ARPC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.02506197
2neutrophil activation involved in immune response (GO:0002283)4.95459966
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.62360782
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.62360782
5antigen processing and presentation of endogenous antigen (GO:0019883)4.59728624
6* Arp2/3 complex-mediated actin nucleation (GO:0034314)4.50501860
7positive regulation of gamma-delta T cell activation (GO:0046645)4.35240554
8leukocyte aggregation (GO:0070486)4.26735977
9respiratory burst (GO:0045730)3.98218916
10immunoglobulin mediated immune response (GO:0016064)3.92997115
11regulation of B cell receptor signaling pathway (GO:0050855)3.91239774
12sequestering of actin monomers (GO:0042989)3.79611855
13neutrophil activation (GO:0042119)3.79109609
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.77916545
15detection of other organism (GO:0098543)3.74470876
16response to peptidoglycan (GO:0032494)3.73041935
17positive regulation by symbiont of host defense response (GO:0052509)3.64867527
18modulation by symbiont of host defense response (GO:0052031)3.64867527
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.64867527
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.64867527
21positive regulation by organism of defense response of other organism involved in symbiotic interact3.64867527
22modulation by symbiont of host immune response (GO:0052553)3.64867527
23granulocyte activation (GO:0036230)3.63059582
24detection of bacterium (GO:0016045)3.46043230
25detection of molecule of bacterial origin (GO:0032490)3.45347500
26positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.42659594
27positive regulation of interferon-alpha production (GO:0032727)3.41998735
28detection of external biotic stimulus (GO:0098581)3.35414648
29* actin nucleation (GO:0045010)3.34718539
30positive regulation of lamellipodium assembly (GO:0010592)3.32363519
31type I interferon signaling pathway (GO:0060337)3.30321652
32cellular response to type I interferon (GO:0071357)3.30321652
33response to type I interferon (GO:0034340)3.29029723
34regulation of interferon-alpha production (GO:0032647)3.27780640
35positive regulation of antigen processing and presentation (GO:0002579)3.25426665
36microglial cell activation (GO:0001774)3.24158580
37interferon-gamma-mediated signaling pathway (GO:0060333)3.22692483
38B cell mediated immunity (GO:0019724)3.21798140
39regulation of interleukin-12 biosynthetic process (GO:0045075)3.19255953
40regulation of B cell differentiation (GO:0045577)3.18121450
41T cell migration (GO:0072678)3.17100102
42positive regulation of B cell differentiation (GO:0045579)3.14198906
43cellular response to zinc ion (GO:0071294)3.12427948
44myeloid dendritic cell activation (GO:0001773)3.10660735
45NIK/NF-kappaB signaling (GO:0038061)3.05774857
46regulation of interferon-beta biosynthetic process (GO:0045357)3.05511656
47regulation of dendritic cell antigen processing and presentation (GO:0002604)3.04393098
48regulation of mast cell activation involved in immune response (GO:0033006)3.02569534
49positive regulation of mast cell activation involved in immune response (GO:0033008)3.00427430
50positive regulation of mast cell degranulation (GO:0043306)3.00427430
51regulation of T cell tolerance induction (GO:0002664)2.99224070
52antigen processing and presentation via MHC class Ib (GO:0002475)2.98580892
53myeloid dendritic cell differentiation (GO:0043011)2.97933757
54defense response to protozoan (GO:0042832)2.97250329
55positive regulation of monocyte chemotaxis (GO:0090026)2.96662687
56cellular response to interferon-beta (GO:0035458)2.96660913
57cellular extravasation (GO:0045123)2.96352226
58negative thymic T cell selection (GO:0045060)2.95310489
59regulation of antigen processing and presentation (GO:0002577)2.94859112
60regulation of natural killer cell mediated immunity (GO:0002715)2.94292247
61regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.94292247
62response to protozoan (GO:0001562)2.93620475
63B cell receptor signaling pathway (GO:0050853)2.93477164
64myeloid cell activation involved in immune response (GO:0002275)2.93194498
65macrophage activation (GO:0042116)2.92172862
66positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.91825965
67regulation of regulatory T cell differentiation (GO:0045589)2.91723313
68response to muramyl dipeptide (GO:0032495)2.91469986
69positive regulation of macrophage differentiation (GO:0045651)2.91176823
70leukocyte cell-cell adhesion (GO:0007159)2.90745821
71negative regulation of phagocytosis (GO:0050765)2.90745401
72positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.90142310
73barbed-end actin filament capping (GO:0051016)2.89854102
74positive regulation of lamellipodium organization (GO:1902745)2.88618563
75response to interferon-beta (GO:0035456)2.88540077
76regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.88336870
77negative regulation of cell killing (GO:0031342)2.88128914
78negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.88128914
79negative T cell selection (GO:0043383)2.86082087
80natural killer cell mediated immunity (GO:0002228)2.85594118
81natural killer cell mediated cytotoxicity (GO:0042267)2.85594118
82detection of biotic stimulus (GO:0009595)2.85336577
83dendritic cell migration (GO:0036336)2.85161561
84T-helper 1 type immune response (GO:0042088)2.84049363
85regulation of alpha-beta T cell proliferation (GO:0046640)2.83199868
86lipopolysaccharide-mediated signaling pathway (GO:0031663)2.82608368
87regulation of tolerance induction (GO:0002643)2.82181121
88regulation of T cell mediated cytotoxicity (GO:0001914)2.81862271
89negative regulation of lymphocyte mediated immunity (GO:0002707)2.81637275
90regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.81511532
91cellular response to interleukin-15 (GO:0071350)2.80675631
92production of molecular mediator involved in inflammatory response (GO:0002532)2.78917569
93positive regulation of T cell mediated cytotoxicity (GO:0001916)2.78804606
94positive regulation of alpha-beta T cell proliferation (GO:0046641)2.78600319
95regulation of gamma-delta T cell differentiation (GO:0045586)2.78504829
96positive regulation of mast cell activation (GO:0033005)2.78469869
97regulation of gamma-delta T cell activation (GO:0046643)2.77184452
98hepatocyte apoptotic process (GO:0097284)2.76563301
99negative regulation of T cell mediated immunity (GO:0002710)2.76094852
100macrophage activation involved in immune response (GO:0002281)2.75767544
101lymphocyte chemotaxis (GO:0048247)2.75287661
102regulation of leukocyte degranulation (GO:0043300)2.74799987
103dendritic cell chemotaxis (GO:0002407)2.74654288
104mast cell activation (GO:0045576)2.73236962
105regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.72599358
106positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.71703622
107regulation of T-helper 1 cell differentiation (GO:0045625)2.71577175
108regulation of myeloid leukocyte mediated immunity (GO:0002886)2.70680394
109leukocyte mediated cytotoxicity (GO:0001909)2.70404920
110negative regulation of leukocyte mediated immunity (GO:0002704)2.69773656
111regulation of mast cell activation (GO:0033003)2.69521663
112antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.68613004
113negative regulation of interleukin-17 production (GO:0032700)2.68464994
114positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.67511980
115response to host (GO:0075136)2.67364452
116response to host defenses (GO:0052200)2.67364452
117response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.67364452
118response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.65700179
119response to host immune response (GO:0052572)2.65700179
120hydrogen peroxide biosynthetic process (GO:0050665)2.64832127
121regulation of mast cell degranulation (GO:0043304)2.64751142
122positive regulation of isotype switching (GO:0045830)2.64735868
123positive regulation of chemokine biosynthetic process (GO:0045080)2.63411228
124leukocyte degranulation (GO:0043299)2.63274255
125JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.62594587
126regulation of T cell receptor signaling pathway (GO:0050856)2.62480081
127interferon-gamma production (GO:0032609)2.61601488
128dendritic cell differentiation (GO:0097028)2.61317521
129signal peptide processing (GO:0006465)2.60443077
130regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.59179833
131myeloid leukocyte activation (GO:0002274)2.59170708
132positive regulation of natural killer cell differentiation (GO:0032825)2.58073221
133negative regulation of interleukin-12 production (GO:0032695)2.56333553
134response to interleukin-15 (GO:0070672)2.56300611
135regulation of RIG-I signaling pathway (GO:0039535)2.53282807
136natural killer cell activation (GO:0030101)2.52387262
137positive regulation of interferon-beta production (GO:0032728)2.50589646

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.31036888
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.97179916
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.08084605
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.88838695
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.57136643
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.45815237
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.23337473
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.15577435
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.11812858
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.02573618
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.01742612
12MYB_21317192_ChIP-Seq_ERMYB_Mouse3.01474806
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.91794681
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.75784498
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.74153028
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.64469476
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.63420978
18* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.54623799
19* SPI1_23547873_ChIP-Seq_NB4_Human2.52353913
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.47054710
21* MYB_26560356_Chip-Seq_TH2_Human2.28592595
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.26526086
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.24955624
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.22507478
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.19824699
26* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.14382319
27E2F7_22180533_ChIP-Seq_HELA_Human2.11221195
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.10245409
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.08229663
30* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00314643
31MAF_26560356_Chip-Seq_TH1_Human1.99581350
32* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.97124858
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.95088268
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.92411999
35VDR_21846776_ChIP-Seq_THP-1_Human1.91324807
36VDR_24763502_ChIP-Seq_THP-1_Human1.88013391
37SCL_19346495_ChIP-Seq_HPC-7_Human1.86444739
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.85464920
39MYB_26560356_Chip-Seq_TH1_Human1.83809505
40MYC_22102868_ChIP-Seq_BL_Human1.82027123
41* RUNX_20019798_ChIP-Seq_JUKART_Human1.77511025
42* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.75982542
43* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.73492833
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70112761
45UTX_26944678_Chip-Seq_JUKART_Human1.59525196
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54781883
47PU_27001747_Chip-Seq_BMDM_Mouse1.51877905
48* SPI1_23127762_ChIP-Seq_K562_Human1.50788190
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.50199824
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47710690
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46588163
52* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45131712
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43192150
54CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42978717
55GATA3_27048872_Chip-Seq_THYMUS_Human1.37940058
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36219789
57* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36157285
58ELK1_19687146_ChIP-ChIP_HELA_Human1.35125220
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34270684
60TP63_17297297_ChIP-ChIP_HaCaT_Human1.31994382
61* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.30166312
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29029356
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.28709064
64VDR_23849224_ChIP-Seq_CD4+_Human1.24199918
65PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23639512
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22314048
67* TFEB_21752829_ChIP-Seq_HELA_Human1.21248103
68CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20834721
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20700966
70GATA1_22025678_ChIP-Seq_K562_Human1.18830376
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.17354776
72* MAF_26560356_Chip-Seq_TH2_Human1.16853595
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14986161
74* GATA3_26560356_Chip-Seq_TH2_Human1.13178650
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12023147
76* TCF7_22412390_ChIP-Seq_EML_Mouse1.09773629
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09355571
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09131026
79RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08572747
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.06925868
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05918479
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05868251
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05263317
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99497035
85PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98823735
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97389478
87GATA2_21666600_ChIP-Seq_HMVEC_Human0.96720196
88EST1_17652178_ChIP-ChIP_JURKAT_Human0.96499737
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94438933
90CREB1_15753290_ChIP-ChIP_HEK293T_Human0.91832480
91VDR_24787735_ChIP-Seq_THP-1_Human0.91578462
92JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91164355
93GATA1_19941826_ChIP-Seq_K562_Human0.89668036
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88358683
95GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87056565
96PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86291554
97JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84510597
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84212874
99PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83657925
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.82687971
101FOXP3_21729870_ChIP-Seq_TREG_Human0.80633452
102NELFA_20434984_ChIP-Seq_ESCs_Mouse0.80281019
103ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.80017023
104FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79477115
105SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79301059
106SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.79301059
107MYC_18555785_ChIP-Seq_MESCs_Mouse0.77944406
108IKZF1_21737484_ChIP-ChIP_HCT116_Human0.77408124
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77128603
110GATA2_19941826_ChIP-Seq_K562_Human0.76902844
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76871625
112EGR1_19032775_ChIP-ChIP_M12_Human0.76782653
113JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.76614599
114SMRT_27268052_Chip-Seq_Bcells_Human0.71520625
115BCL6_27268052_Chip-Seq_Bcells_Human0.71270960
116VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.64796493
117* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.64185129
118PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.63887472
119STAT1_20625510_ChIP-Seq_HELA_Human0.61622221
120GATA3_26560356_Chip-Seq_TH1_Human0.61340598
121* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61075085
122SALL4_22934838_ChIP-ChIP_CD34+_Human0.59688990

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.45136436
2MP0003436_decreased_susceptibility_to3.60919522
3MP0009785_altered_susceptibility_to3.51454242
4MP0000685_abnormal_immune_system3.16823700
5MP0002148_abnormal_hypersensitivity_rea3.14673520
6MP0005671_abnormal_response_to3.12501795
7MP0005000_abnormal_immune_tolerance3.08216733
8MP0001790_abnormal_immune_system2.83660719
9MP0005387_immune_system_phenotype2.83660719
10MP0002419_abnormal_innate_immunity2.81945389
11MP0005025_abnormal_response_to2.80457686
12MP0003303_peritoneal_inflammation2.78507302
13MP0002452_abnormal_antigen_presenting2.76487681
14MP0001800_abnormal_humoral_immune2.73218602
15MP0002723_abnormal_immune_serum2.58642187
16MP0003724_increased_susceptibility_to2.56614307
17MP0001819_abnormal_immune_cell2.55251586
18MP0002420_abnormal_adaptive_immunity2.54752516
19MP0006082_CNS_inflammation2.40444287
20MP0003763_abnormal_thymus_physiology2.20250223
21MP0002405_respiratory_system_inflammati2.16805933
22MP0002166_altered_tumor_susceptibility2.12948312
23MP0002398_abnormal_bone_marrow2.10066844
24MP0005464_abnormal_platelet_physiology2.06886753
25MP0009333_abnormal_splenocyte_physiolog2.02031245
26MP0001853_heart_inflammation2.01259046
27MP0000716_abnormal_immune_system1.98756698
28MP0002006_tumorigenesis1.97096125
29MP0001533_abnormal_skeleton_physiology1.96315100
30MP0010155_abnormal_intestine_physiology1.87704552
31MP0001845_abnormal_inflammatory_respons1.87272516
32MP0004947_skin_inflammation1.85938467
33MP0005058_abnormal_lysosome_morphology1.82274658
34MP0004510_myositis1.71549015
35MP0002429_abnormal_blood_cell1.67521571
36MP0000689_abnormal_spleen_morphology1.67474090
37MP0003300_gastrointestinal_ulcer1.67443644
38MP0000858_altered_metastatic_potential1.64630118
39MP0002722_abnormal_immune_system1.63300342
40MP0002396_abnormal_hematopoietic_system1.61684497
41MP0001545_abnormal_hematopoietic_system1.59218813
42MP0005397_hematopoietic_system_phenotyp1.59218813
43MP0003806_abnormal_nucleotide_metabolis1.59200105
44MP0003448_altered_tumor_morphology1.54907652
45MP0005310_abnormal_salivary_gland1.50915193
46MP0001873_stomach_inflammation1.46918673
47MP0002933_joint_inflammation1.46661110
48MP0000569_abnormal_digit_pigmentation1.43548559
49MP0006054_spinal_hemorrhage1.43427413
50MP0008469_abnormal_protein_level1.43162431
51MP0004808_abnormal_hematopoietic_stem1.40436119
52MP0000343_altered_response_to1.36632194
53MP0000490_abnormal_crypts_of1.35951878
54MP0004883_abnormal_blood_vessel1.33588107
55MP0009764_decreased_sensitivity_to1.33547356
56MP0000465_gastrointestinal_hemorrhage1.31665205
57MP0003172_abnormal_lysosome_physiology1.27629015
58MP0009278_abnormal_bone_marrow1.25349233
59MP0003183_abnormal_peptide_metabolism1.25245420
60MP0003866_abnormal_defecation1.22738567
61MP0010352_gastrointestinal_tract_polyps1.22343195
62MP0008004_abnormal_stomach_pH1.21351885
63MP0000703_abnormal_thymus_morphology1.21350307
64MP0002877_abnormal_melanocyte_morpholog1.15816823
65MP0008260_abnormal_autophagy1.12128778
66MP0002998_abnormal_bone_remodeling1.11991936
67MP0003191_abnormal_cellular_cholesterol1.11186225
68MP0003186_abnormal_redox_activity1.03195831
69MP0005451_abnormal_body_composition1.02528188
70MP0005174_abnormal_tail_pigmentation1.01326334
71MP0002138_abnormal_hepatobiliary_system0.99501056
72MP0001542_abnormal_bone_strength0.96676244
73MP0003566_abnormal_cell_adhesion0.95134514
74MP0001348_abnormal_lacrimal_gland0.93989250
75MP0005390_skeleton_phenotype0.93785448
76MP0001851_eye_inflammation0.91768529
77MP0004782_abnormal_surfactant_physiolog0.91407872
78MP0003075_altered_response_to0.89862246
79MP0005166_decreased_susceptibility_to0.89487813
80MP0003693_abnormal_embryo_hatching0.86162147
81MP0003045_fibrosis0.84879427
82MP0002019_abnormal_tumor_incidence0.84048740
83MP0002132_abnormal_respiratory_system0.83011960
84MP0000015_abnormal_ear_pigmentation0.81090956
85MP0010307_abnormal_tumor_latency0.81051280
86MP0005023_abnormal_wound_healing0.79258170
87MP0003795_abnormal_bone_structure0.78635839
88MP0003828_pulmonary_edema0.75753600
89MP0000249_abnormal_blood_vessel0.73223255
90MP0003656_abnormal_erythrocyte_physiolo0.72379982
91MP0009763_increased_sensitivity_to0.71383402
92MP0009840_abnormal_foam_cell0.71304810
93MP0005164_abnormal_response_to0.70795894
94MP0002163_abnormal_gland_morphology0.70504186
95MP0005165_increased_susceptibility_to0.70238830
96MP0009765_abnormal_xenobiotic_induced0.69388088
97MP0005167_abnormal_blood-brain_barrier0.68873145
98MP0003091_abnormal_cell_migration0.67129488
99MP0001663_abnormal_digestive_system0.66112373
100MP0003690_abnormal_glial_cell0.66011141
101MP0005076_abnormal_cell_differentiation0.65775176
102MP0002136_abnormal_kidney_physiology0.64948691
103MP0002693_abnormal_pancreas_physiology0.64153738
104MP0005084_abnormal_gallbladder_morpholo0.62122787
105MP0003279_aneurysm0.60763586
106MP0001958_emphysema0.60171765
107MP0003453_abnormal_keratinocyte_physiol0.59929064
108MP0002139_abnormal_hepatobiliary_system0.59675384
109MP0000604_amyloidosis0.59347164
110MP0005075_abnormal_melanosome_morpholog0.59173508
111MP0001879_abnormal_lymphatic_vessel0.58331809
112MP0008007_abnormal_cellular_replicative0.57905325
113MP0002277_abnormal_respiratory_mucosa0.56943724
114MP0001243_abnormal_dermal_layer0.56810084
115MP0005319_abnormal_enzyme/_coenzyme0.56404317
116MP0008874_decreased_physiological_sensi0.56219733
117MP0000920_abnormal_myelination0.56185325
118MP0002332_abnormal_exercise_endurance0.55332950

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.24376326
2Recurrent abscess formation (HP:0002722)6.18299172
3Recurrent bacterial skin infections (HP:0005406)5.39864208
4Elevated erythrocyte sedimentation rate (HP:0003565)4.89789069
5Myositis (HP:0100614)4.44348856
6Recurrent gram-negative bacterial infections (HP:0005420)4.29958501
7Abnormality of macrophages (HP:0004311)4.24592035
8Recurrent fungal infections (HP:0002841)4.10403873
9Vacuolated lymphocytes (HP:0001922)4.03996654
10Mediastinal lymphadenopathy (HP:0100721)3.86134580
11Autoimmune thrombocytopenia (HP:0001973)3.69147793
12Orchitis (HP:0100796)3.68863800
13Recurrent skin infections (HP:0001581)3.62736158
14Recurrent viral infections (HP:0004429)3.57196772
15Obstructive lung disease (HP:0006536)3.53656446
16Chronic obstructive pulmonary disease (HP:0006510)3.53656446
17Cellulitis (HP:0100658)3.50994112
18Optic neuritis (HP:0100653)3.43104943
19Retrobulbar optic neuritis (HP:0100654)3.43104943
20Chronic otitis media (HP:0000389)3.34588054
21Petechiae (HP:0000967)3.31593964
22Vasculitis (HP:0002633)3.24483862
23Meningitis (HP:0001287)3.17402295
24Gingivitis (HP:0000230)3.13187654
25Interstitial pulmonary disease (HP:0006530)3.12122979
26IgM deficiency (HP:0002850)3.06518786
27Recurrent bronchitis (HP:0002837)3.06327855
28Recurrent cutaneous fungal infections (HP:0011370)3.03066608
29Chronic mucocutaneous candidiasis (HP:0002728)3.03066608
30Abnormality of T cell number (HP:0011839)2.96754837
31Increased cerebral lipofuscin (HP:0011813)2.95942572
32Gingival bleeding (HP:0000225)2.95715491
33Pustule (HP:0200039)2.94423412
34Increased IgM level (HP:0003496)2.94374660
35Stomatitis (HP:0010280)2.92514651
36Increased neuronal autofluorescent lipopigment (HP:0002074)2.91061190
37Thrombocytosis (HP:0001894)2.90535056
38Abnormality of T cells (HP:0002843)2.82385471
39Abnormality of T cell physiology (HP:0011840)2.76324350
40T lymphocytopenia (HP:0005403)2.74651441
41Leukocytosis (HP:0001974)2.73447001
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.69654612
43Hypergammaglobulinemia (HP:0010702)2.68997877
44Loss of speech (HP:0002371)2.67340901
45Hepatosplenomegaly (HP:0001433)2.65841668
46Spontaneous hematomas (HP:0007420)2.65051592
47Osteomyelitis (HP:0002754)2.61338746
48Agammaglobulinemia (HP:0004432)2.60616026
49Pulmonary infiltrates (HP:0002113)2.60607891
50Recurrent pneumonia (HP:0006532)2.59129541
51Dysostosis multiplex (HP:0000943)2.55834333
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.53448686
53Severe combined immunodeficiency (HP:0004430)2.51597084
54Lymphopenia (HP:0001888)2.50568502
55Thyroiditis (HP:0100646)2.49377871
56Panhypogammaglobulinemia (HP:0003139)2.49341055
57Urticaria (HP:0001025)2.48636876
58Arterial thrombosis (HP:0004420)2.48390096
59Basal ganglia calcification (HP:0002135)2.47965676
60Periodontitis (HP:0000704)2.46818460
61Eosinophilia (HP:0001880)2.45451686
62Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.41438627
63Hemoptysis (HP:0002105)2.40314925
64Combined immunodeficiency (HP:0005387)2.39657130
65Abnormal platelet volume (HP:0011876)2.35389286
66Recurrent lower respiratory tract infections (HP:0002783)2.34032625
67Keratoconjunctivitis sicca (HP:0001097)2.33925833
68B lymphocytopenia (HP:0010976)2.33870381
69Abnormality of B cell number (HP:0010975)2.33870381
70Pulmonary embolism (HP:0002204)2.32889406
71Autoimmune hemolytic anemia (HP:0001890)2.32175243
72Increased IgE level (HP:0003212)2.30447555
73Granulocytopenia (HP:0001913)2.29272987
74IgG deficiency (HP:0004315)2.29199621
75Inflammation of the large intestine (HP:0002037)2.29066444
76Sepsis (HP:0100806)2.25778905
77Gastrointestinal infarctions (HP:0005244)2.25294544
78Abnormality of eosinophils (HP:0001879)2.25194020
79Abnormality of the prostate (HP:0008775)2.25145209
80Glomerulopathy (HP:0100820)2.24382912
81Gastrointestinal inflammation (HP:0004386)2.23555597
82Poor head control (HP:0002421)2.23007386
83Gangrene (HP:0100758)2.22896268
84Abnormality of glycosphingolipid metabolism (HP:0004343)2.22056169
85Abnormality of glycolipid metabolism (HP:0010969)2.22056169
86Abnormality of liposaccharide metabolism (HP:0010968)2.22056169
87Skin ulcer (HP:0200042)2.20502506
88Hematochezia (HP:0002573)2.18411957
89Joint swelling (HP:0001386)2.17618061
90Abnormality of the nasal mucosa (HP:0000433)2.15981840
91Nasal polyposis (HP:0100582)2.15590205
92Keratoconjunctivitis (HP:0001096)2.14791948
93Systemic lupus erythematosus (HP:0002725)2.14765650
94Mucopolysacchariduria (HP:0008155)2.13695913
95Urinary glycosaminoglycan excretion (HP:0003541)2.13695913
96Anorexia (HP:0002039)2.13527244
97Gastrointestinal stroma tumor (HP:0100723)2.13097303
98Encephalitis (HP:0002383)2.13089367
99Progressive neurologic deterioration (HP:0002344)2.11200475
100Episodic fever (HP:0001954)2.10857696
101Abnormality of polysaccharide metabolism (HP:0011012)2.10701641
102Acute hepatic failure (HP:0006554)2.10438692
103Vertebral compression fractures (HP:0002953)2.10405356
104Abnormality of the vasculature of the conjunctiva (HP:0008054)2.09739055
105Abnormality of the pleura (HP:0002103)2.08630157
106Polyneuropathy (HP:0001271)2.07356340
107Increased serum ferritin (HP:0003281)2.06989727
108Peritonitis (HP:0002586)2.06479638
109Amyloidosis (HP:0011034)2.03982230
110Chest pain (HP:0100749)2.03967727
111Epistaxis (HP:0000421)2.02414136
112Myocardial infarction (HP:0001658)2.02382493
113Increased mean platelet volume (HP:0011877)2.01326427
114Colitis (HP:0002583)2.00546276
115IgA deficiency (HP:0002720)2.00310793
116Abnormality of iron homeostasis (HP:0011031)1.97382715
117Chronic diarrhea (HP:0002028)1.94749142
118Lymphoma (HP:0002665)1.93340774
119Disinhibition (HP:0000734)1.92647058
120Purpura (HP:0000979)1.91913916
121Prolonged bleeding time (HP:0003010)1.90951700
122Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90749670
123Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90749670

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.59541404
2BLK3.37098672
3MAP3K143.11072225
4IRAK43.02615428
5TBK12.87692777
6JAK32.61842073
7TXK2.53919220
8TYK22.52087105
9ZAP702.48311952
10RIPK42.35160807
11PIM22.34983275
12TESK12.26566442
13GRK72.23719019
14IKBKE2.16940468
15ERN12.16503416
16KDR2.07912216
17NME22.04962499
18TESK22.01268511
19KIT1.86689130
20MST41.82978819
21BTK1.78636552
22TEC1.78315740
23IKBKB1.75025420
24IRAK31.73578924
25SYK1.71416464
26STK101.58969235
27RPS6KA41.56244700
28ITK1.41896984
29CSK1.36967032
30LRRK21.34918953
31SCYL21.31764329
32MAP3K121.31076075
33JAK11.29036610
34PBK1.28876371
35LCK1.24316730
36CSF1R1.21670233
37HCK1.18617576
38LIMK11.17124564
39LYN1.15251249
40NEK91.13704976
41CHUK1.12055017
42GRK61.11530505
43PIM11.06728267
44PRPF4B1.05293242
45MAP3K111.02568018
46FLT31.01554511
47MYLK1.01310132
48TAOK21.01270940
49FGFR40.98069868
50EPHB10.93838312
51MAP2K30.92391384
52CLK10.92296482
53NLK0.91737166
54ADRBK20.91328265
55MOS0.88432550
56TAOK10.87540239
57MARK30.87279738
58MAP3K130.86171778
59ERBB30.85547201
60EIF2AK10.83877967
61TGFBR20.83170245
62EIF2AK30.82508141
63ACVR1B0.81837899
64SIK30.80906950
65TNK20.80818672
66FGFR30.79394683
67EPHA30.78543247
68TRIB30.77267214
69TRPM70.77107473
70MAP3K100.74393868
71MATK0.72135453
72PTK2B0.68742588
73TGFBR10.68627558
74STK240.67598829
75JAK20.65020598
76FES0.63642047
77ABL20.62914536
78PRKCD0.60284698
79MAP3K30.57958742
80PIK3CG0.56982404
81PKN20.56671174
82TAOK30.56358158
83STK40.56196015
84PDK10.56036620
85MAP3K10.55828953
86FYN0.55390092
87ARAF0.54363650
88PRKG20.53709775
89CAMKK20.52239328
90CDK190.50924976
91PAK40.50356675
92DDR20.50080570
93CDK60.45293144
94ABL10.45230444
95PTK60.45131299
96PRKCQ0.44822267
97* MAPKAPK20.43324145
98MAP3K60.43308210
99BMPR20.43119984
100IRAK10.42912552
101EIF2AK20.40865535
102FGR0.40277312
103EGFR0.40118719
104GRK50.39895903
105TRIM280.39850802
106ADRBK10.39054333
107ILK0.38517934
108MAPKAPK30.38062259
109BRSK20.37537552
110MAP3K80.35497638
111INSR0.35440111
112FRK0.35204948
113BCR0.34240788
114RPS6KA60.34039206
115MAP3K50.32736609
116PAK10.32095354
117TLK10.31429820
118DYRK30.31388111
119RAF10.30742761
120PDPK10.30092692
121DYRK1B0.30003222
122YES10.29113439
123PASK0.28890170
124MAP4K20.28301704
125IGF1R0.27502729
126RPS6KA50.26813424

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.01101790
2Primary immunodeficiency_Homo sapiens_hsa053402.50842361
3Graft-versus-host disease_Homo sapiens_hsa053322.38503620
4Allograft rejection_Homo sapiens_hsa053302.28294880
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.26375533
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.14383451
7Legionellosis_Homo sapiens_hsa051342.13223525
8Measles_Homo sapiens_hsa051622.12579107
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.10237165
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.02445776
11Osteoclast differentiation_Homo sapiens_hsa043802.02006668
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.00844415
13Antigen processing and presentation_Homo sapiens_hsa046121.98413494
14Pertussis_Homo sapiens_hsa051331.93137857
15* Shigellosis_Homo sapiens_hsa051311.92656435
16* Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.87439462
17B cell receptor signaling pathway_Homo sapiens_hsa046621.84163255
18Proteasome_Homo sapiens_hsa030501.82055781
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.80670428
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.78603994
21Tuberculosis_Homo sapiens_hsa051521.76039979
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.73872144
23Hematopoietic cell lineage_Homo sapiens_hsa046401.70743435
24Asthma_Homo sapiens_hsa053101.66770472
25Malaria_Homo sapiens_hsa051441.53382892
26Toxoplasmosis_Homo sapiens_hsa051451.51507459
27* Salmonella infection_Homo sapiens_hsa051321.51138646
28Lysosome_Homo sapiens_hsa041421.50819135
29* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47607822
30Apoptosis_Homo sapiens_hsa042101.46765386
31Influenza A_Homo sapiens_hsa051641.44781517
32Herpes simplex infection_Homo sapiens_hsa051681.44518228
33Viral myocarditis_Homo sapiens_hsa054161.43308522
34T cell receptor signaling pathway_Homo sapiens_hsa046601.41492068
35Rheumatoid arthritis_Homo sapiens_hsa053231.40474090
36TNF signaling pathway_Homo sapiens_hsa046681.40339867
37Phagosome_Homo sapiens_hsa041451.40009997
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.38441462
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.37995297
40Staphylococcus aureus infection_Homo sapiens_hsa051501.37928393
41Other glycan degradation_Homo sapiens_hsa005111.37394845
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.34644981
43Type I diabetes mellitus_Homo sapiens_hsa049401.30194189
44Autoimmune thyroid disease_Homo sapiens_hsa053201.27038890
45Chemokine signaling pathway_Homo sapiens_hsa040621.26751767
46* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.25010293
47Hepatitis B_Homo sapiens_hsa051611.23001132
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19139198
49Protein export_Homo sapiens_hsa030601.16389975
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15856517
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10729517
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.10122871
53Epstein-Barr virus infection_Homo sapiens_hsa051690.97204760
54Acute myeloid leukemia_Homo sapiens_hsa052210.96868367
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96557578
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93661856
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91562466
58Hepatitis C_Homo sapiens_hsa051600.88798313
59Platelet activation_Homo sapiens_hsa046110.87217501
60p53 signaling pathway_Homo sapiens_hsa041150.87077266
61Collecting duct acid secretion_Homo sapiens_hsa049660.86811588
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86310377
63DNA replication_Homo sapiens_hsa030300.85615040
64Ribosome_Homo sapiens_hsa030100.85486865
65Chronic myeloid leukemia_Homo sapiens_hsa052200.82373677
66Pancreatic cancer_Homo sapiens_hsa052120.81741136
67African trypanosomiasis_Homo sapiens_hsa051430.80608054
68Sulfur metabolism_Homo sapiens_hsa009200.79303825
69Viral carcinogenesis_Homo sapiens_hsa052030.74156586
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.72634279
71Base excision repair_Homo sapiens_hsa034100.70989381
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69995288
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67195144
74Prolactin signaling pathway_Homo sapiens_hsa049170.65475129
75VEGF signaling pathway_Homo sapiens_hsa043700.64424941
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63747707
77Systemic lupus erythematosus_Homo sapiens_hsa053220.63509457
78HTLV-I infection_Homo sapiens_hsa051660.60934263
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60526694
80* Endocytosis_Homo sapiens_hsa041440.55081196
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.53811422
82Amoebiasis_Homo sapiens_hsa051460.53116023
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52573606
84Vibrio cholerae infection_Homo sapiens_hsa051100.52452158
85Small cell lung cancer_Homo sapiens_hsa052220.48310182
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46137118
87Renin-angiotensin system_Homo sapiens_hsa046140.44609812
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44156510
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43785636
90N-Glycan biosynthesis_Homo sapiens_hsa005100.43348675
91Thyroid cancer_Homo sapiens_hsa052160.42597010
92Mismatch repair_Homo sapiens_hsa034300.42502555
93* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40788067
94Colorectal cancer_Homo sapiens_hsa052100.38720356
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38235069
96HIF-1 signaling pathway_Homo sapiens_hsa040660.34769605
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31301033
98Non-homologous end-joining_Homo sapiens_hsa034500.30125674
99Pyrimidine metabolism_Homo sapiens_hsa002400.29277568
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29084745
101Arachidonic acid metabolism_Homo sapiens_hsa005900.28878167
102Proteoglycans in cancer_Homo sapiens_hsa052050.28556594
103Homologous recombination_Homo sapiens_hsa034400.28466859
104Regulation of autophagy_Homo sapiens_hsa041400.28321246
105Non-small cell lung cancer_Homo sapiens_hsa052230.27886361
106Sphingolipid metabolism_Homo sapiens_hsa006000.27589393
107Caffeine metabolism_Homo sapiens_hsa002320.27115862
108Complement and coagulation cascades_Homo sapiens_hsa046100.25867507
109Cell cycle_Homo sapiens_hsa041100.24416502
110Galactose metabolism_Homo sapiens_hsa000520.19784177
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.16363295
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.14783006
113Renal cell carcinoma_Homo sapiens_hsa052110.12765238
114Mineral absorption_Homo sapiens_hsa049780.11722016
115Bladder cancer_Homo sapiens_hsa052190.10318203
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07831550
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.05184125

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