ARRDC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.90478523
2spermatid development (GO:0007286)9.60893460
3axonemal dynein complex assembly (GO:0070286)9.55753313
4epithelial cilium movement (GO:0003351)9.55342169
5reproduction (GO:0000003)9.45386860
6motile cilium assembly (GO:0044458)8.97275363
7cilium or flagellum-dependent cell motility (GO:0001539)8.53445731
8regulation of cilium movement (GO:0003352)8.37211617
9cilium movement (GO:0003341)7.80863713
10synaptonemal complex assembly (GO:0007130)7.48792921
11synaptonemal complex organization (GO:0070193)7.46917897
12male meiosis (GO:0007140)7.43280238
13single fertilization (GO:0007338)7.34188588
14sperm capacitation (GO:0048240)7.23093546
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.21967424
16piRNA metabolic process (GO:0034587)7.14342861
17negative regulation of inclusion body assembly (GO:0090084)6.86683701
18spermatogenesis (GO:0007283)6.70759450
19male gamete generation (GO:0048232)6.68404324
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.61475262
21positive regulation of gamma-delta T cell activation (GO:0046645)6.58743839
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.48214422
23negative regulation of cell killing (GO:0031342)6.48214422
24microtubule depolymerization (GO:0007019)6.42241307
25regulation of B cell receptor signaling pathway (GO:0050855)6.32058772
26organic cation transport (GO:0015695)6.30261652
27fertilization (GO:0009566)6.27914786
28gamete generation (GO:0007276)6.17822934
29regulation of inclusion body assembly (GO:0090083)5.80073767
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.39795330
31cellular process involved in reproduction in multicellular organism (GO:0022412)5.39474684
32calcium ion-dependent exocytosis (GO:0017156)5.37935321
33germ cell development (GO:0007281)5.34841547
34chromosome condensation (GO:0030261)5.33817674
35negative T cell selection (GO:0043383)5.27626660
36microtubule severing (GO:0051013)5.25486585
37positive thymic T cell selection (GO:0045059)5.22940834
38spermatid nucleus differentiation (GO:0007289)5.22380603
39negative thymic T cell selection (GO:0045060)5.17774253
40positive T cell selection (GO:0043368)5.12096746
41chromosome organization involved in meiosis (GO:0070192)5.10476708
42DNA packaging (GO:0006323)5.04141330
43cell recognition (GO:0008037)5.01491968
44response to interleukin-15 (GO:0070672)4.95473415
45ventricular system development (GO:0021591)4.91633731
46regulation of microtubule-based movement (GO:0060632)4.86460682
47multicellular organismal reproductive process (GO:0048609)4.84495627
48male meiosis I (GO:0007141)4.83480241
49cellular response to interleukin-15 (GO:0071350)4.80958301
50glycerol ether metabolic process (GO:0006662)4.71180634
51regulation of gamma-delta T cell activation (GO:0046643)4.67240426
52DNA methylation involved in gamete generation (GO:0043046)4.64452687
53regulation of gamma-delta T cell differentiation (GO:0045586)4.58970960
54seminiferous tubule development (GO:0072520)4.58358448
55antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.55105682
56regulation of B cell differentiation (GO:0045577)4.53317610
57T cell selection (GO:0045058)4.51236245
58thymic T cell selection (GO:0045061)4.49886898
59antigen processing and presentation of endogenous antigen (GO:0019883)4.46184713
60negative regulation of T cell mediated immunity (GO:0002710)4.45170248
61T cell migration (GO:0072678)4.44406213
62meiotic nuclear division (GO:0007126)4.42350348
63ether metabolic process (GO:0018904)4.35103530
64activated T cell proliferation (GO:0050798)4.34117347
65positive regulation of granulocyte differentiation (GO:0030854)4.26540294
66single strand break repair (GO:0000012)4.24848764
67positive regulation by symbiont of host defense response (GO:0052509)4.24560323
68modulation by symbiont of host defense response (GO:0052031)4.24560323
69modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.24560323
70modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.24560323
71positive regulation by organism of defense response of other organism involved in symbiotic interact4.24560323
72modulation by symbiont of host immune response (GO:0052553)4.24560323
73negative regulation of lymphocyte mediated immunity (GO:0002707)4.10316158
74positive regulation of B cell differentiation (GO:0045579)4.04666239
75sexual reproduction (GO:0019953)4.02393142
76antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.02109930
77B cell receptor signaling pathway (GO:0050853)4.00178142
78cytidine metabolic process (GO:0046087)3.98801291
79cytidine catabolic process (GO:0006216)3.98801291
80cytidine deamination (GO:0009972)3.98801291
81chaperone-mediated protein complex assembly (GO:0051131)3.98018344
82left/right pattern formation (GO:0060972)3.97735862
83meiosis I (GO:0007127)3.96507530
84negative regulation of interleukin-12 production (GO:0032695)3.94945765
85macrophage activation involved in immune response (GO:0002281)3.92870385
86megakaryocyte development (GO:0035855)3.91956388
87monoubiquitinated protein deubiquitination (GO:0035520)3.87996641
88multicellular organismal development (GO:0007275)3.87095045
89regulation of regulatory T cell differentiation (GO:0045589)3.86842549
90leukocyte aggregation (GO:0070486)3.83032068
91protein polyglutamylation (GO:0018095)3.82927162
92signal complex assembly (GO:0007172)3.79372244
93DNA deamination (GO:0045006)3.78507701
94positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.75301572
95sequestering of actin monomers (GO:0042989)3.74871827
96pyrimidine ribonucleoside catabolic process (GO:0046133)3.73133541
97regulation of alpha-beta T cell proliferation (GO:0046640)3.71470263
98negative regulation of leukocyte mediated immunity (GO:0002704)3.67548811
99neutrophil activation involved in immune response (GO:0002283)3.67251793
100genitalia morphogenesis (GO:0035112)3.59266241
101meiotic cell cycle (GO:0051321)3.58878440
102regulation of T cell tolerance induction (GO:0002664)3.58038374
103neutrophil activation (GO:0042119)3.57992740
104regulation of T cell mediated cytotoxicity (GO:0001914)3.56570121
105positive regulation of alpha-beta T cell proliferation (GO:0046641)3.56548439
106regulation of spindle checkpoint (GO:0090231)3.54400471
107protein K11-linked deubiquitination (GO:0035871)3.53980890
108antigen receptor-mediated signaling pathway (GO:0050851)3.52134906
109microglial cell activation (GO:0001774)3.48501741
110positive regulation of T cell mediated cytotoxicity (GO:0001916)3.43148948
111T cell receptor signaling pathway (GO:0050852)3.38767561
112regulation of tolerance induction (GO:0002643)3.38301836
113regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.37164746
114regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.36715621
115granulocyte activation (GO:0036230)3.36278500
116microtubule polymerization or depolymerization (GO:0031109)3.35304230
117detection of other organism (GO:0098543)3.27899943
118positive regulation of tolerance induction (GO:0002645)3.27571301
119regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.27148220
120antigen processing and presentation via MHC class Ib (GO:0002475)3.26836270
121detection of bacterium (GO:0016045)3.25647318
122negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.24377633
123regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.23379664
124regulation of natural killer cell mediated immunity (GO:0002715)3.23379664
125cellular response to type I interferon (GO:0071357)3.23241736
126type I interferon signaling pathway (GO:0060337)3.23241736
127tolerance induction (GO:0002507)3.21773384
128response to type I interferon (GO:0034340)3.21102881
129interferon-gamma production (GO:0032609)3.16725870
130negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.15043455
131dendritic cell chemotaxis (GO:0002407)3.14869878
132regulation of leukocyte mediated cytotoxicity (GO:0001910)3.14529507
133positive regulation of mast cell activation (GO:0033005)3.14291555
134regulation of isotype switching to IgG isotypes (GO:0048302)3.12880737
135regulation of granulocyte differentiation (GO:0030852)3.12704129
136myeloid cell activation involved in immune response (GO:0002275)3.11043084
137mitotic sister chromatid cohesion (GO:0007064)3.10336717
138meiotic cell cycle process (GO:1903046)3.09121817
139nucleus organization (GO:0006997)3.07657775
140dendritic cell migration (GO:0036336)3.07344393
141amino-acid betaine transport (GO:0015838)3.06135064
142carnitine transport (GO:0015879)3.06135064
143protein refolding (GO:0042026)3.04324231
144positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.03602988
145immunoglobulin mediated immune response (GO:0016064)3.03507235
146interferon-gamma secretion (GO:0072643)3.02685901
147negative regulation of adaptive immune response (GO:0002820)3.01563289
148regulation of cell killing (GO:0031341)3.00996225
149positive regulation of macrophage activation (GO:0043032)3.00520798
150protein localization to cilium (GO:0061512)3.00427747
151nucleoside diphosphate phosphorylation (GO:0006165)2.99828963
152interferon-gamma-mediated signaling pathway (GO:0060333)2.98767931
153synapsis (GO:0007129)2.98709952
154glycolytic process (GO:0006096)2.96726221
155cellular extravasation (GO:0045123)2.96193727
156negative regulation of T-helper cell differentiation (GO:0045623)2.96094450
157negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.96094450
158positive regulation of translational initiation (GO:0045948)2.94555875
159response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.94002011
160response to host immune response (GO:0052572)2.94002011
161carnitine transmembrane transport (GO:1902603)2.91780682
162polyol catabolic process (GO:0046174)2.89953980
163positive regulation of mast cell degranulation (GO:0043306)2.89566025
164positive regulation of mast cell activation involved in immune response (GO:0033008)2.89566025
165regulation of necroptotic process (GO:0060544)2.88749765
166mast cell activation (GO:0045576)2.87461738
167alditol metabolic process (GO:0019400)2.85513434
168positive regulation of isotype switching (GO:0045830)2.80879160
169respiratory burst (GO:0045730)2.79073265
170GTP biosynthetic process (GO:0006183)2.78772468
171regulation of interferon-beta biosynthetic process (GO:0045357)2.78428777
172polyamine biosynthetic process (GO:0006596)2.78331493
173regulation of interleukin-2 biosynthetic process (GO:0045076)2.77329804
174cilium organization (GO:0044782)2.72700168
175microtubule-based movement (GO:0007018)2.64734611
176RNA localization (GO:0006403)2.64207305
177cellular component assembly involved in morphogenesis (GO:0010927)2.63692771
178chromatin silencing (GO:0006342)2.61394966
179intraciliary transport (GO:0042073)2.60938852
180RNA destabilization (GO:0050779)2.60773692
181cilium assembly (GO:0042384)2.60583798
182cilium morphogenesis (GO:0060271)2.60363053
183protein localization to chromosome, centromeric region (GO:0071459)2.55727336
184gene silencing by RNA (GO:0031047)2.55559469
185negative regulation of organelle assembly (GO:1902116)2.54932435
186regulation of cilium assembly (GO:1902017)2.54432392
187axoneme assembly (GO:0035082)2.50867457
188histone exchange (GO:0043486)2.49994439
189lactate metabolic process (GO:0006089)2.49792064
190UTP biosynthetic process (GO:0006228)2.47417488
191sperm motility (GO:0030317)13.5972002
192cell wall macromolecule catabolic process (GO:0016998)13.2815931
193cell wall macromolecule metabolic process (GO:0044036)13.2815931
194fusion of sperm to egg plasma membrane (GO:0007342)13.0354464
195acrosome assembly (GO:0001675)12.1621685
196acrosome reaction (GO:0007340)11.8332817
197sperm-egg recognition (GO:0035036)11.6989242
198multicellular organism reproduction (GO:0032504)11.0052792
199binding of sperm to zona pellucida (GO:0007339)10.6756234
200cell-cell recognition (GO:0009988)10.4707254

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.52769006
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.09961745
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.99648942
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.71582838
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.50334907
6RUNX_20019798_ChIP-Seq_JUKART_Human3.97400031
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.83493139
8EZH2_22144423_ChIP-Seq_EOC_Human3.77638400
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.70607674
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.38872667
11MYB_26560356_Chip-Seq_TH2_Human3.29052646
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.19770398
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.17403057
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.03477552
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.97260791
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.94705208
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.88795965
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.87775510
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.68376959
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.64160165
21MYB_26560356_Chip-Seq_TH1_Human2.62656712
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.61283373
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53236291
24MAF_26560356_Chip-Seq_TH1_Human2.50193028
25SCL_19346495_ChIP-Seq_HPC-7_Human2.48561877
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.34743753
27SPI1_23127762_ChIP-Seq_K562_Human2.32606717
28VDR_22108803_ChIP-Seq_LS180_Human2.31612779
29UTX_26944678_Chip-Seq_JUKART_Human2.30998590
30CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.29887016
31STAT4_19710469_ChIP-ChIP_TH1__Mouse2.29184618
32SMAD_19615063_ChIP-ChIP_OVARY_Human2.28487214
33* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.28377938
34SPI1_23547873_ChIP-Seq_NB4_Human2.28021195
35GATA1_26923725_Chip-Seq_HPCs_Mouse2.27562677
36GATA3_27048872_Chip-Seq_THYMUS_Human2.23165670
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.21749084
38FLI1_27457419_Chip-Seq_LIVER_Mouse2.19800835
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.14045715
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.04268352
41EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.00804670
42KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.97213013
43ZNF274_21170338_ChIP-Seq_K562_Hela1.95361694
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94076107
45VDR_24763502_ChIP-Seq_THP-1_Human1.93297380
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92660907
47GATA3_26560356_Chip-Seq_TH2_Human1.91543986
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.90893846
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89512507
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85940931
51MYC_22102868_ChIP-Seq_BL_Human1.84868324
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.81923815
53VDR_24787735_ChIP-Seq_THP-1_Human1.79894158
54KAP1_22055183_ChIP-Seq_ESCs_Mouse1.79607750
55MAF_26560356_Chip-Seq_TH2_Human1.79132986
56FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78306290
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77588952
58STAT1_17558387_ChIP-Seq_HELA_Human1.77388560
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74693089
60TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.74685276
61GATA1_22025678_ChIP-Seq_K562_Human1.74280239
62ELK4_26923725_Chip-Seq_MESODERM_Mouse1.70213021
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.69061233
64GATA3_21867929_ChIP-Seq_CD8_Mouse1.63647097
65RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.63587349
66SOX2_22085726_ChIP-Seq_NPCs_Mouse1.63423658
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60982406
68MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.59667444
69VDR_21846776_ChIP-Seq_THP-1_Human1.58773328
70GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.58319835
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50155369
72* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46952760
73KDM2B_26808549_Chip-Seq_REH_Human1.45071572
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.43554450
75TAL1_26923725_Chip-Seq_HPCs_Mouse1.43496902
76FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.42078241
77WDR5_24793694_ChIP-Seq_LNCAP_Human1.41891048
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40931042
79GATA3_21867929_ChIP-Seq_TH1_Mouse1.38491232
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37242963
81CBP_20019798_ChIP-Seq_JUKART_Human1.37242963
82GATA1_19941827_ChIP-Seq_MEL_Mouse1.35582300
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.34935004
84LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.34870149
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33317879
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33094154
87P53_21459846_ChIP-Seq_SAOS-2_Human1.32838428
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31395412
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31013665
90SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.30594004
91Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30230321
92* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.27649676
93TCF7_22412390_ChIP-Seq_EML_Mouse1.27220507
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.26709522
95GF1_26923725_Chip-Seq_HPCs_Mouse1.25061266
96CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24237971
97CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23352099
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22845832
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22778581
100RUNX1_26923725_Chip-Seq_HPCs_Mouse1.22611927
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22006300
102SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20060952
103PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19734905
104REST_21632747_ChIP-Seq_MESCs_Mouse1.19678264
105SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.19225196
106SPI1_26923725_Chip-Seq_HPCs_Mouse1.19224116
107GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19046522
108CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19008397
109PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18466255
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18185998
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17840291
112RAD21_21589869_ChIP-Seq_MESCs_Mouse1.14176111
113GATA1_19941826_ChIP-Seq_K562_Human1.13877461
114ERG_20517297_ChIP-Seq_VCAP_Human1.13009901
115NANOG_18555785_Chip-Seq_ESCs_Mouse1.12592537
116CRX_20693478_ChIP-Seq_RETINA_Mouse1.12567892
117VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11355579
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10664519
119KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09718270
120GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09394143
121SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09288463
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09030134
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09030134
124ESET_19884257_ChIP-Seq_ESCs_Mouse1.08767749
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07891266
126CIITA_25753668_ChIP-Seq_RAJI_Human1.07540082
127CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07297031
128RARA_24833708_ChIP-Seq_LIVER_Mouse1.07129917
129RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07078587
130NOTCH1_21737748_ChIP-Seq_TLL_Human1.07005264
131* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06853609
132RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06041644
133KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05528303
134OCT4_18555785_Chip-Seq_ESCs_Mouse1.05086943
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04850119
136CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04581396
137GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04472640
138KDM2B_26808549_Chip-Seq_DND41_Human1.03889953
139RNF2_27304074_Chip-Seq_NSC_Mouse1.03055702
140TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02873643
141GATA1_19941827_ChIP-Seq_MEL86_Mouse1.01884354
142LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01603015
143ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01105545
144PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00855496
145CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99677621
146EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99071324
147MYC_27129775_Chip-Seq_CORNEA_Mouse0.98991557
148P53_22387025_ChIP-Seq_ESCs_Mouse0.98679905
149TET1_21451524_ChIP-Seq_MESCs_Mouse0.98033083
150YY1_22570637_ChIP-Seq_MALME-3M_Human0.97602762
151KLF4_18555785_Chip-Seq_ESCs_Mouse0.96940812
152EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96207068
153GATA2_19941826_ChIP-Seq_K562_Human0.96139144
154RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95992012
155CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95979300
156* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95750260
157FLI1_21867929_ChIP-Seq_CD8_Mouse0.95654989
158PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95414580
159CMYC_18555785_Chip-Seq_ESCs_Mouse0.95141530
160NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93864003
161OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93709068
162SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93680745
163ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93671648
164RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93139223
165MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92943348
166ESRRB_18555785_Chip-Seq_ESCs_Mouse0.92763409
167SOX11_22085726_ChIP-Seq_ESNs_Mouse0.92704823
168PU_27001747_Chip-Seq_BMDM_Mouse0.92564532
169P300_18555785_Chip-Seq_ESCs_Mouse0.92359267
170EZH2_27294783_Chip-Seq_NPCs_Mouse0.89851166
171SMRT_27268052_Chip-Seq_Bcells_Human0.89556518
172GF1B_26923725_Chip-Seq_HPCs_Mouse0.89174685
173* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.88085050
174ELF1_20517297_ChIP-Seq_JURKAT_Human0.87803273
175TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87610989
176NANOG_20526341_ChIP-Seq_ESCs_Human0.86972971
177CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.86646742
178* GATA3_26560356_Chip-Seq_TH1_Human0.84790989
179BCL6_27268052_Chip-Seq_Bcells_Human0.84704034
180TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84398285
181CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79774210
182* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78755398
183FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76061993
184RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73952807
185KDM2B_26808549_Chip-Seq_JURKAT_Human0.73477722
186PU.1_20513432_ChIP-Seq_Bcells_Mouse0.71941485
187P300_27268052_Chip-Seq_Bcells_Human0.71381649
188CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.71226084
189SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.70315562
190RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.69848362
191GATA1_22383799_ChIP-Seq_G1ME_Mouse0.68618333
192IKZF1_21737484_ChIP-ChIP_HCT116_Human0.67719301

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.04601453
2MP0001929_abnormal_gametogenesis5.66006916
3MP0008877_abnormal_DNA_methylation4.31590756
4MP0001835_abnormal_antigen_presentation4.01895599
5MP0005671_abnormal_response_to3.95228142
6MP0003763_abnormal_thymus_physiology3.81817826
7MP0003436_decreased_susceptibility_to3.81815661
8MP0002210_abnormal_sex_determination3.50177450
9MP0002161_abnormal_fertility/fecundity3.36766567
10MP0001800_abnormal_humoral_immune3.35728187
11MP0003724_increased_susceptibility_to3.24223204
12MP0005000_abnormal_immune_tolerance3.15904895
13MP0001145_abnormal_male_reproductive2.97748324
14MP0002723_abnormal_immune_serum2.87089664
15MP0006082_CNS_inflammation2.84863352
16MP0000685_abnormal_immune_system2.83002739
17MP0005670_abnormal_white_adipose2.76989792
18MP0005387_immune_system_phenotype2.76775053
19MP0001790_abnormal_immune_system2.76775053
20MP0002420_abnormal_adaptive_immunity2.75675222
21MP0005025_abnormal_response_to2.73529002
22MP0001819_abnormal_immune_cell2.72911792
23MP0002419_abnormal_innate_immunity2.67824425
24MP0000653_abnormal_sex_gland2.64855404
25MP0009785_altered_susceptibility_to2.62427640
26MP0002452_abnormal_antigen_presenting2.60661664
27MP0002653_abnormal_ependyma_morphology2.56100091
28MP0009333_abnormal_splenocyte_physiolog2.44850923
29MP0002148_abnormal_hypersensitivity_rea2.43427575
30MP0003303_peritoneal_inflammation2.38790515
31MP0002398_abnormal_bone_marrow2.32732612
32MP0002405_respiratory_system_inflammati2.29027478
33MP0000716_abnormal_immune_system2.20018969
34MP0003866_abnormal_defecation2.14729643
35MP0005464_abnormal_platelet_physiology2.09637381
36MP0000703_abnormal_thymus_morphology2.05840814
37MP0003646_muscle_fatigue2.04335872
38MP0005410_abnormal_fertilization16.2137867
39MP0000689_abnormal_spleen_morphology1.97438026
40MP0002722_abnormal_immune_system1.96408391
41MP0002396_abnormal_hematopoietic_system1.94168540
42MP0010155_abnormal_intestine_physiology1.92599440
43MP0003300_gastrointestinal_ulcer1.85741320
44MP0001845_abnormal_inflammatory_respons1.80872262
45MP0005075_abnormal_melanosome_morpholog1.76466407
46MP0001873_stomach_inflammation1.75273243
47MP0001533_abnormal_skeleton_physiology1.72029814
48MP0002429_abnormal_blood_cell1.69499343
49MP0004381_abnormal_hair_follicle1.66908171
50MP0008260_abnormal_autophagy1.66496153
51MP0004947_skin_inflammation1.63957614
52MP0005310_abnormal_salivary_gland1.61034817
53MP0002160_abnormal_reproductive_system1.59183031
54MP0002166_altered_tumor_susceptibility1.45818460
55MP0003172_abnormal_lysosome_physiology1.45596202
56MP0009764_decreased_sensitivity_to1.41644609
57MP0004233_abnormal_muscle_weight1.39258025
58MP0005623_abnormal_meninges_morphology1.28983674
59MP0001851_eye_inflammation1.26323551
60MP0008058_abnormal_DNA_repair1.25581303
61MP0008469_abnormal_protein_level1.23642198
62MP0000465_gastrointestinal_hemorrhage1.21895696
63MP0001986_abnormal_taste_sensitivity1.14605456
64MP0004883_abnormal_blood_vessel1.14349459
65MP0000858_altered_metastatic_potential1.12270721
66MP0002282_abnormal_trachea_morphology1.09109954
67MP0001765_abnormal_ion_homeostasis1.07606377
68MP0002277_abnormal_respiratory_mucosa1.05599502
69MP0003828_pulmonary_edema1.04253517
70MP0002254_reproductive_system_inflammat1.00678649
71MP0004130_abnormal_muscle_cell1.00398906
72MP0002998_abnormal_bone_remodeling0.95831082
73MP0002006_tumorigenesis0.94476415
74MP0005647_abnormal_sex_gland0.92914182
75MP0005166_decreased_susceptibility_to0.92178358
76MP0010094_abnormal_chromosome_stability0.89654835
77MP0001984_abnormal_olfaction0.89224880
78MP0002933_joint_inflammation0.88438568
79MP0005389_reproductive_system_phenotype0.86919875
80MP0003191_abnormal_cellular_cholesterol0.86578999
81MP0009046_muscle_twitch0.83690358
82MP0001663_abnormal_digestive_system0.83063497
83MP0002138_abnormal_hepatobiliary_system0.82021894
84MP0009763_increased_sensitivity_to0.81581313
85MP0000015_abnormal_ear_pigmentation0.80915928
86MP0002234_abnormal_pharynx_morphology0.80721116
87MP0003656_abnormal_erythrocyte_physiolo0.78058593
88MP0000372_irregular_coat_pigmentation0.77964152
89MP0003448_altered_tumor_morphology0.77642135
90MP0001853_heart_inflammation0.77232179
91MP0001348_abnormal_lacrimal_gland0.76411791
92MP0003111_abnormal_nucleus_morphology0.75179103
93MP0003690_abnormal_glial_cell0.71041794
94MP0003699_abnormal_female_reproductive0.70253028
95MP0002019_abnormal_tumor_incidence0.68883882
96MP0008995_early_reproductive_senescence0.66543027
97MP0003045_fibrosis0.65999595
98MP0001919_abnormal_reproductive_system0.64838682
99MP0002009_preneoplasia0.64718163
100MP0004036_abnormal_muscle_relaxation0.63826327
101MP0005636_abnormal_mineral_homeostasis0.63396591
102MP0005174_abnormal_tail_pigmentation0.62818271
103MP0003011_delayed_dark_adaptation0.61175018
104MP0008873_increased_physiological_sensi0.58436606
105MP0003115_abnormal_respiratory_system0.58106448
106MP0003075_altered_response_to0.58087765
107MP0009765_abnormal_xenobiotic_induced0.57792406
108MP0002102_abnormal_ear_morphology0.57716469
109MP0004484_altered_response_of0.57603288
110MP0001545_abnormal_hematopoietic_system0.57105074
111MP0005397_hematopoietic_system_phenotyp0.57105074
112MP0005164_abnormal_response_to0.56017326
113MP0000490_abnormal_crypts_of0.54349019
114MP0005390_skeleton_phenotype0.53449319
115MP0003878_abnormal_ear_physiology0.53297631
116MP0005377_hearing/vestibular/ear_phenot0.53297631
117MP0002693_abnormal_pancreas_physiology0.52417624
118MP0006036_abnormal_mitochondrial_physio0.51807352
119MP0005666_abnormal_adipose_tissue0.51286881
120MP0000358_abnormal_cell_content/0.51019036
121MP0000249_abnormal_blood_vessel0.50194728
122MP0008057_abnormal_DNA_replication0.50097003
123MP0003329_amyloid_beta_deposits0.50042122
124MP0001119_abnormal_female_reproductive0.49997844
125MP0008961_abnormal_basal_metabolism0.49935828
126MP0002332_abnormal_exercise_endurance0.49729950
127MP0002269_muscular_atrophy0.47446280
128MP0001730_embryonic_growth_arrest0.45010813
129MP0008007_abnormal_cellular_replicative0.44706438
130MP0003950_abnormal_plasma_membrane0.44642904
131MP0005451_abnormal_body_composition0.44315910
132MP0001764_abnormal_homeostasis0.44210906
133MP0003718_maternal_effect0.44003064
134MP0003786_premature_aging0.43885991
135MP0001324_abnormal_eye_pigmentation0.43572553
136MP0003077_abnormal_cell_cycle0.40230892
137MP0001293_anophthalmia0.40185778
138MP0009278_abnormal_bone_marrow0.39391395
139MP0000534_abnormal_ureter_morphology0.37006465
140MP0005253_abnormal_eye_physiology0.35720616
141MP0002736_abnormal_nociception_after0.33096393
142MP0009115_abnormal_fat_cell0.32913718
143MP0004019_abnormal_vitamin_homeostasis0.31519250
144MP0010307_abnormal_tumor_latency0.31295252
145MP0003879_abnormal_hair_cell0.30936690
146MP0000569_abnormal_digit_pigmentation0.30770206
147MP0002928_abnormal_bile_duct0.30452284
148MP0005551_abnormal_eye_electrophysiolog0.30213754
149MP0005391_vision/eye_phenotype0.30068073
150MP0004145_abnormal_muscle_electrophysio0.28635425
151MP0004084_abnormal_cardiac_muscle0.28111041
152MP0006035_abnormal_mitochondrial_morpho0.27923191
153MP0002169_no_abnormal_phenotype0.25796869
154MP0004133_heterotaxia0.25762280
155MP0003787_abnormal_imprinting0.25663721
156MP0002873_normal_phenotype0.25496481
157MP0002971_abnormal_brown_adipose0.25071659
158MP0000462_abnormal_digestive_system0.25008876
159MP0003861_abnormal_nervous_system0.24896299
160MP0002084_abnormal_developmental_patter0.23891466
161MP0000313_abnormal_cell_death0.23720972
162MP0001849_ear_inflammation0.22738039
163MP0001672_abnormal_embryogenesis/_devel0.22433296
164MP0005380_embryogenesis_phenotype0.22433296
165MP0003693_abnormal_embryo_hatching0.21492267
166MP0001697_abnormal_embryo_size0.21011416
167MP0000604_amyloidosis0.20962950
168MP0003942_abnormal_urinary_system0.19235927
169MP0005395_other_phenotype0.18749425
170MP0004957_abnormal_blastocyst_morpholog0.18729914
171MP0004811_abnormal_neuron_physiology0.18558159
172MP0001661_extended_life_span0.18519794
173MP0004808_abnormal_hematopoietic_stem0.18068621
174MP0002152_abnormal_brain_morphology0.17980135
175MP0002092_abnormal_eye_morphology0.17390647
176MP0000001_mammalian_phenotype0.17239109
177MP0002139_abnormal_hepatobiliary_system0.16884833
178MP0002132_abnormal_respiratory_system0.16757979
179MP0003633_abnormal_nervous_system0.16657268
180MP0002085_abnormal_embryonic_tissue0.16233182
181MP0003631_nervous_system_phenotype0.15931992
182MP0002080_prenatal_lethality0.15552343
183MP0002295_abnormal_pulmonary_circulatio0.15342178
184MP0003984_embryonic_growth_retardation0.14787259
185MP0003948_abnormal_gas_homeostasis0.13852973

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.50398275
2Abnormal respiratory epithelium morphology (HP:0012253)9.03474539
3Abnormal respiratory motile cilium morphology (HP:0005938)9.03474539
4Rhinitis (HP:0012384)7.58504207
5Chronic bronchitis (HP:0004469)7.57770833
6Abnormal ciliary motility (HP:0012262)7.50858193
7Infertility (HP:0000789)7.03500383
8Nasal polyposis (HP:0100582)6.30892392
9T lymphocytopenia (HP:0005403)5.54436759
10Elevated erythrocyte sedimentation rate (HP:0003565)5.43866297
11Male infertility (HP:0003251)5.29632516
12Abnormality of the nasal mucosa (HP:0000433)5.16305931
13Myositis (HP:0100614)5.12966126
14Abnormality of T cell number (HP:0011839)5.07191260
15Stomatitis (HP:0010280)4.95387429
16Recurrent abscess formation (HP:0002722)4.80263991
17Gastrointestinal infarctions (HP:0005244)4.74804470
18Retrobulbar optic neuritis (HP:0100654)4.74604133
19Optic neuritis (HP:0100653)4.74604133
20Bronchitis (HP:0012387)4.61953248
21Recurrent bacterial skin infections (HP:0005406)4.50515227
22Orchitis (HP:0100796)4.49075408
23Eczematoid dermatitis (HP:0000976)4.46901164
24Abnormal delayed hypersensitivity skin test (HP:0002963)4.46110213
25Bronchiectasis (HP:0002110)4.45348195
26Recurrent cutaneous fungal infections (HP:0011370)4.26821013
27Chronic mucocutaneous candidiasis (HP:0002728)4.26821013
28Recurrent fungal infections (HP:0002841)4.20782306
29Nephronophthisis (HP:0000090)4.17266668
30Meningitis (HP:0001287)4.00209094
31Panhypogammaglobulinemia (HP:0003139)3.97592471
32Abnormality of T cells (HP:0002843)3.90672513
33Autoimmune hemolytic anemia (HP:0001890)3.90664144
34Abnormal spermatogenesis (HP:0008669)3.88576971
35Mediastinal lymphadenopathy (HP:0100721)3.87648512
36Encephalitis (HP:0002383)3.78522136
37IgG deficiency (HP:0004315)3.74047655
38Keratoconjunctivitis (HP:0001096)3.59617458
39Recurrent skin infections (HP:0001581)3.53490954
40Abnormality of macrophages (HP:0004311)3.51617237
41Abnormality of B cell number (HP:0010975)3.49072113
42B lymphocytopenia (HP:0010976)3.47141145
43Obstructive lung disease (HP:0006536)3.39273343
44Chronic obstructive pulmonary disease (HP:0006510)3.39273343
45Recurrent sinusitis (HP:0011108)3.38830091
46Recurrent otitis media (HP:0000403)3.33063043
47Vasculitis (HP:0002633)3.31463173
48Recurrent viral infections (HP:0004429)3.28710257
49Keratoconjunctivitis sicca (HP:0001097)3.27201877
50Leukocytosis (HP:0001974)3.26089541
51Prolonged bleeding time (HP:0003010)3.24129767
52Pustule (HP:0200039)3.21889712
53Pulmonary infiltrates (HP:0002113)3.16396348
54Chest pain (HP:0100749)3.13053532
55Abnormality of the renal medulla (HP:0100957)3.11834220
56Hypochromic microcytic anemia (HP:0004840)3.11329745
57Inflammation of the large intestine (HP:0002037)3.01645718
58Hemoptysis (HP:0002105)3.01615987
59Spontaneous hematomas (HP:0007420)2.95673028
60Severe combined immunodeficiency (HP:0004430)2.88705971
61Colitis (HP:0002583)2.88606420
62Gastrointestinal inflammation (HP:0004386)2.81798329
63Recurrent gram-negative bacterial infections (HP:0005420)2.79301448
64Arterial thrombosis (HP:0004420)2.78309858
65Molar tooth sign on MRI (HP:0002419)2.76967151
66Abnormality of midbrain morphology (HP:0002418)2.76967151
67Epistaxis (HP:0000421)2.74141512
68Lymphopenia (HP:0001888)2.73773078
69Pulmonary embolism (HP:0002204)2.71599281
70Anorexia (HP:0002039)2.70264963
71Abnormality of T cell physiology (HP:0011840)2.69912187
72Abnormality of eosinophils (HP:0001879)2.69033659
73Granulocytopenia (HP:0001913)2.65837872
74Recurrent bronchitis (HP:0002837)2.64741524
75Impulsivity (HP:0100710)2.63710943
76Eosinophilia (HP:0001880)2.63028595
77Tubulointerstitial nephritis (HP:0001970)2.61246197
78Gingivitis (HP:0000230)2.59047436
79Agammaglobulinemia (HP:0004432)2.58908329
80IgM deficiency (HP:0002850)2.57868306
81Tubular atrophy (HP:0000092)2.56686723
82Gingival bleeding (HP:0000225)2.55040173
83Azoospermia (HP:0000027)2.53787281
84Abnormality of cells of the lymphoid lineage (HP:0012140)2.49266618
85Chronic diarrhea (HP:0002028)2.44935312
86Abnormality of the fingertips (HP:0001211)2.43938578
87Medial flaring of the eyebrow (HP:0010747)2.43304045
88Gangrene (HP:0100758)2.40768865
89Hypochromic anemia (HP:0001931)2.39892953
90Tubulointerstitial abnormality (HP:0001969)2.37742336
91Slow saccadic eye movements (HP:0000514)2.37246805
92Keratitis (HP:0000491)2.36771505
93Joint swelling (HP:0001386)2.35932782
94Hemiplegia (HP:0002301)2.35384265
95Hypoproteinemia (HP:0003075)2.29282322
96Thyroiditis (HP:0100646)2.27496290
97Cholecystitis (HP:0001082)2.27367956
98Abnormal gallbladder physiology (HP:0012438)2.27367956
99Acute hepatic failure (HP:0006554)2.26873812
100Abnormality of the pleura (HP:0002103)2.26212553
101Increased IgE level (HP:0003212)2.25610072
102Peritonitis (HP:0002586)2.24954528
103Abnormality of the prostate (HP:0008775)2.20959026
104Urticaria (HP:0001025)2.20764089
105Papilledema (HP:0001085)2.20449638
106Combined immunodeficiency (HP:0005387)2.17176354
107Episodic fever (HP:0001954)2.17158671
108Hypoplasia of the thymus (HP:0000778)2.17060714
109Gonadotropin excess (HP:0000837)2.16586021
110Increased IgM level (HP:0003496)2.15772240
111Glomerulopathy (HP:0100820)2.07819359
112Dyschromatopsia (HP:0007641)2.06415109
113Genetic anticipation (HP:0003743)2.02833541
114Microcytic anemia (HP:0001935)2.02339302
115Tubulointerstitial fibrosis (HP:0005576)2.02198556
116Alveolar cell carcinoma (HP:0006519)2.01764848
117Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.4730445
118Absent/shortened dynein arms (HP:0200106)13.1431413
119Dynein arm defect of respiratory motile cilia (HP:0012255)13.1431413
120Hematochezia (HP:0002573)1.99500899
121Glucose intolerance (HP:0000833)1.98248521
122Verrucae (HP:0200043)1.98011118
123Papilloma (HP:0012740)1.98011118
124Neoplasm of the tracheobronchial system (HP:0100552)1.94682739
125Decreased central vision (HP:0007663)1.91328588
126Vertigo (HP:0002321)1.90485754
127Autoimmune thrombocytopenia (HP:0001973)1.90312946
128Osteomyelitis (HP:0002754)1.90061360
129Diplopia (HP:0000651)1.88321322
130Abnormality of binocular vision (HP:0011514)1.88321322
131Postaxial foot polydactyly (HP:0001830)1.85191526
132Polyneuropathy (HP:0001271)1.82814506
133Viral hepatitis (HP:0006562)1.81942948
134Facial diplegia (HP:0001349)1.81175573
135Abnormal drinking behavior (HP:0030082)1.81000688
136Polydipsia (HP:0001959)1.81000688
137Sepsis (HP:0100806)1.80860969
138Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80710191
139Choroideremia (HP:0001139)1.78125165
140Congenital hepatic fibrosis (HP:0002612)1.75336426
141Spastic tetraparesis (HP:0001285)1.72824826
142Stage 5 chronic kidney disease (HP:0003774)1.71553303
143Abnormality of the renal cortex (HP:0011035)1.67985046
144Double outlet right ventricle (HP:0001719)1.66989091
145Congenital malformation of the right heart (HP:0011723)1.66989091
146Pancreatic fibrosis (HP:0100732)1.65515331
147Abnormality of renal excretion (HP:0011036)1.65188954
148Bile duct proliferation (HP:0001408)1.60560531
149Abnormal biliary tract physiology (HP:0012439)1.60560531
150Short ribs (HP:0000773)1.58605831
151Abnormality of the dental root (HP:0006486)1.54870151
152Taurodontia (HP:0000679)1.54870151
153Abnormality of permanent molar morphology (HP:0011071)1.54870151
154Oculomotor apraxia (HP:0000657)1.53898685
155Bundle branch block (HP:0011710)1.53250551
156Heterotopia (HP:0002282)1.53196061
157Fibular hypoplasia (HP:0003038)1.52175224
158Hemorrhage of the eye (HP:0011885)1.52017551
159Facial cleft (HP:0002006)1.51632620
160Asymmetric septal hypertrophy (HP:0001670)1.46260682
161Cystic liver disease (HP:0006706)1.45751083
162Renal dysplasia (HP:0000110)1.44693974
163Microglossia (HP:0000171)1.43665618
164Aplasia/Hypoplasia of the lens (HP:0008063)1.43342235
165Abnormality of the dental pulp (HP:0006479)1.43162061
166Abnormality of molar (HP:0011077)1.43148209
167Abnormality of molar morphology (HP:0011070)1.43148209
168Postaxial hand polydactyly (HP:0001162)1.42371321
169Absent epiphyses (HP:0010577)1.40978671
170Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.40978671
171Decreased electroretinogram (ERG) amplitude (HP:0000654)1.39735526
172Abnormal urine output (HP:0012590)1.35808075
173Abnormality of dentin (HP:0010299)1.34820209
174Bell-shaped thorax (HP:0001591)1.34579224
175Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.34090644
176Abnormality of the lower motor neuron (HP:0002366)1.33114045
177Aplasia/Hypoplasia of the tongue (HP:0010295)1.32918791
178Deformed sella turcica (HP:0002681)1.30562736
179Neurofibrillary tangles (HP:0002185)1.28378418
180Chronic sinusitis (HP:0011109)1.27956754
181Exercise-induced myalgia (HP:0003738)1.27168202
182Easy fatigability (HP:0003388)1.25937948
183Constricted visual fields (HP:0001133)1.25121979
184Absent frontal sinuses (HP:0002688)1.24111930
185Congenital primary aphakia (HP:0007707)1.22753171
186Amyotrophic lateral sclerosis (HP:0007354)1.22367981
187Gait imbalance (HP:0002141)1.21371373
188Median cleft lip (HP:0000161)1.21153353
189Abnormality of saccadic eye movements (HP:0000570)1.20028079
190True hermaphroditism (HP:0010459)1.19403034
191Short nail (HP:0001799)1.18824237
192Supernumerary spleens (HP:0009799)1.17787829
193J-shaped sella turcica (HP:0002680)1.17678826
194Fatigable weakness (HP:0003473)1.16893060
195Abnormality of the neuromuscular junction (HP:0003398)1.16893060
196Cerebellar dysplasia (HP:0007033)1.15844652
197Nephropathy (HP:0000112)1.15748528
198Broad distal phalanx of finger (HP:0009836)1.15513827
199Polyuria (HP:0000103)1.15174160

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.26484684
2PDK38.26484684
3TESK16.07774153
4PDK25.32820377
5MAP4K15.00478228
6PRKD34.89172317
7GRK64.24019955
8ICK4.14285158
9RIPK13.77296684
10TXK3.19629425
11JAK32.62042187
12BLK2.41758065
13BTK2.38611362
14FES2.38111178
15ITK2.33753426
16PTK2B2.25201673
17TAOK32.24543533
18BCKDK2.23113449
19MAP3K132.19997962
20CSK2.15320626
21WNK42.07310981
22SYK2.05881870
23STK392.00742196
24STK381.99697219
25TEC1.97255792
26NEK21.91288642
27TYK21.90618534
28LCK1.72783360
29PNCK1.61398265
30TNK21.60204586
31IKBKE1.57848270
32JAK11.51309744
33KIT1.48646499
34LYN1.45647515
35IRAK41.44110882
36MAP4K21.43655757
37HCK1.42172260
38DYRK1B1.38017215
39PDK11.21576137
40MAP2K31.17010460
41FGR1.13758440
42PINK11.11570891
43MATK1.09487414
44IKBKB1.06194448
45PIK3CG1.05478702
46FRK1.04805790
47DYRK30.99355685
48TTK0.95305407
49STK38L0.94406706
50KSR20.89631937
51MAP3K140.88902350
52TBK10.88367162
53MAP3K30.87799975
54MAP3K10.87327595
55JAK20.87077983
56TYRO30.86263669
57STK30.84043716
58MAP3K20.83452686
59FGFR30.83014235
60EEF2K0.80814941
61SIK30.80645399
62FYN0.79480789
63CCNB10.78466141
64PDPK10.76643517
65PLK40.74724103
66MAP3K110.72901204
67ERN10.72311613
68CHEK20.72205424
69HIPK20.70539782
70CAMKK20.68461674
71GRK70.67593618
72WNK10.67288356
73FGFR40.67067035
74IRAK10.66899231
75SGK30.66551974
76MUSK0.65508080
77MAPK150.64129583
78ACVR1B0.62812503
79TESK20.62405272
80PASK0.61836900
81WEE10.61812238
82EPHB10.61803589
83PRPF4B0.60637770
84NLK0.58877924
85STK40.58141168
86RIPK40.57637013
87PRKCI0.56195180
88MAPK110.55491464
89NUAK10.55062649
90MAP3K90.53391504
91YES10.52965244
92LMTK20.49951434
93SGK20.47372570
94MAP2K60.44172154
95CHEK10.42782185
96BRSK20.42189656
97SIK20.41990664
98PAK10.41862920
99KDR0.40844548
100TGFBR20.39563596
101RAF10.39108209
102CDC42BPA0.38869380
103IGF1R0.36609436
104IRAK20.36531644
105PIK3CA0.36444287
106MAP3K70.36067102
107PRKCH0.34855864
108PLK10.34128680
109RET0.33845316
110KSR10.33117664
111MAPK70.32858605
112NTRK20.32689784
113PRKCG0.31502241
114BUB10.31484684
115BRAF0.31349349
116CDC70.31165576
117EGFR0.30251739
118PTK60.29927660
119ATM0.29628076
120ERBB20.28878257
121ATR0.28660192
122MAP3K100.28329926
123MAPKAPK50.28038281
124CLK10.27914861
125CAMK40.27764803
126BRSK10.25645941
127PRKAA10.24906540
128CAMK1G0.24883647
129LATS10.24320228
130STK100.23080079
131MARK20.22896679
132PAK20.19279727
133MTOR0.18769493
134PAK40.16239967
135NEK60.16153469
136PRKCZ0.13930248
137CAMKK10.13594211
138CDK150.13195033
139AURKA0.12447484
140RPS6KB10.11889515
141LATS20.11872420
142CDK180.10208484
143CSNK2A10.10057183
144PRKCQ0.09733318
145CDK11A0.09061231
146MAP3K40.09014876
147RPS6KA10.07259213
148PAK60.07185752
149PRKG20.07024930
150BMPR20.06703126
151CDK20.06555602
152MAP3K50.06329134
153MAP2K70.06230481
154CDK10.06179493
155TAOK10.05627423
156GSK3B0.05424082
157CDK140.04929991
158CDK40.04660210
159PIM10.04489854
160MARK30.03918088
161CSNK2A20.03174044
162MOS0.02819384
163AURKB0.02741139
164ZAP700.02359389
165CSF1R0.02086489
166CAMK2A0.01858089
167PRKG10.01552539
168STK110.01312730
169MAPK80.00830109
170PRKACG0.00071886
171MAP3K6-0.0271582
172DYRK2-0.0194440
173PRKCA-0.0194396
174PRKCD-0.0038145
175CDK3-0.0031742
176CSNK1D-0.0003640

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.54674670
2Fatty acid biosynthesis_Homo sapiens_hsa000614.33465816
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.29405468
4Primary immunodeficiency_Homo sapiens_hsa053403.88751280
5Graft-versus-host disease_Homo sapiens_hsa053323.73231089
6Pyruvate metabolism_Homo sapiens_hsa006203.43747961
7Allograft rejection_Homo sapiens_hsa053303.27571771
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.25846578
9Linoleic acid metabolism_Homo sapiens_hsa005913.20538107
10Autoimmune thyroid disease_Homo sapiens_hsa053203.16967470
11Basal transcription factors_Homo sapiens_hsa030222.87933299
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.75995115
13T cell receptor signaling pathway_Homo sapiens_hsa046602.67570270
14Propanoate metabolism_Homo sapiens_hsa006402.67251067
15Glucagon signaling pathway_Homo sapiens_hsa049222.55071814
16Type I diabetes mellitus_Homo sapiens_hsa049402.44866166
17Leishmaniasis_Homo sapiens_hsa051402.38718607
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.30931755
19Hematopoietic cell lineage_Homo sapiens_hsa046402.29376043
20B cell receptor signaling pathway_Homo sapiens_hsa046622.24637330
21Pentose phosphate pathway_Homo sapiens_hsa000302.20908792
22Staphylococcus aureus infection_Homo sapiens_hsa051502.19995850
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.13093944
24Asthma_Homo sapiens_hsa053102.12819456
25Intestinal immune network for IgA production_Homo sapiens_hsa046722.07799267
26Carbohydrate digestion and absorption_Homo sapiens_hsa049732.05386829
27Measles_Homo sapiens_hsa051622.01706493
28Osteoclast differentiation_Homo sapiens_hsa043801.98546905
29Oocyte meiosis_Homo sapiens_hsa041141.97956332
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.97549728
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.94596167
32Glycerolipid metabolism_Homo sapiens_hsa005611.93199658
33Viral myocarditis_Homo sapiens_hsa054161.90264960
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.88308955
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.83766122
36Selenocompound metabolism_Homo sapiens_hsa004501.80779740
37Acute myeloid leukemia_Homo sapiens_hsa052211.77230547
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.76144125
39PPAR signaling pathway_Homo sapiens_hsa033201.69155288
40Fanconi anemia pathway_Homo sapiens_hsa034601.68395372
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.65530993
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.62145262
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.61532684
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.61047083
45Tuberculosis_Homo sapiens_hsa051521.59306719
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57096182
47Fructose and mannose metabolism_Homo sapiens_hsa000511.55224253
48Ether lipid metabolism_Homo sapiens_hsa005651.53847537
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.52939102
50Malaria_Homo sapiens_hsa051441.52769852
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.44414240
52Fat digestion and absorption_Homo sapiens_hsa049751.43780470
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.43517432
54Mineral absorption_Homo sapiens_hsa049781.43043263
55Jak-STAT signaling pathway_Homo sapiens_hsa046301.43028379
56Amphetamine addiction_Homo sapiens_hsa050311.39970025
57Carbon metabolism_Homo sapiens_hsa012001.39871223
58Chemokine signaling pathway_Homo sapiens_hsa040621.36016426
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33766399
60Influenza A_Homo sapiens_hsa051641.32277331
61Toxoplasmosis_Homo sapiens_hsa051451.29606745
62Purine metabolism_Homo sapiens_hsa002301.26800883
63Non-small cell lung cancer_Homo sapiens_hsa052231.26125504
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.25160519
65Herpes simplex infection_Homo sapiens_hsa051681.25064496
66Dorso-ventral axis formation_Homo sapiens_hsa043201.24728914
67RNA transport_Homo sapiens_hsa030131.22441245
68Fatty acid degradation_Homo sapiens_hsa000711.21396192
69Cardiac muscle contraction_Homo sapiens_hsa042601.21166961
70Fatty acid metabolism_Homo sapiens_hsa012121.20064657
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17009261
72Rheumatoid arthritis_Homo sapiens_hsa053231.12930690
73mRNA surveillance pathway_Homo sapiens_hsa030151.09700444
74Regulation of autophagy_Homo sapiens_hsa041401.08650521
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07947619
76Platelet activation_Homo sapiens_hsa046111.06859644
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05235144
78Biosynthesis of amino acids_Homo sapiens_hsa012301.05165667
79Huntingtons disease_Homo sapiens_hsa050161.02382228
80Glutathione metabolism_Homo sapiens_hsa004801.01971350
81TNF signaling pathway_Homo sapiens_hsa046681.01564261
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98759509
83African trypanosomiasis_Homo sapiens_hsa051430.89560277
84Renin secretion_Homo sapiens_hsa049240.89347962
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89222127
86Antigen processing and presentation_Homo sapiens_hsa046120.88016531
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87121252
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85598662
89Collecting duct acid secretion_Homo sapiens_hsa049660.84640868
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84572046
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.84484352
92Arachidonic acid metabolism_Homo sapiens_hsa005900.84310615
93Apoptosis_Homo sapiens_hsa042100.79412944
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78744367
95Renin-angiotensin system_Homo sapiens_hsa046140.77792603
96Hedgehog signaling pathway_Homo sapiens_hsa043400.76167973
97Hepatitis C_Homo sapiens_hsa051600.74339084
98Choline metabolism in cancer_Homo sapiens_hsa052310.74323396
99Hepatitis B_Homo sapiens_hsa051610.73569045
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72728933
101mTOR signaling pathway_Homo sapiens_hsa041500.69736882
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.68593261
103Chemical carcinogenesis_Homo sapiens_hsa052040.68478866
104Pyrimidine metabolism_Homo sapiens_hsa002400.66241383
105Phagosome_Homo sapiens_hsa041450.65415489
106Prolactin signaling pathway_Homo sapiens_hsa049170.62936632
107Insulin secretion_Homo sapiens_hsa049110.62714716
108Pancreatic cancer_Homo sapiens_hsa052120.62712825
109Systemic lupus erythematosus_Homo sapiens_hsa053220.62460939
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62406618
111HTLV-I infection_Homo sapiens_hsa051660.61300968
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.60717175
113Estrogen signaling pathway_Homo sapiens_hsa049150.60708994
114Long-term potentiation_Homo sapiens_hsa047200.59786237
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58747156
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.57829489
117ErbB signaling pathway_Homo sapiens_hsa040120.57524268
118Thyroid hormone synthesis_Homo sapiens_hsa049180.56612049
119Cell cycle_Homo sapiens_hsa041100.55690581
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54405678
121Bile secretion_Homo sapiens_hsa049760.52388549
122Thyroid cancer_Homo sapiens_hsa052160.51625828
123RNA degradation_Homo sapiens_hsa030180.51624252
124FoxO signaling pathway_Homo sapiens_hsa040680.50729218
125Pertussis_Homo sapiens_hsa051330.50090306
126Renal cell carcinoma_Homo sapiens_hsa052110.48753943
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.46757330
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.46210093
129Insulin resistance_Homo sapiens_hsa049310.46194234
130AMPK signaling pathway_Homo sapiens_hsa041520.46184420
131HIF-1 signaling pathway_Homo sapiens_hsa040660.46067410
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44480797
133Pancreatic secretion_Homo sapiens_hsa049720.44337985
134Chronic myeloid leukemia_Homo sapiens_hsa052200.43472025
135Metabolic pathways_Homo sapiens_hsa011000.42546840
136Colorectal cancer_Homo sapiens_hsa052100.42265159
137Shigellosis_Homo sapiens_hsa051310.42224780
138Endometrial cancer_Homo sapiens_hsa052130.40313924
139Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40161078
140Endocytosis_Homo sapiens_hsa041440.39657714
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39177091
142Inositol phosphate metabolism_Homo sapiens_hsa005620.38845417
143Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38751789
144Legionellosis_Homo sapiens_hsa051340.38305905
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.38300134
146DNA replication_Homo sapiens_hsa030300.38031289
147Calcium signaling pathway_Homo sapiens_hsa040200.37871045
148Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37604227
149Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36894994
150Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36095419
151Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35863694
152Salmonella infection_Homo sapiens_hsa051320.34861287
153Lysosome_Homo sapiens_hsa041420.34507216
154Protein digestion and absorption_Homo sapiens_hsa049740.33709092
155VEGF signaling pathway_Homo sapiens_hsa043700.33289907
156Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32550402
157Salivary secretion_Homo sapiens_hsa049700.31800063
158Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.31315183
159Olfactory transduction_Homo sapiens_hsa047400.31305931
160ABC transporters_Homo sapiens_hsa020100.30907756
161Notch signaling pathway_Homo sapiens_hsa043300.30588606
162Glioma_Homo sapiens_hsa052140.29666111
163AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.29393765
164Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28472864
165MAPK signaling pathway_Homo sapiens_hsa040100.28295126
166Synaptic vesicle cycle_Homo sapiens_hsa047210.26993779
167Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25955494
168Sulfur metabolism_Homo sapiens_hsa009200.24225270
169Alcoholism_Homo sapiens_hsa050340.23201797
170Type II diabetes mellitus_Homo sapiens_hsa049300.23117596
171Homologous recombination_Homo sapiens_hsa034400.22919680
172Rap1 signaling pathway_Homo sapiens_hsa040150.22857170
173Cholinergic synapse_Homo sapiens_hsa047250.21541441
174Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.21140160
175cAMP signaling pathway_Homo sapiens_hsa040240.20784716
176Gastric acid secretion_Homo sapiens_hsa049710.17814975
177Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17542244
178Viral carcinogenesis_Homo sapiens_hsa052030.14162463
179Taste transduction_Homo sapiens_hsa047420.13373907
180Base excision repair_Homo sapiens_hsa034100.13373034
181Epstein-Barr virus infection_Homo sapiens_hsa051690.12004039
182Proteasome_Homo sapiens_hsa030500.10632675
183Cocaine addiction_Homo sapiens_hsa050300.10064684

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