ARPP19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)6.44564932
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.86512538
3presynaptic membrane assembly (GO:0097105)5.84665555
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.68066296
5synaptic vesicle exocytosis (GO:0016079)5.49327656
6neurotransmitter-gated ion channel clustering (GO:0072578)5.47459256
7presynaptic membrane organization (GO:0097090)5.47120393
8protein localization to synapse (GO:0035418)5.45187759
9glutamate secretion (GO:0014047)5.34532396
10vocalization behavior (GO:0071625)5.21959981
11neuron cell-cell adhesion (GO:0007158)5.17201521
12regulation of synaptic vesicle exocytosis (GO:2000300)5.08154730
13regulation of glutamate receptor signaling pathway (GO:1900449)4.96157169
14neuronal action potential propagation (GO:0019227)4.95491372
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.91234680
16regulation of short-term neuronal synaptic plasticity (GO:0048172)4.76661183
17positive regulation of neurotransmitter secretion (GO:0001956)4.75493874
18postsynaptic membrane organization (GO:0001941)4.72917657
19sodium ion export (GO:0071436)4.54898462
20neuron-neuron synaptic transmission (GO:0007270)4.50868495
21behavioral response to cocaine (GO:0048148)4.49281291
22cellular potassium ion homeostasis (GO:0030007)4.45716198
23regulation of synaptic vesicle transport (GO:1902803)4.42829690
24positive regulation of neurotransmitter transport (GO:0051590)4.20904388
25regulation of glutamate secretion (GO:0014048)4.16807868
26synaptic vesicle maturation (GO:0016188)4.16209383
27negative regulation of synaptic transmission, GABAergic (GO:0032229)4.15532266
28regulation of excitatory postsynaptic membrane potential (GO:0060079)4.12228477
29long-term synaptic potentiation (GO:0060291)4.11885428
30synaptic transmission, glutamatergic (GO:0035249)4.09481874
31regulation of long-term neuronal synaptic plasticity (GO:0048169)4.04605872
32auditory behavior (GO:0031223)4.00941182
33positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.99870807
34positive regulation of membrane potential (GO:0045838)3.99323125
35layer formation in cerebral cortex (GO:0021819)3.99292070
36locomotory exploration behavior (GO:0035641)3.98727471
37mechanosensory behavior (GO:0007638)3.98680685
38cerebellar granule cell differentiation (GO:0021707)3.95531348
39regulation of postsynaptic membrane potential (GO:0060078)3.93808813
40response to histamine (GO:0034776)3.93773245
41regulation of synapse structural plasticity (GO:0051823)3.93407640
42synaptic transmission, dopaminergic (GO:0001963)3.91592194
43positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.88699165
44ionotropic glutamate receptor signaling pathway (GO:0035235)3.87400671
45glutamate receptor signaling pathway (GO:0007215)3.85522223
46positive regulation of dendritic spine morphogenesis (GO:0061003)3.84306029
47regulation of synaptic transmission, glutamatergic (GO:0051966)3.83191042
48regulation of voltage-gated calcium channel activity (GO:1901385)3.82517438
49negative regulation of dendrite morphogenesis (GO:0050774)3.81317181
50gamma-aminobutyric acid signaling pathway (GO:0007214)3.78701444
51regulation of neuronal synaptic plasticity (GO:0048168)3.76603558
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.71964555
53neurotransmitter secretion (GO:0007269)3.71576162
54regulation of synaptic plasticity (GO:0048167)3.71463942
55regulation of dendritic spine morphogenesis (GO:0061001)3.69425286
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.67597565
57positive regulation of synapse maturation (GO:0090129)3.66554015
58regulation of neurotransmitter secretion (GO:0046928)3.64458427
59serotonin metabolic process (GO:0042428)3.58874403
60negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.51374920
61cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.50901549
62negative regulation of amino acid transport (GO:0051956)3.45318531
63G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.42434194
64regulation of neurotransmitter transport (GO:0051588)3.41849767
65negative regulation of dendrite development (GO:2000171)3.39501176
66regulation of dendritic spine development (GO:0060998)3.37064364
67cell communication by electrical coupling (GO:0010644)3.36049302
68amino acid import (GO:0043090)3.35309488
69L-amino acid import (GO:0043092)3.34407715
70regulation of protein kinase A signaling (GO:0010738)3.32003713
71striatum development (GO:0021756)3.30865576
72energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.30354763
73ATP hydrolysis coupled proton transport (GO:0015991)3.30354763
74response to amphetamine (GO:0001975)3.28578494
75neuron recognition (GO:0008038)3.27958851
76behavioral defense response (GO:0002209)3.24876056
77behavioral fear response (GO:0001662)3.24876056
78positive regulation of synaptic transmission (GO:0050806)3.22462948
79fear response (GO:0042596)3.22149672
80dendritic spine morphogenesis (GO:0060997)3.20908199
81G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.20351197
82long-term memory (GO:0007616)3.19966338
83female mating behavior (GO:0060180)3.19532692
84regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.16359426
85regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.16359426
86cAMP catabolic process (GO:0006198)3.15926692
87positive regulation of synapse assembly (GO:0051965)3.15644327
88response to auditory stimulus (GO:0010996)3.15081915
89regulation of female receptivity (GO:0045924)3.13935593
90axonal fasciculation (GO:0007413)3.13256979
91regulation of Rac protein signal transduction (GO:0035020)3.12196498
92positive regulation of cardiac muscle cell differentiation (GO:2000727)3.11455111
93membrane depolarization (GO:0051899)3.08925653
94positive regulation of synaptic transmission, GABAergic (GO:0032230)3.08582020
95startle response (GO:0001964)3.08313401
96membrane hyperpolarization (GO:0060081)3.07934410
97exploration behavior (GO:0035640)3.06757645
98nuclear pore complex assembly (GO:0051292)3.06471687
99transferrin transport (GO:0033572)3.06372828
100mitotic sister chromatid cohesion (GO:0007064)3.04564189
101learning (GO:0007612)3.03894886
102transmission of nerve impulse (GO:0019226)3.03783022
103regulation of vesicle fusion (GO:0031338)3.02051421
104synaptic vesicle endocytosis (GO:0048488)3.00413322
105peristalsis (GO:0030432)3.00333395
106long term synaptic depression (GO:0060292)3.00238533
107regulation of synapse maturation (GO:0090128)2.98585508
108cytoskeletal anchoring at plasma membrane (GO:0007016)2.98396112
109adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.96376289
110potassium ion homeostasis (GO:0055075)2.94540597
111regulation of synaptic transmission (GO:0050804)2.93893183
112prepulse inhibition (GO:0060134)2.92162490
113neurotransmitter transport (GO:0006836)2.90621136
114visual learning (GO:0008542)2.90090424
115positive regulation of dendritic spine development (GO:0060999)2.89590197
116apical protein localization (GO:0045176)2.85749771
117neuromuscular process controlling balance (GO:0050885)2.85414587
118cellular sodium ion homeostasis (GO:0006883)2.84782675
119neuronal ion channel clustering (GO:0045161)2.83455275
120cell communication involved in cardiac conduction (GO:0086065)2.83075030
121innervation (GO:0060384)2.79584363
122detection of calcium ion (GO:0005513)2.78597150
123organelle transport along microtubule (GO:0072384)2.73047066
124neurotransmitter uptake (GO:0001504)2.71970449
125potassium ion import (GO:0010107)2.71350102
126nuclear pore organization (GO:0006999)2.70945230
127regulation of neurotransmitter levels (GO:0001505)2.70023332
128regulation of cAMP-dependent protein kinase activity (GO:2000479)2.69261826
129vesicle transport along microtubule (GO:0047496)2.66369195
130vesicle docking (GO:0048278)2.61984358
131regulation of ARF protein signal transduction (GO:0032012)2.61875262
132mating behavior (GO:0007617)2.60265133
133regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.57164273
134cellular protein complex localization (GO:0034629)2.55522829
135dendrite morphogenesis (GO:0048813)2.55435373
136regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.52120621
137central nervous system myelination (GO:0022010)2.50882595
138axon ensheathment in central nervous system (GO:0032291)2.50882595
139activation of protein kinase A activity (GO:0034199)2.50479740
140regulation of NFAT protein import into nucleus (GO:0051532)2.47523382
141regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.47021326
142suckling behavior (GO:0001967)2.44696655
143asymmetric protein localization (GO:0008105)2.44687272
144vesicle docking involved in exocytosis (GO:0006904)2.44562388
145clathrin coat assembly (GO:0048268)2.39345699
146paraxial mesoderm development (GO:0048339)2.38477264

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.21669227
2GBX2_23144817_ChIP-Seq_PC3_Human4.70322619
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.36389020
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.22171131
5TAF15_26573619_Chip-Seq_HEK293_Human3.15509439
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.14751881
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.91205954
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.78247778
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.76961500
10TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.69053870
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66219383
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66219383
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.64139155
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58043299
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.50051925
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.49526487
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49450182
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.46709999
19REST_21632747_ChIP-Seq_MESCs_Mouse2.46062939
20SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.34506944
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29566161
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27034713
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25650199
24CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12964877
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06033427
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.05756472
27ZNF217_24962896_ChIP-Seq_MCF-7_Human2.05170207
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.05006965
29FUS_26573619_Chip-Seq_HEK293_Human2.03883144
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.02259654
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.99732842
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.98478557
33P300_19829295_ChIP-Seq_ESCs_Human1.97060526
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.95668660
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.93996507
36AR_21572438_ChIP-Seq_LNCaP_Human1.88727915
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.88290397
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86028057
39E2F7_22180533_ChIP-Seq_HELA_Human1.85648940
40AR_21909140_ChIP-Seq_LNCAP_Human1.85124862
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.84073449
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80610396
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78933071
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76566397
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74181006
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73921976
47DROSHA_22980978_ChIP-Seq_HELA_Human1.73679365
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.72528713
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71722706
50VDR_22108803_ChIP-Seq_LS180_Human1.71704097
51SMAD4_21799915_ChIP-Seq_A2780_Human1.70773682
52RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.65353891
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.60309352
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59840489
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.57854000
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57033914
57DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.56389712
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.55173854
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52655854
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52572735
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49431136
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47463629
63RNF2_27304074_Chip-Seq_NSC_Mouse1.45084072
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.44773420
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.44076795
66TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.43281993
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42220075
68NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39967825
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39487946
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.38085961
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37749223
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35136731
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34931297
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.32841992
75CTNNB1_20460455_ChIP-Seq_HCT116_Human1.31156506
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.29793365
77ER_23166858_ChIP-Seq_MCF-7_Human1.29648214
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28549344
79CLOCK_20551151_ChIP-Seq_293T_Human1.28150436
80SOX9_26525672_Chip-Seq_HEART_Mouse1.26710983
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.25951626
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24706911
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24674861
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24156466
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.24090899
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23513897
87AR_25329375_ChIP-Seq_VCAP_Human1.23008847
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21197232
89IGF1R_20145208_ChIP-Seq_DFB_Human1.20279057
90JUN_21703547_ChIP-Seq_K562_Human1.19661169
91NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.18777159
92TCF4_23295773_ChIP-Seq_U87_Human1.18018568
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.17737654
94STAT3_23295773_ChIP-Seq_U87_Human1.16301609
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16277904
96EP300_21415370_ChIP-Seq_HL-1_Mouse1.16094081
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15638441
98* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15048739
99* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14499117
100ESR1_20079471_ChIP-ChIP_T-47D_Human1.14097879
101EWS_26573619_Chip-Seq_HEK293_Human1.13045531
102REST_19997604_ChIP-ChIP_NEURONS_Mouse1.12941173
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.11587610
104NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11416848
105ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11321883
106POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.09087045
107WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08525799
108TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07233222
109* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06911435
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06652369
111EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06471914
112TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05363064
113RUNX2_22187159_ChIP-Seq_PCA_Human1.05121736
114CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04600888
115FLI1_27457419_Chip-Seq_LIVER_Mouse1.04407552
116ISL1_27105846_Chip-Seq_CPCs_Mouse1.03754527
117POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.03434203
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.03047850
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.02989240
120TP53_18474530_ChIP-ChIP_U2OS_Human1.02789637
121* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00987503
122P53_22387025_ChIP-Seq_ESCs_Mouse1.00756974
123TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.99540209
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98637066
125SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97796161
126RING1B_27294783_Chip-Seq_NPCs_Mouse0.97719844
127RING1B_27294783_Chip-Seq_ESCs_Mouse0.96998694
128EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96737335
129RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96690944
130PKCTHETA_26484144_Chip-Seq_BREAST_Human0.96590367
131LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96345299
132MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94526441
133AR_19668381_ChIP-Seq_PC3_Human0.93599420
134CMYC_18555785_Chip-Seq_ESCs_Mouse0.93099363
135YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91264099
136AHR_22903824_ChIP-Seq_MCF-7_Human0.90194873
137TP53_16413492_ChIP-PET_HCT116_Human0.89827891
138KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.87834806
139TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87447385
140RXR_22108803_ChIP-Seq_LS180_Human0.87351348
141ZNF274_21170338_ChIP-Seq_K562_Hela0.86753915
142SOX2_18555785_Chip-Seq_ESCs_Mouse0.86403311
143DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85513972
144TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85334742

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.36901380
2MP0004859_abnormal_synaptic_plasticity5.37342003
3MP0002822_catalepsy4.43104573
4MP0003635_abnormal_synaptic_transmissio3.88077864
5MP0009745_abnormal_behavioral_response3.59307187
6MP0001968_abnormal_touch/_nociception3.56891590
7MP0004270_analgesia3.55811576
8MP0002063_abnormal_learning/memory/cond3.30971145
9MP0002064_seizures3.14104967
10MP0009046_muscle_twitch3.11161678
11MP0002736_abnormal_nociception_after2.92991728
12MP0002572_abnormal_emotion/affect_behav2.91025996
13MP0001486_abnormal_startle_reflex2.59794353
14MP0002272_abnormal_nervous_system2.54308636
15MP0002734_abnormal_mechanical_nocicepti2.50832273
16MP0001529_abnormal_vocalization2.50697504
17MP0010234_abnormal_vibrissa_follicle2.26129739
18MP0001440_abnormal_grooming_behavior2.07893525
19MP0003879_abnormal_hair_cell2.07215863
20MP0002067_abnormal_sensory_capabilities2.04899464
21MP0001188_hyperpigmentation1.99900122
22MP0005386_behavior/neurological_phenoty1.97087452
23MP0004924_abnormal_behavior1.97087452
24MP0002735_abnormal_chemical_nociception1.83619947
25MP0005646_abnormal_pituitary_gland1.82459519
26MP0001970_abnormal_pain_threshold1.81671184
27MP0001501_abnormal_sleep_pattern1.79984333
28MP0005423_abnormal_somatic_nervous1.79914325
29MP0008057_abnormal_DNA_replication1.76761415
30MP0001905_abnormal_dopamine_level1.75948187
31MP0002733_abnormal_thermal_nociception1.74574548
32MP0000778_abnormal_nervous_system1.70443877
33MP0003787_abnormal_imprinting1.68862062
34MP0009780_abnormal_chondrocyte_physiolo1.65075105
35MP0002557_abnormal_social/conspecific_i1.63404725
36MP0001984_abnormal_olfaction1.59829483
37MP0008569_lethality_at_weaning1.54675602
38MP0003890_abnormal_embryonic-extraembry1.51913255
39MP0004811_abnormal_neuron_physiology1.47491680
40MP0002877_abnormal_melanocyte_morpholog1.46781557
41MP0010352_gastrointestinal_tract_polyps1.41919538
42MP0002184_abnormal_innervation1.41433090
43MP0005171_absent_coat_pigmentation1.36820531
44MP0002066_abnormal_motor_capabilities/c1.33705089
45MP0009672_abnormal_birth_weight1.30983522
46MP0003941_abnormal_skin_development1.29103430
47MP0000579_abnormal_nail_morphology1.25917953
48MP0006276_abnormal_autonomic_nervous1.24901985
49MP0005409_darkened_coat_color1.23458805
50MP0002882_abnormal_neuron_morphology1.21591708
51MP0000955_abnormal_spinal_cord1.20253951
52MP0003122_maternal_imprinting1.19203274
53MP0008872_abnormal_physiological_respon1.18871923
54MP0010678_abnormal_skin_adnexa1.17005081
55MP0003633_abnormal_nervous_system1.15220936
56MP0002009_preneoplasia1.13831773
57MP0004142_abnormal_muscle_tone1.12817192
58MP0005248_abnormal_Harderian_gland1.12545335
59MP0001485_abnormal_pinna_reflex1.10840274
60MP0008004_abnormal_stomach_pH1.10005186
61MP0005187_abnormal_penis_morphology1.09437735
62MP0004742_abnormal_vestibular_system1.08529359
63MP0003690_abnormal_glial_cell1.07414717
64MP0003634_abnormal_glial_cell1.07360828
65MP0001299_abnormal_eye_distance/1.07122631
66MP0004145_abnormal_muscle_electrophysio1.06305305
67MP0002909_abnormal_adrenal_gland1.04761426
68MP0000569_abnormal_digit_pigmentation1.02290661
69MP0002837_dystrophic_cardiac_calcinosis1.01381181
70MP0003632_abnormal_nervous_system0.97853512
71MP0002876_abnormal_thyroid_physiology0.97451078
72MP0003631_nervous_system_phenotype0.96602766
73MP0002152_abnormal_brain_morphology0.96179666
74MP0001502_abnormal_circadian_rhythm0.94981981
75MP0003329_amyloid_beta_deposits0.94687205
76MP0000751_myopathy0.94531285
77MP0000013_abnormal_adipose_tissue0.93879183
78MP0001963_abnormal_hearing_physiology0.92984395
79MP0008874_decreased_physiological_sensi0.92851628
80MP0004043_abnormal_pH_regulation0.89264222
81MP0000631_abnormal_neuroendocrine_gland0.88874864
82MP0000462_abnormal_digestive_system0.88626989
83MP0001177_atelectasis0.88581301
84MP0009703_decreased_birth_body0.88019357
85MP0010386_abnormal_urinary_bladder0.86310741
86MP0001664_abnormal_digestion0.85608527
87MP0004085_abnormal_heartbeat0.84263480
88MP0000537_abnormal_urethra_morphology0.84167892
89MP0003705_abnormal_hypodermis_morpholog0.84093080
90MP0002081_perinatal_lethality0.81653369
91MP0002069_abnormal_eating/drinking_beha0.78533549
92MP0004185_abnormal_adipocyte_glucose0.75816654
93MP0002653_abnormal_ependyma_morphology0.75704383
94MP0005394_taste/olfaction_phenotype0.75612892
95MP0005499_abnormal_olfactory_system0.75612892
96MP0004957_abnormal_blastocyst_morpholog0.75582235
97MP0008877_abnormal_DNA_methylation0.74729129
98MP0002090_abnormal_vision0.74064974
99MP0004215_abnormal_myocardial_fiber0.72870760
100MP0009379_abnormal_foot_pigmentation0.71899040
101MP0000383_abnormal_hair_follicle0.71812031
102MP0001730_embryonic_growth_arrest0.71591418
103MP0000566_synostosis0.71434251
104MP0004197_abnormal_fetal_growth/weight/0.71358606
105MP0004885_abnormal_endolymph0.71117498
106MP0004484_altered_response_of0.69625334
107MP0002229_neurodegeneration0.69429890
108MP0000534_abnormal_ureter_morphology0.69123551
109MP0002084_abnormal_developmental_patter0.68936635
110MP0000920_abnormal_myelination0.68566017
111MP0002697_abnormal_eye_size0.68262601
112MP0002752_abnormal_somatic_nervous0.65672952
113MP0005551_abnormal_eye_electrophysiolog0.65217349
114MP0001346_abnormal_lacrimal_gland0.63755651
115MP0001943_abnormal_respiration0.63260021
116MP0005380_embryogenesis_phenotype0.62532301
117MP0001672_abnormal_embryogenesis/_devel0.62532301
118MP0000350_abnormal_cell_proliferation0.62441374
119MP0000026_abnormal_inner_ear0.61049935
120MP0003121_genomic_imprinting0.61001035
121MP0005084_abnormal_gallbladder_morpholo0.59800803
122MP0003123_paternal_imprinting0.59302065
123MP0002751_abnormal_autonomic_nervous0.58396189
124MP0005535_abnormal_body_temperature0.57038434
125MP0004036_abnormal_muscle_relaxation0.56037731
126MP0003137_abnormal_impulse_conducting0.54493114
127MP0002082_postnatal_lethality0.52506608
128MP0010770_preweaning_lethality0.52506608
129MP0003861_abnormal_nervous_system0.51731980
130MP0005623_abnormal_meninges_morphology0.50254169
131MP0010769_abnormal_survival0.49843867
132MP0005620_abnormal_muscle_contractility0.48519600
133MP0010768_mortality/aging0.48107906
134MP0002160_abnormal_reproductive_system0.47297541
135MP0000749_muscle_degeneration0.47217896
136MP0004233_abnormal_muscle_weight0.46633396

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.86157957
2Myokymia (HP:0002411)6.45960130
3Epileptic encephalopathy (HP:0200134)6.14608758
4Hyperventilation (HP:0002883)5.56130031
5Focal seizures (HP:0007359)5.39848022
6Atonic seizures (HP:0010819)5.25984190
7Broad-based gait (HP:0002136)4.77879255
8Absence seizures (HP:0002121)4.17568540
9Febrile seizures (HP:0002373)4.03515567
10Dialeptic seizures (HP:0011146)3.99514955
11Poor eye contact (HP:0000817)3.91265869
12Papillary thyroid carcinoma (HP:0002895)3.62051986
13Gaze-evoked nystagmus (HP:0000640)3.45809658
14Generalized tonic-clonic seizures (HP:0002069)3.41142857
15Amblyopia (HP:0000646)3.39645554
16Visual hallucinations (HP:0002367)3.31844177
17Acute necrotizing encephalopathy (HP:0006965)3.29767119
18Sensory axonal neuropathy (HP:0003390)3.18620564
19Abnormal mitochondria in muscle tissue (HP:0008316)3.03268511
20Protruding tongue (HP:0010808)2.98553885
21Impaired social interactions (HP:0000735)2.96538113
22Abnormal social behavior (HP:0012433)2.96538113
23Progressive macrocephaly (HP:0004481)2.93828803
24Progressive cerebellar ataxia (HP:0002073)2.89950338
25Mitochondrial inheritance (HP:0001427)2.82303315
26Impaired vibration sensation in the lower limbs (HP:0002166)2.82145706
27Inability to walk (HP:0002540)2.76967336
28Anxiety (HP:0000739)2.73652716
29Epileptiform EEG discharges (HP:0011182)2.62032103
30Stereotypic behavior (HP:0000733)2.58826747
31Excessive salivation (HP:0003781)2.58529953
32Drooling (HP:0002307)2.58529953
33Focal dystonia (HP:0004373)2.58081292
34Dysmetric saccades (HP:0000641)2.55609097
35Thyroid carcinoma (HP:0002890)2.55214217
36Torticollis (HP:0000473)2.55196922
37Termporal pattern (HP:0011008)2.54958937
38Insidious onset (HP:0003587)2.54958937
39Resting tremor (HP:0002322)2.51951073
40Urinary bladder sphincter dysfunction (HP:0002839)2.50602259
41Dysdiadochokinesis (HP:0002075)2.48458480
42Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.47426267
43Acute encephalopathy (HP:0006846)2.47412725
44Abnormal eating behavior (HP:0100738)2.45106301
45Increased CSF lactate (HP:0002490)2.41709692
46Lower limb muscle weakness (HP:0007340)2.41107273
47Craniofacial dystonia (HP:0012179)2.40026682
48Abnormal hair whorl (HP:0010721)2.39088311
49Asymmetry of the thorax (HP:0001555)2.37775674
50Insomnia (HP:0100785)2.34768436
51Scanning speech (HP:0002168)2.34747723
52Neurofibrillary tangles (HP:0002185)2.32703085
53Abnormality of glycolysis (HP:0004366)2.31642252
54Increased serum pyruvate (HP:0003542)2.31642252
55Truncal ataxia (HP:0002078)2.30743836
56Gait imbalance (HP:0002141)2.30193104
57Dysmetria (HP:0001310)2.29951279
58Supranuclear gaze palsy (HP:0000605)2.29076222
59Hepatocellular necrosis (HP:0001404)2.28110916
60Degeneration of the lateral corticospinal tracts (HP:0002314)2.26123095
61Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.26123095
62Ankle clonus (HP:0011448)2.26010733
63Thickened helices (HP:0000391)2.24904603
64Depression (HP:0000716)2.24858441
65Cerebral inclusion bodies (HP:0100314)2.24016806
66Incomplete penetrance (HP:0003829)2.22265586
67Abnormality of the lower motor neuron (HP:0002366)2.21971757
68Pheochromocytoma (HP:0002666)2.21169353
69Action tremor (HP:0002345)2.20709128
70Intention tremor (HP:0002080)2.20191159
71Abnormality of the labia minora (HP:0012880)2.20151645
72EEG with generalized epileptiform discharges (HP:0011198)2.19947957
73Transitional cell carcinoma of the bladder (HP:0006740)2.18208761
74Absent speech (HP:0001344)2.15276198
75Impaired smooth pursuit (HP:0007772)2.12858124
76Urinary urgency (HP:0000012)2.11857150
77Fetal akinesia sequence (HP:0001989)2.11007043
78Aplasia involving bones of the extremities (HP:0009825)2.10676085
79Aplasia involving bones of the upper limbs (HP:0009823)2.10676085
80Aplasia of the phalanges of the hand (HP:0009802)2.10676085
81Leiomyosarcoma (HP:0100243)2.09527318
82Uterine leiomyosarcoma (HP:0002891)2.09527318
83Neuroendocrine neoplasm (HP:0100634)2.09471062
84Congenital primary aphakia (HP:0007707)2.09161229
85Blue irides (HP:0000635)2.08781757
86Impaired vibratory sensation (HP:0002495)2.08157829
87Medial flaring of the eyebrow (HP:0010747)2.07667735
88Annular pancreas (HP:0001734)2.07296371
89Hyperthyroidism (HP:0000836)2.07110029
90Increased nuchal translucency (HP:0010880)2.06959096
91Papilledema (HP:0001085)2.06406380
92Hepatoblastoma (HP:0002884)2.06047774
93Limb dystonia (HP:0002451)2.02146609
94Cortical dysplasia (HP:0002539)2.00329842
95Hypsarrhythmia (HP:0002521)1.98593639
96Bladder neoplasm (HP:0009725)1.98490734
97Bladder carcinoma (HP:0002862)1.98490734
98Short chin (HP:0000331)1.97477500
99Leukodystrophy (HP:0002415)1.97067657
100Delusions (HP:0000746)1.97013266
101Spastic tetraparesis (HP:0001285)1.95220672
102Ankyloglossia (HP:0010296)1.94337143
103Peripheral hypomyelination (HP:0007182)1.93462294
104Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.93097636
105Nephrogenic diabetes insipidus (HP:0009806)1.92991567
106Split foot (HP:0001839)1.91805992
107Sleep apnea (HP:0010535)1.91034098
108Megalencephaly (HP:0001355)1.90336624
109Vertebral arch anomaly (HP:0008438)1.89891191
110Abnormality of salivation (HP:0100755)1.88627772
111Abnormality of binocular vision (HP:0011514)1.87776638
112Diplopia (HP:0000651)1.87776638
113Tetraplegia (HP:0002445)1.87230025
114X-linked dominant inheritance (HP:0001423)1.87079341
115Heterotopia (HP:0002282)1.87043563
116Hammertoe (HP:0001765)1.86130026
117Abnormality of the corticospinal tract (HP:0002492)1.85740525
118Spastic gait (HP:0002064)1.85362820
119Gastroesophageal reflux (HP:0002020)1.84529798
120Generalized myoclonic seizures (HP:0002123)1.83733199
121Deep philtrum (HP:0002002)1.82954821
122Neoplasm of the thyroid gland (HP:0100031)1.82596354
123Morphological abnormality of the pyramidal tract (HP:0002062)1.82064799
124Fair hair (HP:0002286)1.81928820
125Increased hepatocellular lipid droplets (HP:0006565)1.81762231
126Malignant gastrointestinal tract tumors (HP:0006749)1.81057946
127Gastrointestinal carcinoma (HP:0002672)1.81057946
128Specific learning disability (HP:0001328)1.80389524
129Bradykinesia (HP:0002067)1.79963846
130Optic disc pallor (HP:0000543)1.78439650
131Medulloblastoma (HP:0002885)1.77808406
132Microglossia (HP:0000171)1.76426597
133Lower limb asymmetry (HP:0100559)1.74207447
134Heterochromia iridis (HP:0001100)1.73422101
135Poor suck (HP:0002033)1.71844456
136Status epilepticus (HP:0002133)1.71628043
137Postural instability (HP:0002172)1.70914223
138Progressive inability to walk (HP:0002505)1.70857025
139Curly hair (HP:0002212)1.68324123
140Macroorchidism (HP:0000053)1.67636549
141Respiratory failure (HP:0002878)1.67323343
142Generalized hypopigmentation of hair (HP:0011358)1.67033044
143Neuronal loss in central nervous system (HP:0002529)1.67020690
144Vaginal atresia (HP:0000148)1.66697859
145Lower limb amyotrophy (HP:0007210)1.66679302
146Genital tract atresia (HP:0001827)1.65428873
147Apathy (HP:0000741)1.64223905
148Amyotrophic lateral sclerosis (HP:0007354)1.63865468
149Nephroblastoma (Wilms tumor) (HP:0002667)1.63734982
150Clonus (HP:0002169)1.63468248
151Obstructive sleep apnea (HP:0002870)1.61229890
152Bundle branch block (HP:0011710)1.61213161
153Menstrual irregularities (HP:0000858)1.60616957
154Shoulder girdle muscle weakness (HP:0003547)1.58677774
155Spastic paraplegia (HP:0001258)1.57965474
156Paraplegia (HP:0010550)1.57478453
157Bronchomalacia (HP:0002780)1.57379609

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.85252552
2EPHA45.37832215
3DAPK23.58665133
4CDK193.28541364
5NTRK33.27849234
6CCNB12.96168244
7SCYL22.74624061
8MAP3K122.60575767
9MAP2K72.58606874
10MAP3K42.42584715
11DAPK12.35482365
12MAP3K92.26948795
13PLK22.22812788
14RIPK42.17200520
15OXSR12.12592692
16AKT31.89497264
17PRPF4B1.79486356
18MINK11.63854371
19CAMKK21.60433302
20MARK11.56578105
21KSR11.53706791
22ARAF1.52146653
23BMPR21.46734700
24LATS11.45065312
25MAP2K41.40436976
26PAK61.35456426
27BRAF1.25788770
28KSR21.25403903
29DAPK31.24082763
30CDK51.18965952
31SIK31.18591195
32PDGFRA1.18293802
33TRIM281.17646957
34CAMKK11.17525115
35ERBB31.16498373
36BRD41.13942676
37STK38L1.12682371
38BCR1.11957372
39PTK2B1.06643065
40MAPK131.05324072
41GRK51.03170769
42BRSK11.03011021
43ALK1.02578563
44CDK181.01616647
45SGK2231.00039584
46SGK4941.00039584
47FGFR20.99415994
48PHKG20.98261057
49PHKG10.98261057
50PKN20.96353276
51CAMK2B0.95632717
52NME10.94739656
53CAMK2A0.94666412
54EEF2K0.94146052
55CDK150.93087566
56CDK140.92274868
57TNIK0.90764782
58PRKCG0.90236401
59CAMK1G0.89287859
60SRPK10.89050479
61TTK0.86830488
62UHMK10.83751402
63CDK11A0.82198656
64MAPK100.80175149
65MAP3K100.79831692
66NTRK20.79486152
67RAF10.76556943
68SGK20.76139791
69YES10.71577764
70FGFR10.71030311
71RET0.70947979
72NTRK10.70321253
73STK390.69073229
74CDK120.68713354
75PNCK0.67553970
76MAP3K20.65107673
77RPS6KB10.64049398
78MYLK0.63306220
79PRKD30.62966245
80TLK10.61846736
81FGFR30.60956922
82TSSK60.59437519
83STK30.59298745
84FES0.59243463
85CSNK1A1L0.59158126
86WNK10.59040236
87PIK3CA0.59022112
88CDK60.58213386
89DMPK0.57375781
90WEE10.57373992
91PRKCH0.56727902
92FGR0.56559805
93NEK10.55943703
94SGK10.55850032
95MAPK70.55742651
96CDC70.55731343
97CAMK10.55701103
98PAK30.55229014
99STK110.55004117
100CSNK1G10.52673801
101TAOK10.52648996
102EIF2AK10.50663798
103PRKCE0.49744136
104CSNK1E0.49173830
105EIF2AK30.48735699
106MAP3K130.47975709
107PBK0.47927091
108MKNK10.47921763
109PDPK10.46872010
110RIPK10.45438813
111PLK30.45080169
112ERBB40.44848614
113CAMK2D0.44558730
114ADRBK10.44296620
115NEK60.40748292
116CAMK2G0.40651811
117SIK20.40192751
118MKNK20.39816471
119SGK30.39593075
120MAP2K10.39571527
121CDK30.39490259
122MUSK0.37610137
123ROCK20.37150921
124LATS20.36840633
125PDK10.36837462
126LIMK10.36714423
127CAMK40.34960300
128TYRO30.34090776
129CSNK1G20.33077603
130PINK10.32073785
131MAPKAPK50.31946916
132MAPK120.31740511
133VRK10.29753204
134PRKACA0.28064993
135FRK0.27968944
136DYRK1A0.27839914
137STK160.27277870
138WNK40.25310465
139CSNK1A10.24080609
140RPS6KA30.22687551
141PRKCB0.21946111
142PRKCA0.21935005

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.79905339
2Nicotine addiction_Homo sapiens_hsa050333.64805387
3Olfactory transduction_Homo sapiens_hsa047403.02665083
4Amphetamine addiction_Homo sapiens_hsa050312.95541697
5Collecting duct acid secretion_Homo sapiens_hsa049662.88720455
6Long-term potentiation_Homo sapiens_hsa047202.82979860
7Morphine addiction_Homo sapiens_hsa050322.80281514
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.78007112
9Circadian entrainment_Homo sapiens_hsa047132.72971627
10Oxidative phosphorylation_Homo sapiens_hsa001902.51278967
11Glutamatergic synapse_Homo sapiens_hsa047242.44972963
12GABAergic synapse_Homo sapiens_hsa047272.42745229
13Dopaminergic synapse_Homo sapiens_hsa047282.37723435
14Parkinsons disease_Homo sapiens_hsa050122.10484739
15Salivary secretion_Homo sapiens_hsa049702.08236009
16Renin secretion_Homo sapiens_hsa049242.07759731
17Cocaine addiction_Homo sapiens_hsa050301.85370743
18Vibrio cholerae infection_Homo sapiens_hsa051101.84117078
19Serotonergic synapse_Homo sapiens_hsa047261.81403581
20Cholinergic synapse_Homo sapiens_hsa047251.78613541
21Oxytocin signaling pathway_Homo sapiens_hsa049211.78148290
22Alzheimers disease_Homo sapiens_hsa050101.77799858
23Vitamin B6 metabolism_Homo sapiens_hsa007501.77544677
24Gastric acid secretion_Homo sapiens_hsa049711.73597287
25Long-term depression_Homo sapiens_hsa047301.73591859
26Insulin secretion_Homo sapiens_hsa049111.68773429
27Taste transduction_Homo sapiens_hsa047421.68710589
28Cardiac muscle contraction_Homo sapiens_hsa042601.66072531
29Calcium signaling pathway_Homo sapiens_hsa040201.59744863
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55895670
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53119432
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52007759
33Gap junction_Homo sapiens_hsa045401.42671750
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40543652
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35836329
36Huntingtons disease_Homo sapiens_hsa050161.35703800
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.32356536
38Endometrial cancer_Homo sapiens_hsa052131.31175747
39Phototransduction_Homo sapiens_hsa047441.27245333
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.23797272
41Adherens junction_Homo sapiens_hsa045201.21290689
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21010098
43GnRH signaling pathway_Homo sapiens_hsa049121.20760735
44Hippo signaling pathway_Homo sapiens_hsa043901.17933029
45cAMP signaling pathway_Homo sapiens_hsa040241.17580916
46Thyroid cancer_Homo sapiens_hsa052161.16775294
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16333409
48Axon guidance_Homo sapiens_hsa043601.15359787
49Oocyte meiosis_Homo sapiens_hsa041141.08797817
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02863417
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01827000
52Melanogenesis_Homo sapiens_hsa049161.01789254
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00252625
54Inositol phosphate metabolism_Homo sapiens_hsa005620.99309334
55Colorectal cancer_Homo sapiens_hsa052100.98816107
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.98285557
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98072632
58ErbB signaling pathway_Homo sapiens_hsa040120.92207340
59Glioma_Homo sapiens_hsa052140.89802750
60mRNA surveillance pathway_Homo sapiens_hsa030150.88775861
61mTOR signaling pathway_Homo sapiens_hsa041500.88181270
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.86500935
63Insulin signaling pathway_Homo sapiens_hsa049100.83752433
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83617585
65AMPK signaling pathway_Homo sapiens_hsa041520.82969402
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82183080
67Alcoholism_Homo sapiens_hsa050340.81296736
68Chronic myeloid leukemia_Homo sapiens_hsa052200.79326431
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78836288
70Estrogen signaling pathway_Homo sapiens_hsa049150.78081327
71MicroRNAs in cancer_Homo sapiens_hsa052060.75822764
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73713093
73Rheumatoid arthritis_Homo sapiens_hsa053230.70151948
74Dilated cardiomyopathy_Homo sapiens_hsa054140.68946133
75Cell cycle_Homo sapiens_hsa041100.68581333
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66334433
77Steroid biosynthesis_Homo sapiens_hsa001000.65999242
78MAPK signaling pathway_Homo sapiens_hsa040100.65902807
79Proteoglycans in cancer_Homo sapiens_hsa052050.65832995
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65727015
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63828422
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63408534
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61788908
84Ras signaling pathway_Homo sapiens_hsa040140.59604066
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59115689
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59083377
87Prolactin signaling pathway_Homo sapiens_hsa049170.58683316
88Pancreatic cancer_Homo sapiens_hsa052120.58244122
89Pancreatic secretion_Homo sapiens_hsa049720.57202372
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55950310
91Fatty acid biosynthesis_Homo sapiens_hsa000610.53275662
92Proteasome_Homo sapiens_hsa030500.53171184
93Focal adhesion_Homo sapiens_hsa045100.50325969
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50221534
95Rap1 signaling pathway_Homo sapiens_hsa040150.50194698
96Prostate cancer_Homo sapiens_hsa052150.49472162
97Wnt signaling pathway_Homo sapiens_hsa043100.47595555
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47424000
99Prion diseases_Homo sapiens_hsa050200.46627393
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45866359
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45841064
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42897550
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40600618
104VEGF signaling pathway_Homo sapiens_hsa043700.39864767
105Renal cell carcinoma_Homo sapiens_hsa052110.39807435
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39715938
107Type II diabetes mellitus_Homo sapiens_hsa049300.39137374
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.38340648
109Phagosome_Homo sapiens_hsa041450.35191467
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34183984
111Thyroid hormone synthesis_Homo sapiens_hsa049180.34026278
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32677648
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.32531701
114African trypanosomiasis_Homo sapiens_hsa051430.32449284
115Circadian rhythm_Homo sapiens_hsa047100.30912880
116Melanoma_Homo sapiens_hsa052180.30347501
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29155063
118Tight junction_Homo sapiens_hsa045300.28848041
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27680426
120Choline metabolism in cancer_Homo sapiens_hsa052310.27592156
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.25808306
122Glucagon signaling pathway_Homo sapiens_hsa049220.25443624
123Non-small cell lung cancer_Homo sapiens_hsa052230.23545579
124RNA polymerase_Homo sapiens_hsa030200.21754654
125Type I diabetes mellitus_Homo sapiens_hsa049400.19451730
126Purine metabolism_Homo sapiens_hsa002300.19089708
127Ether lipid metabolism_Homo sapiens_hsa005650.18655315
128Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18378566
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.18346215
130Dorso-ventral axis formation_Homo sapiens_hsa043200.17241381
131Endocytosis_Homo sapiens_hsa041440.15840820
132Pyruvate metabolism_Homo sapiens_hsa006200.15575671
133Chemokine signaling pathway_Homo sapiens_hsa040620.15495640

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