ARR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a non-visual arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of guanylate cyclase activity (GO:0031284)9.83689911
2detection of light stimulus (GO:0009583)9.82731169
3regulation of guanylate cyclase activity (GO:0031282)8.88483885
4retinal rod cell development (GO:0046548)8.70021234
5GMP metabolic process (GO:0046037)8.11135541
6* visual perception (GO:0007601)8.09739266
7* sensory perception of light stimulus (GO:0050953)8.00246210
8cellular response to light stimulus (GO:0071482)7.07477638
9detection of external stimulus (GO:0009581)6.89587872
10vitamin A metabolic process (GO:0006776)6.77623849
11detection of abiotic stimulus (GO:0009582)6.75758875
12glycerophospholipid catabolic process (GO:0046475)6.45542642
13detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)6.40036186
14regulation of cGMP metabolic process (GO:0030823)6.11149717
15positive regulation of T cell cytokine production (GO:0002726)6.03429447
16cellular response to electrical stimulus (GO:0071257)6.01270515
17regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.96300884
18phospholipid scrambling (GO:0017121)5.86026446
19positive regulation of cGMP biosynthetic process (GO:0030828)5.78857907
20retina development in camera-type eye (GO:0060041)5.62121157
21eye photoreceptor cell differentiation (GO:0001754)5.55663639
22photoreceptor cell differentiation (GO:0046530)5.55663639
23regulation of cGMP biosynthetic process (GO:0030826)5.43167113
24positive regulation of cGMP metabolic process (GO:0030825)5.09899392
25negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.86701123
26regulation of retinoic acid receptor signaling pathway (GO:0048385)4.76948018
27positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.70732574
28cellular response to radiation (GO:0071478)4.52997582
29Golgi to endosome transport (GO:0006895)4.50220952
30autophagic vacuole fusion (GO:0000046)4.44567429
31adaptation of signaling pathway (GO:0023058)4.40833521
32regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.19527209
33nonmotile primary cilium assembly (GO:0035058)4.17228000
34branched-chain amino acid catabolic process (GO:0009083)4.13816279
35receptor guanylyl cyclase signaling pathway (GO:0007168)4.02223862
36early endosome to late endosome transport (GO:0045022)3.97441711
37regulation of clathrin-mediated endocytosis (GO:2000369)3.92796386
38regulation of translation in response to stress (GO:0043555)3.89603252
39regulation of voltage-gated calcium channel activity (GO:1901385)3.87365983
40growth hormone receptor signaling pathway (GO:0060396)3.85094007
41* sensory perception (GO:0007600)3.84656942
42head development (GO:0060322)3.84129006
43regulation of short-term neuronal synaptic plasticity (GO:0048172)3.84123110
44response to light stimulus (GO:0009416)3.84060729
45regulation of mitochondrial translation (GO:0070129)3.83505368
46entrainment of circadian clock (GO:0009649)3.80417015
47estrogen biosynthetic process (GO:0006703)3.74045721
48positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.73372779
49positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.69527830
50cell morphogenesis involved in neuron differentiation (GO:0048667)3.67227757
51glycosylceramide metabolic process (GO:0006677)3.66909441
52detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.63954010
53response to histamine (GO:0034776)3.57362711
54regulation of T cell cytokine production (GO:0002724)3.55298946
55mannosylation (GO:0097502)3.53757687
56positive regulation of action potential (GO:0045760)3.53135451
57vesicle fusion (GO:0006906)3.49387486
58retina layer formation (GO:0010842)3.45007643
59positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.43285298
60neuron development (GO:0048666)3.43191992
61detection of chemical stimulus involved in sensory perception (GO:0050907)3.41161463
62membrane hyperpolarization (GO:0060081)3.41103415
63activation of MAPKKK activity (GO:0000185)3.40732495
64protein prenylation (GO:0018342)3.40108576
65prenylation (GO:0097354)3.40108576
66cellular response to growth hormone stimulus (GO:0071378)3.39746367
67triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.39347926
68COPII vesicle coating (GO:0048208)3.36961613
69CDP-diacylglycerol biosynthetic process (GO:0016024)3.35321400
70positive regulation of neurotransmitter transport (GO:0051590)3.35181624
71positive regulation of p38MAPK cascade (GO:1900745)3.31911992
72behavioral response to ethanol (GO:0048149)3.28530143
73protein localization to synapse (GO:0035418)3.28059748
74seminiferous tubule development (GO:0072520)3.24113073
75pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.23676338
76synaptic vesicle docking involved in exocytosis (GO:0016081)3.23126603
77regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.22468499
78regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.22468499
79retinoid metabolic process (GO:0001523)3.20185761
80positive regulation of ERBB signaling pathway (GO:1901186)3.19977038
81response to electrical stimulus (GO:0051602)3.18321538
82organelle membrane fusion (GO:0090174)3.18317298
83establishment of protein localization to Golgi (GO:0072600)3.16842888
84positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.16403081
85chemosensory behavior (GO:0007635)3.15104356
86branched-chain amino acid metabolic process (GO:0009081)3.13955986
87protein targeting to Golgi (GO:0000042)3.13590712
88positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.13049079
89retinol metabolic process (GO:0042572)3.12678243
90short-term memory (GO:0007614)3.10649932
91regulation of phospholipase A2 activity (GO:0032429)3.10052058
92DNA deamination (GO:0045006)3.07584193
93CDP-diacylglycerol metabolic process (GO:0046341)3.06677446
94synaptic vesicle maturation (GO:0016188)3.04996670
95nucleotide salvage (GO:0043173)3.04751052
96negative regulation of Rho protein signal transduction (GO:0035024)3.04509941
97negative regulation of smooth muscle cell differentiation (GO:0051151)3.04106762
98cell wall macromolecule catabolic process (GO:0016998)3.02804805
99positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.02754117
100histone H2A acetylation (GO:0043968)3.01634020
101complement activation, alternative pathway (GO:0006957)3.00980184
102diterpenoid metabolic process (GO:0016101)2.97634217
103purine nucleotide salvage (GO:0032261)2.97536508
104peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.95791655
105protein polyglutamylation (GO:0018095)2.95677076
106inactivation of MAPK activity (GO:0000188)2.94919796
107glycerolipid catabolic process (GO:0046503)2.94595270
108neuronal action potential propagation (GO:0019227)2.92656669
109linoleic acid metabolic process (GO:0043651)2.92577677
110lipopolysaccharide biosynthetic process (GO:0009103)2.91807776
111pyrimidine nucleotide catabolic process (GO:0006244)2.90893528
112phosphatidylethanolamine metabolic process (GO:0046337)2.90353699
113positive regulation of cyclase activity (GO:0031281)2.88283881
114positive regulation of sodium ion transmembrane transport (GO:1902307)2.87646292
115low-density lipoprotein particle remodeling (GO:0034374)2.87633885
116fibroblast migration (GO:0010761)2.86559435
117retrograde transport, vesicle recycling within Golgi (GO:0000301)2.84833200
118axoneme assembly (GO:0035082)2.84676239
119response to gravity (GO:0009629)2.82627756
120UDP-N-acetylglucosamine metabolic process (GO:0006047)2.80835300
121negative regulation of receptor-mediated endocytosis (GO:0048261)2.78459881
122righting reflex (GO:0060013)2.77807059
123acrosome reaction (GO:0007340)2.76828820
124cilium or flagellum-dependent cell motility (GO:0001539)2.75968053
125sialylation (GO:0097503)2.74873789
126regulation of hexokinase activity (GO:1903299)2.74628645
127regulation of glucokinase activity (GO:0033131)2.74628645
128regulation of penile erection (GO:0060405)2.72832883
129terpenoid metabolic process (GO:0006721)2.72233255
130multicellular organism reproduction (GO:0032504)2.71885803
131activated T cell proliferation (GO:0050798)2.67378800
132startle response (GO:0001964)2.66940473
133response to growth hormone (GO:0060416)2.65713949
134positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)2.65668588
135pinocytosis (GO:0006907)2.65588138
136sperm motility (GO:0030317)2.64638266
137positive regulation of lyase activity (GO:0051349)2.63702425
138N-terminal protein amino acid acetylation (GO:0006474)2.62246120
139cell wall macromolecule metabolic process (GO:0044036)2.62181089
140retina homeostasis (GO:0001895)2.61621292
141cellular response to nitric oxide (GO:0071732)2.61463619
142estrogen metabolic process (GO:0008210)2.60717943
143pyrimidine dimer repair (GO:0006290)2.60404884
144response to radiation (GO:0009314)2.60296905
145cellular potassium ion homeostasis (GO:0030007)2.60050876
146negative regulation of cation channel activity (GO:2001258)2.59547051
147behavioral response to cocaine (GO:0048148)2.58732446
148positive regulation of catecholamine secretion (GO:0033605)2.58453318
149positive regulation of natural killer cell differentiation (GO:0032825)2.58438682
150regulation of membrane lipid distribution (GO:0097035)2.57651546
151positive regulation of defense response to virus by host (GO:0002230)2.55034358
152phospholipid translocation (GO:0045332)2.54738763
153lipid translocation (GO:0034204)2.54738763
154interleukin-6-mediated signaling pathway (GO:0070102)2.54517043
155negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.54496859
156negative regulation of calcium ion transmembrane transport (GO:1903170)2.54496859
157synaptic transmission, dopaminergic (GO:0001963)2.51275696
158dopamine receptor signaling pathway (GO:0007212)2.50413509
159negative regulation of transcription regulatory region DNA binding (GO:2000678)2.50110506
160icosanoid secretion (GO:0032309)2.44060465
161arachidonic acid secretion (GO:0050482)2.44060465
162positive regulation of muscle hypertrophy (GO:0014742)2.39032008
163positive regulation of cardiac muscle hypertrophy (GO:0010613)2.39032008
164regulation of synaptic vesicle exocytosis (GO:2000300)2.36962511
165post-embryonic morphogenesis (GO:0009886)2.36484075
166glutamate secretion (GO:0014047)2.36265078
167sodium ion export (GO:0071436)2.34972941
168regulation of rhodopsin mediated signaling pathway (GO:0022400)17.1637888
169rhodopsin mediated signaling pathway (GO:0016056)16.8217028
170retinal cone cell development (GO:0046549)16.7225766
171protein-chromophore linkage (GO:0018298)12.0737734
172photoreceptor cell development (GO:0042461)11.5177586
173eye photoreceptor cell development (GO:0042462)11.1436007
174detection of light stimulus involved in visual perception (GO:0050908)11.0684819
175detection of light stimulus involved in sensory perception (GO:0050962)11.0684819
176phototransduction, visible light (GO:0007603)10.4401893
177phototransduction (GO:0007602)10.4191881
178photoreceptor cell maintenance (GO:0045494)10.1074108
179detection of visible light (GO:0009584)10.0357797

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human6.99792569
2CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse3.74049307
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.53824085
4GBX2_23144817_ChIP-Seq_PC3_Human3.51066879
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.33821337
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.26401390
7ZNF274_21170338_ChIP-Seq_K562_Hela3.26237900
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.13095856
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.12228571
10VDR_24787735_ChIP-Seq_THP-1_Human2.84878877
11VDR_22108803_ChIP-Seq_LS180_Human2.60427132
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.46409759
13DROSHA_22980978_ChIP-Seq_HELA_Human2.38362560
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.11566205
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.07483193
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.01690534
17GATA2_21666600_ChIP-Seq_HMVEC_Human2.01254630
18SMAD_19615063_ChIP-ChIP_OVARY_Human1.99014631
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.93939409
20DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.91600488
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.90639541
22AR_21572438_ChIP-Seq_LNCaP_Human1.90412771
23RARB_27405468_Chip-Seq_BRAIN_Mouse1.89282658
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87288003
25REST_21632747_ChIP-Seq_MESCs_Mouse1.84955958
26P53_22127205_ChIP-Seq_FIBROBLAST_Human1.84744828
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84592223
28SMAD3_21741376_ChIP-Seq_HESCs_Human1.83208551
29BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.82858132
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71918011
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.71275966
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.70178873
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.68083225
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68064419
35SMAD4_21799915_ChIP-Seq_A2780_Human1.57256887
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.53841635
37TP53_18474530_ChIP-ChIP_U2OS_Human1.53673166
38JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52042337
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.51854328
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.51854328
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51557770
42* AR_19668381_ChIP-Seq_PC3_Human1.51207229
43KDM2B_26808549_Chip-Seq_K562_Human1.49902104
44TFEB_21752829_ChIP-Seq_HELA_Human1.48039829
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.48031527
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46607942
47CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46564553
48BCAT_22108803_ChIP-Seq_LS180_Human1.45983051
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44284644
50CJUN_26792858_Chip-Seq_BT549_Human1.44165395
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.43527488
52TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.43328514
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42237512
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41450387
55TCF4_18268006_ChIP-ChIP_LS174T_Human1.39190241
56FUS_26573619_Chip-Seq_HEK293_Human1.38894663
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38497696
58IGF1R_20145208_ChIP-Seq_DFB_Human1.38330539
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.37032673
60IRF8_21731497_ChIP-ChIP_J774_Mouse1.36882878
61EGR1_23403033_ChIP-Seq_LIVER_Mouse1.36484939
62STAT3_23295773_ChIP-Seq_U87_Human1.36020592
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.34858599
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.34795154
65Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34115048
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.33371030
67JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32719227
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31434142
69TBL1_22424771_ChIP-Seq_293T_Human1.30242061
70RING1B_27294783_Chip-Seq_NPCs_Mouse1.29529268
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28575917
72EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28055320
73ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.27707302
74BRD4_25478319_ChIP-Seq_HGPS_Human1.26753351
75ISL1_27105846_Chip-Seq_CPCs_Mouse1.26149145
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24780570
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23266012
78EOMES_21245162_ChIP-Seq_HESCs_Human1.23141577
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21636758
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.21569238
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.20794907
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20714519
83TP53_16413492_ChIP-PET_HCT116_Human1.20653206
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19116819
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18887680
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18869902
87CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18502555
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17984753
89P300_19829295_ChIP-Seq_ESCs_Human1.17983574
90EWS_26573619_Chip-Seq_HEK293_Human1.17468356
91HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17374234
92* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16133410
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15545214
94CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15002059
95TAF2_19829295_ChIP-Seq_ESCs_Human1.14821363
96FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14730830
97NANOG_20526341_ChIP-Seq_ESCs_Human1.14251437
98YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13284331
99NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12597099
100LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12381263
101JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11222609
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11146762
103PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.11094585
104RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10696784
105ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09992281
106STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09287711
107* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08641785
108GATA3_21878914_ChIP-Seq_MCF-7_Human1.07502201
109TCF4_23295773_ChIP-Seq_U87_Human1.07276456
110CTCF_27219007_Chip-Seq_Bcells_Human1.06604708
111EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05248378
112VDR_24763502_ChIP-Seq_THP-1_Human1.05047174
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04164345
114SMAD4_21741376_ChIP-Seq_HESCs_Human1.03935449
115CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03832155
116WT1_19549856_ChIP-ChIP_CCG9911_Human1.03692608
117WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03689683
118RXR_22158963_ChIP-Seq_LIVER_Mouse1.03606231
119RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03090621
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03024534
121PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02936226
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01915556
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01092584
124ER_23166858_ChIP-Seq_MCF-7_Human1.01069588
125CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00981375
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00717205
127LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00570605
128WDR5_24793694_ChIP-Seq_LNCAP_Human1.00256754
129FOXA2_19822575_ChIP-Seq_HepG2_Human0.99490579
130GF1_26923725_Chip-Seq_HPCs_Mouse0.99298412
131NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99070775
132CREB1_26743006_Chip-Seq_LNCaP_Human0.98991183
133FLI1_21867929_ChIP-Seq_TH2_Mouse0.98756889
134SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97961962
135RING1B_27294783_Chip-Seq_ESCs_Mouse0.97932880
136OCT4_20526341_ChIP-Seq_ESCs_Human0.97162178
137CBP_21632823_ChIP-Seq_H3396_Human0.96811082
138IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95778235
139SOX2_21211035_ChIP-Seq_LN229_Gbm0.94816953
140RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94691042
141NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94386407
142GATA3_26560356_Chip-Seq_TH2_Human0.94306942
143DPY_21335234_ChIP-Seq_ESCs_Mouse0.94232825
144TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94173153
145TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94164032
146TBX3_20139965_ChIP-Seq_MESCs_Mouse0.93924927
147SALL4_22934838_ChIP-ChIP_CD34+_Human0.93793564
148SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93692703
149THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93478784
150TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93459634
151TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93419004
152OCT1_27270436_Chip-Seq_PROSTATE_Human0.92992406
153ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92819156
154PIAS1_25552417_ChIP-Seq_VCAP_Human0.92585782
155SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92161909
156TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90713313
157TP53_22573176_ChIP-Seq_HFKS_Human0.90657067
158KDM2B_26808549_Chip-Seq_JURKAT_Human0.89923911
159SMC4_20622854_ChIP-Seq_HELA_Human0.89760488
160PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89447083
161NANOG_18555785_Chip-Seq_ESCs_Mouse0.88564026
162SMAD3_21741376_ChIP-Seq_ESCs_Human0.88228502
163PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87553610
164ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87432987
165MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86628180
166STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.86401028
167PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85035457
168TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84469109
169KLF5_20875108_ChIP-Seq_MESCs_Mouse0.84422591
170ELK4_26923725_Chip-Seq_MESODERM_Mouse0.84287368
171GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84245704
172MYB_21317192_ChIP-Seq_ERMYB_Mouse0.84104332
173SRF_21415370_ChIP-Seq_HL-1_Mouse0.84054512
174VDR_23849224_ChIP-Seq_CD4+_Human0.84028146
175RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83790665
176HNF4A_19822575_ChIP-Seq_HepG2_Human0.83639640
177SPI1_23127762_ChIP-Seq_K562_Human0.81099344
178SMAD3_21741376_ChIP-Seq_EPCs_Human0.80818784
179MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.80319546
180SCL_19346495_ChIP-Seq_HPC-7_Human0.80217899
181RXRA_24833708_ChIP-Seq_LIVER_Mouse0.79869095

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog9.57239761
2MP0005253_abnormal_eye_physiology6.76775980
3MP0006072_abnormal_retinal_apoptosis6.66148148
4MP0002090_abnormal_vision3.77140192
5MP0005195_abnormal_posterior_eye3.76049008
6MP0003950_abnormal_plasma_membrane3.53515931
7MP0001324_abnormal_eye_pigmentation3.32655331
8MP0005391_vision/eye_phenotype3.23871965
9MP0005423_abnormal_somatic_nervous2.79421573
10MP0002229_neurodegeneration2.67479557
11MP0003122_maternal_imprinting2.36521856
12MP0000372_irregular_coat_pigmentation2.24758488
13MP0002638_abnormal_pupillary_reflex2.21447756
14MP0003011_delayed_dark_adaptation10.6007294
15MP0002752_abnormal_somatic_nervous1.90815253
16MP0001764_abnormal_homeostasis1.86564183
17MP0003300_gastrointestinal_ulcer1.83476873
18MP0002139_abnormal_hepatobiliary_system1.75798689
19MP0001986_abnormal_taste_sensitivity1.71247344
20MP0003878_abnormal_ear_physiology1.68346067
21MP0005377_hearing/vestibular/ear_phenot1.68346067
22MP0005464_abnormal_platelet_physiology1.67555130
23MP0005220_abnormal_exocrine_pancreas1.52120982
24MP0002102_abnormal_ear_morphology1.51042717
25MP0005397_hematopoietic_system_phenotyp1.48321790
26MP0001545_abnormal_hematopoietic_system1.48321790
27MP0002882_abnormal_neuron_morphology1.44095799
28MP0004019_abnormal_vitamin_homeostasis1.43804221
29MP0002653_abnormal_ependyma_morphology1.42784814
30MP0005410_abnormal_fertilization1.37809819
31MP0004233_abnormal_muscle_weight1.33826955
32MP0002396_abnormal_hematopoietic_system1.33279074
33MP0000003_abnormal_adipose_tissue1.31973928
34MP0001984_abnormal_olfaction1.28921320
35MP0004270_analgesia1.27949506
36MP0001486_abnormal_startle_reflex1.22938196
37MP0004264_abnormal_extraembryonic_tissu1.21951167
38MP0003121_genomic_imprinting1.14948887
39MP0003880_abnormal_central_pattern1.12163913
40MP0003566_abnormal_cell_adhesion1.10253698
41MP0001502_abnormal_circadian_rhythm1.09233418
42MP0003787_abnormal_imprinting1.03988870
43MP0004885_abnormal_endolymph0.94891502
44MP0004859_abnormal_synaptic_plasticity0.93587157
45MP0001661_extended_life_span0.93140404
46MP0005310_abnormal_salivary_gland0.92430624
47MP0005375_adipose_tissue_phenotype0.92106022
48MP0008007_abnormal_cellular_replicative0.90509191
49MP0001485_abnormal_pinna_reflex0.89469951
50MP0008004_abnormal_stomach_pH0.86286266
51MP0008877_abnormal_DNA_methylation0.84863271
52MP0008775_abnormal_heart_ventricle0.84814917
53MP0004808_abnormal_hematopoietic_stem0.84625498
54MP0006292_abnormal_olfactory_placode0.81811454
55MP0000358_abnormal_cell_content/0.81778389
56MP0000858_altered_metastatic_potential0.81645450
57MP0005197_abnormal_uvea_morphology0.81630551
58MP0002272_abnormal_nervous_system0.81598184
59MP0000013_abnormal_adipose_tissue0.80783931
60MP0003635_abnormal_synaptic_transmissio0.80370780
61MP0002168_other_aberrant_phenotype0.78744307
62MP0002064_seizures0.76813736
63MP0002332_abnormal_exercise_endurance0.76790984
64MP0002734_abnormal_mechanical_nocicepti0.72636891
65MP0003195_calcinosis0.71222277
66MP0001968_abnormal_touch/_nociception0.70302802
67MP0003634_abnormal_glial_cell0.69946990
68MP0005499_abnormal_olfactory_system0.68630176
69MP0005394_taste/olfaction_phenotype0.68630176
70MP0002971_abnormal_brown_adipose0.67722592
71MP0000465_gastrointestinal_hemorrhage0.66565741
72MP0002127_abnormal_cardiovascular_syste0.65624142
73MP0009046_muscle_twitch0.64356079
74MP0008058_abnormal_DNA_repair0.64260849
75MP0004272_abnormal_basement_membrane0.63351338
76MP0002063_abnormal_learning/memory/cond0.62871640
77MP0009384_cardiac_valve_regurgitation0.61792743
78MP0005332_abnormal_amino_acid0.61337270
79MP0005084_abnormal_gallbladder_morpholo0.61225156
80MP0000343_altered_response_to0.60882556
81MP0002572_abnormal_emotion/affect_behav0.60789141
82MP0009763_increased_sensitivity_to0.60079705
83MP0003567_abnormal_fetal_cardiomyocyte0.60056937
84MP0004924_abnormal_behavior0.60054336
85MP0005386_behavior/neurological_phenoty0.60054336
86MP0002909_abnormal_adrenal_gland0.59851904
87MP0005360_urolithiasis0.59631838
88MP0010329_abnormal_lipoprotein_level0.59354748
89MP0005666_abnormal_adipose_tissue0.59254381
90MP0002933_joint_inflammation0.58760146
91MP0010368_abnormal_lymphatic_system0.57997080
92MP0005187_abnormal_penis_morphology0.57487825
93MP0005058_abnormal_lysosome_morphology0.55724416
94MP0000516_abnormal_urinary_system0.55355798
95MP0005367_renal/urinary_system_phenotyp0.55355798
96MP0004185_abnormal_adipocyte_glucose0.55139297
97MP0009745_abnormal_behavioral_response0.54450917
98MP0001270_distended_abdomen0.53546440
99MP0001286_abnormal_eye_development0.52583324
100MP0002067_abnormal_sensory_capabilities0.52446039
101MP0004215_abnormal_myocardial_fiber0.52054619
102MP0010386_abnormal_urinary_bladder0.51025459
103MP0003646_muscle_fatigue0.50086968
104MP0001963_abnormal_hearing_physiology0.49867111
105MP0001835_abnormal_antigen_presentation0.49569325
106MP0002249_abnormal_larynx_morphology0.48649709
107MP0001666_abnormal_nutrient_absorption0.47409701
108MP0003091_abnormal_cell_migration0.47124613
109MP0008789_abnormal_olfactory_epithelium0.45031903
110MP0005174_abnormal_tail_pigmentation0.43817872
111MP0005075_abnormal_melanosome_morpholog0.42838935
112MP0008438_abnormal_cutaneous_collagen0.42715469
113MP0006035_abnormal_mitochondrial_morpho0.42075325
114MP0000015_abnormal_ear_pigmentation0.41877789
115MP0001501_abnormal_sleep_pattern0.41544735
116MP0005384_cellular_phenotype0.41485726
117MP0008569_lethality_at_weaning0.40163364
118MP0001929_abnormal_gametogenesis0.40113518
119MP0002269_muscular_atrophy0.39464141
120MP0005376_homeostasis/metabolism_phenot0.39166893
121MP0005535_abnormal_body_temperature0.38896205
122MP0005620_abnormal_muscle_contractility0.38846354
123MP0003724_increased_susceptibility_to0.38779748
124MP0003868_abnormal_feces_composition0.38741104
125MP0004085_abnormal_heartbeat0.38616100
126MP0005275_abnormal_skin_tensile0.38569070
127MP0005266_abnormal_metabolism0.38423915
128MP0004130_abnormal_muscle_cell0.37716620
129MP0004742_abnormal_vestibular_system0.37034673
130MP0000631_abnormal_neuroendocrine_gland0.31689161
131MP0004036_abnormal_muscle_relaxation0.31431932
132MP0009780_abnormal_chondrocyte_physiolo0.30152840
133MP0003890_abnormal_embryonic-extraembry0.29933197
134MP0001879_abnormal_lymphatic_vessel0.29630886
135MP0002822_catalepsy0.29501325
136MP0002066_abnormal_motor_capabilities/c0.29270027
137MP0002972_abnormal_cardiac_muscle0.28968671
138MP0005076_abnormal_cell_differentiation0.28500816
139MP0003172_abnormal_lysosome_physiology0.28357607
140MP0005646_abnormal_pituitary_gland0.27942637
141MP0004145_abnormal_muscle_electrophysio0.27576687
142MP0002152_abnormal_brain_morphology0.26624345
143MP0003045_fibrosis0.26573471
144MP0004043_abnormal_pH_regulation0.26484232
145MP0004811_abnormal_neuron_physiology0.25990123
146MP0001905_abnormal_dopamine_level0.25882807
147MP0000749_muscle_degeneration0.25473306
148MP0002184_abnormal_innervation0.25202893
149MP0005248_abnormal_Harderian_gland0.25023261
150MP0003252_abnormal_bile_duct0.24415884
151MP0005330_cardiomyopathy0.23223785
152MP0001915_intracranial_hemorrhage0.22972804
153MP0004782_abnormal_surfactant_physiolog0.22332514
154MP0005595_abnormal_vascular_smooth0.21402640
155MP0000778_abnormal_nervous_system0.21294307
156MP0002928_abnormal_bile_duct0.21114032
157MP0003943_abnormal_hepatobiliary_system0.20734640
158MP0005365_abnormal_bile_salt0.18933418
159MP0008875_abnormal_xenobiotic_pharmacok0.17963138
160MP0001177_atelectasis0.17489194
161MP0001970_abnormal_pain_threshold0.17046868
162MP0003075_altered_response_to0.16814086
163MP0004084_abnormal_cardiac_muscle0.16736887
164MP0003633_abnormal_nervous_system0.16696532
165MP0000759_abnormal_skeletal_muscle0.16455996
166MP0008872_abnormal_physiological_respon0.16409258
167MP0002557_abnormal_social/conspecific_i0.16399226

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)9.96777080
2Abnormality of macular pigmentation (HP:0008002)9.21262838
3Abnormal rod and cone electroretinograms (HP:0008323)9.18627725
4Pigmentary retinal degeneration (HP:0001146)8.52022601
5Central scotoma (HP:0000603)8.44003931
6Pendular nystagmus (HP:0012043)7.60475790
7Scotoma (HP:0000575)7.49780797
8Chorioretinal atrophy (HP:0000533)7.23761258
9Attenuation of retinal blood vessels (HP:0007843)7.01851691
10Decreased central vision (HP:0007663)6.81846045
11Abolished electroretinogram (ERG) (HP:0000550)6.46422044
12Photophobia (HP:0000613)5.70340081
13Vitreoretinal degeneration (HP:0000655)5.60697804
14Macular degeneration (HP:0000608)5.27710429
15Severe visual impairment (HP:0001141)5.25267799
16Type II diabetes mellitus (HP:0005978)5.15899030
17Posterior subcapsular cataract (HP:0007787)4.80666117
18Choroideremia (HP:0001139)4.61110127
19Hemorrhage of the eye (HP:0011885)4.58886367
20Thrombocytosis (HP:0001894)4.44846802
21Cone-rod dystrophy (HP:0000548)4.35049845
22Increased corneal curvature (HP:0100692)4.33037797
23Keratoconus (HP:0000563)4.33037797
24Decreased muscle mass (HP:0003199)4.21567417
25Constricted visual fields (HP:0001133)4.13507116
26Retinitis pigmentosa (HP:0000510)3.98595811
27Chronic hepatic failure (HP:0100626)3.63362786
28Decreased electroretinogram (ERG) amplitude (HP:0000654)3.46069028
29Agammaglobulinemia (HP:0004432)3.41170143
30Abnormality of the anterior chamber (HP:0000593)3.32250317
31Bile duct proliferation (HP:0001408)3.31025704
32Abnormal biliary tract physiology (HP:0012439)3.31025704
33Tubulointerstitial nephritis (HP:0001970)3.24436964
34Buphthalmos (HP:0000557)3.19487753
35Oligomenorrhea (HP:0000876)3.17653862
36Myocardial infarction (HP:0001658)3.10606219
37Retinal atrophy (HP:0001105)3.07136515
38Progressive visual loss (HP:0000529)3.00233223
39Abnormal hair whorl (HP:0010721)2.97042180
40Failure to thrive in infancy (HP:0001531)2.94110323
41Subcapsular cataract (HP:0000523)2.93525325
42Congenital sensorineural hearing impairment (HP:0008527)2.82499329
43Abnormal tarsal ossification (HP:0008369)2.81714452
44Polyphagia (HP:0002591)2.75191270
45Abnormality of the peritoneum (HP:0002585)2.72484892
46Glucose intolerance (HP:0000833)2.67037568
47Albinism (HP:0001022)2.64010219
48Atonic seizures (HP:0010819)2.58821857
49Optic disc pallor (HP:0000543)2.57399801
50Acute hepatic failure (HP:0006554)2.52315721
51Complement deficiency (HP:0004431)2.46976042
52Abnormality of the pupil (HP:0000615)2.46924997
53Hypobetalipoproteinemia (HP:0003563)2.41775274
54Tubulointerstitial abnormality (HP:0001969)2.40685950
55Wide nasal bridge (HP:0000431)2.30872317
56Abnormal pancreas size (HP:0012094)2.30549433
57Generalized hypopigmentation (HP:0007513)2.28169576
58Hip dysplasia (HP:0001385)2.22156136
59Growth hormone excess (HP:0000845)2.18763464
60Hemiparesis (HP:0001269)2.18134923
61Abnormality of the labia minora (HP:0012880)2.16951985
62Hyperlipoproteinemia (HP:0010980)2.15278622
63Muscle fiber atrophy (HP:0100295)2.11904239
64Hypoalbuminemia (HP:0003073)2.10974145
65Abnormal albumin level (HP:0012116)2.10974145
66Prominent supraorbital ridges (HP:0000336)2.10940138
67Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.09777782
68Neoplasm of the adrenal cortex (HP:0100641)2.07470299
69Type 2 muscle fiber atrophy (HP:0003554)2.05515745
70Peritonitis (HP:0002586)2.03724587
71Prolonged bleeding time (HP:0003010)2.03511078
72Lymphangioma (HP:0100764)2.03087979
73Cellulitis (HP:0100658)2.02568065
74Congenital stationary night blindness (HP:0007642)14.8935810
75Dyschromatopsia (HP:0007641)12.4568560
76Bony spicule pigmentary retinopathy (HP:0007737)10.8001238
77Recurrent corneal erosions (HP:0000495)1.99802489
78Autoamputation (HP:0001218)1.99349478
793-Methylglutaconic aciduria (HP:0003535)1.98085559
80Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.95923710
81Congenital glaucoma (HP:0001087)1.95882442
82Gait imbalance (HP:0002141)1.95833847
83Abnormality of the alveolar ridges (HP:0006477)1.95420141
84Abnormal foot bone ossification (HP:0010675)1.93399490
85Congenital primary aphakia (HP:0007707)1.93208271
86Abnormal glucose tolerance (HP:0001952)1.92550785
87Horizontal nystagmus (HP:0000666)1.91119141
88Elevated erythrocyte sedimentation rate (HP:0003565)1.90850972
89Menstrual irregularities (HP:0000858)1.90012555
90Hypolipoproteinemia (HP:0010981)1.89975980
91Hyperglycinuria (HP:0003108)1.86265608
92Hypoplasia of the iris (HP:0007676)1.86116467
93Impaired pain sensation (HP:0007328)1.81506086
94Abnormality of pain sensation (HP:0010832)1.81506086
95Severe Myopia (HP:0011003)1.78825480
96Secondary amenorrhea (HP:0000869)1.78521382
97Hepatosplenomegaly (HP:0001433)1.76671199
98Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76662724
99Fatigue (HP:0012378)1.75307392
100Retinal dysplasia (HP:0007973)1.72696495
101Abnormality of small intestinal villus morphology (HP:0011472)1.72481564
102Villous atrophy (HP:0011473)1.72481564
103Myositis (HP:0100614)1.71995473
104Acanthocytosis (HP:0001927)1.69600546
105Intrahepatic cholestasis (HP:0001406)1.69331490
106Nephrogenic diabetes insipidus (HP:0009806)1.67210298
107Osteomyelitis (HP:0002754)1.65645819
108Conjugated hyperbilirubinemia (HP:0002908)1.65338522
109Nausea (HP:0002018)1.65305469
110Metaphyseal dysplasia (HP:0100255)1.64009918
111Enlarged epiphyses (HP:0010580)1.63896158
112Iris hypopigmentation (HP:0007730)1.62779999
113Calf muscle hypertrophy (HP:0008981)1.62433863
114Polar cataract (HP:0010696)1.61067925
115Medial flaring of the eyebrow (HP:0010747)1.60786285
116Epileptic encephalopathy (HP:0200134)1.57609704
117Poor coordination (HP:0002370)1.50619648
118Dysdiadochokinesis (HP:0002075)1.45237372
119Optic atrophy (HP:0000648)1.45126495
120Interstitial pulmonary disease (HP:0006530)1.38407612
121Febrile seizures (HP:0002373)1.37447307
122Vaginal atresia (HP:0000148)1.33474855
123Genital tract atresia (HP:0001827)1.28138843
124Retinal detachment (HP:0000541)1.21198667
125Truncal ataxia (HP:0002078)1.19167253
126Progressive cerebellar ataxia (HP:0002073)1.16300151
127Aplasia/Hypoplasia of the lens (HP:0008063)1.15619248
128Prolonged QT interval (HP:0001657)1.14976179
129Visual hallucinations (HP:0002367)1.12491683
130Genetic anticipation (HP:0003743)1.12091803
131True hermaphroditism (HP:0010459)1.06541323
132Pancreatic fibrosis (HP:0100732)1.05547885
133Macroorchidism (HP:0000053)0.98812485
134Chorioretinal coloboma (HP:0000567)0.96906668
135Astigmatism (HP:0000483)0.96177979
136Broad-based gait (HP:0002136)0.92471627
137Abnormality of the fovea (HP:0000493)0.92396152
138Left ventricular hypertrophy (HP:0001712)0.91420137
139Hyperventilation (HP:0002883)0.89200358
140Aplasia/Hypoplasia of the fovea (HP:0008060)0.88980632
141Hypoplasia of the fovea (HP:0007750)0.88980632
142Abnormal EKG (HP:0003115)0.87348809
143Cystic liver disease (HP:0006706)0.85498317
144Dysmetric saccades (HP:0000641)0.82730343
145Syncope (HP:0001279)0.81774170
146Pancreatic cysts (HP:0001737)0.81299423
147Recurrent sinusitis (HP:0011108)0.81115721
148Aplasia/Hypoplasia of the tongue (HP:0010295)0.80959714
149Hypermetropia (HP:0000540)0.79849876
150Specific learning disability (HP:0001328)0.79278718
151Broad foot (HP:0001769)0.79162378
152Gaze-evoked nystagmus (HP:0000640)0.77794643
153Corneal dystrophy (HP:0001131)0.76450300
154Aqueductal stenosis (HP:0002410)0.74348845
155Abnormality of the fingertips (HP:0001211)0.74228424
156Absence seizures (HP:0002121)0.73533984
157Asthma (HP:0002099)0.72615048
158Abnormality of midbrain morphology (HP:0002418)0.70854097
159Molar tooth sign on MRI (HP:0002419)0.70854097
160Furrowed tongue (HP:0000221)0.69296296
161Aplasia/Hypoplasia of the macula (HP:0008059)0.68940965
162Generalized myoclonic seizures (HP:0002123)0.68831628
163Depression (HP:0000716)0.67872750
164Decreased testicular size (HP:0008734)0.67266900
165Sclerocornea (HP:0000647)0.66585238
166Scanning speech (HP:0002168)0.66165412
167Urinary bladder sphincter dysfunction (HP:0002839)0.66163602
168Abnormality of ocular smooth pursuit (HP:0000617)0.65736582
169Hypoventilation (HP:0002791)0.64441466
170Lymphopenia (HP:0001888)0.63640163
171Intention tremor (HP:0002080)0.63270582
172Aplasia/Hypoplasia affecting the retina (HP:0008061)0.63244648
173Impaired smooth pursuit (HP:0007772)0.62624754
174Cerebellar dysplasia (HP:0007033)0.62505737
175Exercise-induced muscle cramps (HP:0003710)0.61794922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.91680361
2PBK4.87507584
3NUAK14.04908013
4PIK3CA3.05275239
5EPHA32.83029432
6ERBB42.75910886
7PINK12.66520523
8ERN12.43172473
9EPHB12.32788489
10GRK111.4022046
11CAMK1G1.99732244
12ARAF1.95821017
13MAP3K121.88225491
14CDK121.86406114
15MAP3K41.80319252
16TAF11.79712179
17EIF2AK31.79554747
18FGFR41.76365735
19STK391.76068843
20SIK21.75819443
21PIM21.74879946
22PTK2B1.74658685
23PIK3CG1.65135600
24MARK31.61346575
25CAMK1D1.59975726
26ADRBK11.58389632
27TEC1.58375878
28MARK11.55071389
29STK381.54934933
30PAK61.54198324
31MAPK111.52343569
32HIPK21.50484461
33RAF11.49380422
34BRD41.44993269
35PNCK1.44539221
36AKT31.44029024
37RET1.43542001
38NLK1.41548252
39INSRR1.38187216
40MAPK121.38114344
41TGFBR21.37287045
42IRAK21.34799289
43MAPK71.34294750
44ZAK1.33144412
45ADRBK21.33006170
46PLK41.30531342
47TBK11.28026649
48MYLK1.22815903
49STK161.20458099
50MAP3K51.17034986
51SGK21.14209497
52TYK21.14078508
53PRKCQ1.12022835
54PRKCZ1.09470711
55VRK21.08721077
56SGK4941.07871420
57SGK2231.07871420
58PRKCH1.07838242
59CSNK1D1.05029846
60CAMKK11.04314717
61PRKD31.02727775
62SGK30.99683824
63MST1R0.94329713
64FES0.93405801
65IRAK10.93392049
66RPS6KA40.92249347
67FGFR30.90981369
68ILK0.87916264
69ZAP700.87729698
70LATS10.86437884
71PLK20.86124831
72WNK10.85937337
73PRKCB0.83676091
74CSF1R0.83199266
75IKBKB0.81351820
76ERBB20.80817832
77ICK0.80472998
78MAP3K100.80353402
79WNK40.79917333
80TAOK30.79433434
81HCK0.78140382
82MAP2K70.77988324
83CAMK2D0.77278945
84FLT30.75920618
85NTRK30.73872638
86PRKCE0.73785309
87SYK0.72346541
88FRK0.70787942
89PHKG10.68482748
90PHKG20.68482748
91NEK10.68136042
92PRKAA10.67473946
93MINK10.67187987
94CDK50.66906096
95DYRK1A0.66164634
96PDK10.65578613
97MAP2K40.64402954
98CAMK10.62993001
99RPS6KA30.62770154
100GRK50.62466940
101CDK30.58560774
102PRKAA20.57987426
103PRKACG0.57758626
104PRKD10.57723709
105IKBKE0.56958946
106TTK0.56909226
107OBSCN0.56089650
108MAP3K10.55778157
109PDK20.53456383
110MOS0.53040705
111SGK10.51811741
112KIT0.51621749
113MAP3K70.51184259
114MAP3K90.50722058
115MAP3K60.50175704
116PDPK10.47839517
117GSK3B0.45906170
118PRKCI0.45625487
119ERBB30.45382919
120PLK30.44373073
121MAPK100.44327629
122PRKDC0.43274943
123DAPK20.43183662
124MARK20.42269427
125EPHA40.42257918
126CAMK40.41125895
127PRPF4B0.41094335
128TRIM280.39972688
129TGFBR10.39491468
130MAPK140.39438952
131AKT20.39353778
132STK110.39222133
133GRK60.39204017
134PKN20.38988076
135PKN10.38973240
136OXSR10.38383960
137CDK90.38155652
138BLK0.38112003
139MAP3K110.37921103
140MET0.37758132
141ALK0.37567703
142CHEK20.37416420
143CAMK2A0.37359230
144SIK10.36102622
145PRKCA0.35154707
146MAPK90.34855148
147PRKCG0.34754303
148RPS6KB10.34692449
149TNIK0.34221818
150CDC42BPA0.34173803
151PRKACA0.33777869
152IRAK30.33731869
153PRKD20.32531778
154ABL10.31685070
155DYRK1B0.31558431
156MAP2K30.30569424
157TNK20.30230924
158NEK20.29079101
159PAK20.28737406
160CDK10.28617532
161PRKG10.26017293
162CSNK1E0.25963966
163SIK30.25853329
164MAP4K10.25762294
165BMPR1B0.25745378
166JAK10.25581762
167LCK0.24684559
168MAPK80.24589873
169PAK30.22855211
170FGFR20.22788147
171FER0.22551247
172BTK0.22343940
173SCYL20.21838568
174NEK60.20911271
175MAPK30.19258548

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.07421587
2Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.86425272
3Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.56781640
4Steroid biosynthesis_Homo sapiens_hsa001002.14955738
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.06958053
6Sulfur relay system_Homo sapiens_hsa041222.03117294
7Phototransduction_Homo sapiens_hsa0474415.4883950
8RNA polymerase_Homo sapiens_hsa030201.97879548
9Sulfur metabolism_Homo sapiens_hsa009201.87829369
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.85470281
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.74358277
12Staphylococcus aureus infection_Homo sapiens_hsa051501.73686306
13Fatty acid metabolism_Homo sapiens_hsa012121.71031678
14Olfactory transduction_Homo sapiens_hsa047401.62454516
15Synaptic vesicle cycle_Homo sapiens_hsa047211.59552477
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.49067582
17GABAergic synapse_Homo sapiens_hsa047271.45430013
18Complement and coagulation cascades_Homo sapiens_hsa046101.38118902
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.36257024
20Platelet activation_Homo sapiens_hsa046111.34235808
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28513794
22Fatty acid degradation_Homo sapiens_hsa000711.25577595
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23248865
24Renin-angiotensin system_Homo sapiens_hsa046141.21754609
25Glutathione metabolism_Homo sapiens_hsa004801.20843398
26Fatty acid biosynthesis_Homo sapiens_hsa000611.19078232
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04529542
28Fanconi anemia pathway_Homo sapiens_hsa034601.03969674
29Morphine addiction_Homo sapiens_hsa050321.01869493
30Circadian entrainment_Homo sapiens_hsa047130.98652286
31Glutamatergic synapse_Homo sapiens_hsa047240.98534102
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97658557
33Cholinergic synapse_Homo sapiens_hsa047250.97435639
34Peroxisome_Homo sapiens_hsa041460.95806864
35Propanoate metabolism_Homo sapiens_hsa006400.94160044
36Other glycan degradation_Homo sapiens_hsa005110.92556184
37Circadian rhythm_Homo sapiens_hsa047100.91839658
38Caffeine metabolism_Homo sapiens_hsa002320.90884779
39Dopaminergic synapse_Homo sapiens_hsa047280.89382045
40PPAR signaling pathway_Homo sapiens_hsa033200.88493007
41Basal transcription factors_Homo sapiens_hsa030220.87863111
42Phenylalanine metabolism_Homo sapiens_hsa003600.87457399
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86967278
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85316794
45Asthma_Homo sapiens_hsa053100.84817384
46RNA degradation_Homo sapiens_hsa030180.81861433
47Tyrosine metabolism_Homo sapiens_hsa003500.81566677
48Nitrogen metabolism_Homo sapiens_hsa009100.80569899
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78476712
50Serotonergic synapse_Homo sapiens_hsa047260.78385469
51Insulin secretion_Homo sapiens_hsa049110.76737742
52Nicotine addiction_Homo sapiens_hsa050330.76106586
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75952654
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75244201
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73368186
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73330160
57Non-homologous end-joining_Homo sapiens_hsa034500.69375704
58Base excision repair_Homo sapiens_hsa034100.65849060
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65368857
60Retinol metabolism_Homo sapiens_hsa008300.61961499
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.60995839
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60670728
63Oxytocin signaling pathway_Homo sapiens_hsa049210.60621269
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60336373
65Salivary secretion_Homo sapiens_hsa049700.59351365
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59174529
67ABC transporters_Homo sapiens_hsa020100.57898902
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57054355
69N-Glycan biosynthesis_Homo sapiens_hsa005100.56968633
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56944701
71Arginine and proline metabolism_Homo sapiens_hsa003300.56053395
72Long-term potentiation_Homo sapiens_hsa047200.55613478
73Metabolic pathways_Homo sapiens_hsa011000.55447886
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54745243
75Vitamin B6 metabolism_Homo sapiens_hsa007500.54553839
76Gastric acid secretion_Homo sapiens_hsa049710.53219238
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.53000012
78Renin secretion_Homo sapiens_hsa049240.50673548
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50261766
80Hepatitis C_Homo sapiens_hsa051600.50123909
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49409958
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48804398
83Fat digestion and absorption_Homo sapiens_hsa049750.48309224
84Osteoclast differentiation_Homo sapiens_hsa043800.47760363
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47705282
86Dilated cardiomyopathy_Homo sapiens_hsa054140.47477178
87Herpes simplex infection_Homo sapiens_hsa051680.47434831
88Cardiac muscle contraction_Homo sapiens_hsa042600.47308376
89Influenza A_Homo sapiens_hsa051640.46734891
90Toxoplasmosis_Homo sapiens_hsa051450.46356095
91Adherens junction_Homo sapiens_hsa045200.46235888
92Amphetamine addiction_Homo sapiens_hsa050310.44937153
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44414834
94mTOR signaling pathway_Homo sapiens_hsa041500.44065886
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43970668
96Primary immunodeficiency_Homo sapiens_hsa053400.42843333
97cAMP signaling pathway_Homo sapiens_hsa040240.42476540
98Purine metabolism_Homo sapiens_hsa002300.41498355
99Arachidonic acid metabolism_Homo sapiens_hsa005900.40188335
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39785143
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39383770
102Homologous recombination_Homo sapiens_hsa034400.39268502
103Epstein-Barr virus infection_Homo sapiens_hsa051690.39126608
104One carbon pool by folate_Homo sapiens_hsa006700.37744270
105Arginine biosynthesis_Homo sapiens_hsa002200.37636768
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36668191
107Pyrimidine metabolism_Homo sapiens_hsa002400.36207824
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.36079516
109Viral myocarditis_Homo sapiens_hsa054160.33351017
110Calcium signaling pathway_Homo sapiens_hsa040200.33113034
111Cocaine addiction_Homo sapiens_hsa050300.33091482
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30949497
113Autoimmune thyroid disease_Homo sapiens_hsa053200.30856470
114TNF signaling pathway_Homo sapiens_hsa046680.30601484
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30388026
116Glioma_Homo sapiens_hsa052140.29937070
117p53 signaling pathway_Homo sapiens_hsa041150.29515744
118Allograft rejection_Homo sapiens_hsa053300.29271235
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.29055436
120Type II diabetes mellitus_Homo sapiens_hsa049300.28857403
121Glycerolipid metabolism_Homo sapiens_hsa005610.27510658
122GnRH signaling pathway_Homo sapiens_hsa049120.27445511
123Lysosome_Homo sapiens_hsa041420.27441195
124HIF-1 signaling pathway_Homo sapiens_hsa040660.27177544
125Inositol phosphate metabolism_Homo sapiens_hsa005620.26999342
126Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.25927522
127Glucagon signaling pathway_Homo sapiens_hsa049220.25803548
128Endometrial cancer_Homo sapiens_hsa052130.25709012
129Fructose and mannose metabolism_Homo sapiens_hsa000510.25684420
130Pertussis_Homo sapiens_hsa051330.25539098
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.25464055
132Ether lipid metabolism_Homo sapiens_hsa005650.24475409
133RNA transport_Homo sapiens_hsa030130.23812753
134Pancreatic secretion_Homo sapiens_hsa049720.22895702
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.22823663
136Lysine degradation_Homo sapiens_hsa003100.22654345
137Apoptosis_Homo sapiens_hsa042100.22573775
138Measles_Homo sapiens_hsa051620.22563985
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.21981120
140Thyroid hormone synthesis_Homo sapiens_hsa049180.21443915
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21313567
142Leishmaniasis_Homo sapiens_hsa051400.20372268
143Carbon metabolism_Homo sapiens_hsa012000.20256618
144Long-term depression_Homo sapiens_hsa047300.20121856
145Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19821916
146MAPK signaling pathway_Homo sapiens_hsa040100.17907423
147ErbB signaling pathway_Homo sapiens_hsa040120.17638182
148Fatty acid elongation_Homo sapiens_hsa000620.17607489
149Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.17473036
150Vibrio cholerae infection_Homo sapiens_hsa051100.17408627
151Gap junction_Homo sapiens_hsa045400.15921666
152Choline metabolism in cancer_Homo sapiens_hsa052310.15832460
153Alcoholism_Homo sapiens_hsa050340.15783984
154Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15095979
155Tight junction_Homo sapiens_hsa045300.14900080
156Bile secretion_Homo sapiens_hsa049760.14625580
157Chemokine signaling pathway_Homo sapiens_hsa040620.13949469
158Ras signaling pathway_Homo sapiens_hsa040140.13920687
159Longevity regulating pathway - mammal_Homo sapiens_hsa042110.13593711
160Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.13576460
161Melanogenesis_Homo sapiens_hsa049160.13351956
162Phospholipase D signaling pathway_Homo sapiens_hsa040720.12835690
163Wnt signaling pathway_Homo sapiens_hsa043100.12087782
164African trypanosomiasis_Homo sapiens_hsa051430.11733744
165Non-small cell lung cancer_Homo sapiens_hsa052230.11640104
166Drug metabolism - other enzymes_Homo sapiens_hsa009830.11580163
167Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.10635731
168AMPK signaling pathway_Homo sapiens_hsa041520.10415531
169Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10098570
170VEGF signaling pathway_Homo sapiens_hsa043700.09900297
171Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.09706048
172SNARE interactions in vesicular transport_Homo sapiens_hsa041300.09569109
173Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.09535987
174Galactose metabolism_Homo sapiens_hsa000520.09438197
175Collecting duct acid secretion_Homo sapiens_hsa049660.09032216
176Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.09002133
177Insulin resistance_Homo sapiens_hsa049310.07956576
178Taste transduction_Homo sapiens_hsa047420.06672567
179Biosynthesis of amino acids_Homo sapiens_hsa012300.06342234
180Mineral absorption_Homo sapiens_hsa049780.06233167
181Endocytosis_Homo sapiens_hsa041440.04819107

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