ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cilium or flagellum-dependent cell motility (GO:0001539)	4.36184286
2	axonemal dynein complex assembly (GO:0070286)	4.32947759
3	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.07948306
4	drug catabolic process (GO:0042737)	4.03902816
5	exogenous drug catabolic process (GO:0042738)	3.92083842
6	cilium movement (GO:0003341)	3.87266053
7	epoxygenase P450 pathway (GO:0019373)	3.61247202
8	ethanol metabolic process (GO:0006067)	3.61059760
9	ethanol oxidation (GO:0006069)	3.55368987
10	epithelial cilium movement (GO:0003351)	3.47227986
11	motile cilium assembly (GO:0044458)	3.11164987
12	primary alcohol catabolic process (GO:0034310)	2.95246470
13	drug metabolic process (GO:0017144)	2.88568366
14	macroautophagy (GO:0016236)	2.86191470
15	axoneme assembly (GO:0035082)	2.85404422
16	flavonoid metabolic process (GO:0009812)	2.84774016
17	indole-containing compound catabolic process (GO:0042436)	2.82619776
18	indolalkylamine catabolic process (GO:0046218)	2.82619776
19	tryptophan catabolic process (GO:0006569)	2.82619776
20	toxin transport (GO:1901998)	2.77253996
21	negative regulation of humoral immune response (GO:0002921)	2.77122531
22	omega-hydroxylase P450 pathway (GO:0097267)	2.74865270
23	cellular glucuronidation (GO:0052695)	2.74572759
24	drug transmembrane transport (GO:0006855)	2.70262836
25	drug transport (GO:0015893)	2.68459436
26	glucuronate metabolic process (GO:0019585)	2.68053780
27	uronic acid metabolic process (GO:0006063)	2.68053780
28	quaternary ammonium group transport (GO:0015697)	2.67774675
29	negative regulation of complement activation (GO:0045916)	2.58892650
30	regulation of protein activation cascade (GO:2000257)	2.58539974
31	regulation of complement activation (GO:0030449)	2.58318975
32	aromatic amino acid family catabolic process (GO:0009074)	2.57225043
33	negative regulation of protein activation cascade (GO:2000258)	2.53218158
34	bile acid and bile salt transport (GO:0015721)	2.52931508
35	bile acid metabolic process (GO:0008206)	2.50033288
36	bile acid biosynthetic process (GO:0006699)	2.48353741
37	complement activation, alternative pathway (GO:0006957)	2.45233029
38	regulation of triglyceride catabolic process (GO:0010896)	2.43499557
39	organic cation transport (GO:0015695)	2.42298525
40	alkaloid metabolic process (GO:0009820)	2.39352173
41	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	2.37391603
42	carnitine transport (GO:0015879)	2.37259854
43	amino-acid betaine transport (GO:0015838)	2.37259854
44	amino-acid betaine metabolic process (GO:0006577)	2.35388406
45	oxidative demethylation (GO:0070989)	2.35209421
46	primary alcohol metabolic process (GO:0034308)	2.33140198
47	phenol-containing compound catabolic process (GO:0019336)	2.32066256
48	positive regulation of icosanoid secretion (GO:0032305)	2.30012294
49	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.28655969
50	L-phenylalanine catabolic process (GO:0006559)	2.28655969
51	phenylpropanoid metabolic process (GO:0009698)	2.25408041
52	fucose catabolic process (GO:0019317)	2.24841576
53	L-fucose metabolic process (GO:0042354)	2.24841576
54	L-fucose catabolic process (GO:0042355)	2.24841576
55	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.24315365
56	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.24315365
57	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.22949946
58	excretion (GO:0007588)	2.22333681
59	arginine metabolic process (GO:0006525)	2.18548336
60	positive regulation of fatty acid transport (GO:2000193)	2.18318757
61	cellular ketone body metabolic process (GO:0046950)	2.18115948
62	cellular response to exogenous dsRNA (GO:0071360)	2.16049163
63	positive regulation of fatty acid oxidation (GO:0046321)	2.15846557
64	xenobiotic metabolic process (GO:0006805)	2.15340316
65	carnitine transmembrane transport (GO:1902603)	2.15231886
66	benzene-containing compound metabolic process (GO:0042537)	2.15179262
67	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.14314466
68	vitamin transmembrane transport (GO:0035461)	2.13212683
69	angiotensin maturation (GO:0002003)	2.12657190
70	indolalkylamine metabolic process (GO:0006586)	2.11637912
71	glyoxylate metabolic process (GO:0046487)	2.11431516
72	thyroid hormone metabolic process (GO:0042403)	2.10784313
73	one-carbon compound transport (GO:0019755)	2.10408886
74	tryptophan metabolic process (GO:0006568)	2.09793440
75	digestion (GO:0007586)	2.09193400
76	hydrogen peroxide biosynthetic process (GO:0050665)	2.08787740
77	sulfate transmembrane transport (GO:1902358)	2.08402859
78	arginine catabolic process (GO:0006527)	2.08026977
79	regulation of cilium movement (GO:0003352)	2.05944275
80	L-phenylalanine metabolic process (GO:0006558)	2.05700889
81	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.05700889
82	cellular biogenic amine catabolic process (GO:0042402)	2.05618151
83	amine catabolic process (GO:0009310)	2.05618151
84	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.04392734
85	thyroid hormone generation (GO:0006590)	2.03628607
86	positive regulation of digestive system process (GO:0060456)	2.02550462
87	high-density lipoprotein particle remodeling (GO:0034375)	2.01142110
88	neurotransmitter biosynthetic process (GO:0042136)	2.00767240
89	reactive oxygen species biosynthetic process (GO:1903409)	1.99664160
90	phosphatidylinositol acyl-chain remodeling (GO:0036149)	1.98752502
91	phosphate ion homeostasis (GO:0055062)	1.97284767
92	trivalent inorganic anion homeostasis (GO:0072506)	1.97284767
93	parturition (GO:0007567)	1.96363083
94	multicellular organismal water homeostasis (GO:0050891)	1.94984058
95	water homeostasis (GO:0030104)	1.94775915
96	neurotransmitter metabolic process (GO:0042133)	1.94408939
97	lung secretory cell differentiation (GO:0061140)	1.93873901
98	glomerular filtration (GO:0003094)	1.93745674
99	amyloid precursor protein catabolic process (GO:0042987)	1.93695298
100	diterpenoid biosynthetic process (GO:0016102)	1.93690079

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.51080884
2	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.39562026
3	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.24169305
4	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.08819383
5	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.98683699
6	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.84043107
7	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.78314205
8	AHR_22903824_ChIP-Seq_MCF-7_Human	1.69512763
9	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.68757997
10	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.64948319
11	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.63883704
12	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.63518704
13	DROSHA_22980978_ChIP-Seq_HELA_Human	1.62431158
14	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.60046424
15	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.57848750
16	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.48909773
17	VDR_22108803_ChIP-Seq_LS180_Human	1.45788792
18	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.45334133
19	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.42698128
20	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.42285619
21	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.38808321
22	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.37459124
23	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.37310184
24	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.35287246
25	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.29427455
26	GATA4_25053715_ChIP-Seq_YYC3_Human	1.28112301
27	* SOX2_20726797_ChIP-Seq_SW620_Human	1.27659110
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.25679052
29	BCAT_22108803_ChIP-Seq_LS180_Human	1.25653313
30	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.25634131
31	ZNF274_21170338_ChIP-Seq_K562_Hela	1.23694692
32	ER_23166858_ChIP-Seq_MCF-7_Human	1.21506260
33	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15786188
34	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.12725043
35	* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12521975
36	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.11064710
37	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.10468524
38	VDR_24787735_ChIP-Seq_THP-1_Human	1.10428551
39	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.10009874
40	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.09931389
41	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.08424208
42	GBX2_23144817_ChIP-Seq_PC3_Human	1.07958555
43	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.07175228
44	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.02092076
45	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.01997146
46	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.01279758
47	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.01089426
48	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.01001726
49	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.00445244
50	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.00017523
51	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.98246136
52	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.98160121
53	CJUN_26792858_Chip-Seq_BT549_Human	0.96168173
54	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.94588287
55	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.91821611
56	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.91814218
57	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.91731412
58	TP63_23658742_ChIP-Seq_EP156T_Human	0.91629354
59	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.91019729
60	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.90150435
61	TCF4_22108803_ChIP-Seq_LS180_Human	0.89097468
62	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.88954972
63	CDX2_22108803_ChIP-Seq_LS180_Human	0.88374592
64	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.88097960
65	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.87947097
66	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.87947097
67	KLF5_25053715_ChIP-Seq_YYC3_Human	0.87696821
68	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.87499496
69	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.86783276
70	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.86277683
71	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.85065990
72	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.84539956
73	AR_25329375_ChIP-Seq_VCAP_Human	0.84042777
74	AR_20517297_ChIP-Seq_VCAP_Human	0.83946006
75	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.83766041
76	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.83068481
77	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.83000956
78	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.82887108
79	SMAD4_21799915_ChIP-Seq_A2780_Human	0.82114591
80	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.81343128
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.81171612
82	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.80711980
83	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.80486998
84	* PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.80111167
85	RXR_22108803_ChIP-Seq_LS180_Human	0.79967248
86	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.79033324
87	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.78813653
88	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.78476628
89	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.78282402
90	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.77875894
91	IRF8_27001747_Chip-Seq_BMDM_Mouse	0.77859656
92	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.77138544
93	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.76924942
94	GATA1_22025678_ChIP-Seq_K562_Human	0.76281212
95	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.76112052
96	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.75826125
97	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.74782049
98	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.74277273
99	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.73771122
100	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.73661797

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	3.77425743
2	MP0008875_abnormal_xenobiotic_pharmacok	3.56452579
3	MP0003195_calcinosis	3.48986998
4	MP0005365_abnormal_bile_salt	3.43658741
5	MP0005085_abnormal_gallbladder_physiolo	3.15354214
6	MP0005360_urolithiasis	2.81213972
7	MP0004043_abnormal_pH_regulation	2.69592581
8	MP0002876_abnormal_thyroid_physiology	2.48394941
9	MP0002138_abnormal_hepatobiliary_system	2.45764775
10	MP0001666_abnormal_nutrient_absorption	2.18127578
11	MP0004019_abnormal_vitamin_homeostasis	2.12851187
12	MP0010329_abnormal_lipoprotein_level	1.91477592
13	MP0000383_abnormal_hair_follicle	1.90888451
14	MP0004264_abnormal_extraembryonic_tissu	1.87959376
15	MP0008004_abnormal_stomach_pH	1.86478584
16	MP0003252_abnormal_bile_duct	1.84641459
17	MP0005083_abnormal_biliary_tract	1.78945607
18	MP0003724_increased_susceptibility_to	1.77638357
19	MP0001756_abnormal_urination	1.74957643
20	MP0009780_abnormal_chondrocyte_physiolo	1.72869979
21	MP0009643_abnormal_urine_homeostasis	1.69939959
22	MP0002653_abnormal_ependyma_morphology	1.69182465
23	MP0009840_abnormal_foam_cell	1.66433271
24	MP0001765_abnormal_ion_homeostasis	1.63517956
25	MP0001664_abnormal_digestion	1.55856911
26	MP0010386_abnormal_urinary_bladder	1.52686399
27	MP0003183_abnormal_peptide_metabolism	1.52565801
28	MP0010678_abnormal_skin_adnexa	1.51358098
29	MP0003191_abnormal_cellular_cholesterol	1.45387037
30	MP0003011_delayed_dark_adaptation	1.44581729
31	MP0000538_abnormal_urinary_bladder	1.44402038
32	MP0005332_abnormal_amino_acid	1.37388441
33	MP0002132_abnormal_respiratory_system	1.31828613
34	MP0002909_abnormal_adrenal_gland	1.29938464
35	MP0002118_abnormal_lipid_homeostasis	1.29145188
36	MP0001873_stomach_inflammation	1.28106173
37	MP0002136_abnormal_kidney_physiology	1.26659898
38	MP0010155_abnormal_intestine_physiology	1.26506016
39	MP0004782_abnormal_surfactant_physiolog	1.23823411
40	MP0000465_gastrointestinal_hemorrhage	1.21106214
41	MP0005646_abnormal_pituitary_gland	1.18797047
42	MP0005636_abnormal_mineral_homeostasis	1.18598521
43	MP0005058_abnormal_lysosome_morphology	1.18547670
44	MP0002168_other_aberrant_phenotype	1.18450349
45	MP0001663_abnormal_digestive_system	1.16230305
46	MP0003868_abnormal_feces_composition	1.13795828
47	MP0008872_abnormal_physiological_respon	1.12885868
48	MP0002277_abnormal_respiratory_mucosa	1.12551568
49	MP0004885_abnormal_endolymph	1.11812562
50	MP0003638_abnormal_response/metabolism_	1.10373623
51	MP0004133_heterotaxia	1.08745588
52	MP0000230_abnormal_systemic_arterial	1.07012911
53	MP0004883_abnormal_blood_vessel	1.04386038
54	MP0003879_abnormal_hair_cell	1.04115949
55	MP0003866_abnormal_defecation	1.04052966
56	MP0003878_abnormal_ear_physiology	1.03152164
57	MP0005377_hearing/vestibular/ear_phenot	1.03152164
58	MP0005310_abnormal_salivary_gland	1.02174873
59	MP0000470_abnormal_stomach_morphology	1.01474524
60	MP0006082_CNS_inflammation	1.00804971
61	MP0002148_abnormal_hypersensitivity_rea	1.00703703
62	MP0005167_abnormal_blood-brain_barrier	0.98040499
63	MP0002254_reproductive_system_inflammat	0.97190544
64	MP0005381_digestive/alimentary_phenotyp	0.95116705
65	MP0001485_abnormal_pinna_reflex	0.93904525
66	MP0005164_abnormal_response_to	0.90618951
67	MP0001764_abnormal_homeostasis	0.90572604
68	MP0003045_fibrosis	0.90517121
69	MP0009764_decreased_sensitivity_to	0.90388764
70	MP0005409_darkened_coat_color	0.88600523
71	MP0000427_abnormal_hair_cycle	0.85542624
72	MP0003303_peritoneal_inflammation	0.85051447
73	MP0001501_abnormal_sleep_pattern	0.83907754
74	MP0001958_emphysema	0.82762029
75	MP0005448_abnormal_energy_balance	0.82357529
76	MP0005025_abnormal_response_to	0.82331298
77	MP0010368_abnormal_lymphatic_system	0.82007283
78	MP0009785_altered_susceptibility_to	0.80063588
79	MP0002098_abnormal_vibrissa_morphology	0.79582043
80	MP0005595_abnormal_vascular_smooth	0.76967449
81	MP0008469_abnormal_protein_level	0.76964365
82	MP0003300_gastrointestinal_ulcer	0.76644262
83	MP0005670_abnormal_white_adipose	0.75823524
84	MP0001845_abnormal_inflammatory_respons	0.74843934
85	MP0005551_abnormal_eye_electrophysiolog	0.74674472
86	MP0005408_hypopigmentation	0.73132930
87	MP0003953_abnormal_hormone_level	0.73100859
88	MP0000681_abnormal_thyroid_gland	0.72357617
89	MP0001835_abnormal_antigen_presentation	0.72112726
90	MP0009642_abnormal_blood_homeostasis	0.71810691
91	MP0000249_abnormal_blood_vessel	0.71658109
92	MP0001533_abnormal_skeleton_physiology	0.70796490
93	MP0000566_synostosis	0.69180682
94	MP0002419_abnormal_innate_immunity	0.67309673
95	MP0005367_renal/urinary_system_phenotyp	0.67295739
96	MP0000516_abnormal_urinary_system	0.67295739
97	MP0000604_amyloidosis	0.66990354
98	MP0001790_abnormal_immune_system	0.66836198
99	MP0005387_immune_system_phenotype	0.66836198
100	MP0005084_abnormal_gallbladder_morpholo	0.66345320

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent/shortened dynein arms (HP:0200106)	5.32799386
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.32799386
3	Abnormal ciliary motility (HP:0012262)	4.89250960
4	Abnormal respiratory epithelium morphology (HP:0012253)	4.88646784
5	Abnormal respiratory motile cilium morphology (HP:0005938)	4.88646784
6	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.47103754
7	Abnormal respiratory motile cilium physiology (HP:0012261)	4.45559875
8	Hyperactive renin-angiotensin system (HP:0000841)	4.19252591
9	Rhinitis (HP:0012384)	3.73348588
10	Decreased circulating renin level (HP:0003351)	3.38720740
11	Complement deficiency (HP:0004431)	3.05504777
12	Chronic bronchitis (HP:0004469)	3.01256179
13	Abnormality of renin-angiotensin system (HP:0000847)	2.98840286
14	Systemic lupus erythematosus (HP:0002725)	2.96782562
15	Bronchiectasis (HP:0002110)	2.95917913
16	Tubular atrophy (HP:0000092)	2.95167796
17	Hyperaldosteronism (HP:0000859)	2.94270686
18	Metabolic alkalosis (HP:0200114)	2.93131635
19	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.91175260
20	True hermaphroditism (HP:0010459)	2.77502019
21	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.73377146
22	Abnormality of chloride homeostasis (HP:0011422)	2.73014741
23	Renal salt wasting (HP:0000127)	2.72829529
24	Pancreatic cysts (HP:0001737)	2.69154654
25	Abnormality of the renal medulla (HP:0100957)	2.69018160
26	Glomerulonephritis (HP:0000099)	2.64107265
27	Alkalosis (HP:0001948)	2.58763036
28	Abnormality of polysaccharide metabolism (HP:0011012)	2.58400543
29	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.58400543
30	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.58400543
31	Nasal polyposis (HP:0100582)	2.53219097
32	Tubulointerstitial fibrosis (HP:0005576)	2.52486545
33	Hypokalemic alkalosis (HP:0001949)	2.52408983
34	Cystic liver disease (HP:0006706)	2.51504759
35	Urinary glycosaminoglycan excretion (HP:0003541)	2.49561984
36	Mucopolysacchariduria (HP:0008155)	2.49561984
37	Nephronophthisis (HP:0000090)	2.49072016
38	Abnormality of the nasal mucosa (HP:0000433)	2.44869799
39	Abnormality of renal excretion (HP:0011036)	2.39462140
40	Abnormality of the renal cortex (HP:0011035)	2.36374967
41	Pancreatic fibrosis (HP:0100732)	2.36208822
42	Hyperventilation (HP:0002883)	2.34124367
43	Nephritis (HP:0000123)	2.33568330
44	Polydipsia (HP:0001959)	2.32538744
45	Abnormal drinking behavior (HP:0030082)	2.32538744
46	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.25397570
47	Abnormality of midbrain morphology (HP:0002418)	2.24017103
48	Molar tooth sign on MRI (HP:0002419)	2.24017103
49	Polyuria (HP:0000103)	2.22705797
50	Abnormality of complement system (HP:0005339)	2.22329931
51	Congenital sensorineural hearing impairment (HP:0008527)	2.20925120
52	Tubulointerstitial nephritis (HP:0001970)	2.16755637
53	Abnormality of proline metabolism (HP:0010907)	2.16130737
54	Hydroxyprolinuria (HP:0003080)	2.16130737
55	Conjugated hyperbilirubinemia (HP:0002908)	2.16035699
56	Abnormality of liposaccharide metabolism (HP:0010968)	2.15820981
57	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.15820981
58	Abnormality of glycolipid metabolism (HP:0010969)	2.15820981
59	Dysostosis multiplex (HP:0000943)	2.14949632
60	Tubulointerstitial abnormality (HP:0001969)	2.11308933
61	Vacuolated lymphocytes (HP:0001922)	2.09844751
62	Amelogenesis imperfecta (HP:0000705)	2.09706735
63	Increased cerebral lipofuscin (HP:0011813)	2.09543942
64	Hypokalemia (HP:0002900)	2.09063891
65	Facial shape deformation (HP:0011334)	2.08487391
66	Potter facies (HP:0002009)	2.08487391
67	Abnormal urine output (HP:0012590)	2.08266466
68	Chronic hepatic failure (HP:0100626)	2.08090822
69	Chronic sinusitis (HP:0011109)	2.02358579
70	Malnutrition (HP:0004395)	1.97556777
71	Stage 5 chronic kidney disease (HP:0003774)	1.97515155
72	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.94328421
73	Glycosuria (HP:0003076)	1.93293167
74	Abnormality of urine glucose concentration (HP:0011016)	1.93293167
75	Vascular calcification (HP:0004934)	1.93045643
76	Fat malabsorption (HP:0002630)	1.92784743
77	Infertility (HP:0000789)	1.89304768
78	Congenital hepatic fibrosis (HP:0002612)	1.86944151
79	Recurrent sinusitis (HP:0011108)	1.86855669
80	Myositis (HP:0100614)	1.86680272
81	Intrahepatic cholestasis (HP:0001406)	1.85392308
82	Abnormality of potassium homeostasis (HP:0011042)	1.82536424
83	Occipital encephalocele (HP:0002085)	1.81433884
84	Bronchitis (HP:0012387)	1.80590459
85	Increased circulating renin level (HP:0000848)	1.78204077
86	Xanthomatosis (HP:0000991)	1.76416515
87	Recurrent gram-negative bacterial infections (HP:0005420)	1.76229658
88	Elevated erythrocyte sedimentation rate (HP:0003565)	1.69924401
89	Pigmentary retinal degeneration (HP:0001146)	1.69484974
90	Abolished electroretinogram (ERG) (HP:0000550)	1.69365668
91	Furrowed tongue (HP:0000221)	1.67875377
92	Male pseudohermaphroditism (HP:0000037)	1.67624912
93	Cardiovascular calcification (HP:0011915)	1.66814091
94	Thyroid-stimulating hormone excess (HP:0002925)	1.66776277
95	Loss of speech (HP:0002371)	1.64751890
96	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.63472698
97	Orchitis (HP:0100796)	1.63156819
98	Interstitial pulmonary disease (HP:0006530)	1.62459021
99	Optic neuritis (HP:0100653)	1.60567011
100	Retrobulbar optic neuritis (HP:0100654)	1.60567011

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.82515097
2	MAPK15	3.78895570
3	EPHA2	2.90747600
4	TAOK3	2.55858326
5	MAPKAPK3	2.29610202
6	OXSR1	2.06549970
7	ADRBK2	1.92423578
8	STK39	1.81185977
9	WNK3	1.77313199
10	EPHA3	1.76683537
11	FER	1.70993000
12	GRK1	1.68592294
13	PIK3CA	1.67492927
14	MAP2K6	1.62843455
15	SIK1	1.48097074
16	ERN1	1.45943212
17	ACVR1B	1.44878121
18	MST1R	1.43605495
19	PINK1	1.39776462
20	TNK2	1.38586838
21	KIT	1.26395024
22	TRIB3	1.21522214
23	NLK	1.18533147
24	MAP2K2	1.13402087
25	EPHB2	1.12868352
26	PKN2	1.12754085
27	CHUK	1.09283976
28	RPS6KA2	1.08570003
29	WNK4	1.07629182
30	EPHB1	1.06514418
31	TRPM7	1.05819906
32	TBK1	1.03521023
33	SGK2	1.03255570
34	INSRR	1.02478581
35	MATK	0.99191576
36	IKBKE	0.98883160
37	MUSK	0.98623034
38	ADRBK1	0.96013744
39	GRK7	0.94043600
40	RIPK1	0.92225437
41	MYLK	0.91473547
42	AKT3	0.90702784
43	TYK2	0.89154267
44	MAP3K2	0.88756101
45	TGFBR2	0.87484735
46	DAPK2	0.86654693
47	PRKAA2	0.86310637
48	LMTK2	0.85416532
49	IKBKB	0.85397005
50	MAP4K2	0.84183123
51	ZAP70	0.84116071
52	MAP3K3	0.81674320
53	CAMK1D	0.80662452
54	MAP3K6	0.80273038
55	GRK6	0.79897253
56	CDC42BPA	0.77453983
57	ERBB2	0.77208046
58	TIE1	0.75980567
59	MAPK13	0.75263859
60	SGK223	0.73609961
61	SGK494	0.73609961
62	IRAK1	0.72373452
63	CSF1R	0.72092865
64	TXK	0.71862508
65	PRKD2	0.68466970
66	RPS6KA6	0.68205735
67	BLK	0.65136346
68	FGFR3	0.64979214
69	MAP2K4	0.64458368
70	JAK1	0.62720330
71	PDPK1	0.61053160
72	SGK3	0.60917909
73	HIPK2	0.60614777
74	PRKCE	0.59797508
75	MARK2	0.59711455
76	PRKCZ	0.59144686
77	MAP3K7	0.58748247
78	CAMKK2	0.58106168
79	CSK	0.56885067
80	LATS1	0.55826959
81	TLK1	0.54440240
82	PTK6	0.53532772
83	PRKCQ	0.52507298
84	TAOK1	0.51681961
85	CASK	0.49552927
86	BMPR1B	0.49121139
87	GSK3A	0.48110170
88	MAP4K1	0.47952591
89	RPS6KL1	0.47616060
90	RPS6KC1	0.47616060
91	PAK3	0.47165889
92	MET	0.47106105
93	PIK3CG	0.47001356
94	DYRK1B	0.46929866
95	RET	0.46928976
96	BTK	0.46846059
97	PDK1	0.46113311
98	TEC	0.44342505
99	CAMK1G	0.44268268
100	MAPK7	0.43975082

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.74166181
2	Caffeine metabolism_Homo sapiens_hsa00232	2.58175753
3	Chemical carcinogenesis_Homo sapiens_hsa05204	2.57583747
4	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.51287040
5	Histidine metabolism_Homo sapiens_hsa00340	2.48143208
6	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.44401711
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.38734574
8	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.33008318
9	Retinol metabolism_Homo sapiens_hsa00830	2.28872232
10	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.22068398
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.93740067
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.86096557
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.78316901
14	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.76745652
15	Complement and coagulation cascades_Homo sapiens_hsa04610	1.76724330
16	Phenylalanine metabolism_Homo sapiens_hsa00360	1.59969087
17	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.59756928
18	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.56497688
19	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.56266342
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.52325069
21	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.49085492
22	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.47969434
23	Butanoate metabolism_Homo sapiens_hsa00650	1.45718499
24	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.44872400
25	Tyrosine metabolism_Homo sapiens_hsa00350	1.42991244
26	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.42863548
27	Fat digestion and absorption_Homo sapiens_hsa04975	1.41284988
28	ABC transporters_Homo sapiens_hsa02010	1.38629399
29	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.37917430
30	Fatty acid degradation_Homo sapiens_hsa00071	1.37339223
31	Peroxisome_Homo sapiens_hsa04146	1.30378760
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.28909909
33	Sulfur metabolism_Homo sapiens_hsa00920	1.24788741
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.23704204
35	Bile secretion_Homo sapiens_hsa04976	1.20520725
36	Other glycan degradation_Homo sapiens_hsa00511	1.20146116
37	Asthma_Homo sapiens_hsa05310	1.18356443
38	beta-Alanine metabolism_Homo sapiens_hsa00410	1.17949805
39	PPAR signaling pathway_Homo sapiens_hsa03320	1.17132594
40	Sphingolipid metabolism_Homo sapiens_hsa00600	1.16418418
41	Mineral absorption_Homo sapiens_hsa04978	1.05031130
42	Lysosome_Homo sapiens_hsa04142	1.03016250
43	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.99240798
44	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.98824027
45	Nitrogen metabolism_Homo sapiens_hsa00910	0.97778836
46	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.97500844
47	Glycerolipid metabolism_Homo sapiens_hsa00561	0.92392173
48	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.91066123
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.90553057
50	Renin-angiotensin system_Homo sapiens_hsa04614	0.89079067
51	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.81434365
52	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.80040259
53	Allograft rejection_Homo sapiens_hsa05330	0.79264169
54	Graft-versus-host disease_Homo sapiens_hsa05332	0.77313636
55	Protein digestion and absorption_Homo sapiens_hsa04974	0.75136973
56	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.74373951
57	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.70768077
58	Type I diabetes mellitus_Homo sapiens_hsa04940	0.69902846
59	Pancreatic secretion_Homo sapiens_hsa04972	0.69757745
60	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.69524520
61	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.68903731
62	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.68677890
63	Arginine biosynthesis_Homo sapiens_hsa00220	0.64275819
64	Pertussis_Homo sapiens_hsa05133	0.60246589
65	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.55781900
66	Insulin resistance_Homo sapiens_hsa04931	0.55610559
67	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.54453526
68	Rheumatoid arthritis_Homo sapiens_hsa05323	0.51633934
69	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.51059157
70	Salivary secretion_Homo sapiens_hsa04970	0.50580533
71	Collecting duct acid secretion_Homo sapiens_hsa04966	0.49178814
72	Phototransduction_Homo sapiens_hsa04744	0.48920294
73	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.47867247
74	Hepatitis C_Homo sapiens_hsa05160	0.45799114
75	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.44427320
76	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.43691370
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.41966020
78	Leishmaniasis_Homo sapiens_hsa05140	0.41253575
79	Propanoate metabolism_Homo sapiens_hsa00640	0.40701968
80	Glutathione metabolism_Homo sapiens_hsa00480	0.40506750
81	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.39646556
82	Fatty acid metabolism_Homo sapiens_hsa01212	0.36562452
83	Renin secretion_Homo sapiens_hsa04924	0.36249267
84	Cocaine addiction_Homo sapiens_hsa05030	0.35858182
85	Tuberculosis_Homo sapiens_hsa05152	0.34582941
86	Serotonergic synapse_Homo sapiens_hsa04726	0.34171000
87	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.33393433
88	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.31978093
89	Arginine and proline metabolism_Homo sapiens_hsa00330	0.30048157
90	Phagosome_Homo sapiens_hsa04145	0.29579988
91	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.27359747
92	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.26903751
93	TNF signaling pathway_Homo sapiens_hsa04668	0.25265239
94	Choline metabolism in cancer_Homo sapiens_hsa05231	0.24334259
95	Metabolic pathways_Homo sapiens_hsa01100	0.24013631
96	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.23914952
97	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.23593288
98	Platelet activation_Homo sapiens_hsa04611	0.23556110
99	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.23111448
100	Amoebiasis_Homo sapiens_hsa05146	0.23101080

ARSD

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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