ARPC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.95915317
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.95915317
3antigen processing and presentation of endogenous antigen (GO:0019883)5.68304814
4positive regulation of gamma-delta T cell activation (GO:0046645)4.49667927
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.45854780
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.45854780
7modulation by symbiont of host immune response (GO:0052553)4.45854780
8positive regulation by symbiont of host defense response (GO:0052509)4.45854780
9modulation by symbiont of host defense response (GO:0052031)4.45854780
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.45854780
11regulation of B cell receptor signaling pathway (GO:0050855)4.42438624
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.15501990
13regulation of interferon-beta biosynthetic process (GO:0045357)4.04623709
14negative regulation of phagocytosis (GO:0050765)3.89908366
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.84054875
16positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.74798884
17immunoglobulin mediated immune response (GO:0016064)3.74132603
18regulation of gamma-delta T cell differentiation (GO:0045586)3.61272441
19* Arp2/3 complex-mediated actin nucleation (GO:0034314)3.58762725
20ATP synthesis coupled proton transport (GO:0015986)3.53011884
21energy coupled proton transport, down electrochemical gradient (GO:0015985)3.53011884
22pentose-phosphate shunt (GO:0006098)3.52325203
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.51724800
24antigen processing and presentation via MHC class Ib (GO:0002475)3.47044060
25positive regulation of B cell differentiation (GO:0045579)3.46448083
26positive thymic T cell selection (GO:0045059)3.34319513
27regulation of gamma-delta T cell activation (GO:0046643)3.34101593
28positive regulation of interferon-alpha production (GO:0032727)3.31287539
29detection of other organism (GO:0098543)3.28552014
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.27305012
31negative regulation of cell killing (GO:0031342)3.27305012
32neutrophil activation (GO:0042119)3.26784637
33antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.25147832
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.22530342
35protein targeting to ER (GO:0045047)3.20922333
36regulation of interferon-alpha production (GO:0032647)3.19218478
37T cell apoptotic process (GO:0070231)3.18620439
38detection of bacterium (GO:0016045)3.18488825
39B cell receptor signaling pathway (GO:0050853)3.17795318
40positive regulation of mast cell activation (GO:0033005)3.17374202
41cotranslational protein targeting to membrane (GO:0006613)3.16738215
42polyketide metabolic process (GO:0030638)3.16548309
43doxorubicin metabolic process (GO:0044598)3.16548309
44daunorubicin metabolic process (GO:0044597)3.16548309
45regulation of interleukin-12 biosynthetic process (GO:0045075)3.15296501
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.13862644
47granulocyte activation (GO:0036230)3.13477385
48leukocyte aggregation (GO:0070486)3.13172788
49macrophage activation involved in immune response (GO:0002281)3.10733402
50B cell mediated immunity (GO:0019724)3.09222596
51negative regulation of interleukin-12 production (GO:0032695)3.08836847
52response to interferon-beta (GO:0035456)3.08706314
53positive regulation of mast cell degranulation (GO:0043306)3.07280044
54positive regulation of mast cell activation involved in immune response (GO:0033008)3.07280044
55protein localization to endoplasmic reticulum (GO:0070972)3.07237812
56establishment of protein localization to endoplasmic reticulum (GO:0072599)3.06282325
57regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.04032246
58NADPH regeneration (GO:0006740)3.03010586
59positive regulation of lamellipodium assembly (GO:0010592)3.02779468
60regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.01244669
61regulation of mast cell degranulation (GO:0043304)3.01113526
62regulation of T cell tolerance induction (GO:0002664)3.00484112
63regulation of protein heterodimerization activity (GO:0043497)2.97991344
64ribosomal small subunit biogenesis (GO:0042274)2.96601124
65response to host immune response (GO:0052572)2.95350000
66response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.95350000
67detection of molecule of bacterial origin (GO:0032490)2.94007756
68regulation of B cell differentiation (GO:0045577)2.92833589
69cellular extravasation (GO:0045123)2.91979643
70regulation of tolerance induction (GO:0002643)2.91619519
71positive regulation of monocyte chemotaxis (GO:0090026)2.88485666
72response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.86586719
73response to host (GO:0075136)2.86586719
74response to host defenses (GO:0052200)2.86586719
75positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.86420552
76response to peptidoglycan (GO:0032494)2.86242124
77regulation of mast cell activation (GO:0033003)2.84630289
78microglial cell activation (GO:0001774)2.84486391
79negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.84397033
80tolerance induction (GO:0002507)2.83642692
81viral transcription (GO:0019083)2.83449464
82pinocytosis (GO:0006907)2.83408637
83regulation of type I interferon-mediated signaling pathway (GO:0060338)2.81254352
84positive regulation of histone deacetylation (GO:0031065)2.79979728
85positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.79228517
86positive regulation of antigen processing and presentation (GO:0002579)2.78674995
87detection of external biotic stimulus (GO:0098581)2.75916029
88JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.75905198
89regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.75388938
90antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.74759175
91neutrophil activation involved in immune response (GO:0002283)2.74174843
92leukocyte degranulation (GO:0043299)2.73557826
93respiratory burst (GO:0045730)2.73375599
94regulation of mast cell activation involved in immune response (GO:0033006)2.72520338
95ribosomal small subunit assembly (GO:0000028)2.72080632
96viral life cycle (GO:0019058)2.70790492
97hepatocyte apoptotic process (GO:0097284)2.70761989
98lymphocyte apoptotic process (GO:0070227)2.70034976
99thymic T cell selection (GO:0045061)2.69634562
100negative thymic T cell selection (GO:0045060)2.68972393
101regulation of antigen processing and presentation (GO:0002577)2.68508834
102mast cell activation (GO:0045576)2.67730251
103translational termination (GO:0006415)2.66351406
104response to type I interferon (GO:0034340)2.65723571
105regulation of alpha-beta T cell proliferation (GO:0046640)2.65573701
106leukocyte cell-cell adhesion (GO:0007159)2.64022561
107positive regulation of lamellipodium organization (GO:1902745)2.63902765
108negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.63882871
109regulation of response to interferon-gamma (GO:0060330)2.63754306
110cellular response to interferon-gamma (GO:0071346)2.63385783
111respiratory electron transport chain (GO:0022904)2.63262707
112type I interferon signaling pathway (GO:0060337)2.62849274
113cellular response to type I interferon (GO:0071357)2.62849274
114response to fungus (GO:0009620)2.62390044
115myeloid dendritic cell differentiation (GO:0043011)2.62245890
116negative T cell selection (GO:0043383)2.61690479
117barbed-end actin filament capping (GO:0051016)2.60575900
118morphogenesis of an endothelium (GO:0003159)2.59599342
119endothelial tube morphogenesis (GO:0061154)2.59599342
120defense response to protozoan (GO:0042832)2.59547651
121interferon-gamma-mediated signaling pathway (GO:0060333)2.58434995
122protein neddylation (GO:0045116)2.58309635
123negative regulation of granulocyte differentiation (GO:0030853)2.57061785
124NIK/NF-kappaB signaling (GO:0038061)2.56426379
125T cell costimulation (GO:0031295)2.56386563
126* actin nucleation (GO:0045010)2.56110250
127negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.55886235
128electron transport chain (GO:0022900)2.55845167
129myeloid dendritic cell activation (GO:0001773)2.55269903
130positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.55192152
131T cell migration (GO:0072678)2.54972841
132regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.53945397
133lymphocyte costimulation (GO:0031294)2.53298391
134regulation of dendritic cell antigen processing and presentation (GO:0002604)2.52797228
135response to interferon-gamma (GO:0034341)2.51446644
136purine deoxyribonucleotide catabolic process (GO:0009155)2.50919994
137lipopolysaccharide-mediated signaling pathway (GO:0031663)2.50154594
138positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.50147017
139regulation of myeloid leukocyte mediated immunity (GO:0002886)2.50080045
140negative regulation of erythrocyte differentiation (GO:0045647)2.49865473
141response to protozoan (GO:0001562)2.49340363
142response to muramyl dipeptide (GO:0032495)2.48836309
143cytidine deamination (GO:0009972)2.48431259
144cytidine catabolic process (GO:0006216)2.48431259
145defense response to fungus (GO:0050832)2.44560229
146glucose catabolic process (GO:0006007)2.43386271
147myeloid cell activation involved in immune response (GO:0002275)2.43170694
148translational elongation (GO:0006414)2.41193792
149low-density lipoprotein particle clearance (GO:0034383)2.40674808
150lymphocyte homeostasis (GO:0002260)2.40624288
151mannose metabolic process (GO:0006013)2.40333955

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.69474042
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.53824677
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.50498442
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.34625706
5MYC_22102868_ChIP-Seq_BL_Human3.30627677
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.01277811
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.93974031
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.93809107
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.89919166
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.89365678
11VDR_21846776_ChIP-Seq_THP-1_Human2.81422123
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.68058761
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.66726313
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.53358839
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.46741220
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.44979310
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.44549123
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39415974
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.37036862
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35896047
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.34390231
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.32192101
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.30059568
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.28110819
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.21391749
26* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17625229
27MAF_26560356_Chip-Seq_TH1_Human2.17548100
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.08445812
29* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.07268140
30BRD4_27068464_Chip-Seq_AML-cells_Mouse2.06744713
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.00817729
32UTX_26944678_Chip-Seq_JUKART_Human1.96014716
33SCL_19346495_ChIP-Seq_HPC-7_Human1.95742788
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.95033754
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94270522
36VDR_24763502_ChIP-Seq_THP-1_Human1.93998368
37MYB_26560356_Chip-Seq_TH2_Human1.93841606
38* TCF7_22412390_ChIP-Seq_EML_Mouse1.93122907
39* VDR_23849224_ChIP-Seq_CD4+_Human1.89172196
40* SPI1_23547873_ChIP-Seq_NB4_Human1.88900802
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.86826654
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.85094455
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.80341745
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79922810
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.79817941
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79704784
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.75328167
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.65199400
49MYB_26560356_Chip-Seq_TH1_Human1.64783005
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62638780
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.62089187
52FOXP3_21729870_ChIP-Seq_TREG_Human1.60859203
53* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.60666719
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59158113
55* SPI1_23127762_ChIP-Seq_K562_Human1.59134258
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58337188
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58073115
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57258554
59* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56850760
60KDM2B_26808549_Chip-Seq_DND41_Human1.55975955
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55533098
62MAF_26560356_Chip-Seq_TH2_Human1.47562878
63LXR_22292898_ChIP-Seq_THP-1_Human1.47106228
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45063977
65RUNX_20019798_ChIP-Seq_JUKART_Human1.44289296
66* ELK1_19687146_ChIP-ChIP_HELA_Human1.42224862
67* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.41063421
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.40435501
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40386697
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39092077
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38858075
72HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38422509
73* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37974536
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34389948
75* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32733944
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31761193
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30362150
78GATA3_26560356_Chip-Seq_TH2_Human1.29602033
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29280296
80MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27944628
81TP63_17297297_ChIP-ChIP_HaCaT_Human1.26977809
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26146831
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22743174
84GATA1_22025678_ChIP-Seq_K562_Human1.22682405
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22015794
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18449091
87DCP1A_22483619_ChIP-Seq_HELA_Human1.17869692
88LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14325801
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13839453
90E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13324800
91GATA1_19941827_ChIP-Seq_MEL_Mouse1.13173218
92RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13054285
93PU_27001747_Chip-Seq_BMDM_Mouse1.12369703
94RACK7_27058665_Chip-Seq_MCF-7_Human1.11912058
95CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11775445
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11767843
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10195871
98* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09839366
99* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09770330
100GATA3_27048872_Chip-Seq_THYMUS_Human1.09693712
101Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09501497
102MYC_18555785_ChIP-Seq_MESCs_Mouse1.09086864
103NCOR1_26117541_ChIP-Seq_K562_Human1.08604381
104FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07499474
105* GABP_19822575_ChIP-Seq_HepG2_Human1.06658055
106CIITA_25753668_ChIP-Seq_RAJI_Human1.04053013
107CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03879010
108ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03066572
109PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02653341
110CLOCK_20551151_ChIP-Seq_293T_Human1.02565754
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02180118
112CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02173383
113ATF3_27146783_Chip-Seq_COLON_Human1.02089508
114TFEB_21752829_ChIP-Seq_HELA_Human1.01516250
115ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.00070947
116STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99145820
117MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99121518
118STAT1_20625510_ChIP-Seq_HELA_Human0.98221096
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97919668
120ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95216407
121STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94954058
122NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94850131
123ELK1_22589737_ChIP-Seq_MCF10A_Human0.94400116
124* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93799296
125NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93104332
126HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92909323
127BCL6_27268052_Chip-Seq_Bcells_Human0.92859923
128PPARA_22158963_ChIP-Seq_LIVER_Mouse0.92223063
129SPI1_20517297_ChIP-Seq_HL60_Human0.91393255
130FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.91173208
131TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90569154
132MYC_19079543_ChIP-ChIP_MESCs_Mouse0.89857496
133E2F4_17652178_ChIP-ChIP_JURKAT_Human0.89844826
134GATA1_19941826_ChIP-Seq_K562_Human0.89750000
135PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88708277
136* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87771116
137BCOR_27268052_Chip-Seq_Bcells_Human0.87708254
138ELF1_20517297_ChIP-Seq_JURKAT_Human0.87578414
139XRN2_22483619_ChIP-Seq_HELA_Human0.87171860
140ZNF263_19887448_ChIP-Seq_K562_Human0.86044592
141ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85437717

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.77168284
2MP0001835_abnormal_antigen_presentation3.33498960
3MP0003300_gastrointestinal_ulcer3.03034918
4MP0003436_decreased_susceptibility_to2.93371432
5MP0003806_abnormal_nucleotide_metabolis2.83355717
6MP0000685_abnormal_immune_system2.76268251
7MP0001800_abnormal_humoral_immune2.56868776
8MP0005387_immune_system_phenotype2.45401425
9MP0001790_abnormal_immune_system2.45401425
10MP0009785_altered_susceptibility_to2.43210691
11MP0005000_abnormal_immune_tolerance2.38524875
12MP0002452_abnormal_antigen_presenting2.35309124
13MP0005058_abnormal_lysosome_morphology2.32115500
14MP0002419_abnormal_innate_immunity2.27561850
15MP0005671_abnormal_response_to2.27389427
16MP0005025_abnormal_response_to2.23706174
17MP0005464_abnormal_platelet_physiology2.19199435
18MP0002723_abnormal_immune_serum2.15659479
19MP0002420_abnormal_adaptive_immunity2.15508061
20MP0001819_abnormal_immune_cell2.14349455
21MP0004510_myositis2.03322897
22MP0006082_CNS_inflammation1.98425482
23MP0002398_abnormal_bone_marrow1.98155333
24MP0009840_abnormal_foam_cell1.94837681
25MP0004947_skin_inflammation1.92559546
26MP0009333_abnormal_splenocyte_physiolog1.90132751
27MP0002396_abnormal_hematopoietic_system1.89605441
28MP0003191_abnormal_cellular_cholesterol1.89144990
29MP0002148_abnormal_hypersensitivity_rea1.86581262
30MP0010352_gastrointestinal_tract_polyps1.85318965
31MP0002405_respiratory_system_inflammati1.81450609
32MP0000716_abnormal_immune_system1.79211713
33MP0010155_abnormal_intestine_physiology1.76867319
34MP0003705_abnormal_hypodermis_morpholog1.76489473
35MP0002166_altered_tumor_susceptibility1.76348433
36MP0003566_abnormal_cell_adhesion1.75935740
37MP0003763_abnormal_thymus_physiology1.75916023
38MP0009278_abnormal_bone_marrow1.72518485
39MP0003172_abnormal_lysosome_physiology1.72474277
40MP0000689_abnormal_spleen_morphology1.71900555
41MP0005397_hematopoietic_system_phenotyp1.69660857
42MP0001545_abnormal_hematopoietic_system1.69660857
43MP0001845_abnormal_inflammatory_respons1.69190057
44MP0002722_abnormal_immune_system1.67965472
45MP0001873_stomach_inflammation1.67811862
46MP0001533_abnormal_skeleton_physiology1.64422546
47MP0000465_gastrointestinal_hemorrhage1.61200820
48MP0002429_abnormal_blood_cell1.60185093
49MP0003724_increased_susceptibility_to1.58747565
50MP0001853_heart_inflammation1.58685899
51MP0002132_abnormal_respiratory_system1.58414757
52MP0004808_abnormal_hematopoietic_stem1.53649630
53MP0000490_abnormal_crypts_of1.52132351
54MP0010307_abnormal_tumor_latency1.51770443
55MP0008260_abnormal_autophagy1.51706096
56MP0000858_altered_metastatic_potential1.46861998
57MP0009379_abnormal_foot_pigmentation1.37284826
58MP0002006_tumorigenesis1.36923755
59MP0003448_altered_tumor_morphology1.36323911
60MP0003866_abnormal_defecation1.35462186
61MP0000343_altered_response_to1.35298990
62MP0002277_abnormal_respiratory_mucosa1.34173146
63MP0008469_abnormal_protein_level1.32763887
64MP0005076_abnormal_cell_differentiation1.30990859
65MP0005310_abnormal_salivary_gland1.30666233
66MP0000703_abnormal_thymus_morphology1.29215546
67MP0006054_spinal_hemorrhage1.25832329
68MP0003186_abnormal_redox_activity1.22848616
69MP0005084_abnormal_gallbladder_morpholo1.22063500
70MP0003075_altered_response_to1.21808580
71MP0003656_abnormal_erythrocyte_physiolo1.20962919
72MP0010234_abnormal_vibrissa_follicle1.15434013
73MP0004883_abnormal_blood_vessel1.15135039
74MP0003693_abnormal_embryo_hatching1.11429884
75MP0008004_abnormal_stomach_pH1.10911970
76MP0002877_abnormal_melanocyte_morpholog1.08232395
77MP0005023_abnormal_wound_healing1.07850443
78MP0005075_abnormal_melanosome_morpholog1.06563153
79MP0002933_joint_inflammation1.06267236
80MP0006036_abnormal_mitochondrial_physio0.98014440
81MP0005164_abnormal_response_to0.97786998
82MP0002019_abnormal_tumor_incidence0.97500542
83MP0002998_abnormal_bone_remodeling0.97111372
84MP0000604_amyloidosis0.96912440
85MP0003183_abnormal_peptide_metabolism0.94313949
86MP0005166_decreased_susceptibility_to0.94009210
87MP0009764_decreased_sensitivity_to0.93881940
88MP0003453_abnormal_keratinocyte_physiol0.91544444
89MP0000609_abnormal_liver_physiology0.90219022
90MP0001851_eye_inflammation0.89760077
91MP0001663_abnormal_digestive_system0.89438082
92MP0001542_abnormal_bone_strength0.84255879
93MP0005167_abnormal_blood-brain_barrier0.82921066
94MP0002136_abnormal_kidney_physiology0.79094693
95MP0005451_abnormal_body_composition0.78702928
96MP0002138_abnormal_hepatobiliary_system0.78622688
97MP0000249_abnormal_blood_vessel0.78554568
98MP0003045_fibrosis0.77631300
99MP0005083_abnormal_biliary_tract0.77163344
100MP0009765_abnormal_xenobiotic_induced0.74558498
101MP0005408_hypopigmentation0.74068076
102MP0002139_abnormal_hepatobiliary_system0.72737413
103MP0005165_increased_susceptibility_to0.69629054
104MP0003091_abnormal_cell_migration0.69366323
105MP0009763_increased_sensitivity_to0.69212632
106MP0005174_abnormal_tail_pigmentation0.68855702
107MP0003795_abnormal_bone_structure0.68547896
108MP0000598_abnormal_liver_morphology0.68280187
109MP0003077_abnormal_cell_cycle0.67497075
110MP0003828_pulmonary_edema0.67257533
111MP0000477_abnormal_intestine_morphology0.65668980
112MP0003252_abnormal_bile_duct0.64182265
113MP0005390_skeleton_phenotype0.63290892
114MP0005319_abnormal_enzyme/_coenzyme0.63273863
115MP0009643_abnormal_urine_homeostasis0.62527982
116MP0008873_increased_physiological_sensi0.62492744
117MP0001958_emphysema0.62136449
118MP0001764_abnormal_homeostasis0.61993521
119MP0005584_abnormal_enzyme/coenzyme_acti0.61851698
120MP0008961_abnormal_basal_metabolism0.60543719
121MP0002163_abnormal_gland_morphology0.59832570
122MP0002693_abnormal_pancreas_physiology0.59684203
123MP0008438_abnormal_cutaneous_collagen0.59677640
124MP0003786_premature_aging0.57919591
125MP0000372_irregular_coat_pigmentation0.57382681

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)4.51506532
2Recurrent abscess formation (HP:0002722)4.37230743
3Eczematoid dermatitis (HP:0000976)4.33714033
4Recurrent bacterial skin infections (HP:0005406)3.80761723
5Myositis (HP:0100614)3.71733998
6Elevated erythrocyte sedimentation rate (HP:0003565)3.49467868
7Cellulitis (HP:0100658)3.32334376
8Increased cerebral lipofuscin (HP:0011813)3.29473328
9IgM deficiency (HP:0002850)3.16839343
10Recurrent fungal infections (HP:0002841)3.16104687
11Recurrent viral infections (HP:0004429)3.15427846
12Recurrent gram-negative bacterial infections (HP:0005420)3.15401571
13Interstitial pulmonary disease (HP:0006530)3.15294010
14Increased IgM level (HP:0003496)3.10414922
15Abnormality of the nasal mucosa (HP:0000433)3.06964395
16Thrombocytosis (HP:0001894)3.06358479
17Nasal polyposis (HP:0100582)3.05958450
18Autoimmune thrombocytopenia (HP:0001973)3.01883300
19Systemic lupus erythematosus (HP:0002725)2.99430359
20Abnormality of macrophages (HP:0004311)2.98341303
21Mitochondrial inheritance (HP:0001427)2.96260008
22Encephalitis (HP:0002383)2.94803146
23Vacuolated lymphocytes (HP:0001922)2.86623678
24Recurrent bronchitis (HP:0002837)2.85978824
25Increased density of long bones (HP:0006392)2.85928709
26Orchitis (HP:0100796)2.85645617
27Dysostosis multiplex (HP:0000943)2.84511830
28Pustule (HP:0200039)2.83404717
29Acute necrotizing encephalopathy (HP:0006965)2.82772404
30Aplastic anemia (HP:0001915)2.81657799
31Mediastinal lymphadenopathy (HP:0100721)2.81398078
32Petechiae (HP:0000967)2.79626333
33Gastrointestinal inflammation (HP:0004386)2.73637223
34Inflammation of the large intestine (HP:0002037)2.70902087
35Decreased activity of mitochondrial respiratory chain (HP:0008972)2.69870651
36Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.69870651
373-Methylglutaconic aciduria (HP:0003535)2.69063690
38Hepatocellular necrosis (HP:0001404)2.69035663
39Spontaneous hematomas (HP:0007420)2.68522336
40Abnormal mitochondria in muscle tissue (HP:0008316)2.68469324
41Meningitis (HP:0001287)2.68081083
42Colitis (HP:0002583)2.66792304
43Papilloma (HP:0012740)2.64399950
44Verrucae (HP:0200043)2.64399950
45Impaired platelet aggregation (HP:0003540)2.63064316
46Abnormal platelet function (HP:0011869)2.63064316
47Chronic obstructive pulmonary disease (HP:0006510)2.62747893
48Obstructive lung disease (HP:0006536)2.62747893
49Urticaria (HP:0001025)2.62570427
50Mucopolysacchariduria (HP:0008155)2.59126773
51Urinary glycosaminoglycan excretion (HP:0003541)2.59126773
52Increased neuronal autofluorescent lipopigment (HP:0002074)2.58739941
53Renal Fanconi syndrome (HP:0001994)2.57115347
54Exertional dyspnea (HP:0002875)2.56687649
55Arterial thrombosis (HP:0004420)2.55801768
56Hematochezia (HP:0002573)2.52955833
57Increased CSF lactate (HP:0002490)2.52048276
58Vasculitis (HP:0002633)2.49874815
59Hepatosplenomegaly (HP:0001433)2.48805645
60Increased hepatocellular lipid droplets (HP:0006565)2.47742932
61Recurrent skin infections (HP:0001581)2.46004826
62Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.45832127
63Abnormal delayed hypersensitivity skin test (HP:0002963)2.44142709
64Abnormality of polysaccharide metabolism (HP:0011012)2.41828133
65Abnormality of glycosaminoglycan metabolism (HP:0004371)2.41828133
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.41828133
67Autoimmune hemolytic anemia (HP:0001890)2.40455599
68Progressive macrocephaly (HP:0004481)2.38221128
69Hepatic necrosis (HP:0002605)2.37263010
70Amyloidosis (HP:0011034)2.36324806
71Increased IgE level (HP:0003212)2.35668785
72Chronic diarrhea (HP:0002028)2.34887515
73Increased intramyocellular lipid droplets (HP:0012240)2.34766240
74Acute encephalopathy (HP:0006846)2.33997898
75Hypergammaglobulinemia (HP:0010702)2.29998595
76Lipid accumulation in hepatocytes (HP:0006561)2.29432363
77Skin rash (HP:0000988)2.28885859
78Osteomyelitis (HP:0002754)2.27700078
79Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.26753193
80Prolonged bleeding time (HP:0003010)2.26681285
81Respiratory difficulties (HP:0002880)2.26380426
82Abnormality of T cells (HP:0002843)2.24979605
83Lymphopenia (HP:0001888)2.24890538
84Retrobulbar optic neuritis (HP:0100654)2.24222939
85Optic neuritis (HP:0100653)2.24222939
86Abnormality of cells of the lymphoid lineage (HP:0012140)2.23389477
87Abnormality of the prostate (HP:0008775)2.22914302
88Abnormality of B cell number (HP:0010975)2.22904611
89Keratoconjunctivitis sicca (HP:0001097)2.22174097
90Abnormality of T cell physiology (HP:0011840)2.20859418
91Chest pain (HP:0100749)2.20762329
92Granulocytopenia (HP:0001913)2.18789637
93Bilateral sensorineural hearing impairment (HP:0008619)2.17767234
94Chronic sinusitis (HP:0011109)2.17485528
95Alopecia of scalp (HP:0002293)2.17223530
96Agammaglobulinemia (HP:0004432)2.15821093
97Abnormal platelet volume (HP:0011876)2.15528055
98Disinhibition (HP:0000734)2.15339025
99IgG deficiency (HP:0004315)2.14865453
100Increased serum ferritin (HP:0003281)2.14080957
101Gangrene (HP:0100758)2.13801136
102Anorexia (HP:0002039)2.13483733
103Fatigue (HP:0012378)2.11436569
104Progressive neurologic deterioration (HP:0002344)2.11388624
105Periodontitis (HP:0000704)2.10545140
106B lymphocytopenia (HP:0010976)2.08667286
107Epistaxis (HP:0000421)2.08413359
108Keratoconjunctivitis (HP:0001096)2.07928760
109Increased muscle lipid content (HP:0009058)2.07758257
110Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.07322596
111Skin ulcer (HP:0200042)2.06616229
112T lymphocytopenia (HP:0005403)2.05923485
113Abnormality of T cell number (HP:0011839)2.03147996
114Cheilitis (HP:0100825)2.03144520
115Purpura (HP:0000979)2.02363208
116Abnormality of glycolipid metabolism (HP:0010969)2.01933973
117Abnormality of liposaccharide metabolism (HP:0010968)2.01933973
118Abnormality of glycosphingolipid metabolism (HP:0004343)2.01933973
119Loss of speech (HP:0002371)2.01061387
120Recurrent cutaneous fungal infections (HP:0011370)2.00555779
121Chronic mucocutaneous candidiasis (HP:0002728)2.00555779
122Gingivitis (HP:0000230)2.00206716
123Panhypogammaglobulinemia (HP:0003139)1.99049546
124Gastrointestinal stroma tumor (HP:0100723)1.98997055
125Cerebral aneurysm (HP:0004944)1.98287132
126Pulmonary infiltrates (HP:0002113)1.95381857
127Polycythemia (HP:0001901)1.93592302
128Abnormality of the pleura (HP:0002103)1.93089045
129Severe combined immunodeficiency (HP:0004430)1.92961136
130Abnormality of iron homeostasis (HP:0011031)1.92382547
131Macrocytic anemia (HP:0001972)1.91411217
132Myocardial infarction (HP:0001658)1.91069049
133Emphysema (HP:0002097)1.90994586
134Gingival bleeding (HP:0000225)1.90850917
135Stomatitis (HP:0010280)1.90092115
136Cutaneous melanoma (HP:0012056)1.86650720
137Hemoptysis (HP:0002105)1.85662511
138Leukocytosis (HP:0001974)1.85051484
139Abnormality of cells of the erythroid lineage (HP:0012130)1.84443773
140Osteolytic defects of the phalanges of the hand (HP:0009771)1.83189894
141Osteolytic defects of the hand bones (HP:0009699)1.83189894
142Thoracic kyphosis (HP:0002942)1.81986205
143Gastrointestinal infarctions (HP:0005244)1.79909466
144Increased mean platelet volume (HP:0011877)1.78526990
145Eosinophilia (HP:0001880)1.77795049

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.01532688
2TRIB33.85693115
3PKN23.33009535
4ERN13.14523819
5EEF2K3.13046844
6LRRK22.30583584
7BMPR22.26518594
8TYK22.20474660
9TBK12.17077426
10BLK2.16288306
11MST42.09699809
12SCYL21.98759600
13VRK21.98242239
14KIT1.98148944
15ZAP701.90677639
16STK101.88477447
17MAP3K101.87985964
18GRK61.86569631
19SIK21.79265945
20PAK41.72631178
21NME21.71721493
22JAK31.59777076
23BTK1.54567738
24TESK21.53621699
25STK161.46098919
26TXK1.45371473
27SYK1.44130879
28SIK11.42555833
29CSF1R1.42490392
30TGFBR21.39948289
31TTN1.33797035
32KDR1.33331854
33MAP2K31.30187622
34JAK11.29248179
35PTK61.27530764
36FES1.22731741
37GRK71.21431987
38RPS6KA41.21396147
39PIM21.20566660
40CDK191.19459415
41CSK1.18410036
42EPHB11.17603909
43IKBKE1.16151559
44ITK1.16140295
45FGFR41.16132759
46MARK31.16036784
47HCK1.13617742
48TAOK31.11488257
49LIMK11.08986713
50ARAF1.06090925
51TEC1.05097652
52MAP3K111.04969517
53BCKDK1.04740522
54RIPK11.03691792
55ALK1.00834646
56SIK31.00760376
57PIM10.99115266
58TESK10.98191215
59BMX0.94658333
60MYLK0.94179658
61RPS6KB20.93548425
62TAOK20.93305009
63RIPK40.91238790
64FLT30.89347009
65NEK20.88726316
66JAK20.88612248
67MAP3K80.87154609
68MAPKAPK30.86689742
69IKBKB0.85100500
70LCK0.85058632
71MATK0.84601801
72MAP3K140.83922389
73LYN0.81800298
74IRAK40.80784927
75ILK0.77984223
76FGFR30.75686869
77ABL20.74672869
78TLK10.71835184
79EIF2AK30.70535638
80PRKCQ0.70319292
81KSR20.68632149
82TGFBR10.68269982
83TAOK10.66939856
84NEK10.65306540
85VRK10.63968376
86CDK40.63107453
87PDK20.62817160
88CAMKK10.62477549
89MAP3K120.62257143
90MAPK110.60509288
91MAP3K30.59328365
92MAP3K130.57870920
93CDK60.56529833
94RET0.54905433
95IRAK30.54404631
96PRKCH0.54013850
97MAP3K50.52626434
98PRPF4B0.51218921
99FGR0.51015247
100NEK90.50958001
101PIK3CG0.50952919
102PRKCD0.49248389
103PRKG20.46648967
104FYN0.44808767
105ACVR1B0.44024374
106PAK10.42693373
107RPS6KA60.42223433
108CAMK1D0.41855113
109EPHA20.41011995
110PASK0.40624060
111CHUK0.40173265
112ADRBK20.38287444
113MOS0.38205745
114MAP3K10.38064835
115PDK10.37945933
116MAPKAPK20.37822265
117ABL10.37628472
118MAPK40.37462273
119CAMKK20.36039201
120CLK10.36006986
121EGFR0.35901686
122RPS6KC10.35838298
123RPS6KL10.35838298
124DAPK30.33814411
125EIF2AK10.33550068
126MAP3K20.32807058
127SRPK10.31808977
128DAPK10.30590368
129TNK20.30522727
130CSNK2A10.30108714
131CDK120.30016980
132CSNK2A20.30016016
133IRAK10.28546423
134PRKCI0.25132520

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053203.18065131
2Proteasome_Homo sapiens_hsa030503.03295227
3Leishmaniasis_Homo sapiens_hsa051402.85499270
4Oxidative phosphorylation_Homo sapiens_hsa001902.83208182
5Type I diabetes mellitus_Homo sapiens_hsa049402.56513350
6Primary immunodeficiency_Homo sapiens_hsa053402.49468303
7B cell receptor signaling pathway_Homo sapiens_hsa046622.41861034
8Antigen processing and presentation_Homo sapiens_hsa046122.39723748
9Osteoclast differentiation_Homo sapiens_hsa043802.39256323
10Parkinsons disease_Homo sapiens_hsa050122.25557592
11Staphylococcus aureus infection_Homo sapiens_hsa051502.07874237
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.98406954
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.96067721
14* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.86347086
15Tuberculosis_Homo sapiens_hsa051521.83669084
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.83464570
17Measles_Homo sapiens_hsa051621.81481602
18Legionellosis_Homo sapiens_hsa051341.77805860
19Toxoplasmosis_Homo sapiens_hsa051451.76714641
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.75066199
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.74078690
22Pertussis_Homo sapiens_hsa051331.73696113
23Protein export_Homo sapiens_hsa030601.73342909
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.69796199
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.69559012
26Lysosome_Homo sapiens_hsa041421.62680362
27Apoptosis_Homo sapiens_hsa042101.60543438
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.55817874
29Chronic myeloid leukemia_Homo sapiens_hsa052201.55794466
30Hematopoietic cell lineage_Homo sapiens_hsa046401.55722445
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.53591924
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.50735610
33Alzheimers disease_Homo sapiens_hsa050101.49407500
34Other glycan degradation_Homo sapiens_hsa005111.44548842
35* Shigellosis_Homo sapiens_hsa051311.43953113
36T cell receptor signaling pathway_Homo sapiens_hsa046601.43339527
37Acute myeloid leukemia_Homo sapiens_hsa052211.42533598
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39152226
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37767430
40Hepatitis B_Homo sapiens_hsa051611.36416111
41Huntingtons disease_Homo sapiens_hsa050161.35525650
42* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.35102085
43Ribosome_Homo sapiens_hsa030101.30809604
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.27366171
45Influenza A_Homo sapiens_hsa051641.27177676
46TNF signaling pathway_Homo sapiens_hsa046681.25886872
47Malaria_Homo sapiens_hsa051441.25568851
48DNA replication_Homo sapiens_hsa030301.25244911
49Pancreatic cancer_Homo sapiens_hsa052121.24956254
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.24563072
51Pentose phosphate pathway_Homo sapiens_hsa000301.21254615
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.19804070
53Herpes simplex infection_Homo sapiens_hsa051681.18697644
54Viral myocarditis_Homo sapiens_hsa054161.16636160
55VEGF signaling pathway_Homo sapiens_hsa043701.15140365
56Caffeine metabolism_Homo sapiens_hsa002321.14409328
57NOD-like receptor signaling pathway_Homo sapiens_hsa046211.13447056
58Chemokine signaling pathway_Homo sapiens_hsa040621.11292043
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10818371
60Platelet activation_Homo sapiens_hsa046111.09789560
61Collecting duct acid secretion_Homo sapiens_hsa049661.08240889
62* Salmonella infection_Homo sapiens_hsa051321.06249284
63* Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06170879
64Neurotrophin signaling pathway_Homo sapiens_hsa047221.02484884
65Small cell lung cancer_Homo sapiens_hsa052221.00012455
66Non-small cell lung cancer_Homo sapiens_hsa052230.96881869
67Viral carcinogenesis_Homo sapiens_hsa052030.95835204
68HIF-1 signaling pathway_Homo sapiens_hsa040660.91635128
69Allograft rejection_Homo sapiens_hsa053300.86231242
70Phagosome_Homo sapiens_hsa041450.85807023
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85754241
72Amoebiasis_Homo sapiens_hsa051460.85468415
73Asthma_Homo sapiens_hsa053100.83179505
74Hepatitis C_Homo sapiens_hsa051600.82776629
75HTLV-I infection_Homo sapiens_hsa051660.82018087
76mTOR signaling pathway_Homo sapiens_hsa041500.81487575
77Colorectal cancer_Homo sapiens_hsa052100.79870926
78Epstein-Barr virus infection_Homo sapiens_hsa051690.79628716
79Prolactin signaling pathway_Homo sapiens_hsa049170.78464405
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71941676
81RNA polymerase_Homo sapiens_hsa030200.71061800
82p53 signaling pathway_Homo sapiens_hsa041150.69353531
83* Endocytosis_Homo sapiens_hsa041440.69214793
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68339797
85Graft-versus-host disease_Homo sapiens_hsa053320.67490752
86Sulfur metabolism_Homo sapiens_hsa009200.67366746
87African trypanosomiasis_Homo sapiens_hsa051430.66064950
88Glutathione metabolism_Homo sapiens_hsa004800.64482900
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63877319
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.62980974
91Insulin resistance_Homo sapiens_hsa049310.62090705
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61269115
93Pyrimidine metabolism_Homo sapiens_hsa002400.60419882
94Proteoglycans in cancer_Homo sapiens_hsa052050.59788758
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59096744
96Bladder cancer_Homo sapiens_hsa052190.58285428
97Vibrio cholerae infection_Homo sapiens_hsa051100.58253695
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55670934
99Renin-angiotensin system_Homo sapiens_hsa046140.55610008
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54848902
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54772356
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.52811726
103Base excision repair_Homo sapiens_hsa034100.52341934
104Renal cell carcinoma_Homo sapiens_hsa052110.51788349
105Glioma_Homo sapiens_hsa052140.51755003
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.51407085
107Spliceosome_Homo sapiens_hsa030400.51366509
108Rheumatoid arthritis_Homo sapiens_hsa053230.50101185
109N-Glycan biosynthesis_Homo sapiens_hsa005100.49661998
110Focal adhesion_Homo sapiens_hsa045100.48621891
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47513953
112* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47092909
113Systemic lupus erythematosus_Homo sapiens_hsa053220.46721757
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46447792
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44685720
116Thyroid cancer_Homo sapiens_hsa052160.42938738
117Endometrial cancer_Homo sapiens_hsa052130.42563215
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42426160
119Sulfur relay system_Homo sapiens_hsa041220.41591565
120MicroRNAs in cancer_Homo sapiens_hsa052060.40405014
121Notch signaling pathway_Homo sapiens_hsa043300.40383278
122Regulation of autophagy_Homo sapiens_hsa041400.40299462
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40071435
124FoxO signaling pathway_Homo sapiens_hsa040680.38730381
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.36956662
126Fatty acid elongation_Homo sapiens_hsa000620.36627083
127Galactose metabolism_Homo sapiens_hsa000520.34849499
128Nucleotide excision repair_Homo sapiens_hsa034200.32004335
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31742293
130Cardiac muscle contraction_Homo sapiens_hsa042600.30916806
131Homologous recombination_Homo sapiens_hsa034400.28972645
132Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.27683286
133Mismatch repair_Homo sapiens_hsa034300.24585857
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24547239
135Mineral absorption_Homo sapiens_hsa049780.21666436
136Peroxisome_Homo sapiens_hsa041460.20550601
137Arachidonic acid metabolism_Homo sapiens_hsa005900.19832911
138Folate biosynthesis_Homo sapiens_hsa007900.19336135

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