ARRDC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the arrestin family of proteins, which regulate G protein-mediated signaling. The encoded protein is thought to act as a regulator of breast cancer growth and progression by binding to a phosphorylated form of integrin beta4, a tumor-related antigen, targeting the integrin for internalization and degradation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.01203481
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.01203481
3L-phenylalanine metabolic process (GO:0006558)6.38159135
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.38159135
5aromatic amino acid family catabolic process (GO:0009074)5.66200693
6cerebral cortex radially oriented cell migration (GO:0021799)5.22377093
7limb bud formation (GO:0060174)5.17448251
8bile acid biosynthetic process (GO:0006699)5.14215315
9alpha-linolenic acid metabolic process (GO:0036109)5.06685215
10axon ensheathment in central nervous system (GO:0032291)5.05813443
11central nervous system myelination (GO:0022010)5.05813443
12glyoxylate metabolic process (GO:0046487)5.03298172
13response to pheromone (GO:0019236)4.73130422
14neural tube formation (GO:0001841)4.54805577
15fatty acid elongation (GO:0030497)4.54050990
16indolalkylamine catabolic process (GO:0046218)4.52255691
17tryptophan catabolic process (GO:0006569)4.52255691
18indole-containing compound catabolic process (GO:0042436)4.52255691
19DNA double-strand break processing (GO:0000729)4.47800505
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.45181041
21bile acid metabolic process (GO:0008206)4.41755257
22pyrimidine nucleobase catabolic process (GO:0006208)4.38865879
23cysteine metabolic process (GO:0006534)4.37219765
24kynurenine metabolic process (GO:0070189)4.37099801
25microtubule depolymerization (GO:0007019)4.35152345
26replication fork processing (GO:0031297)4.34402921
27tryptophan metabolic process (GO:0006568)4.30719507
28cellular glucuronidation (GO:0052695)4.29240375
29regulation of fibrinolysis (GO:0051917)4.22708771
30peptidyl-glutamic acid carboxylation (GO:0017187)4.22576525
31protein carboxylation (GO:0018214)4.22576525
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.21188066
33sulfur amino acid catabolic process (GO:0000098)4.18053555
34high-density lipoprotein particle remodeling (GO:0034375)4.16823937
35negative regulation of fibrinolysis (GO:0051918)4.16430605
36tyrosine metabolic process (GO:0006570)4.16339695
37regulation of protein activation cascade (GO:2000257)4.14413496
38complement activation, alternative pathway (GO:0006957)4.13952792
39very long-chain fatty acid metabolic process (GO:0000038)4.08817761
40ethanol oxidation (GO:0006069)4.07892828
41intraciliary transport (GO:0042073)4.04780351
42response to nitrosative stress (GO:0051409)3.96423991
43aromatic amino acid family metabolic process (GO:0009072)3.95007376
44regulation of complement activation (GO:0030449)3.89993127
45somite development (GO:0061053)3.87523411
46cellular ketone body metabolic process (GO:0046950)3.85201348
47presynaptic membrane assembly (GO:0097105)3.83933591
48urea metabolic process (GO:0019627)3.83465696
49urea cycle (GO:0000050)3.83465696
50negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.81062510
51negative regulation of translation, ncRNA-mediated (GO:0040033)3.81062510
52regulation of translation, ncRNA-mediated (GO:0045974)3.81062510
53uronic acid metabolic process (GO:0006063)3.78472522
54glucuronate metabolic process (GO:0019585)3.78472522
55negative regulation of lipase activity (GO:0060192)3.70887692
56regulation of triglyceride catabolic process (GO:0010896)3.66225381
57reverse cholesterol transport (GO:0043691)3.65821642
58alpha-amino acid catabolic process (GO:1901606)3.65600756
59triglyceride homeostasis (GO:0070328)3.63580601
60acylglycerol homeostasis (GO:0055090)3.63580601
61coenzyme catabolic process (GO:0009109)3.63225644
62nucleobase catabolic process (GO:0046113)3.62737635
63establishment of nucleus localization (GO:0040023)3.62039272
64central nervous system projection neuron axonogenesis (GO:0021952)3.59618537
65regulation of cholesterol esterification (GO:0010872)3.55277511
66glutamate metabolic process (GO:0006536)3.52467701
67olfactory bulb development (GO:0021772)3.52027108
68amino-acid betaine metabolic process (GO:0006577)3.50075964
69cholesterol efflux (GO:0033344)3.48665153
70benzene-containing compound metabolic process (GO:0042537)3.47694239
71serine family amino acid catabolic process (GO:0009071)3.47088696
72nitrogen cycle metabolic process (GO:0071941)3.47057876
73cerebral cortex cell migration (GO:0021795)3.46157838
74homocysteine metabolic process (GO:0050667)3.45936064
75imidazole-containing compound metabolic process (GO:0052803)3.45679241
76regulation of cholesterol biosynthetic process (GO:0045540)3.43571958
77plasma lipoprotein particle clearance (GO:0034381)3.43048301
78macromolecular complex remodeling (GO:0034367)3.42786650
79plasma lipoprotein particle remodeling (GO:0034369)3.42786650
80protein-lipid complex remodeling (GO:0034368)3.42786650
81fatty-acyl-CoA biosynthetic process (GO:0046949)3.41833620
82cellular amino acid catabolic process (GO:0009063)3.41713334
83phospholipid efflux (GO:0033700)3.41287547
84glial cell proliferation (GO:0014009)3.40249794
85regulation of timing of cell differentiation (GO:0048505)3.39584427
86heme transport (GO:0015886)3.39414640
87ketone body metabolic process (GO:1902224)3.39375052
88bile acid and bile salt transport (GO:0015721)3.33346115
89regulation of bile acid biosynthetic process (GO:0070857)3.32975553
90fibrinolysis (GO:0042730)3.32539272
91long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.31756520
92cellular biogenic amine catabolic process (GO:0042402)3.31550715
93amine catabolic process (GO:0009310)3.31550715
94glycosphingolipid biosynthetic process (GO:0006688)3.31262637
95central nervous system neuron axonogenesis (GO:0021955)3.30107141
96lysine catabolic process (GO:0006554)3.29564264
97lysine metabolic process (GO:0006553)3.29564264
98drug transmembrane transport (GO:0006855)3.29180750
99head development (GO:0060322)3.28798489
100acetyl-CoA metabolic process (GO:0006084)3.27725685
101keratinocyte development (GO:0003334)3.27658820
102ethanol metabolic process (GO:0006067)3.27374777
103negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.25951099
104regulation of development, heterochronic (GO:0040034)3.25579253
105regulation of cholesterol metabolic process (GO:0090181)3.25571041
106hindbrain development (GO:0030902)3.24417168
107short-chain fatty acid metabolic process (GO:0046459)3.23754367
108DNA integration (GO:0015074)3.22553385
109linoleic acid metabolic process (GO:0043651)3.18914245
110positive regulation of fatty acid beta-oxidation (GO:0032000)3.18871718
111very-low-density lipoprotein particle assembly (GO:0034379)3.16705773
112indolalkylamine metabolic process (GO:0006586)3.16634657
113negative regulation of sterol transport (GO:0032372)3.16533416
114negative regulation of cholesterol transport (GO:0032375)3.16533416
115cholesterol homeostasis (GO:0042632)3.13880045
116serine family amino acid metabolic process (GO:0009069)3.13583416
117aspartate family amino acid catabolic process (GO:0009068)3.12114802
118fatty acid oxidation (GO:0019395)3.11772518
119negative regulation of protein activation cascade (GO:2000258)3.10366367
120opsonization (GO:0008228)3.10117618
121serine family amino acid biosynthetic process (GO:0009070)3.09479031
122presynaptic membrane organization (GO:0097090)3.09469765
123sterol homeostasis (GO:0055092)3.08671843
124cilium morphogenesis (GO:0060271)3.08229140
125fatty acid beta-oxidation (GO:0006635)3.07236580
126cofactor catabolic process (GO:0051187)3.07186324
127response to mercury ion (GO:0046689)3.06497068
128carboxylic acid catabolic process (GO:0046395)3.05976747
129organic acid catabolic process (GO:0016054)3.05976747
130cellular modified amino acid catabolic process (GO:0042219)3.05913071
131lipid oxidation (GO:0034440)3.05658202
132histone H2A acetylation (GO:0043968)3.05571409
133atrial cardiac muscle cell action potential (GO:0086014)3.04590893
134protein K11-linked deubiquitination (GO:0035871)3.03698103
135regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.03162804
136epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.01741078
137protein localization to cilium (GO:0061512)3.01186323
138transmission of nerve impulse (GO:0019226)2.99644699
139centriole replication (GO:0007099)2.99400323
140maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.95721054
141sympathetic nervous system development (GO:0048485)2.95348594
142negative regulation of DNA recombination (GO:0045910)2.95210324
143regulation of meiosis I (GO:0060631)2.94888884
144cornea development in camera-type eye (GO:0061303)2.93697179
145retinal ganglion cell axon guidance (GO:0031290)2.90381487
146positive regulation of amino acid transport (GO:0051957)2.88277504
147cilium organization (GO:0044782)2.86803036
148resolution of meiotic recombination intermediates (GO:0000712)2.85853842
149regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.85701807
150cilium assembly (GO:0042384)2.85427331
151establishment of protein localization to Golgi (GO:0072600)2.84421023
152protein polyglutamylation (GO:0018095)2.81872226
153regulation of sarcomere organization (GO:0060297)2.80821537
154neuron cell-cell adhesion (GO:0007158)2.80706457
155regulation of telomere maintenance (GO:0032204)2.80625636
156microtubule polymerization or depolymerization (GO:0031109)2.80369214
157epithelial cilium movement (GO:0003351)2.74186106
158negative regulation of dendrite development (GO:2000171)2.73369925
159otic vesicle formation (GO:0030916)2.72861255
160fucose catabolic process (GO:0019317)2.68001018
161L-fucose metabolic process (GO:0042354)2.68001018
162L-fucose catabolic process (GO:0042355)2.68001018
163positive regulation of oligodendrocyte differentiation (GO:0048714)2.67209810
164embryonic epithelial tube formation (GO:0001838)2.66240789
165germ cell migration (GO:0008354)2.65442252
166RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.63806575
167protein prenylation (GO:0018342)2.62874618
168prenylation (GO:0097354)2.62874618
169regulation of non-canonical Wnt signaling pathway (GO:2000050)2.62237514
170axoneme assembly (GO:0035082)2.61836112
171proline transport (GO:0015824)2.61662795
172vocalization behavior (GO:0071625)2.59514386
173postsynaptic membrane organization (GO:0001941)2.59012159
174behavioral response to ethanol (GO:0048149)2.58891147
175regulation of cilium movement (GO:0003352)2.56898867
176photoreceptor cell maintenance (GO:0045494)2.56890298
177gamma-aminobutyric acid transport (GO:0015812)2.56334124
178regulation of male gonad development (GO:2000018)2.53665420
179protein targeting to Golgi (GO:0000042)2.52972785
180adaptation of signaling pathway (GO:0023058)2.52423901
181positive regulation of male gonad development (GO:2000020)2.51469830
182seminiferous tubule development (GO:0072520)2.50740315
183substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.48274448
184substrate-independent telencephalic tangential migration (GO:0021826)2.48274448
185C-terminal protein amino acid modification (GO:0018410)2.44106103
186negative regulation of mast cell activation (GO:0033004)2.43744132
187positive regulation of cardiac muscle cell differentiation (GO:2000727)2.43670355
188epithelial tube formation (GO:0072175)2.43383029
189microtubule anchoring (GO:0034453)2.42930778
190nucleus localization (GO:0051647)2.41134458
191spermatid nucleus differentiation (GO:0007289)2.40728220
192regulation of collateral sprouting (GO:0048670)2.40613103
193nonmotile primary cilium assembly (GO:0035058)2.40583388
194cellular response to sterol (GO:0036315)2.40419343
195detection of light stimulus involved in visual perception (GO:0050908)2.39775624
196detection of light stimulus involved in sensory perception (GO:0050962)2.39775624
197inner ear receptor stereocilium organization (GO:0060122)2.39667322

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.28950627
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.25583148
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.64221628
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.54624951
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.28826824
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.85232582
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.61297614
8ZNF274_21170338_ChIP-Seq_K562_Hela3.35682989
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.98097129
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.93345181
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.79519564
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.60251517
13IGF1R_20145208_ChIP-Seq_DFB_Human2.50795945
14FUS_26573619_Chip-Seq_HEK293_Human2.47522036
15* EWS_26573619_Chip-Seq_HEK293_Human2.43519182
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.31866319
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.18868363
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.13865178
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07036674
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.98969531
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97878319
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80510188
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80152237
24* SMAD4_21799915_ChIP-Seq_A2780_Human1.79693929
25CLOCK_20551151_ChIP-Seq_293T_Human1.79193710
26ER_23166858_ChIP-Seq_MCF-7_Human1.77876498
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76210677
28EZH2_27294783_Chip-Seq_NPCs_Mouse1.70357564
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.70009873
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.66892560
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63242897
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62935104
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61502659
34CBP_20019798_ChIP-Seq_JUKART_Human1.61502659
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.58954947
36TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.58343444
37FOXA2_19822575_ChIP-Seq_HepG2_Human1.56350956
38STAT3_23295773_ChIP-Seq_U87_Human1.55620199
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.54114270
40AR_25329375_ChIP-Seq_VCAP_Human1.53800682
41NANOG_18555785_Chip-Seq_ESCs_Mouse1.52393535
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.51254169
43* CBX2_27304074_Chip-Seq_ESCs_Mouse1.47875960
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.47413656
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46332094
46EZH2_22144423_ChIP-Seq_EOC_Human1.44505386
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44222231
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44038934
49* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42355905
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41685818
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.41484362
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.39907329
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.39751355
54NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.39751355
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39596428
56* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.39374030
57P53_22387025_ChIP-Seq_ESCs_Mouse1.37132442
58TCF4_23295773_ChIP-Seq_U87_Human1.37018367
59EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36375256
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35502281
61TCF4_22108803_ChIP-Seq_LS180_Human1.34270520
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33552049
63BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33371112
64* TAF15_26573619_Chip-Seq_HEK293_Human1.30431773
65* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29062966
66SALL4_18804426_ChIP-ChIP_XEN_Mouse1.27837275
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27082490
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26247569
69SOX2_19829295_ChIP-Seq_ESCs_Human1.25966359
70NANOG_19829295_ChIP-Seq_ESCs_Human1.25966359
71E2F1_18555785_Chip-Seq_ESCs_Mouse1.25518490
72IRF1_19129219_ChIP-ChIP_H3396_Human1.25437083
73HTT_18923047_ChIP-ChIP_STHdh_Human1.25154481
74CRX_20693478_ChIP-Seq_RETINA_Mouse1.24859529
75* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24567714
76TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.24115006
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23665681
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23665681
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22916422
80ELK1_19687146_ChIP-ChIP_HELA_Human1.22689611
81RNF2_27304074_Chip-Seq_NSC_Mouse1.22659184
82HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22440888
83CMYC_18555785_Chip-Seq_ESCs_Mouse1.22359576
84RUNX2_22187159_ChIP-Seq_PCA_Human1.21707002
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21491028
86TP63_17297297_ChIP-ChIP_HaCaT_Human1.20750817
87* FLI1_21867929_ChIP-Seq_TH2_Mouse1.19843298
88SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19573041
89GBX2_23144817_ChIP-Seq_PC3_Human1.18900961
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18441947
91AHR_22903824_ChIP-Seq_MCF-7_Human1.18227902
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17451133
93FOXO3_23340844_ChIP-Seq_DLD1_Human1.17044403
94FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16971754
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16914471
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16655444
97NOTCH1_21737748_ChIP-Seq_TLL_Human1.15494141
98FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.14523116
99OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13149107
100P300_18555785_Chip-Seq_ESCs_Mouse1.12121691
101ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11908115
102* SOX2_21211035_ChIP-Seq_LN229_Gbm1.11159058
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10780972
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.10386382
105SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09905630
106TRIM28_21343339_ChIP-Seq_HEK293_Human1.09115367
107WT1_19549856_ChIP-ChIP_CCG9911_Human1.08237273
108TP53_22573176_ChIP-Seq_HFKS_Human1.08200266
109ESR1_20079471_ChIP-ChIP_T-47D_Human1.08085687
110AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07842631
111STAT3_18555785_Chip-Seq_ESCs_Mouse1.06415853
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.05604856
113* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05039512
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04419380
115KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03707421
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03675943
117EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03609517
118EST1_17652178_ChIP-ChIP_JURKAT_Human1.02931342
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02875921
120AR_21572438_ChIP-Seq_LNCaP_Human1.02364052
121STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02097231
122RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01824089
123PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00808870
124BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00656737
125SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00130292
126* TP53_18474530_ChIP-ChIP_U2OS_Human0.99071165
127EP300_21415370_ChIP-Seq_HL-1_Mouse0.98902551
128GATA1_22025678_ChIP-Seq_K562_Human0.98071907
129FOXA1_25552417_ChIP-Seq_VCAP_Human0.95663056
130EED_16625203_ChIP-ChIP_MESCs_Mouse0.94935568
131* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94416383
132CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93847352
133STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89593365
134TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89482393
135TP63_23658742_ChIP-Seq_EP156T_Human0.89334879
136SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.87872297
137* SMAD3_21741376_ChIP-Seq_EPCs_Human0.86822857
138* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86567816
139CJUN_26792858_Chip-Seq_BT549_Human0.86079182
140* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85758737
141SOX2_20726797_ChIP-Seq_SW620_Human0.85473380
142* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85154161
143HNF4A_19822575_ChIP-Seq_HepG2_Human0.84464381
144GATA4_25053715_ChIP-Seq_YYC3_Human0.82537108
145BCAT_22108803_ChIP-Seq_LS180_Human0.82244160
146FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81780745
147CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.80563804
148* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.79715086
149NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79564287
150ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79300713
151CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78890429
152SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.78285232
153PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.77961628
154HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.77288267
155WT1_25993318_ChIP-Seq_PODOCYTE_Human0.77233627
156SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.77075839
157MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.76758029
158SMAD4_21741376_ChIP-Seq_EPCs_Human0.75729229
159VDR_22108803_ChIP-Seq_LS180_Human0.75357432
160TP53_16413492_ChIP-PET_HCT116_Human0.75071426
161AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74893169
162MTF2_20144788_ChIP-Seq_MESCs_Mouse0.73890169
163* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.73284365
164EZH2_18974828_ChIP-Seq_MESCs_Mouse0.73163833
165RNF2_18974828_ChIP-Seq_MESCs_Mouse0.73163833
166RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.72983407
167SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.70719461
168CBP_21632823_ChIP-Seq_H3396_Human0.70604994
169CDX2_22108803_ChIP-Seq_LS180_Human0.69925424
170SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.69865673
171* P300_19829295_ChIP-Seq_ESCs_Human0.69540453
172SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.68889658
173TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.68625709

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.85801125
2MP0005360_urolithiasis5.86356697
3MP0005085_abnormal_gallbladder_physiolo5.20895234
4MP0005365_abnormal_bile_salt4.79406247
5MP0008875_abnormal_xenobiotic_pharmacok4.67501650
6MP0003806_abnormal_nucleotide_metabolis3.98796804
7MP0003252_abnormal_bile_duct3.16350202
8MP0002102_abnormal_ear_morphology3.11279074
9MP0003195_calcinosis3.05502479
10MP0003880_abnormal_central_pattern2.91476906
11MP0006292_abnormal_olfactory_placode2.87828638
12MP0002234_abnormal_pharynx_morphology2.84686187
13MP0000569_abnormal_digit_pigmentation2.81455677
14MP0010329_abnormal_lipoprotein_level2.78091491
15MP0000778_abnormal_nervous_system2.46880819
16MP0000516_abnormal_urinary_system2.33944815
17MP0005367_renal/urinary_system_phenotyp2.33944815
18MP0002254_reproductive_system_inflammat2.26248519
19MP0005332_abnormal_amino_acid2.25834310
20MP0002751_abnormal_autonomic_nervous2.15442406
21MP0009840_abnormal_foam_cell2.13534835
22MP0003690_abnormal_glial_cell2.11125896
23MP0001666_abnormal_nutrient_absorption2.10918419
24MP0005083_abnormal_biliary_tract2.07787531
25MP0003787_abnormal_imprinting1.93795088
26MP0004019_abnormal_vitamin_homeostasis1.92105618
27MP0003011_delayed_dark_adaptation1.90695470
28MP0002938_white_spotting1.89439934
29MP0002118_abnormal_lipid_homeostasis1.89087651
30MP0000920_abnormal_myelination1.87933835
31MP0005551_abnormal_eye_electrophysiolog1.86465974
32MP0000631_abnormal_neuroendocrine_gland1.85208369
33MP0003191_abnormal_cellular_cholesterol1.78809468
34MP0005253_abnormal_eye_physiology1.77607975
35MP0008877_abnormal_DNA_methylation1.75774601
36MP0004381_abnormal_hair_follicle1.74419480
37MP0001486_abnormal_startle_reflex1.69629394
38MP0008058_abnormal_DNA_repair1.67580575
39MP0003121_genomic_imprinting1.65371231
40MP0004043_abnormal_pH_regulation1.63599608
41MP0002638_abnormal_pupillary_reflex1.63422583
42MP0010368_abnormal_lymphatic_system1.61809089
43MP0002796_impaired_skin_barrier1.57041402
44MP0002736_abnormal_nociception_after1.54876738
45MP0003950_abnormal_plasma_membrane1.54718147
46MP0010678_abnormal_skin_adnexa1.51834766
47MP0003122_maternal_imprinting1.50168698
48MP0004885_abnormal_endolymph1.49137012
49MP0001968_abnormal_touch/_nociception1.48434178
50MP0005451_abnormal_body_composition1.47980333
51MP0000049_abnormal_middle_ear1.46547348
52MP0003755_abnormal_palate_morphology1.46267504
53MP0000609_abnormal_liver_physiology1.46005056
54MP0005408_hypopigmentation1.45270986
55MP0001986_abnormal_taste_sensitivity1.44170763
56MP0006072_abnormal_retinal_apoptosis1.41084572
57MP0000383_abnormal_hair_follicle1.37450067
58MP0001529_abnormal_vocalization1.36491290
59MP0004484_altered_response_of1.36311600
60MP0009745_abnormal_behavioral_response1.36026541
61MP0008995_early_reproductive_senescence1.34319483
62MP0001293_anophthalmia1.32554465
63MP0002837_dystrophic_cardiac_calcinosis1.31249993
64MP0001984_abnormal_olfaction1.29998400
65MP0002653_abnormal_ependyma_morphology1.29586165
66MP0005646_abnormal_pituitary_gland1.26354507
67MP0001346_abnormal_lacrimal_gland1.26012658
68MP0008789_abnormal_olfactory_epithelium1.25990843
69MP0008057_abnormal_DNA_replication1.25815542
70MP0002138_abnormal_hepatobiliary_system1.25640903
71MP0002272_abnormal_nervous_system1.25413614
72MP0004924_abnormal_behavior1.23917378
73MP0005386_behavior/neurological_phenoty1.23917378
74MP0000566_synostosis1.21731803
75MP0000579_abnormal_nail_morphology1.18673860
76MP0005647_abnormal_sex_gland1.18285585
77MP0006276_abnormal_autonomic_nervous1.17032569
78MP0003567_abnormal_fetal_cardiomyocyte1.13932382
79MP0005584_abnormal_enzyme/coenzyme_acti1.13682379
80MP0009046_muscle_twitch1.13097690
81MP0003938_abnormal_ear_development1.12007193
82MP0000647_abnormal_sebaceous_gland1.11260256
83MP0003718_maternal_effect1.10634021
84MP0003935_abnormal_craniofacial_develop1.09609880
85MP0003868_abnormal_feces_composition1.08759002
86MP0005248_abnormal_Harderian_gland1.08706266
87MP0002735_abnormal_chemical_nociception1.07919055
88MP0004270_analgesia1.05672424
89MP0008872_abnormal_physiological_respon1.04248337
90MP0002282_abnormal_trachea_morphology1.03254103
91MP0000372_irregular_coat_pigmentation1.03216357
92MP0003186_abnormal_redox_activity1.03194564
93MP0001764_abnormal_homeostasis1.02022154
94MP0010030_abnormal_orbit_morphology1.01622728
95MP0005319_abnormal_enzyme/_coenzyme1.01308251
96MP0002168_other_aberrant_phenotype1.00120801
97MP0009643_abnormal_urine_homeostasis0.99218576
98MP0003635_abnormal_synaptic_transmissio0.99181059
99MP0001485_abnormal_pinna_reflex0.98833412
100MP0005391_vision/eye_phenotype0.97017231
101MP0002098_abnormal_vibrissa_morphology0.96942818
102MP0005395_other_phenotype0.96591972
103MP0002184_abnormal_innervation0.95521310
104MP0002557_abnormal_social/conspecific_i0.94269592
105MP0002928_abnormal_bile_duct0.94237707
106MP0002063_abnormal_learning/memory/cond0.94020171
107MP0002572_abnormal_emotion/affect_behav0.93680972
108MP0001177_atelectasis0.93654092
109MP0001286_abnormal_eye_development0.92539524
110MP0001929_abnormal_gametogenesis0.91911062
111MP0000467_abnormal_esophagus_morphology0.91253817
112MP0004215_abnormal_myocardial_fiber0.89633704
113MP0004142_abnormal_muscle_tone0.89587956
114MP0001324_abnormal_eye_pigmentation0.89393866
115MP0002152_abnormal_brain_morphology0.89138477
116MP0002882_abnormal_neuron_morphology0.88513267
117MP0004859_abnormal_synaptic_plasticity0.88371829
118MP0000762_abnormal_tongue_morphology0.87547045
119MP0002064_seizures0.87239454
120MP0003861_abnormal_nervous_system0.87030483
121MP0003136_yellow_coat_color0.86766238
122MP0004133_heterotaxia0.86686879
123MP0000653_abnormal_sex_gland0.85219699
124MP0003632_abnormal_nervous_system0.85042356
125MP0003943_abnormal_hepatobiliary_system0.84569162
126MP0000955_abnormal_spinal_cord0.84484680
127MP0002752_abnormal_somatic_nervous0.84480569
128MP0003329_amyloid_beta_deposits0.84121290
129MP0005394_taste/olfaction_phenotype0.84081938
130MP0005499_abnormal_olfactory_system0.84081938
131MP0003698_abnormal_male_reproductive0.83465088
132MP0001501_abnormal_sleep_pattern0.83341234
133MP0004811_abnormal_neuron_physiology0.83242549
134MP0004272_abnormal_basement_membrane0.82900684
135MP0000639_abnormal_adrenal_gland0.82830370
136MP0000427_abnormal_hair_cycle0.81350627
137MP0003705_abnormal_hypodermis_morpholog0.80073870
138MP0005075_abnormal_melanosome_morpholog0.79711869
139MP0003656_abnormal_erythrocyte_physiolo0.79186481
140MP0000377_abnormal_hair_follicle0.78271489
141MP0003453_abnormal_keratinocyte_physiol0.77687770
142MP0001661_extended_life_span0.77586565
143MP0002060_abnormal_skin_morphology0.76502032
144MP0009053_abnormal_anal_canal0.74949812
145MP0000604_amyloidosis0.73589010
146MP0001340_abnormal_eyelid_morphology0.72882444
147MP0010234_abnormal_vibrissa_follicle0.71011895
148MP0000462_abnormal_digestive_system0.70934570
149MP0002971_abnormal_brown_adipose0.69986004
150MP0009384_cardiac_valve_regurgitation0.68774843
151MP0009765_abnormal_xenobiotic_induced0.68427599
152MP0002295_abnormal_pulmonary_circulatio0.67460589
153MP0005636_abnormal_mineral_homeostasis0.66753194
154MP0004130_abnormal_muscle_cell0.66177810
155MP0009763_increased_sensitivity_to0.65746751
156MP0005501_abnormal_skin_physiology0.64641537
157MP0000537_abnormal_urethra_morphology0.64194433
158MP0000598_abnormal_liver_morphology0.62541529
159MP0003634_abnormal_glial_cell0.59363838
160MP0003631_nervous_system_phenotype0.59021769
161MP0005167_abnormal_blood-brain_barrier0.58242574
162MP0003937_abnormal_limbs/digits/tail_de0.57203661
163MP0002249_abnormal_larynx_morphology0.57026512
164MP0009697_abnormal_copulation0.56943688
165MP0003633_abnormal_nervous_system0.56544210
166MP0005275_abnormal_skin_tensile0.55856123
167MP0004782_abnormal_surfactant_physiolog0.54887410
168MP0002233_abnormal_nose_morphology0.54537951
169MP0004264_abnormal_extraembryonic_tissu0.53326644
170MP0000613_abnormal_salivary_gland0.52831424
171MP0005164_abnormal_response_to0.50888614
172MP0005666_abnormal_adipose_tissue0.50675119
173MP0005334_abnormal_fat_pad0.50633368
174MP0004147_increased_porphyrin_level0.50587300
175MP0005376_homeostasis/metabolism_phenot0.49854734
176MP0005187_abnormal_penis_morphology0.49580743
177MP0001756_abnormal_urination0.47227903
178MP0008438_abnormal_cutaneous_collagen0.47050524
179MP0005195_abnormal_posterior_eye0.46680428
180MP0003638_abnormal_response/metabolism_0.46646445
181MP0005410_abnormal_fertilization0.46012322
182MP0004134_abnormal_chest_morphology0.45718539

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.95569114
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.56292507
3Deep venous thrombosis (HP:0002625)6.06674944
4Xanthomatosis (HP:0000991)5.31143929
5Hyperventilation (HP:0002883)5.15022025
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.13356049
7Prolonged partial thromboplastin time (HP:0003645)5.10017038
8Hyperlipoproteinemia (HP:0010980)4.77958428
9Hypobetalipoproteinemia (HP:0003563)4.54244303
10Complement deficiency (HP:0004431)4.43907064
11Epidermoid cyst (HP:0200040)4.07058775
12Pancreatic cysts (HP:0001737)4.03400246
13Hypolipoproteinemia (HP:0010981)3.88108092
14True hermaphroditism (HP:0010459)3.86461708
15Abnormality of methionine metabolism (HP:0010901)3.85882493
16Hypoalphalipoproteinemia (HP:0003233)3.84806690
17Pancreatic fibrosis (HP:0100732)3.74063699
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.73832839
19Abnormality of aspartate family amino acid metabolism (HP:0010899)3.70480000
20Broad-based gait (HP:0002136)3.66841616
21Fat malabsorption (HP:0002630)3.66257346
22Molar tooth sign on MRI (HP:0002419)3.65930237
23Abnormality of midbrain morphology (HP:0002418)3.65930237
24Ketosis (HP:0001946)3.61157799
25Abnormality of glycine metabolism (HP:0010895)3.60323592
26Abnormality of serine family amino acid metabolism (HP:0010894)3.60323592
27Neurofibrillary tangles (HP:0002185)3.52326803
28Hyperammonemia (HP:0001987)3.50504578
29Absent speech (HP:0001344)3.50289122
30Progressive inability to walk (HP:0002505)3.48164225
31Conjugated hyperbilirubinemia (HP:0002908)3.45206310
32Joint hemorrhage (HP:0005261)3.45103952
33Abnormality of sulfur amino acid metabolism (HP:0004339)3.43629828
34Hyperglycinemia (HP:0002154)3.38539945
35Nephronophthisis (HP:0000090)3.36920730
36Abnormality of the labia minora (HP:0012880)3.28984932
37Abnormality of the common coagulation pathway (HP:0010990)3.18850779
38Medial flaring of the eyebrow (HP:0010747)3.16328621
39Hyperglycinuria (HP:0003108)3.11107950
40Volvulus (HP:0002580)3.06318024
41Abnormality of complement system (HP:0005339)3.05969903
42Drooling (HP:0002307)3.04187369
43Abnormality of glutamine family amino acid metabolism (HP:0010902)3.02495964
44Vascular calcification (HP:0004934)3.02055659
45Hypochromic microcytic anemia (HP:0004840)3.01500377
46Hypercholesterolemia (HP:0003124)2.98655155
47Hypoglycemic coma (HP:0001325)2.92664350
48Chronic hepatic failure (HP:0100626)2.92234073
49Neoplasm of the oral cavity (HP:0100649)2.90177403
50Abnormality of the renal medulla (HP:0100957)2.84473797
51Steatorrhea (HP:0002570)2.83492342
52Abnormality of fatty-acid metabolism (HP:0004359)2.81603373
53Gait imbalance (HP:0002141)2.81588805
54Widely spaced teeth (HP:0000687)2.81526669
55Excessive salivation (HP:0003781)2.81200787
56Congenital primary aphakia (HP:0007707)2.78636269
57Lissencephaly (HP:0001339)2.77491683
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.75148401
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.75148401
60Tented upper lip vermilion (HP:0010804)2.74417884
61Cardiovascular calcification (HP:0011915)2.71836656
62Nephrogenic diabetes insipidus (HP:0009806)2.71156058
63Hypophosphatemic rickets (HP:0004912)2.69026441
64Inability to walk (HP:0002540)2.65406310
65Cystic liver disease (HP:0006706)2.63951103
66Genital tract atresia (HP:0001827)2.61972617
67Intestinal atresia (HP:0011100)2.61870931
68Hepatocellular carcinoma (HP:0001402)2.59338877
69Ketoacidosis (HP:0001993)2.58759920
70Cerebral inclusion bodies (HP:0100314)2.56192871
71Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.56170931
72Rickets (HP:0002748)2.53086984
73Postaxial hand polydactyly (HP:0001162)2.52682806
74Exotropia (HP:0000577)2.52301305
75Abnormality of the renal cortex (HP:0011035)2.50873774
76Febrile seizures (HP:0002373)2.50686072
77Vaginal atresia (HP:0000148)2.50390805
78Delayed CNS myelination (HP:0002188)2.50384355
79Aplasia/Hypoplasia of the tongue (HP:0010295)2.48454918
80Colon cancer (HP:0003003)2.43041051
81Hypokalemic alkalosis (HP:0001949)2.39108745
82Myocardial infarction (HP:0001658)2.38566970
83Narrow forehead (HP:0000341)2.37262203
84Pachygyria (HP:0001302)2.37247071
85Amyloidosis (HP:0011034)2.36313684
86Abnormality of the intrinsic pathway (HP:0010989)2.35531648
87Long nose (HP:0003189)2.34923115
88Hyperbilirubinemia (HP:0002904)2.32955480
89Hypoglycemic seizures (HP:0002173)2.31319444
90Gaze-evoked nystagmus (HP:0000640)2.31268582
91Postaxial foot polydactyly (HP:0001830)2.30744090
92Renal cortical cysts (HP:0000803)2.30097761
93Abnormality of the corticospinal tract (HP:0002492)2.25959239
94Parakeratosis (HP:0001036)2.25952687
95Alkalosis (HP:0001948)2.25516006
96Tubulointerstitial nephritis (HP:0001970)2.23584351
97Enlarged kidneys (HP:0000105)2.23266481
98Focal motor seizures (HP:0011153)2.22239546
99Bifid scrotum (HP:0000048)2.20358323
100Onion bulb formation (HP:0003383)2.16588883
101Type II lissencephaly (HP:0007260)2.16553931
102Abnormality of lateral ventricle (HP:0030047)2.15899226
103Fair hair (HP:0002286)2.14873425
104Spontaneous abortion (HP:0005268)2.12424576
105Irritability (HP:0000737)2.12419817
106Amyotrophic lateral sclerosis (HP:0007354)2.12170901
107Turricephaly (HP:0000262)2.10657994
108Protruding tongue (HP:0010808)2.09561970
109Abnormality of serum amino acid levels (HP:0003112)2.08352248
110Small hand (HP:0200055)2.08037806
111Absent eyebrow (HP:0002223)2.05664833
112Attenuation of retinal blood vessels (HP:0007843)2.04988529
113Cupped ear (HP:0000378)2.04172334
114Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02920305
115Congenital hepatic fibrosis (HP:0002612)2.01898293
116Metabolic acidosis (HP:0001942)2.01004352
117Abnormal biliary tract physiology (HP:0012439)1.98463697
118Bile duct proliferation (HP:0001408)1.98463697
119Abnormal gallbladder morphology (HP:0012437)1.97165228
120Sloping forehead (HP:0000340)1.96934618
121Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.96635739
122Dicarboxylic aciduria (HP:0003215)1.95943257
123Abnormality of dicarboxylic acid metabolism (HP:0010995)1.95943257
124Abnormality of purine metabolism (HP:0004352)1.95530206
125Abnormality of vitamin metabolism (HP:0100508)1.94856826
126Glioma (HP:0009733)1.94368765
127Optic nerve hypoplasia (HP:0000609)1.93850404
128Anencephaly (HP:0002323)1.93553297
129Renal hypoplasia (HP:0000089)1.93012513
130Spastic paraparesis (HP:0002313)1.92661380
131Astrocytoma (HP:0009592)1.91585650
132Abnormality of the astrocytes (HP:0100707)1.91585650
133Abnormality of nucleobase metabolism (HP:0010932)1.91461967
134Megalencephaly (HP:0001355)1.91102370
135Gout (HP:0001997)1.89166841
136Methylmalonic acidemia (HP:0002912)1.88440015
137Pancreatic islet-cell hyperplasia (HP:0004510)1.88429089
138Astigmatism (HP:0000483)1.87977262
139Ependymoma (HP:0002888)1.87806691
140Skin nodule (HP:0200036)1.87492577
141Coronal craniosynostosis (HP:0004440)1.86584133
142Peripheral demyelination (HP:0011096)1.86579115
143Abnormality of the ischium (HP:0003174)1.85825383
144Intention tremor (HP:0002080)1.84426495
145Abnormality of pyrimidine metabolism (HP:0004353)1.83325488
146Poor coordination (HP:0002370)1.82848058
147Prominent nasal bridge (HP:0000426)1.82609808
148Confusion (HP:0001289)1.80792848
149Hypoplastic ischia (HP:0003175)1.80417065
150Opisthotonus (HP:0002179)1.80003738
151Hyperinsulinemic hypoglycemia (HP:0000825)1.79724281
152Aplasia/Hypoplasia of the uvula (HP:0010293)1.79310343
153Short foot (HP:0001773)1.78915810
154Glomerulosclerosis (HP:0000096)1.78841549
155Abnormal tarsal ossification (HP:0008369)1.78785032
156Aplasia/Hypoplasia of the tibia (HP:0005772)1.78288565
157Alacrima (HP:0000522)1.78199287
158Abnormality of chromosome stability (HP:0003220)1.78074823
159Conical tooth (HP:0000698)1.77491954
160Stomach cancer (HP:0012126)1.77005151
161Metabolic alkalosis (HP:0200114)1.76812925
162Clubbing of toes (HP:0100760)1.76756711
163Focal seizures (HP:0007359)1.75749464
164Furrowed tongue (HP:0000221)1.75089608
165Congenital stationary night blindness (HP:0007642)1.75036325
166Hemorrhage of the eye (HP:0011885)1.74437857
167Hypothermia (HP:0002045)1.73360650
168Systemic lupus erythematosus (HP:0002725)1.73351924
169Hypoplastic iliac wings (HP:0002866)1.72295608
170Male pseudohermaphroditism (HP:0000037)1.72231001
171Cerebellar dysplasia (HP:0007033)1.71955381
172Cholelithiasis (HP:0001081)1.71384621
173Decreased testicular size (HP:0008734)1.71305216
174Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.71102185
175Short 4th metacarpal (HP:0010044)1.71102185
176Lethargy (HP:0001254)1.69739639
177Gastroesophageal reflux (HP:0002020)1.69608886
178Micropenis (HP:0000054)1.69478348
179Dandy-Walker malformation (HP:0001305)1.69377178
180Intellectual disability, progressive (HP:0006887)1.69318582
181Axonal loss (HP:0003447)1.69208505
182Atonic seizures (HP:0010819)1.68888692
183Hyporeflexia of lower limbs (HP:0002600)1.68884727
184Bifid tongue (HP:0010297)1.67636800
185Preaxial hand polydactyly (HP:0001177)1.67155813
186Bulbous nose (HP:0000414)1.67080378
187Broad foot (HP:0001769)1.66999077
188Dyskinesia (HP:0100660)1.66981587
189Acanthocytosis (HP:0001927)1.66872589
190Hemiparesis (HP:0001269)1.66849468
191Scanning speech (HP:0002168)1.66321388
192Abnormality of the gallbladder (HP:0005264)1.65872408
193Spastic diplegia (HP:0001264)1.64909441
194Abnormal enzyme/coenzyme activity (HP:0012379)1.64311237
195Aplasia involving bones of the extremities (HP:0009825)1.63488898
196Aplasia involving bones of the upper limbs (HP:0009823)1.63488898
197Aplasia of the phalanges of the hand (HP:0009802)1.63488898
198Abnormal gallbladder physiology (HP:0012438)1.62007784
199Cholecystitis (HP:0001082)1.62007784

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR23.96672216
2STK393.89567128
3EPHB13.40072177
4OXSR13.17100404
5MAP4K23.07809388
6SIK13.07622920
7TNIK2.91754530
8MAPK132.87617573
9BCKDK2.77310131
10TRIM282.70981916
11MET2.62581277
12PKN12.42353432
13BRD42.42258507
14FGFR42.33868013
15MAPK152.21694507
16PNCK2.14271711
17BRSK22.11720150
18LATS12.09910395
19WNK42.09573968
20INSRR2.05897281
21EPHA42.00383947
22MAP3K41.97667919
23ERBB41.90996371
24AKT31.89795251
25SGK2231.84668915
26SGK4941.84668915
27EIF2AK31.80367237
28MKNK21.75059529
29PBK1.70637543
30WEE11.65458711
31BCR1.64221753
32MST1R1.61961289
33MAPKAPK51.59342662
34CSNK1A1L1.58349547
35TAOK31.46716878
36WNK11.36775735
37MKNK11.35356931
38EPHB21.34995429
39SIK31.30636349
40TIE11.28580338
41GSK3A1.28298115
42CSNK1G11.27927356
43PAK31.27336327
44CSNK1G31.22896884
45CCNB11.21844092
46PLK31.20898714
47EPHA31.20077385
48STK38L1.11224239
49NLK1.10027176
50TGFBR21.08991715
51ACVR1B1.06975202
52MAP2K71.06809823
53WNK31.05270795
54DYRK1B1.02789808
55NEK61.02237181
56PLK41.01209364
57MAP3K21.01024671
58CSNK1G20.99896837
59DYRK20.99683595
60ADRBK20.99330275
61PLK20.95834428
62DYRK30.94124842
63CAMK2B0.94102903
64CAMK2G0.91931194
65MARK30.91620742
66PRKD10.90977317
67ERN10.90794849
68ERBB20.90713356
69PINK10.89257117
70NUAK10.89089962
71PTK60.88837445
72NTRK30.88478892
73PRKAA20.87471345
74SIK20.86689727
75BMPR1B0.85301774
76VRK10.84478179
77MAPK70.83712987
78IRAK20.83349142
79PIK3CG0.82830443
80DAPK20.82690192
81CDK30.82068697
82ZAK0.81827068
83FRK0.80116426
84PHKG20.79498260
85PHKG10.79498260
86MAP3K30.77431091
87MAP2K20.77115384
88MARK10.76499124
89FER0.74958879
90MAP3K70.68971732
91LIMK10.68874296
92RPS6KA40.68610806
93PDK20.66749183
94FGFR10.66419274
95PIK3CA0.66403952
96SRPK10.66338004
97CAMK2D0.66027786
98TYRO30.65540013
99SGK30.65433029
100UHMK10.64741724
101ERBB30.64567293
102MAPK110.64355789
103CAMK1D0.62149547
104ICK0.61708328
105PRKCG0.61473383
106GRK70.60922861
107SGK20.57941248
108IRAK10.57923068
109CAMK2A0.57623859
110PDPK10.56973829
111FGFR30.56724601
112CSNK1D0.53715036
113TRPM70.53573910
114EPHA20.52424196
115OBSCN0.52221585
116HIPK20.51804956
117GRK10.51794104
118MINK10.51665038
119PLK10.51576992
120MAP2K40.51539544
121ATM0.51523565
122PRKCQ0.50988391
123MAPK40.50870759
124MAPK120.50602617
125YES10.49885616
126EIF2AK10.49313627
127ROCK20.48617610
128CAMKK20.47657933
129DYRK1A0.46994966
130NTRK20.46764777
131CDK60.46222129
132CAMK1G0.45973314
133PRKCE0.44719895
134MST40.44600091
135STK30.44459942
136MARK20.44098320
137ABL10.43834919
138TSSK60.43682996
139CLK10.43531889
140RPS6KA50.42231839
141LMTK20.41830615
142NTRK10.40466129
143PRKCZ0.39613084
144TGFBR10.39585277
145PRKG10.39369914
146CDC42BPA0.39103280
147RET0.38332610
148CAMK40.37796505
149CASK0.37719153
150ROCK10.37028105
151ADRBK10.37008607
152KSR10.36826816
153FLT30.35755379
154CSNK1A10.35224747
155CHUK0.27529549
156PRKDC0.26366123
157EIF2AK20.25496976
158GRK50.24190358
159ATR0.23839287
160STK110.23279060

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.96155814
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.91756904
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.97132982
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.94644646
5Non-homologous end-joining_Homo sapiens_hsa034502.92302014
6Fanconi anemia pathway_Homo sapiens_hsa034602.84192454
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.58674326
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.47861796
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45098984
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40322396
11Phototransduction_Homo sapiens_hsa047442.37788326
12Butanoate metabolism_Homo sapiens_hsa006502.37614847
13Nicotine addiction_Homo sapiens_hsa050332.37574493
14Fatty acid degradation_Homo sapiens_hsa000712.37135828
15Complement and coagulation cascades_Homo sapiens_hsa046102.35560083
16Histidine metabolism_Homo sapiens_hsa003402.32395644
17Tryptophan metabolism_Homo sapiens_hsa003802.29944187
18Arginine biosynthesis_Homo sapiens_hsa002202.29693715
19Fatty acid elongation_Homo sapiens_hsa000622.24752385
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.19378448
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.16261401
22Steroid hormone biosynthesis_Homo sapiens_hsa001402.14925987
23Chemical carcinogenesis_Homo sapiens_hsa052042.13073460
24Taste transduction_Homo sapiens_hsa047422.00999932
25Propanoate metabolism_Homo sapiens_hsa006401.99794709
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.99771458
27Sulfur metabolism_Homo sapiens_hsa009201.98579362
28Peroxisome_Homo sapiens_hsa041461.98516197
29Protein export_Homo sapiens_hsa030601.95949499
30Steroid biosynthesis_Homo sapiens_hsa001001.95573759
31Fatty acid metabolism_Homo sapiens_hsa012121.92137731
32Retinol metabolism_Homo sapiens_hsa008301.87421298
33PPAR signaling pathway_Homo sapiens_hsa033201.78065953
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.74814860
35Basal transcription factors_Homo sapiens_hsa030221.72969497
36Homologous recombination_Homo sapiens_hsa034401.69864258
37Regulation of autophagy_Homo sapiens_hsa041401.62657815
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60204702
39beta-Alanine metabolism_Homo sapiens_hsa004101.59554709
40ABC transporters_Homo sapiens_hsa020101.53917077
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.52187318
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49209762
43Tyrosine metabolism_Homo sapiens_hsa003501.48238404
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46485507
45Selenocompound metabolism_Homo sapiens_hsa004501.45105288
46RNA degradation_Homo sapiens_hsa030181.44588532
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42808859
48Bile secretion_Homo sapiens_hsa049761.41300872
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39485701
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39114763
51Drug metabolism - other enzymes_Homo sapiens_hsa009831.37978686
52Circadian rhythm_Homo sapiens_hsa047101.36078264
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.32132369
54Phenylalanine metabolism_Homo sapiens_hsa003601.30405666
55Caffeine metabolism_Homo sapiens_hsa002321.28062639
56Staphylococcus aureus infection_Homo sapiens_hsa051501.26664419
57Circadian entrainment_Homo sapiens_hsa047131.26249605
58Vitamin B6 metabolism_Homo sapiens_hsa007501.25781613
59Morphine addiction_Homo sapiens_hsa050321.19527261
60Collecting duct acid secretion_Homo sapiens_hsa049661.18808771
61GABAergic synapse_Homo sapiens_hsa047271.18380609
62Dopaminergic synapse_Homo sapiens_hsa047281.15893746
63Maturity onset diabetes of the young_Homo sapiens_hsa049501.14215336
64Olfactory transduction_Homo sapiens_hsa047401.10329896
65Starch and sucrose metabolism_Homo sapiens_hsa005001.09610380
66Folate biosynthesis_Homo sapiens_hsa007901.09381688
67Glutamatergic synapse_Homo sapiens_hsa047241.07626017
68Insulin secretion_Homo sapiens_hsa049111.06541159
69Pyruvate metabolism_Homo sapiens_hsa006201.04529615
70Arginine and proline metabolism_Homo sapiens_hsa003301.02882113
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99503217
72Oocyte meiosis_Homo sapiens_hsa041140.98380442
73Glutathione metabolism_Homo sapiens_hsa004800.94761661
74Fatty acid biosynthesis_Homo sapiens_hsa000610.90962953
75Amphetamine addiction_Homo sapiens_hsa050310.90864405
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90333263
77Fat digestion and absorption_Homo sapiens_hsa049750.89519842
78Vitamin digestion and absorption_Homo sapiens_hsa049770.85111343
79Salivary secretion_Homo sapiens_hsa049700.80313480
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79423106
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78435309
82Cocaine addiction_Homo sapiens_hsa050300.78411794
83Lysine degradation_Homo sapiens_hsa003100.76142324
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.75104087
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72110009
86Renin secretion_Homo sapiens_hsa049240.71674843
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70605098
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69237266
89p53 signaling pathway_Homo sapiens_hsa041150.67244475
90Linoleic acid metabolism_Homo sapiens_hsa005910.65066701
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.63628485
92Long-term depression_Homo sapiens_hsa047300.63402379
93Serotonergic synapse_Homo sapiens_hsa047260.63038758
94Ether lipid metabolism_Homo sapiens_hsa005650.61250732
95Hippo signaling pathway_Homo sapiens_hsa043900.59228343
96Glycerolipid metabolism_Homo sapiens_hsa005610.58325731
97FoxO signaling pathway_Homo sapiens_hsa040680.58250191
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56483812
99Biosynthesis of amino acids_Homo sapiens_hsa012300.55240628
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53197369
101Colorectal cancer_Homo sapiens_hsa052100.52336198
102Wnt signaling pathway_Homo sapiens_hsa043100.52318662
103Alcoholism_Homo sapiens_hsa050340.51093711
104Carbon metabolism_Homo sapiens_hsa012000.50249066
105Prion diseases_Homo sapiens_hsa050200.49630894
106cAMP signaling pathway_Homo sapiens_hsa040240.48018734
107RNA transport_Homo sapiens_hsa030130.47104180
108RNA polymerase_Homo sapiens_hsa030200.44979891
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41769176
110Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40981280
111Metabolic pathways_Homo sapiens_hsa011000.37174853
112Calcium signaling pathway_Homo sapiens_hsa040200.35945931
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35292210
114Cholinergic synapse_Homo sapiens_hsa047250.34346824
115Type II diabetes mellitus_Homo sapiens_hsa049300.31309481
116Cell cycle_Homo sapiens_hsa041100.30956283
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30857175
118Legionellosis_Homo sapiens_hsa051340.29733105
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29346116
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28538734
121Insulin resistance_Homo sapiens_hsa049310.28445973
122Sulfur relay system_Homo sapiens_hsa041220.25730061
123Melanogenesis_Homo sapiens_hsa049160.25566697
124Axon guidance_Homo sapiens_hsa043600.24901631
125Nucleotide excision repair_Homo sapiens_hsa034200.24354112
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.22360575
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.19702966
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.18409025
129Ovarian steroidogenesis_Homo sapiens_hsa049130.18219088
130Systemic lupus erythematosus_Homo sapiens_hsa053220.17647490
131Arachidonic acid metabolism_Homo sapiens_hsa005900.16658976
132Sphingolipid metabolism_Homo sapiens_hsa006000.16243355
133Tight junction_Homo sapiens_hsa045300.15543618
134ECM-receptor interaction_Homo sapiens_hsa045120.13638189
135AMPK signaling pathway_Homo sapiens_hsa041520.10810463
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.08055855
137Mineral absorption_Homo sapiens_hsa049780.06305476
138Basal cell carcinoma_Homo sapiens_hsa052170.04564791
139One carbon pool by folate_Homo sapiens_hsa006700.03944244
140Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.02930521
141Protein digestion and absorption_Homo sapiens_hsa049740.02585805
142Amoebiasis_Homo sapiens_hsa051460.00964874
143Glucagon signaling pathway_Homo sapiens_hsa049220.00109032
144Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0746198
145Pentose phosphate pathway_Homo sapiens_hsa00030-0.0708513
146Hepatitis C_Homo sapiens_hsa05160-0.0690166
147Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0676444
148Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0632704
149Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0589824
150TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0513322
151Hedgehog signaling pathway_Homo sapiens_hsa04340-0.0379715
152Renal cell carcinoma_Homo sapiens_hsa05211-0.0230213
153Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0060203

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