ARRB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.13159037
2locomotory exploration behavior (GO:0035641)6.00202316
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.65057108
4positive regulation of gamma-delta T cell activation (GO:0046645)5.50363036
5neutrophil activation involved in immune response (GO:0002283)5.25260071
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.24222857
7vocalization behavior (GO:0071625)4.96367111
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.89929424
9negative regulation of erythrocyte differentiation (GO:0045647)4.84239549
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.76175892
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.72960788
12regulation of synapse structural plasticity (GO:0051823)4.59672357
13glutamate secretion (GO:0014047)4.59614460
14synaptic vesicle exocytosis (GO:0016079)4.58994950
15regulation of synaptic vesicle exocytosis (GO:2000300)4.58563933
16regulation of glutamate receptor signaling pathway (GO:1900449)4.55210560
17positive regulation by organism of defense response of other organism involved in symbiotic interact4.48043103
18modulation by symbiont of host immune response (GO:0052553)4.48043103
19positive regulation by symbiont of host defense response (GO:0052509)4.48043103
20modulation by symbiont of host defense response (GO:0052031)4.48043103
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.48043103
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.48043103
23negative regulation of cell killing (GO:0031342)4.46965560
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.46965560
25sodium ion export (GO:0071436)4.38076405
26response to peptidoglycan (GO:0032494)4.37646878
27layer formation in cerebral cortex (GO:0021819)4.34634855
28exploration behavior (GO:0035640)4.21079453
29regulation of gamma-delta T cell activation (GO:0046643)4.18544049
30ionotropic glutamate receptor signaling pathway (GO:0035235)4.18458277
31proline transport (GO:0015824)4.15938728
32cellular extravasation (GO:0045123)4.14544238
33cellular potassium ion homeostasis (GO:0030007)4.13610718
34regulation of long-term neuronal synaptic plasticity (GO:0048169)4.12370932
35neurotransmitter secretion (GO:0007269)4.10684115
36regulation of synaptic vesicle transport (GO:1902803)4.09249261
37macrophage activation involved in immune response (GO:0002281)4.06209880
38regulation of neuronal synaptic plasticity (GO:0048168)4.02969317
39activation of protein kinase A activity (GO:0034199)3.99540593
40detection of other organism (GO:0098543)3.94795604
41gamma-aminobutyric acid transport (GO:0015812)3.93223273
42regulation of mast cell degranulation (GO:0043304)3.90874266
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.90350545
44glycine transport (GO:0015816)3.86858859
45regulation of gamma-delta T cell differentiation (GO:0045586)3.86586874
46positive regulation of mast cell activation (GO:0033005)3.86169041
47regulation of myeloid leukocyte mediated immunity (GO:0002886)3.78446737
48regulation of ARF protein signal transduction (GO:0032012)3.78214127
49negative regulation of interleukin-12 production (GO:0032695)3.77638393
50protein localization to synapse (GO:0035418)3.75789119
51regulation of leukocyte degranulation (GO:0043300)3.75507573
52positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.75484001
53neuromuscular process controlling balance (GO:0050885)3.73386093
54neuronal action potential propagation (GO:0019227)3.71453964
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.69361824
56neutrophil activation (GO:0042119)3.67613301
57dendritic spine morphogenesis (GO:0060997)3.67119501
58detection of bacterium (GO:0016045)3.66230547
59neurotransmitter-gated ion channel clustering (GO:0072578)3.65434732
60long-term memory (GO:0007616)3.63073326
61antigen processing and presentation of endogenous antigen (GO:0019883)3.62623392
62regulation of mast cell activation involved in immune response (GO:0033006)3.59006617
63regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.56215953
64synaptic transmission, glutamatergic (GO:0035249)3.50584687
65cerebellar Purkinje cell differentiation (GO:0021702)3.50245866
66glutamate receptor signaling pathway (GO:0007215)3.46684160
67antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.45836614
68positive regulation of mast cell activation involved in immune response (GO:0033008)3.45547574
69positive regulation of mast cell degranulation (GO:0043306)3.45547574
70regulation of mast cell activation (GO:0033003)3.43001449
71myeloid cell activation involved in immune response (GO:0002275)3.42484841
72L-amino acid import (GO:0043092)3.42132938
73granulocyte activation (GO:0036230)3.41497182
74regulation of regulated secretory pathway (GO:1903305)3.40148619
75microglial cell activation (GO:0001774)3.40075805
76positive regulation of B cell differentiation (GO:0045579)3.39071339
77regulation of B cell receptor signaling pathway (GO:0050855)3.38135965
78cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.37789417
79response to muramyl dipeptide (GO:0032495)3.35546444
80regulation of excitatory postsynaptic membrane potential (GO:0060079)3.34194287
81prepulse inhibition (GO:0060134)3.33957199
82macrophage activation (GO:0042116)3.33947086
83positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.33718546
84detection of external biotic stimulus (GO:0098581)3.33707450
85synaptic vesicle endocytosis (GO:0048488)3.32676671
86detection of molecule of bacterial origin (GO:0032490)3.32345209
87positive regulation of membrane potential (GO:0045838)3.31918108
88cytoskeletal anchoring at plasma membrane (GO:0007016)3.31552748
89immunoglobulin mediated immune response (GO:0016064)3.31048231
90negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.28173642
91G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.24860477
92dendrite morphogenesis (GO:0048813)3.22966449
93neuron-neuron synaptic transmission (GO:0007270)3.22888047
94neurotransmitter transport (GO:0006836)3.22403067
95response to host immune response (GO:0052572)3.21564228
96response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.21564228
97clathrin coat assembly (GO:0048268)3.21089159
98response to auditory stimulus (GO:0010996)3.20961929
99cell communication by electrical coupling (GO:0010644)3.18419929
100potassium ion import (GO:0010107)3.18048020
101leukocyte migration involved in inflammatory response (GO:0002523)3.17347633
102auditory behavior (GO:0031223)3.17198364
103regulation of dendritic spine morphogenesis (GO:0061001)3.14139395
104positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.14085532
105regulation of postsynaptic membrane potential (GO:0060078)3.13806277
106regulation of synaptic plasticity (GO:0048167)3.13041263
107regulation of clathrin-mediated endocytosis (GO:2000369)3.10312694
108positive regulation of synapse maturation (GO:0090129)3.09471006
109alanine transport (GO:0032328)3.08548221
110vesicle transport along microtubule (GO:0047496)3.07418013
111positive regulation of cellular amide metabolic process (GO:0034250)3.06597674
112neuron cell-cell adhesion (GO:0007158)3.05870907
113mannose metabolic process (GO:0006013)3.05712892
114membrane depolarization during action potential (GO:0086010)3.05180443
115leukocyte degranulation (GO:0043299)3.02118260
116positive regulation of regulated secretory pathway (GO:1903307)3.01963510
117regulation of neurotransmitter levels (GO:0001505)3.01960756
118regulation of neurotransmitter secretion (GO:0046928)3.01187031
119positive regulation of synaptic transmission, GABAergic (GO:0032230)2.99787328
120negative regulation of lymphocyte mediated immunity (GO:0002707)2.99403302
121positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.99268172
122antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.99114418
123positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.97909313
124detection of biotic stimulus (GO:0009595)2.96483974
125regulation of ARF GTPase activity (GO:0032312)2.95094856
126positive regulation of fibroblast migration (GO:0010763)2.93466732
127positive regulation of leukocyte degranulation (GO:0043302)2.93144914
128response to host (GO:0075136)2.91453612
129response to host defenses (GO:0052200)2.91453612
130response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.91453612
131regulation of synaptic transmission, glutamatergic (GO:0051966)2.90910131
132regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.89225891
133cellular response to thyroid hormone stimulus (GO:0097067)2.87822481
134positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.87709178
135negative regulation of T cell mediated immunity (GO:0002710)2.86438776
136cellular sodium ion homeostasis (GO:0006883)2.86328977
137positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.86043401
138positive regulation of neurotransmitter transport (GO:0051590)2.85613381
139negative regulation of leukocyte mediated immunity (GO:0002704)2.85563378
140respiratory burst (GO:0045730)2.85193514
141membrane depolarization (GO:0051899)2.83359120
142regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.83187173
143neuromuscular process controlling posture (GO:0050884)2.82795928
144transmission of nerve impulse (GO:0019226)2.82750444
145lipopolysaccharide-mediated signaling pathway (GO:0031663)2.81718541
146positive regulation of neurotransmitter secretion (GO:0001956)2.81504067
147regulation of platelet aggregation (GO:0090330)2.80115090
148long-term synaptic potentiation (GO:0060291)2.79499244
149actin filament capping (GO:0051693)2.79251319
150regulation of neurotransmitter transport (GO:0051588)2.79038368
151establishment of nucleus localization (GO:0040023)2.77851804
152regulation of T-helper 2 cell differentiation (GO:0045628)2.76211299
153B cell receptor signaling pathway (GO:0050853)2.75203586
154dopamine receptor signaling pathway (GO:0007212)2.74184678
155nerve growth factor signaling pathway (GO:0038180)2.73446068
156neuromuscular process (GO:0050905)2.73180669
157positive thymic T cell selection (GO:0045059)2.72198648
158antigen processing and presentation via MHC class Ib (GO:0002475)2.70950779
159membrane hyperpolarization (GO:0060081)2.69948389
160regulation of dendritic spine development (GO:0060998)2.69123753
161regulation of dendritic cell antigen processing and presentation (GO:0002604)2.68581657
162regulation of interferon-beta biosynthetic process (GO:0045357)2.67942599
163amino acid import (GO:0043090)2.67669174
164positive regulation of synaptic transmission (GO:0050806)2.67420794
165leukocyte aggregation (GO:0070486)2.67307642
166germinal center formation (GO:0002467)2.67003965
167neuronal ion channel clustering (GO:0045161)2.65856830
168potassium ion homeostasis (GO:0055075)2.63480731
169intraspecies interaction between organisms (GO:0051703)2.63444542
170social behavior (GO:0035176)2.63444542
171regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.62620321
172thrombin receptor signaling pathway (GO:0070493)2.62288647
173cAMP biosynthetic process (GO:0006171)2.61479707
174adult walking behavior (GO:0007628)2.61099535
175positive regulation of antigen processing and presentation (GO:0002579)2.60938926
176regulation of vesicle fusion (GO:0031338)2.58963854
177negative regulation of interleukin-17 production (GO:0032700)2.58874505
178neuron recognition (GO:0008038)2.58548895
179actin filament polymerization (GO:0030041)2.58054252
180positive regulation of Rap GTPase activity (GO:0032854)2.57600321
181neutrophil chemotaxis (GO:0030593)2.56870718
182regulation of B cell differentiation (GO:0045577)2.56749860
183negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.55893591
184regulation of platelet activation (GO:0010543)2.55185073
185positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.54322441
186positive regulation of type 2 immune response (GO:0002830)2.52121369
187myeloid leukocyte activation (GO:0002274)2.51846888
188neutrophil migration (GO:1990266)2.49530836
189negative regulation of innate immune response (GO:0045824)2.48879386
190neutrophil mediated immunity (GO:0002446)2.47086649
191regulation of tolerance induction (GO:0002643)2.43702904
192megakaryocyte development (GO:0035855)2.42855963
193regulation of antigen processing and presentation (GO:0002577)2.41899535
194activated T cell proliferation (GO:0050798)2.41449904
195endothelium development (GO:0003158)2.40164924
196negative thymic T cell selection (GO:0045060)2.39732528
197positive regulation of tumor necrosis factor production (GO:0032760)2.39432753
198B cell mediated immunity (GO:0019724)2.38833500
199response to interleukin-15 (GO:0070672)2.38049332

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.54884898
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.35499337
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.05158510
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.15004288
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.10192277
6SCL_19346495_ChIP-Seq_HPC-7_Human3.04168064
7DROSHA_22980978_ChIP-Seq_HELA_Human2.92727836
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.88271924
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.77177850
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.74184345
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.66556181
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.64838905
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.58071356
14VDR_24763502_ChIP-Seq_THP-1_Human2.56211941
15VDR_21846776_ChIP-Seq_THP-1_Human2.54754935
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49994706
17* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.49143865
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.48536621
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.46177794
20* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.39263967
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39193608
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39193608
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.34386401
24* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33871207
25REST_21632747_ChIP-Seq_MESCs_Mouse2.33435837
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30556343
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.24412309
28JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22480189
29* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.19365531
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.18734269
31GBX2_23144817_ChIP-Seq_PC3_Human2.14695858
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14519206
33RUNX_20019798_ChIP-Seq_JUKART_Human2.13585705
34STAT6_21828071_ChIP-Seq_BEAS2B_Human2.08823535
35* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.08165460
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06748923
37* RUNX1_22412390_ChIP-Seq_EML_Mouse2.06511053
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98240138
39* TCF7_22412390_ChIP-Seq_EML_Mouse1.96243386
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.95266681
41* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92930179
42* REST_18959480_ChIP-ChIP_MESCs_Mouse1.92107844
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.92079585
44* SPI1_23547873_ChIP-Seq_NB4_Human1.89985668
45KDM2B_26808549_Chip-Seq_K562_Human1.85500117
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.85332952
47* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.84810845
48* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.81222866
49* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.77197127
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.74519789
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.73967753
52FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.73795141
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.71516774
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71376108
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.69357542
56VDR_24787735_ChIP-Seq_THP-1_Human1.68794240
57AR_21572438_ChIP-Seq_LNCaP_Human1.68729089
58EED_16625203_ChIP-ChIP_MESCs_Mouse1.67665812
59* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66725950
60* MAF_26560356_Chip-Seq_TH1_Human1.65582397
61* ERG_21242973_ChIP-ChIP_JURKAT_Human1.62459373
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.60748617
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.60435948
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59357893
65MYC_22102868_ChIP-Seq_BL_Human1.58985769
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57765815
67UTX_26944678_Chip-Seq_JUKART_Human1.57594929
68* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57197779
69IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.55955840
70* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.54920778
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.54516925
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52894790
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52637825
74* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.51981894
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51933227
76GATA1_19941826_ChIP-Seq_K562_Human1.50591845
77* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48511121
78MYB_26560356_Chip-Seq_TH2_Human1.48040247
79* ELK3_25401928_ChIP-Seq_HUVEC_Human1.44638743
80* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.40577495
81* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39635399
82CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.37388317
83PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36484259
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35811329
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35263678
86SMAD_19615063_ChIP-ChIP_OVARY_Human1.34666783
87ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31584496
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31468019
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28616186
90* KDM2B_26808549_Chip-Seq_DND41_Human1.28541607
91MYB_26560356_Chip-Seq_TH1_Human1.28443572
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27534685
93* GATA1_19941827_ChIP-Seq_MEL_Mouse1.25707871
94PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24370274
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21971480
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21574052
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19132486
98AR_19668381_ChIP-Seq_PC3_Human1.18858214
99ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18125188
100PU_27001747_Chip-Seq_BMDM_Mouse1.17726313
101GATA3_27048872_Chip-Seq_THYMUS_Human1.17488197
102* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17347567
103CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17009624
104* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16852738
105RING1B_27294783_Chip-Seq_ESCs_Mouse1.16140801
106* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15823936
107KDM2B_26808549_Chip-Seq_JURKAT_Human1.15630375
108* MAF_26560356_Chip-Seq_TH2_Human1.15372734
109SMAD4_21799915_ChIP-Seq_A2780_Human1.14551226
110SOX2_21211035_ChIP-Seq_LN229_Gbm1.14308685
111NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11562017
112CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10557483
113LXR_22292898_ChIP-Seq_THP-1_Human1.10509432
114* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.10050107
115TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09603141
116* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08190911
117CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08129726
118AHR_22903824_ChIP-Seq_MCF-7_Human1.07906129
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05807928
120TP53_16413492_ChIP-PET_HCT116_Human1.05265742
121STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05038794
122BCL6_27268052_Chip-Seq_Bcells_Human1.03198238
123EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02631559
124RXR_22108803_ChIP-Seq_LS180_Human1.02562918
125ARNT_22903824_ChIP-Seq_MCF-7_Human1.02105359
126GATA1_22025678_ChIP-Seq_K562_Human1.01896856
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01670055
128NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99720997
129* SPI1_23127762_ChIP-Seq_K562_Human0.99694399
130GATA2_19941826_ChIP-Seq_K562_Human0.99062790
131GATA1_19941827_ChIP-Seq_MEL86_Mouse0.98834744
132ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98018884
133VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97996013
134* BCOR_27268052_Chip-Seq_Bcells_Human0.97605643
135CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97574968
136ESR1_21235772_ChIP-Seq_MCF-7_Human0.97092773
137SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95994913
138ESR1_20079471_ChIP-ChIP_T-47D_Human0.95410429
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94176747
140SPI1_20517297_ChIP-Seq_HL60_Human0.94094969
141PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93609317
142STAT3_23295773_ChIP-Seq_U87_Human0.93484265
143SMAD3_21741376_ChIP-Seq_HESCs_Human0.93360709
144SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92473118
145* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92368956
146* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92261930
147* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92215922
148* TET1_21490601_ChIP-Seq_MESCs_Mouse0.92160555
149* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92016857
150AR_25329375_ChIP-Seq_VCAP_Human0.91941470
151KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91781577
152PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91540873
153CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91398652
154NCOR1_26117541_ChIP-Seq_K562_Human0.91143202
155P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90981366
156NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90691591
157RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90578539
158RING1B_27294783_Chip-Seq_NPCs_Mouse0.90241176
159* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89978884
160SMAD3_21741376_ChIP-Seq_ESCs_Human0.89538192
161P68_20966046_ChIP-Seq_HELA_Human0.89258144
162* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89102671
163SMAD4_21741376_ChIP-Seq_HESCs_Human0.88633699
164CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87604945
165* ESR2_21235772_ChIP-Seq_MCF-7_Human0.87603052
166ZNF274_21170338_ChIP-Seq_K562_Hela0.87091079
167SMC4_20622854_ChIP-Seq_HELA_Human0.86563515
168* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86314857
169CTCF_27219007_Chip-Seq_Bcells_Human0.85673358
170* RACK7_27058665_Chip-Seq_MCF-7_Human0.85525484
171ELF1_20517297_ChIP-Seq_JURKAT_Human0.85307792
172GATA2_21666600_ChIP-Seq_HMVEC_Human0.84760812
173KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.84156923
174TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83669256

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.20266334
2MP0003724_increased_susceptibility_to4.37406301
3MP0003635_abnormal_synaptic_transmissio4.10739504
4MP0003880_abnormal_central_pattern3.43736996
5MP0003436_decreased_susceptibility_to3.42886783
6MP0004270_analgesia3.38560359
7MP0009046_muscle_twitch3.20127129
8MP0009745_abnormal_behavioral_response3.19582475
9MP0002063_abnormal_learning/memory/cond3.13066014
10MP0001968_abnormal_touch/_nociception3.04695253
11MP0002822_catalepsy3.04105502
12MP0002064_seizures3.00978651
13MP0001835_abnormal_antigen_presentation2.92731950
14MP0000569_abnormal_digit_pigmentation2.83493390
15MP0002419_abnormal_innate_immunity2.75077389
16MP0005423_abnormal_somatic_nervous2.70794198
17MP0003191_abnormal_cellular_cholesterol2.66448626
18MP0002572_abnormal_emotion/affect_behav2.47561502
19MP0002734_abnormal_mechanical_nocicepti2.47548130
20MP0005025_abnormal_response_to2.39096079
21MP0001486_abnormal_startle_reflex2.34574126
22MP0000465_gastrointestinal_hemorrhage2.34365147
23MP0002736_abnormal_nociception_after2.26713694
24MP0003828_pulmonary_edema2.26197548
25MP0004858_abnormal_nervous_system2.23339772
26MP0005000_abnormal_immune_tolerance2.22806275
27MP0002735_abnormal_chemical_nociception2.22530740
28MP0009278_abnormal_bone_marrow2.22458496
29MP0002272_abnormal_nervous_system2.19129509
30MP0008569_lethality_at_weaning2.17154993
31MP0009780_abnormal_chondrocyte_physiolo2.15708708
32MP0002148_abnormal_hypersensitivity_rea2.11715986
33MP0006082_CNS_inflammation2.11371900
34MP0002909_abnormal_adrenal_gland2.10472595
35MP0001501_abnormal_sleep_pattern2.09035493
36MP0005671_abnormal_response_to2.07225733
37MP0002733_abnormal_thermal_nociception2.04987402
38MP0005387_immune_system_phenotype2.04555088
39MP0001790_abnormal_immune_system2.04555088
40MP0002723_abnormal_immune_serum2.02559220
41MP0001800_abnormal_humoral_immune1.98633048
42MP0002452_abnormal_antigen_presenting1.97430441
43MP0002420_abnormal_adaptive_immunity1.95449280
44MP0001819_abnormal_immune_cell1.94407327
45MP0004811_abnormal_neuron_physiology1.94194692
46MP0001970_abnormal_pain_threshold1.93910933
47MP0005397_hematopoietic_system_phenotyp1.91473933
48MP0001545_abnormal_hematopoietic_system1.91473933
49MP0001533_abnormal_skeleton_physiology1.90588768
50MP0003656_abnormal_erythrocyte_physiolo1.89389253
51MP0004147_increased_porphyrin_level1.86611567
52MP0009785_altered_susceptibility_to1.86549853
53MP0003329_amyloid_beta_deposits1.86052016
54MP0001440_abnormal_grooming_behavior1.84969929
55MP0005167_abnormal_blood-brain_barrier1.81844900
56MP0000685_abnormal_immune_system1.81645274
57MP0002067_abnormal_sensory_capabilities1.75342424
58MP0003075_altered_response_to1.66745438
59MP0008260_abnormal_autophagy1.65620187
60MP0003633_abnormal_nervous_system1.65194340
61MP0008004_abnormal_stomach_pH1.64954111
62MP0009840_abnormal_foam_cell1.62300856
63MP0003303_peritoneal_inflammation1.61509544
64MP0010155_abnormal_intestine_physiology1.60250857
65MP0003172_abnormal_lysosome_physiology1.60023524
66MP0004885_abnormal_endolymph1.59350459
67MP0004947_skin_inflammation1.58384396
68MP0003690_abnormal_glial_cell1.58160822
69MP0002405_respiratory_system_inflammati1.55808097
70MP0002557_abnormal_social/conspecific_i1.54736930
71MP0004924_abnormal_behavior1.52690198
72MP0005386_behavior/neurological_phenoty1.52690198
73MP0002998_abnormal_bone_remodeling1.50151004
74MP0008961_abnormal_basal_metabolism1.49663103
75MP0002398_abnormal_bone_marrow1.47304821
76MP0003879_abnormal_hair_cell1.46002535
77MP0000716_abnormal_immune_system1.44601124
78MP0001851_eye_inflammation1.43520345
79MP0001845_abnormal_inflammatory_respons1.42839423
80MP0003866_abnormal_defecation1.39316972
81MP0002184_abnormal_innervation1.37298868
82MP0000955_abnormal_spinal_cord1.34883436
83MP0000343_altered_response_to1.33514694
84MP0009764_decreased_sensitivity_to1.31547187
85MP0000604_amyloidosis1.29204171
86MP0003631_nervous_system_phenotype1.28599962
87MP0000778_abnormal_nervous_system1.28313959
88MP0000015_abnormal_ear_pigmentation1.27870500
89MP0004510_myositis1.26902814
90MP0002066_abnormal_motor_capabilities/c1.26819719
91MP0008872_abnormal_physiological_respon1.25088238
92MP0005646_abnormal_pituitary_gland1.23682965
93MP0003763_abnormal_thymus_physiology1.22545670
94MP0002429_abnormal_blood_cell1.20611855
95MP0008469_abnormal_protein_level1.20283923
96MP0000689_abnormal_spleen_morphology1.20109297
97MP0003787_abnormal_imprinting1.19355796
98MP0002882_abnormal_neuron_morphology1.18324903
99MP0008874_decreased_physiological_sensi1.15675042
100MP0003300_gastrointestinal_ulcer1.15443326
101MP0002132_abnormal_respiratory_system1.13820178
102MP0004130_abnormal_muscle_cell1.12103780
103MP0002722_abnormal_immune_system1.11444385
104MP0004883_abnormal_blood_vessel1.08593308
105MP0000858_altered_metastatic_potential1.07459021
106MP0004808_abnormal_hematopoietic_stem1.01360275
107MP0002396_abnormal_hematopoietic_system1.01230420
108MP0005451_abnormal_body_composition1.01073353
109MP0005083_abnormal_biliary_tract1.00431051
110MP0001177_atelectasis0.95358301
111MP0000249_abnormal_blood_vessel0.95098903
112MP0002152_abnormal_brain_morphology0.93619892
113MP0003183_abnormal_peptide_metabolism0.91884645
114MP0003634_abnormal_glial_cell0.91689664
115MP0009115_abnormal_fat_cell0.88761524
116MP0005166_decreased_susceptibility_to0.88651299
117MP0005164_abnormal_response_to0.87565771
118MP0009333_abnormal_splenocyte_physiolog0.87527557
119MP0000920_abnormal_myelination0.86295758
120MP0003632_abnormal_nervous_system0.85998349
121MP0001853_heart_inflammation0.85768768
122MP0005645_abnormal_hypothalamus_physiol0.85654651
123MP0004185_abnormal_adipocyte_glucose0.85583607
124MP0001502_abnormal_circadian_rhythm0.85197041
125MP0005535_abnormal_body_temperature0.85026178
126MP0002229_neurodegeneration0.84772258
127MP0005365_abnormal_bile_salt0.83580682
128MP0003283_abnormal_digestive_organ0.81271968
129MP0010234_abnormal_vibrissa_follicle0.80652754
130MP0002090_abnormal_vision0.80398854
131MP0001663_abnormal_digestive_system0.80353963
132MP0002069_abnormal_eating/drinking_beha0.80311368
133MP0000751_myopathy0.79563703
134MP0000703_abnormal_thymus_morphology0.78962509
135MP0003045_fibrosis0.77831825
136MP0006054_spinal_hemorrhage0.77583333
137MP0000013_abnormal_adipose_tissue0.75596337
138MP0004381_abnormal_hair_follicle0.75375853
139MP0001986_abnormal_taste_sensitivity0.73288167
140MP0001984_abnormal_olfaction0.72990410
141MP0004142_abnormal_muscle_tone0.71135952
142MP0002118_abnormal_lipid_homeostasis0.70193364
143* MP0004085_abnormal_heartbeat0.69306420
144MP0005390_skeleton_phenotype0.68867792
145MP0005666_abnormal_adipose_tissue0.68825227
146MP0005647_abnormal_sex_gland0.67441700
147MP0005165_increased_susceptibility_to0.67120807
148MP0002166_altered_tumor_susceptibility0.66908275
149MP0003091_abnormal_cell_migration0.65322045
150MP0002332_abnormal_exercise_endurance0.65224215
151MP0009763_increased_sensitivity_to0.64914604
152MP0002933_joint_inflammation0.64673945
153MP0002138_abnormal_hepatobiliary_system0.64044333
154MP0002971_abnormal_brown_adipose0.62365366
155MP0005058_abnormal_lysosome_morphology0.62017560
156MP0002089_abnormal_postnatal_growth/wei0.61048492
157MP0003448_altered_tumor_morphology0.60967740
158MP0004484_altered_response_of0.59924304
159MP0006276_abnormal_autonomic_nervous0.55509706
160MP0004742_abnormal_vestibular_system0.54638711
161MP0001664_abnormal_digestion0.54506083
162MP0005409_darkened_coat_color0.53282622
163MP0010386_abnormal_urinary_bladder0.51870934
164MP0005464_abnormal_platelet_physiology0.51641695
165MP0010769_abnormal_survival0.51432039
166MP0001299_abnormal_eye_distance/0.49683185
167MP0001958_emphysema0.48038984
168MP0004215_abnormal_myocardial_fiber0.47496134
169MP0005310_abnormal_salivary_gland0.47143175
170MP0010768_mortality/aging0.46782154
171MP0008770_decreased_survivor_rate0.46676574
172MP0002082_postnatal_lethality0.46304336
173MP0010770_preweaning_lethality0.46304336
174MP0001905_abnormal_dopamine_level0.45001754
175MP0005174_abnormal_tail_pigmentation0.44709934
176MP0005623_abnormal_meninges_morphology0.43796111
177MP0003956_abnormal_body_size0.43693684

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.19553980
2Focal motor seizures (HP:0011153)5.64287962
3Eczematoid dermatitis (HP:0000976)5.24528992
4Recurrent abscess formation (HP:0002722)5.05845252
5Focal seizures (HP:0007359)4.92686920
6Prolonged bleeding time (HP:0003010)4.92099347
7Visual hallucinations (HP:0002367)4.76634825
8Recurrent bacterial skin infections (HP:0005406)4.74219223
9Abnormality of macrophages (HP:0004311)4.66042340
10Action tremor (HP:0002345)4.31268826
11Myositis (HP:0100614)4.09908988
12Spontaneous hematomas (HP:0007420)4.07928951
13Recurrent gram-negative bacterial infections (HP:0005420)3.95327702
14Supranuclear gaze palsy (HP:0000605)3.92997443
15Papilledema (HP:0001085)3.92016408
16Stomatitis (HP:0010280)3.86081270
17Increased neuronal autofluorescent lipopigment (HP:0002074)3.79797421
18Abnormality of liposaccharide metabolism (HP:0010968)3.77690717
19Abnormality of glycosphingolipid metabolism (HP:0004343)3.77690717
20Abnormality of glycolipid metabolism (HP:0010969)3.77690717
21Petechiae (HP:0000967)3.77001359
22Epistaxis (HP:0000421)3.71808414
23Purpura (HP:0000979)3.67247868
24Progressive cerebellar ataxia (HP:0002073)3.65117039
25Orchitis (HP:0100796)3.63985487
26Febrile seizures (HP:0002373)3.49408678
27Insomnia (HP:0100785)3.48019545
28Postural instability (HP:0002172)3.45992544
29Ankle clonus (HP:0011448)3.43781994
30Epileptic encephalopathy (HP:0200134)3.43761897
31Mutism (HP:0002300)3.43189867
32Depression (HP:0000716)3.42176092
33Retrobulbar optic neuritis (HP:0100654)3.40560549
34Optic neuritis (HP:0100653)3.40560549
35Elevated erythrocyte sedimentation rate (HP:0003565)3.32789486
36Hemiplegia (HP:0002301)3.27976436
37Chronic obstructive pulmonary disease (HP:0006510)3.25183581
38Obstructive lung disease (HP:0006536)3.25183581
39Gingival bleeding (HP:0000225)3.24813281
40Generalized tonic-clonic seizures (HP:0002069)3.22192648
41Urinary bladder sphincter dysfunction (HP:0002839)3.20887906
42Dysostosis multiplex (HP:0000943)3.17244564
43Poor eye contact (HP:0000817)3.17159798
44Recurrent fungal infections (HP:0002841)3.14347454
45Impaired social interactions (HP:0000735)3.11375005
46Abnormal social behavior (HP:0012433)3.11375005
47Amyloidosis (HP:0011034)3.07878123
48Atonic seizures (HP:0010819)3.04912551
49Impaired vibration sensation in the lower limbs (HP:0002166)3.02168468
50Abnormality of binocular vision (HP:0011514)3.01745017
51Diplopia (HP:0000651)3.01745017
52Vacuolated lymphocytes (HP:0001922)2.98790638
53Recurrent skin infections (HP:0001581)2.98643161
54Menorrhagia (HP:0000132)2.98028232
55Absence seizures (HP:0002121)2.95067558
56Abnormal platelet volume (HP:0011876)2.93722767
57Gaze-evoked nystagmus (HP:0000640)2.88107626
58Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.86731014
59Truncal ataxia (HP:0002078)2.85317726
60Mediastinal lymphadenopathy (HP:0100721)2.85007089
61Dysdiadochokinesis (HP:0002075)2.84026966
62Annular pancreas (HP:0001734)2.83915322
63Gingivitis (HP:0000230)2.82101113
64Impaired smooth pursuit (HP:0007772)2.79470569
65Dysmetric saccades (HP:0000641)2.77611326
66Broad-based gait (HP:0002136)2.74454842
67Abnormal eating behavior (HP:0100738)2.73552234
68Urinary urgency (HP:0000012)2.72204322
69Intention tremor (HP:0002080)2.69140367
70Anxiety (HP:0000739)2.68994155
71Dialeptic seizures (HP:0011146)2.68193135
72Impaired platelet aggregation (HP:0003540)2.66342198
73Abnormal platelet function (HP:0011869)2.66342198
74Genetic anticipation (HP:0003743)2.65568298
75Pointed chin (HP:0000307)2.65018103
76Dysmetria (HP:0001310)2.62895358
77Abnormality of the lower motor neuron (HP:0002366)2.62020273
78Loss of speech (HP:0002371)2.61738315
79Interstitial pulmonary disease (HP:0006530)2.59963383
80Meningitis (HP:0001287)2.57416915
81Hematochezia (HP:0002573)2.55451784
82Increased mean platelet volume (HP:0011877)2.53999091
83Systemic lupus erythematosus (HP:0002725)2.53029952
84Episodic fever (HP:0001954)2.52944046
85Abnormality of ocular smooth pursuit (HP:0000617)2.50212647
86Gastrointestinal infarctions (HP:0005244)2.50060739
87Encephalitis (HP:0002383)2.48188053
88Recurrent cutaneous fungal infections (HP:0011370)2.47389018
89Chronic mucocutaneous candidiasis (HP:0002728)2.47389018
90Torticollis (HP:0000473)2.46903651
91Poikilocytosis (HP:0004447)2.46881076
92Increased IgE level (HP:0003212)2.46687864
93Stereotypic behavior (HP:0000733)2.46277434
94Neuronal loss in central nervous system (HP:0002529)2.44780173
95Lower limb amyotrophy (HP:0007210)2.44417886
96Increased serum ferritin (HP:0003281)2.43904707
97Hyperacusis (HP:0010780)2.42826510
98Hemoptysis (HP:0002105)2.41448234
99Hemiparesis (HP:0001269)2.40624020
100Bradykinesia (HP:0002067)2.40408507
101Keratoconjunctivitis sicca (HP:0001097)2.39851566
102Abnormality of mucopolysaccharide metabolism (HP:0011020)2.39627728
103Abnormality of polysaccharide metabolism (HP:0011012)2.39627728
104Abnormality of glycosaminoglycan metabolism (HP:0004371)2.39627728
105Vasculitis (HP:0002633)2.38955888
106Cellulitis (HP:0100658)2.37993368
107Chest pain (HP:0100749)2.37828835
108Abnormal delayed hypersensitivity skin test (HP:0002963)2.37624144
109Urticaria (HP:0001025)2.35956880
110Ventricular fibrillation (HP:0001663)2.35180548
111Disinhibition (HP:0000734)2.34818574
112Pulmonary embolism (HP:0002204)2.34044148
113Urinary glycosaminoglycan excretion (HP:0003541)2.33492608
114Mucopolysacchariduria (HP:0008155)2.33492608
115Arterial thrombosis (HP:0004420)2.32479169
116Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.31644986
117Abnormality of iron homeostasis (HP:0011031)2.31108263
118Progressive inability to walk (HP:0002505)2.30826071
119Status epilepticus (HP:0002133)2.29935048
120Pustule (HP:0200039)2.27790722
121Spastic gait (HP:0002064)2.25677969
122Autoimmune thrombocytopenia (HP:0001973)2.25295779
123Keratoconjunctivitis (HP:0001096)2.24651572
124Megalencephaly (HP:0001355)2.23867442
125Apathy (HP:0000741)2.23562146
126Inflammation of the large intestine (HP:0002037)2.23097659
127Cerebral inclusion bodies (HP:0100314)2.22597872
128Resting tremor (HP:0002322)2.22186835
129Scanning speech (HP:0002168)2.21617580
130Gastrointestinal inflammation (HP:0004386)2.20237129
131Inappropriate behavior (HP:0000719)2.18555237
132Leukocytosis (HP:0001974)2.17432682
133Pulmonary infiltrates (HP:0002113)2.16886359
134Bundle branch block (HP:0011710)2.16511717
135Neurofibrillary tangles (HP:0002185)2.15775680
136Myocardial infarction (HP:0001658)2.14584095
137Termporal pattern (HP:0011008)2.13648632
138Insidious onset (HP:0003587)2.13648632
139Increased cerebral lipofuscin (HP:0011813)2.13514376
140Focal dystonia (HP:0004373)2.12928994
141Abnormality of the vasculature of the conjunctiva (HP:0008054)2.12395159
142Lower limb muscle weakness (HP:0007340)2.11463996
143Macroorchidism (HP:0000053)2.10159340
144Elfin facies (HP:0004428)2.09712218
145Vertigo (HP:0002321)2.09331302
146Obstructive sleep apnea (HP:0002870)2.09229762
147Impaired vibratory sensation (HP:0002495)2.08299823
148Rapidly progressive (HP:0003678)2.06822916
149Hepatosplenomegaly (HP:0001433)2.03695467
150Reticulocytosis (HP:0001923)2.03620194
151Clumsiness (HP:0002312)2.03043220
152Abnormality of transition element cation homeostasis (HP:0011030)2.02819502
153Colitis (HP:0002583)2.01844847
154Abnormality of saccadic eye movements (HP:0000570)2.01411372
155Recurrent viral infections (HP:0004429)2.00613686
156Excessive salivation (HP:0003781)1.99252766
157Drooling (HP:0002307)1.99252766
158Slow saccadic eye movements (HP:0000514)1.99199643
159Abnormality of the periventricular white matter (HP:0002518)1.99044356
160Diminished motivation (HP:0000745)1.98673864
161Osteomyelitis (HP:0002754)1.98007057
162Hypochromic anemia (HP:0001931)1.94540959
163Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93051454
164Craniofacial dystonia (HP:0012179)1.91158436
165Spinal canal stenosis (HP:0003416)1.87616937
166Conjunctival telangiectasia (HP:0000524)1.85921969
167Rigidity (HP:0002063)1.85206365
168Ankyloglossia (HP:0010296)1.83370112
169Clonus (HP:0002169)1.83334843
170Amblyopia (HP:0000646)1.82816737
171Hemorrhage of the eye (HP:0011885)1.82359272
172Psychosis (HP:0000709)1.81869154
173Fatigue (HP:0012378)1.81101996
174Granulocytopenia (HP:0001913)1.80649360
175Lower limb asymmetry (HP:0100559)1.79329892
176Aqueductal stenosis (HP:0002410)1.77892610
177Abnormality of the corticospinal tract (HP:0002492)1.76662593
178Incomplete penetrance (HP:0003829)1.75717330
179Upper limb amyotrophy (HP:0009129)1.70421721
180Distal upper limb amyotrophy (HP:0007149)1.70421721
181Agitation (HP:0000713)1.69249969
182Polycythemia (HP:0001901)1.67617304
183Absent speech (HP:0001344)1.65875060
184Gait ataxia (HP:0002066)1.64402759
185Polygenic inheritance (HP:0010982)1.64273467
186Amyotrophic lateral sclerosis (HP:0007354)1.64012839
187Cerebral aneurysm (HP:0004944)1.63365312
188Polyphagia (HP:0002591)1.60862886

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.89685754
2NTRK33.71483865
3EPHA43.56431910
4DAPK23.17481281
5MARK12.88918740
6BLK2.79694289
7MAP4K12.60564900
8CAMKK12.51416087
9MAP3K42.47465323
10MAP2K32.47284192
11MINK12.41547699
12KSR22.33695101
13RIPK42.27783212
14PAK62.17592541
15ZAP702.14996072
16PRKD32.14462588
17TYK22.11174619
18CSK2.02552787
19NTRK21.95788333
20NTRK11.93864380
21SIK21.88826726
22RIPK11.81112013
23BTK1.77941334
24MAP2K71.72895610
25MAP3K111.70318130
26MAP3K141.69735143
27MAP2K41.68682739
28SYK1.65483435
29TAOK11.64041260
30MAP3K31.59559235
31TRIB31.58617937
32STK381.58168426
33ERN11.57707607
34JAK31.55542853
35CDK51.54765481
36GRK61.53485029
37FES1.52857476
38DAPK11.49223073
39LMTK21.48485224
40MAP3K21.46308752
41CAMK1G1.42975634
42IRAK41.41745699
43CSF1R1.40201082
44CAMKK21.40140495
45TEC1.37630496
46RET1.34885492
47KIT1.32577337
48MATK1.31364615
49SGK31.31165319
50PRKCH1.28342125
51ALK1.26128798
52TXK1.25445827
53SCYL21.22029605
54MAP3K131.20971354
55TGFBR21.20498410
56TBK11.17672906
57GRK51.15820309
58EPHB11.10475233
59PHKG21.09723729
60PHKG11.09723729
61TAOK31.09482918
62MAP3K121.07964686
63ITK1.06798507
64LYN1.06285506
65SGK21.05973732
66KSR11.05284723
67LCK1.03880756
68CAMK1D1.02827607
69MAP3K61.02537658
70STK111.00982651
71SGK4940.99983522
72SGK2230.99983522
73TYRO30.99937309
74PDK10.97838178
75PDPK10.94626421
76CAMK10.93110715
77IKBKE0.91901054
78PRKD20.90099057
79DYRK30.89777118
80MAPK130.89038503
81TNIK0.86566698
82STK100.85126386
83PRPF4B0.84891164
84PKN20.84063807
85IKBKB0.81452166
86BMPR20.81236077
87TNK20.79215425
88SGK10.78131440
89MARK20.77010682
90PRKCG0.76772676
91HIPK20.75236170
92TESK20.74620593
93MAP3K10.71239245
94PTK2B0.70347191
95YES10.70331606
96LATS20.70293512
97CDK150.69685849
98KDR0.69521829
99IRAK10.69033259
100MAP3K70.68688357
101CDC42BPA0.68200240
102RPS6KA20.67962439
103UHMK10.67393685
104FYN0.66478358
105CDK180.66003682
106CDK190.64899493
107PLK20.64802208
108WNK10.64304256
109IRAK30.63467533
110DMPK0.61645011
111FGFR30.61353727
112MARK30.60542996
113CAMK40.59991653
114CDK140.59988993
115CDK11A0.57917785
116JAK20.57406519
117PRKD10.56413495
118JAK10.55995146
119BMX0.55301203
120RPS6KC10.55102142
121RPS6KL10.55102142
122RPS6KA30.54113892
123PRKG20.53989691
124FGFR40.52608998
125RAF10.52599981
126TRPM70.52355436
127PIK3CG0.52344588
128EEF2K0.51913336
129PRKCZ0.50391234
130BRSK10.50029697
131MAPK70.50017442
132RPS6KA60.49621539
133PDGFRA0.49517091
134IRAK20.48220704
135PRKCQ0.47977653
136PINK10.47813458
137MAPK120.47258691
138MAPKAPK30.46330045
139TIE10.46141591
140MAPK100.44262085
141FER0.43577261
142MAP2K60.41377908
143EPHA30.40796218
144DAPK30.40098183
145CAMK2A0.39634844
146PTK60.39596156
147HCK0.39352020
148MAP2K10.39215894
149NEK10.39049962
150DYRK1A0.39026097
151FGR0.38984636
152LRRK20.37180736
153ARAF0.36284278
154ICK0.34840043
155MAPK80.33240576
156ERBB20.33033754
157PDGFRB0.31820710
158* SRC0.31289298

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.73204231
2Nicotine addiction_Homo sapiens_hsa050332.54098265
3Other glycan degradation_Homo sapiens_hsa005112.52731762
4Staphylococcus aureus infection_Homo sapiens_hsa051502.41720523
5Leishmaniasis_Homo sapiens_hsa051402.37590050
6* Olfactory transduction_Homo sapiens_hsa047402.24627380
7Circadian entrainment_Homo sapiens_hsa047132.22634852
8Long-term potentiation_Homo sapiens_hsa047202.19352895
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.17086346
10GABAergic synapse_Homo sapiens_hsa047272.15384296
11Glutamatergic synapse_Homo sapiens_hsa047242.11854617
12* Morphine addiction_Homo sapiens_hsa050322.02266272
13Salivary secretion_Homo sapiens_hsa049702.00238184
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99481241
15Nitrogen metabolism_Homo sapiens_hsa009101.90412317
16Gastric acid secretion_Homo sapiens_hsa049711.87183487
17Lysosome_Homo sapiens_hsa041421.86028228
18Amphetamine addiction_Homo sapiens_hsa050311.74032482
19Cholinergic synapse_Homo sapiens_hsa047251.71203674
20Dopaminergic synapse_Homo sapiens_hsa047281.70187525
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70149570
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.68365675
23Acute myeloid leukemia_Homo sapiens_hsa052211.68001903
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.65330890
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.61639272
26Insulin secretion_Homo sapiens_hsa049111.58621558
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55662395
28Graft-versus-host disease_Homo sapiens_hsa053321.55110686
29Renin secretion_Homo sapiens_hsa049241.53270804
30Allograft rejection_Homo sapiens_hsa053301.50254749
31Oxytocin signaling pathway_Homo sapiens_hsa049211.47355769
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.46173495
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43265544
34Type II diabetes mellitus_Homo sapiens_hsa049301.43002517
35Hematopoietic cell lineage_Homo sapiens_hsa046401.41290326
36Malaria_Homo sapiens_hsa051441.39243924
37GnRH signaling pathway_Homo sapiens_hsa049121.39207651
38Long-term depression_Homo sapiens_hsa047301.37314706
39Glioma_Homo sapiens_hsa052141.34697323
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33831392
41Phagosome_Homo sapiens_hsa041451.31454638
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29694933
43Cocaine addiction_Homo sapiens_hsa050301.29001792
44Calcium signaling pathway_Homo sapiens_hsa040201.27620971
45Gap junction_Homo sapiens_hsa045401.27619560
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27087006
47Autoimmune thyroid disease_Homo sapiens_hsa053201.26828126
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26088738
49Toxoplasmosis_Homo sapiens_hsa051451.25923242
50Asthma_Homo sapiens_hsa053101.22839915
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.21995024
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21334140
53Taste transduction_Homo sapiens_hsa047421.20990049
54cAMP signaling pathway_Homo sapiens_hsa040241.19492624
55Estrogen signaling pathway_Homo sapiens_hsa049151.19476091
56Pertussis_Homo sapiens_hsa051331.18920237
57T cell receptor signaling pathway_Homo sapiens_hsa046601.18172864
58NF-kappa B signaling pathway_Homo sapiens_hsa040641.18046619
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16157664
60Dorso-ventral axis formation_Homo sapiens_hsa043201.15269107
61Rheumatoid arthritis_Homo sapiens_hsa053231.13591100
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12909942
63Legionellosis_Homo sapiens_hsa051341.11343538
64TNF signaling pathway_Homo sapiens_hsa046681.10316317
65Intestinal immune network for IgA production_Homo sapiens_hsa046721.07640335
66Phospholipase D signaling pathway_Homo sapiens_hsa040721.07078025
67Antigen processing and presentation_Homo sapiens_hsa046121.04474319
68Serotonergic synapse_Homo sapiens_hsa047261.03020065
69Type I diabetes mellitus_Homo sapiens_hsa049401.03003196
70Influenza A_Homo sapiens_hsa051641.01865154
71ErbB signaling pathway_Homo sapiens_hsa040121.01428593
72Neurotrophin signaling pathway_Homo sapiens_hsa047221.01338552
73Measles_Homo sapiens_hsa051621.00531844
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98196745
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98126862
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97813076
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96646225
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.95034944
79Collecting duct acid secretion_Homo sapiens_hsa049660.93760415
80African trypanosomiasis_Homo sapiens_hsa051430.93705227
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92852549
82VEGF signaling pathway_Homo sapiens_hsa043700.90466595
83Non-small cell lung cancer_Homo sapiens_hsa052230.90300958
84Viral myocarditis_Homo sapiens_hsa054160.86881458
85Hepatitis C_Homo sapiens_hsa051600.85244243
86Pancreatic secretion_Homo sapiens_hsa049720.84921327
87Axon guidance_Homo sapiens_hsa043600.84503992
88mTOR signaling pathway_Homo sapiens_hsa041500.83863687
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83079573
90Melanogenesis_Homo sapiens_hsa049160.82285313
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.81242516
92Choline metabolism in cancer_Homo sapiens_hsa052310.80745174
93Endometrial cancer_Homo sapiens_hsa052130.79731096
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79401461
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79273021
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.78921500
97Hepatitis B_Homo sapiens_hsa051610.77596061
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76220852
99Thyroid hormone synthesis_Homo sapiens_hsa049180.74682767
100Rap1 signaling pathway_Homo sapiens_hsa040150.74566513
101* Endocytosis_Homo sapiens_hsa041440.74250085
102Notch signaling pathway_Homo sapiens_hsa043300.72813727
103Salmonella infection_Homo sapiens_hsa051320.72097182
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.71975808
105Dilated cardiomyopathy_Homo sapiens_hsa054140.71934843
106Platelet activation_Homo sapiens_hsa046110.71518065
107Primary immunodeficiency_Homo sapiens_hsa053400.71445461
108* Chemokine signaling pathway_Homo sapiens_hsa040620.70384098
109Bile secretion_Homo sapiens_hsa049760.70079604
110Shigellosis_Homo sapiens_hsa051310.69935934
111* MAPK signaling pathway_Homo sapiens_hsa040100.69861187
112Herpes simplex infection_Homo sapiens_hsa051680.69017073
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68929448
114Oocyte meiosis_Homo sapiens_hsa041140.67891161
115Amoebiasis_Homo sapiens_hsa051460.67774988
116Inositol phosphate metabolism_Homo sapiens_hsa005620.67629764
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66804432
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64227632
119Renal cell carcinoma_Homo sapiens_hsa052110.62045211
120Insulin signaling pathway_Homo sapiens_hsa049100.61934230
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61381555
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60994640
123Insulin resistance_Homo sapiens_hsa049310.59321364
124Apoptosis_Homo sapiens_hsa042100.59193912
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57704014
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57142611
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56475400
128Chronic myeloid leukemia_Homo sapiens_hsa052200.55028637
129Ras signaling pathway_Homo sapiens_hsa040140.54605842
130Alcoholism_Homo sapiens_hsa050340.53381459
131Prolactin signaling pathway_Homo sapiens_hsa049170.51894481
132Osteoclast differentiation_Homo sapiens_hsa043800.50980235
133Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50523309
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49648290
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49361910
136B cell receptor signaling pathway_Homo sapiens_hsa046620.48799638
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48077993
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47871703
139Pancreatic cancer_Homo sapiens_hsa052120.46559819
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46310342
141HIF-1 signaling pathway_Homo sapiens_hsa040660.45877158
142Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45560654
143Colorectal cancer_Homo sapiens_hsa052100.44909214
144Glucagon signaling pathway_Homo sapiens_hsa049220.44446008
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.43798854
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43213738
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.42357231
148Tuberculosis_Homo sapiens_hsa051520.41948271
149Fatty acid biosynthesis_Homo sapiens_hsa000610.39168929

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