ARPC4-TTLL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring ARPC4 (actin related protein 2/3 complex, subunit 4) and TTLL3 (tubulin tyrosine ligase-like family, member 3) genes. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.30398139
2regulation of B cell receptor signaling pathway (GO:0050855)4.99250158
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.93784499
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.93784499
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.93784499
6modulation by symbiont of host immune response (GO:0052553)4.93784499
7positive regulation by symbiont of host defense response (GO:0052509)4.93784499
8modulation by symbiont of host defense response (GO:0052031)4.93784499
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.57324569
10negative regulation of cell killing (GO:0031342)4.57324569
11positive regulation of B cell differentiation (GO:0045579)4.26884137
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.26378508
13regulation of gamma-delta T cell activation (GO:0046643)4.25898589
14antigen processing and presentation of endogenous antigen (GO:0019883)4.18031358
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.08558129
16response to peptidoglycan (GO:0032494)4.07984992
17negative thymic T cell selection (GO:0045060)4.03154739
18detection of other organism (GO:0098543)4.03121858
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.02793364
20positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.01664874
21B cell receptor signaling pathway (GO:0050853)3.98255681
22cellular extravasation (GO:0045123)3.95439343
23neutrophil activation involved in immune response (GO:0002283)3.91410812
24regulation of gamma-delta T cell differentiation (GO:0045586)3.90656611
25immunoglobulin mediated immune response (GO:0016064)3.89346117
26detection of bacterium (GO:0016045)3.86969207
27negative T cell selection (GO:0043383)3.85243561
28response to interleukin-15 (GO:0070672)3.80964646
29macrophage activation involved in immune response (GO:0002281)3.79810434
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.70606180
31leukocyte aggregation (GO:0070486)3.67783290
32response to muramyl dipeptide (GO:0032495)3.65716277
33regulation of interferon-beta biosynthetic process (GO:0045357)3.61839592
34T cell migration (GO:0072678)3.61440376
35regulation of B cell differentiation (GO:0045577)3.58616253
36negative regulation of interleukin-12 production (GO:0032695)3.52403465
37positive thymic T cell selection (GO:0045059)3.47947482
38positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.43671394
39negative regulation of erythrocyte differentiation (GO:0045647)3.43548041
40response to host immune response (GO:0052572)3.41912493
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.41912493
42detection of external biotic stimulus (GO:0098581)3.40749899
43respiratory burst (GO:0045730)3.36325108
44detection of molecule of bacterial origin (GO:0032490)3.35112133
45negative regulation of lymphocyte mediated immunity (GO:0002707)3.34322956
46cellular response to interleukin-15 (GO:0071350)3.29761221
47germinal center formation (GO:0002467)3.29257262
48neutrophil activation (GO:0042119)3.22091416
49* Arp2/3 complex-mediated actin nucleation (GO:0034314)3.21433352
503-UTR-mediated mRNA stabilization (GO:0070935)3.19182948
51positive regulation of granulocyte differentiation (GO:0030854)3.18850390
52neutrophil mediated immunity (GO:0002446)3.18689982
53response to host (GO:0075136)3.15978751
54response to host defenses (GO:0052200)3.15978751
55response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.15978751
56regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.14107198
57positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.13468527
58spliceosomal tri-snRNP complex assembly (GO:0000244)3.13373765
59thymic T cell selection (GO:0045061)3.12156305
60negative regulation of T cell mediated immunity (GO:0002710)3.08002915
61B cell mediated immunity (GO:0019724)3.06991296
62T cell selection (GO:0045058)3.05264089
63myeloid cell activation involved in immune response (GO:0002275)3.04206877
64negative regulation of leukocyte mediated immunity (GO:0002704)3.03182445
65regulation of RNA export from nucleus (GO:0046831)3.02654105
66positive T cell selection (GO:0043368)3.00256621
67hemidesmosome assembly (GO:0031581)2.99954794
68regulation of mast cell degranulation (GO:0043304)2.99801013
69granulocyte activation (GO:0036230)2.97396154
70detection of biotic stimulus (GO:0009595)2.95924171
71regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.94650602
72type I interferon signaling pathway (GO:0060337)2.91447704
73cellular response to type I interferon (GO:0071357)2.91447704
74regulation of alpha-beta T cell proliferation (GO:0046640)2.87065560
75response to type I interferon (GO:0034340)2.86087293
76tolerance induction (GO:0002507)2.84017275
77microglial cell activation (GO:0001774)2.83513868
78regulation of interferon-beta production (GO:0032648)2.83009778
79antigen processing and presentation via MHC class Ib (GO:0002475)2.82950423
80positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.82585732
81pinocytosis (GO:0006907)2.79355847
82regulation of T cell tolerance induction (GO:0002664)2.76090898
83regulation of type I interferon-mediated signaling pathway (GO:0060338)2.75291907
84negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.74456068
85macrophage activation (GO:0042116)2.74347568
86T-helper 1 type immune response (GO:0042088)2.73503663
87lipopolysaccharide-mediated signaling pathway (GO:0031663)2.73370401
88regulation of mast cell activation involved in immune response (GO:0033006)2.73031006
89regulation of nucleobase-containing compound transport (GO:0032239)2.70335751
90myeloid leukocyte mediated immunity (GO:0002444)2.69772621
91interferon-gamma-mediated signaling pathway (GO:0060333)2.69598155
92regulation of T-helper 2 cell differentiation (GO:0045628)2.69443595
93regulation of myeloid leukocyte mediated immunity (GO:0002886)2.69339527
94defense response to protozoan (GO:0042832)2.68549878
95negative regulation of glycoprotein biosynthetic process (GO:0010561)2.67509929
96regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.65180218
97regulation of natural killer cell mediated immunity (GO:0002715)2.63933855
98regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.63933855
99regulation of tolerance induction (GO:0002643)2.63474775
100NIK/NF-kappaB signaling (GO:0038061)2.62383715

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.51789835
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.61967053
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.49249166
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.12001187
5MYC_22102868_ChIP-Seq_BL_Human3.11282274
6SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.04616754
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.89926524
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83141529
9VDR_21846776_ChIP-Seq_THP-1_Human2.75020726
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.73777143
11SPI1_23547873_ChIP-Seq_NB4_Human2.68093656
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.63413564
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.62697921
14SPI1_23127762_ChIP-Seq_K562_Human2.58016050
15MAF_26560356_Chip-Seq_TH1_Human2.57617612
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.55293510
17MYB_26560356_Chip-Seq_TH2_Human2.52987429
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.52440129
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.46960978
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.39009360
21MYB_26560356_Chip-Seq_TH1_Human2.38310313
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30304414
23VDR_24763502_ChIP-Seq_THP-1_Human2.29871145
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.24529956
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.24393590
26UTX_26944678_Chip-Seq_JUKART_Human2.20179177
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18489107
28RUNX_20019798_ChIP-Seq_JUKART_Human2.17785015
29SCL_19346495_ChIP-Seq_HPC-7_Human2.14755121
30RUNX1_22412390_ChIP-Seq_EML_Mouse2.13601073
31CIITA_25753668_ChIP-Seq_RAJI_Human2.12550686
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.07981425
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.07529545
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06884207
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.06508219
36BRD4_27068464_Chip-Seq_AML-cells_Mouse2.02308139
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.97882825
38MAF_26560356_Chip-Seq_TH2_Human1.94745265
39TCF7_22412390_ChIP-Seq_EML_Mouse1.89532164
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.89519794
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.88505260
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.88181883
43TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.85743012
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79589244
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76345463
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70095113
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.66421821
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.61818477
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.59626086
50KDM2B_26808549_Chip-Seq_DND41_Human1.58559334
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.54347209
52NCOR1_26117541_ChIP-Seq_K562_Human1.53505698
53GATA3_27048872_Chip-Seq_THYMUS_Human1.53100160
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52471557
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52216523
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.51786223
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48996840
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.47243488
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42231901
60GATA1_19941826_ChIP-Seq_K562_Human1.41462043
61EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.39029226
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35440375
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31951751
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.30891589
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25259128
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22966406
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21491060
68TFEB_21752829_ChIP-Seq_HELA_Human1.19974407
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19850001
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19152388
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18668794
72ELF1_20517297_ChIP-Seq_JURKAT_Human1.18375514
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15855272
74RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15307816
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15179660
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12669258
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12094873
78CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10546367
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09518586
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.09375863
81GATA2_19941826_ChIP-Seq_K562_Human1.08631364
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07682605
83GATA3_26560356_Chip-Seq_TH2_Human1.03579831
84PU_27001747_Chip-Seq_BMDM_Mouse1.02336769
85LXR_22292898_ChIP-Seq_THP-1_Human1.01672218
86GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01187045
87E2F7_22180533_ChIP-Seq_HELA_Human1.00449960
88PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98514878
89GATA1_22025678_ChIP-Seq_K562_Human0.98208365
90PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97807196
91VDR_24787735_ChIP-Seq_THP-1_Human0.96077877
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94988243
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94440710
94RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93265621
95CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91298565
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90069162
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89077963
98FOXM1_23109430_ChIP-Seq_U2OS_Human0.88465247
99BCOR_27268052_Chip-Seq_Bcells_Human0.88087867
100GATA2_21666600_ChIP-Seq_HMVEC_Human0.87098842

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.63534917
2MP0003436_decreased_susceptibility_to3.44747082
3MP0005451_abnormal_body_composition3.01277057
4MP0005671_abnormal_response_to2.96451481
5MP0001800_abnormal_humoral_immune2.86302032
6MP0003303_peritoneal_inflammation2.83553023
7MP0002419_abnormal_innate_immunity2.73823449
8MP0000685_abnormal_immune_system2.68731110
9MP0003724_increased_susceptibility_to2.67154424
10MP0003763_abnormal_thymus_physiology2.62807043
11MP0005000_abnormal_immune_tolerance2.61250717
12MP0005025_abnormal_response_to2.54222497
13MP0008260_abnormal_autophagy2.52963734
14MP0002452_abnormal_antigen_presenting2.49793370
15MP0002723_abnormal_immune_serum2.48740050
16MP0002420_abnormal_adaptive_immunity2.47245622
17MP0001790_abnormal_immune_system2.42401347
18MP0005387_immune_system_phenotype2.42401347
19MP0001819_abnormal_immune_cell2.42311220
20MP0009785_altered_susceptibility_to2.21411443
21MP0002398_abnormal_bone_marrow2.20489362
22MP0005464_abnormal_platelet_physiology2.14562254
23MP0003300_gastrointestinal_ulcer2.12835267
24MP0000716_abnormal_immune_system1.97037941
25MP0009278_abnormal_bone_marrow1.91379840
26MP0002009_preneoplasia1.91225988
27MP0002332_abnormal_exercise_endurance1.90333765
28MP0002405_respiratory_system_inflammati1.84795552
29MP0003828_pulmonary_edema1.83732023
30MP0003172_abnormal_lysosome_physiology1.82621252
31MP0002396_abnormal_hematopoietic_system1.80868519
32MP0002722_abnormal_immune_system1.80701098
33MP0000689_abnormal_spleen_morphology1.78816646
34MP0002166_altered_tumor_susceptibility1.72355378
35MP0002148_abnormal_hypersensitivity_rea1.67673926
36MP0004947_skin_inflammation1.64810376
37MP0002429_abnormal_blood_cell1.64298369
38MP0000703_abnormal_thymus_morphology1.62710884
39MP0006082_CNS_inflammation1.62364661
40MP0003091_abnormal_cell_migration1.59620541
41MP0005058_abnormal_lysosome_morphology1.58081970
42MP0001845_abnormal_inflammatory_respons1.51842710
43MP0000858_altered_metastatic_potential1.51602614
44MP0003221_abnormal_cardiomyocyte_apopto1.50700468
45MP0003045_fibrosis1.47588233
46MP0003656_abnormal_erythrocyte_physiolo1.44067722
47MP0009333_abnormal_splenocyte_physiolog1.43716484
48MP0002132_abnormal_respiratory_system1.43711105
49MP0005397_hematopoietic_system_phenotyp1.40777752
50MP0001545_abnormal_hematopoietic_system1.40777752
51MP0000751_myopathy1.40566641
52MP0001533_abnormal_skeleton_physiology1.39827791
53MP0010155_abnormal_intestine_physiology1.39113402
54MP0006035_abnormal_mitochondrial_morpho1.38632522
55MP0003866_abnormal_defecation1.37553631
56MP0000465_gastrointestinal_hemorrhage1.31248970
57MP0001853_heart_inflammation1.29890370
58MP0002269_muscular_atrophy1.23233742
59MP0002006_tumorigenesis1.21258978
60MP0008469_abnormal_protein_level1.17821413
61MP0003191_abnormal_cellular_cholesterol1.16347503
62MP0005310_abnormal_salivary_gland1.14636857
63MP0004808_abnormal_hematopoietic_stem1.09652471
64MP0000749_muscle_degeneration1.07162797
65MP0005076_abnormal_cell_differentiation1.04937185
66MP0005023_abnormal_wound_healing1.01375214
67MP0009763_increased_sensitivity_to0.99930217
68MP0003183_abnormal_peptide_metabolism0.97618131
69MP0001851_eye_inflammation0.96197556
70MP0002019_abnormal_tumor_incidence0.96182406
71MP0004883_abnormal_blood_vessel0.94895278
72MP0000015_abnormal_ear_pigmentation0.93437384
73MP0004510_myositis0.93197890
74MP0003448_altered_tumor_morphology0.92827747
75MP0005621_abnormal_cell_physiology0.92430791
76MP0009764_decreased_sensitivity_to0.90194023
77MP0000358_abnormal_cell_content/0.88143641
78MP0000569_abnormal_digit_pigmentation0.85962950
79MP0002998_abnormal_bone_remodeling0.85124564
80MP0001873_stomach_inflammation0.79192929
81MP0000604_amyloidosis0.74502478
82MP0003075_altered_response_to0.73520510
83MP0003111_abnormal_nucleus_morphology0.72854920
84MP0009840_abnormal_foam_cell0.72567817
85MP0005384_cellular_phenotype0.72478567
86MP0008007_abnormal_cellular_replicative0.71607234
87MP0000313_abnormal_cell_death0.71369394
88MP0001915_intracranial_hemorrhage0.70267501
89MP0000343_altered_response_to0.69727408
90MP0003566_abnormal_cell_adhesion0.69410032
91MP0010630_abnormal_cardiac_muscle0.68843524
92MP0005164_abnormal_response_to0.67318260
93MP0005266_abnormal_metabolism0.65703996
94MP0006054_spinal_hemorrhage0.65238171
95MP0001243_abnormal_dermal_layer0.64557879
96MP0010094_abnormal_chromosome_stability0.64309676
97MP0004087_abnormal_muscle_fiber0.63515191
98MP0000249_abnormal_blood_vessel0.61665563
99MP0003795_abnormal_bone_structure0.61602155
100MP0004084_abnormal_cardiac_muscle0.61262806

Predicted human phenotypes

RankGene SetZ-score
1Increased connective tissue (HP:0009025)5.17714792
2Eczematoid dermatitis (HP:0000976)4.86242118
3Recurrent bacterial skin infections (HP:0005406)4.75469714
4Urethral obstruction (HP:0000796)4.73825411
5Recurrent abscess formation (HP:0002722)4.62850871
6Thick nail (HP:0001805)4.08927854
7Abnormality of macrophages (HP:0004311)4.07776350
8Difficulty climbing stairs (HP:0003551)3.64979993
9Myositis (HP:0100614)3.63116594
10Neonatal respiratory distress (HP:0002643)3.52844854
11Mediastinal lymphadenopathy (HP:0100721)3.49868380
12Meningitis (HP:0001287)3.47366967
13Chronic obstructive pulmonary disease (HP:0006510)3.46428728
14Obstructive lung disease (HP:0006536)3.46428728
15Alopecia of scalp (HP:0002293)3.42237283
16Recurrent fungal infections (HP:0002841)3.41261067
17Recurrent gram-negative bacterial infections (HP:0005420)3.36792630
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.30465111
19Cellulitis (HP:0100658)3.26632376
20Orchitis (HP:0100796)3.16754302
21Optic neuritis (HP:0100653)3.16402720
22Retrobulbar optic neuritis (HP:0100654)3.16402720
23Elevated erythrocyte sedimentation rate (HP:0003565)3.11806171
24Keratitis (HP:0000491)3.11646245
25Agammaglobulinemia (HP:0004432)3.08041445
26Recurrent skin infections (HP:0001581)3.07300618
27Recurrent viral infections (HP:0004429)3.04439067
28Oligomenorrhea (HP:0000876)3.03058071
29Recurrent cutaneous fungal infections (HP:0011370)2.99998214
30Chronic mucocutaneous candidiasis (HP:0002728)2.99998214
31Gastrointestinal infarctions (HP:0005244)2.95338907
32Increased IgE level (HP:0003212)2.93147801
33Vasculitis (HP:0002633)2.88471366
34Encephalitis (HP:0002383)2.79153108
35Sepsis (HP:0100806)2.76310094
36Prolonged bleeding time (HP:0003010)2.76174076
37T lymphocytopenia (HP:0005403)2.72388908
38Stomatitis (HP:0010280)2.71268864
39Lymphopenia (HP:0001888)2.69223794
40Panhypogammaglobulinemia (HP:0003139)2.68555087
41Urticaria (HP:0001025)2.68537987
42Colitis (HP:0002583)2.67785409
43Inflammation of the large intestine (HP:0002037)2.65381781
44Gastrointestinal inflammation (HP:0004386)2.63854336
45Granulocytopenia (HP:0001913)2.62044218
46Epistaxis (HP:0000421)2.57068104
47Spontaneous hematomas (HP:0007420)2.55810266
48Gingivitis (HP:0000230)2.55564408
49Abnormality of T cell number (HP:0011839)2.55469374
50Abnormality of cells of the lymphoid lineage (HP:0012140)2.54290131
51Chest pain (HP:0100749)2.52911625
52Acute hepatic failure (HP:0006554)2.50793948
53Osteomyelitis (HP:0002754)2.43468346
54Keratoconjunctivitis sicca (HP:0001097)2.40238765
55Abnormality of T cells (HP:0002843)2.33710543
56Fatigue (HP:0012378)2.33338873
57Abnormality of the neuromuscular junction (HP:0003398)2.33216793
58Fatigable weakness (HP:0003473)2.33216793
59Gastrointestinal stroma tumor (HP:0100723)2.32950094
60Gingival bleeding (HP:0000225)2.32608093
61Supernumerary nipples (HP:0002558)2.32342975
62Increased IgM level (HP:0003496)2.31534783
63Leukocytosis (HP:0001974)2.30198523
64Abnormal platelet volume (HP:0011876)2.29973392
65Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.23343274
66Abnormality of the peritoneum (HP:0002585)2.19342243
67Pustule (HP:0200039)2.14836703
68Milia (HP:0001056)2.14600214
69Arterial thrombosis (HP:0004420)2.14339315
70Episodic fever (HP:0001954)2.11743766
71Autoimmune hemolytic anemia (HP:0001890)2.10362110
72Polycythemia (HP:0001901)2.08989932
73IgM deficiency (HP:0002850)2.08436798
74Keratoconjunctivitis (HP:0001096)2.04879792
75Autoimmune thrombocytopenia (HP:0001973)2.04631095
76Distal upper limb amyotrophy (HP:0007149)2.02501347
77Upper limb amyotrophy (HP:0009129)2.02501347
78Rapidly progressive (HP:0003678)2.00629930
79Abnormal foot bone ossification (HP:0010675)1.99768583
80Recurrent sinusitis (HP:0011108)1.99456132
81Abnormality of T cell physiology (HP:0011840)1.99421550
82Pulmonary infiltrates (HP:0002113)1.99229172
83Severe combined immunodeficiency (HP:0004430)1.98443839
84Hand muscle atrophy (HP:0009130)1.98083900
85Papilloma (HP:0012740)1.97131339
86Verrucae (HP:0200043)1.97131339
87Viral hepatitis (HP:0006562)1.96720644
88Abnormal gallbladder physiology (HP:0012438)1.95783491
89Cholecystitis (HP:0001082)1.95783491
90Abnormality of the fingertips (HP:0001211)1.95096639
91Petechiae (HP:0000967)1.95056362
92Hypertensive crisis (HP:0100735)1.93514335
93Distal lower limb amyotrophy (HP:0008944)1.93142139
94Fragile skin (HP:0001030)1.92133242
95Recurrent bronchitis (HP:0002837)1.91004955
96Hypochromic anemia (HP:0001931)1.88917658
97Slow saccadic eye movements (HP:0000514)1.87593545
98Eosinophilia (HP:0001880)1.82209196
99Hemoptysis (HP:0002105)1.82160294
100Skin ulcer (HP:0200042)1.80396200

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.37300582
2MAP4K13.74961211
3BLK3.59016639
4MAP2K32.54459117
5TYK22.49954648
6IRAK42.42782732
7CDK122.26970872
8TESK22.20059127
9PRPF4B2.17288239
10ERN12.00077286
11CSK1.98307504
12BTK1.88630263
13SYK1.86122620
14SIK21.84632881
15JAK31.78532903
16ZAP701.78024302
17MAP3K141.75217145
18TBK11.74509432
19KSR21.74405288
20GRK61.73293082
21FES1.63613241
22EPHB11.56541487
23IKBKE1.55182850
24HCK1.53514058
25MAP3K131.52439622
26CDC42BPA1.44776362
27CSF1R1.40988621
28BMPR21.36767954
29FGR1.36530442
30MAP3K31.32721186
31JAK11.32325888
32TXK1.30884655
33TNK21.28200860
34LYN1.24187514
35JAK21.20944658
36ITK1.12552544
37LCK1.12028487
38TAOK11.11402750
39STK101.11356730
40TEC1.10472189
41MAP3K51.08947949
42IRAK21.08683867
43TAOK31.08316824
44FGFR41.08160645
45TRIB31.04324757
46SMG10.97914127
47NEK90.96570687
48ICK0.96015483
49IRAK10.94099894
50MATK0.91403899
51MAP3K60.90966670
52EPHA30.87410481
53MAP3K10.87302558
54MARK20.83786768
55TRPM70.83763595
56TAOK20.81919142
57RAF10.80391249
58KIT0.78753282
59MAPK70.78657550
60IRAK30.75897303
61CAMKK20.75749782
62PDK10.73467147
63IKBKB0.73376155
64SIK30.73348816
65SCYL20.73281661
66MAPK110.72646984
67TTN0.72115218
68CLK10.71643531
69RET0.71133959
70YES10.69218070
71FGFR30.67129807
72PIK3CG0.66342938
73KSR10.65755943
74MAPK120.63528851
75BRD40.61433725
76MARK30.59706680
77DAPK30.58945348
78PIM10.57801102
79TGFBR20.57242182
80MAP3K110.51448295
81EIF2AK10.50726741
82LRRK20.49020797
83MAP3K80.48114554
84CDK40.45134980
85PDPK10.44234188
86PRKD20.42867554
87FYN0.42657034
88MAPKAPK20.41483978
89KDR0.39609271
90BMX0.38657599
91CAMKK10.36767688
92MOS0.36093865
93PDGFRB0.34147774
94PTK2B0.34045974
95PRKCQ0.34025182
96EEF2K0.33763201
97STK40.33383978
98HIPK20.32074622
99MTOR0.31567545
100AURKA0.31244382

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.93512408
2Leishmaniasis_Homo sapiens_hsa051402.77294804
3B cell receptor signaling pathway_Homo sapiens_hsa046622.54037455
4Osteoclast differentiation_Homo sapiens_hsa043802.38778183
5Allograft rejection_Homo sapiens_hsa053302.29814778
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.26609283
7Graft-versus-host disease_Homo sapiens_hsa053322.20145604
8Autoimmune thyroid disease_Homo sapiens_hsa053202.16100231
9Staphylococcus aureus infection_Homo sapiens_hsa051502.13354272
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.98615606
11Tuberculosis_Homo sapiens_hsa051521.88356847
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.84190590
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.82477594
14Systemic lupus erythematosus_Homo sapiens_hsa053221.79688445
15Viral myocarditis_Homo sapiens_hsa054161.78868739
16Measles_Homo sapiens_hsa051621.77107031
17Acute myeloid leukemia_Homo sapiens_hsa052211.76562402
18Hematopoietic cell lineage_Homo sapiens_hsa046401.75819099
19Antigen processing and presentation_Homo sapiens_hsa046121.72773961
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.70862032
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.67097911
22T cell receptor signaling pathway_Homo sapiens_hsa046601.66915029
23Influenza A_Homo sapiens_hsa051641.65510529
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.60192080
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.58181501
26Herpes simplex infection_Homo sapiens_hsa051681.53986341
27Other glycan degradation_Homo sapiens_hsa005111.48894968
28Malaria_Homo sapiens_hsa051441.48537429
29Type I diabetes mellitus_Homo sapiens_hsa049401.48004383
30Shigellosis_Homo sapiens_hsa051311.46636818
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.45635452
32Asthma_Homo sapiens_hsa053101.42176162
33Viral carcinogenesis_Homo sapiens_hsa052031.40789083
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39516731
35Toxoplasmosis_Homo sapiens_hsa051451.38984265
36Non-small cell lung cancer_Homo sapiens_hsa052231.36118651
37Legionellosis_Homo sapiens_hsa051341.35868408
38Hepatitis B_Homo sapiens_hsa051611.33027924
39Chemokine signaling pathway_Homo sapiens_hsa040621.29671947
40Pancreatic cancer_Homo sapiens_hsa052121.23497231
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.23418311
42Salmonella infection_Homo sapiens_hsa051321.18797489
43Apoptosis_Homo sapiens_hsa042101.16314420
44Phagosome_Homo sapiens_hsa041451.12844163
45Chronic myeloid leukemia_Homo sapiens_hsa052201.12617082
46TNF signaling pathway_Homo sapiens_hsa046681.06248583
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.06063924
48Epstein-Barr virus infection_Homo sapiens_hsa051691.05575575
49Platelet activation_Homo sapiens_hsa046111.03965040
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99750318
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.96505281
52Spliceosome_Homo sapiens_hsa030400.94350465
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93029545
54Alcoholism_Homo sapiens_hsa050340.91635634
55Hepatitis C_Homo sapiens_hsa051600.90664126
56VEGF signaling pathway_Homo sapiens_hsa043700.90147831
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87470822
58Rheumatoid arthritis_Homo sapiens_hsa053230.87070605
59HTLV-I infection_Homo sapiens_hsa051660.84847124
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84281387
61African trypanosomiasis_Homo sapiens_hsa051430.82596296
62Pertussis_Homo sapiens_hsa051330.81320798
63Renal cell carcinoma_Homo sapiens_hsa052110.80156227
64Prolactin signaling pathway_Homo sapiens_hsa049170.78392149
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77962729
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75596019
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69814819
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.69268571
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66622908
70Lysosome_Homo sapiens_hsa041420.65484172
71Endocytosis_Homo sapiens_hsa041440.64523858
72Colorectal cancer_Homo sapiens_hsa052100.64393325
73Inositol phosphate metabolism_Homo sapiens_hsa005620.61019530
74HIF-1 signaling pathway_Homo sapiens_hsa040660.59970590
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59324745
76Choline metabolism in cancer_Homo sapiens_hsa052310.58511023
77Endometrial cancer_Homo sapiens_hsa052130.58213773
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57830991
79Notch signaling pathway_Homo sapiens_hsa043300.57613906
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.50820018
81ErbB signaling pathway_Homo sapiens_hsa040120.50320433
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50004607
83FoxO signaling pathway_Homo sapiens_hsa040680.49726563
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.46654890
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.46079829
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45412780
87Amoebiasis_Homo sapiens_hsa051460.44497208
88Non-homologous end-joining_Homo sapiens_hsa034500.43857890
89Bladder cancer_Homo sapiens_hsa052190.43035428
90mTOR signaling pathway_Homo sapiens_hsa041500.43031194
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42548670
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42503392
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42473879
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.42427850
95GnRH signaling pathway_Homo sapiens_hsa049120.40943282
96Fructose and mannose metabolism_Homo sapiens_hsa000510.39982099
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39277495
98Pentose phosphate pathway_Homo sapiens_hsa000300.38785107
99Base excision repair_Homo sapiens_hsa034100.38034202
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35177872

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »