ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.55337419
2	DNA deamination (GO:0045006)	5.53509171
3	cytidine catabolic process (GO:0006216)	5.45666993
4	cytidine deamination (GO:0009972)	5.45666993
5	cytidine metabolic process (GO:0046087)	5.45666993
6	ATP synthesis coupled proton transport (GO:0015986)	5.41963703
7	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.41963703
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.18978718
9	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.82611168
10	negative regulation of mast cell activation (GO:0033004)	4.78806878
11	interferon-gamma production (GO:0032609)	4.54400114
12	protein neddylation (GO:0045116)	4.05030620
13	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.91560709
14	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.83356761
15	termination of RNA polymerase III transcription (GO:0006386)	3.78599495
16	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.78599495
17	respiratory electron transport chain (GO:0022904)	3.75659187
18	GTP biosynthetic process (GO:0006183)	3.71557058
19	behavioral response to nicotine (GO:0035095)	3.70417264
20	electron transport chain (GO:0022900)	3.69932106
21	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.66665995
22	chaperone-mediated protein transport (GO:0072321)	3.58813328
23	positive regulation of monocyte chemotaxis (GO:0090026)	3.57225584
24	purine deoxyribonucleotide catabolic process (GO:0009155)	3.47555611
25	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.38624523
26	protein K11-linked deubiquitination (GO:0035871)	3.37880600
27	cellular response to interleukin-15 (GO:0071350)	3.34479821
28	regulation of regulatory T cell differentiation (GO:0045589)	3.32928708
29	tyrosine phosphorylation of STAT protein (GO:0007260)	3.32230941
30	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.28032638
31	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.28032638
32	regulation of chronic inflammatory response (GO:0002676)	3.24474985
33	actin nucleation (GO:0045010)	3.18337012
34	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.18237865
35	hydrogen ion transmembrane transport (GO:1902600)	3.16273702
36	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.15452291
37	iron-sulfur cluster assembly (GO:0016226)	3.07436594
38	metallo-sulfur cluster assembly (GO:0031163)	3.07436594
39	piRNA metabolic process (GO:0034587)	3.07057072
40	proton transport (GO:0015992)	3.03873343
41	ATP biosynthetic process (GO:0006754)	3.01400225
42	preassembly of GPI anchor in ER membrane (GO:0016254)	3.00991742
43	UTP biosynthetic process (GO:0006228)	2.98794997
44	hydrogen transport (GO:0006818)	2.96882730
45	GPI anchor metabolic process (GO:0006505)	2.94565634
46	T cell costimulation (GO:0031295)	2.94502248
47	eosinophil chemotaxis (GO:0048245)	2.94053554
48	platelet dense granule organization (GO:0060155)	2.93818530
49	sequestering of actin monomers (GO:0042989)	2.92316347
50	positive regulation of calcium-mediated signaling (GO:0050850)	2.91455498
51	lymphocyte costimulation (GO:0031294)	2.91371015
52	protein localization to cilium (GO:0061512)	2.91107435
53	GPI anchor biosynthetic process (GO:0006506)	2.87495539
54	regulation of cellular amino acid metabolic process (GO:0006521)	2.84850217
55	positive regulation of prostaglandin secretion (GO:0032308)	2.84039941
56	positive regulation of mast cell degranulation (GO:0043306)	2.82486814
57	positive regulation of mast cell activation involved in immune response (GO:0033008)	2.82486814
58	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.81234908
59	protein-cofactor linkage (GO:0018065)	2.80928990
60	protein complex biogenesis (GO:0070271)	2.79743644
61	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.78730783
62	base-excision repair, AP site formation (GO:0006285)	2.78566169
63	regulation of T cell receptor signaling pathway (GO:0050856)	2.75256210
64	UTP metabolic process (GO:0046051)	2.74722598
65	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.73721624
66	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.72815204
67	response to interleukin-15 (GO:0070672)	2.71388821
68	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.67927572
69	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.66713811
70	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.66713811
71	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.66713811
72	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.64709063
73	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.64709063
74	eosinophil migration (GO:0072677)	2.64519744
75	activated T cell proliferation (GO:0050798)	2.64194408
76	negative regulation of T cell apoptotic process (GO:0070233)	2.63364256
77	negative regulation by host of viral transcription (GO:0043922)	2.63300785
78	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.62377440
79	regulation of action potential (GO:0098900)	2.62063142
80	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.61967217
81	serotonin receptor signaling pathway (GO:0007210)	2.61932526
82	CTP metabolic process (GO:0046036)	2.61738360
83	CTP biosynthetic process (GO:0006241)	2.61738360
84	respiratory chain complex IV assembly (GO:0008535)	2.61351905
85	purine deoxyribonucleotide metabolic process (GO:0009151)	2.60601596
86	positive regulation of fatty acid transport (GO:2000193)	2.57602598
87	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.55589022
88	NADH dehydrogenase complex assembly (GO:0010257)	2.55589022
89	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.55589022
90	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.55101322
91	negative regulation of B cell apoptotic process (GO:0002903)	2.53819676
92	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.53151989
93	regulation of T cell chemotaxis (GO:0010819)	2.52798575
94	positive regulation of T cell chemotaxis (GO:0010820)	2.52798575
95	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.49061540
96	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.49061540
97	positive regulation of mast cell activation (GO:0033005)	2.47799886
98	arginine metabolic process (GO:0006525)	2.47758383
99	signal peptide processing (GO:0006465)	2.46717291
100	peroxisome fission (GO:0016559)	2.46520542

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	5.14916591
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.07000294
3	VDR_22108803_ChIP-Seq_LS180_Human	3.02530806
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.66341929
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.53580630
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.50805305
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.42653547
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.31937451
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.31470808
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.24558934
11	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.00509989
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.00108261
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.96401160
14	ZNF274_21170338_ChIP-Seq_K562_Hela	1.95017559
15	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.89443444
16	VDR_23849224_ChIP-Seq_CD4+_Human	1.86988414
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.85052653
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.82862761
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.82313119
20	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.76697739
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.75410659
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.73797916
23	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.72669966
24	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.71038717
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.70391705
26	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.69458017
27	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.63566413
28	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.59289882
29	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.57882656
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.57534369
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.56149285
32	GBX2_23144817_ChIP-Seq_PC3_Human	1.55356228
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.50825093
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.50674577
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.50411948
36	TAF2_19829295_ChIP-Seq_ESCs_Human	1.47912258
37	EWS_26573619_Chip-Seq_HEK293_Human	1.44339422
38	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.42905525
39	FOXP3_21729870_ChIP-Seq_TREG_Human	1.38307361
40	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.38262541
41	MYC_18940864_ChIP-ChIP_HL60_Human	1.37484419
42	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.35645834
43	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.33443285
44	NCOR_22424771_ChIP-Seq_293T_Human	1.32745774
45	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31308774
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31308774
47	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.30758613
48	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.29097192
49	IGF1R_20145208_ChIP-Seq_DFB_Human	1.27723447
50	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.27377231
51	AR_20517297_ChIP-Seq_VCAP_Human	1.27082995
52	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26633743
53	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25434846
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25434846
55	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.25209115
56	GATA3_26560356_Chip-Seq_TH2_Human	1.23202155
57	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.21774092
58	P300_19829295_ChIP-Seq_ESCs_Human	1.21683264
59	IRF1_19129219_ChIP-ChIP_H3396_Human	1.21231338
60	TAF15_26573619_Chip-Seq_HEK293_Human	1.20886533
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.20866084
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.19499738
63	ER_23166858_ChIP-Seq_MCF-7_Human	1.17663550
64	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.17641758
65	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.17021617
66	STAT1_20625510_ChIP-Seq_HELA_Human	1.16913240
67	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.15597392
68	FUS_26573619_Chip-Seq_HEK293_Human	1.14293142
69	MYC_19829295_ChIP-Seq_ESCs_Human	1.13946627
70	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.13673430
71	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.12969467
72	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.09871964
73	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.09259408
74	CBP_20019798_ChIP-Seq_JUKART_Human	1.08216502
75	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.08216502
76	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08010965
77	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05459044
78	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05131520
79	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.03617714
80	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.02623735
81	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.01221803
82	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99617764
83	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.99047424
84	ERG_20517297_ChIP-Seq_VCAP_Human	0.98615905
85	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.98009017
86	ERA_21632823_ChIP-Seq_H3396_Human	0.97312116
87	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.97015180
88	BCAT_22108803_ChIP-Seq_LS180_Human	0.96670819
89	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.96140929
90	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.93830680
91	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.92317426
92	HOXB7_26014856_ChIP-Seq_BT474_Human	0.92152218
93	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.91371821
94	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.91058608
95	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.90822823
96	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.89667560
97	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.87588991
98	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.87329991
99	GATA3_27048872_Chip-Seq_THYMUS_Human	0.87301198
100	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.87221164

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.19296162
2	MP0002138_abnormal_hepatobiliary_system	2.89943846
3	MP0003646_muscle_fatigue	2.83625214
4	MP0001835_abnormal_antigen_presentation	2.70443754
5	MP0005645_abnormal_hypothalamus_physiol	2.35417804
6	MP0002837_dystrophic_cardiac_calcinosis	2.32678492
7	MP0001986_abnormal_taste_sensitivity	2.14396706
8	MP0004043_abnormal_pH_regulation	2.13283254
9	MP0004147_increased_porphyrin_level	2.07301223
10	MP0001968_abnormal_touch/_nociception	2.03059871
11	MP0008877_abnormal_DNA_methylation	1.99473467
12	MP0003806_abnormal_nucleotide_metabolis	1.98400381
13	MP0000685_abnormal_immune_system	1.94276528
14	MP0009333_abnormal_splenocyte_physiolog	1.93093901
15	MP0002006_tumorigenesis	1.89670408
16	MP0002148_abnormal_hypersensitivity_rea	1.87295037
17	MP0002638_abnormal_pupillary_reflex	1.87026242
18	MP0008875_abnormal_xenobiotic_pharmacok	1.86257053
19	MP0009785_altered_susceptibility_to	1.80702837
20	MP0006072_abnormal_retinal_apoptosis	1.79749105
21	MP0001919_abnormal_reproductive_system	1.77590054
22	MP0001984_abnormal_olfaction	1.75851170
23	MP0005084_abnormal_gallbladder_morpholo	1.70969529
24	MP0003718_maternal_effect	1.67801625
25	MP0006082_CNS_inflammation	1.65000662
26	MP0004145_abnormal_muscle_electrophysio	1.63936475
27	MP0006292_abnormal_olfactory_placode	1.63468708
28	MP0008872_abnormal_physiological_respon	1.56847120
29	MP0009379_abnormal_foot_pigmentation	1.56522185
30	MP0005551_abnormal_eye_electrophysiolog	1.55654889
31	MP0005646_abnormal_pituitary_gland	1.50461383
32	MP0005389_reproductive_system_phenotype	1.50437050
33	MP0001800_abnormal_humoral_immune	1.49331626
34	MP0009745_abnormal_behavioral_response	1.45340720
35	MP0006276_abnormal_autonomic_nervous	1.44658748
36	MP0001905_abnormal_dopamine_level	1.42266313
37	MP0002163_abnormal_gland_morphology	1.37582575
38	MP0008789_abnormal_olfactory_epithelium	1.37520476
39	MP0005000_abnormal_immune_tolerance	1.37311019
40	MP0001873_stomach_inflammation	1.36584997
41	MP0002736_abnormal_nociception_after	1.35933445
42	MP0005083_abnormal_biliary_tract	1.34778257
43	MP0001970_abnormal_pain_threshold	1.33568398
44	MP0001501_abnormal_sleep_pattern	1.33148701
45	MP0002723_abnormal_immune_serum	1.28831583
46	MP0001790_abnormal_immune_system	1.28040118
47	MP0005387_immune_system_phenotype	1.28040118
48	MP0000613_abnormal_salivary_gland	1.24379516
49	MP0003880_abnormal_central_pattern	1.22101194
50	MP0009764_decreased_sensitivity_to	1.21667505
51	MP0002876_abnormal_thyroid_physiology	1.19611204
52	MP0001819_abnormal_immune_cell	1.18688050
53	MP0002452_abnormal_antigen_presenting	1.17978262
54	MP0005310_abnormal_salivary_gland	1.17195050
55	MP0002272_abnormal_nervous_system	1.16793707
56	MP0002166_altered_tumor_susceptibility	1.16763833
57	MP0002733_abnormal_thermal_nociception	1.15967487
58	MP0003786_premature_aging	1.15641771
59	MP0002735_abnormal_chemical_nociception	1.15432821
60	MP0003787_abnormal_imprinting	1.13349956
61	MP0004142_abnormal_muscle_tone	1.13248677
62	MP0002420_abnormal_adaptive_immunity	1.13137152
63	MP0003763_abnormal_thymus_physiology	1.11678405
64	MP0002909_abnormal_adrenal_gland	1.10053987
65	MP0009046_muscle_twitch	1.03431525
66	MP0000569_abnormal_digit_pigmentation	1.03169935
67	MP0002405_respiratory_system_inflammati	1.02759588
68	MP0005332_abnormal_amino_acid	0.97796820
69	MP0005025_abnormal_response_to	0.97542832
70	MP0003638_abnormal_response/metabolism_	0.97497412
71	MP0003866_abnormal_defecation	0.96844040
72	MP0001845_abnormal_inflammatory_respons	0.96807867
73	MP0005379_endocrine/exocrine_gland_phen	0.95608737
74	MP0002234_abnormal_pharynx_morphology	0.95578045
75	MP0005394_taste/olfaction_phenotype	0.95346809
76	MP0005499_abnormal_olfactory_system	0.95346809
77	MP0003186_abnormal_redox_activity	0.95144475
78	MP0005670_abnormal_white_adipose	0.93489266
79	MP0002572_abnormal_emotion/affect_behav	0.93327665
80	MP0006036_abnormal_mitochondrial_physio	0.92211180
81	MP0005075_abnormal_melanosome_morpholog	0.90386387
82	MP0001853_heart_inflammation	0.88574166
83	MP0000372_irregular_coat_pigmentation	0.88388218
84	MP0008469_abnormal_protein_level	0.86541726
85	MP0001502_abnormal_circadian_rhythm	0.85339784
86	MP0010155_abnormal_intestine_physiology	0.84784366
87	MP0009643_abnormal_urine_homeostasis	0.83061253
88	MP0005253_abnormal_eye_physiology	0.82672936
89	MP0000230_abnormal_systemic_arterial	0.82601902
90	MP0002064_seizures	0.82513749
91	MP0003195_calcinosis	0.80214450
92	MP0002693_abnormal_pancreas_physiology	0.80155832
93	MP0008995_early_reproductive_senescence	0.78793969
94	MP0000716_abnormal_immune_system	0.78051488
95	MP0005636_abnormal_mineral_homeostasis	0.76728399
96	MP0003724_increased_susceptibility_to	0.75852289
97	MP0003011_delayed_dark_adaptation	0.75605339
98	MP0005174_abnormal_tail_pigmentation	0.73779365
99	MP0002210_abnormal_sex_determination	0.73694419
100	MP0002095_abnormal_skin_pigmentation	0.73180589

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.89809923
2	Pancreatic cysts (HP:0001737)	3.57892682
3	Hypoproteinemia (HP:0003075)	3.56384969
4	Mitochondrial inheritance (HP:0001427)	3.52716277
5	Abnormality of midbrain morphology (HP:0002418)	3.49016099
6	Molar tooth sign on MRI (HP:0002419)	3.49016099
7	Pancreatic fibrosis (HP:0100732)	3.48019209
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.40900966
9	Progressive macrocephaly (HP:0004481)	3.38993808
10	Congenital stationary night blindness (HP:0007642)	3.35387104
11	Acute encephalopathy (HP:0006846)	3.30437661
12	3-Methylglutaconic aciduria (HP:0003535)	3.27970979
13	IgG deficiency (HP:0004315)	3.24181536
14	Hepatocellular necrosis (HP:0001404)	3.22429072
15	Increased CSF lactate (HP:0002490)	3.16992024
16	True hermaphroditism (HP:0010459)	3.03335983
17	Recurrent cutaneous fungal infections (HP:0011370)	2.99989022
18	Chronic mucocutaneous candidiasis (HP:0002728)	2.99989022
19	Stomatitis (HP:0010280)	2.95645063
20	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.93457601
21	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.93457601
22	Hemoptysis (HP:0002105)	2.90219374
23	Congenital, generalized hypertrichosis (HP:0004540)	2.84709291
24	Chronic diarrhea (HP:0002028)	2.79314407
25	Abnormality of the prostate (HP:0008775)	2.77759243
26	Hepatic necrosis (HP:0002605)	2.74829341
27	Microretrognathia (HP:0000308)	2.62447407
28	Generalized aminoaciduria (HP:0002909)	2.60536224
29	Increased hepatocellular lipid droplets (HP:0006565)	2.57958564
30	Thyroiditis (HP:0100646)	2.57802791
31	Severe combined immunodeficiency (HP:0004430)	2.55123945
32	Elevated erythrocyte sedimentation rate (HP:0003565)	2.52931596
33	Abolished electroretinogram (ERG) (HP:0000550)	2.45147544
34	Constricted visual fields (HP:0001133)	2.45019246
35	Lipid accumulation in hepatocytes (HP:0006561)	2.43594057
36	Anencephaly (HP:0002323)	2.43078380
37	Renal Fanconi syndrome (HP:0001994)	2.42495302
38	Cystic liver disease (HP:0006706)	2.41749150
39	Abnormal rod and cone electroretinograms (HP:0008323)	2.37567543
40	Abnormality of T cell number (HP:0011839)	2.31155640
41	Optic disc pallor (HP:0000543)	2.29994896
42	Aplastic anemia (HP:0001915)	2.27186088
43	Nephronophthisis (HP:0000090)	2.25941726
44	Lissencephaly (HP:0001339)	2.21696731
45	Cerebral edema (HP:0002181)	2.21457232
46	Increased intramyocellular lipid droplets (HP:0012240)	2.19426440
47	Increased serum lactate (HP:0002151)	2.19192087
48	Chronic obstructive pulmonary disease (HP:0006510)	2.18385619
49	Obstructive lung disease (HP:0006536)	2.18385619
50	Agitation (HP:0000713)	2.16614925
51	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.16442407
52	Lactic acidosis (HP:0003128)	2.14309059
53	Alveolar cell carcinoma (HP:0006519)	2.13444638
54	Hypoalbuminemia (HP:0003073)	2.12860058
55	Abnormal albumin level (HP:0012116)	2.12860058
56	T lymphocytopenia (HP:0005403)	2.10166123
57	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.09371645
58	Pendular nystagmus (HP:0012043)	2.06960900
59	Renal cortical cysts (HP:0000803)	2.06295246
60	Tubulointerstitial nephritis (HP:0001970)	2.03483991
61	Exertional dyspnea (HP:0002875)	2.02120795
62	Pancytopenia (HP:0001876)	2.00882838
63	Fair hair (HP:0002286)	2.00680808
64	Increased IgM level (HP:0003496)	1.99582922
65	Abnormality of T cells (HP:0002843)	1.95048612
66	Opisthotonus (HP:0002179)	1.94551970
67	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.93595100
68	Glycosuria (HP:0003076)	1.92629196
69	Abnormality of urine glucose concentration (HP:0011016)	1.92629196
70	Absent/shortened dynein arms (HP:0200106)	1.92062157
71	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.92062157
72	Type II lissencephaly (HP:0007260)	1.91888893
73	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.91350342
74	Bifid tongue (HP:0010297)	1.90111976
75	Pachygyria (HP:0001302)	1.89260035
76	Cerebral palsy (HP:0100021)	1.89164225
77	Male pseudohermaphroditism (HP:0000037)	1.87843699
78	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.87290456
79	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.85685247
80	Cerebral hypomyelination (HP:0006808)	1.84983315
81	Attenuation of retinal blood vessels (HP:0007843)	1.84466507
82	Bile duct proliferation (HP:0001408)	1.83902305
83	Abnormal biliary tract physiology (HP:0012439)	1.83902305
84	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.83405517
85	Hypoplasia of the brainstem (HP:0002365)	1.83405517
86	Abnormal drinking behavior (HP:0030082)	1.82735458
87	Polydipsia (HP:0001959)	1.82735458
88	Combined immunodeficiency (HP:0005387)	1.80567828
89	Postaxial foot polydactyly (HP:0001830)	1.79641585
90	Abnormality of the labia minora (HP:0012880)	1.76994515
91	Abnormality of the pleura (HP:0002103)	1.76641665
92	Increased muscle lipid content (HP:0009058)	1.76183565
93	Lethargy (HP:0001254)	1.75835010
94	Sclerocornea (HP:0000647)	1.75398699
95	Cleft eyelid (HP:0000625)	1.74689931
96	Dyschromatopsia (HP:0007641)	1.73259703
97	Meningitis (HP:0001287)	1.72779022
98	Gangrene (HP:0100758)	1.71224554
99	Hypothermia (HP:0002045)	1.70343811
100	Ureteral stenosis (HP:0000071)	1.70284648

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.86271724
2	FRK	3.49876815
3	GRK1	3.36857785
4	MAP3K12	3.07158971
5	NUAK1	2.74487435
6	TLK1	2.60889968
7	ADRBK2	2.47639857
8	CDK19	2.37184138
9	KDR	2.13632496
10	BMPR2	2.13246210
11	NTRK2	2.04576169
12	ZAK	2.03553496
13	FES	1.94572565
14	WNK3	1.88191910
15	PINK1	1.85946616
16	TAOK3	1.84854295
17	WNK4	1.79266647
18	OXSR1	1.78899589
19	MAP4K2	1.77003118
20	BUB1	1.72973640
21	NTRK1	1.56679592
22	MST4	1.40974451
23	ITK	1.39683802
24	BCKDK	1.36825652
25	MYLK	1.36139181
26	MAPKAPK3	1.23801802
27	STK16	1.21571581
28	PRKCQ	1.18254625
29	BRSK1	1.14853578
30	TIE1	1.11203065
31	MAP3K13	1.09932369
32	IKBKB	1.09652619
33	LIMK1	1.03003220
34	PIK3CA	1.02066124
35	AURKA	0.99540941
36	STK39	0.98693216
37	INSRR	0.98611000
38	CSNK1G2	0.96043748
39	MUSK	0.92539969
40	NEK1	0.91360895
41	DYRK2	0.88707796
42	TSSK6	0.84632042
43	MINK1	0.81065276
44	GRK6	0.80964415
45	PRKCG	0.80589607
46	PDK2	0.77900464
47	TEC	0.77632138
48	UHMK1	0.76623800
49	EPHB2	0.72433891
50	BMPR1B	0.72230253
51	PRKCH	0.69967371
52	JAK3	0.68066263
53	PLK1	0.67949448
54	LCK	0.67870638
55	SYK	0.67827277
56	TESK2	0.67789049
57	KIT	0.67345938
58	VRK1	0.66215467
59	MARK3	0.63686394
60	PLK3	0.62872069
61	SIK3	0.62672296
62	OBSCN	0.61251758
63	ADRBK1	0.60354595
64	DAPK1	0.60344852
65	NME2	0.58171205
66	LYN	0.54228693
67	PRKACA	0.52473363
68	VRK2	0.51959712
69	GRK7	0.50906501
70	IKBKE	0.49474967
71	BTK	0.49445958
72	MAPKAPK5	0.49322718
73	CSNK1G3	0.49233458
74	CAMK2A	0.49027864
75	PRKCA	0.48876671
76	PLK2	0.47546296
77	CSK	0.47277485
78	PRKD3	0.45963077
79	ROCK1	0.45180008
80	CSF1R	0.41460641
81	PRKCZ	0.40171585
82	CSNK2A2	0.39038379
83	MAPK11	0.38960963
84	TAF1	0.38294610
85	NME1	0.37615139
86	IGF1R	0.36661592
87	CSNK2A1	0.36155094
88	PRKCI	0.35934899
89	PRKG1	0.35452095
90	MAP2K6	0.35403541
91	STK11	0.33993490
92	ERBB3	0.32808550
93	SIK2	0.32471130
94	MAPK13	0.32424816
95	AURKB	0.32022734
96	TYRO3	0.30934627
97	PRKCE	0.30361178
98	ERBB2	0.29531067
99	CSNK1G1	0.29527178
100	RPS6KA5	0.28296466

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.36131718
2	Graft-versus-host disease_Homo sapiens_hsa05332	4.01168529
3	Allograft rejection_Homo sapiens_hsa05330	3.68925172
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.61935374
5	Oxidative phosphorylation_Homo sapiens_hsa00190	3.40766416
6	Type I diabetes mellitus_Homo sapiens_hsa04940	3.25655635
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.15314993
8	Proteasome_Homo sapiens_hsa03050	3.12150304
9	Parkinsons disease_Homo sapiens_hsa05012	2.73939453
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.23566121
11	RNA polymerase_Homo sapiens_hsa03020	2.22383791
12	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.17298066
13	Antigen processing and presentation_Homo sapiens_hsa04612	2.16589296
14	Primary immunodeficiency_Homo sapiens_hsa05340	2.05516391
15	Protein export_Homo sapiens_hsa03060	2.03892077
16	Rheumatoid arthritis_Homo sapiens_hsa05323	1.89708897
17	Viral myocarditis_Homo sapiens_hsa05416	1.81963890
18	Huntingtons disease_Homo sapiens_hsa05016	1.74656814
19	Alzheimers disease_Homo sapiens_hsa05010	1.74502802
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.68069846
21	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.62317782
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.51651258
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.47543037
24	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.41246580
25	Phototransduction_Homo sapiens_hsa04744	1.38171360
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.35788087
27	Ribosome_Homo sapiens_hsa03010	1.31927412
28	Sulfur relay system_Homo sapiens_hsa04122	1.25142843
29	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.19432350
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.05448565
31	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.00598650
32	Basal transcription factors_Homo sapiens_hsa03022	1.00256964
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.00169877
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.99326642
35	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.97416209
36	Regulation of autophagy_Homo sapiens_hsa04140	0.96210765
37	Nitrogen metabolism_Homo sapiens_hsa00910	0.94300794
38	Nicotine addiction_Homo sapiens_hsa05033	0.93415235
39	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.92834442
40	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.92384738
41	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.91835142
42	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.85363252
43	Peroxisome_Homo sapiens_hsa04146	0.83393601
44	Pyrimidine metabolism_Homo sapiens_hsa00240	0.77718623
45	RNA degradation_Homo sapiens_hsa03018	0.77611579
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.74939051
47	Propanoate metabolism_Homo sapiens_hsa00640	0.70360732
48	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.70107332
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.67753065
50	Leishmaniasis_Homo sapiens_hsa05140	0.67290260
51	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.66771751
52	Morphine addiction_Homo sapiens_hsa05032	0.65640024
53	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.62785964
54	Homologous recombination_Homo sapiens_hsa03440	0.57725543
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.56197188
56	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.56154760
57	Purine metabolism_Homo sapiens_hsa00230	0.54528193
58	Tryptophan metabolism_Homo sapiens_hsa00380	0.53612960
59	Butanoate metabolism_Homo sapiens_hsa00650	0.52851952
60	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.52190697
61	One carbon pool by folate_Homo sapiens_hsa00670	0.51457861
62	GABAergic synapse_Homo sapiens_hsa04727	0.50900101
63	Phagosome_Homo sapiens_hsa04145	0.49942662
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.49748882
65	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.48272370
66	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.47837126
67	Ether lipid metabolism_Homo sapiens_hsa00565	0.44263377
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.43955128
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.43901703
70	Fanconi anemia pathway_Homo sapiens_hsa03460	0.43729119
71	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.40403925
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.38994658
73	Retinol metabolism_Homo sapiens_hsa00830	0.38616577
74	Olfactory transduction_Homo sapiens_hsa04740	0.38080761
75	Metabolic pathways_Homo sapiens_hsa01100	0.36515635
76	Fat digestion and absorption_Homo sapiens_hsa04975	0.35565987
77	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.34267514
78	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.34233703
79	Non-homologous end-joining_Homo sapiens_hsa03450	0.33813524
80	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.33362915
81	Glutathione metabolism_Homo sapiens_hsa00480	0.32651765
82	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.31656304
83	RNA transport_Homo sapiens_hsa03013	0.31447104
84	Serotonergic synapse_Homo sapiens_hsa04726	0.30862425
85	Sulfur metabolism_Homo sapiens_hsa00920	0.30032084
86	Herpes simplex infection_Homo sapiens_hsa05168	0.29346932
87	Salivary secretion_Homo sapiens_hsa04970	0.29001362
88	Base excision repair_Homo sapiens_hsa03410	0.28771433
89	Folate biosynthesis_Homo sapiens_hsa00790	0.26638870
90	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.25896352
91	Salmonella infection_Homo sapiens_hsa05132	0.25600202
92	Chemokine signaling pathway_Homo sapiens_hsa04062	0.24368239
93	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.23854844
94	Nucleotide excision repair_Homo sapiens_hsa03420	0.23253914
95	Caffeine metabolism_Homo sapiens_hsa00232	0.22665541
96	Taste transduction_Homo sapiens_hsa04742	0.22644326
97	Fatty acid degradation_Homo sapiens_hsa00071	0.21883768
98	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.21102906
99	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.20874564
100	Pyruvate metabolism_Homo sapiens_hsa00620	0.20796760

ARPC3P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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