ARSA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.64787129
2negative regulation of cell killing (GO:0031342)4.64787129
3sperm motility (GO:0030317)4.55547229
4complement activation, alternative pathway (GO:0006957)4.51064769
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.44967877
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.44348764
7L-phenylalanine catabolic process (GO:0006559)4.44348764
8fusion of sperm to egg plasma membrane (GO:0007342)4.37624953
9alpha-linolenic acid metabolic process (GO:0036109)4.36760390
10antigen processing and presentation of endogenous antigen (GO:0019883)4.31233584
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.30253810
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.14719122
13L-phenylalanine metabolic process (GO:0006558)4.13399628
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.13399628
15regulation of protein activation cascade (GO:2000257)4.12849248
16fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.09397730
17regulation of complement activation (GO:0030449)4.06008847
18acrosome reaction (GO:0007340)4.05797691
19peptidyl-glutamic acid carboxylation (GO:0017187)4.02668671
20protein carboxylation (GO:0018214)4.02668671
21positive regulation of gamma-delta T cell activation (GO:0046645)3.95771960
22neutrophil activation involved in immune response (GO:0002283)3.93458855
23response to peptidoglycan (GO:0032494)3.87739188
24cilium or flagellum-dependent cell motility (GO:0001539)3.86067911
25positive regulation by symbiont of host defense response (GO:0052509)3.83039156
26modulation by symbiont of host defense response (GO:0052031)3.83039156
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.83039156
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.83039156
29positive regulation by organism of defense response of other organism involved in symbiotic interact3.83039156
30modulation by symbiont of host immune response (GO:0052553)3.83039156
31macrophage activation involved in immune response (GO:0002281)3.78716050
32triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.78184972
33negative regulation of fibrinolysis (GO:0051918)3.72275199
34detection of other organism (GO:0098543)3.69360048
35detection of bacterium (GO:0016045)3.69038095
36negative regulation of interleukin-12 production (GO:0032695)3.64763109
37immunoglobulin mediated immune response (GO:0016064)3.63207114
38aromatic amino acid family catabolic process (GO:0009074)3.55372306
39low-density lipoprotein particle clearance (GO:0034383)3.53988243
40plasma lipoprotein particle clearance (GO:0034381)3.53912629
41bile acid biosynthetic process (GO:0006699)3.52287158
42negative regulation of erythrocyte differentiation (GO:0045647)3.51094392
43regulation of fibrinolysis (GO:0051917)3.41827472
44plasma membrane fusion (GO:0045026)3.39961287
45sulfur amino acid catabolic process (GO:0000098)3.39774516
46regulation of triglyceride catabolic process (GO:0010896)3.37027348
47urea metabolic process (GO:0019627)3.35982330
48urea cycle (GO:0000050)3.35982330
49opsonization (GO:0008228)3.32177912
50cellular response to type I interferon (GO:0071357)3.30085211
51type I interferon signaling pathway (GO:0060337)3.30085211
52response to type I interferon (GO:0034340)3.29959997
53detection of external biotic stimulus (GO:0098581)3.29125207
54high-density lipoprotein particle remodeling (GO:0034375)3.23893739
55germinal center formation (GO:0002467)3.19689209
56acylglycerol homeostasis (GO:0055090)3.19315811
57triglyceride homeostasis (GO:0070328)3.19315811
58cell wall macromolecule metabolic process (GO:0044036)3.13892998
59cell wall macromolecule catabolic process (GO:0016998)3.13892998
60positive regulation of triglyceride lipase activity (GO:0061365)3.13399046
61positive regulation of lipoprotein lipase activity (GO:0051006)3.13399046
62regulation of interferon-beta biosynthetic process (GO:0045357)3.12911739
63fibrinolysis (GO:0042730)3.12558340
64acrosome assembly (GO:0001675)3.12062934
65NIK/NF-kappaB signaling (GO:0038061)3.11417145
66coenzyme catabolic process (GO:0009109)3.09872920
67regulation of dendritic cell antigen processing and presentation (GO:0002604)3.09014233
68response to muramyl dipeptide (GO:0032495)3.08156066
69regulation of mast cell degranulation (GO:0043304)3.07634043
70tyrosine metabolic process (GO:0006570)3.06649083
71regulation of cholesterol homeostasis (GO:2000188)3.05975266
72nitrogen cycle metabolic process (GO:0071941)3.05529712
73detection of molecule of bacterial origin (GO:0032490)3.04910075
74leukocyte aggregation (GO:0070486)3.03418212
75multicellular organism reproduction (GO:0032504)3.03241957
76amino-acid betaine metabolic process (GO:0006577)3.02943769
77complement activation (GO:0006956)3.01304135
78reverse cholesterol transport (GO:0043691)2.98051700
79positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.97138219
80regulation of gamma-delta T cell activation (GO:0046643)2.96972791
81interferon-gamma-mediated signaling pathway (GO:0060333)2.96904539
82* sperm-egg recognition (GO:0035036)2.96801273
83lipopolysaccharide-mediated signaling pathway (GO:0031663)2.94043341
84kynurenine metabolic process (GO:0070189)2.93842618
85complement activation, classical pathway (GO:0006958)2.93795296
86bile acid metabolic process (GO:0008206)2.92192210
87reproduction (GO:0000003)2.91553303
88organic cation transport (GO:0015695)2.90687875
89cellular extravasation (GO:0045123)2.90047978
90regulation of plasminogen activation (GO:0010755)2.89998806
91detection of biotic stimulus (GO:0009595)2.88800825
92positive regulation of lipid catabolic process (GO:0050996)2.87846482
93regulation of antigen processing and presentation (GO:0002577)2.87633322
94tryptophan catabolic process (GO:0006569)2.87278842
95indole-containing compound catabolic process (GO:0042436)2.87278842
96indolalkylamine catabolic process (GO:0046218)2.87278842
97negative regulation of cytokine production involved in immune response (GO:0002719)2.87119489
98phospholipid efflux (GO:0033700)2.86231592
99regulation of leukocyte degranulation (GO:0043300)2.85543674
100plasma lipoprotein particle remodeling (GO:0034369)2.85495707
101protein-lipid complex remodeling (GO:0034368)2.85495707
102macromolecular complex remodeling (GO:0034367)2.85495707
103regulation of T-helper 2 cell differentiation (GO:0045628)2.85470676
104glyoxylate metabolic process (GO:0046487)2.84669284
105negative regulation of lymphocyte mediated immunity (GO:0002707)2.83198923
106granulocyte activation (GO:0036230)2.83028483
107regulation of myeloid leukocyte mediated immunity (GO:0002886)2.82679825
108axonemal dynein complex assembly (GO:0070286)2.82662528
109neutrophil activation (GO:0042119)2.81407339
110positive regulation of antigen processing and presentation (GO:0002579)2.81240964
111protein activation cascade (GO:0072376)2.80528505
112defense response to protozoan (GO:0042832)2.79095347
113negative regulation of protein activation cascade (GO:2000258)2.78676890
114macrophage activation (GO:0042116)2.76666866
115regulation of fatty acid beta-oxidation (GO:0031998)2.75898985
116negative regulation of leukocyte mediated immunity (GO:0002704)2.75607057
117regulation of mast cell activation involved in immune response (GO:0033006)2.75248537
118cofactor catabolic process (GO:0051187)2.75182628
119positive regulation of triglyceride metabolic process (GO:0090208)2.74925425
120epithelial cilium movement (GO:0003351)2.74872391
121negative regulation of innate immune response (GO:0045824)2.73734956
122positive regulation of fatty acid beta-oxidation (GO:0032000)2.72556320
123carnitine metabolic process (GO:0009437)2.71586667
124regulation of T cell tolerance induction (GO:0002664)2.71480060
125cysteine metabolic process (GO:0006534)2.71447977
126mannose metabolic process (GO:0006013)2.70716329
127cholesterol efflux (GO:0033344)2.70511259
128tryptophan metabolic process (GO:0006568)2.70296595
129myeloid dendritic cell differentiation (GO:0043011)2.69851799
130* cell-cell recognition (GO:0009988)2.69461439
131positive regulation of fatty acid oxidation (GO:0046321)2.69392049
132epoxygenase P450 pathway (GO:0019373)2.67880103
133myeloid cell activation involved in immune response (GO:0002275)2.66536731
134spermatid development (GO:0007286)2.65376699
135regulation of B cell receptor signaling pathway (GO:0050855)2.64436078
136regulation of cholesterol esterification (GO:0010872)2.64262115
137response to protozoan (GO:0001562)2.62600552
138homocysteine metabolic process (GO:0050667)2.61520444
139amino sugar catabolic process (GO:0046348)2.60749260
140negative regulation of sterol transport (GO:0032372)2.59725729
141negative regulation of cholesterol transport (GO:0032375)2.59725729
142positive thymic T cell selection (GO:0045059)2.59623485
143regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.58751945
144negative regulation of interleukin-6 production (GO:0032715)2.58162125
145positive regulation of fatty acid biosynthetic process (GO:0045723)2.58146610
146cholesterol homeostasis (GO:0042632)2.56499158
147macroautophagy (GO:0016236)2.55535856
148regulation of cholesterol storage (GO:0010885)2.54936061
149lipoprotein metabolic process (GO:0042157)2.54900670
150* binding of sperm to zona pellucida (GO:0007339)2.54634846
151fatty acid catabolic process (GO:0009062)2.54560802
152tolerance induction (GO:0002507)2.54265863
153positive regulation of glycolytic process (GO:0045821)2.54144325
154regulation of gamma-delta T cell differentiation (GO:0045586)2.53733017
1554-hydroxyproline metabolic process (GO:0019471)2.53560809
156T-helper 1 type immune response (GO:0042088)2.53289607
157regulation of tolerance induction (GO:0002643)2.53133262
158response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.52694792
159response to host immune response (GO:0052572)2.52694792
160sterol homeostasis (GO:0055092)2.52633905
161respiratory burst (GO:0045730)2.52193205
162fatty-acyl-CoA biosynthetic process (GO:0046949)2.52177474
163cellular modified amino acid catabolic process (GO:0042219)2.51994891
164fatty acid beta-oxidation (GO:0006635)2.51238319
165B cell mediated immunity (GO:0019724)2.51193306
166peptidyl-glutamic acid modification (GO:0018200)2.50834431
167positive regulation of coagulation (GO:0050820)2.50736396
168sexual reproduction (GO:0019953)2.50643013
169positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.50588978
170regulation of lipid catabolic process (GO:0050994)2.50405463
171positive regulation of blood coagulation (GO:0030194)2.50368356
172regulation of T-helper 1 cell differentiation (GO:0045625)2.48570686
173regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.48506999
174myeloid dendritic cell activation (GO:0001773)2.46474565
175microglial cell activation (GO:0001774)2.46281183
176positive regulation of type 2 immune response (GO:0002830)2.44139262
177regulation of chemokine biosynthetic process (GO:0045073)2.43662551
178regulation of type 2 immune response (GO:0002828)2.43038988
179regulation of T cell mediated cytotoxicity (GO:0001914)2.42573057
180barbed-end actin filament capping (GO:0051016)2.40921810
181positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.38695774
182virion attachment to host cell (GO:0019062)2.38121757
183adhesion of symbiont to host cell (GO:0044650)2.38121757
184positive regulation of mast cell activation (GO:0033005)2.37845109
185negative regulation of T cell mediated immunity (GO:0002710)2.37742252
186regulation of type I interferon-mediated signaling pathway (GO:0060338)2.37184733
187response to host (GO:0075136)2.35854797
188response to host defenses (GO:0052200)2.35854797
189response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.35854797
190regulation of mast cell activation (GO:0033003)2.35782976
191regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.35509939
192negative regulation of interleukin-8 production (GO:0032717)2.35384755
193regulation of interferon-alpha production (GO:0032647)2.34711805
194antigen processing and presentation via MHC class Ib (GO:0002475)2.34548355
195regulation of regulated secretory pathway (GO:1903305)2.34515322
196positive regulation of cellular amide metabolic process (GO:0034250)2.32714491
197positive regulation of mast cell degranulation (GO:0043306)2.31781291
198positive regulation of mast cell activation involved in immune response (GO:0033008)2.31781291
199negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.31534190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.73940169
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.21071170
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.19210109
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.61320385
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.55980580
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.30791608
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.82264291
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.79327660
9VDR_21846776_ChIP-Seq_THP-1_Human2.77419309
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.70792279
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.54008696
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.45505472
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35705089
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.34550362
15VDR_24763502_ChIP-Seq_THP-1_Human2.29757903
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.23846116
17* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.15840468
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.10641881
19E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.99569887
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.96218129
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.89467551
22KDM2B_26808549_Chip-Seq_DND41_Human1.86771807
23* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.85636826
24MAF_26560356_Chip-Seq_TH1_Human1.82618049
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.81012437
26RUNX1_22412390_ChIP-Seq_EML_Mouse1.80567280
27TCF7_22412390_ChIP-Seq_EML_Mouse1.79955370
28SPI1_23127762_ChIP-Seq_K562_Human1.78224624
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73645313
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.72302739
31UTX_26944678_Chip-Seq_JUKART_Human1.71595166
32CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.68236862
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.67222492
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67112998
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.67081108
36MYC_22102868_ChIP-Seq_BL_Human1.67046297
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66462668
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57515830
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54213137
40RACK7_27058665_Chip-Seq_MCF-7_Human1.54158958
41SPI1_23547873_ChIP-Seq_NB4_Human1.52237040
42MAF_26560356_Chip-Seq_TH2_Human1.51974628
43BCL6_27268052_Chip-Seq_Bcells_Human1.51902851
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48588710
45SCL_19346495_ChIP-Seq_HPC-7_Human1.48368985
46LXR_22292898_ChIP-Seq_THP-1_Human1.48144561
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.45619260
48RUNX_20019798_ChIP-Seq_JUKART_Human1.45321789
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45091368
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.42998906
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40782662
52CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39059680
53* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.37418983
54SA1_27219007_Chip-Seq_ERYTHROID_Human1.37383032
55CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35113301
56* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34925614
57* CLOCK_20551151_ChIP-Seq_293T_Human1.34727491
58STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34066651
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32734649
60P68_20966046_ChIP-Seq_HELA_Human1.32368176
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30535825
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30505302
63KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28647846
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25631532
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24380999
66FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22437219
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21800490
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21630967
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19273585
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18894303
71* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18035241
72SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16693138
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16493642
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.16350834
75EGR1_19374776_ChIP-ChIP_THP-1_Human1.16141051
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15679912
77* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15309362
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14370051
79* MYB_26560356_Chip-Seq_TH2_Human1.13717686
80* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12973248
81* KDM2B_26808549_Chip-Seq_JURKAT_Human1.12817220
82PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11899822
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10981251
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10659279
85TP63_17297297_ChIP-ChIP_HaCaT_Human1.10627825
86MYB_26560356_Chip-Seq_TH1_Human1.10099175
87GATA2_21666600_ChIP-Seq_HMVEC_Human1.09249387
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08838347
89CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08264465
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06890063
91* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.06405462
92FOXA2_19822575_ChIP-Seq_HepG2_Human1.06342879
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05924377
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05902418
95NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05733156
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05733156
97SA1_27219007_Chip-Seq_Bcells_Human1.03563805
98SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03546812
99NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99353631
100TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98036745
101CJUN_26792858_Chip-Seq_BT549_Human0.97830310
102ELF1_20517297_ChIP-Seq_JURKAT_Human0.97677271
103RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97272533
104* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97183156
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96763450
106DROSHA_22980978_ChIP-Seq_HELA_Human0.95214482
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93686035
108EZH2_22144423_ChIP-Seq_EOC_Human0.93122028
109PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92035553
110TBX20_22080862_ChIP-Seq_HEART_Mouse0.90289915
111TBX20_22328084_ChIP-Seq_HEART_Mouse0.90289915
112* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90134636
113IRF8_27001747_Chip-Seq_BMDM_Mouse0.89414619
114JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89027643
115SMC3_22415368_ChIP-Seq_MEFs_Mouse0.88374434
116EP300_21415370_ChIP-Seq_HL-1_Mouse0.88282775
117* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86111353
118PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.84624937
119RXRA_24833708_ChIP-Seq_LIVER_Mouse0.84116572
120NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83214476
121TP63_22573176_ChIP-Seq_HFKS_Human0.81966660
122ELK3_25401928_ChIP-Seq_HUVEC_Human0.81625788
123TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81281905
124CTCF_27219007_Chip-Seq_Bcells_Human0.81200986
125ZNF263_19887448_ChIP-Seq_K562_Human0.80656792
126MTF2_20144788_ChIP-Seq_MESCs_Mouse0.80585453
127BCOR_27268052_Chip-Seq_Bcells_Human0.80107080
128GATA1_19941826_ChIP-Seq_K562_Human0.79528458
129KLF4_19829295_ChIP-Seq_ESCs_Human0.78922327
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78778580
131LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.77911728
132P53_21459846_ChIP-Seq_SAOS-2_Human0.77830966
133* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.77411904
134SMC4_20622854_ChIP-Seq_HELA_Human0.77335391
135* TET1_21451524_ChIP-Seq_MESCs_Mouse0.77248550
136CDX2_19796622_ChIP-Seq_MESCs_Mouse0.77247481
137EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.76312934
138PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75706084
139P63_26484246_Chip-Seq_KERATINOCYTES_Human0.75533719
140CTCF_20526341_ChIP-Seq_ESCs_Human0.74951959
141IKZF1_21737484_ChIP-ChIP_HCT116_Human0.74692791
142FOXO3_23340844_ChIP-Seq_DLD1_Human0.74395186
143EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.74252489
144SUZ12_27294783_Chip-Seq_ESCs_Mouse0.74109000
145SMC1_22415368_ChIP-Seq_MEFs_Mouse0.73992516
146BCAT_22108803_ChIP-Seq_LS180_Human0.73295483
147SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.73243012
148PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73163099
149GATA2_19941826_ChIP-Seq_K562_Human0.72970242
150PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72944133
151STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.71658677
152ELK4_26923725_Chip-Seq_MESODERM_Mouse0.71463586
153SOX9_24532713_ChIP-Seq_HFSC_Mouse0.71299361
154KDM2B_26808549_Chip-Seq_SUP-B15_Human0.71272094
155* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.71204626
156* TET1_21490601_ChIP-Seq_MESCs_Mouse0.70231069
157PPAR_26484153_Chip-Seq_NCI-H1993_Human0.69798672
158VDR_24787735_ChIP-Seq_THP-1_Human0.69622507
159SOX2_27498859_Chip-Seq_STOMACH_Mouse0.69074712
160KDM2B_26808549_Chip-Seq_K562_Human0.68404379

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.01385001
2MP0008438_abnormal_cutaneous_collagen4.68681337
3MP0002139_abnormal_hepatobiliary_system4.67243317
4MP0005360_urolithiasis4.08087101
5MP0005365_abnormal_bile_salt3.51849101
6MP0005085_abnormal_gallbladder_physiolo3.49484202
7MP0001835_abnormal_antigen_presentation2.93318316
8MP0003252_abnormal_bile_duct2.86951988
9MP0005275_abnormal_skin_tensile2.77530889
10MP0008875_abnormal_xenobiotic_pharmacok2.75103659
11MP0003705_abnormal_hypodermis_morpholog2.71876891
12MP0002419_abnormal_innate_immunity2.67612829
13MP0009840_abnormal_foam_cell2.60100930
14MP0005025_abnormal_response_to2.57497627
15MP0009785_altered_susceptibility_to2.54897885
16MP0010329_abnormal_lipoprotein_level2.53288148
17MP0005000_abnormal_immune_tolerance2.50201923
18MP0005503_abnormal_tendon_morphology2.49614628
19MP0001790_abnormal_immune_system2.45238330
20MP0005387_immune_system_phenotype2.45238330
21MP0002148_abnormal_hypersensitivity_rea2.43733520
22MP0000685_abnormal_immune_system2.34492236
23MP0005671_abnormal_response_to2.34390029
24MP0003191_abnormal_cellular_cholesterol2.27891702
25MP0001800_abnormal_humoral_immune2.17715307
26MP0005058_abnormal_lysosome_morphology2.17360840
27MP0005670_abnormal_white_adipose2.10746591
28MP0002723_abnormal_immune_serum2.08327296
29MP0002452_abnormal_antigen_presenting2.02438014
30MP0003806_abnormal_nucleotide_metabolis1.95791277
31MP0002420_abnormal_adaptive_immunity1.91586271
32MP0001819_abnormal_immune_cell1.90962598
33MP0004510_myositis1.88948473
34MP0010155_abnormal_intestine_physiology1.88491913
35MP0003279_aneurysm1.83452811
36MP0000013_abnormal_adipose_tissue1.79622137
37MP0009278_abnormal_bone_marrow1.74156180
38MP0005451_abnormal_body_composition1.72974754
39* MP0002118_abnormal_lipid_homeostasis1.72709492
40MP0005083_abnormal_biliary_tract1.72329854
41MP0003195_calcinosis1.69349567
42MP0001845_abnormal_inflammatory_respons1.66872044
43MP0002405_respiratory_system_inflammati1.65301732
44MP0008260_abnormal_autophagy1.62582294
45MP0000609_abnormal_liver_physiology1.55875812
46MP0005623_abnormal_meninges_morphology1.55608223
47MP0003724_increased_susceptibility_to1.54395749
48MP0006054_spinal_hemorrhage1.53241413
49MP0002295_abnormal_pulmonary_circulatio1.53041653
50MP0009333_abnormal_splenocyte_physiolog1.52359784
51MP0010368_abnormal_lymphatic_system1.52049666
52MP0003172_abnormal_lysosome_physiology1.51444053
53MP0004272_abnormal_basement_membrane1.49688948
54MP0000858_altered_metastatic_potential1.43937990
55MP0003763_abnormal_thymus_physiology1.43288564
56MP0000604_amyloidosis1.41698428
57MP0005332_abnormal_amino_acid1.41650744
58MP0003329_amyloid_beta_deposits1.39832150
59MP0003690_abnormal_glial_cell1.38236572
60MP0000343_altered_response_to1.37774520
61* MP0000716_abnormal_immune_system1.36685914
62MP0009384_cardiac_valve_regurgitation1.35271749
63MP0003183_abnormal_peptide_metabolism1.31730261
64MP0000465_gastrointestinal_hemorrhage1.30856329
65MP0005397_hematopoietic_system_phenotyp1.29617596
66MP0001545_abnormal_hematopoietic_system1.29617596
67MP0001958_emphysema1.28940402
68MP0003075_altered_response_to1.28201955
69MP0004130_abnormal_muscle_cell1.24214523
70MP0005166_decreased_susceptibility_to1.23677942
71MP0002060_abnormal_skin_morphology1.22244328
72MP0002398_abnormal_bone_marrow1.21837302
73MP0005319_abnormal_enzyme/_coenzyme1.19887095
74MP0003828_pulmonary_edema1.17768176
75MP0005310_abnormal_salivary_gland1.14270073
76MP0005584_abnormal_enzyme/coenzyme_acti1.13913678
77MP0003866_abnormal_defecation1.13351654
78MP0001533_abnormal_skeleton_physiology1.12394187
79MP0001666_abnormal_nutrient_absorption1.09483680
80MP0001873_stomach_inflammation1.07000678
81MP0001851_eye_inflammation1.06276170
82MP0008004_abnormal_stomach_pH1.05190826
83MP0003448_altered_tumor_morphology1.04717185
84* MP0002429_abnormal_blood_cell1.04561287
85MP0003698_abnormal_male_reproductive1.04180498
86MP0000689_abnormal_spleen_morphology1.02067998
87MP0001663_abnormal_digestive_system1.01806616
88MP0002722_abnormal_immune_system1.00337726
89MP0002877_abnormal_melanocyte_morpholog0.99733712
90MP0000003_abnormal_adipose_tissue0.98278586
91MP0006082_CNS_inflammation0.96215244
92MP0003436_decreased_susceptibility_to0.94907290
93MP0003453_abnormal_keratinocyte_physiol0.94581973
94MP0001853_heart_inflammation0.94379180
95MP0002132_abnormal_respiratory_system0.94002390
96MP0002933_joint_inflammation0.92960210
97MP0005375_adipose_tissue_phenotype0.90729323
98MP0003300_gastrointestinal_ulcer0.89882266
99MP0004883_abnormal_blood_vessel0.89423895
100MP0005464_abnormal_platelet_physiology0.88872995
101MP0002971_abnormal_brown_adipose0.88655926
102MP0003868_abnormal_feces_composition0.88227788
103MP0005334_abnormal_fat_pad0.88019537
104MP0002896_abnormal_bone_mineralization0.87007059
105MP0009643_abnormal_urine_homeostasis0.86742619
106MP0001849_ear_inflammation0.86358878
107MP0004858_abnormal_nervous_system0.86339262
108MP0004019_abnormal_vitamin_homeostasis0.85899476
109MP0000598_abnormal_liver_morphology0.85679891
110MP0002090_abnormal_vision0.85344900
111MP0000249_abnormal_blood_vessel0.84690648
112MP0005167_abnormal_blood-brain_barrier0.84331621
113MP0005164_abnormal_response_to0.83556380
114MP0009780_abnormal_chondrocyte_physiolo0.83500447
115MP0003795_abnormal_bone_structure0.82110589
116MP0005666_abnormal_adipose_tissue0.81071109
117MP0002138_abnormal_hepatobiliary_system0.78997261
118MP0005535_abnormal_body_temperature0.77536370
119MP0008874_decreased_physiological_sensi0.77443358
120MP0005023_abnormal_wound_healing0.77291493
121MP0002796_impaired_skin_barrier0.76847518
122MP0003566_abnormal_cell_adhesion0.76658515
123* MP0000920_abnormal_myelination0.76045534
124MP0003656_abnormal_erythrocyte_physiolo0.74722669
125MP0002998_abnormal_bone_remodeling0.74452111
126MP0008469_abnormal_protein_level0.72168580
127MP0005595_abnormal_vascular_smooth0.71995398
128MP0002078_abnormal_glucose_homeostasis0.71172195
129MP0003045_fibrosis0.70907119
130MP0003633_abnormal_nervous_system0.70870769
131MP0005508_abnormal_skeleton_morphology0.70615802
132MP0002909_abnormal_adrenal_gland0.69809745
133MP0005390_skeleton_phenotype0.69678061
134MP0002254_reproductive_system_inflammat0.69324811
135MP0005165_increased_susceptibility_to0.68896377
136MP0008961_abnormal_basal_metabolism0.68711428
137MP0009115_abnormal_fat_cell0.68709370
138MP0001929_abnormal_gametogenesis0.68334299
139MP0001764_abnormal_homeostasis0.67839859
140MP0005381_digestive/alimentary_phenotyp0.67285166
141MP0001542_abnormal_bone_strength0.67274394
142MP0004947_skin_inflammation0.67071638
143MP0003091_abnormal_cell_migration0.66902218
144MP0003303_peritoneal_inflammation0.66257878
145MP0000703_abnormal_thymus_morphology0.65905611
146MP0001879_abnormal_lymphatic_vessel0.65904439
147MP0004381_abnormal_hair_follicle0.65841584
148MP0009763_increased_sensitivity_to0.65168250
149MP0005257_abnormal_intraocular_pressure0.65002206
150MP0009642_abnormal_blood_homeostasis0.64190092
151MP0010386_abnormal_urinary_bladder0.64089926
152MP0001243_abnormal_dermal_layer0.63960158
153MP0009764_decreased_sensitivity_to0.63795597
154MP0005448_abnormal_energy_balance0.63469450
155MP0000767_abnormal_smooth_muscle0.62845895

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)4.89876083
2Deep venous thrombosis (HP:0002625)4.85264260
3Eczematoid dermatitis (HP:0000976)4.71690751
4Abnormality of glycolipid metabolism (HP:0010969)4.60982167
5Abnormality of liposaccharide metabolism (HP:0010968)4.60982167
6Abnormality of glycosphingolipid metabolism (HP:0004343)4.60982167
7Abnormality of macrophages (HP:0004311)4.33453739
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.20599397
9Myositis (HP:0100614)4.19976724
10Xanthomatosis (HP:0000991)4.18789916
11Protrusio acetabuli (HP:0003179)4.15268619
12Recurrent abscess formation (HP:0002722)4.02147948
13Systemic lupus erythematosus (HP:0002725)3.96765239
14Abnormality of complement system (HP:0005339)3.90735350
15Recurrent bacterial skin infections (HP:0005406)3.85428617
16Orchitis (HP:0100796)3.80747312
17Absent/shortened dynein arms (HP:0200106)3.75800149
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.75800149
19Abnormality of aromatic amino acid family metabolism (HP:0004338)3.73735148
20Intrahepatic cholestasis (HP:0001406)3.72149399
21Prolonged partial thromboplastin time (HP:0003645)3.69332164
22Elevated erythrocyte sedimentation rate (HP:0003565)3.59264238
23Premature rupture of membranes (HP:0001788)3.41349862
24Stomatitis (HP:0010280)3.39361539
25Optic neuritis (HP:0100653)3.32178533
26Retrobulbar optic neuritis (HP:0100654)3.32178533
27Hyperlipoproteinemia (HP:0010980)3.31042578
28Mediastinal lymphadenopathy (HP:0100721)3.23293728
29Obstructive lung disease (HP:0006536)3.21339729
30Chronic obstructive pulmonary disease (HP:0006510)3.21339729
31Nasal polyposis (HP:0100582)3.15377546
32Abnormality of the nasal mucosa (HP:0000433)3.11945860
33Peritonitis (HP:0002586)3.10864114
34Abnormality of monocarboxylic acid metabolism (HP:0010996)3.10506455
35Neurofibrillary tangles (HP:0002185)3.09350277
36Purpura (HP:0000979)3.00075489
37Abnormality of the common coagulation pathway (HP:0010990)2.87326156
38Increased IgE level (HP:0003212)2.86245540
39Amyloidosis (HP:0011034)2.84023837
40Abnormal respiratory motile cilium physiology (HP:0012261)2.75658857
41Spontaneous hematomas (HP:0007420)2.75644794
42Meningitis (HP:0001287)2.75261250
43Abnormality of the intrinsic pathway (HP:0010989)2.72557704
44Gingivitis (HP:0000230)2.71159709
45Glomerulonephritis (HP:0000099)2.70139375
46Petechiae (HP:0000967)2.69922499
47Recurrent fungal infections (HP:0002841)2.69748471
48Skin nodule (HP:0200036)2.69609469
49Cerebral inclusion bodies (HP:0100314)2.69004997
50Hypercholesterolemia (HP:0003124)2.63834654
51Cervical subluxation (HP:0003308)2.63769532
52Epidermoid cyst (HP:0200040)2.61367369
53Dysostosis multiplex (HP:0000943)2.60844703
54Vasculitis (HP:0002633)2.60689285
55Gastrointestinal infarctions (HP:0005244)2.60169783
56Pulmonary infiltrates (HP:0002113)2.59156224
57Urinary glycosaminoglycan excretion (HP:0003541)2.57962588
58Mucopolysacchariduria (HP:0008155)2.57962588
59Abnormality of dentin (HP:0010299)2.55901237
60Recurrent skin infections (HP:0001581)2.54750373
61Hypobetalipoproteinemia (HP:0003563)2.54315383
62Broad metatarsal (HP:0001783)2.53277592
63Nonimmune hydrops fetalis (HP:0001790)2.52882420
64Hypoalphalipoproteinemia (HP:0003233)2.52107932
65Rhinitis (HP:0012384)2.50785862
66Joint hemorrhage (HP:0005261)2.48516844
67Beaking of vertebral bodies (HP:0004568)2.47208634
68Cellulitis (HP:0100658)2.45854407
69Vertebral compression fractures (HP:0002953)2.44791387
70Myocardial infarction (HP:0001658)2.44219317
71Ketosis (HP:0001946)2.44110814
72Mitral stenosis (HP:0001718)2.42840638
73Cerebral aneurysm (HP:0004944)2.42495143
74Prolonged bleeding time (HP:0003010)2.41329042
75Chronic bronchitis (HP:0004469)2.38417536
76Pustule (HP:0200039)2.36296741
77Abnormal delayed hypersensitivity skin test (HP:0002963)2.34862033
78Vacuolated lymphocytes (HP:0001922)2.34852882
79Abnormality of mucopolysaccharide metabolism (HP:0011020)2.34171134
80Abnormality of polysaccharide metabolism (HP:0011012)2.34171134
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.34171134
82Hypolipoproteinemia (HP:0010981)2.33225221
83Hemoptysis (HP:0002105)2.32739167
84Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.30486979
85Hypoglycemic coma (HP:0001325)2.30428073
86Hemorrhage of the eye (HP:0011885)2.30367500
87Keratoconjunctivitis sicca (HP:0001097)2.28683162
88Abnormal respiratory motile cilium morphology (HP:0005938)2.28033507
89Abnormal respiratory epithelium morphology (HP:0012253)2.28033507
90Epistaxis (HP:0000421)2.27619978
91Increased serum ferritin (HP:0003281)2.27382514
92Malnutrition (HP:0004395)2.26541754
93Recurrent gram-negative bacterial infections (HP:0005420)2.25050183
94Infertility (HP:0000789)2.24938326
95Urticaria (HP:0001025)2.24677290
96Hand muscle atrophy (HP:0009130)2.24168703
97Increased cerebral lipofuscin (HP:0011813)2.23745075
98Upper limb amyotrophy (HP:0009129)2.23576587
99Distal upper limb amyotrophy (HP:0007149)2.23576587
100Encephalitis (HP:0002383)2.23400793
101Abnormality of glutamine family amino acid metabolism (HP:0010902)2.20367817
102Inflammation of the large intestine (HP:0002037)2.19306611
103Axonal loss (HP:0003447)2.19102870
104Emphysema (HP:0002097)2.18688641
105Hypergammaglobulinemia (HP:0010702)2.18659855
106Gastrointestinal inflammation (HP:0004386)2.17927909
107Hepatosplenomegaly (HP:0001433)2.17231540
108Protuberant abdomen (HP:0001538)2.15973433
109Interstitial pulmonary disease (HP:0006530)2.15648736
110Gingival bleeding (HP:0000225)2.14565484
111Supranuclear gaze palsy (HP:0000605)2.13107043
112Colitis (HP:0002583)2.12743042
113Joint stiffness (HP:0001387)2.10655064
114Progressive neurologic deterioration (HP:0002344)2.08244547
115Chronic mucocutaneous candidiasis (HP:0002728)2.08240162
116Recurrent cutaneous fungal infections (HP:0011370)2.08240162
117Chest pain (HP:0100749)2.08130005
118Gastrointestinal stroma tumor (HP:0100723)2.08028867
119Keratoconjunctivitis (HP:0001096)2.07169389
120Fat malabsorption (HP:0002630)2.07085748
121Nuclear cataract (HP:0100018)2.06908433
122Global brain atrophy (HP:0002283)2.05020014
123Pulmonary embolism (HP:0002204)2.04830184
124Asymmetric septal hypertrophy (HP:0001670)2.01066735
125Episodic fever (HP:0001954)2.00645392
126Restrictive lung disease (HP:0002091)2.00087684
127Ankle contracture (HP:0006466)1.97969138
128Hyperammonemia (HP:0001987)1.97939877
129J-shaped sella turcica (HP:0002680)1.97679738
130Autoimmune thrombocytopenia (HP:0001973)1.97573488
131Premature loss of primary teeth (HP:0006323)1.97533653
132Increased IgM level (HP:0003496)1.93243782
133Nephritis (HP:0000123)1.93167040
134Recurrent viral infections (HP:0004429)1.92889202
135Increased neuronal autofluorescent lipopigment (HP:0002074)1.92652547
136Polycythemia (HP:0001901)1.91879074
137Abnormality of the lower motor neuron (HP:0002366)1.91406744
138Acne (HP:0001061)1.91108853
139Cardiovascular calcification (HP:0011915)1.90738126
140Ovoid vertebral bodies (HP:0003300)1.90195174
141Disinhibition (HP:0000734)1.89789622
142Tetraparesis (HP:0002273)1.89183440
143Abnormality of iron homeostasis (HP:0011031)1.87530129
144Retinal atrophy (HP:0001105)1.87111976
145Polygenic inheritance (HP:0010982)1.86305938
146Spondylolisthesis (HP:0003302)1.86146484
147Mutism (HP:0002300)1.85697496
148Prolonged neonatal jaundice (HP:0006579)1.84049059
149Abnormal ciliary motility (HP:0012262)1.84036128
150Thin bony cortex (HP:0002753)1.83721844
151Hematochezia (HP:0002573)1.83447212
152Leukocytosis (HP:0001974)1.82466135
153* Abnormal gallbladder physiology (HP:0012438)1.80047757
154* Cholecystitis (HP:0001082)1.80047757
155Ketoacidosis (HP:0001993)1.78524517
156Biconcave vertebral bodies (HP:0004586)1.78282838
157Hypoglycemic seizures (HP:0002173)1.76101590
158* Loss of speech (HP:0002371)1.75483333
159Hyperinsulinemic hypoglycemia (HP:0000825)1.74903102
160Vascular calcification (HP:0004934)1.73900855
161Ectopia lentis (HP:0001083)1.73715465
162Shallow orbits (HP:0000586)1.72969535
163Aortic dissection (HP:0002647)1.72797015
164Turricephaly (HP:0000262)1.70950546
165Short nail (HP:0001799)1.70863202
166Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.70568576
167Neuronal loss in central nervous system (HP:0002529)1.70473335
168Buphthalmos (HP:0000557)1.70078344
169Increased variability in muscle fiber diameter (HP:0003557)1.67478776
170Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.66454969
171Spontaneous abortion (HP:0005268)1.65000200
172Bladder diverticulum (HP:0000015)1.64995853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.17542352
2PDK33.57207977
3PDK43.57207977
4TRIB33.34454213
5MAP4K13.18577049
6TESK13.09636912
7PRKD33.04650495
8PDK22.88088724
9ICK2.37187200
10PRPF4B2.35908740
11PTK2B2.16528741
12MAP3K112.15865075
13MAPK151.94438440
14EPHB11.93062718
15ZAP701.92748100
16SIK11.90636549
17IRAK41.87786472
18GRK61.87265560
19TAOK11.78396223
20PKN21.75940925
21MST1R1.75096556
22TIE11.69801834
23IRAK31.67006712
24NTRK11.64388692
25FES1.64225953
26JAK31.59535685
27FGFR41.59474336
28KDR1.58468697
29TAOK21.55538262
30BCKDK1.52654132
31INSRR1.48923369
32MAP3K131.48877114
33DDR21.47920686
34TGFBR21.46111644
35PTK61.45910361
36IKBKE1.43909799
37CDC42BPA1.43281422
38MET1.43109243
39RIPK11.40818886
40TXK1.39676484
41BMX1.38228571
42TESK21.30996115
43CAMKK11.28670874
44BTK1.24416610
45PDGFRA1.22999970
46TBK11.22752506
47IKBKB1.22232073
48SYK1.12353018
49DYRK1B1.10056053
50SIK31.09988583
51MATK1.09226529
52WNK41.07847882
53MAP3K61.07563623
54GRK71.07156326
55NME21.05343411
56RET1.05158265
57ARAF1.01367924
58PTK21.00908418
59FGR0.98475324
60CAMK1G0.97986391
61EPHA30.96566093
62LYN0.95929130
63JAK10.93055810
64MAP2K60.91439845
65SMG10.90687290
66LCK0.90666087
67MAPK70.90644119
68SIK20.87480199
69KIT0.85529025
70PRKCH0.84862960
71FLT30.84467114
72STK390.83934340
73STK380.82118755
74MAP3K30.79068736
75KSR20.77379276
76PAK20.76944521
77PIM20.76911728
78TTN0.76522847
79MAP3K10.76490294
80MAPKAPK50.76355318
81TAOK30.76337901
82PAK60.75949287
83LATS20.75008579
84ITK0.71695816
85PDPK10.71040597
86MARK30.67964325
87HIPK20.67250022
88MAP2K40.67214267
89PDK10.67195723
90IRAK20.66676563
91TYK20.66525193
92BMPR20.66178357
93WNK10.65926399
94FGFR20.65485143
95IRAK10.63574815
96RPS6KC10.63498778
97RPS6KL10.63498778
98FER0.63401653
99JAK20.60272249
100PIK3CG0.60151806
101CSK0.59221937
102RIPK40.58971109
103ABL20.58322188
104MAP3K20.55081405
105CSF1R0.53794699
106PAK30.52458200
107RPS6KA60.51606467
108CAMK1D0.51509848
109PRKD10.50542906
110DAPK20.50451865
111MAP2K30.50347566
112FYN0.49630417
113MAP2K20.49408901
114MAP3K70.48312147
115MAP2K10.47319442
116PRKG20.46883491
117CHUK0.46462419
118PDGFRB0.45248063
119CAMKK20.44856560
120TRPM70.44853157
121TYRO30.44430682
122MAPK120.44173844
123MARK20.43864559
124MOS0.42519749
125NEK90.41892109
126PAK40.41890549
127MAPK40.41570341
128BLK0.41176887
129MAP3K90.40583536
130DAPK30.40280192
131LRRK20.39988109
132GRK50.39812568
133SRC0.38944457
134PRKD20.38074897
135TNK20.37329918
136MAP3K50.36883861
137RPS6KA20.36854757
138IGF1R0.36742758
139MAPKAPK20.36468908
140ERBB40.36311829
141MAP3K140.36199940
142GSK3A0.35972852
143MTOR0.35757452
144EEF2K0.35080940
145PRKCZ0.34298666
146HCK0.33806464

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.47118318
2Complement and coagulation cascades_Homo sapiens_hsa046102.84566332
3Nitrogen metabolism_Homo sapiens_hsa009102.74879449
4Osteoclast differentiation_Homo sapiens_hsa043802.59151423
5Leishmaniasis_Homo sapiens_hsa051402.45913037
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.32589580
7Fatty acid degradation_Homo sapiens_hsa000712.31657724
8Allograft rejection_Homo sapiens_hsa053302.31303708
9PPAR signaling pathway_Homo sapiens_hsa033202.29446694
10Staphylococcus aureus infection_Homo sapiens_hsa051502.26536409
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.17236926
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.16557630
13Graft-versus-host disease_Homo sapiens_hsa053322.12923549
14Autoimmune thyroid disease_Homo sapiens_hsa053202.05712818
15Arginine biosynthesis_Homo sapiens_hsa002202.00838099
16Fatty acid metabolism_Homo sapiens_hsa012121.99324519
17Tryptophan metabolism_Homo sapiens_hsa003801.97916565
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.97567797
19Propanoate metabolism_Homo sapiens_hsa006401.90125736
20Tuberculosis_Homo sapiens_hsa051521.83663762
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.79111508
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77537594
23Asthma_Homo sapiens_hsa053101.74527804
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.72438136
25Pyruvate metabolism_Homo sapiens_hsa006201.69885748
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.66706075
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.64628923
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.62352482
29Rheumatoid arthritis_Homo sapiens_hsa053231.60086695
30Primary immunodeficiency_Homo sapiens_hsa053401.59258486
31Caffeine metabolism_Homo sapiens_hsa002321.57690114
32Type I diabetes mellitus_Homo sapiens_hsa049401.57549596
33B cell receptor signaling pathway_Homo sapiens_hsa046621.56858900
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53884728
35Butanoate metabolism_Homo sapiens_hsa006501.53019772
36Toxoplasmosis_Homo sapiens_hsa051451.51593974
37Bile secretion_Homo sapiens_hsa049761.49975446
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.49947392
39TNF signaling pathway_Homo sapiens_hsa046681.48354257
40Histidine metabolism_Homo sapiens_hsa003401.48138229
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44919940
42Antigen processing and presentation_Homo sapiens_hsa046121.43305689
43Hematopoietic cell lineage_Homo sapiens_hsa046401.43183036
44Peroxisome_Homo sapiens_hsa041461.43011297
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.41400620
46Sulfur metabolism_Homo sapiens_hsa009201.37502173
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.36156970
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36012617
49Fatty acid elongation_Homo sapiens_hsa000621.35968519
50Acute myeloid leukemia_Homo sapiens_hsa052211.35957553
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35329801
52Chemical carcinogenesis_Homo sapiens_hsa052041.33103200
53Viral myocarditis_Homo sapiens_hsa054161.32006839
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.31805350
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31637018
56Influenza A_Homo sapiens_hsa051641.28658997
57ABC transporters_Homo sapiens_hsa020101.27346499
58Steroid biosynthesis_Homo sapiens_hsa001001.22846899
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.20512222
60Fat digestion and absorption_Homo sapiens_hsa049751.19876824
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18307371
62Fatty acid biosynthesis_Homo sapiens_hsa000611.18245121
63Starch and sucrose metabolism_Homo sapiens_hsa005001.17419457
64Chemokine signaling pathway_Homo sapiens_hsa040621.15263336
65Salmonella infection_Homo sapiens_hsa051321.09908411
66Prion diseases_Homo sapiens_hsa050201.09153711
67Measles_Homo sapiens_hsa051621.08673463
68T cell receptor signaling pathway_Homo sapiens_hsa046601.08153828
69* Lysosome_Homo sapiens_hsa041421.07620823
70Other glycan degradation_Homo sapiens_hsa005111.07395535
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07071249
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05100664
73Hepatitis C_Homo sapiens_hsa051601.04662954
74Maturity onset diabetes of the young_Homo sapiens_hsa049501.02634832
75African trypanosomiasis_Homo sapiens_hsa051431.01200355
76Steroid hormone biosynthesis_Homo sapiens_hsa001401.00685869
77Herpes simplex infection_Homo sapiens_hsa051680.97561717
78Retinol metabolism_Homo sapiens_hsa008300.97505875
79Phenylalanine metabolism_Homo sapiens_hsa003600.97023845
80Selenocompound metabolism_Homo sapiens_hsa004500.95851063
81beta-Alanine metabolism_Homo sapiens_hsa004100.95360796
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.94804935
83Glycerolipid metabolism_Homo sapiens_hsa005610.94543594
84Tyrosine metabolism_Homo sapiens_hsa003500.92626010
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.90994245
86Legionellosis_Homo sapiens_hsa051340.90056037
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.89275018
88Shigellosis_Homo sapiens_hsa051310.87069065
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86313584
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86193630
91VEGF signaling pathway_Homo sapiens_hsa043700.85096913
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83831550
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83480429
94Vitamin B6 metabolism_Homo sapiens_hsa007500.82885748
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80907149
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80116422
97Carbon metabolism_Homo sapiens_hsa012000.80075251
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79461619
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78282082
100Platelet activation_Homo sapiens_hsa046110.77337909
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76809060
102Hepatitis B_Homo sapiens_hsa051610.75657944
103Notch signaling pathway_Homo sapiens_hsa043300.74175224
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71730432
105Endocytosis_Homo sapiens_hsa041440.71268629
106Glucagon signaling pathway_Homo sapiens_hsa049220.69212865
107Malaria_Homo sapiens_hsa051440.69076858
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.67473434
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66272069
110Apoptosis_Homo sapiens_hsa042100.65716920
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.65433197
112Linoleic acid metabolism_Homo sapiens_hsa005910.64909306
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64829831
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62908979
115Insulin resistance_Homo sapiens_hsa049310.62555420
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61266222
117Prolactin signaling pathway_Homo sapiens_hsa049170.59065027
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.58796488
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.58591075
120Collecting duct acid secretion_Homo sapiens_hsa049660.58545022
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58378531
122Dorso-ventral axis formation_Homo sapiens_hsa043200.57866173
123Amoebiasis_Homo sapiens_hsa051460.57724089
124ECM-receptor interaction_Homo sapiens_hsa045120.57321643
125Biosynthesis of amino acids_Homo sapiens_hsa012300.57254437
126Bladder cancer_Homo sapiens_hsa052190.57142731
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56518286
128Drug metabolism - other enzymes_Homo sapiens_hsa009830.55457282
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55450143
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54709025
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54354603
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53660495
133Chronic myeloid leukemia_Homo sapiens_hsa052200.53390971
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50009095
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49285781
136Non-small cell lung cancer_Homo sapiens_hsa052230.48219464
137Vibrio cholerae infection_Homo sapiens_hsa051100.47813342
138Arginine and proline metabolism_Homo sapiens_hsa003300.47423444
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47285779
140Pancreatic cancer_Homo sapiens_hsa052120.47110281
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.46761869
142Pentose phosphate pathway_Homo sapiens_hsa000300.46399147
143GnRH signaling pathway_Homo sapiens_hsa049120.45652996
144Phagosome_Homo sapiens_hsa041450.44830800
145Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44479243
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43824163
147Vitamin digestion and absorption_Homo sapiens_hsa049770.41092973
148Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39926677
149Arachidonic acid metabolism_Homo sapiens_hsa005900.39618568
150Protein digestion and absorption_Homo sapiens_hsa049740.38871287
151Sulfur relay system_Homo sapiens_hsa041220.38802076
152Galactose metabolism_Homo sapiens_hsa000520.38329454
153Renin-angiotensin system_Homo sapiens_hsa046140.37875203
154Glutathione metabolism_Homo sapiens_hsa004800.37740584
155Fructose and mannose metabolism_Homo sapiens_hsa000510.37691288
156HTLV-I infection_Homo sapiens_hsa051660.36725821
157Central carbon metabolism in cancer_Homo sapiens_hsa052300.35445019
158Epstein-Barr virus infection_Homo sapiens_hsa051690.33512722
159Pertussis_Homo sapiens_hsa051330.33191278
160AMPK signaling pathway_Homo sapiens_hsa041520.32108119
161Cysteine and methionine metabolism_Homo sapiens_hsa002700.31755508
162Lysine degradation_Homo sapiens_hsa003100.31463198
163Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30404517
164Focal adhesion_Homo sapiens_hsa045100.30022597
165Renal cell carcinoma_Homo sapiens_hsa052110.29418289
166MAPK signaling pathway_Homo sapiens_hsa040100.28618257
167Estrogen signaling pathway_Homo sapiens_hsa049150.28602899
168Folate biosynthesis_Homo sapiens_hsa007900.28013538
169Choline metabolism in cancer_Homo sapiens_hsa052310.27813876
170Type II diabetes mellitus_Homo sapiens_hsa049300.26724027
171Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.25786267
172HIF-1 signaling pathway_Homo sapiens_hsa040660.24757246
173Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.24692647
174N-Glycan biosynthesis_Homo sapiens_hsa005100.24669550
175mTOR signaling pathway_Homo sapiens_hsa041500.24393162
176Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.23876300
177Thyroid hormone synthesis_Homo sapiens_hsa049180.23553583
178Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21909515

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