Rank | Gene Set | Z-score |
---|---|---|
1 | proteasome assembly (GO:0043248) | 4.76364910 |
2 | DNA deamination (GO:0045006) | 4.50247614 |
3 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.29414870 |
4 | chaperone-mediated protein transport (GO:0072321) | 4.18324890 |
5 | ribosomal small subunit assembly (GO:0000028) | 4.11533281 |
6 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.97397677 |
7 | formation of translation preinitiation complex (GO:0001731) | 3.92621817 |
8 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.91156653 |
9 | ribosomal large subunit biogenesis (GO:0042273) | 3.79259004 |
10 | telomere maintenance via recombination (GO:0000722) | 3.77473721 |
11 | viral transcription (GO:0019083) | 3.76533509 |
12 | DNA strand elongation (GO:0022616) | 3.72465770 |
13 | maturation of SSU-rRNA (GO:0030490) | 3.71774009 |
14 | regulation of translational termination (GO:0006449) | 3.70635060 |
15 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.64769814 |
16 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.63956073 |
17 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.62875691 |
18 | termination of RNA polymerase III transcription (GO:0006386) | 3.62875691 |
19 | translational termination (GO:0006415) | 3.62104177 |
20 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.58116109 |
21 | regulation of mitochondrial translation (GO:0070129) | 3.56278212 |
22 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.54508076 |
23 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.54508076 |
24 | ribosomal small subunit biogenesis (GO:0042274) | 3.54418562 |
25 | DNA replication checkpoint (GO:0000076) | 3.52778762 |
26 | protein deneddylation (GO:0000338) | 3.52126785 |
27 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.51630338 |
28 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.51597887 |
29 | protein targeting to mitochondrion (GO:0006626) | 3.51417092 |
30 | cotranslational protein targeting to membrane (GO:0006613) | 3.50942392 |
31 | protein targeting to ER (GO:0045047) | 3.47258525 |
32 | NIK/NF-kappaB signaling (GO:0038061) | 3.46674738 |
33 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.44421519 |
34 | ribosome assembly (GO:0042255) | 3.43670857 |
35 | cullin deneddylation (GO:0010388) | 3.42798616 |
36 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.41821513 |
37 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.41705652 |
38 | mitotic recombination (GO:0006312) | 3.40194310 |
39 | protein maturation by protein folding (GO:0022417) | 3.39820286 |
40 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.37821615 |
41 | telomere maintenance via telomere lengthening (GO:0010833) | 3.37382158 |
42 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.36039625 |
43 | cytidine deamination (GO:0009972) | 3.33500342 |
44 | cytidine metabolic process (GO:0046087) | 3.33500342 |
45 | cytidine catabolic process (GO:0006216) | 3.33500342 |
46 | translational elongation (GO:0006414) | 3.33208399 |
47 | DNA replication initiation (GO:0006270) | 3.33187166 |
48 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.31278572 |
49 | establishment of protein localization to mitochondrion (GO:0072655) | 3.30988135 |
50 | protein localization to endoplasmic reticulum (GO:0070972) | 3.30260269 |
51 | protein complex biogenesis (GO:0070271) | 3.29423628 |
52 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.29350478 |
53 | GDP-mannose metabolic process (GO:0019673) | 3.28971495 |
54 | CENP-A containing nucleosome assembly (GO:0034080) | 3.28819025 |
55 | rRNA modification (GO:0000154) | 3.28546038 |
56 | pseudouridine synthesis (GO:0001522) | 3.26974488 |
57 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.25611928 |
58 | negative regulation of ligase activity (GO:0051352) | 3.25611928 |
59 | translation (GO:0006412) | 3.25550499 |
60 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.25300965 |
61 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.24783677 |
62 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.24783677 |
63 | chromatin remodeling at centromere (GO:0031055) | 3.23851326 |
64 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.22909691 |
65 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.22591714 |
66 | iron-sulfur cluster assembly (GO:0016226) | 3.21435725 |
67 | metallo-sulfur cluster assembly (GO:0031163) | 3.21435725 |
68 | activation of MAPKKK activity (GO:0000185) | 3.19636634 |
69 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.19300604 |
70 | ATP synthesis coupled proton transport (GO:0015986) | 3.19300604 |
71 | translational initiation (GO:0006413) | 3.18696723 |
72 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.15367448 |
73 | spliceosomal snRNP assembly (GO:0000387) | 3.14881819 |
74 | protein localization to mitochondrion (GO:0070585) | 3.14356109 |
75 | 7-methylguanosine mRNA capping (GO:0006370) | 3.14030641 |
76 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.13864766 |
77 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.12694288 |
78 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.11826480 |
79 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.11199489 |
80 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.09958288 |
81 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.09605622 |
82 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.09605622 |
83 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.09605622 |
84 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 3.08952161 |
85 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.08818083 |
86 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.08818083 |
87 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.07797764 |
88 | RNA capping (GO:0036260) | 3.06145055 |
89 | 7-methylguanosine RNA capping (GO:0009452) | 3.06145055 |
90 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.04723753 |
91 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.03721138 |
92 | NADH dehydrogenase complex assembly (GO:0010257) | 3.03721138 |
93 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.03721138 |
94 | regulation of ligase activity (GO:0051340) | 3.03406823 |
95 | nuclear envelope reassembly (GO:0031468) | 3.03204898 |
96 | mitotic nuclear envelope reassembly (GO:0007084) | 3.03204898 |
97 | establishment of viral latency (GO:0019043) | 3.02390175 |
98 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.02268399 |
99 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.00723410 |
100 | cellular protein complex disassembly (GO:0043624) | 3.00094398 |
101 | respiratory electron transport chain (GO:0022904) | 2.99694320 |
102 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.98750594 |
103 | cellular component biogenesis (GO:0044085) | 2.98555799 |
104 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.97943781 |
105 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.97943781 |
106 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.97719958 |
107 | rRNA processing (GO:0006364) | 2.97093017 |
108 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.96303333 |
109 | ribosome biogenesis (GO:0042254) | 2.95975626 |
110 | maturation of 5.8S rRNA (GO:0000460) | 2.95792828 |
111 | positive regulation of ligase activity (GO:0051351) | 2.95220869 |
112 | electron transport chain (GO:0022900) | 2.94680362 |
113 | spliceosomal complex assembly (GO:0000245) | 2.94297545 |
114 | rRNA methylation (GO:0031167) | 2.93979240 |
115 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.92627947 |
116 | viral life cycle (GO:0019058) | 2.92430297 |
117 | mitotic metaphase plate congression (GO:0007080) | 2.90195949 |
118 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.90154893 |
119 | DNA replication-independent nucleosome organization (GO:0034724) | 2.90154893 |
120 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 2.90094579 |
121 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 2.89924409 |
122 | rRNA transcription (GO:0009303) | 2.89586162 |
123 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling | 2.88479815 |
124 | peptidyl-histidine modification (GO:0018202) | 2.88148522 |
125 | transcription from mitochondrial promoter (GO:0006390) | 2.86348969 |
126 | rRNA metabolic process (GO:0016072) | 2.85653353 |
127 | mitotic chromosome condensation (GO:0007076) | 2.83891193 |
128 | establishment of integrated proviral latency (GO:0075713) | 2.83633137 |
129 | positive regulation of cell cycle arrest (GO:0071158) | 2.79212980 |
130 | peptidyl-arginine omega-N-methylation (GO:0035247) | 2.78958094 |
131 | chaperone mediated protein folding requiring cofactor (GO:0051085) | 2.75719421 |
132 | regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 2.75226931 |
133 | DNA unwinding involved in DNA replication (GO:0006268) | 2.71892172 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.57567159 |
2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.43259794 |
3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.03757245 |
4 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.88752238 |
5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.76570640 |
6 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.64010286 |
7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.33732299 |
8 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.32798226 |
9 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.15488315 |
10 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.11711997 |
11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.00717344 |
12 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.81246577 |
13 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.77311820 |
14 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.69752772 |
15 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.69154468 |
16 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.63394882 |
17 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.50684050 |
18 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.47992650 |
19 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.42064741 |
20 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.38097748 |
21 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.33492345 |
22 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.26769611 |
23 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.26738148 |
24 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.26177118 |
25 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.22441038 |
26 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.18610633 |
27 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.14918940 |
28 | * GABP_19822575_ChIP-Seq_HepG2_Human | 2.14776021 |
29 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.14409858 |
30 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.14266279 |
31 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.10163294 |
32 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.08671518 |
33 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.08605478 |
34 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.04903518 |
35 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.04219178 |
36 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.02369408 |
37 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.00665188 |
38 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.99598367 |
39 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.94527677 |
40 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.93251630 |
41 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.91883443 |
42 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.91514815 |
43 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.87272283 |
44 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.85005455 |
45 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.83219828 |
46 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.83081848 |
47 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.82190453 |
48 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.81700894 |
49 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.73359349 |
50 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.71232324 |
51 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.63572207 |
52 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.62174273 |
53 | * TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.61208915 |
54 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.56093851 |
55 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.48419032 |
56 | * MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.46729097 |
57 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.45385381 |
58 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.43776664 |
59 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.43548746 |
60 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.42775399 |
61 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.41978604 |
62 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.40207531 |
63 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.38005538 |
64 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.37374969 |
65 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.36863405 |
66 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.35656165 |
67 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.31126897 |
68 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.30255225 |
69 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.28507662 |
70 | MAF_26560356_Chip-Seq_TH2_Human | 1.28434939 |
71 | * ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.26974369 |
72 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.24032320 |
73 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.22573077 |
74 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.22325746 |
75 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.21770473 |
76 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.21105554 |
77 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.20403926 |
78 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.19103349 |
79 | * MAF_26560356_Chip-Seq_TH1_Human | 1.18780845 |
80 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.15940576 |
81 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.15809631 |
82 | * MYC_22102868_ChIP-Seq_BL_Human | 1.15536801 |
83 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.12630718 |
84 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.12108272 |
85 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.08024365 |
86 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.07803166 |
87 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.07743784 |
88 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.05819228 |
89 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.05711161 |
90 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.05550680 |
91 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.03918607 |
92 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.03537102 |
93 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.02272733 |
94 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.01825711 |
95 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.01701587 |
96 | UTX_26944678_Chip-Seq_JUKART_Human | 1.01605272 |
97 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.01436185 |
98 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.01026966 |
99 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 1.00831791 |
100 | * ATF3_27146783_Chip-Seq_COLON_Human | 1.00017258 |
101 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.99924514 |
102 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.99119494 |
103 | P68_20966046_ChIP-Seq_HELA_Human | 0.98200134 |
104 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.97621107 |
105 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.97202392 |
106 | * DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.96974686 |
107 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.95976203 |
108 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.95974143 |
109 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.95167437 |
110 | * CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.95088656 |
111 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.93831534 |
112 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.93756780 |
113 | EZH2_22144423_ChIP-Seq_EOC_Human | 0.88147220 |
114 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.86867519 |
115 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.81641601 |
116 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.79579607 |
117 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.79562469 |
118 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.79520871 |
119 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.79225176 |
120 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.79140276 |
121 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.77186948 |
122 | * MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.76696414 |
123 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.75499358 |
124 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.73939682 |
125 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.73402395 |
126 | * TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.73079041 |
127 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.71356041 |
128 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.70366905 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003693_abnormal_embryo_hatching | 4.30887653 |
2 | MP0010094_abnormal_chromosome_stability | 3.63128520 |
3 | MP0004957_abnormal_blastocyst_morpholog | 3.10843893 |
4 | MP0003646_muscle_fatigue | 3.02897049 |
5 | MP0003111_abnormal_nucleus_morphology | 3.00226905 |
6 | MP0008877_abnormal_DNA_methylation | 2.91252771 |
7 | MP0008058_abnormal_DNA_repair | 2.88116183 |
8 | MP0003806_abnormal_nucleotide_metabolis | 2.75536703 |
9 | MP0003077_abnormal_cell_cycle | 2.70707342 |
10 | MP0002796_impaired_skin_barrier | 2.60789682 |
11 | MP0002877_abnormal_melanocyte_morpholog | 2.56740392 |
12 | MP0001986_abnormal_taste_sensitivity | 2.52595735 |
13 | MP0003763_abnormal_thymus_physiology | 2.52275679 |
14 | MP0005451_abnormal_body_composition | 2.45300600 |
15 | MP0005501_abnormal_skin_physiology | 2.44564772 |
16 | MP0001835_abnormal_antigen_presentation | 2.42799473 |
17 | MP0008260_abnormal_autophagy | 2.26182013 |
18 | MP0001800_abnormal_humoral_immune | 2.11088493 |
19 | MP0008007_abnormal_cellular_replicative | 2.05574272 |
20 | MP0006036_abnormal_mitochondrial_physio | 1.99735336 |
21 | MP0003718_maternal_effect | 1.99104977 |
22 | MP0006292_abnormal_olfactory_placode | 1.97886176 |
23 | MP0008057_abnormal_DNA_replication | 1.97067464 |
24 | MP0008932_abnormal_embryonic_tissue | 1.96638539 |
25 | MP0009379_abnormal_foot_pigmentation | 1.95736597 |
26 | MP0005623_abnormal_meninges_morphology | 1.90885188 |
27 | MP0003786_premature_aging | 1.89658061 |
28 | MP0001529_abnormal_vocalization | 1.87918403 |
29 | MP0010234_abnormal_vibrissa_follicle | 1.86935698 |
30 | MP0005671_abnormal_response_to | 1.86252112 |
31 | MP0001188_hyperpigmentation | 1.82404505 |
32 | MP0001790_abnormal_immune_system | 1.81515743 |
33 | MP0005387_immune_system_phenotype | 1.81515743 |
34 | MP0002398_abnormal_bone_marrow | 1.78724330 |
35 | MP0000015_abnormal_ear_pigmentation | 1.66795046 |
36 | MP0003787_abnormal_imprinting | 1.64432333 |
37 | MP0009333_abnormal_splenocyte_physiolog | 1.62855332 |
38 | MP0001984_abnormal_olfaction | 1.61748327 |
39 | MP0004185_abnormal_adipocyte_glucose | 1.60512277 |
40 | MP0003453_abnormal_keratinocyte_physiol | 1.58525330 |
41 | MP0000689_abnormal_spleen_morphology | 1.57526817 |
42 | MP0002420_abnormal_adaptive_immunity | 1.57204658 |
43 | MP0002452_abnormal_antigen_presenting | 1.56596364 |
44 | MP0002163_abnormal_gland_morphology | 1.56590427 |
45 | MP0001905_abnormal_dopamine_level | 1.55905523 |
46 | MP0002160_abnormal_reproductive_system | 1.54433729 |
47 | MP0001819_abnormal_immune_cell | 1.52959602 |
48 | MP0001873_stomach_inflammation | 1.45606563 |
49 | MP0003880_abnormal_central_pattern | 1.44138595 |
50 | MP0000716_abnormal_immune_system | 1.43636417 |
51 | MP0004233_abnormal_muscle_weight | 1.43332450 |
52 | MP0004947_skin_inflammation | 1.43262776 |
53 | MP0000703_abnormal_thymus_morphology | 1.42875631 |
54 | MP0002723_abnormal_immune_serum | 1.42523226 |
55 | MP0000858_altered_metastatic_potential | 1.38024007 |
56 | MP0005000_abnormal_immune_tolerance | 1.37920950 |
57 | MP0003186_abnormal_redox_activity | 1.37703541 |
58 | MP0006035_abnormal_mitochondrial_morpho | 1.37235447 |
59 | MP0002095_abnormal_skin_pigmentation | 1.35776153 |
60 | MP0001727_abnormal_embryo_implantation | 1.35357634 |
61 | MP0002722_abnormal_immune_system | 1.35239262 |
62 | MP0001929_abnormal_gametogenesis | 1.34855255 |
63 | MP0005645_abnormal_hypothalamus_physiol | 1.34631598 |
64 | MP0001216_abnormal_epidermal_layer | 1.30538748 |
65 | MP0002429_abnormal_blood_cell | 1.27283644 |
66 | MP0005389_reproductive_system_phenotype | 1.27033909 |
67 | MP0002210_abnormal_sex_determination | 1.24678577 |
68 | MP0002736_abnormal_nociception_after | 1.21735871 |
69 | MP0002019_abnormal_tumor_incidence | 1.20899476 |
70 | MP0003436_decreased_susceptibility_to | 1.19791402 |
71 | MP0001968_abnormal_touch/_nociception | 1.18150014 |
72 | MP0001919_abnormal_reproductive_system | 1.16936608 |
73 | MP0003941_abnormal_skin_development | 1.16925008 |
74 | MP0004145_abnormal_muscle_electrophysio | 1.16308535 |
75 | MP0002148_abnormal_hypersensitivity_rea | 1.16207530 |
76 | MP0009840_abnormal_foam_cell | 1.15942700 |
77 | MP0002396_abnormal_hematopoietic_system | 1.14273363 |
78 | MP0000490_abnormal_crypts_of | 1.12727989 |
79 | MP0000685_abnormal_immune_system | 1.11114420 |
80 | MP0000313_abnormal_cell_death | 1.09583948 |
81 | MP0010307_abnormal_tumor_latency | 1.09209112 |
82 | MP0001881_abnormal_mammary_gland | 1.09157450 |
83 | MP0001853_heart_inflammation | 1.06082594 |
84 | MP0002080_prenatal_lethality | 1.04164517 |
85 | MP0003123_paternal_imprinting | 1.04039648 |
86 | MP0002837_dystrophic_cardiac_calcinosis | 1.03883764 |
87 | MP0006276_abnormal_autonomic_nervous | 1.03458385 |
88 | MP0010771_integument_phenotype | 1.03354917 |
89 | MP0000372_irregular_coat_pigmentation | 1.03089521 |
90 | MP0002132_abnormal_respiratory_system | 1.02163990 |
91 | MP0005410_abnormal_fertilization | 1.01874022 |
92 | MP0002006_tumorigenesis | 1.01776972 |
93 | MP0002693_abnormal_pancreas_physiology | 1.00405762 |
94 | MP0002138_abnormal_hepatobiliary_system | 0.99401783 |
95 | MP0004808_abnormal_hematopoietic_stem | 0.99157874 |
96 | MP0005646_abnormal_pituitary_gland | 0.98612367 |
97 | MP0003183_abnormal_peptide_metabolism | 0.97740069 |
98 | MP0000653_abnormal_sex_gland | 0.97366195 |
99 | MP0001145_abnormal_male_reproductive | 0.96284870 |
100 | MP0000750_abnormal_muscle_regeneration | 0.96191911 |
101 | MP0009785_altered_susceptibility_to | 0.95541215 |
102 | MP0001348_abnormal_lacrimal_gland | 0.95118932 |
103 | MP0005075_abnormal_melanosome_morpholog | 0.94924670 |
104 | MP0002060_abnormal_skin_morphology | 0.94907015 |
105 | MP0002166_altered_tumor_susceptibility | 0.94507120 |
106 | MP0003698_abnormal_male_reproductive | 0.94260871 |
107 | MP0000579_abnormal_nail_morphology | 0.93997040 |
108 | MP0000350_abnormal_cell_proliferation | 0.91981917 |
109 | MP0005621_abnormal_cell_physiology | 0.88261178 |
110 | MP0001730_embryonic_growth_arrest | 0.88092910 |
111 | MP0003866_abnormal_defecation | 0.87041459 |
112 | MP0002876_abnormal_thyroid_physiology | 0.86327963 |
113 | MP0000627_abnormal_mammary_gland | 0.86169069 |
114 | MP0005384_cellular_phenotype | 0.85481512 |
115 | MP0004142_abnormal_muscle_tone | 0.84372143 |
116 | MP0005379_endocrine/exocrine_gland_phen | 0.83640720 |
117 | MP0001845_abnormal_inflammatory_respons | 0.82889276 |
118 | MP0002751_abnormal_autonomic_nervous | 0.81851032 |
119 | MP0000013_abnormal_adipose_tissue | 0.81835041 |
120 | MP0003121_genomic_imprinting | 0.81447590 |
121 | MP0000749_muscle_degeneration | 0.81376343 |
122 | MP0001119_abnormal_female_reproductive | 0.81374499 |
123 | MP0010155_abnormal_intestine_physiology | 0.80387894 |
124 | MP0001697_abnormal_embryo_size | 0.78136039 |
125 | MP0005310_abnormal_salivary_gland | 0.77444161 |
126 | MP0005025_abnormal_response_to | 0.77057816 |
127 | MP0002638_abnormal_pupillary_reflex | 0.76774871 |
128 | MP0005330_cardiomyopathy | 0.76353582 |
129 | MP0005174_abnormal_tail_pigmentation | 0.76026445 |
130 | MP0010386_abnormal_urinary_bladder | 0.75623437 |
131 | MP0005058_abnormal_lysosome_morphology | 0.75241341 |
132 | MP0009931_abnormal_skin_appearance | 0.74806281 |
133 | MP0001191_abnormal_skin_condition | 0.74765224 |
134 | MP0000358_abnormal_cell_content/ | 0.74695204 |
135 | MP0003448_altered_tumor_morphology | 0.72549853 |
136 | MP0008873_increased_physiological_sensi | 0.71250267 |
137 | MP0000343_altered_response_to | 0.71128351 |
138 | MP0003075_altered_response_to | 0.71054167 |
139 | MP0006072_abnormal_retinal_apoptosis | 0.70334158 |
140 | MP0003221_abnormal_cardiomyocyte_apopto | 0.69311159 |
141 | MP0003315_abnormal_perineum_morphology | 0.69189535 |
142 | MP0009672_abnormal_birth_weight | 0.69041611 |
143 | MP0008789_abnormal_olfactory_epithelium | 0.67116041 |
144 | MP0001672_abnormal_embryogenesis/_devel | 0.66673141 |
145 | MP0000751_myopathy | 0.66516181 |
146 | MP0000631_abnormal_neuroendocrine_gland | 0.65594042 |
147 | MP0002405_respiratory_system_inflammati | 0.63619520 |
148 | MP0001186_pigmentation_phenotype | 0.62958032 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Acute necrotizing encephalopathy (HP:0006965) | 4.51917347 |
2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.28860487 |
3 | Agammaglobulinemia (HP:0004432) | 4.24901602 |
4 | Mitochondrial inheritance (HP:0001427) | 4.20908998 |
5 | Hepatocellular necrosis (HP:0001404) | 3.92320581 |
6 | Increased CSF lactate (HP:0002490) | 3.84887616 |
7 | Progressive macrocephaly (HP:0004481) | 3.68948058 |
8 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.60556747 |
9 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.60556747 |
10 | Acute encephalopathy (HP:0006846) | 3.44355200 |
11 | Hepatic necrosis (HP:0002605) | 3.28937534 |
12 | Increased hepatocellular lipid droplets (HP:0006565) | 3.19751426 |
13 | Testicular atrophy (HP:0000029) | 3.18119758 |
14 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.12804395 |
15 | Ragged-red muscle fibers (HP:0003200) | 3.08795157 |
16 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.08486847 |
17 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.07423985 |
18 | Multiple enchondromatosis (HP:0005701) | 3.07325117 |
19 | Gastrointestinal stroma tumor (HP:0100723) | 3.06671785 |
20 | Trismus (HP:0000211) | 3.03724399 |
21 | Sparse eyelashes (HP:0000653) | 3.01358863 |
22 | Rough bone trabeculation (HP:0100670) | 3.00075669 |
23 | Recurrent sinusitis (HP:0011108) | 3.00074007 |
24 | Abnormal number of erythroid precursors (HP:0012131) | 2.99361847 |
25 | Recurrent bronchitis (HP:0002837) | 2.98899620 |
26 | Reticulocytopenia (HP:0001896) | 2.94355261 |
27 | Birth length less than 3rd percentile (HP:0003561) | 2.91307838 |
28 | IgM deficiency (HP:0002850) | 2.88784378 |
29 | Increased serum lactate (HP:0002151) | 2.88645545 |
30 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.87299639 |
31 | Exercise intolerance (HP:0003546) | 2.83232575 |
32 | Exertional dyspnea (HP:0002875) | 2.81131190 |
33 | Aplastic anemia (HP:0001915) | 2.80814467 |
34 | Lipid accumulation in hepatocytes (HP:0006561) | 2.79335317 |
35 | Chronic sinusitis (HP:0011109) | 2.77559054 |
36 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.76554558 |
37 | Lactic acidosis (HP:0003128) | 2.71432141 |
38 | Increased intramyocellular lipid droplets (HP:0012240) | 2.64848352 |
39 | Squamous cell carcinoma (HP:0002860) | 2.59403826 |
40 | IgG deficiency (HP:0004315) | 2.52459726 |
41 | Panhypogammaglobulinemia (HP:0003139) | 2.52152549 |
42 | Abnormal hair whorl (HP:0010721) | 2.51438898 |
43 | Lymphopenia (HP:0001888) | 2.41625759 |
44 | Selective tooth agenesis (HP:0001592) | 2.41014063 |
45 | Respiratory difficulties (HP:0002880) | 2.40907628 |
46 | Amniotic constriction ring (HP:0009775) | 2.39436285 |
47 | Abnormality of placental membranes (HP:0011409) | 2.39436285 |
48 | Type I transferrin isoform profile (HP:0003642) | 2.38925724 |
49 | Macrocytic anemia (HP:0001972) | 2.37938087 |
50 | Hypertensive crisis (HP:0100735) | 2.37528034 |
51 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.36852948 |
52 | Respiratory failure (HP:0002878) | 2.35946894 |
53 | Verrucae (HP:0200043) | 2.35911639 |
54 | Papilloma (HP:0012740) | 2.35911639 |
55 | B lymphocytopenia (HP:0010976) | 2.34652031 |
56 | Abnormality of B cell number (HP:0010975) | 2.34652031 |
57 | Bronchitis (HP:0012387) | 2.33655257 |
58 | Abnormal trabecular bone morphology (HP:0100671) | 2.33371807 |
59 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.32883473 |
60 | Abnormality of nail color (HP:0100643) | 2.32845410 |
61 | Microvesicular hepatic steatosis (HP:0001414) | 2.32714619 |
62 | Hypokinesia (HP:0002375) | 2.32623412 |
63 | Onycholysis (HP:0001806) | 2.31233598 |
64 | IgA deficiency (HP:0002720) | 2.29659827 |
65 | Fatigue (HP:0012378) | 2.28387835 |
66 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.28009684 |
67 | Chromsome breakage (HP:0040012) | 2.25641605 |
68 | Meningitis (HP:0001287) | 2.25471606 |
69 | Optic disc pallor (HP:0000543) | 2.22865889 |
70 | Fasciculations (HP:0002380) | 2.21861810 |
71 | Renal Fanconi syndrome (HP:0001994) | 2.21423636 |
72 | Recurrent viral infections (HP:0004429) | 2.21267397 |
73 | Medial flaring of the eyebrow (HP:0010747) | 2.19951238 |
74 | Fragile nails (HP:0001808) | 2.19236015 |
75 | Increased muscle lipid content (HP:0009058) | 2.18144397 |
76 | Breast hypoplasia (HP:0003187) | 2.17458846 |
77 | Patellar aplasia (HP:0006443) | 2.17288753 |
78 | Premature ovarian failure (HP:0008209) | 2.17281252 |
79 | Abnormality of the preputium (HP:0100587) | 2.13428045 |
80 | Recurrent pneumonia (HP:0006532) | 2.11251665 |
81 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.10209828 |
82 | Cerebral hypomyelination (HP:0006808) | 2.09339461 |
83 | Abnormality of alanine metabolism (HP:0010916) | 2.09079948 |
84 | Hyperalaninemia (HP:0003348) | 2.09079948 |
85 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.09079948 |
86 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.06886229 |
87 | Absent thumb (HP:0009777) | 2.06807618 |
88 | Achilles tendon contracture (HP:0001771) | 2.06657145 |
89 | Pallor (HP:0000980) | 2.06156789 |
90 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.05814800 |
91 | Entropion (HP:0000621) | 2.04501215 |
92 | Dysphonia (HP:0001618) | 2.04451617 |
93 | Unsteady gait (HP:0002317) | 2.03529470 |
94 | Lymphoma (HP:0002665) | 2.03453630 |
95 | Hypoplasia of the pons (HP:0012110) | 2.02387554 |
96 | Cerebral edema (HP:0002181) | 2.01813938 |
97 | 3-Methylglutaconic aciduria (HP:0003535) | 2.01787418 |
98 | Carpal bone hypoplasia (HP:0001498) | 2.01650432 |
99 | Pulmonary fibrosis (HP:0002206) | 2.00804085 |
100 | Progressive external ophthalmoplegia (HP:0000590) | 1.99352033 |
101 | Hypothermia (HP:0002045) | 1.98584858 |
102 | Pancreatic cysts (HP:0001737) | 1.97176533 |
103 | Severe combined immunodeficiency (HP:0004430) | 1.96832620 |
104 | Oral leukoplakia (HP:0002745) | 1.96584726 |
105 | Nail dystrophy (HP:0008404) | 1.94934575 |
106 | Recurrent lower respiratory tract infections (HP:0002783) | 1.94711906 |
107 | Muscle stiffness (HP:0003552) | 1.94587680 |
108 | Thyroiditis (HP:0100646) | 1.93938029 |
109 | Pancreatic fibrosis (HP:0100732) | 1.93245574 |
110 | Overlapping toe (HP:0001845) | 1.93073396 |
111 | Microretrognathia (HP:0000308) | 1.92403911 |
112 | Meckel diverticulum (HP:0002245) | 1.91453620 |
113 | Pancytopenia (HP:0001876) | 1.88531965 |
114 | Leukodystrophy (HP:0002415) | 1.88095157 |
115 | Cellulitis (HP:0100658) | 1.87762519 |
116 | Seborrheic dermatitis (HP:0001051) | 1.85435254 |
117 | Emotional lability (HP:0000712) | 1.83693432 |
118 | Secondary amenorrhea (HP:0000869) | 1.82910759 |
119 | Abnormal protein glycosylation (HP:0012346) | 1.82595297 |
120 | Abnormal glycosylation (HP:0012345) | 1.82595297 |
121 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.82595297 |
122 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.82595297 |
123 | Progressive muscle weakness (HP:0003323) | 1.82028620 |
124 | Recurrent otitis media (HP:0000403) | 1.81529671 |
125 | Type 2 muscle fiber atrophy (HP:0003554) | 1.81459256 |
126 | Abnormality of the pons (HP:0007361) | 1.81395142 |
127 | Increased serum pyruvate (HP:0003542) | 1.80527739 |
128 | 11 pairs of ribs (HP:0000878) | 1.80275031 |
129 | Abnormality of the ileum (HP:0001549) | 1.80089210 |
130 | Deep palmar crease (HP:0006191) | 1.79754646 |
131 | Muscle fiber atrophy (HP:0100295) | 1.79732080 |
132 | Nephrogenic diabetes insipidus (HP:0009806) | 1.79575697 |
133 | Abnormality of T cells (HP:0002843) | 1.79433702 |
134 | Rhabdomyolysis (HP:0003201) | 1.78751356 |
135 | Focal motor seizures (HP:0011153) | 1.78320616 |
136 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 1.77664761 |
137 | Gout (HP:0001997) | 1.77663575 |
138 | Abnormal lung lobation (HP:0002101) | 1.77282245 |
139 | True hermaphroditism (HP:0010459) | 1.77043849 |
140 | Abnormality of T cell physiology (HP:0011840) | 1.76538204 |
141 | Reduced antithrombin III activity (HP:0001976) | 1.74945820 |
142 | Sensory axonal neuropathy (HP:0003390) | 1.73588656 |
143 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 1.72646541 |
144 | Death in infancy (HP:0001522) | 1.72051596 |
145 | Abnormality of glycolysis (HP:0004366) | 1.71362016 |
146 | Upper limb muscle weakness (HP:0003484) | 1.71228778 |
147 | Myopathic facies (HP:0002058) | 1.70790474 |
148 | Poikiloderma (HP:0001029) | 1.68689008 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BUB1 | 4.34444811 |
2 | EIF2AK1 | 4.27830369 |
3 | TLK1 | 2.79900948 |
4 | STK16 | 2.79050317 |
5 | EIF2AK3 | 2.78289230 |
6 | VRK2 | 2.69906876 |
7 | MAP4K1 | 2.57304262 |
8 | PLK4 | 2.55943238 |
9 | SRPK1 | 2.55229978 |
10 | NME2 | 2.54284510 |
11 | VRK1 | 2.19943554 |
12 | TAOK2 | 2.12266541 |
13 | WEE1 | 2.04414112 |
14 | CASK | 1.98318134 |
15 | SMG1 | 1.98295441 |
16 | BRAF | 1.90231006 |
17 | ARAF | 1.88528651 |
18 | NME1 | 1.87087337 |
19 | CDC7 | 1.81749649 |
20 | TESK2 | 1.75805470 |
21 | ERN1 | 1.72405360 |
22 | PRPF4B | 1.71595499 |
23 | CCNB1 | 1.71176696 |
24 | PBK | 1.67412936 |
25 | EPHA2 | 1.57685189 |
26 | ACVR1B | 1.47961958 |
27 | SYK | 1.47400465 |
28 | MUSK | 1.44073493 |
29 | MAP3K12 | 1.38283379 |
30 | IRAK3 | 1.35528189 |
31 | STK10 | 1.32944505 |
32 | MAP3K9 | 1.31580341 |
33 | LIMK1 | 1.27589898 |
34 | NEK1 | 1.21397222 |
35 | MST4 | 1.20548745 |
36 | CDK19 | 1.20440894 |
37 | IRAK4 | 1.16798926 |
38 | PLK1 | 1.15154006 |
39 | MAP3K8 | 1.14979673 |
40 | DYRK3 | 1.13374934 |
41 | ZAP70 | 1.11598016 |
42 | PAK4 | 1.10711579 |
43 | BLK | 1.09413041 |
44 | BMPR2 | 1.09062319 |
45 | GRK6 | 1.08951172 |
46 | AURKA | 1.08518555 |
47 | BRSK1 | 1.07743697 |
48 | MAP2K7 | 1.06980923 |
49 | LATS2 | 1.06774057 |
50 | TEC | 1.05102145 |
51 | PINK1 | 1.04911828 |
52 | BRSK2 | 1.02123457 |
53 | PRKCI | 1.00751707 |
54 | TRIB3 | 1.00513299 |
55 | TSSK6 | 0.99523591 |
56 | ALK | 0.99057327 |
57 | MAPKAPK3 | 0.98891002 |
58 | TBK1 | 0.96641183 |
59 | MAPK13 | 0.96155269 |
60 | NEK2 | 0.88635619 |
61 | MAP3K3 | 0.88158600 |
62 | STK38L | 0.87923190 |
63 | MKNK2 | 0.87119068 |
64 | ZAK | 0.85287129 |
65 | AURKB | 0.83668942 |
66 | CHEK2 | 0.82474390 |
67 | MAP3K14 | 0.82063768 |
68 | YES1 | 0.81701768 |
69 | ILK | 0.81667167 |
70 | ABL2 | 0.81261951 |
71 | TTK | 0.81066496 |
72 | CDK7 | 0.80515200 |
73 | PLK3 | 0.79862589 |
74 | SCYL2 | 0.79620268 |
75 | SIK1 | 0.79019076 |
76 | DYRK2 | 0.76858597 |
77 | BTK | 0.76831733 |
78 | TESK1 | 0.76066810 |
79 | CLK1 | 0.75751801 |
80 | ATR | 0.75657533 |
81 | NLK | 0.75052743 |
82 | MOS | 0.74549308 |
83 | TXK | 0.73921558 |
84 | MAP3K13 | 0.72339857 |
85 | LRRK2 | 0.71564382 |
86 | MAP3K10 | 0.70955518 |
87 | SIK3 | 0.70600425 |
88 | TNK2 | 0.70224314 |
89 | DAPK3 | 0.67977263 |
90 | TAOK1 | 0.67534650 |
91 | LYN | 0.67322055 |
92 | MKNK1 | 0.66986504 |
93 | MAP3K11 | 0.62079443 |
94 | PASK | 0.61659310 |
95 | PIM2 | 0.61532879 |
96 | RPS6KA4 | 0.60711453 |
97 | PIK3CG | 0.60358686 |
98 | MST1R | 0.58732640 |
99 | PAK1 | 0.58678077 |
100 | CSNK2A1 | 0.57742597 |
101 | MAP3K5 | 0.57260041 |
102 | DAPK1 | 0.57157211 |
103 | BCKDK | 0.54838656 |
104 | MAPK11 | 0.52381539 |
105 | RAF1 | 0.52291666 |
106 | CSNK2A2 | 0.50374537 |
107 | IRAK2 | 0.50087736 |
108 | KDR | 0.48787462 |
109 | RIPK4 | 0.48777315 |
110 | DMPK | 0.48463291 |
111 | STK24 | 0.48210139 |
112 | CDK11A | 0.47916152 |
113 | IKBKE | 0.45684322 |
114 | STK4 | 0.45078254 |
115 | PDK3 | 0.43537185 |
116 | PDK4 | 0.43537185 |
117 | RPS6KA5 | 0.42025389 |
118 | RPS6KB2 | 0.41841640 |
119 | EIF2AK2 | 0.40825251 |
120 | MAP3K1 | 0.40704554 |
121 | PIM1 | 0.40266451 |
122 | MAP2K3 | 0.40165785 |
123 | CHEK1 | 0.39452852 |
124 | CDK12 | 0.38367624 |
125 | PLK2 | 0.36180362 |
126 | CDK8 | 0.35726589 |
127 | CDK14 | 0.35605018 |
128 | IRAK1 | 0.35214326 |
129 | AKT2 | 0.34725970 |
130 | MARK3 | 0.34708266 |
131 | PRKCQ | 0.34494841 |
132 | PDK2 | 0.33094934 |
133 | PRKCH | 0.32917338 |
134 | CDK4 | 0.31692819 |
135 | CDK15 | 0.31626569 |
136 | TAF1 | 0.31562962 |
137 | CSNK1G3 | 0.31530780 |
138 | ADRBK2 | 0.30184584 |
139 | IKBKB | 0.27137678 |
140 | CSNK1G1 | 0.26227967 |
141 | OBSCN | 0.25539010 |
142 | CSF1R | 0.24578960 |
143 | LCK | 0.23791883 |
144 | HIPK2 | 0.23081470 |
145 | PRKCG | 0.22733604 |
Rank | Gene Set | Z-score |
---|---|---|
1 | DNA replication_Homo sapiens_hsa03030 | 4.02024505 |
2 | Ribosome_Homo sapiens_hsa03010 | 4.01364808 |
3 | Proteasome_Homo sapiens_hsa03050 | 3.92543457 |
4 | Mismatch repair_Homo sapiens_hsa03430 | 3.69037498 |
5 | RNA polymerase_Homo sapiens_hsa03020 | 3.21801275 |
6 | Homologous recombination_Homo sapiens_hsa03440 | 3.13704219 |
7 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.03094360 |
8 | Base excision repair_Homo sapiens_hsa03410 | 2.91214049 |
9 | Parkinsons disease_Homo sapiens_hsa05012 | 2.85375498 |
10 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.62672238 |
11 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.61488386 |
12 | Protein export_Homo sapiens_hsa03060 | 2.56153071 |
13 | Spliceosome_Homo sapiens_hsa03040 | 2.55151089 |
14 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.42019099 |
15 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.41999807 |
16 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.23349365 |
17 | Huntingtons disease_Homo sapiens_hsa05016 | 2.19189839 |
18 | Alzheimers disease_Homo sapiens_hsa05010 | 1.93998969 |
19 | Basal transcription factors_Homo sapiens_hsa03022 | 1.90611644 |
20 | RNA transport_Homo sapiens_hsa03013 | 1.88495408 |
21 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.75713497 |
22 | Cell cycle_Homo sapiens_hsa04110 | 1.68418824 |
23 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.61766294 |
24 | RNA degradation_Homo sapiens_hsa03018 | 1.54210284 |
25 | Purine metabolism_Homo sapiens_hsa00230 | 1.51492610 |
26 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.40492252 |
27 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.12218831 |
28 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.11492187 |
29 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.11383368 |
30 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.06343652 |
31 | Viral myocarditis_Homo sapiens_hsa05416 | 1.05981427 |
32 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.04855785 |
33 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.99995928 |
34 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.99837336 |
35 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.96434200 |
36 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.95778641 |
37 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.94794919 |
38 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.94295908 |
39 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.88768063 |
40 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.87057979 |
41 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.86758441 |
42 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.84955179 |
43 | Bladder cancer_Homo sapiens_hsa05219 | 0.82225474 |
44 | Carbon metabolism_Homo sapiens_hsa01200 | 0.77045773 |
45 | Prion diseases_Homo sapiens_hsa05020 | 0.72729541 |
46 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.72593245 |
47 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.71928755 |
48 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.71418076 |
49 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.68926049 |
50 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.68509206 |
51 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.68222529 |
52 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.67604197 |
53 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.67005058 |
54 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.60195693 |
55 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.59898912 |
56 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.59017570 |
57 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.58540769 |
58 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.58170624 |
59 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.56649433 |
60 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.55006883 |
61 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.53474544 |
62 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.53403887 |
63 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.52696228 |
64 | Olfactory transduction_Homo sapiens_hsa04740 | 0.51172876 |
65 | Alcoholism_Homo sapiens_hsa05034 | 0.50201201 |
66 | Other glycan degradation_Homo sapiens_hsa00511 | 0.49714398 |
67 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.48002277 |
68 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.47579243 |
69 | * Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.47040391 |
70 | Measles_Homo sapiens_hsa05162 | 0.46454638 |
71 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.46043335 |
72 | Galactose metabolism_Homo sapiens_hsa00052 | 0.43822948 |
73 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.42098166 |
74 | Metabolic pathways_Homo sapiens_hsa01100 | 0.41965657 |
75 | * Salmonella infection_Homo sapiens_hsa05132 | 0.41261324 |
76 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.39979053 |
77 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.39132529 |
78 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.38459924 |
79 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.35880245 |
80 | * Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.35371701 |
81 | HTLV-I infection_Homo sapiens_hsa05166 | 0.34719625 |
82 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.34232470 |
83 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.33302753 |
84 | Sulfur relay system_Homo sapiens_hsa04122 | 0.33017842 |
85 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.32161567 |
86 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.32084699 |
87 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.31744012 |
88 | Thyroid cancer_Homo sapiens_hsa05216 | 0.31245934 |
89 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.31074107 |
90 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.30139072 |
91 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.29723881 |
92 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.29720811 |
93 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.29591186 |
94 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.29266839 |
95 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.29063662 |
96 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.27600123 |
97 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.26610769 |
98 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.26272909 |
99 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.25439828 |
100 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.25281074 |
101 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.23821972 |
102 | Long-term potentiation_Homo sapiens_hsa04720 | 0.23605624 |
103 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.22085038 |
104 | * Shigellosis_Homo sapiens_hsa05131 | 0.21819058 |
105 | Allograft rejection_Homo sapiens_hsa05330 | 0.19385215 |
106 | Phototransduction_Homo sapiens_hsa04744 | 0.18928926 |
107 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.18046535 |
108 | Taste transduction_Homo sapiens_hsa04742 | 0.17996961 |
109 | Influenza A_Homo sapiens_hsa05164 | 0.17933618 |
110 | Nicotine addiction_Homo sapiens_hsa05033 | 0.15507072 |
111 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.13644226 |
112 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.13375187 |
113 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.12592357 |
114 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.12463068 |
115 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.11749238 |
116 | Hepatitis B_Homo sapiens_hsa05161 | 0.11406972 |
117 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.11308707 |
118 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.10958950 |
119 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.10327127 |
120 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.09726217 |
121 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.08980333 |
122 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.08113067 |
123 | Asthma_Homo sapiens_hsa05310 | 0.07985679 |
124 | Apoptosis_Homo sapiens_hsa04210 | 0.07232514 |
125 | * Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.05852755 |
126 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.05213868 |
127 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.05109266 |
128 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.04970910 |