ARPC3P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of natural killer cell differentiation (GO:0032825)7.21343455
2behavioral response to nicotine (GO:0035095)5.81715756
3DNA deamination (GO:0045006)5.57223718
4endoderm formation (GO:0001706)5.49906583
5positive regulation of interleukin-17 production (GO:0032740)5.32035338
6tyrosine phosphorylation of STAT protein (GO:0007260)5.07871644
7cellular response to ATP (GO:0071318)5.07835195
8regulation of natural killer cell differentiation (GO:0032823)4.88579940
9response to pheromone (GO:0019236)4.75640445
10synaptic transmission, cholinergic (GO:0007271)4.74282527
11positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.55086734
12regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.54643017
13positive regulation of natural killer cell mediated immunity (GO:0002717)4.47558719
14protein neddylation (GO:0045116)4.45418527
15detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.35692350
16positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)4.16917904
17positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.15730678
18regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)4.13217521
19cellular response to interleukin-15 (GO:0071350)3.85738526
20response to interleukin-15 (GO:0070672)3.69574987
21cellular ketone body metabolic process (GO:0046950)3.68575020
22fucose catabolic process (GO:0019317)3.65917525
23L-fucose metabolic process (GO:0042354)3.65917525
24L-fucose catabolic process (GO:0042355)3.65917525
25negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.65384011
26negative regulation of translation, ncRNA-mediated (GO:0040033)3.65384011
27regulation of translation, ncRNA-mediated (GO:0045974)3.65384011
28positive regulation of interleukin-10 production (GO:0032733)3.61135131
29regulation of natural killer cell mediated immunity (GO:0002715)3.57881314
30regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.57881314
31mannosylation (GO:0097502)3.53144009
32positive regulation of antigen processing and presentation (GO:0002579)3.51821075
33ketone body metabolic process (GO:1902224)3.46797310
34positive regulation of natural killer cell activation (GO:0032816)3.46706801
35interferon-gamma production (GO:0032609)3.46378348
36protein K63-linked deubiquitination (GO:0070536)3.45770268
37necroptotic process (GO:0070266)3.31856068
38GTP biosynthetic process (GO:0006183)3.29466535
39CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.28557630
40positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.28455271
41seminiferous tubule development (GO:0072520)3.28106028
42regulation of isotype switching to IgG isotypes (GO:0048302)3.21234859
43coenzyme catabolic process (GO:0009109)3.20369496
44adaptation of signaling pathway (GO:0023058)3.18706774
45epithelial cilium movement (GO:0003351)3.18405404
46regulation of interferon-gamma biosynthetic process (GO:0045072)3.15662932
47cytidine deamination (GO:0009972)3.12709046
48cytidine metabolic process (GO:0046087)3.12709046
49cytidine catabolic process (GO:0006216)3.12709046
50epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.10268774
51positive regulation of T-helper 1 type immune response (GO:0002827)3.09664355
52activated T cell proliferation (GO:0050798)3.07962435
53ncRNA catabolic process (GO:0034661)3.07704534
54ovulation cycle (GO:0042698)3.06383454
55regulation of leukocyte mediated cytotoxicity (GO:0001910)3.05628716
56preassembly of GPI anchor in ER membrane (GO:0016254)3.05526852
57maturation of 5.8S rRNA (GO:0000460)3.04250415
58positive regulation of cell killing (GO:0031343)2.97049447
59regulation of natural killer cell activation (GO:0032814)2.94596102
60peptidyl-histidine modification (GO:0018202)2.93280325
61positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.92663017
62regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.92663017
63platelet dense granule organization (GO:0060155)2.90993577
64cytochrome complex assembly (GO:0017004)2.88933807
65alpha-beta T cell differentiation involved in immune response (GO:0002293)2.88628891
66alpha-beta T cell activation involved in immune response (GO:0002287)2.88628891
67T cell differentiation involved in immune response (GO:0002292)2.88628891
68cofactor catabolic process (GO:0051187)2.88353509
69regulation of vesicle fusion (GO:0031338)2.87425971
70regulation of cell killing (GO:0031341)2.83441377
71kidney morphogenesis (GO:0060993)2.82171795
72N-glycan processing (GO:0006491)2.82100698
73negative regulation of T cell differentiation in thymus (GO:0033085)2.80985455
74xenobiotic catabolic process (GO:0042178)2.77343728
75positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.76872421
76positive regulation of protein homooligomerization (GO:0032464)2.76578891
77positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.76069158
78regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.76069158
79activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.74069943
80regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.73863643
81somite development (GO:0061053)2.71770880
82isoprenoid biosynthetic process (GO:0008299)2.71276118
83negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.64440558
84negative regulation of T-helper cell differentiation (GO:0045623)2.64440558
85regulation of interleukin-10 production (GO:0032653)2.63655081
86regulation of mesoderm development (GO:2000380)2.62598023
87RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.62153483
88regulation of T-helper 1 type immune response (GO:0002825)2.60999483
89positive regulation of prostaglandin secretion (GO:0032308)2.60701994
90ATP synthesis coupled proton transport (GO:0015986)2.60243018
91energy coupled proton transport, down electrochemical gradient (GO:0015985)2.60243018
92pyrimidine ribonucleoside catabolic process (GO:0046133)2.60230337
93regulation of interleukin-17 production (GO:0032660)2.58097979
94negative regulation of telomere maintenance (GO:0032205)2.57810088
95regulation of posttranscriptional gene silencing (GO:0060147)2.56466745
96regulation of gene silencing by miRNA (GO:0060964)2.56466745
97regulation of gene silencing by RNA (GO:0060966)2.56466745
98positive regulation of vesicle fusion (GO:0031340)2.56214594
99negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.54886938
100protein complex biogenesis (GO:0070271)2.54135662

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.75736457
2ELF1_17652178_ChIP-ChIP_JURKAT_Human3.45052276
3ZNF274_21170338_ChIP-Seq_K562_Hela3.25671482
4VDR_22108803_ChIP-Seq_LS180_Human3.24477050
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.08504376
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.05655349
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.98791244
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.82742941
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.60279106
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.39062883
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.37086427
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19728814
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06831866
14EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.02857175
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94003386
16PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92261647
17GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.83414312
18PCGF2_27294783_Chip-Seq_NPCs_Mouse1.74745344
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.74099474
20IRF8_22096565_ChIP-ChIP_GC-B_Human1.71697193
21TP53_22573176_ChIP-Seq_HFKS_Human1.65921812
22MYC_18940864_ChIP-ChIP_HL60_Human1.62123924
23IGF1R_20145208_ChIP-Seq_DFB_Human1.60203404
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56931816
25AUTS2_25519132_ChIP-Seq_293T-REX_Human1.56240810
26ER_23166858_ChIP-Seq_MCF-7_Human1.54593122
27ELK1_19687146_ChIP-ChIP_HELA_Human1.53547651
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49338676
29FOXA1_27270436_Chip-Seq_PROSTATE_Human1.49315052
30FOXA1_25329375_ChIP-Seq_VCAP_Human1.49315052
31P300_19829295_ChIP-Seq_ESCs_Human1.49275989
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.48994354
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47162193
34EWS_26573619_Chip-Seq_HEK293_Human1.46543384
35FOXA1_21572438_ChIP-Seq_LNCaP_Human1.45820480
36AR_20517297_ChIP-Seq_VCAP_Human1.45757224
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42949190
38GATA3_21878914_ChIP-Seq_MCF-7_Human1.41313615
39VDR_23849224_ChIP-Seq_CD4+_Human1.35723244
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34982546
41TCF4_22108803_ChIP-Seq_LS180_Human1.33680838
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32820546
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32246652
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31763044
45NCOR_22424771_ChIP-Seq_293T_Human1.31222642
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30509271
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.29750692
48EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27423705
49TAF2_19829295_ChIP-Seq_ESCs_Human1.27282178
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26739130
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26458082
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.20915905
53GATA3_26560356_Chip-Seq_TH2_Human1.20685777
54SOX2_19829295_ChIP-Seq_ESCs_Human1.20666426
55NANOG_19829295_ChIP-Seq_ESCs_Human1.20666426
56CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.20033470
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17905311
58REST_21632747_ChIP-Seq_MESCs_Mouse1.16918235
59JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16897680
60TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.16001070
61ERA_21632823_ChIP-Seq_H3396_Human1.15222164
62FOXP3_21729870_ChIP-Seq_TREG_Human1.12915318
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.12714920
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12611853
65CBP_20019798_ChIP-Seq_JUKART_Human1.12611853
66BP1_19119308_ChIP-ChIP_Hs578T_Human1.12039385
67NANOG_20526341_ChIP-Seq_ESCs_Human1.11883840
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10741081
69HTT_18923047_ChIP-ChIP_STHdh_Human1.09990582
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.09795301
71IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08337953
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07447073
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.07043751
74STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.05747966
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05454807
76RBPJ_21746931_ChIP-Seq_IB4_Human1.05333830
77MYC_19829295_ChIP-Seq_ESCs_Human1.04997904
78GATA6_21074721_ChIP-Seq_CACO-2_Human1.04983832
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.04205457
80FOXH1_21741376_ChIP-Seq_ESCs_Human1.03068474
81HOXB7_26014856_ChIP-Seq_BT474_Human1.03040840
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02472373
83TAF15_26573619_Chip-Seq_HEK293_Human1.01978089
84NMYC_18555785_Chip-Seq_ESCs_Mouse1.00438207
85PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98747898
86PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96707983
87BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96006050
88FOXH1_21741376_ChIP-Seq_EPCs_Human0.95722198
89BCAT_22108803_ChIP-Seq_LS180_Human0.94365766
90KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93765161
91STAT3_23295773_ChIP-Seq_U87_Human0.93733139
92P53_22387025_ChIP-Seq_ESCs_Mouse0.93494647
93STAT3_18555785_Chip-Seq_ESCs_Mouse0.93491708
94P53_21459846_ChIP-Seq_SAOS-2_Human0.92346019
95GBX2_23144817_ChIP-Seq_PC3_Human0.91698471
96RNF2_27304074_Chip-Seq_NSC_Mouse0.91577000
97ETV1_20927104_ChIP-Seq_GIST48_Human0.91561063
98P300_18555785_Chip-Seq_ESCs_Mouse0.91297750
99EGR1_19032775_ChIP-ChIP_M12_Human0.90648115
100ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90550369

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001348_abnormal_lacrimal_gland3.88662373
2MP0000569_abnormal_digit_pigmentation3.69907218
3MP0003195_calcinosis3.60322049
4MP0003787_abnormal_imprinting3.33761869
5MP0003890_abnormal_embryonic-extraembry2.85974076
6MP0002102_abnormal_ear_morphology2.85125482
7MP0006072_abnormal_retinal_apoptosis2.82254859
8MP0000372_irregular_coat_pigmentation2.78435799
9MP0008877_abnormal_DNA_methylation2.67966024
10MP0004885_abnormal_endolymph2.63757572
11MP0004742_abnormal_vestibular_system2.62039877
12MP0002163_abnormal_gland_morphology2.47088732
13MP0002138_abnormal_hepatobiliary_system2.24853288
14MP0001873_stomach_inflammation2.21666166
15MP0005671_abnormal_response_to2.12602972
16MP0008872_abnormal_physiological_respon2.10383420
17MP0008875_abnormal_xenobiotic_pharmacok1.95601131
18MP0005083_abnormal_biliary_tract1.92438235
19MP0005253_abnormal_eye_physiology1.80818708
20MP0005084_abnormal_gallbladder_morpholo1.77957208
21MP0004142_abnormal_muscle_tone1.73070924
22MP0003121_genomic_imprinting1.69427394
23MP0001790_abnormal_immune_system1.64379393
24MP0005387_immune_system_phenotype1.64379393
25MP0002837_dystrophic_cardiac_calcinosis1.59573280
26MP0003567_abnormal_fetal_cardiomyocyte1.59178385
27MP0004147_increased_porphyrin_level1.56582151
28MP0002876_abnormal_thyroid_physiology1.55097158
29MP0006082_CNS_inflammation1.51782545
30MP0005408_hypopigmentation1.50610041
31MP0003879_abnormal_hair_cell1.47988881
32MP0009333_abnormal_splenocyte_physiolog1.44411439
33MP0005646_abnormal_pituitary_gland1.41528932
34MP0003136_yellow_coat_color1.39776772
35MP0005174_abnormal_tail_pigmentation1.36226041
36MP0001440_abnormal_grooming_behavior1.35547236
37MP0003315_abnormal_perineum_morphology1.35360434
38MP0005379_endocrine/exocrine_gland_phen1.33772590
39MP0001968_abnormal_touch/_nociception1.30048436
40MP0002736_abnormal_nociception_after1.29899399
41MP0005551_abnormal_eye_electrophysiolog1.27262317
42MP0003646_muscle_fatigue1.25731918
43MP0001986_abnormal_taste_sensitivity1.25720654
44MP0004043_abnormal_pH_regulation1.25472579
45MP0005075_abnormal_melanosome_morpholog1.19143454
46MP0003763_abnormal_thymus_physiology1.18839139
47MP0004381_abnormal_hair_follicle1.18326347
48MP0002166_altered_tumor_susceptibility1.16934073
49MP0003718_maternal_effect1.15404126
50MP0003122_maternal_imprinting1.14085692
51MP0003011_delayed_dark_adaptation1.12331980
52MP0005167_abnormal_blood-brain_barrier1.11713147
53MP0000613_abnormal_salivary_gland1.10122519
54MP0005310_abnormal_salivary_gland1.09399648
55MP0001800_abnormal_humoral_immune1.07579472
56MP0001485_abnormal_pinna_reflex1.07033649
57MP0002234_abnormal_pharynx_morphology1.06012439
58MP0002272_abnormal_nervous_system1.01401175
59MP0003943_abnormal_hepatobiliary_system1.01129971
60MP0001324_abnormal_eye_pigmentation1.00242968
61MP0005187_abnormal_penis_morphology1.00069548
62MP0000685_abnormal_immune_system0.99551047
63MP0002184_abnormal_innervation0.98696613
64MP0006276_abnormal_autonomic_nervous0.96151211
65MP0009046_muscle_twitch0.95967903
66MP0004145_abnormal_muscle_electrophysio0.95966846
67MP0002877_abnormal_melanocyte_morpholog0.95641486
68MP0002723_abnormal_immune_serum0.93083240
69MP0008995_early_reproductive_senescence0.91361829
70MP0001835_abnormal_antigen_presentation0.91242319
71MP0003123_paternal_imprinting0.90385137
72MP0000015_abnormal_ear_pigmentation0.88996023
73MP0002006_tumorigenesis0.88490590
74MP0002735_abnormal_chemical_nociception0.87460686
75MP0009745_abnormal_behavioral_response0.86826882
76MP0002148_abnormal_hypersensitivity_rea0.86471552
77MP0002638_abnormal_pupillary_reflex0.86058825
78MP0002095_abnormal_skin_pigmentation0.85426213
79MP0002132_abnormal_respiratory_system0.84517803
80MP0001984_abnormal_olfaction0.82861555
81MP0003866_abnormal_defecation0.82454160
82MP0002928_abnormal_bile_duct0.79924619
83MP0008789_abnormal_olfactory_epithelium0.79003251
84MP0002452_abnormal_antigen_presenting0.77637947
85MP0001529_abnormal_vocalization0.76524224
86MP0000778_abnormal_nervous_system0.75978709
87MP0002420_abnormal_adaptive_immunity0.74874992
88MP0001919_abnormal_reproductive_system0.74767250
89MP0010155_abnormal_intestine_physiology0.71760569
90MP0005000_abnormal_immune_tolerance0.71442789
91MP0000470_abnormal_stomach_morphology0.71230269
92MP0001819_abnormal_immune_cell0.70968882
93MP0002557_abnormal_social/conspecific_i0.70769753
94MP0002254_reproductive_system_inflammat0.70071125
95MP0003300_gastrointestinal_ulcer0.69629566
96MP0009785_altered_susceptibility_to0.68905299
97MP0005636_abnormal_mineral_homeostasis0.66505701
98MP0005195_abnormal_posterior_eye0.66162269
99MP0006054_spinal_hemorrhage0.65969868
100MP0002938_white_spotting0.65549850

Predicted human phenotypes

RankGene SetZ-score
1Chronic diarrhea (HP:0002028)4.34201222
2Pancreatic fibrosis (HP:0100732)3.87963290
3Hypoproteinemia (HP:0003075)3.87848775
4Pancreatic cysts (HP:0001737)3.83807486
5Papilledema (HP:0001085)3.70430121
6True hermaphroditism (HP:0010459)3.35560592
7Abnormality of the renal cortex (HP:0011035)3.24211515
8Congenital stationary night blindness (HP:0007642)3.21793488
9Degeneration of the lateral corticospinal tracts (HP:0002314)2.97655460
10Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.97655460
11Abnormal delayed hypersensitivity skin test (HP:0002963)2.92558625
12Stomatitis (HP:0010280)2.88330189
13Chronic hepatic failure (HP:0100626)2.86870009
14Molar tooth sign on MRI (HP:0002419)2.86370143
15Abnormality of midbrain morphology (HP:0002418)2.86370143
16Acute necrotizing encephalopathy (HP:0006965)2.80961409
17Abnormality of the corticospinal tract (HP:0002492)2.78845714
18Spinal muscular atrophy (HP:0007269)2.78517045
19Nephronophthisis (HP:0000090)2.75965189
20Abnormality of the renal medulla (HP:0100957)2.74355284
21Renal cortical cysts (HP:0000803)2.70172595
22Exotropia (HP:0000577)2.69805542
23Methylmalonic aciduria (HP:0012120)2.66284480
24Increased corneal curvature (HP:0100692)2.66037846
25Keratoconus (HP:0000563)2.66037846
26Decreased central vision (HP:0007663)2.63337773
27Abnormality of T cell number (HP:0011839)2.59262844
28Methylmalonic acidemia (HP:0002912)2.56273103
29Abnormal mitochondria in muscle tissue (HP:0008316)2.54765957
30Cystic liver disease (HP:0006706)2.52016233
31Decreased electroretinogram (ERG) amplitude (HP:0000654)2.50688495
32Adrenal hypoplasia (HP:0000835)2.48197697
33Tubular atrophy (HP:0000092)2.47153380
34Abnormal drinking behavior (HP:0030082)2.40241349
35Polydipsia (HP:0001959)2.40241349
36Mitochondrial inheritance (HP:0001427)2.39619214
37Progressive macrocephaly (HP:0004481)2.38673728
38Aplasia/Hypoplasia of the spleen (HP:0010451)2.38141914
39Concave nail (HP:0001598)2.35214554
40Respiratory difficulties (HP:0002880)2.32602076
41Asplenia (HP:0001746)2.31843382
42Genetic anticipation (HP:0003743)2.27483114
43Abnormality of DNA repair (HP:0003254)2.27113706
44Increased CSF lactate (HP:0002490)2.26541053
45Acute encephalopathy (HP:0006846)2.23876347
46Attenuation of retinal blood vessels (HP:0007843)2.20211691
473-Methylglutaconic aciduria (HP:0003535)2.17438943
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.16127290
49Decreased activity of mitochondrial respiratory chain (HP:0008972)2.16127290
50Bile duct proliferation (HP:0001408)2.15085480
51Abnormal biliary tract physiology (HP:0012439)2.15085480
52Abolished electroretinogram (ERG) (HP:0000550)2.13941688
53Progressive inability to walk (HP:0002505)2.13889850
54Type I transferrin isoform profile (HP:0003642)2.12874627
55Polyuria (HP:0000103)2.08596627
56Optic disc pallor (HP:0000543)2.06145734
57Increased IgM level (HP:0003496)2.05992973
58Polyphagia (HP:0002591)2.02723468
59Abnormality of aspartate family amino acid metabolism (HP:0010899)2.02535342
60Enlarged kidneys (HP:0000105)2.02326893
61Hypophosphatemic rickets (HP:0004912)1.99922513
62Abnormality of eosinophils (HP:0001879)1.98531542
63Lissencephaly (HP:0001339)1.97610295
64Abnormality of the pons (HP:0007361)1.96264252
65Urinary bladder sphincter dysfunction (HP:0002839)1.95634561
66Hypoplasia of the pons (HP:0012110)1.94229836
67Type II lissencephaly (HP:0007260)1.94167851
68Congenital hepatic fibrosis (HP:0002612)1.92724153
69IgG deficiency (HP:0004315)1.92199414
70Lipid accumulation in hepatocytes (HP:0006561)1.89895200
71T lymphocytopenia (HP:0005403)1.89656713
72Aplasia/Hypoplasia of the uvula (HP:0010293)1.89442009
73Chronic bronchitis (HP:0004469)1.88752294
74Shawl scrotum (HP:0000049)1.88017263
75Pancreatic islet-cell hyperplasia (HP:0004510)1.87992597
76Limb dystonia (HP:0002451)1.87715188
77Inability to walk (HP:0002540)1.87674740
78Oligomenorrhea (HP:0000876)1.87647838
79Reduced antithrombin III activity (HP:0001976)1.87538185
80Hepatocellular necrosis (HP:0001404)1.87334512
81Brushfield spots (HP:0001088)1.87214256
82Degeneration of anterior horn cells (HP:0002398)1.87108013
83Abnormality of the anterior horn cell (HP:0006802)1.87108013
84Abnormality of abdominal situs (HP:0011620)1.81997569
85Abdominal situs inversus (HP:0003363)1.81997569
86Abnormal protein glycosylation (HP:0012346)1.81611246
87Abnormal glycosylation (HP:0012345)1.81611246
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.81611246
89Abnormal protein N-linked glycosylation (HP:0012347)1.81611246
90Increased hepatocellular lipid droplets (HP:0006565)1.81427783
91Pendular nystagmus (HP:0012043)1.81102679
92Thyroiditis (HP:0100646)1.80994867
93Absent speech (HP:0001344)1.80896661
94Congenital, generalized hypertrichosis (HP:0004540)1.80396575
95Gonadotropin excess (HP:0000837)1.80177412
96Autoimmune hemolytic anemia (HP:0001890)1.78727695
97Abnormality of the renal collecting system (HP:0004742)1.78564038
98Dynein arm defect of respiratory motile cilia (HP:0012255)1.76937449
99Absent/shortened dynein arms (HP:0200106)1.76937449
100Type 2 muscle fiber atrophy (HP:0003554)1.76829493

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.56412397
2CAMKK23.39051160
3FRK3.04711923
4EPHB22.91792110
5WNK42.45769173
6OXSR12.35009566
7PAK32.27846670
8ADRBK22.25180999
9PDK22.21968321
10NUAK12.21146323
11BCR2.20494233
12TLK12.15410983
13TIE12.12921408
14DYRK1B2.12282505
15NME12.06544529
16GRK12.02213281
17EIF2AK31.81335969
18WNK31.67202230
19TSSK61.60962015
20PINK11.51470496
21IKBKB1.49730953
22PAK61.49486455
23MUSK1.41701425
24FES1.35359395
25TRIM281.33530321
26ITK1.29906015
27CAMKK11.29408195
28TGFBR21.25471991
29ACVR1B1.24867964
30PTK61.24255946
31MAP3K121.23567017
32MAP3K131.22960216
33MAPK131.22032528
34IKBKE1.21328341
35BMPR1B1.09934344
36PRKAA21.07943007
37CSNK1G21.06298516
38MAP3K141.05829200
39CLK11.03610222
40NEK11.01500340
41CDK191.00538936
42MST41.00009214
43PHKG21.00004104
44PHKG11.00004104
45PRKCZ0.96281625
46VRK20.95705979
47MAPKAPK30.95174953
48NTRK20.94004574
49DAPK20.90309248
50STK110.87575465
51DYRK20.86569877
52TAOK30.84605632
53PRKCE0.81134331
54JAK30.81090986
55KSR10.79416889
56FER0.78862154
57BCKDK0.76623001
58CSNK1G30.76169006
59PLK20.75515768
60PRKCQ0.75065490
61PRKCI0.74399374
62ZAK0.72895117
63PLK40.72660605
64MAP2K60.72589998
65CSNK1G10.72237950
66IRAK10.69613300
67ADRBK10.69418411
68SGK10.68334454
69NTRK10.68004401
70PLK30.65917449
71MINK10.65213395
72MKNK20.63452513
73TEC0.63419690
74CSNK1A1L0.61128246
75NEK20.58910373
76PRKCG0.58382884
77STK160.55268422
78TGFBR10.54733253
79STK390.54282018
80MARK30.52728119
81SYK0.52722749
82RAF10.51793723
83LYN0.51725109
84CHUK0.51333943
85CSNK1A10.48765554
86VRK10.46494777
87EIF2AK20.45988481
88PRKACA0.44892983
89GRK50.44004161
90STK30.43984970
91TNK20.43754511
92CAMK1D0.41146504
93BTK0.40506520
94LCK0.39731451
95DYRK1A0.38150049
96PRKCH0.36155978
97PRKG10.35680545
98CSNK1D0.35603313
99INSRR0.35578212
100PRKCB0.33501634

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.27961527
2Oxidative phosphorylation_Homo sapiens_hsa001902.78378511
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.49426510
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.41066422
5Parkinsons disease_Homo sapiens_hsa050122.33779900
6Phototransduction_Homo sapiens_hsa047442.28599405
7Proteasome_Homo sapiens_hsa030502.19723164
8Linoleic acid metabolism_Homo sapiens_hsa005912.16489902
9Dorso-ventral axis formation_Homo sapiens_hsa043202.11847383
10Nitrogen metabolism_Homo sapiens_hsa009102.09918199
11Primary immunodeficiency_Homo sapiens_hsa053402.08050704
12Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.99597789
13Butanoate metabolism_Homo sapiens_hsa006501.93128324
14Peroxisome_Homo sapiens_hsa041461.87810798
15Autoimmune thyroid disease_Homo sapiens_hsa053201.86820939
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.74144514
17Ether lipid metabolism_Homo sapiens_hsa005651.73809882
18Allograft rejection_Homo sapiens_hsa053301.71534060
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.69923514
20N-Glycan biosynthesis_Homo sapiens_hsa005101.63606577
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50500128
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47238937
23Protein export_Homo sapiens_hsa030601.46345332
24Alzheimers disease_Homo sapiens_hsa050101.40435283
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37685248
26Homologous recombination_Homo sapiens_hsa034401.36502218
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.36239208
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36000238
29Tryptophan metabolism_Homo sapiens_hsa003801.32805658
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32351297
31Hematopoietic cell lineage_Homo sapiens_hsa046401.31771347
32Graft-versus-host disease_Homo sapiens_hsa053321.31609176
33Caffeine metabolism_Homo sapiens_hsa002321.29170843
34Collecting duct acid secretion_Homo sapiens_hsa049661.28002444
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.27396625
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.26765257
37RNA degradation_Homo sapiens_hsa030181.24633933
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.22811519
39Cardiac muscle contraction_Homo sapiens_hsa042601.19128884
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17408016
41RNA polymerase_Homo sapiens_hsa030201.17181717
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16867254
43Huntingtons disease_Homo sapiens_hsa050161.15561277
44Rheumatoid arthritis_Homo sapiens_hsa053231.11442224
45Asthma_Homo sapiens_hsa053101.11066436
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10869856
47Propanoate metabolism_Homo sapiens_hsa006401.10294952
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.08622752
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05832593
50Fatty acid elongation_Homo sapiens_hsa000621.02737843
51NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99364492
52Type I diabetes mellitus_Homo sapiens_hsa049400.98535116
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.98443222
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98255163
55Fanconi anemia pathway_Homo sapiens_hsa034600.97718169
56RNA transport_Homo sapiens_hsa030130.96645945
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.96210702
58Chemical carcinogenesis_Homo sapiens_hsa052040.95499168
59Histidine metabolism_Homo sapiens_hsa003400.95031988
60Insulin secretion_Homo sapiens_hsa049110.92597474
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92577751
62beta-Alanine metabolism_Homo sapiens_hsa004100.90604123
63Mineral absorption_Homo sapiens_hsa049780.90370517
64T cell receptor signaling pathway_Homo sapiens_hsa046600.89592588
65Ribosome_Homo sapiens_hsa030100.87118336
66Antigen processing and presentation_Homo sapiens_hsa046120.85626384
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84385987
68Glycerolipid metabolism_Homo sapiens_hsa005610.80162470
69Ovarian steroidogenesis_Homo sapiens_hsa049130.78303502
70Arachidonic acid metabolism_Homo sapiens_hsa005900.76517602
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75331240
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74851447
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72933465
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70328994
75Retinol metabolism_Homo sapiens_hsa008300.69777037
76Metabolic pathways_Homo sapiens_hsa011000.66421873
77Steroid biosynthesis_Homo sapiens_hsa001000.63840519
78Vitamin digestion and absorption_Homo sapiens_hsa049770.61809631
79Olfactory transduction_Homo sapiens_hsa047400.58314937
80Basal transcription factors_Homo sapiens_hsa030220.57517062
81Synaptic vesicle cycle_Homo sapiens_hsa047210.56035514
82Nicotine addiction_Homo sapiens_hsa050330.54683020
83Thyroid hormone synthesis_Homo sapiens_hsa049180.52236537
84Purine metabolism_Homo sapiens_hsa002300.50569464
85Measles_Homo sapiens_hsa051620.50080653
86Fat digestion and absorption_Homo sapiens_hsa049750.47779749
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.45981595
88Oxytocin signaling pathway_Homo sapiens_hsa049210.40147939
89Serotonergic synapse_Homo sapiens_hsa047260.38404020
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37632054
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37459288
92Morphine addiction_Homo sapiens_hsa050320.37406902
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34829925
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32757968
95Regulation of autophagy_Homo sapiens_hsa041400.32175340
96One carbon pool by folate_Homo sapiens_hsa006700.32084342
97Starch and sucrose metabolism_Homo sapiens_hsa005000.30993976
98Glutathione metabolism_Homo sapiens_hsa004800.27279638
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.26146516
100ABC transporters_Homo sapiens_hsa020100.25789365

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