HP:0005244)1.90111401
121Keratoconjunctivitis sicca (HP:0001097)1.90103068
122Emphysema (HP:0002097)1.89452306
123Spondylolisthesis (HP:0003302)1.89327463
124Diminished motivation (HP:0000745)1.87725542
125Gastrointestinal stroma tumor (HP:0100723)1.87471175
126Abnormality of B cell number (HP:0010975)1.87338817
127B lymphocytopenia (HP:0010976)1.87338817

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.96218164
2BLK3.22175380
3KDR2.73197124
4PIM22.70598480
5NME22.64240402
6ZAP702.54736481
7TESK22.52583402
8TXK2.39886631
9IRAK42.36497363
10RIPK42.31794330
11TBK12.28652868
12JAK32.05753658
13KIT2.04241026
14TESK11.98757471
15TRIB31.96308361
16TYK21.95295219
17ERN11.93294741
18BTK1.85468309
19BMPR21.83391539
20MAP3K141.80386034
21TEC1.78226010
22STK101.76725925
23MAP3K121.74225122
24EIF2AK11.73987374
25BCKDK1.64385158
26RPS6KA41.59035328
27LRRK21.58837588
28IKBKE1.53850485
29PKN21.52853222
30SYK1.50784112
31SCYL21.49586061
32CSF1R1.39761226
33CSK1.39277436
34NEK91.35230153
35GRK71.35209698
36MAP2K31.31469043
37MAP3K111.30219682
38ITK1.29972960
39IKBKB1.21908390
40LCK1.19926117
41GRK61.17437769
42PIK3CG1.17175244
43HCK1.17064129
44LYN1.11350776
45PIM11.11010677
46PAK41.08985218
47JAK11.02610029
48FES0.96412460
49ARAF0.96314666
50TGFBR20.96241532
51EIF2AK30.96150230
52IRAK30.96080282
53CDK190.94327675
54VRK20.89173911
55ACVR1B0.86390731
56TNK20.82831885
57MAP3K100.82812483
58TAOK30.82257089
59TGFBR10.80463163
60FLT30.80141847
61TAOK20.79074763
62MARK30.78908010
63NLK0.78869535
64EEF2K0.78046493
65PRPF4B0.76790842
66ILK0.76328618
67MAP3K130.75786608
68CDK60.74910697
69NEK20.74848469
70FGFR40.73264106
71WEE10.73212032
72MAP3K50.73002410
73MAP3K80.71590731
74MST40.70078849
75CLK10.67862421
76MOS0.66785145
77CHUK0.64787925
78MATK0.64113024
79MAP3K30.63368012
80LIMK10.62457429
81JAK20.61875412
82BUB10.61149991
83MAPKAPK30.61025420
84ABL20.61008054
85NUAK10.59396507
86FGFR30.57382541
87RAF10.56249057
88MAPKAPK20.54894518
89RIPK10.53053461
90TTN0.52633233
91DYRK1B0.51851594
92FYN0.50376735
93CDK40.49658085
94STK40.47419656
95PRKG20.47179089
96PTK60.46894661
97ABL10.46648841
98DMPK0.45096609
99PDK10.44280690
100EPHB10.43782564
101TAOK10.43695820
102CAMKK20.43353755
103PRKCD0.43031136
104RPS6KB20.42949231
105MAP3K10.42402937
106ADRBK20.42199186
107DAPK10.39937637
108ALK0.39487452
109PRKCQ0.39149357
110EGFR0.39074347
111IGF1R0.38532989
112TRPM70.38319843
113PAK10.38237845
114MAP2K60.38069364
115DAPK30.37541952
116MAPK110.36787934
117SIK30.33957945
118FGR0.33217723
119CDC70.32697457
120MYLK0.32135787
121AURKB0.31078428
122MAP4K20.30243110
123INSR0.26510277
124PTK2B0.25501901
125TLK10.22078173
126MAPK120.19109308

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.83174938
2Primary immunodeficiency_Homo sapiens_hsa053402.74589743
3Antigen processing and presentation_Homo sapiens_hsa046122.20732723
4Osteoclast differentiation_Homo sapiens_hsa043802.05514986
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.00848664
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.00312976
7Measles_Homo sapiens_hsa051621.94726882
8B cell receptor signaling pathway_Homo sapiens_hsa046621.94486100
9* Shigellosis_Homo sapiens_hsa051311.93562957
10Legionellosis_Homo sapiens_hsa051341.91310727
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.87206619
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.86189900
13DNA replication_Homo sapiens_hsa030301.85559231
14Ribosome_Homo sapiens_hsa030101.83032048
15Allograft rejection_Homo sapiens_hsa053301.80118489
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79777094
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.77063335
18Pertussis_Homo sapiens_hsa051331.72644947
19Proteasome_Homo sapiens_hsa030501.69880706
20Graft-versus-host disease_Homo sapiens_hsa053321.69156121
21Hematopoietic cell lineage_Homo sapiens_hsa046401.68815389
22* Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.62961846
23Tuberculosis_Homo sapiens_hsa051521.62328205
24Viral myocarditis_Homo sapiens_hsa054161.61601554
25* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.60579095
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.55357832
27Herpes simplex infection_Homo sapiens_hsa051681.55057042
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.54080210
29T cell receptor signaling pathway_Homo sapiens_hsa046601.51553969
30Other glycan degradation_Homo sapiens_hsa005111.51374699
31* Salmonella infection_Homo sapiens_hsa051321.49629035
32Asthma_Homo sapiens_hsa053101.45860854
33Toxoplasmosis_Homo sapiens_hsa051451.45213445
34Apoptosis_Homo sapiens_hsa042101.41932361
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41165483
36Staphylococcus aureus infection_Homo sapiens_hsa051501.40436846
37Malaria_Homo sapiens_hsa051441.37707752
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33872454
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32088924
40Hepatitis B_Homo sapiens_hsa051611.30818594
41Influenza A_Homo sapiens_hsa051641.29730239
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.29704343
43* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.29399021
44Lysosome_Homo sapiens_hsa041421.29165226
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.23652100
46TNF signaling pathway_Homo sapiens_hsa046681.21913930
47Chemokine signaling pathway_Homo sapiens_hsa040621.17214253
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.15032245
49Acute myeloid leukemia_Homo sapiens_hsa052211.14573074
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13534230
51Platelet activation_Homo sapiens_hsa046111.11821117
52Base excision repair_Homo sapiens_hsa034101.11475476
53p53 signaling pathway_Homo sapiens_hsa041151.07705793
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03501064
55Mismatch repair_Homo sapiens_hsa034301.03087224
56Chronic myeloid leukemia_Homo sapiens_hsa052201.01252560
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01057746
58Phagosome_Homo sapiens_hsa041450.99753816
59Epstein-Barr virus infection_Homo sapiens_hsa051690.99205227
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96491992
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94811727
62Pancreatic cancer_Homo sapiens_hsa052120.92062249
63Spliceosome_Homo sapiens_hsa030400.86937987
64Autoimmune thyroid disease_Homo sapiens_hsa053200.83585013
65Oxidative phosphorylation_Homo sapiens_hsa001900.82425098
66HTLV-I infection_Homo sapiens_hsa051660.82096624
67VEGF signaling pathway_Homo sapiens_hsa043700.81831481
68Viral carcinogenesis_Homo sapiens_hsa052030.78250111
69Hepatitis C_Homo sapiens_hsa051600.74702399
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.72865995
71Cell cycle_Homo sapiens_hsa041100.72422621
72Rheumatoid arthritis_Homo sapiens_hsa053230.72325316
73Type I diabetes mellitus_Homo sapiens_hsa049400.71592478
74Homologous recombination_Homo sapiens_hsa034400.71506937
75Small cell lung cancer_Homo sapiens_hsa052220.71222225
76Parkinsons disease_Homo sapiens_hsa050120.68457120
77Nucleotide excision repair_Homo sapiens_hsa034200.67231917
78Pentose phosphate pathway_Homo sapiens_hsa000300.65782531
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63865812
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62603038
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60655865
82HIF-1 signaling pathway_Homo sapiens_hsa040660.59335427
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59312978
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58695754
85Thyroid cancer_Homo sapiens_hsa052160.58361554
86Pyrimidine metabolism_Homo sapiens_hsa002400.57915016
87* Endocytosis_Homo sapiens_hsa041440.57413195
88* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56134763
89Collecting duct acid secretion_Homo sapiens_hsa049660.53886876
90Amoebiasis_Homo sapiens_hsa051460.53246032
91Prolactin signaling pathway_Homo sapiens_hsa049170.52432574
92RNA transport_Homo sapiens_hsa030130.52299723
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52002198
94Colorectal cancer_Homo sapiens_hsa052100.50907119
95Non-small cell lung cancer_Homo sapiens_hsa052230.48491271
96Proteoglycans in cancer_Homo sapiens_hsa052050.47279249
97African trypanosomiasis_Homo sapiens_hsa051430.47188781
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.47163075
99Adherens junction_Homo sapiens_hsa045200.42387176
100Bladder cancer_Homo sapiens_hsa052190.41468054
101Systemic lupus erythematosus_Homo sapiens_hsa053220.40763039
102Regulation of autophagy_Homo sapiens_hsa041400.39876842
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39251825
104N-Glycan biosynthesis_Homo sapiens_hsa005100.38905255
105Protein export_Homo sapiens_hsa030600.37792168
106Renin-angiotensin system_Homo sapiens_hsa046140.36692605
107Caffeine metabolism_Homo sapiens_hsa002320.36353430
108Focal adhesion_Homo sapiens_hsa045100.33505413
109Alzheimers disease_Homo sapiens_hsa050100.33323627
110MicroRNAs in cancer_Homo sapiens_hsa052060.32599759
111Galactose metabolism_Homo sapiens_hsa000520.32232992
112Vibrio cholerae infection_Homo sapiens_hsa051100.26740160
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24547565
114Sulfur metabolism_Homo sapiens_hsa009200.22197967
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16940546
116Huntingtons disease_Homo sapiens_hsa050160.13926335
117RNA polymerase_Homo sapiens_hsa030200.13286139
118Arachidonic acid metabolism_Homo sapiens_hsa005900.13284978
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.12190762
120Glutathione metabolism_Homo sapiens_hsa004800.06696102

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