ARPIN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.30500108
2COPI coating of Golgi vesicle (GO:0048205)4.30500108
3behavioral response to nicotine (GO:0035095)3.64761246
4cellular response to vitamin D (GO:0071305)3.61489681
5growth hormone receptor signaling pathway (GO:0060396)3.27792486
6maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.27012036
7bundle of His cell to Purkinje myocyte communication (GO:0086069)3.23810596
8negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.11927953
9cellular response to vitamin (GO:0071295)3.09126705
10hemidesmosome assembly (GO:0031581)3.05843718
11retina vasculature morphogenesis in camera-type eye (GO:0061299)3.04603085
12regulation of hippo signaling (GO:0035330)2.97302233
13negative regulation of cytosolic calcium ion concentration (GO:0051481)2.97024929
14protein retention in ER lumen (GO:0006621)2.95219515
15peptidyl-tyrosine autophosphorylation (GO:0038083)2.93132552
16adhesion of symbiont to host cell (GO:0044650)2.91782039
17virion attachment to host cell (GO:0019062)2.91782039
18desmosome organization (GO:0002934)2.90752364
19phosphatidylinositol acyl-chain remodeling (GO:0036149)2.90468667
20drug catabolic process (GO:0042737)2.82539955
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.81527833
22fucose catabolic process (GO:0019317)2.80358337
23L-fucose metabolic process (GO:0042354)2.80358337
24L-fucose catabolic process (GO:0042355)2.80358337
25cellular response to growth hormone stimulus (GO:0071378)2.80265678
26collagen fibril organization (GO:0030199)2.79882338
27actin filament depolymerization (GO:0030042)2.79337813
28positive regulation of fatty acid oxidation (GO:0046321)2.78813444
29exogenous drug catabolic process (GO:0042738)2.72882296
30positive regulation of fatty acid beta-oxidation (GO:0032000)2.72229010
31indole-containing compound catabolic process (GO:0042436)2.71665253
32indolalkylamine catabolic process (GO:0046218)2.71665253
33tryptophan catabolic process (GO:0006569)2.71665253
34chondrocyte proliferation (GO:0035988)2.69845184
35phosphatidylserine acyl-chain remodeling (GO:0036150)2.66904924
36sulfation (GO:0051923)2.65201161
37cell adhesion mediated by integrin (GO:0033627)2.63742431
38regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.62748609
39macroautophagy (GO:0016236)2.62435679
40retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.62048035
41detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.61340087
42response to prostaglandin E (GO:0034695)2.58256946
43intestinal absorption (GO:0050892)2.58095545
44kynurenine metabolic process (GO:0070189)2.55910695
45regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.55317630
46ketone body metabolic process (GO:1902224)2.55141114
47regulation of integrin-mediated signaling pathway (GO:2001044)2.54524136
48response to pheromone (GO:0019236)2.53928547
49regulation of type B pancreatic cell apoptotic process (GO:2000674)2.50645186
50peptide hormone processing (GO:0016486)2.49157684
51indolalkylamine metabolic process (GO:0006586)2.48766103
52sequestering of metal ion (GO:0051238)2.48027053
53positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.45547758
54positive regulation of sodium ion transmembrane transport (GO:1902307)2.45505397
55proline transport (GO:0015824)2.44909415
56protein import into peroxisome matrix (GO:0016558)2.44430978
57protein heterotrimerization (GO:0070208)2.44038580
58positive regulation of vesicle fusion (GO:0031340)2.41313357
59cellular response to prostaglandin stimulus (GO:0071379)2.41239732
60membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.41182053
61vascular endothelial growth factor signaling pathway (GO:0038084)2.40763957
62cAMP catabolic process (GO:0006198)2.40237430
63stress fiber assembly (GO:0043149)2.39989352
64negative regulation of leukocyte chemotaxis (GO:0002689)2.39442312
65cellular response to nutrient (GO:0031670)2.39331894
66toxin metabolic process (GO:0009404)2.38725619
67protein maturation by protein folding (GO:0022417)2.37781600
68phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.37779332
69gamma-aminobutyric acid transport (GO:0015812)2.35792249
70appendage development (GO:0048736)2.35791554
71limb development (GO:0060173)2.35791554
72regulation of guanylate cyclase activity (GO:0031282)2.35429471
73mesenchyme morphogenesis (GO:0072132)2.35418320
74nucleobase catabolic process (GO:0046113)2.35132754
75endocardial cushion morphogenesis (GO:0003203)2.34609814
76membrane budding (GO:0006900)2.33748197
77negative regulation of protein localization to cell surface (GO:2000009)2.33269523
78plasma membrane repair (GO:0001778)2.33180849
79epithelial cell-cell adhesion (GO:0090136)2.32741346
80membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.32317118
81inner ear receptor stereocilium organization (GO:0060122)2.31789560
82wound healing, spreading of epidermal cells (GO:0035313)2.31779303
83keratinocyte proliferation (GO:0043616)2.30829514
84serotonin metabolic process (GO:0042428)2.30275779
85ganglion development (GO:0061548)2.28827814
86endothelial cell morphogenesis (GO:0001886)2.28487804
87neuron projection extension involved in neuron projection guidance (GO:1902284)2.27802310
88axon extension involved in axon guidance (GO:0048846)2.27802310
89behavioral response to ethanol (GO:0048149)2.27129158
90sulfate transport (GO:0008272)2.27082984
91primary amino compound metabolic process (GO:1901160)2.26963052
923-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.26836496
93purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.26836496
94glomerular filtration (GO:0003094)2.26168086
95negative regulation of mast cell activation (GO:0033004)2.26093212
96regulation of secondary heart field cardioblast proliferation (GO:0003266)2.25931971
97regulation of cardioblast proliferation (GO:0003264)2.25931971
98metanephric mesenchyme development (GO:0072075)2.25178216
99adhesion of symbiont to host (GO:0044406)2.24865131
100vitamin A metabolic process (GO:0006776)2.24617501
101cornea development in camera-type eye (GO:0061303)2.24399031
102cyclic nucleotide catabolic process (GO:0009214)2.24300662
103phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.24048430
104negative regulation of synaptic transmission, GABAergic (GO:0032229)2.22730316
105positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.21567545
106nonmotile primary cilium assembly (GO:0035058)2.21042881
107response to prostaglandin (GO:0034694)2.20727740
108negative regulation of keratinocyte proliferation (GO:0010839)2.20365194
109thyroid hormone metabolic process (GO:0042403)2.20053077
110positive regulation of guanylate cyclase activity (GO:0031284)2.19385244
111neuronal action potential (GO:0019228)2.18445344
112skin morphogenesis (GO:0043589)2.18064878
113arginine metabolic process (GO:0006525)2.17471479
114lung vasculature development (GO:0060426)2.16759866
115positive regulation of endothelial cell apoptotic process (GO:2000353)2.16614007
116arginine catabolic process (GO:0006527)2.15875620
117regulation of neurotransmitter uptake (GO:0051580)2.15458930
118neural crest cell development (GO:0014032)2.15405326
119neurotransmitter metabolic process (GO:0042133)2.15271549
120vascular smooth muscle contraction (GO:0014829)2.14665639
121sulfate transmembrane transport (GO:1902358)2.14277603
122regulation of energy homeostasis (GO:2000505)2.14261431
123nephron epithelium morphogenesis (GO:0072088)2.13845083
124nephron tubule morphogenesis (GO:0072078)2.13845083
125flavonoid metabolic process (GO:0009812)2.13783161
126water-soluble vitamin biosynthetic process (GO:0042364)2.11759498
127positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.11453132
128negative regulation of axon guidance (GO:1902668)2.11427409
129cellular copper ion homeostasis (GO:0006878)2.11047666
130indole-containing compound metabolic process (GO:0042430)2.11018957
131postsynaptic membrane organization (GO:0001941)2.10954071
132tryptophan metabolic process (GO:0006568)2.10849022
133alanine transport (GO:0032328)2.10757984
134COPII vesicle coating (GO:0048208)2.10661973
135cell communication involved in cardiac conduction (GO:0086065)2.10535504
136peptidyl-proline hydroxylation (GO:0019511)2.09943036
137kidney morphogenesis (GO:0060993)2.09915299
138regulation of axon guidance (GO:1902667)2.09821834
139regulation of metalloenzyme activity (GO:0048552)2.09790822
140import into cell (GO:0098657)2.09703181
141membrane depolarization during action potential (GO:0086010)2.09191377
142regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.09042580
143regulation of heart rate by cardiac conduction (GO:0086091)2.08826030
144cilium or flagellum-dependent cell motility (GO:0001539)2.08591850
145membrane repolarization during action potential (GO:0086011)2.08478128
146smooth muscle tissue development (GO:0048745)2.08174334
147transepithelial transport (GO:0070633)2.08008888
148kidney mesenchyme development (GO:0072074)2.07987412
149smooth muscle contraction (GO:0006939)2.07211062
150auditory receptor cell differentiation (GO:0042491)2.07060314
151pyrimidine nucleobase catabolic process (GO:0006208)2.06521163
152cellular ketone body metabolic process (GO:0046950)2.06260406
153regulation of non-canonical Wnt signaling pathway (GO:2000050)2.05994344
154sequestering of extracellular ligand from receptor (GO:0035581)2.04990521
155regulation of axon extension involved in axon guidance (GO:0048841)2.04432837
156reflex (GO:0060004)2.03145003
157negative regulation of axon extension involved in axon guidance (GO:0048843)2.02802541
158cellular response to hepatocyte growth factor stimulus (GO:0035729)2.02792521
159response to hepatocyte growth factor (GO:0035728)2.02792521
160phosphatidylcholine acyl-chain remodeling (GO:0036151)2.02004476
161cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.01750718
162regulation of action potential (GO:0098900)2.01736457
163regulation of pigment cell differentiation (GO:0050932)2.01072442
164intestinal cholesterol absorption (GO:0030299)2.00907573
165regulation of cGMP metabolic process (GO:0030823)2.00824318
166regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.00628354
167regulation of membrane protein ectodomain proteolysis (GO:0051043)2.00249378
168inner ear receptor cell development (GO:0060119)2.00229671
169positive regulation of glycolytic process (GO:0045821)2.00093290
170glomerular basement membrane development (GO:0032836)1.99377485
171renal filtration (GO:0097205)1.99264370
172regulation of cardioblast differentiation (GO:0051890)1.99173544
173startle response (GO:0001964)1.98841471
174action potential (GO:0001508)1.98172260
175positive regulation of membrane protein ectodomain proteolysis (GO:0051044)1.97670809
176cellular response to ATP (GO:0071318)1.97276451
177nitric oxide biosynthetic process (GO:0006809)1.97184945
178positive regulation of pseudopodium assembly (GO:0031274)1.96123734
179regulation of tight junction assembly (GO:2000810)1.95550504
180eosinophil chemotaxis (GO:0048245)1.94907615
181cell migration involved in heart development (GO:0060973)1.94336730
182endocrine pancreas development (GO:0031018)1.93856146
183tight junction assembly (GO:0070830)1.93707399
184lymphangiogenesis (GO:0001946)1.93305830
185ventricular cardiac muscle cell action potential (GO:0086005)1.92883623
186extracellular matrix assembly (GO:0085029)1.91928760
187lymph vessel development (GO:0001945)1.91285407
188activation of signaling protein activity involved in unfolded protein response (GO:0006987)1.91237802
189negative regulation of cation channel activity (GO:2001258)1.90244905
190regulation of calcineurin-NFAT signaling cascade (GO:0070884)1.90147682

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.41007319
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.48560898
3RARG_19884340_ChIP-ChIP_MEFs_Mouse2.85617956
4EZH2_22144423_ChIP-Seq_EOC_Human2.67787945
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.56779790
6GBX2_23144817_ChIP-Seq_PC3_Human2.55254937
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.53803927
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.48730427
9CLOCK_20551151_ChIP-Seq_293T_Human2.43965314
10VDR_22108803_ChIP-Seq_LS180_Human2.43365897
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.29474038
12ZNF274_21170338_ChIP-Seq_K562_Hela2.26335084
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17194532
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.13202967
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.09106983
16SOX2_20726797_ChIP-Seq_SW620_Human2.08205239
17ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.04994866
18NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.01281950
19NRF2_20460467_ChIP-Seq_MEFs_Mouse2.01281950
20WT1_19549856_ChIP-ChIP_CCG9911_Human2.01121227
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.00217938
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93043674
23CJUN_26792858_Chip-Seq_BT549_Human1.89572470
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.85033490
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84348035
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.83036101
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.82753345
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81800469
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75350556
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.70107217
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67649640
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67104470
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.67094552
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66569168
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63645500
36DROSHA_22980978_ChIP-Seq_HELA_Human1.62576380
37NR3C1_21868756_ChIP-Seq_MCF10A_Human1.60816902
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59135571
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57590017
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57083036
41RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57083036
42TP53_16413492_ChIP-PET_HCT116_Human1.56290477
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55416420
44P300_19829295_ChIP-Seq_ESCs_Human1.53448418
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.52879791
46SMAD4_21799915_ChIP-Seq_A2780_Human1.51372134
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49640464
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49417291
49SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.47699424
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.46987896
51TAF15_26573619_Chip-Seq_HEK293_Human1.46718339
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.46573117
53SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.46573117
54AR_25329375_ChIP-Seq_VCAP_Human1.44945627
55BCAT_22108803_ChIP-Seq_LS180_Human1.44851730
56STAT3_23295773_ChIP-Seq_U87_Human1.43552712
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43338155
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41848560
59CDX2_20551321_ChIP-Seq_CACO-2_Human1.41088851
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40282961
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39821287
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.39219517
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38875492
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38309360
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.37721135
66FUS_26573619_Chip-Seq_HEK293_Human1.35547135
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.35542845
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.35015838
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34218129
70ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33296542
71IGF1R_20145208_ChIP-Seq_DFB_Human1.30872953
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.29851854
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29133962
74SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29081355
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28616975
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28407390
77EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28129662
78CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27387710
79TCF4_23295773_ChIP-Seq_U87_Human1.27196017
80TP53_18474530_ChIP-ChIP_U2OS_Human1.26126283
81ER_23166858_ChIP-Seq_MCF-7_Human1.25867583
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.25377667
83JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24702395
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24446699
85SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23786049
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23687606
87TCF4_22108803_ChIP-Seq_LS180_Human1.23164461
88BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21389193
89PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21355721
90GATA4_25053715_ChIP-Seq_YYC3_Human1.21333552
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21322523
92ESR2_21235772_ChIP-Seq_MCF-7_Human1.21260283
93ESR1_20079471_ChIP-ChIP_T-47D_Human1.20737645
94REST_21632747_ChIP-Seq_MESCs_Mouse1.20524672
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20323615
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20323615
97AR_21572438_ChIP-Seq_LNCaP_Human1.19601141
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18505013
99EZH2_27294783_Chip-Seq_ESCs_Mouse1.18364062
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17084556
101SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16804282
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14947364
103FLI1_27457419_Chip-Seq_LIVER_Mouse1.14613489
104EWS_26573619_Chip-Seq_HEK293_Human1.14450814
105TP53_20018659_ChIP-ChIP_R1E_Mouse1.12769308
106CBP_20019798_ChIP-Seq_JUKART_Human1.12222656
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12222656
108SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12030533
109PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11832133
110JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11241703
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10142557
112ZNF263_19887448_ChIP-Seq_K562_Human1.08938974
113JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08548128
114RUNX2_22187159_ChIP-Seq_PCA_Human1.08450900
115SMAD4_21741376_ChIP-Seq_EPCs_Human1.07577985
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07277979
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07126110
118SOX2_21211035_ChIP-Seq_LN229_Gbm1.06174375
119ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04577963
120SMAD4_21741376_ChIP-Seq_HESCs_Human1.04387037
121BRD4_25478319_ChIP-Seq_HGPS_Human1.03463543
122CDX2_22108803_ChIP-Seq_LS180_Human1.03042240
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02754873
124SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02439192
125RNF2_27304074_Chip-Seq_ESCs_Mouse1.02412119
126TBX20_22328084_ChIP-Seq_HEART_Mouse1.01626809
127TBX20_22080862_ChIP-Seq_HEART_Mouse1.01626809
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00737271
129RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00111193
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99837473
131NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98842320
132RXR_22108803_ChIP-Seq_LS180_Human0.98106300
133CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98084567
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98028409
135CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97962966
136FOXO3_23340844_ChIP-Seq_DLD1_Human0.97593781
137KLF5_25053715_ChIP-Seq_YYC3_Human0.97577978
138SMAD3_21741376_ChIP-Seq_HESCs_Human0.97134121
139TP63_23658742_ChIP-Seq_EP156T_Human0.97018739
140HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94761315
141WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94435081
142SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94372896
143TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93000116
144PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92917872
145WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92784599
146AHR_22903824_ChIP-Seq_MCF-7_Human0.92742550
147AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92615435
148FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91475616
149SMC1_22415368_ChIP-Seq_MEFs_Mouse0.90242693
150TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88453815
151NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88273136
152FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88115442
153TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86476963
154KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86290856
155TCF4_18268006_ChIP-ChIP_LS174T_Human0.85167302
156OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83834965
157ISL1_27105846_Chip-Seq_CPCs_Mouse0.83271871
158P63_26484246_Chip-Seq_KERATINOCYTES_Human0.83128672
159ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82907549

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.22944213
2MP0002877_abnormal_melanocyte_morpholog3.04099042
3MP0004272_abnormal_basement_membrane2.97206878
4MP0005275_abnormal_skin_tensile2.89554883
5MP0003705_abnormal_hypodermis_morpholog2.86964416
6MP0001346_abnormal_lacrimal_gland2.80160064
7MP0000569_abnormal_digit_pigmentation2.77682313
8MP0002138_abnormal_hepatobiliary_system2.67588581
9MP0002254_reproductive_system_inflammat2.65093306
10MP0010386_abnormal_urinary_bladder2.54282230
11MP0000566_synostosis2.49112578
12MP0005623_abnormal_meninges_morphology2.43069697
13MP0005503_abnormal_tendon_morphology2.32419228
14MP0001501_abnormal_sleep_pattern2.29964612
15MP0000013_abnormal_adipose_tissue2.23273893
16MP0001348_abnormal_lacrimal_gland2.18718305
17MP0001879_abnormal_lymphatic_vessel2.15642335
18MP0003195_calcinosis2.13913559
19MP0010030_abnormal_orbit_morphology2.11909050
20MP0002009_preneoplasia2.06434926
21MP0005551_abnormal_eye_electrophysiolog2.01480311
22MP0009780_abnormal_chondrocyte_physiolo1.99782895
23MP0003136_yellow_coat_color1.94405629
24MP0002163_abnormal_gland_morphology1.92213922
25MP0005167_abnormal_blood-brain_barrier1.88705448
26MP0003646_muscle_fatigue1.88309111
27MP0009379_abnormal_foot_pigmentation1.82495752
28MP0001958_emphysema1.80503366
29MP0005084_abnormal_gallbladder_morpholo1.72253096
30MP0004858_abnormal_nervous_system1.72100337
31MP0004885_abnormal_endolymph1.71810486
32MP0003566_abnormal_cell_adhesion1.71762781
33MP0009384_cardiac_valve_regurgitation1.70174003
34MP0000427_abnormal_hair_cycle1.69809131
35MP0002938_white_spotting1.68499149
36MP0003283_abnormal_digestive_organ1.66166853
37MP0000383_abnormal_hair_follicle1.66124560
38MP0003279_aneurysm1.64585363
39MP0005365_abnormal_bile_salt1.64259395
40MP0002295_abnormal_pulmonary_circulatio1.61337871
41MP0003091_abnormal_cell_migration1.60214416
42MP0001485_abnormal_pinna_reflex1.54061246
43MP0005174_abnormal_tail_pigmentation1.52453720
44MP0002837_dystrophic_cardiac_calcinosis1.50404642
45MP0005085_abnormal_gallbladder_physiolo1.47975857
46MP0010678_abnormal_skin_adnexa1.45993146
47MP0002896_abnormal_bone_mineralization1.44955581
48MP0010368_abnormal_lymphatic_system1.44521018
49MP0002060_abnormal_skin_morphology1.43806691
50MP0002102_abnormal_ear_morphology1.40061727
51MP0000516_abnormal_urinary_system1.37261356
52MP0005367_renal/urinary_system_phenotyp1.37261356
53MP0000537_abnormal_urethra_morphology1.37072360
54MP0001664_abnormal_digestion1.35782492
55MP0010234_abnormal_vibrissa_follicle1.34303336
56MP0005379_endocrine/exocrine_gland_phen1.33239925
57MP0008875_abnormal_xenobiotic_pharmacok1.31669146
58MP0000538_abnormal_urinary_bladder1.31210504
59MP0003300_gastrointestinal_ulcer1.30728105
60MP0000462_abnormal_digestive_system1.28742790
61MP0004215_abnormal_myocardial_fiber1.28344810
62MP0010329_abnormal_lipoprotein_level1.26217009
63MP0003941_abnormal_skin_development1.24616244
64MP0001299_abnormal_eye_distance/1.23948434
65MP0009745_abnormal_behavioral_response1.23180710
66MP0004043_abnormal_pH_regulation1.23068296
67MP0009250_abnormal_appendicular_skeleto1.21015583
68MP0005646_abnormal_pituitary_gland1.20794233
69MP0004084_abnormal_cardiac_muscle1.19956658
70MP0000631_abnormal_neuroendocrine_gland1.19829349
71MP0002272_abnormal_nervous_system1.19137035
72MP0001756_abnormal_urination1.18000651
73MP0003252_abnormal_bile_duct1.17999622
74MP0003122_maternal_imprinting1.16111629
75MP0002909_abnormal_adrenal_gland1.15927049
76MP0005670_abnormal_white_adipose1.14437647
77MP0003011_delayed_dark_adaptation1.14422806
78MP0000534_abnormal_ureter_morphology1.14213898
79MP0004130_abnormal_muscle_cell1.13710297
80MP0001984_abnormal_olfaction1.12704746
81MP0000613_abnormal_salivary_gland1.12336534
82MP0005508_abnormal_skeleton_morphology1.11943491
83MP0000678_abnormal_parathyroid_gland1.10015327
84MP0002876_abnormal_thyroid_physiology1.09800871
85MP0002064_seizures1.09097126
86MP0002557_abnormal_social/conspecific_i1.08926350
87MP0004133_heterotaxia1.07414606
88MP0009046_muscle_twitch1.07166750
89MP0004264_abnormal_extraembryonic_tissu1.06692175
90MP0001968_abnormal_touch/_nociception1.05355781
91MP0001486_abnormal_startle_reflex1.04205081
92MP0002638_abnormal_pupillary_reflex1.03865097
93MP0004019_abnormal_vitamin_homeostasis1.03807221
94MP0003879_abnormal_hair_cell1.03671595
95MP0005257_abnormal_intraocular_pressure1.03613456
96MP0002234_abnormal_pharynx_morphology1.03564773
97MP0005595_abnormal_vascular_smooth1.02915296
98MP0005645_abnormal_hypothalamus_physiol1.02137138
99MP0002572_abnormal_emotion/affect_behav1.01494168
100MP0006138_congestive_heart_failure1.01369537
101MP0004085_abnormal_heartbeat1.01338196
102MP0000778_abnormal_nervous_system1.01272467
103MP0006054_spinal_hemorrhage1.01182474
104MP0003385_abnormal_body_wall1.00894151
105MP0003045_fibrosis1.00843335
106MP0002928_abnormal_bile_duct1.00730053
107MP0002653_abnormal_ependyma_morphology1.00618228
108MP0009053_abnormal_anal_canal1.00296646
109MP0000026_abnormal_inner_ear1.00265885
110MP0001765_abnormal_ion_homeostasis0.99979918
111MP0008872_abnormal_physiological_respon0.99526064
112MP0002972_abnormal_cardiac_muscle0.99038187
113MP0005220_abnormal_exocrine_pancreas0.98923573
114MP0001986_abnormal_taste_sensitivity0.98891998
115MP0005332_abnormal_amino_acid0.98164404
116MP0001542_abnormal_bone_strength0.98120151
117MP0003137_abnormal_impulse_conducting0.96079724
118MP0003937_abnormal_limbs/digits/tail_de0.95704728
119MP0001270_distended_abdomen0.94133240
120MP0000163_abnormal_cartilage_morphology0.93860030
121MP0001970_abnormal_pain_threshold0.93548142
122MP0005253_abnormal_eye_physiology0.92582274
123MP0000749_muscle_degeneration0.92001200
124MP0000230_abnormal_systemic_arterial0.91856704
125MP0002090_abnormal_vision0.91301210
126MP0001944_abnormal_pancreas_morphology0.89632165
127MP0005386_behavior/neurological_phenoty0.88662350
128MP0004924_abnormal_behavior0.88662350
129MP0004484_altered_response_of0.88613717
130MP0004782_abnormal_surfactant_physiolog0.88581152
131MP0000003_abnormal_adipose_tissue0.88576127
132MP0002733_abnormal_thermal_nociception0.88233768
133MP0001502_abnormal_circadian_rhythm0.87938287
134MP0001243_abnormal_dermal_layer0.87933427
135MP0004147_increased_porphyrin_level0.87420122
136MP0003453_abnormal_keratinocyte_physiol0.86860838
137MP0002277_abnormal_respiratory_mucosa0.86801800
138MP0000751_myopathy0.86534476
139MP0005248_abnormal_Harderian_gland0.86509908
140MP0005076_abnormal_cell_differentiation0.84958466
141MP0005360_urolithiasis0.84349960
142MP0005171_absent_coat_pigmentation0.83052707
143MP0008004_abnormal_stomach_pH0.81451296
144MP0005195_abnormal_posterior_eye0.80319433
145MP0000467_abnormal_esophagus_morphology0.80081541
146MP0004510_myositis0.78315394
147MP0005187_abnormal_penis_morphology0.78037736
148MP0004145_abnormal_muscle_electrophysio0.77770517
149MP0004142_abnormal_muscle_tone0.77303649
150MP0003632_abnormal_nervous_system0.76007489
151MP0005165_increased_susceptibility_to0.75970050
152MP0001666_abnormal_nutrient_absorption0.75869803
153MP0003119_abnormal_digestive_system0.75696642
154MP0005448_abnormal_energy_balance0.75407221
155MP0000762_abnormal_tongue_morphology0.75108942
156MP0002063_abnormal_learning/memory/cond0.74895176
157MP0002166_altered_tumor_susceptibility0.73457491
158MP0003950_abnormal_plasma_membrane0.73136203
159MP0000049_abnormal_middle_ear0.73100474
160MP0002796_impaired_skin_barrier0.72586216
161MP0010352_gastrointestinal_tract_polyps0.72137882
162MP0001324_abnormal_eye_pigmentation0.72027905
163MP0009643_abnormal_urine_homeostasis0.72007661
164MP0005620_abnormal_muscle_contractility0.71696083
165MP0002115_abnormal_skeleton_extremities0.71641339
166MP0002108_abnormal_muscle_morphology0.71373295
167MP0005023_abnormal_wound_healing0.69715807
168MP0008775_abnormal_heart_ventricle0.69297650
169MP0000767_abnormal_smooth_muscle0.67432932
170MP0003183_abnormal_peptide_metabolism0.67389397

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.20545854
2Tubular atrophy (HP:0000092)4.36956663
3Protrusio acetabuli (HP:0003179)4.08223036
4Hyperventilation (HP:0002883)4.03211983
5Right ventricular cardiomyopathy (HP:0011663)3.99823364
6Atrophic scars (HP:0001075)3.76261121
7Pancreatic cysts (HP:0001737)3.68273179
8Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.49312986
9Decreased circulating renin level (HP:0003351)3.30471663
10Abnormality of the renal cortex (HP:0011035)3.28051092
11Abnormality of dentin (HP:0010299)3.24840348
12Congenital stationary night blindness (HP:0007642)3.22455412
13Fragile skin (HP:0001030)3.17775275
14Nephronophthisis (HP:0000090)3.17210709
15Pancreatic fibrosis (HP:0100732)3.14043291
16Polydipsia (HP:0001959)3.12891251
17Abnormal drinking behavior (HP:0030082)3.12891251
18Peritonitis (HP:0002586)3.12869324
19True hermaphroditism (HP:0010459)3.08418853
20Neonatal short-limb short stature (HP:0008921)3.05433856
21Type II lissencephaly (HP:0007260)2.99783345
22Molar tooth sign on MRI (HP:0002419)2.96810113
23Abnormality of midbrain morphology (HP:0002418)2.96810113
24Abnormality of the renal medulla (HP:0100957)2.96188923
25Genetic anticipation (HP:0003743)2.83999761
26Vertebral compression fractures (HP:0002953)2.82976458
27Keratoconus (HP:0000563)2.82086477
28Increased corneal curvature (HP:0100692)2.82086477
29Thin bony cortex (HP:0002753)2.78716933
30Hydroxyprolinuria (HP:0003080)2.76626119
31Abnormality of proline metabolism (HP:0010907)2.76626119
32Aortic dissection (HP:0002647)2.74602261
33Tubulointerstitial fibrosis (HP:0005576)2.70264610
34Soft skin (HP:0000977)2.64698429
35Progressive inability to walk (HP:0002505)2.61753617
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.60907828
37Abnormality of alanine metabolism (HP:0010916)2.60907828
38Hyperalaninemia (HP:0003348)2.60907828
39Cystic liver disease (HP:0006706)2.59287701
40Mildly elevated creatine phosphokinase (HP:0008180)2.57609296
41Hypoglycemic coma (HP:0001325)2.54107988
42Hypercortisolism (HP:0001578)2.54017771
43Congenital, generalized hypertrichosis (HP:0004540)2.53960558
44Wormian bones (HP:0002645)2.52176099
45Nuclear cataract (HP:0100018)2.50792891
46Symptomatic seizures (HP:0011145)2.50399555
47Broad metatarsal (HP:0001783)2.47479795
48Inability to walk (HP:0002540)2.46850328
49Hyperparathyroidism (HP:0000843)2.45657323
50Chorioretinal atrophy (HP:0000533)2.45255562
51Spinal rigidity (HP:0003306)2.43713702
52Aplasia involving bones of the extremities (HP:0009825)2.43594598
53Aplasia involving bones of the upper limbs (HP:0009823)2.43594598
54Aplasia of the phalanges of the hand (HP:0009802)2.43594598
55Medial flaring of the eyebrow (HP:0010747)2.42809926
56Short nail (HP:0001799)2.40422879
57Aortic aneurysm (HP:0004942)2.39748369
58Progressive cerebellar ataxia (HP:0002073)2.39334156
59Large for gestational age (HP:0001520)2.38755033
60Abnormality of renin-angiotensin system (HP:0000847)2.38635189
61Cerebral aneurysm (HP:0004944)2.35235303
62Ileus (HP:0002595)2.34916657
63Overgrowth (HP:0001548)2.30263305
64Pheochromocytoma (HP:0002666)2.30002345
65Clumsiness (HP:0002312)2.28731986
66Hyperextensible skin (HP:0000974)2.28122167
67Vascular tortuosity (HP:0004948)2.27684198
68Shallow orbits (HP:0000586)2.27629942
69Cerebellar dysplasia (HP:0007033)2.25016093
70Abnormality of calcium-phosphate metabolism (HP:0100530)2.24545968
71Cerebral hemorrhage (HP:0001342)2.23525310
72Protruding tongue (HP:0010808)2.22481011
73Polyuria (HP:0000103)2.22198109
74Increased connective tissue (HP:0009025)2.21216133
75Tetraparesis (HP:0002273)2.14691987
76Fair hair (HP:0002286)2.14454665
77Congenital hepatic fibrosis (HP:0002612)2.12524224
78Cervical subluxation (HP:0003308)2.11900539
79Concave nail (HP:0001598)2.11151878
80Tubulointerstitial abnormality (HP:0001969)2.10691991
81Neuroendocrine neoplasm (HP:0100634)2.08649739
82Furrowed tongue (HP:0000221)2.08638521
83Bladder diverticulum (HP:0000015)2.08187179
84Venous abnormality (HP:0002624)2.06977121
85Hypoglycemic seizures (HP:0002173)2.06971139
86Metabolic alkalosis (HP:0200114)2.05157066
87Hyperinsulinemic hypoglycemia (HP:0000825)2.04889631
88Dilatation of the ascending aorta (HP:0005111)2.04637264
89Gait imbalance (HP:0002141)2.04253683
90Aneurysm (HP:0002617)2.02571799
91Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02134360
92Gaze-evoked nystagmus (HP:0000640)2.01885258
93Visceral angiomatosis (HP:0100761)2.01259793
94Chronic hepatic failure (HP:0100626)1.99070225
95Abnormal urine output (HP:0012590)1.97410565
96Preaxial foot polydactyly (HP:0001841)1.97240799
97Distal upper limb amyotrophy (HP:0007149)1.97022778
98Upper limb amyotrophy (HP:0009129)1.97022778
99Hand muscle atrophy (HP:0009130)1.96438091
100Mesangial abnormality (HP:0001966)1.96049901
101Abnormality of renal excretion (HP:0011036)1.96042282
102Abnormality of glutamine family amino acid metabolism (HP:0010902)1.95599952
103Scapular winging (HP:0003691)1.95511914
104Palpitations (HP:0001962)1.94568961
105Abnormality of the distal phalanges of the toes (HP:0010182)1.94288954
106Ankle contracture (HP:0006466)1.94131417
107Generalized hypopigmentation of hair (HP:0011358)1.94101379
108Hyperglycemia (HP:0003074)1.93530408
109Prolonged QT interval (HP:0001657)1.92297566
110Hypoplasia of dental enamel (HP:0006297)1.91788469
111Long toe (HP:0010511)1.91438107
112Arterial tortuosity (HP:0005116)1.91286253
113Megalencephaly (HP:0001355)1.90556271
114Tibial bowing (HP:0002982)1.90271105
115Wide anterior fontanel (HP:0000260)1.90165590
116Abnormality of the ischium (HP:0003174)1.89659116
117Femoral bowing (HP:0002980)1.88863822
118Prominent supraorbital ridges (HP:0000336)1.88431605
119Follicular hyperkeratosis (HP:0007502)1.88429683
120Infantile muscular hypotonia (HP:0008947)1.87929233
121Congenital primary aphakia (HP:0007707)1.87901244
122Renal cortical cysts (HP:0000803)1.87641093
123Buphthalmos (HP:0000557)1.86642799
124Aplasia/Hypoplasia of the tibia (HP:0005772)1.86203237
125Dynein arm defect of respiratory motile cilia (HP:0012255)1.84871137
126Absent/shortened dynein arms (HP:0200106)1.84871137
127Biconcave vertebral bodies (HP:0004586)1.84828211
128Short hallux (HP:0010109)1.83745220
129Polycythemia (HP:0001901)1.83292228
130Hypoplastic ischia (HP:0003175)1.83058048
131Absent speech (HP:0001344)1.82499419
132Congenital glaucoma (HP:0001087)1.82373573
133Abnormal albumin level (HP:0012116)1.82123100
134Hypoalbuminemia (HP:0003073)1.82123100
135Attenuation of retinal blood vessels (HP:0007843)1.81875723
136Hemangiomatosis (HP:0007461)1.81225492
137Tachypnea (HP:0002789)1.80525818
138Cavernous hemangioma (HP:0001048)1.80468674
139Blue sclerae (HP:0000592)1.80142051
140Hemiparesis (HP:0001269)1.78989367
141Pterygium (HP:0001059)1.78301311
142Congenital sensorineural hearing impairment (HP:0008527)1.78264773
143Arthropathy (HP:0003040)1.78212437
144Hypokalemia (HP:0002900)1.77790184
145Severe muscular hypotonia (HP:0006829)1.77760569
146Abolished electroretinogram (ERG) (HP:0000550)1.77218528
147Stage 5 chronic kidney disease (HP:0003774)1.76541096
148Hypoventilation (HP:0002791)1.76223248
149Cupped ribs (HP:0000887)1.74921029
150Enlarged epiphyses (HP:0010580)1.74877750
151Increased neuronal autofluorescent lipopigment (HP:0002074)1.74474984
152Abnormal hemoglobin (HP:0011902)1.74402087
153Natal tooth (HP:0000695)1.74048341
154Bone cyst (HP:0012062)1.72814261
155Venous insufficiency (HP:0005293)1.72787619
156Glucose intolerance (HP:0000833)1.72101873
157Hematochezia (HP:0002573)1.72045066
158Broad-based gait (HP:0002136)1.71850350
159Bronchomalacia (HP:0002780)1.70112501
160Abnormality of potassium homeostasis (HP:0011042)1.69614583
161Genital tract atresia (HP:0001827)1.69351893
162Aplasia/Hypoplasia of the hallux (HP:0008362)1.69341712
163Abdominal distention (HP:0003270)1.69195556
164Potter facies (HP:0002009)1.69061449
165Facial shape deformation (HP:0011334)1.69061449
166Abnormality of the axillary hair (HP:0100134)1.69005366
167Abnormality of secondary sexual hair (HP:0009888)1.69005366
168Esophageal varix (HP:0002040)1.68762276
169Hyperactive renin-angiotensin system (HP:0000841)1.68358733
170Ketoacidosis (HP:0001993)1.68241141
171Conjunctival hamartoma (HP:0100780)1.67381137
172Bulbous nose (HP:0000414)1.66013173
173Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.64532579
174Adrenal overactivity (HP:0002717)1.64325272
175Vaginal atresia (HP:0000148)1.64158611
176Hypoplastic labia majora (HP:0000059)1.63688404
177Hyperaldosteronism (HP:0000859)1.63635455
178Febrile seizures (HP:0002373)1.63284447
179Abnormal pancreas size (HP:0012094)1.62623804
180Insulin-resistant diabetes mellitus (HP:0000831)1.62047399
181Widely spaced teeth (HP:0000687)1.61737996
182Sclerocornea (HP:0000647)1.61706971
183Syncope (HP:0001279)1.61253742
184Pendular nystagmus (HP:0012043)1.61194718
185Anterior segment dysgenesis (HP:0007700)1.60736272
186Decreased electroretinogram (ERG) amplitude (HP:0000654)1.60024598
187Central scotoma (HP:0000603)1.59608804
188Exostoses (HP:0100777)1.59600752
189Aplasia/Hypoplasia of the tongue (HP:0010295)1.59421253

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.73387790
2ACVR1B3.35895723
3LMTK22.97843449
4ADRBK22.71936252
5TIE12.62656949
6DDR22.45378802
7FER2.39230533
8CASK2.22489957
9DAPK22.16349391
10PDGFRA2.07837125
11BCR2.07334510
12ERN12.06690426
13MST42.03287839
14LIMK11.97299646
15GRK11.94895893
16MAP3K21.93531620
17PAK31.93409563
18TESK11.93381130
19INSRR1.87319687
20PTK61.86530489
21PINK11.82997452
22EPHA31.75280179
23EPHB21.74822577
24TRIB31.70847914
25MAPKAPK31.70819010
26TGFBR11.65309888
27MET1.64303308
28PIK3CG1.62691577
29PTK21.59145844
30MAPK151.58298702
31STK241.58239624
32MAPK131.55444359
33TTN1.54501993
34RIPK11.52344262
35MYLK1.47320032
36MAP3K141.44491897
37MAP2K21.44308827
38MARK11.39211216
39MAP4K21.38927471
40MAP2K11.37126268
41NTRK11.29984588
42ARAF1.28815478
43EPHB11.27265639
44BMPR1B1.26564952
45ZAK1.25512232
46MST1R1.25305433
47WNK41.25194241
48LATS11.21158057
49AKT31.16118477
50NEK91.15268675
51ROCK11.14827764
52CAMK1D1.07253783
53PIM21.06628520
54STK38L1.04848180
55PRKG21.04729466
56LRRK21.03602828
57MAPKAPK51.03107003
58CDC42BPA1.02920194
59TNIK1.02221280
60TRPM71.00544379
61PNCK0.99710730
62LATS20.98194237
63DYRK1B0.96884568
64PRKCE0.94206823
65BMX0.93460694
66PIK3CA0.93147350
67IRAK10.92541391
68CAMK1G0.92056527
69TGFBR20.90669550
70SGK20.87769387
71TAOK30.86954429
72KSR20.85169876
73PAK20.85071665
74PTK2B0.84651265
75RET0.83832572
76EPHA20.83282991
77TLK10.82429654
78CAMK10.80664613
79PRKCG0.80650089
80MAP3K70.80177691
81MAP3K40.79825056
82NTRK20.79732317
83CAMK2D0.79544111
84ADRBK10.78795221
85PRPF4B0.78605554
86PRKD30.78563437
87ERBB20.77901903
88TBK10.77352901
89OBSCN0.76716943
90STK390.76645009
91PKN10.73460618
92NME10.72875849
93SGK4940.72468718
94SGK2230.72468718
95NUAK10.72416237
96ROCK20.71214025
97DMPK0.68720609
98CAMK2A0.67793824
99ERBB30.67598293
100MOS0.67019463
101WNK10.65780465
102PBK0.64306151
103HIPK20.63765694
104CHUK0.62588873
105MAP3K30.62502175
106DAPK30.61127987
107CAMK40.59311375
108MAP3K130.58957271
109MAP2K60.58196427
110PAK60.57070305
111STK30.55365457
112PRKAA10.54432148
113PRKAA20.53602094
114NEK10.53270787
115STK110.52783580
116MAP3K10.52589970
117MAP2K40.52442617
118CAMKK10.51550724
119PASK0.51106210
120NTRK30.50786417
121BRSK20.49709407
122WNK30.49512925
123FGFR20.49277921
124BMPR20.49169429
125ILK0.49057273
126MKNK20.48873153
127EPHA40.47758661
128NLK0.47503565
129PAK40.47494783
130PRKCZ0.47429684
131SRC0.47408583
132CAMK2G0.47035310
133PDGFRB0.45310253
134RPS6KA60.45188124
135MAPK70.44824572
136PHKG20.44234825
137PHKG10.44234825
138RPS6KA40.44224322
139CAMKK20.43960741
140PRKD10.43568185
141FLT30.42934076
142EEF2K0.41933276
143CSNK1G10.41761258
144DYRK30.40848444
145CAMK2B0.40627639
146CSNK1G20.39907023
147ERBB40.39224288
148PRKACA0.39053460
149JAK10.39028198
150GSK3A0.38933814
151OXSR10.38467846
152ABL20.38122136

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009203.76201895
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.70266524
3Nitrogen metabolism_Homo sapiens_hsa009102.36905065
4Ether lipid metabolism_Homo sapiens_hsa005652.28880849
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15584867
6Phototransduction_Homo sapiens_hsa047442.00524640
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.95365173
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.92077884
9Mineral absorption_Homo sapiens_hsa049781.81707296
10Vibrio cholerae infection_Homo sapiens_hsa051101.76555542
11ECM-receptor interaction_Homo sapiens_hsa045121.75025052
12Dilated cardiomyopathy_Homo sapiens_hsa054141.70398748
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.57763363
14Nicotine addiction_Homo sapiens_hsa050331.54052719
15Arachidonic acid metabolism_Homo sapiens_hsa005901.51293862
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.49483919
17Protein digestion and absorption_Homo sapiens_hsa049741.48783666
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46760721
19Protein export_Homo sapiens_hsa030601.46496343
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42702112
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.42126454
22ABC transporters_Homo sapiens_hsa020101.40707817
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.37238372
24Caffeine metabolism_Homo sapiens_hsa002321.36955569
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.36269070
26Chemical carcinogenesis_Homo sapiens_hsa052041.35775516
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34332991
28Insulin secretion_Homo sapiens_hsa049111.33668346
29Focal adhesion_Homo sapiens_hsa045101.31857903
30Tight junction_Homo sapiens_hsa045301.30685913
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30672487
32Selenocompound metabolism_Homo sapiens_hsa004501.29865904
33Oxidative phosphorylation_Homo sapiens_hsa001901.29004821
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.28618111
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25264392
36Glycerolipid metabolism_Homo sapiens_hsa005611.21509476
37beta-Alanine metabolism_Homo sapiens_hsa004101.17947969
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.17390391
39Morphine addiction_Homo sapiens_hsa050321.14961406
40Parkinsons disease_Homo sapiens_hsa050121.14708145
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.13151243
42Cardiac muscle contraction_Homo sapiens_hsa042601.12343310
43Glutamatergic synapse_Homo sapiens_hsa047241.11973389
44Retinol metabolism_Homo sapiens_hsa008301.11101811
45Alzheimers disease_Homo sapiens_hsa050101.09675390
46Dorso-ventral axis formation_Homo sapiens_hsa043201.08486174
47Thyroid hormone synthesis_Homo sapiens_hsa049181.06021042
48Fat digestion and absorption_Homo sapiens_hsa049751.05949659
49Butanoate metabolism_Homo sapiens_hsa006501.03753142
50Circadian rhythm_Homo sapiens_hsa047101.03666329
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03243780
52Amoebiasis_Homo sapiens_hsa051461.02546840
53Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01384946
54Bladder cancer_Homo sapiens_hsa052190.98698124
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97486701
56Proteoglycans in cancer_Homo sapiens_hsa052050.95637751
57Gap junction_Homo sapiens_hsa045400.95393785
58Renin secretion_Homo sapiens_hsa049240.95370118
59Adherens junction_Homo sapiens_hsa045200.95290521
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95017983
61Pancreatic secretion_Homo sapiens_hsa049720.94288457
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.89827383
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89529361
64Taste transduction_Homo sapiens_hsa047420.89027517
65Gastric acid secretion_Homo sapiens_hsa049710.88563939
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88000601
67Cocaine addiction_Homo sapiens_hsa050300.87784881
68Phenylalanine metabolism_Homo sapiens_hsa003600.87346770
69Galactose metabolism_Homo sapiens_hsa000520.85682852
70Fatty acid degradation_Homo sapiens_hsa000710.84711059
71Peroxisome_Homo sapiens_hsa041460.84423598
72Vitamin digestion and absorption_Homo sapiens_hsa049770.84337049
73Sphingolipid metabolism_Homo sapiens_hsa006000.84252620
74Bile secretion_Homo sapiens_hsa049760.84203884
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84196512
76Lysosome_Homo sapiens_hsa041420.83724863
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83460483
78Olfactory transduction_Homo sapiens_hsa047400.81812539
79Cholinergic synapse_Homo sapiens_hsa047250.79693406
80Type II diabetes mellitus_Homo sapiens_hsa049300.79167973
81Dopaminergic synapse_Homo sapiens_hsa047280.79077072
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78527278
83Arginine biosynthesis_Homo sapiens_hsa002200.77240584
84Fructose and mannose metabolism_Homo sapiens_hsa000510.77213759
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76909139
86Hippo signaling pathway_Homo sapiens_hsa043900.75413303
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75105058
88Calcium signaling pathway_Homo sapiens_hsa040200.75075239
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75033567
90Tryptophan metabolism_Homo sapiens_hsa003800.74606073
91Starch and sucrose metabolism_Homo sapiens_hsa005000.73098999
92TNF signaling pathway_Homo sapiens_hsa046680.70829389
93Fatty acid biosynthesis_Homo sapiens_hsa000610.69801761
94Hedgehog signaling pathway_Homo sapiens_hsa043400.68484046
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.67895070
96cAMP signaling pathway_Homo sapiens_hsa040240.67840366
97Amphetamine addiction_Homo sapiens_hsa050310.67717987
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67400519
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66937164
100GABAergic synapse_Homo sapiens_hsa047270.66697758
101PPAR signaling pathway_Homo sapiens_hsa033200.64185361
102Toxoplasmosis_Homo sapiens_hsa051450.63665850
103Circadian entrainment_Homo sapiens_hsa047130.63243134
104Collecting duct acid secretion_Homo sapiens_hsa049660.62811376
105Rheumatoid arthritis_Homo sapiens_hsa053230.62680378
106Basal cell carcinoma_Homo sapiens_hsa052170.62564342
107Salivary secretion_Homo sapiens_hsa049700.62543432
108Propanoate metabolism_Homo sapiens_hsa006400.61888142
109Phagosome_Homo sapiens_hsa041450.61459580
110GnRH signaling pathway_Homo sapiens_hsa049120.61351405
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61220726
112Ovarian steroidogenesis_Homo sapiens_hsa049130.60788065
113Melanoma_Homo sapiens_hsa052180.59676178
114Small cell lung cancer_Homo sapiens_hsa052220.59607379
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59576771
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58202944
117Estrogen signaling pathway_Homo sapiens_hsa049150.57852302
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57144306
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.56886439
120Axon guidance_Homo sapiens_hsa043600.56225866
121Serotonergic synapse_Homo sapiens_hsa047260.54952368
122TGF-beta signaling pathway_Homo sapiens_hsa043500.53946378
123Melanogenesis_Homo sapiens_hsa049160.52246497
124Huntingtons disease_Homo sapiens_hsa050160.51928699
125Lysine degradation_Homo sapiens_hsa003100.51842533
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.51777543
127Histidine metabolism_Homo sapiens_hsa003400.51355800
128Renin-angiotensin system_Homo sapiens_hsa046140.51336702
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51048736
130Synaptic vesicle cycle_Homo sapiens_hsa047210.50546707
131Type I diabetes mellitus_Homo sapiens_hsa049400.49230126
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48902594
133Linoleic acid metabolism_Homo sapiens_hsa005910.48474409
134Tyrosine metabolism_Homo sapiens_hsa003500.47514606
135Rap1 signaling pathway_Homo sapiens_hsa040150.46514282
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46206244
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45908767
138Complement and coagulation cascades_Homo sapiens_hsa046100.45192407
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44792631
140Prolactin signaling pathway_Homo sapiens_hsa049170.43881696
141Regulation of autophagy_Homo sapiens_hsa041400.43851695
142Vitamin B6 metabolism_Homo sapiens_hsa007500.43189796
143Ras signaling pathway_Homo sapiens_hsa040140.41403124
144Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41230261
145Long-term depression_Homo sapiens_hsa047300.41175630
146Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40393561
147Oxytocin signaling pathway_Homo sapiens_hsa049210.40099009
148Arginine and proline metabolism_Homo sapiens_hsa003300.40018863
149Apoptosis_Homo sapiens_hsa042100.39674435

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