ARSE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Arylsulfatase E is a member of the sulfatase family. It is glycosylated postranslationally and localized to the golgi apparatus. Sulfatases are essential for the correct composition of bone and cartilage matrix. X-linked chondrodysplasia punctata, a disease characterized by abnormalities in cartilage and bone development, has been linked to mutations in this gene. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the Y chromosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cholesterol esterification (GO:0010872)6.59660949
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.54548607
3L-phenylalanine catabolic process (GO:0006559)6.54548607
4regulation of protein activation cascade (GO:2000257)6.50637550
5negative regulation of fibrinolysis (GO:0051918)6.48371395
6regulation of fibrinolysis (GO:0051917)6.32697486
7high-density lipoprotein particle remodeling (GO:0034375)6.28500595
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.23015321
9L-phenylalanine metabolic process (GO:0006558)6.23015321
10regulation of complement activation (GO:0030449)6.13465245
11peptidyl-glutamic acid carboxylation (GO:0017187)6.10745672
12protein carboxylation (GO:0018214)6.10745672
13plasma lipoprotein particle assembly (GO:0034377)5.94474085
14glyoxylate metabolic process (GO:0046487)5.93767951
15phospholipid efflux (GO:0033700)5.92190964
16very-low-density lipoprotein particle assembly (GO:0034379)5.81943569
17protein-lipid complex remodeling (GO:0034368)5.75143187
18macromolecular complex remodeling (GO:0034367)5.75143187
19plasma lipoprotein particle remodeling (GO:0034369)5.75143187
20reverse cholesterol transport (GO:0043691)5.71255668
21negative regulation of cholesterol transport (GO:0032375)5.65761796
22negative regulation of sterol transport (GO:0032372)5.65761796
23cholesterol efflux (GO:0033344)5.63156141
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.55926768
25complement activation, alternative pathway (GO:0006957)5.48168767
26intestinal cholesterol absorption (GO:0030299)5.26630319
27protein-lipid complex assembly (GO:0065005)5.20297985
28cellular glucuronidation (GO:0052695)5.07095092
29epoxygenase P450 pathway (GO:0019373)4.99188980
30drug catabolic process (GO:0042737)4.98987253
31uronic acid metabolic process (GO:0006063)4.96154362
32glucuronate metabolic process (GO:0019585)4.96154362
33blood coagulation, intrinsic pathway (GO:0007597)4.95504823
34fibrinolysis (GO:0042730)4.90333438
35plasma lipoprotein particle organization (GO:0071827)4.75594674
36low-density lipoprotein particle remodeling (GO:0034374)4.68993712
37exogenous drug catabolic process (GO:0042738)4.66642858
38regulation of plasminogen activation (GO:0010755)4.64877523
39negative regulation of lipase activity (GO:0060192)4.61157957
40aromatic amino acid family catabolic process (GO:0009074)4.53268183
41plasma lipoprotein particle clearance (GO:0034381)4.52352240
42triglyceride homeostasis (GO:0070328)4.52132768
43acylglycerol homeostasis (GO:0055090)4.52132768
44ethanol oxidation (GO:0006069)4.52073284
45negative regulation of protein activation cascade (GO:2000258)4.46038674
46positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.45684472
47protein-lipid complex subunit organization (GO:0071825)4.42339796
48bile acid biosynthetic process (GO:0006699)4.31055728
49urea metabolic process (GO:0019627)4.29247741
50regulation of triglyceride catabolic process (GO:0010896)4.27769151
51bile acid metabolic process (GO:0008206)4.22866220
52daunorubicin metabolic process (GO:0044597)4.20415514
53polyketide metabolic process (GO:0030638)4.20415514
54doxorubicin metabolic process (GO:0044598)4.20415514
55omega-hydroxylase P450 pathway (GO:0097267)4.15432681
56fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.10158655
57drug metabolic process (GO:0017144)4.04471662
58phospholipid homeostasis (GO:0055091)4.03354026
59negative regulation of blood coagulation (GO:0030195)4.01966343
60negative regulation of hemostasis (GO:1900047)4.01966343
61cholesterol homeostasis (GO:0042632)3.94035509
62regulation of bile acid biosynthetic process (GO:0070857)3.93245992
63sterol homeostasis (GO:0055092)3.87964011
64serine family amino acid catabolic process (GO:0009071)3.86942383
65negative regulation of coagulation (GO:0050819)3.84948605
66urea cycle (GO:0000050)3.84780355
67nitrogen cycle metabolic process (GO:0071941)3.82307524
68cholesterol transport (GO:0030301)3.79930060
69sterol transport (GO:0015918)3.79930060
70phenylpropanoid metabolic process (GO:0009698)3.79868747
71L-ascorbic acid metabolic process (GO:0019852)3.79037714
72aminoglycoside antibiotic metabolic process (GO:0030647)3.75923687
73positive regulation of triglyceride lipase activity (GO:0061365)3.74987839
74positive regulation of lipoprotein lipase activity (GO:0051006)3.74987839
75ethanol metabolic process (GO:0006067)3.74223207
76protein activation cascade (GO:0072376)3.72795405
77proline metabolic process (GO:0006560)3.70341069
78glycine metabolic process (GO:0006544)3.64132083
79lipoprotein metabolic process (GO:0042157)3.62839903
80intestinal absorption (GO:0050892)3.61757445
81negative regulation of wound healing (GO:0061045)3.60072594
82acute-phase response (GO:0006953)3.57200768
83negative regulation of complement activation (GO:0045916)3.54783822
84drug transmembrane transport (GO:0006855)3.53594122
85regulation of humoral immune response (GO:0002920)3.50344028
86regulation of apoptotic cell clearance (GO:2000425)3.48678770
87flavonoid metabolic process (GO:0009812)3.45283304
88bile acid and bile salt transport (GO:0015721)3.44750029
89complement activation, classical pathway (GO:0006958)3.37016931
90glutamate metabolic process (GO:0006536)3.35994274
91oxidative demethylation (GO:0070989)3.26358228
92tyrosine metabolic process (GO:0006570)3.26020027
93primary alcohol catabolic process (GO:0034310)3.25550195
94amino-acid betaine metabolic process (GO:0006577)3.24695748
95serine family amino acid metabolic process (GO:0009069)3.19450465
96drug transport (GO:0015893)3.18868420
97positive regulation of hemostasis (GO:1900048)3.16958773
98positive regulation of blood coagulation (GO:0030194)3.16958773
99heme transport (GO:0015886)3.15569740
100complement activation (GO:0006956)3.14851417

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.75305341
2EGR1_23403033_ChIP-Seq_LIVER_Mouse5.86824700
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.64880351
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.80618175
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.69232863
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.89163541
7HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.67387438
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.61582909
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.61425505
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.51327009
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.16851136
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.98170148
13FOXA2_19822575_ChIP-Seq_HepG2_Human2.81641264
14HNF4A_19822575_ChIP-Seq_HepG2_Human2.60715537
15CDX2_20551321_ChIP-Seq_CACO-2_Human2.23115417
16GATA4_25053715_ChIP-Seq_YYC3_Human2.06773334
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92484755
18TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.80617974
19* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.79883989
20SALL4_18804426_ChIP-ChIP_XEN_Mouse1.64992065
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62567573
22ESR1_15608294_ChIP-ChIP_MCF-7_Human1.48629497
23FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46070280
24GATA6_25053715_ChIP-Seq_YYC3_Human1.43623114
25ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32076715
26* SOX2_20726797_ChIP-Seq_SW620_Human1.31404764
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27407583
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26413031
29EOMES_21245162_ChIP-Seq_HESCs_Human1.23835302
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20556749
31SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18484157
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.16146767
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16096620
34TCF4_18268006_ChIP-ChIP_LS174T_Human1.15848056
35FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.14851357
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12799188
37AR_21909140_ChIP-Seq_LNCAP_Human1.12532265
38CDX2_22108803_ChIP-Seq_LS180_Human1.07766132
39SMAD3_21741376_ChIP-Seq_HESCs_Human1.07491325
40AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06739143
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.06494311
42BCAT_22108803_ChIP-Seq_LS180_Human1.05967179
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.04637467
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04423140
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02913227
46SMAD4_21741376_ChIP-Seq_HESCs_Human1.02834204
47FOXA1_25552417_ChIP-Seq_VCAP_Human1.02069949
48FOXO3_23340844_ChIP-Seq_DLD1_Human0.99687662
49HTT_18923047_ChIP-ChIP_STHdh_Human0.99384198
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98541482
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98500852
52KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95903892
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94325116
54PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93466625
55PIAS1_25552417_ChIP-Seq_VCAP_Human0.91613155
56KAP1_22055183_ChIP-Seq_ESCs_Mouse0.89320539
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88938344
58SOX2_19829295_ChIP-Seq_ESCs_Human0.88631992
59NANOG_19829295_ChIP-Seq_ESCs_Human0.88631992
60CBP_21632823_ChIP-Seq_H3396_Human0.88586906
61SOX17_20123909_ChIP-Seq_XEN_Mouse0.86818181
62AR_20517297_ChIP-Seq_VCAP_Human0.85793571
63SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.85553784
64TCF4_22108803_ChIP-Seq_LS180_Human0.82682010
65ZNF274_21170338_ChIP-Seq_K562_Hela0.82679534
66FLI1_27457419_Chip-Seq_LIVER_Mouse0.82207296
67PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81386189
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.80579030
69NFE2_27457419_Chip-Seq_LIVER_Mouse0.79437621
70CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.79257178
71KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.79008209
72CLOCK_20551151_ChIP-Seq_293T_Human0.78297892
73GATA3_24758297_ChIP-Seq_MCF-7_Human0.77805055
74PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.77720437
75TCF3_18692474_ChIP-Seq_MEFs_Mouse0.76326234
76CEBPB_22108803_ChIP-Seq_LS180_Human0.75843020
77RXRA_24833708_ChIP-Seq_LIVER_Mouse0.75039619
78FOXH1_21741376_ChIP-Seq_EPCs_Human0.74119116
79EZH2_27294783_Chip-Seq_NPCs_Mouse0.73541228
80SUZ12_27294783_Chip-Seq_NPCs_Mouse0.72905364
81TP53_18474530_ChIP-ChIP_U2OS_Human0.72302366
82SMAD4_21741376_ChIP-Seq_EPCs_Human0.72149271
83FOXA1_27270436_Chip-Seq_PROSTATE_Human0.69418148
84FOXA1_25329375_ChIP-Seq_VCAP_Human0.69418148
85PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.69274076
86FOXA1_21572438_ChIP-Seq_LNCaP_Human0.69177239
87CJUN_26792858_Chip-Seq_BT549_Human0.68853831
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.67933918
89ESR2_21235772_ChIP-Seq_MCF-7_Human0.66527705
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64738336
91NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64738336
92EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.63325150
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.63298382
94SMAD3_21741376_ChIP-Seq_EPCs_Human0.63200311
95TP53_16413492_ChIP-PET_HCT116_Human0.62929545
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.62541247
97POU3F2_20337985_ChIP-ChIP_501MEL_Human0.62298716
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.61596836
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.61397752
100P300_19829295_ChIP-Seq_ESCs_Human0.59945217

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.04316448
2MP0005360_urolithiasis6.49331366
3MP0005365_abnormal_bile_salt5.79257974
4MP0003195_calcinosis5.21609248
5MP0005085_abnormal_gallbladder_physiolo5.18361113
6MP0008875_abnormal_xenobiotic_pharmacok4.13014244
7MP0001666_abnormal_nutrient_absorption3.82658264
8MP0009840_abnormal_foam_cell3.48842042
9MP0010329_abnormal_lipoprotein_level3.45796857
10MP0003252_abnormal_bile_duct3.45455031
11MP0002138_abnormal_hepatobiliary_system3.42056564
12MP0003868_abnormal_feces_composition2.91392056
13MP0005332_abnormal_amino_acid2.35751236
14MP0002876_abnormal_thyroid_physiology1.98154081
15MP0009697_abnormal_copulation1.87785208
16MP0005408_hypopigmentation1.81584282
17MP0003191_abnormal_cellular_cholesterol1.80619383
18MP0004019_abnormal_vitamin_homeostasis1.80451606
19MP0002118_abnormal_lipid_homeostasis1.64861330
20MP0001764_abnormal_homeostasis1.58208700
21MP0002132_abnormal_respiratory_system1.57127010
22MP0000609_abnormal_liver_physiology1.55327185
23MP0003806_abnormal_nucleotide_metabolis1.54827691
24MP0003890_abnormal_embryonic-extraembry1.50199178
25MP0005084_abnormal_gallbladder_morpholo1.49637020
26MP0004272_abnormal_basement_membrane1.41434325
27MP0005670_abnormal_white_adipose1.36727253
28MP0010368_abnormal_lymphatic_system1.36344231
29MP0003122_maternal_imprinting1.29345876
30MP0000566_synostosis1.20402339
31MP0002089_abnormal_postnatal_growth/wei1.15535203
32MP0009643_abnormal_urine_homeostasis1.11727419
33MP0005636_abnormal_mineral_homeostasis1.05034277
34MP0003283_abnormal_digestive_organ1.04220983
35MP0006054_spinal_hemorrhage1.04132758
36MP0000598_abnormal_liver_morphology1.00842012
37MP0005220_abnormal_exocrine_pancreas1.00423984
38MP0005319_abnormal_enzyme/_coenzyme0.97455024
39MP0004264_abnormal_extraembryonic_tissu0.93158407
40MP0005083_abnormal_biliary_tract0.91694662
41MP0001915_intracranial_hemorrhage0.90972202
42MP0003186_abnormal_redox_activity0.89224542
43MP0001661_extended_life_span0.86907009
44MP0008872_abnormal_physiological_respon0.84901381
45MP0003123_paternal_imprinting0.82707187
46MP0005058_abnormal_lysosome_morphology0.82364201
47MP0004133_heterotaxia0.81916127
48MP0003718_maternal_effect0.81014682
49MP0001756_abnormal_urination0.80013736
50MP0002254_reproductive_system_inflammat0.77878116
51MP0009642_abnormal_blood_homeostasis0.77511836
52MP0000604_amyloidosis0.77389179
53MP0000639_abnormal_adrenal_gland0.76558177
54MP0005257_abnormal_intraocular_pressure0.76152181
55MP0005584_abnormal_enzyme/coenzyme_acti0.74138970
56MP0005395_other_phenotype0.70092477
57MP0005451_abnormal_body_composition0.68783559
58MP0003567_abnormal_fetal_cardiomyocyte0.68469785
59MP0005187_abnormal_penis_morphology0.67491261
60MP0004043_abnormal_pH_regulation0.67033532
61MP0003943_abnormal_hepatobiliary_system0.66705245
62MP0010030_abnormal_orbit_morphology0.65462523
63MP0003119_abnormal_digestive_system0.64785387
64MP0010386_abnormal_urinary_bladder0.62621395
65MP0005376_homeostasis/metabolism_phenot0.58935265
66MP0002938_white_spotting0.58365779
67MP0005551_abnormal_eye_electrophysiolog0.58238187
68MP0002233_abnormal_nose_morphology0.56222367
69MP0002078_abnormal_glucose_homeostasis0.56033419
70MP0005379_endocrine/exocrine_gland_phen0.55199149
71MP0003136_yellow_coat_color0.54196100
72MP0003315_abnormal_perineum_morphology0.53193962
73MP0002282_abnormal_trachea_morphology0.52268838
74MP0008004_abnormal_stomach_pH0.51192558
75MP0000516_abnormal_urinary_system0.50462297
76MP0005367_renal/urinary_system_phenotyp0.50462297
77MP0002090_abnormal_vision0.49716619
78MP0005448_abnormal_energy_balance0.49249953
79MP0003953_abnormal_hormone_level0.48620480
80MP0001324_abnormal_eye_pigmentation0.48528576
81MP0003638_abnormal_response/metabolism_0.47419301
82MP0002909_abnormal_adrenal_gland0.47165254
83MP0003011_delayed_dark_adaptation0.44070310
84MP0000462_abnormal_digestive_system0.42847312
85MP0005023_abnormal_wound_healing0.40599017
86MP0005410_abnormal_fertilization0.40382132
87MP0001944_abnormal_pancreas_morphology0.40293516
88MP0000538_abnormal_urinary_bladder0.39894065
89MP0002168_other_aberrant_phenotype0.39527692
90MP0001270_distended_abdomen0.38728573
91MP0002928_abnormal_bile_duct0.38600810
92MP0008469_abnormal_protein_level0.38138009
93MP0005464_abnormal_platelet_physiology0.37891893
94MP0009384_cardiac_valve_regurgitation0.36802291
95MP0003950_abnormal_plasma_membrane0.36266270
96MP0005164_abnormal_response_to0.35990622
97MP0002136_abnormal_kidney_physiology0.35262078
98MP0003172_abnormal_lysosome_physiology0.35102764
99MP0005330_cardiomyopathy0.34313454
100MP0003879_abnormal_hair_cell0.33690370

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)8.64679987
2Hypobetalipoproteinemia (HP:0003563)8.17704207
3Prolonged partial thromboplastin time (HP:0003645)7.54740882
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.72317111
5Abnormality of aromatic amino acid family metabolism (HP:0004338)6.55464778
6Complement deficiency (HP:0004431)6.34444235
7Joint hemorrhage (HP:0005261)5.55681390
8Hypolipoproteinemia (HP:0010981)5.47418874
9Abnormality of the common coagulation pathway (HP:0010990)5.04299302
10Abnormality of complement system (HP:0005339)4.86257773
11Spontaneous abortion (HP:0005268)4.85601667
12Intrahepatic cholestasis (HP:0001406)4.75427351
13Xanthomatosis (HP:0000991)4.73329342
14Systemic lupus erythematosus (HP:0002725)4.44024040
15Glomerulonephritis (HP:0000099)4.34335909
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.26210083
17Conjugated hyperbilirubinemia (HP:0002908)4.23169698
18Hypoalphalipoproteinemia (HP:0003233)3.85767403
19Hyperlipoproteinemia (HP:0010980)3.78807599
20Hyperglycinemia (HP:0002154)3.78029831
21Fat malabsorption (HP:0002630)3.74543316
22Abnormality of glutamine family amino acid metabolism (HP:0010902)3.56911269
23Abnormality of pyrimidine metabolism (HP:0004353)3.42259537
24Hypercholesterolemia (HP:0003124)3.33812625
25Vascular calcification (HP:0004934)3.12121502
26Abnormality of serine family amino acid metabolism (HP:0010894)3.08886003
27Abnormality of glycine metabolism (HP:0010895)3.08886003
28Abnormality of methionine metabolism (HP:0010901)2.95636832
29Hyperglycinuria (HP:0003108)2.94023285
30Gingival bleeding (HP:0000225)2.84454370
31Delayed CNS myelination (HP:0002188)2.82268857
32Steatorrhea (HP:0002570)2.79937763
33Hemorrhage of the eye (HP:0011885)2.77286975
34Hyperammonemia (HP:0001987)2.75795518
35Glycosuria (HP:0003076)2.74599005
36Abnormality of urine glucose concentration (HP:0011016)2.74599005
37Epidermoid cyst (HP:0200040)2.73155361
38Generalized aminoaciduria (HP:0002909)2.72870219
39Abnormality of the intrinsic pathway (HP:0010989)2.70487174
40Nephritis (HP:0000123)2.69279964
41Cardiovascular calcification (HP:0011915)2.67599989
42Mitral stenosis (HP:0001718)2.67094359
43Abnormality of serum amino acid levels (HP:0003112)2.65533266
44Menorrhagia (HP:0000132)2.64998066
45Acanthocytosis (HP:0001927)2.63909975
46Hydroxyprolinuria (HP:0003080)2.62272867
47Abnormality of proline metabolism (HP:0010907)2.62272867
48Abnormality of aspartate family amino acid metabolism (HP:0010899)2.58102716
49Reduced antithrombin III activity (HP:0001976)2.51489306
50Enlarged kidneys (HP:0000105)2.49940284
51Increased serum pyruvate (HP:0003542)2.46234090
52Hepatocellular carcinoma (HP:0001402)2.44111730
53Abnormal tarsal ossification (HP:0008369)2.43923265
54Arthropathy (HP:0003040)2.39926364
55Gout (HP:0001997)2.36334311
56Hypophosphatemic rickets (HP:0004912)2.35747569
57Rickets (HP:0002748)2.35497570
58Osteomalacia (HP:0002749)2.33037785
59Hypoglycemic coma (HP:0001325)2.27558312
60Facial shape deformation (HP:0011334)2.20413556
61Potter facies (HP:0002009)2.20413556
62Abnormality of carpal bone ossification (HP:0006257)2.19695352
63Abnormality of nucleobase metabolism (HP:0010932)2.18694311
64Retinal atrophy (HP:0001105)2.18643817
65Abnormality of glycolysis (HP:0004366)2.18181766
66Amyloidosis (HP:0011034)2.18005283
67Proximal tubulopathy (HP:0000114)2.13918171
68Abnormality of vitamin metabolism (HP:0100508)2.12444350
69Thrombophlebitis (HP:0004418)2.12054494
70Hyperphosphaturia (HP:0003109)2.08194873
71Late onset (HP:0003584)2.03925886
72Abnormality of sulfur amino acid metabolism (HP:0004339)2.03513190
73Pancreatic islet-cell hyperplasia (HP:0004510)2.03014768
74Abnormal delivery (HP:0001787)1.99595965
75Bifid scrotum (HP:0000048)1.94965421
76Metabolic acidosis (HP:0001942)1.92114627
77Myocardial infarction (HP:0001658)1.86256990
78Hepatoblastoma (HP:0002884)1.86137029
79Hyperbilirubinemia (HP:0002904)1.82813485
80Pigmentary retinal degeneration (HP:0001146)1.81736387
81Vaginal fistula (HP:0004320)1.80009441
82Recurrent gram-negative bacterial infections (HP:0005420)1.78024989
83Joint swelling (HP:0001386)1.76769654
84Purpura (HP:0000979)1.70823892
85Broad alveolar ridges (HP:0000187)1.69626503
86Nausea (HP:0002018)1.69260219
87Lethargy (HP:0001254)1.68261913
88Abnormal urine phosphate concentration (HP:0012599)1.66466426
89Abnormality of alanine metabolism (HP:0010916)1.65481466
90Hyperalaninemia (HP:0003348)1.65481466
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.65481466
92Poikilocytosis (HP:0004447)1.63860574
93Cerebral palsy (HP:0100021)1.63454303
94Hypothermia (HP:0002045)1.62168807
95Abnormality of purine metabolism (HP:0004352)1.62060249
96Neoplasm of the liver (HP:0002896)1.60880637
97Abnormality of the vitreous humor (HP:0004327)1.58495507
98Prenatal maternal abnormality (HP:0002686)1.57666488
99Skin nodule (HP:0200036)1.55754959
100Ketosis (HP:0001946)1.53443207

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK25.10850192
2PDK24.93717448
3ERBB43.79122359
4FGFR43.70645659
5ACVR1B3.30468255
6PBK2.89153390
7EPHA22.68989409
8MST1R2.12860475
9ERN12.10958353
10BCKDK2.07034751
11PIK3CA2.06583146
12WNK41.99130761
13MAP3K121.93796877
14FGFR31.82780828
15BMPR1B1.79426674
16FGFR21.77885745
17EPHA41.70646003
18STK391.66141727
19WNK31.64472605
20FGFR11.56383930
21GRK11.42934509
22EIF2AK31.39393395
23AKT31.37104961
24MET1.35087801
25NEK11.32676756
26BRSK21.30787696
27FRK1.27494630
28PRKG21.20759295
29MAPK111.16791508
30STK161.14527125
31PRKAA21.09724710
32ERBB21.08409337
33PIK3CG1.06704738
34VRK21.02180186
35RIPK11.01474300
36MST41.00492723
37TESK21.00128811
38FLT30.96636786
39BCR0.96033603
40TNIK0.94012701
41NEK20.91949231
42MAP4K20.89665142
43MYLK0.88063270
44LATS10.87343656
45STK38L0.87323526
46OXSR10.87149260
47CASK0.86639366
48INSRR0.86167956
49NME10.84404341
50MUSK0.84029401
51EIF2AK10.83971782
52FER0.83850629
53PRKCE0.79676170
54LIMK10.79168426
55TESK10.76310182
56PKN20.75790959
57ICK0.74591492
58MAPKAPK30.74192087
59PRKCG0.73613275
60PRKACG0.70219234
61TGFBR20.68629217
62PHKG10.66955806
63PHKG20.66955806
64DAPK10.61723270
65WEE10.60432608
66PDGFRA0.58902480
67BRSK10.55912514
68NUAK10.55465908
69PRKAA10.54060315
70TRIM280.51724804
71IGF1R0.49695842
72ABL20.48893460
73PDPK10.48402368
74CSNK1G10.47442199
75TAF10.47097597
76NTRK30.44197488
77MELK0.43355032
78CSNK2A10.43130559
79CSNK1A10.43124019
80CDK70.42746349
81PRKG10.42070593
82CSNK1E0.41847568
83CSNK2A20.41773638
84PINK10.41402373
85MAP3K20.40939932
86PLK30.40377741
87CDK90.39924288
88ZAK0.39656335
89CSNK1A1L0.37620657
90PRKACB0.37401678
91TIE10.36729632
92PAK40.35560720
93KDR0.35109811
94PRKCQ0.34993555
95CDK80.34227260
96ROCK10.33966869
97CSNK1D0.33745294
98PRKCA0.32477829
99PRKACA0.28890906
100PTK20.26295309

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046103.65484040
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40215265
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.39678435
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.86492678
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.84232649
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.83020407
7Retinol metabolism_Homo sapiens_hsa008302.59248932
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.58667066
9Caffeine metabolism_Homo sapiens_hsa002322.53317586
10Chemical carcinogenesis_Homo sapiens_hsa052042.44688608
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.44128791
12Steroid hormone biosynthesis_Homo sapiens_hsa001402.32148008
13Fatty acid degradation_Homo sapiens_hsa000712.28604778
14Arginine biosynthesis_Homo sapiens_hsa002202.27742452
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.12227811
16Fat digestion and absorption_Homo sapiens_hsa049752.07716337
17Butanoate metabolism_Homo sapiens_hsa006502.05326571
18Drug metabolism - other enzymes_Homo sapiens_hsa009832.02497880
19Phenylalanine metabolism_Homo sapiens_hsa003601.95227241
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.88098462
21Histidine metabolism_Homo sapiens_hsa003401.84622662
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.79979550
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.77938098
24Starch and sucrose metabolism_Homo sapiens_hsa005001.71319135
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.69494820
26Tyrosine metabolism_Homo sapiens_hsa003501.68141179
27Tryptophan metabolism_Homo sapiens_hsa003801.66958642
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.66879804
29PPAR signaling pathway_Homo sapiens_hsa033201.64395539
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60304698
31Propanoate metabolism_Homo sapiens_hsa006401.57803539
32Bile secretion_Homo sapiens_hsa049761.53947872
33Vitamin digestion and absorption_Homo sapiens_hsa049771.51303671
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50032846
35Peroxisome_Homo sapiens_hsa041461.48727629
36Pyruvate metabolism_Homo sapiens_hsa006201.46701136
37Arginine and proline metabolism_Homo sapiens_hsa003301.39800041
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31718916
39beta-Alanine metabolism_Homo sapiens_hsa004101.25650046
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25605995
41Fatty acid metabolism_Homo sapiens_hsa012121.24717354
42Sulfur metabolism_Homo sapiens_hsa009201.23927141
43Steroid biosynthesis_Homo sapiens_hsa001001.23368580
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.18134435
45Linoleic acid metabolism_Homo sapiens_hsa005911.18105252
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.17799235
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15355826
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14904465
49Biosynthesis of amino acids_Homo sapiens_hsa012301.10554037
50Vitamin B6 metabolism_Homo sapiens_hsa007501.09661838
51Carbon metabolism_Homo sapiens_hsa012001.08029243
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07817358
53Glutathione metabolism_Homo sapiens_hsa004800.93776384
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84979365
55Fatty acid elongation_Homo sapiens_hsa000620.83235365
56Arachidonic acid metabolism_Homo sapiens_hsa005900.81890702
57Galactose metabolism_Homo sapiens_hsa000520.80706096
58ABC transporters_Homo sapiens_hsa020100.77959987
59Sulfur relay system_Homo sapiens_hsa041220.76018897
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72308529
61Staphylococcus aureus infection_Homo sapiens_hsa051500.71428584
62Nitrogen metabolism_Homo sapiens_hsa009100.70156710
63Glycerolipid metabolism_Homo sapiens_hsa005610.69516617
64Fructose and mannose metabolism_Homo sapiens_hsa000510.69145856
65Metabolic pathways_Homo sapiens_hsa011000.64909873
66Renin-angiotensin system_Homo sapiens_hsa046140.63267064
67Other glycan degradation_Homo sapiens_hsa005110.62766938
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59715894
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.59658501
70One carbon pool by folate_Homo sapiens_hsa006700.55872783
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52038122
72Selenocompound metabolism_Homo sapiens_hsa004500.51952943
73Lysine degradation_Homo sapiens_hsa003100.49381296
74Mineral absorption_Homo sapiens_hsa049780.48615937
75N-Glycan biosynthesis_Homo sapiens_hsa005100.48609047
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35512957
77Prion diseases_Homo sapiens_hsa050200.34676492
78Folate biosynthesis_Homo sapiens_hsa007900.33776963
79Pentose phosphate pathway_Homo sapiens_hsa000300.33379298
80Sphingolipid metabolism_Homo sapiens_hsa006000.32988288
81Proteasome_Homo sapiens_hsa030500.30119994
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26673888
83Fatty acid biosynthesis_Homo sapiens_hsa000610.25095156
84Protein digestion and absorption_Homo sapiens_hsa049740.22247271
85Glucagon signaling pathway_Homo sapiens_hsa049220.20003581
86Thyroid hormone synthesis_Homo sapiens_hsa049180.17194062
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15533026
88Protein export_Homo sapiens_hsa030600.14088669
89Ether lipid metabolism_Homo sapiens_hsa005650.12636383
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.07566456
91TGF-beta signaling pathway_Homo sapiens_hsa043500.06567821
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.02962045
93Insulin resistance_Homo sapiens_hsa049310.02454061
94Pertussis_Homo sapiens_hsa051330.02154421
95Pancreatic secretion_Homo sapiens_hsa049720.00981894
96Lysosome_Homo sapiens_hsa04142-0.0757800
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0700131
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0684889
99Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0551730
100Vibrio cholerae infection_Homo sapiens_hsa05110-0.0330614

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